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A non-toxic recombinant bivalent chimeric protein rETXCSA as a potential vaccine candidate against enterotoxemia and braxy

Authors: Jige Du, Bo Liu, Tuanjie Wang, Zhen Zhu, Chunsheng Yin, Yufeng Luo, Ying Liu, Xiaoyun Chen

Journal: Vaccine

PubMed ID: 36635138

Doi: 10.1016/j.vaccine.2022.11.021

Products & Services: Molecular Biology Reagents

Omicron variants breakthrough infection elicited higher specific memory immunity than third dose booster in healthy vaccinees

Authors: Pei Yu, Zijian Liu, Zhuoqi Zhu, Jiaqing Yang, Min Deng, Mingxiao Chen, Changchun Lai, Weiya Kong, Shilong Xiong, Li Wan, Weikang Mai, Lu Chen, Yu Lei, Shahzad Akbar Khan, Jianfeng Ruan, An Kang, Xuguang Guo, Qiang Zhou, Wenrui Li, Zheng Chen, Yuemei Liang, Pingchao Li, Lei Zhang, Tianxing Ji

Journal: Virol Sin

PubMed ID: 36603767

Doi: 10.1016/j.virs.2022.12.008

Products & Services: Molecular Biology Reagents

Transcriptomic exploration of the Coleopteran wings reveals insight into the evolution of novel structures associated with the beetle elytron

Authors: David M Linz, Yuichiro Hara, Kevin D Deem, Shigehiro Kuraku, Shigeo Hayashi, Yoshinori Tomoyasu

Journal: J Exp Zool B Mol Dev Evol

PubMed ID: 36617687

Doi: 10.1002/jez.b.23188

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Nanocell COVID-19 vaccine triggers a novel immune response pathway producing high-affinity antibodies which neutralize all variants of concern

Authors: Steven Y Gao, Nancy B Amaro-Mugridge, Jocelyn Madrid-Weiss, Nikolina Petkovic, Natasha Vanegas, Kumar Visvanathan, Bryan R G Williams, Jennifer A MacDiarmid, Himanshu Brahmbhatt

Journal: Front Immunol

PubMed ID: 36818474

Doi: 10.3389/fimmu.2022.1038562

Products & Services: Molecular Biology Reagents

Detection and Molecular Characterization of the SARS-CoV-2 Delta Variant and the Specific Immune Response in Companion Animals in Switzerland

Authors: Evelyn Kuhlmeier, Tatjana Chan, Cecilia Valenzuela Agüí, Barbara Willi, Aline Wolfensberger, Christian Beisel, Ivan Topolsky, Niko Beerenwinkel, Tanja Stadler, Sarah Jones, Grace Tyson, Margaret J Hosie, Katja Reitt, Julia Hüttl, Marina L Meli, Regina Hofmann-Lehmann

Journal: Viruses

PubMed ID: 36680285

Doi: 10.3390/v15010245

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Depletion of microglial BDNF increases susceptibility to the behavioral and synaptic effects of chronic unpredictable stress

Authors: Samuel C Woodburn, Helina S Asrat, James K Flurer, Hana C Schwierling, Justin L Bollinger, Lauren L Vollmer, Eric S Wohleb

Journal: Brain Behav Immun

PubMed ID: 36681359

Doi: 10.1016/j.bbi.2023.01.014

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PLK1 and AURKB phosphorylate survivin differentially to affect proliferation in racially distinct triple-negative breast cancer

Authors: Chakravarthy Garlapati, Shriya Joshi, Shristi Bhattarai, Jayashree Krishnamurthy, Ravi Chakra Turaga, Thi Nguyen, Xiaoxian Li, Ritu Aneja

Journal: Cell Death Dis

PubMed ID: 36627281

Doi: 10.1038/s41419-022-05539-5

Products & Services: Molecular Biology Reagents

Chronic intermittent hypoxia-induced BNIP3 expression mitigates contractile dysfunction and myocardial injury in animal and cell model via modulating autophagy

Authors: Ruifang Chi, Chanjuan Chai, Gaizhen Liu, Huili Cao, Bin Yang

Journal: Hum Cell

PubMed ID: 36627546

Doi: 10.1007/s13577-022-00851-w

Products & Services: Molecular Biology Reagents

Pold4 is dispensable for mouse development, DNA replication and DNA repair

Authors: Xueping Gu , Qinjin Dai , Peng Du , Ning Li , Jiahui Li , Simiao Zeng , Shuyi Peng , Shengjun Tang , Lei Wang , Zhongcheng Zhou

Journal: Gene

PubMed ID: 36356905

Doi: 10.1016/j.gene.2022.147029

Products & Services: Protein Electrophoresis and Western

A method for mapping the linear epitopes targeted by the natural antibody response to Zika virus infection using a VLP platform technology

Authors: Alexandra Fowler, Chunyan Ye, Elizabeth C Clarke, Juan M Pascale, David S Peabody, Steven B Bradfute, Kathryn M Frietze, Bryce Chackerian

Journal: Virology

PubMed ID: 36623351

Doi: 10.1016/j.virol.2023.01.001

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CRISPR mediated transactivation in the human disease vector Aedes aegypti

Authors: Michelle Bui, Elena Dalla Benetta, Yuemei Dong, Yunchong Zhao, Ting Yang, Ming Li, Igor A Antoshechkin, Anna Buchman, Vanessa Bottino-Rojas, Anthony A James, Michael W Perry, George Dimopoulos, Omar S Akbari

Journal: PLoS Pathog

PubMed ID: 36656895

Doi: 10.1371/journal.ppat.1010842

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Atlantic cod () MHC I localizes to endolysosomal compartments independently of cytosolic sorting signals

Authors: Synne Arstad Bjørnestad, Monica Hongrø Solbakken, Kjetill S Jakobsen, Sissel Jentoft, Oddmund Bakke, Cinzia Progida

Journal: Front Cell Dev Biol

PubMed ID: 36760361

Doi: 10.3389/fcell.2023.1050323

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Circ-N4BP2L2 enhances mitochondrial function in non-small cell lung cancer cells through regulating the miR-135a-5p/ARL5B axis

Authors: Hongyang Shi, Yuqiang Ji, Yonghong Zhang, Yu Wang, Wei Li

Journal: Environ Toxicol

PubMed ID: 36637163

Doi: 10.1002/tox.23736

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SARS-CoV-2-free residual proteins mediated phenotypic and metabolic changes in peripheral blood monocytic-derived macrophages in support of viral pathogenesis

Authors: Mohammad G Mohammad, Naglaa S Ashmawy, Ahmed M Al-Rawi, Ameera Abu-Qiyas, Alshaimaa M Hamoda, Rania Hamdy, Salam Dakalbab, Shahad Arikat, Dana Salahat, Mohamed Madkour, Sameh S M Soliman

Journal: PLoS ONE

PubMed ID: 36656874

Doi: 10.1371/journal.pone.0280592

Products & Services: Molecular Biology Reagents

The c-di-AMP-binding protein CbpB modulates the level of ppGpp alarmone in Streptococcus agalactiae

Authors: Giovanni Covaleda-Cortés, Ariel Mechaly, Terry Brissac, Heike Baehre, Laura Devaux, Patrick England, Bertrand Raynal, Sylviane Hoos, Myriam Gominet, Arnaud Firon, Patrick Trieu-Cuot, Pierre Alexandre Kaminski

Journal: FEBS J

PubMed ID: 36629470

Doi: 10.1111/febs.16724

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Characterizing asparagine synthetase deficiency variants in lymphoblastoid cell lines

Authors: Stephen J Staklinski, Mario C Chang, Rebecca C Ahrens-Nicklas, Shagun Kaur, Arianna K Stefanatos, Elizabeth E Dudenhausen, Matthew E Merritt, Michael S Kilberg

Journal: JIMD Rep

PubMed ID: 36873094

Doi: 10.1002/jmd2.12356

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Linoleic acid ameliorates intestinal mucosal barrier injury in early weaned pigeon squabs (Columba livia)

Authors: Qianqian Xu, Jin Zhao, Huafeng Jian, Jiangcheng Ye, Mingxiu Gong, Xiaoting Zou, Xinyang Dong

Journal: J Anim Sci

PubMed ID: 37186172

Doi: 10.1093/jas/skad125

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Magnaporthe oryzae pathotype Triticum (MoT) can act as a heterologous expression system for fungal effectors with high transcript abundance in wheat

Authors: Cassandra Jensen, Diane G O Saunders

Journal: Sci Rep

PubMed ID: 36596834

Doi: 10.1038/s41598-022-27030-z

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Genetic code expansion reveals aminoacylated lysine ubiquitination mediated by UBE2W

Authors: Jia Zang, Yulin Chen, Chao Liu, Linzhen Hu, Hongxia Zhao, Wenlong Ding, Ying Yuan, Shixian Lin

Journal: Nat Struct Mol Biol

PubMed ID: 36593310

Doi: 10.1038/s41594-022-00866-9

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RACK1 release from the Ribosome Couples Translational Regulation with Starving Signaling and Possibly Depends on Phosphorylation of Key Serine and Threonine Residues

Authors: Maria Kiratzis, Giancarlo Lai, Piera Calamita, Marilena Mancino, Marcello Iriti, Nicola Manfrini, Simone Gallo

Journal: Cell Mol Biol (Noisy-le-grand)

PubMed ID: 37213164

Doi: 10.14715/cmb/2022.69.1.2

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Maltose-Enhanced Exopolysaccharide Synthesis of through CRP-like Protein

Authors: Fanqiang Meng, Yunbin Lyu, Xiaoyu Chen, Fengxia Lu, Haizhen Zhao, Yingjian Lu, Mingwen Zhao, Zhaoxin Lu

Journal: J Agric Food Chem

PubMed ID: 36602107

Doi: 10.1021/acs.jafc.2c07880

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Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q133 microdeletion syndrome

Authors: Brianna K Unda, Leon Chalil, Sehyoun Yoon, Savannah Kilpatrick, Courtney Irwin, Sansi Xing, Nadeem Murtaza, Anran Cheng, Chad Brown, Alexandria Afonso, Elizabeth McCready, Gabriel M Ronen, Jennifer Howe, Aurélie Caye-Eude, Alain Verloes, Brad W Doble, Laurence Faivre, Antonio Vitobello, Stephen W Scherer, Yu Lu, Peter Penzes, Karun K Singh

Journal: Mol Psychiatry

PubMed ID: 36604605

Doi: 10.1038/s41380-022-01937-5

Products & Services: DNA Sequencing

Mesenchymal stem cell-derived extracellular vesicles transfer miR-598 to inhibit the growth and metastasis of non-small-cell lung cancer by targeting THBS2

Authors: Xuebo Li, Fan Wu

Journal: Cell Death Discov

PubMed ID: 36609437

Doi: 10.1038/s41420-022-01283-z

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Synaptic vesicle proteins and ATG9A self-organize in distinct vesicle phases within synapsin condensates

Authors: Daehun Park, Yumei Wu, Xinbo Wang, Swetha Gowrishankar, Aaron Baublis, Pietro De Camilli

Journal: Nat Commun

PubMed ID: 36709207

Doi: 10.1038/s41467-023-36081-3

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Structural Characterization of Porcine Adeno-Associated Virus Capsid Protein with Nuclear Trafficking Protein Importin Alpha Reveals a Bipartite Nuclear Localization Signal

Authors: Mikayla Hoad, Emily M Cross, Camilla M Donnelly, Subir Sarker, Justin A Roby, Jade K Forwood

Journal: Viruses

PubMed ID: 36851528

Doi: 10.3390/v15020315

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Label-free impedimetric immunosensor for point-of-care detection of COVID-19 antibodies

Authors: Lian C T Shoute, Gaser N Abdelrasoul, Yuhao Ma, Pedro A Duarte, Cole Edwards, Ran Zhuo, Jie Zeng, Yiwei Feng, Carmen L Charlton, Jamil N Kanji, Shawn Babiuk, Jie Chen

Journal: Microsyst Nanoeng

PubMed ID: 36597510

Doi: 10.1038/s41378-022-00460-5

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Long-term blue light exposure impairs mitochondrial dynamics in the retina in light-induced retinal degeneration in vivo and in vitro

Authors: Liyin Wang, Xin Yu, Dongyan Zhang, Yingying Wen, Liyue Zhang, Yutong Xia, Jinbo Chen, Chen Xie, Hong Zhu, Jianping Tong, Ye Shen

Journal: J Photochem Photobiol B

PubMed ID: 36724628

Doi: 10.1016/j.jphotobiol.2023.112654

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Loss-of-function KCa2.2 mutations abolish channel activity

Authors: Young-Woo Nam , Mohammad Asikur Rahman , Grace Yang , Razan Orfali , Meng Cui , Miao Zhang

Journal: Am J Physiol Cell Physiol

PubMed ID: 36717104

Doi: 10.1152/ajpcell.00584.2022

Products & Services: PCR Cloning and Subcloning

Expression and kinetic characterization of PYCR3 Kaylen

Authors: Kaylen R Meeks , John J Tanner

Journal: Arch Biochem Biophys

PubMed ID: 36414121

Doi: 10.1016/j.abb.2022.109468

Products & Services: Codon Optimization

Indolethylamine N-methyltransferase (INMT) is not essential for endogenous tryptamine-dependent methylation activity in rats

Authors: NicolasG.Glynos, Lily Carter, Soo Jung Lee, Youngsoo Kim , RobertT. Kennedy, GeorgeA. Mashour, Michael M. Wang & Jimo Borjigin

Journal: Scientific REPORTS

PubMed ID: 36609666

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Radiotherapy-Triggered Proteolysis Targeting Chimera Prodrug Activation in Tumors

Authors: Chunrong Yang , Yuchen Yang , Yujie Li , Qiankun Ni , Jinghong Li

Journal: J Am Chem Soc.

PubMed ID: 36542856

Doi: 10.1021/jacs.2c10177

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Activity, Template Preference, and Compatibility of Components of RNA Replicase of Eastern Equine Encephalitis Virus

Authors: Laura Sandra Lello, Agneta Miilimäe, Liubov Cherkashchenko, Ailar Omler, Rachel Skilton, Rachel Ireland, David Ulaeto, Andres Merits

Journal: J Virol

PubMed ID: 36533950

Doi: 10.1128/jvi.01368-22

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RsCLE22a regulates taproot growth through an auxin signaling-related pathway in radish (Raphanus sativus L)

Authors: Junhui Dong, Yan Wang, Liang Xu, Bingshuang Li, Kai Wang, Jiali Ying, Qing He, Liwang Liu

Journal: J Exp Bot

PubMed ID: 36239471

Doi: 10.1093/jxb/erac406

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Precision targeting of autoantigen-specific B cells in muscle-specific tyrosine kinase myasthenia gravis with chimeric autoantibody receptor T cells

Authors: Sangwook Oh, Xuming Mao, Silvio Manfredo-Vieira, Jinmin Lee, Darshil Patel, Eun Jung Choi, Andrea Alvarado, Ebony Cottman-Thomas, Damian Maseda, Patricia Y Tsao, Christoph T Ellebrecht, Sami L Khella, David P Richman, Kevin C O'Connor, Uri Herzberg, Gwendolyn K Binder, Michael C Milone, Samik Basu, Aimee S Payne

Journal: Nat Biotechnol

PubMed ID: 36658341

Doi: 10.1038/s41587-022-01637-z

Products & Services: Protein and Antibody Isolation

Ensemble-based, high-throughput virtual screening of potential inhibitor targeting putative farnesol dehydrogenase of Metisa plana (Lepidoptera: Psychidae)

Authors: Anis Nadyra Zifruddin, Mohamad Ariff Mohamad Yusoff, Nur Syatila Abd Ghani, Nor Azlan Nor Muhammad, Kok Wai Lam, Maizom Hassan

Journal: Comput Biol Chem

PubMed ID: 36645937

Doi: 10.1016/j.compbiolchem.2023.107811

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A single, improbable B cell receptor mutation confers potent neutralization against cytomegalovirus

Authors: Jennifer A Jenks, Sharmi Amin, Madeline R Sponholtz, Amit Kumar, Daniel Wrapp, Sravani Venkatayogi, Joshua J Tu, Krithika Karthigeyan, Sarah M Valencia, Megan Connors, Melissa J Harnois, Bhavna Hora, Eric Rochat, Jason S McLellan, Kevin Wiehe, Sallie R Permar

Journal: PLoS Pathog

PubMed ID: 36662906

Doi: 10.1371/journal.ppat.1011107

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The neoepitope of the complement C5b-9 Membrane Attack Complex is formed by proximity of adjacent ancillary regions of C9

Authors: Charles Bayly-Jones, Bill H T Ho, Corinna Lau, Eleanor W W Leung, Laura D'Andrea, Christopher J Lupton, Susan M Ekkel, Hariprasad Venugopal, James C Whisstock, Tom E Mollnes, Bradley A Spicer, Michelle A Dunstone

Journal: Commun Biol

PubMed ID: 36639734

Doi: 10.1038/s42003-023-04431-y

Products & Services: DNA Sequencing

An OsPRMT5-OsAGO2/miR1875-OsHXK1 module regulates rice immunity to blast disease

Authors: Cong Sheng, Xuan Li, Shengge Xia, Yimai Zhang, Ze Yu, Cheng Tang, Le Xu, Zhaoyun Wang, Xin Zhang, Tong Zhou, Pingping Nie, Ayesha Baig, Dongdong Niu, Hongwei Zhao

Journal: J Integr Plant Biol

PubMed ID: 36511124

Doi: 10.1111/jipb.13430

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Performance evaluation of the Ortho VITROS SARS-CoV-2 Spike-Specific Quantitative IgG test by comparison with the surrogate virus neutralizing antibody test and clinical assessment

Authors: Maika Takahashi, Kaori Saito, Tomohiko Ai, Shuko Nojiri, Abdullah Khasawneh, Faith Jessica Paran, Yuki Horiuchi, Satomi Takei, Takamasa Yamamoto, Mitsuru Wakita, Makoto Hiki, Takashi Miida, Toshio Naito, Kazuhisa Takahashi, Yoko Tabe

Journal: PLoS ONE

PubMed ID: 36693058

Doi: 10.1371/journal.pone.0279779

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A novel secreted protein, NISP1, is phosphorylated by soybean Nodulation Receptor Kinase to promote nodule symbiosis

Authors: Baolan Fu, Zhipeng Xu, Yutao Lei, Ru Dong, Yanan Wang, Xiaoli Guo, Hui Zhu, Yangrong Cao, Zhe Yan

Journal: J Integr Plant Biol

PubMed ID: 36534458

Doi: 10.1111/jipb.13436

Products & Services: Recombinant Proteins

Structural domains of SARS-CoV-2 nucleocapsid protein coordinate to compact long nucleic acid substrates

Authors: Michael Morse, Jana Sefcikova, Ioulia Rouzina, Penny J Beuning, Mark C Williams

Journal: Nucleic Acids Res

PubMed ID: 36533523

Doi: 10.1093/nar/gkac1179

Products & Services: Recombinant Proteins

Improving adeno-associated viral (AAV) vector-mediated transgene expression in retinal ganglion cells: comparison of five promoters

Authors: Bart Nieuwenhuis, Elise Laperrousaz, James R Tribble, Joost Verhaagen, James W Fawcett, Keith R Martin, Pete A Williams, Andrew Osborne

Journal: Gene Ther

PubMed ID: 36635457

Doi: 10.1038/s41434-022-00380-z

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Highly efficient and robust π-FISH rainbow for multiplexed in situ detection of diverse biomolecules

Authors: Yingfeng Tao, Xiaoliu Zhou, Leqiang Sun, Da Lin, Huaiyuan Cai, Xi Chen, Wei Zhou, Bing Yang, Zhe Hu, Jing Yu, Jing Zhang, Xiaoqing Yang, Fang Yang, Bang Shen, Wenbao Qi, Zhenfang Fu, Jinxia Dai, Gang Cao

Journal: Nat Commun

PubMed ID: 36707540

Doi: 10.1038/s41467-023-36137-4

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A soluble TLR5 is involved in PBLs activation and antibacterial immunity via TLR5M-MyD88-signaling pathway in tongue sole Cynoglossus semilaevis

Authors: Ji-Xing Feng, Ling Liu, Hong-Ye Wang, Jian Zhang, Xue-Peng Li

Journal: Int J Biol Macromol

PubMed ID: 36634796

Doi: 10.1016/j.ijbiomac.2023.123208

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Diagnostic performance between in-house and commercial SARS-CoV-2 serological immunoassays including binding-specific antibody and surrogate virus neutralization test (sVNT)

Authors: Poramed Winichakoon, Jiraprapa Wipasa, Kriangkrai Chawansuntati, Parichat Salee, Tavitiya Sudjaritruk, Saowaluck Yasri, Chantana Khamwan, Rungnapa Peerakam, Dararat Dankai, Romanee Chaiwarith

Journal: Sci Rep

PubMed ID: 36593231

Doi: 10.1038/s41598-022-26202-1

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Enhancer architecture and chromatin accessibility constrain phenotypic space during Drosophila development

Authors: Rafael Galupa, Gilberto Alvarez-Canale, Noa Ottilie Borst, Timothy Fuqua, Lautaro Gandara, Natalia Misunou, Kerstin Richter, Mariana R P Alves, Esther Karumbi, Melinda Liu Perkins, Tin Kocjan, Christine A Rushlow, Justin Crocker

Journal: Dev Cell

PubMed ID: 36626871

Doi: 10.1016/j.devcel.2022.12.003

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YAP1 suppression inhibits autophagy and improves the efficacy of anti-PD-1 immunotherapy in hepatocellular carcinoma

Authors: Yuting Gao, Qing Peng, Shenghao Li, Kangning Zheng, Yi Gong, Yu Xue, Yiwei Liu, Junlan Lu, Yuman Zhang, Xinli Shi

Journal: Exp Cell Res

PubMed ID: 36693491

Doi: 10.1016/j.yexcr.2023.113486

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Author Correction: Structure basis for inhibition of SARS-CoV-2 by the feline drug GC376

Authors: Xiao-Dong Luan, Bin-Xian Chen, Wei-Juan Shang, Wan-Chao Yin, Ye Jin, Lei-Ke Zhang, H Eric Xu, Shu-Yang Zhang

Journal: Acta Pharmacol Sin

PubMed ID: 35948753

Doi: 10.1038/s41401-022-00964-w

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An iterative gene-editing strategy broadens eIF4E1 genetic diversity in Solanum lycopersicum and generates resistance to multiple potyvirus isolates

Authors: Kyoka Kuroiwa, Benoit Danilo, Laura Perrot, Christina Thenault, Florian Veillet, Fabien Delacote, Philippe Duchateau, Fabien Nogué, Marianne Mazier, Jean-Luc Gallois

Journal: Plant Biotechnol J

PubMed ID: 36715107

Doi: 10.1111/pbi.14003

Products & Services: Protein and Antibody Isolation

The pseudokinase NRBP1 activates Rac1/Cdc42 via P-Rex1 to drive oncogenic signalling in triple-negative breast cancer

Authors: Xue Yang, Miguel I Cruz, Elizabeth V Nguyen, Cheng Huang, Ralf B Schittenhelm, Jennii Luu, Karla J Cowley, Sung-Young Shin, Lan K Nguyen, Terry C C Lim Kam Sian, Kimberley C Clark, Kaylene J Simpson, Xiuquan Ma, Roger J Daly

Journal: Oncogene

PubMed ID: 36693952

Doi: 10.1038/s41388-023-02594-w

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