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Single-cell resolution reveals RalA GTPase expanding hematopoietic stem cells and facilitating of BCR-ABL1-driven leukemogenesis in a CRISPR/Cas9 gene editing mouse model

Authors: Zhao Yin, Rui Su, Lanlan Ge, Xiuyuan Wang, Juhua Yang, Guiping Huang, Chuting Li, Yanjun Liu, Keda Zhang, Lan Deng, Jia Fei

Journal: International journal of biological sciences

PubMed ID: 36923939

Doi: 10.7150/ijbs.76993

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Loss of LGR4/GPR48 causes severe neonatal salt wasting due to disrupted WNT signaling altering adrenal zonation

Authors: Cécily Lucas, Kay-Sara Sauter, Michael Steigert, Delphine Mallet, James Wilmouth, Julie Olabe, Ingrid Plotton, Yves Morel, Daniel Aeberli, Franca Wagner, Hans Clevers, Amit V Pandey, Pierre Val, Florence Roucher-Boulez, Christa E Flück

Journal: JOURNAL OF CLINICAL INVESTIGATION

PubMed ID: 36538378

Doi: 10.1172/JCI164915

Products & Services: Protein and Antibody Isolation

MTORC2 is a physiological hydrophobic motif kinase of S6 Kinase 1

Authors: Sheikh Tahir Majeed, Rabiya Majeed, Aijaz A Malik, Khurshid Iqbal Andrabi

Journal: Biochim Biophys Acta Mol Cell Res

PubMed ID: 36858209

Doi: 10.1016/j.bbamcr.2023.119449

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A Physiologically Responsive Nanocomposite Hydrogel for Treatment of Head and Neck Squamous Cell Carcinoma via Proteolysis-Targeting Chimeras Enhanced Immunotherapy

Authors: Yaping Wu, Xiaowei Chang, Guizhu Yang, Li Chen, Qi Wu, Jiamin Gao, Ran Tian, Wenyun Mu, John Justin Gooding, Xin Chen, Shuyang Sun

Journal: Adv Mater

PubMed ID: 36656993

Doi: 10.1002/adma.202210787

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Revealing the role of tunable amino acid residues in elastin-like polypeptides (ELPs)-mediated biomimetic silicification

Authors: Yue Qiu , Yuanqing Lin , Bo Zeng , Peiliang Qin , Zhiwei Yi , Guangya Zhang

Journal: Int J Biol Macromol

PubMed ID: 36539170

Doi: 10.1016/j.ijbiomac.2022.12.152

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Multi-omic screening of invasive GBM cells in engineered biomaterials and patient biopsies reveals targetable transsulfuration pathway alterations

Authors: Joseph H Garcia, Erin A Akins, Saket Jain, Kayla J Wolf, Jason Zhang, Nikita Choudhary, Meeki Lad, Poojan Shukla, Sabraj Gill, Will Carson, Luis Carette, Allison Zheng, Sanjay Kumar, Manish K Aghi

Journal: biorxiv

PubMed ID: 36865128

Doi: 10.1101/2023.02.23.529575

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SARS-CoV-2 Main Protease Targets Host Selenoproteins and Glutathione Biosynthesis for Knockdown via Proteolysis, Potentially Disrupting the Thioredoxin and Glutaredoxin Redox Cycles

Authors: Ignacio A Gallardo, Daniel A Todd, Stella T Lima, Jonathan R Chekan, Norman H Chiu, Ethan Will Taylor

Journal: Antioxidants (Basel)

PubMed ID: 36978807

Doi: 10.3390/antiox12030559

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Heteromultivalent scaffolds fabricated by biomimetic co-assembly of DNA-RNA building blocks for the multi-analysis of miRNAs

Authors: Chengjie Duan, Yan Chen, Zhiqiang Hou, Dayong Li, Jin Jiao, Weihao Sun, Yang Xiang

Journal: J Mater Chem B

PubMed ID: 36723144

Doi: 10.1039/d2tb02663e

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Phosphorylation of TRF2 promotes its interaction with TIN2 and regulates DNA damage response at telomeres

Authors: Radka Storchova, Matous Palek, Natalie Palkova, Pavel Veverka, Tomas Brom, Ctirad Hofr, Libor Macurek

Journal: Nucleic Acids Res

PubMed ID: 36651296

Doi: 10.1093/nar/gkac1269

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Microenvironment-responsive anti-PD-L1 × CD3 bispecific T-cell engager for solid tumor immunotherapy

Authors: Dingkang Liu, Lichen Bao, Haichao Zhu, Yali Yue, Jing Tian, Xiangdong Gao, Jun Yin

Journal: Journal of controlled release

PubMed ID: 36669532

Doi: 10.1016/j.jconrel.2023.01.041

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Suppression of Tumor or Host Intrinsic CMTM6 Drives Antitumor Cytotoxicity in a PD-L1–Independent Manner

Authors: Yiru Long , Runqiu Chen , Xiaolu Yu , Yongliang Tong , Xionghua Peng , Fanglin Li , Chao Hu, Jianhua Sun , Likun Gong

Journal: Cancer Immunol Res .

PubMed ID: 36484740

Doi: 10.1158/2326-6066.CIR-22-0439

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A natriuretic peptide molecule from Vigna angularis, VaEG45, confers rust resistance by inhibiting fungal development

Authors: Weina Sun , Mengqi Yuan , Lihua Yin , Xiwang Ke , Yuhu Zuo

Journal: Plant Cell Rep .

PubMed ID: 36576553

Doi: 10.1007/s00299-022-02967-7

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Room-temperature structural studies of SARS-CoV-2 protein NendoU with an X-ray free-electron laser

Authors: Rebecca J Jernigan , Dhenugen Logeswaran , Diandra Doppler , Nirupa Nagaratnam , Mukul Sonker , Jay-How Yang , Gihan Ketawala , Jose M Martin-Garcia , Megan L Shelby , Thomas D Grant , Valerio Mariani , Alexandra Tolstikova , Michelle Z Sheikh , Mimi Cho Yung , Matthew A Coleman , Sahba Zaare , Emily K Kaschner , Mohammad Towshif Rabbani , Reza Nazari , Michele A Zacks , Brandon Hayes , Raymond G Sierra , Mark S Hunter , Stella Lisova , Alexander Batyuk , Christopher Kupitz , Sebastien Boutet , Debra T Hansen , Richard A Kirian , Marius Schmidt , Raimund Fromme , Matthias Frank , Alexandra Ros , Julian J-L Chen , Sabine Botha , Petra Fromme

Journal: Structure.

PubMed ID: 36630960

Doi: 10.1016/j.str.2022.12.009

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Enhancement of Cell Adhesion by Nucleolin-Interacting Protein AFAP

Authors: Hongcheng Tang, Daxiu Zhang, Fenfen Jiang, Lifeng Yu, Hui Tang, Jiafeng Zhu, Shuyan Wu, Hua Niu

Journal: J Pers Med

PubMed ID: 36836536

Doi: 10.3390/jpm13020302

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Actin polymerisation and crosslinking drive left-right asymmetry in single cell and cell collectives

Authors: Yee Han Tee, Wei Jia Goh, Xianbin Yong, Hui Ting Ong, Jinrong Hu, Ignacius Yan Yun Tay, Shidong Shi, Salma Jalal, Samuel F H Barnett, Pakorn Kanchanawong, Wenmao Huang, Jie Yan, Yong Ann Ben Lim, Visalatchi Thiagarajan, Alex Mogilner, Alexander D Bershadsky

Journal: Nat Commun

PubMed ID: 36774346

Doi: 10.1038/s41467-023-35918-1

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Establishment and validation of a plasma oncofetal chondroitin sulfated proteoglycan for pan-cancer detection

Authors: Pei-Fen Zhang, Zi-Yi Wu, Wen-Bin Zhang, Yong-Qiao He, Kexin Chen, Tong-Min Wang, Haixin Li, Hong Zheng, Dan-Hua Li, Da-Wei Yang, Ting Zhou, Chang-Mi Deng, Ying Liao, Wen-Qiong Xue, Lian-Jing Cao, Xi-Zhao Li, Jiang-Bo Zhang, Si-Qi Dong, Fang Wang, Mei-Qi Zheng, Wen-Li Zhang, Jianbing Mu, Wei-Hua Jia

Journal: Nat Commun

PubMed ID: 36746966

Doi: 10.1038/s41467-023-36374-7

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Cholesterol esters form supercooled lipid droplets whose nucleation is facilitated by triacylglycerols

Authors: Calvin Dumesnil, Lauri Vanharanta, Xavier Prasanna, Mohyeddine Omrane, Maxime Carpentier, Apoorva Bhapkar, Giray Enkavi, Veijo T Salo, Ilpo Vattulainen, Elina Ikonen, Abdou Rachid Thiam

Journal: Nat Commun

PubMed ID: 36807572

Doi: 10.1038/s41467-023-36375-6

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Functional analysis of 110 phosphorylation sites on the circadian clock protein FRQ identifies clusters determining period length and temperature compensation

Authors: Bin Wang, Elizabeth-Lauren Stevenson, Jay C Dunlap

Journal: G3 (Bethesda)

PubMed ID: 36537198

Doi: 10.1093/g3journal/jkac334

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A cercarial invadolysin interferes with the host immune response and facilitates infection establishment of Schistosoma mansoni

Authors: Jacob R Hambrook, Patrick C Hanington

Journal: PLoS Pathog

PubMed ID: 36730464

Doi: 10.1371/journal.ppat.1010884

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FUNDC1 interacts with GPx4 to govern hepatic ferroptosis and fibrotic injury through a mitophagy-dependent manner

Authors: Yaguang Bi, Shuolin Liu, Xing Qin, Miyesaier Abudureyimu, Lu Wang, Rongjun Zou, Amir Ajoolabady, Wenjing Zhang, Hu Peng, Jun Ren, Yingmei Zhang

Journal: J Adv Res

PubMed ID: 36828120

Doi: 10.1016/j.jare.2023.02.012

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Time-Course Transcriptome Profiling Reveals Differential Resistance Responses of Tomato to a Phytotoxic Effector of the Pathogenic Oomycete

Authors: Xue Zhou, Ke Wen, Shen-Xin Huang, Yi Lu, Yang Liu, Jing-Hao Jin, Shiv D Kale, Xiao-Ren Chen

Journal: Plants (Basel)

PubMed ID: 36840230

Doi: 10.3390/plants12040883

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How Many Sirtuin Genes Are Out There? Evolution of Sirtuin Genes in Vertebrates With a Description of a New Family Member

Authors: Juan C Opazo, Michael W Vandewege, Federico G Hoffmann, Kattina Zavala, Catalina Meléndez, Charlotte Luchsinger, Viviana A Cavieres, Luis Vargas-Chacoff, Francisco J Morera, Patricia V Burgos, Cheril Tapia-Rojas, Gonzalo A Mardones

Journal: Mol Biol Evol

PubMed ID: 36656997

Doi: 10.1093/molbev/msad014

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Antagonism between Prdm16 and Smad4 specifies the trajectory and progression of pancreatic cancer

Authors: Eric Hurwitz, Parash Parajuli, Seval Ozkan, Celine Prunier, Thien Ly Nguyen, Deanna Campbell, Creighton Friend, Allyn Austin Bryan, Ting-Xuan Lu, Steven Christopher Smith, Mohammed Shawkat Razzaque, Keli Xu, Azeddine Atfi

Journal: J Cell Biol

PubMed ID: 36828547

Doi: 10.1083/jcb.202203036

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Crystallographic data of an importin-α3 dimer in which the two protomers are bridged by a bipartite nuclear localization signal

Authors:

Journal: Data Brief

PubMed ID: 36875212

Doi: 10.1016/j.dib.2023.108988

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Stress-induced plasticity of a CRH/GABA projection disrupts reward behaviors in mice

Authors: Matthew T Birnie, Annabel K Short, Gregory B de Carvalho, Lara Taniguchi, Benjamin G Gunn, Aidan L Pham, Christy A Itoga, Xiangmin Xu, Lulu Y Chen, Stephen V Mahler, Yuncai Chen, Tallie Z Baram

Journal: Nat Commun

PubMed ID: 36841826

Doi: 10.1038/s41467-023-36780-x

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Chikungunya Virus and Its Envelope Protein E2 Induce Hyperalgesia in Mice: Inhibition by Anti-E2 Monoclonal Antibodies and by Targeting TRPV1

Authors: Carina Z Segato-Vendrameto, Camila Zanluca, Amanda Z Zucoloto, Tiago H Zaninelli, Mariana M Bertozzi, Telma Saraiva-Santos, Camila R Ferraz, Larissa Staurengo-Ferrari, Stephanie Badaro-Garcia, Marília F Manchope, Amanda M Dionisio, Felipe A Pinho-Ribeiro, Sergio M Borghi, Ana Luiza Pamplona Mosimann, Rubia Casagrande, Juliano Bordignon, Victor Fattori, Claudia N Duarte Dos Santos, Waldiceu A Verri

Journal: Cells

PubMed ID: 36831223

Doi: 10.3390/cells12040556

Products & Services: Codon Optimization

Retinoblastoma Expression and Targeting by CDK4/6 Inhibitors in Small Cell Lung Cancer

Authors: Gary Wildey, Ashley M Shay, Karen S McColl, Suzy Yoon, Mohammad A Shatat, Ahmad Perwez, Kyle B Spainhower, Adam M Kresak, MaryBeth Lipka, Michael Yang, Mohadese Behtaj, Pingfu Fu, Asrar Alahmadi, Wadad Mneimneh, Ata Abbas, Afshin Dowlati

Journal: Mol Cancer Ther

PubMed ID: 36399634

Doi: 10.1158/1535-7163.MCT-22-0365

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Xeno interactions between MHC-I proteins and molecular chaperones enable ligand exchange on a broad repertoire of HLA allotypes

Authors: Yi Sun, Georgia F Papadaki, Christine A Devlin, Julia N Danon, Michael C Young, Trenton J Winters, George M Burslem, Erik Procko, Nikolaos G Sgourakis

Journal: Sci Adv

PubMed ID: 36827371

Doi: 10.1126/sciadv.ade7151

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Selective excitation with recoupling pulse schemes uncover properties of disordered mineral phases in bone-like apatite grown with bone proteins

Authors: Irina Matlahov, Alexey Kulpanovich, Taly Iline-Vul, Merav Nadav-Tsubery, Gil Goobes

Journal: Solid State Nucl Magn Reson

PubMed ID: 36913847

Doi: 10.1016/j.ssnmr.2023.101860

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Gestational palmitic acid suppresses embryonic GATA-binding protein 4 signaling and causes congenital heart disease

Authors: Rui Zhao, Li Cao, Wen-Jun Gu, Lei Li, Zhong-Zhong Chen, Jie Xiang, Ze-Yu Zhou, Bo Xu, Wei-Dong Zang, Xiang-Yu Zhou, Jing Cao, Kun Sun, Jian-Yuan Zhao

Journal: Cell Rep Med

PubMed ID: 36809766

Doi: 10.1016/j.xcrm.2023.100953

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Exploring the Expression and Function of cTyro3, a Candidate Zika Virus Receptor, in the Embryonic Chicken Brain and Inner Ear

Authors: Vashi Negi, Richard J Kuhn, Donna M Fekete

Journal: Viruses

PubMed ID: 36680287

Doi: 10.3390/v15010247

Products & Services: Protein and Antibody Isolation

Polymorphic Alpha-Synuclein Oligomers: Characterization and Differential Detection with Novel Corresponding Antibodies

Authors: Kenya Moore, Urmi Sengupta, Nicha Puangmalai, Nemil Bhatt, Rakez Kayed

Journal: Mol Neurobiol

PubMed ID: 36707462

Doi: 10.1007/s12035-023-03211-3

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Exploiting natural riboswitches for aptamer engineering and validation

Authors: Michael G Mohsen, Matthew K Midy, Aparaajita Balaji, Ronald R Breaker

Journal: Nucleic Acids Res

PubMed ID: 36617976

Doi: 10.1093/nar/gkac1218

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Dependency of sanitation infrastructure on the discharge of faecal coliform and SARS-CoV-2 viral RNA in wastewater from COVID and non-COVID hospitals in Dhaka, Bangladesh

Authors: Nuhu Amin, Rehnuma Haque, Md Ziaur Rahman, Mohammed Ziaur Rahman, Zahid Hayat Mahmud, Rezaul Hasan, Md Tahmidul Islam, Protim Sarker, Supriya Sarker, Shaikh Daud Adnan, Nargis Akter, Dara Johnston, Mahbubur Rahman, Pengbo Liu, Yuke Wang, Tahmina Shirin, Mahbubur Rahman, Prosun Bhattacharya

Journal: Sci Total Environ

PubMed ID: 36623655

Doi: 10.1016/j.scitotenv.2023.161424

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Autoinhibitory structure of preligand association state implicates a new strategy to attain effective DR5 receptor activation

Authors: Gang Du, Linlin Zhao, Yumei Zheng, Anissa Belfetmi, Tiantian Cai, Boying Xu, Karen Heyninck, Kim Van Den Heede, Marie-Ange Buyse, Pietro Fontana, Michael Bowman, Lih-Ling Lin, Hao Wu, James Jeiwen Chou

Journal: Cell Res

PubMed ID: 36604598

Doi: 10.1038/s41422-022-00755-2

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Monosynaptic restriction of the anterograde herpes simplex virus strain H129 for neural circuit tracing

Authors: Kyle B Fischer, Hannah K Collins, Yan Pang, Dheeraj S Roy, Ying Zhang, Guoping Feng, Shu-Jing Li, Adam Kepecs, Edward M Callaway

Journal: J Comp Neurol

PubMed ID: 36606699

Doi: 10.1002/cne.25451

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Evaluation of a biotin-based surrogate virus neutralization test for detecting postvaccination antibodies against SARS-CoV-2 variants in sera

Authors: Min-Ju Ahn, Jung-Ah Kang, Su Min Hong, Kyu-Sun Lee, Dong Ho Kim, Daesub Song, Dae Gwin Jeong

Journal: Biochem Biophys Res Commun

PubMed ID: 36696754

Doi: 10.1016/j.bbrc.2023.01.052

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Vaccination with S, an antigen guided by SARS-CoV-2 S protein evolution, protects against challenge with viral variants in mice

Authors: Yongliang Zhao, Wenjia Ni, Simeng Liang, Lianghui Dong, Min Xiang, Zeng Cai, Danping Niu, Qiuhan Zhang, Dehe Wang, Yucheng Zheng, Zhen Zhang, Dan Zhou, Wenhua Guo, Yongbing Pan, Xiaoli Wu, Yimin Yang, Zhaofei Jing, Yongzhong Jiang, Yu Chen, Huan Yan, Yu Zhou, Ke Xu, Ke Lan

Journal: Sci Transl Med

PubMed ID: 36599007

Doi: 10.1126/scitranslmed.abo3332

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Nanocell COVID-19 vaccine triggers a novel immune response pathway producing high-affinity antibodies which neutralize all variants of concern

Authors: Steven Y Gao, Nancy B Amaro-Mugridge, Jocelyn Madrid-Weiss, Nikolina Petkovic, Natasha Vanegas, Kumar Visvanathan, Bryan R G Williams, Jennifer A MacDiarmid, Himanshu Brahmbhatt

Journal: Front Immunol

PubMed ID: 36818474

Doi: 10.3389/fimmu.2022.1038562

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Detection and Molecular Characterization of the SARS-CoV-2 Delta Variant and the Specific Immune Response in Companion Animals in Switzerland

Authors: Evelyn Kuhlmeier, Tatjana Chan, Cecilia Valenzuela Agüí, Barbara Willi, Aline Wolfensberger, Christian Beisel, Ivan Topolsky, Niko Beerenwinkel, Tanja Stadler, Sarah Jones, Grace Tyson, Margaret J Hosie, Katja Reitt, Julia Hüttl, Marina L Meli, Regina Hofmann-Lehmann

Journal: Viruses

PubMed ID: 36680285

Doi: 10.3390/v15010245

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Calmodulin variants associated with congenital arrhythmia impair selectivity for ryanodine receptors

Authors: Giuditta Dal Cortivo, Valerio Marino, Silvia Bianconi, Daniele Dell'Orco

Journal: Front Mol Biosci

PubMed ID: 36685279

Doi: 10.3389/fmolb.2022.1100992

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Defending against SARS-CoV-2: The T cell perspective

Authors: Patricia Almendro-Vázquez, Rocío Laguna-Goya, Estela Paz-Artal

Journal: Front Immunol

PubMed ID: 36776863

Doi: 10.3389/fimmu.2023.1107803

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Engineering human stem cell-derived islets to evade immune rejection and promote localized immune tolerance

Authors: Dario Gerace, Quan Zhou, Jennifer Hyoje-Ryu Kenty, Adrian Veres, Elad Sintov, Xi Wang, Kyle R Boulanger, Hongfei Li, Douglas A Melton

Journal: Cell Rep Med

PubMed ID: 36599351

Doi: 10.1016/j.xcrm.2022.100879

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Low-cost and prototype-friendly method for biocompatible encapsulation of implantable electronics with epoxy overmolding, hermetic feedthroughs and P3HT coating

Authors: Marek Novák, Jozef Rosina, Hana Bendová, Kristina Kejlová, Alena Vlková, Marian Rucki, Lada Svobodová, Robert Gürlich, Jan Hajer

Journal: Sci Rep

PubMed ID: 36717683

Doi: 10.1038/s41598-023-28699-6

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Subunit Vaccine Targeting Phosphate ABC Transporter ATP-Binding Protein, PstB, Provides Cross-Protection against Serotype 2, 7, and 9 in Mice

Authors: Zujie Yan, Xiaohui Yao, Ruyi Pan, Junjie Zhang, Xiaochun Ma, Nihua Dong, Jianchao Wei, Ke Liu, Yafeng Qiu, Katie Sealey, Hester Nichols, Michael A Jarvis, Mathew Upton, Xiangdong Li, Zhiyong Ma, Juxiang Liu, Beibei Li

Journal: Vet Sci

PubMed ID: 36669049

Doi: 10.3390/vetsci10010048

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A single high-dose irradiation changes accumulation of methotrexate and gene expression levels of SLC and ABC transporters in cancer cells

Authors: Kakeru Sato, Tatsuya Seki, Asuka Mizutani, Yuka Muranaka, Shiho Hirota, Kodai Nishi, Kana Yamazaki, Ryuichi Nishii, Takeo Nakanishi, Ikumi Tamai, Keiichi Kawai, Masato Kobayashi

Journal: Front Pharmacol

PubMed ID: 36712667

Doi: 10.3389/fphar.2022.1069321

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A non-toxic recombinant bivalent chimeric protein rETXCSA as a potential vaccine candidate against enterotoxemia and braxy

Authors: Jige Du, Bo Liu, Tuanjie Wang, Zhen Zhu, Chunsheng Yin, Yufeng Luo, Ying Liu, Xiaoyun Chen

Journal: Vaccine

PubMed ID: 36635138

Doi: 10.1016/j.vaccine.2022.11.021

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Omicron variants breakthrough infection elicited higher specific memory immunity than third dose booster in healthy vaccinees

Authors: Pei Yu, Zijian Liu, Zhuoqi Zhu, Jiaqing Yang, Min Deng, Mingxiao Chen, Changchun Lai, Weiya Kong, Shilong Xiong, Li Wan, Weikang Mai, Lu Chen, Yu Lei, Shahzad Akbar Khan, Jianfeng Ruan, An Kang, Xuguang Guo, Qiang Zhou, Wenrui Li, Zheng Chen, Yuemei Liang, Pingchao Li, Lei Zhang, Tianxing Ji

Journal: Virol Sin

PubMed ID: 36603767

Doi: 10.1016/j.virs.2022.12.008

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Transcriptomic exploration of the Coleopteran wings reveals insight into the evolution of novel structures associated with the beetle elytron

Authors: David M Linz, Yuichiro Hara, Kevin D Deem, Shigehiro Kuraku, Shigeo Hayashi, Yoshinori Tomoyasu

Journal: J Exp Zool B Mol Dev Evol

PubMed ID: 36617687

Doi: 10.1002/jez.b.23188

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Depletion of microglial BDNF increases susceptibility to the behavioral and synaptic effects of chronic unpredictable stress

Authors: Samuel C Woodburn, Helina S Asrat, James K Flurer, Hana C Schwierling, Justin L Bollinger, Lauren L Vollmer, Eric S Wohleb

Journal: Brain Behav Immun

PubMed ID: 36681359

Doi: 10.1016/j.bbi.2023.01.014

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