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Tumor-Localized Administration of α-GalCer to Recruit Invariant Natural Killer T Cells and Enhance Their Antitumor Activity against Solid Tumors

Authors: Yan-Ruide Li, Yang Zhou, Matthew Wilson, Adam Kramer, Ryan Hon, Yichen Zhu, Ying Fang, Lili Yang

Journal: Int J Mol Sci

PubMed ID: 35886891

Doi: 10.3390/ijms23147547

Products & Services: Recombinant Proteins

Replicating RNA vaccination elicits an unexpected immune response that efficiently protects mice against lethal Crimean-Congo hemorrhagic fever virus challenge

Authors: Shanna S Leventhal, Kimberly Meade-White, Deepashri Rao, Elaine Haddock, Jacqueline Leung, Dana Scott, Jacob Archer, Samantha Randall, Jesse H Erasmus, Heinz Feldmann, David W Hawman

Journal: EBioMedicine

PubMed ID: 35907368

Doi: 10.1016/j.ebiom.2022.104188

Products & Services: Peptide Synthesis

Development of Melioidosis Subunit Vaccines Using an Enzymatically Inactive Burkholderia pseudomallei AhpC

Authors: Lindsey K Schmidt, Caitlyn E Orne, Teresa L Shaffer, Shane M Wilson, Nittaya Khakhum, Alfredo G Torres, Paul J Brett, Mary N Burtnick

Journal: Infect Immun

PubMed ID: 35862715

Doi: 10.1128/iai.00222-22

Products & Services: Proteins, Expression, Isolation and Analysis

The Patterning and Proportion of Charged Residues in the Arginine-Rich Mixed-Charge Domain Determine the Membrane-Less Organelle Targeted by the Protein

Authors: Tamami Miyagi, Rio Yamazaki, Koji Ueda, Satoshi Narumi, Yuhei Hayamizu, Hiroshi Uji-I, Masahiko Kuroda, Kohsuke Kanekura

Journal: Int J Mol Sci

PubMed ID: 35887012

Doi: 10.3390/ijms23147658

Products & Services: Bacterial Expression

Discovery of a First-in-Class Degrader for Nuclear Receptor Binding SET Domain Protein 2 (NSD2) and Ikaros/Aiolos

Authors: Fanye Meng, Chenxi Xu, Kwang-Su Park, H Ümit Kaniskan, Gang Greg Wang, Jian Jin

Journal: J Med Chem

PubMed ID: 35895319

Doi: 10.1021/acs.jmedchem.2c00807

Products & Services: Plasmid DNA Preparation

Development and characterization of an inducible assay system to measure Zika virus capsid interactions

Authors: Jieshi Yu, Chen Huang, Zhao Wang, Radhey S Kaushik, Zizhang Sheng, Feng Li, Dan Wang

Journal: J Med Virol

PubMed ID: 35822280

Doi: 10.1002/jmv.27991

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SARS-CoV-2 Omicron escapes mRNA vaccine booster-induced antibody neutralisation in patients with autoimmune rheumatic diseases: an observational cohort study

Authors: Woo-Joong Kim, Seong-Ho Choi, Ji Young Park, Jung Soo Song, Jin-Won Chung, Sang Tae Choi

Journal: Ann Rheum Dis

PubMed ID: 35878999

Doi: 10.1136/ard-2022-222689

Bacteria deplete deoxynucleotides to defend against bacteriophage infection

Authors: Nitzan Tal, Adi Millman, Avigail Stokar-Avihail, Taya Fedorenko, Azita Leavitt, Sarah Melamed, Erez Yirmiya, Carmel Avraham, Alexander Brandis, Tevie Mehlman, Gil Amitai, Rotem Sorek

Journal: Nat Microbiol

PubMed ID: 35817891

Doi: 10.1038/s41564-022-01158-0

Products & Services: PCR Cloning and Subcloning

RG203KR Mutations in SARS-CoV-2 Nucleocapsid: Assessing the Impact Using a Virus-Like Particle Model System

Authors: Harsha Raheja, Soma Das, Anindita Banerjee, Dikshaya P, Deepika C, Debanjan Mukhopadhyay, Subbaraya G Ramachandra, Saumitra Das

Journal: Microbiol Spectr

PubMed ID: 35862952

Doi: 10.1128/spectrum.00781-22

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Development of an in-house quantitative ELISA for the evaluation of different Covid-19 vaccines in humans

Authors: Mariem Gdoura, Fatma Ben Ghaloum, Meriem Ben Hamida, Wafa Chamsa, Henda Triki, Chokri Bahloul

Journal: Sci Rep

PubMed ID: 35788676

Doi: 10.1038/s41598-022-15378-1

In situ architecture of the lipid transport protein VPS13C at ER-lysosome membrane contacts

Authors: Shujun Cai, Yumei Wu, Andrés Guillén-Samander, William Hancock-Cerutti, Jun Liu, Pietro De Camilli

Journal: Proc Natl Acad Sci U S A

PubMed ID: 35858323

Doi: 10.1073/pnas.2203769119

Products & Services: Mutant Libraries

Immunogenicity of the third and fourth BNT162b2 mRNA COVID-19 boosters and factors associated with immune response in patients with SLE and rheumatoid arthritis

Authors: Theerada Assawasaksakul, Seelwan Sathitratanacheewin, Preeyaporn Vichaiwattana, Nasamon Wanlapakorn, Yong Poovorawan, Yingyos Avihingsanon, Nawaporn Assawasaksakul, Wonngarm Kittanamongkolchai

Journal: Lupus Sci Med

PubMed ID: 35902168

Doi: 10.1136/lupus-2022-000726

HOXB5-activated ANGPT2 promotes the proliferation, migration, invasion and angiogenic effect of esophageal cancer cells via activating ERK/AKT signaling pathway

Authors: Jing Li, Shanshan Gao

Journal: Exp Ther Med

PubMed ID: 35949323

Doi: 10.3892/etm.2022.11522

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The Relative Positioning of B and T Cell Epitopes Drives Immunodominance

Authors: Riccardo Biavasco, Marco De Giovanni

Journal: Vaccines (Basel)

PubMed ID: 36016115

Doi: 10.3390/vaccines10081227

Products & Services: Mammalian Expression

Crystal structure of human NADK2 reveals a dimeric organization and active site occlusion by lysine acetylation

Authors: Charline Mary, Mona Hoseini Soflaee, Rushendhiran Kesavan, Muriel Gelin, Harrison Brown, G Zacharias, Thomas P Mathews, Andrew Lemoff, Corinne Lionne, Gilles Labesse, Gerta Hoxhaj

Journal: Mol Cell

PubMed ID: 35868311

Doi: 10.1016/j.molcel.2022.06.026

Products & Services: Mammalian Expression

A Novel Cre/lox71-Based System for Inducible Expression of Recombinant Proteins and Genome Editing

Authors: Maxim Karagyaur, Daniyar Dyikanov, Pyotr Tyurin-Kuzmin, Stalik Dzhauari, Mariya Skryabina, Maksim Vigovskiy, Alexandra Primak, Natalia Kalinina, Vsevolod Tkachuk

Journal: Cells

PubMed ID: 35883584

Doi: 10.3390/cells11142141

Products & Services: Plasmid DNA Preparation

Circular RNA ROCK1, a novel circRNA, suppresses osteosarcoma proliferation and migration via altering the miR-532-5p/PTEN axis

Authors: Yize Liu, Guanzhen Qiu, Yinzhou Luo, Shanshan Li, Yeqiu Xu, Yuanzhuang Zhang, Jiayuan Hu, Peifeng Li, Hai Pan, Yong Wang

Journal: Exp Mol Med

PubMed ID: 35879346

Doi: 10.1038/s12276-022-00806-z

Products & Services: Mutant Libraries

Large-scale application of free energy perturbation calculations for antibody design

Authors: Fangqiang Zhu, Feliza A Bourguet, William F D Bennett, Edmond Y Lau, Kathryn T Arrildt, Brent W Segelke, Adam T Zemla, Thomas A Desautels, Daniel M Faissol

Journal: Sci Rep

PubMed ID: 35864134

Doi: 10.1038/s41598-022-14443-z

Products & Services: Catalog Antibody

Analysis of FR901379 Biosynthetic Genes in by Clustered Regularly Interspaced Short Palindromic Repeats/Cas9-Based Genomic Manipulation

Authors: Teng-Yun Wei, Yan Zheng, Miyang Wan, Songbai Yang, Jiawei Tang, Yuanjie Wu, Jiyang Li, Shao-Xin Chen

Journal: ACS Chem Biol

PubMed ID: 35822391

Doi: 10.1021/acschembio.2c00250

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Relaxin Affects Airway Remodeling Genes Expression through Various Signal Pathways Connected with Transcription Factors

Authors: Joanna Wieczfinska, Rafal Pawliczak

Journal: Int J Mol Sci

PubMed ID: 35955554

Doi: 10.3390/ijms23158413

Products & Services: Proteins, Expression, Isolation and Analysis

NK cell spatial dynamics and IgA responses in gut-associated lymphoid tissues during SIV infections

Authors: Philippe Rascle, Cyril Planchais, Béatrice Jacquelin, Marie Lazzerini, Vanessa Contreras, Caroline Passaes, Asier Saez-Cirion, Hugo Mouquet, Nicolas Huot, Michaela Müller-Trutwin

Journal: Commun Biol

PubMed ID: 35798936

Doi: 10.1038/s42003-022-03619-y

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Characterization of binding interactions of SARS-CoV-2 spike protein and DNA-peptide nanostructures

Authors: Marlen Kruse, Basma Altattan, Eva-Maria Laux, Nico Grasse, Lars Heinig, Christin Möser, David M Smith, Ralph Hölzel

Journal: Sci Rep

PubMed ID: 35896714

Doi: 10.1038/s41598-022-16914-9

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Intramuscular delivery of formulated RNA encoding six linked nanobodies is highly protective for exposures to three Botulinum neurotoxin serotypes

Authors: Jean Mukherjee, Celinia A Ondeck, Jacqueline M Tremblay, Jacob Archer, Michelle Debatis, Alexa Foss, Junya Awata, Jesse H Erasmus, Patrick M McNutt, Charles B Shoemaker

Journal: Sci Rep

PubMed ID: 35803998

Doi: 10.1038/s41598-022-15876-2

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Neutralizing antibody responses against SARS-CoV-2 in patients with plasma cell disorders who are on active treatment after two doses of mRNA vaccination

Authors: Al-Ola Abdallah, Zahra Mahmoudjafari, Tahani Atieh, Nausheen Ahmed, Wei Cui, Leyla Shune, Meera Mohan, Joseph McGuirk, Cassie Remker, Margaret Foss, Ellie Karloff, Heather Fitch, Shebli Atrash

Journal: Eur J Haematol

PubMed ID: 35810359

Doi: 10.1111/ejh.13826

Highly Effective Markerless Genetic Manipulation of Using a Mutated PheS-Based Counterselectable Marker

Authors: Guangjuan Gao, Dong Wei, Gang Li, Ping Chen, Liujun Wu, Siguo Liu, Yueling Zhang

Journal: Front Microbiol

PubMed ID: 35910605

Doi: 10.3389/fmicb.2022.947821

Products & Services: Peptide Synthesis

CryoEM of endogenous mammalian V-ATPase interacting with the TLDc protein mEAK-7

Authors: Yong Zi Tan, Yazan M Abbas, Jing Ze Wu, Di Wu, Kristine A Keon, Geoffrey G Hesketh, Stephanie A Bueler, Anne-Claude Gingras, Carol V Robinson, Sergio Grinstein, John L Rubinstein

Journal: Life Sci Alliance

PubMed ID: 35794005

Doi: 10.26508/lsa.202201527

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ArsR Family Regulator MSMEG_6762 Mediates the Programmed Cell Death by Regulating the Expression of HNH Nuclease in Mycobacteria

Authors: Xiangke Duan, Xue Huang, Junqi Xu, Xue Li, Jingjing Niu, Xiaoli Du, Xiaoyu Wang, Jiang Li, Michael Kelly, Jiaohan Guo, Ke Zhang, Yu Huang, Biao Kan, Jianping Xie

Journal: Microorganisms

PubMed ID: 36013953

Doi: 10.3390/microorganisms10081535

Products & Services: Proteins, Expression, Isolation and Analysis

Silencing lncRNA 93358 Inhibits the Apoptosis of Myocardial Cells in Myocardial Infarction Rats by Inducing the Expression of SLC8A1

Authors: Jiumei Cai, Xiaoping Wang, Wei Liao, Yiming Zhong, Lingling Chen, Zhiwei Zhang

Journal: Biomed Res Int

PubMed ID: 35845941

Doi: 10.1155/2022/1138709

Products & Services: Gene Synthesis

Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism

Authors: Yong-Gang Chang, Christopher J Lupton, Charles Bayly-Jones, Alastair C Keen, Laura D'Andrea, Christina M Lucato, Joel R Steele, Hari Venugopal, Ralf B Schittenhelm, James C Whisstock, Michelle L Halls, Andrew M Ellisdon

Journal: Nat Struct Mol Biol

PubMed ID: 35864164

Doi: 10.1038/s41594-022-00804-9

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Diminished T-cell immune responses to SARS-CoV-2 omicron variant after BNT162b2 vaccination

Authors: Stanley C Jordan, Bong-Ha Shin, Edgar Rodriguez, Ashley Vo, Ruan Zhang

Journal: Immunol Lett

PubMed ID: 35843362

Doi: 10.1016/j.imlet.2022.07.004

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CC chemokine receptor 5 antagonist alleviates inflammation by regulating IFN-γ/IL-10 and STAT4/Smad3 signaling in a mouse model of autoimmune encephalomyelitis

Authors: Sheikh F Ahmad, Ahmed Nadeem, Mushtaq A Ansari, Saleh A Bakheet, Mudassar Shahid, Haneen A Al-Mazroua, Homood M As Sobeai, Abdullah F Alasmari, Mohammed M Alanazi, Abdullah S Alhamed, Abdullah A Aldossari, Sabry M Attia

Journal: Cell Immunol

PubMed ID: 35872534

Doi: 10.1016/j.cellimm.2022.104580

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Intranasal administration of a live-attenuated recombinant newcastle disease virus expressing the SARS-CoV-2 Spike protein induces high neutralizing antibody levels and protects from experimental challenge infection in hamsters

Authors: Rik L de Swart, Olav S de Leeuw, Nadia Oreshkova, Nora M Gerhards, Irina C Albulescu, Sandra Vreman, José L Gonzales, Riks Maas, Frank J M van Kuppeveld, Peter Soema, Berend-Jan Bosch, Ben P H Peeters

Journal: Vaccine

PubMed ID: 35820941

Doi: 10.1016/j.vaccine.2022.07.005

Products & Services: Mammalian Expression

Persistent Reptarenavirus and Hartmanivirus Infection in Cultured Boid Cells

Authors: Annika Lintala, Leonora Szirovicza, Anja Kipar, Udo Hetzel, Jussi Hepojoki

Journal: Microbiol Spectr

PubMed ID: 35862992

Doi: 10.1128/spectrum.01585-22

Products & Services: Proteins, Expression, Isolation and Analysis

Characterization of Dense Granule Metalloproteinase INS-16 in

Authors: Hao Cui, Rui Xu, Yu Li, Yaqiong Guo, Ziding Zhang, Lihua Xiao, Yaoyu Feng, Na Li

Journal: Int J Mol Sci

PubMed ID: 35886965

Doi: 10.3390/ijms23147617

Products & Services: Proteins, Expression, Isolation and Analysis

Translating a Thin-Film Rehydration Method to Microfluidics for the Preparation of a SARS-CoV-2 DNA Vaccine: When Manufacturing Method Matters

Authors: Allegra Peletta, Eakachai Prompetchara, Kittipan Tharakhet, Papatsara Kaewpang, Supranee Buranapraditkun, Nongnaphat Yostrerat, Suwimon Manopwisedjaroen, Arunee Thitithanyanont, Jonathan Avaro, Leonard Krupnik, Antonia Neels, Kiat Ruxrungtham, Chutitorn Ketloy, Gerrit Borchard

Journal: Pharmaceutics

PubMed ID: 35890321

Doi: 10.3390/pharmaceutics14071427

Products & Services: Mammalian Expression

From functional genomics of vero cells to CRISPR-based genomic deletion for improved viral production rates

Authors: Marie-Angélique Sène, Yu Xia, Amine A Kamen

Journal: Biotechnol Bioeng

PubMed ID: 35869699

Doi: 10.1002/bit.28190

Products & Services: Molecular Biology Tools

Interaction of Liberibacter Solanacearum with Host Psyllid Vitellogenin and Its Association with Autophagy

Authors: Poulami Sarkar, Murad Ghanim

Journal: Microbiol Spectr

PubMed ID: 35863005

Doi: 10.1128/spectrum.01577-22

Products & Services: Proteins, Expression, Isolation and Analysis

Genetic diversity of collaborative cross mice enables identification of novel rift valley fever virus encephalitis model

Authors: Haley N Cartwright, Dominique J Barbeau, Joshua D Doyle, Ed Klein, Mark T Heise, Martin T Ferris, Anita K McElroy

Journal: PLoS Pathog

PubMed ID: 35834486

Doi: 10.1371/journal.ppat.1010649

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Peptide-siRNA nanoparticles targeting NF-κB p50 mitigate experimental abdominal aortic aneurysm progression and rupture

Authors: Huimin Yan, Ying Hu, Antonina Akk, Samuel A Wickline, Hua Pan, Christine T N Pham

Journal: Biomater Adv

PubMed ID: 35891603

Doi: 10.1016/j.bioadv.2022.213009

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Mucosal administration of a live attenuated recombinant COVID-19 vaccine protects nonhuman primates from SARS-CoV-2

Authors: Mariana F Tioni, Robert Jordan, Angie Silva Pena, Aditya Garg, Danlu Wu, Shannon I Phan, Christopher M Weiss, Xing Cheng, Jack Greenhouse, Tatyana Orekov, Daniel Valentin, Swagata Kar, Laurent Pessaint, Hanne Andersen, Christopher C Stobart, Melissa H Bloodworth, R Stokes Peebles, Yang Liu, Xuping Xie, Pei-Yong Shi, Martin L Moore, Roderick S Tang

Journal: npj Vaccines

PubMed ID: 35906244

Doi: 10.1038/s41541-022-00509-6

Products & Services: Proteins, Expression, Isolation and Analysis

Polymeric nanoparticles for dual-targeted theranostic gene delivery to hepatocellular carcinoma

Authors: Hannah J Vaughan, Camila G Zamboni, Laboni F Hassan, Nicholas P Radant, Desmond Jacob, Ronnie C Mease, Il Minn, Stephany Y Tzeng, Kathleen L Gabrielson, Pranshu Bhardwaj, Xin Guo, David Francisco, Martin G Pomper, Jordan J Green

Journal: Sci Adv

PubMed ID: 35857843

Doi: 10.1126/sciadv.abo6406

Products & Services: Gene Synthesis

Self-Masked Aldehyde Inhibitors of Human Cathepsin L Are Potent Anti-CoV-2 Agents

Authors: Jiyun Zhu, Linfeng Li, Aleksandra Drelich, Bala C Chenna, Drake M Mellott, Zane W Taylor, Vivian Tat, Christopher Z Garcia, Ardala Katzfuss, Chien-Te K Tseng, Thomas D Meek

Journal: Front Chem

PubMed ID: 35860632

Doi: 10.3389/fchem.2022.867928

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HJM-561, a Potent, Selective, and Orally Bioavailable EGFR PROTAC that Overcomes Osimertinib-Resistant EGFR Triple Mutations

Authors: Yong Du, Yongfeng Chen, Yuxia Wang, Jinju Chen, Xiaorong Lu, Li Zhang, Yan Li, Zhaofu Wang, Guozhong Ye, George Zhang

Journal: Mol Cancer Ther

PubMed ID: 35499406

Doi: 10.1158/1535-7163.MCT-21-0835

Products & Services: Proteins, Expression, Isolation and Analysis

Ligand-induced transmembrane conformational coupling in monomeric EGFR

Authors: Shwetha Srinivasan, Raju Regmi, Xingcheng Lin, Courtney A Dreyer, Xuyan Chen, Steven D Quinn, Wei He, Matthew A Coleman, Kermit L Carraway, Bin Zhang, Gabriela S Schlau-Cohen

Journal: Nat Commun

PubMed ID: 35794108

Doi: 10.1038/s41467-022-31299-z

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Erythroid lineage Jak2V617F expression promotes atherosclerosis through erythrophagocytosis and macrophage ferroptosis

Authors: Wenli Liu, Nataliya Östberg, Mustafa Yalcinkaya, Huijuan Dou, Kaori Endo-Umeda, Yang Tang, Xintong Hou, Tong Xiao, Trevor P Fidler, Sandra Abramowicz, Yong-Guang Yang, Oliver Soehnlein, Alan R Tall, Nan Wang

Journal: J Clin Invest

PubMed ID: 35587375

Doi: 10.1172/JCI155724

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Construction of a Novel Clinical Stage-Related Gene Signature for Predicting Outcome and Immune Response in Hepatocellular Carcinoma

Authors: Liu Yang, Long-Fei Zeng, Guo-Qing Hong, Qing Luo, Xing Lai

Journal: J Immunol Res

PubMed ID: 35865652

Doi: 10.1155/2022/6535009

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Apela gene therapy alleviates pulmonary hypertension in rats

Authors: Yuexin Hu, Liangli Jin, Yang Pan, Jue Zou, Zhi Wang

Journal: FASEB J

PubMed ID: 35747913

Doi: 10.1096/fj.202200266R

Products & Services: Plasmid DNA Preparation

Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain

Authors: Gamma Chi , Qiansheng Liang , Akshay Sridhar , John B Cowgill , Kasim Sader , Mazdak Radjainia , Pu Qian , Pablo Castro-Hartmann , Shayla Venkaya , Nanki Kaur Singh , Gavin McKinley , Alejandra Fernandez-Cid , Shubhashish M M Mukhopadhyay , Nicola A Burgess-Brown , Lucie Delemotte , Manuel Covarrubias , Katharina L Dürr

Journal: Nat Commun

PubMed ID: 35840580

Doi: 10.1038/s41467-022-29594-w

Products & Services: Plasmid DNA Preparation

Induction of Broadly Cross-Reactive Antibody Responses to SARS-CoV-2 Variants by S1 Nanoparticle Vaccines

Authors: Cong Sun , Run-Yu Yuan , Chu Xie , Jiu-Feng Sun , Xin-Yan Fang , Yi-Sha Hu , Xiao-Hui Yu, Zheng Liu , Mu-Sheng Zeng , Yin-Feng Kang

Journal: J Virol

PubMed ID: 35699445

Doi: 10.1128/jvi.00383-22

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A precise and efficient adenine base editor

Authors: Tianxiang Tu , Zongming Song , Xiaoyu Liu , Shengxing Wang , Xiaoxue He , Haitao Xi , Jiahua Wang , Tong Yan , Haoran Chen , Zhenwu Zhang , Xiujuan Lv , Jineng Lv , Xiu-Feng Huang , Junzhao Zhao , Chao-Po Lin , Caixia Gao , Jinwei Zhang , Feng Gu

Journal: Mol Ther

PubMed ID: 35821638

Doi: 10.1016/j.ymthe.2022.07.010

Products & Services: Gene Synthesis

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