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Relative role of border restrictions, case finding and contact tracing in controlling SARS-CoV-2 in the presence of undetected transmission: a mathematical modelling study

Authors: Rachael Pung, Hannah E Clapham, Timothy W Russell, Vernon J Lee, Adam J Kucharski

Journal: BMC Med

PubMed ID: 36927576

Doi: 10.1186/s12916-023-02802-0

Products & Services: Protein and Antibody Isolation

Arc ubiquitination regulates endoplasmic reticulum-mediated Ca release and CaMKII signaling

Authors: Mohammad A Ghane, Wei Wei, Dina W Yakout, Zachary D Allen, Cassandra L Miller, Bin Dong, Jenny J Yang, Ning Fang, Angela M Mabb

Journal: Front Cell Neurosci

PubMed ID: 36998269

Doi: 10.3389/fncel.2023.1091324

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JNK Activation in Alzheimer's Disease Is Driven by Amyloid β and Is Associated with Tau Pathology

Authors: Maite Solas, Silvia Vela, Cristian Smerdou, Eva Martisova, Iván Martínez-Valbuena, María-Rosario Luquin, María J Ramírez

Journal: ACS Chem Neurosci

PubMed ID: 36976903

Doi: 10.1021/acschemneuro.3c00093

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Anti-human immunodeficiency virus-1 activity of MoMo30 protein isolated from the traditional African medicinal plant Momordica balsamina

Authors: Mahfuz Khan, Amad Diop, Erick Gbodossou, Peng Xiao, Morgan Coleman, Kenya De Barros, Hao Duong, Vincent C Bond, Virginia Floyd, Kofi Kondwani, Valerie Montgomery Rice, Sandra Harris-Hooker, Francois Villinger, Michael D Powell

Journal: Virol J

PubMed ID: 36949470

Doi: 10.1186/s12985-023-02010-5

Products & Services: Molecular Biology Reagents

Identification of tagged glycans with a protein nanopore

Authors: Minmin Li, Yuting Xiong, Yuchen Cao, Chen Zhang, Yuting Li, Hanwen Ning, Fan Liu, Han Zhou, Xiaonong Li, Xianlong Ye, Yue Pang, Jiaming Zhang, Xinmiao Liang, Guangyan Qing

Journal: Nat Commun

PubMed ID: 36977665

Doi: 10.1038/s41467-023-37348-5

Products & Services: Codon Optimization

Programmable protein delivery with a bacterial contractile injection system

Authors: Joseph Kreitz, Mirco J Friedrich, Akash Guru, Blake Lash, Makoto Saito, Rhiannon K Macrae, Feng Zhang

Journal: Nature

PubMed ID: 36991127

Doi: 10.1038/s41586-023-05870-7

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Conservation and divergence of flg22, pep1 and nlp20 in activation of immune response and inhibition of root development

Authors: Yan Huang, Junmei Cui, Meng Li, Rongqian Yang, Yang Hu, Xiaosong Yu, Ying Chen, Qiqi Wu, Huipeng Yao, Guozhi Yu, Jinya Guo, Huaiyu Zhang, Shuang Wu, Yi Cai

Journal: Plant Sci

PubMed ID: 36963637

Doi: 10.1016/j.plantsci.2023.111686

Products & Services: Peptide Synthesis

The TINCR ubiquitin-like microprotein is a tumor suppressor in squamous cell carcinoma

Authors: Lucia Morgado-Palacin, Jessie A Brown, Thomas F Martinez, Juana M Garcia-Pedrero, Farhad Forouhar, S Aidan Quinn, Clara Reglero, Joan Vaughan, Yasamin Hajy Heydary, Cynthia Donaldson, Sandra Rodriguez-Perales, Eva Allonca, Rocio Granda-Diaz, Agustin F Fernandez, Mario F Fraga, Arianna L Kim, Jorge Santos-Juanes, David M Owens, Juan P Rodrigo, Alan Saghatelian, Adolfo A Ferrando

Journal: Nat Commun

PubMed ID: 36899004

Doi: 10.1038/s41467-023-36713-8

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Structural basis of peptide recognition and activation of endothelin receptors

Authors: Yujie Ji, Jia Duan, Qingning Yuan, Xinheng He, Gong Yang, Shengnan Zhu, Kai Wu, Wen Hu, Tianyu Gao, Xi Cheng, Hualiang Jiang, H Eric Xu, Yi Jiang

Journal: Nat Commun

PubMed ID: 36882417

Doi: 10.1038/s41467-023-36998-9

Products & Services: Custom DNA/RNA Oligos

Cytokinin-responsive MdTCP17 interacts with MdWOX11 to repress adventitious root primordium formation in apple rootstocks

Authors: Jiangping Mao, Chundong Niu, Ke Li, Li Fan, Zhimin Liu, Shaohuan Li, Doudou Ma, Muhammad Mobeen Tahir, Libo Xing, Caiping Zhao, Juanjuan Ma, Na An, Mingyu Han, Xiaolin Ren, Dong Zhang

Journal: Plant Cell

PubMed ID: 36544357

Doi: 10.1093/plcell/koac369

Products & Services: Monoclonal Antibody Services

Cryopreservation modifies the distribution of the prostate-derived lectin SL15 on the llama (Lama glama) sperm

Authors: Renato Zampini, Ximena A Castro-González, Micaela Scandura, Luciana M Sari, Ana V Diaz, Alfredo Martin, Martin E Argañaraz, Silvana A Apichela

Journal: Theriogenology

PubMed ID: 36933286

Doi: 10.1016/j.theriogenology.2023.03.006

Products & Services: Molecular Biology Reagents

Targeted DNA integration in human cells without double-strand breaks using CRISPR RNA-guided transposases

Authors: George D Lampe, Rebeca T King, Tyler S Halpin-Healy, Sanne E Klompe, Marcus I Hogan, Phuc Leo H Vo, Stephen Tang, Alejandro Chavez, Samuel H Sternberg

Journal: biorxiv

PubMed ID: 36993517

Doi: 10.1101/2023.03.17.533036

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KRT5 mutation regulate melanin metabolism through notch signalling pathway between keratinocytes and melanocytes

Authors: Weixue Jia, Yuanyuan Zhang, Xue Wang, Lingling Luo, Heng Sun, Yiqun Jiang, Jianbo Wang, Qiuxia Mao, Youming Guo, Lingzhuo Kong, Ran Mo, Chengrang Li

Journal: Exp Dermatol

PubMed ID: 36809573

Doi: 10.1111/exd.14761

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Immunoglobulin G subclasses confer protection against bloodstream dissemination through distinct mechanisms in mouse models

Authors: Xinhai Chen, Haley Gula, Tonu Pius, Chong Ou, Margaryta Gomozkova, Lai-Xi Wang, Olaf Schneewind, Dominique Missiakas

Journal: Proc Natl Acad Sci U S A

PubMed ID: 36972444

Doi: 10.1073/pnas.2220765120

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High-force catch bonds between the Staphylococcus aureus surface protein SdrE and complement regulator factor H drive immune evasion

Authors: Telmo O Paiva, Joan A Geoghegan, Yves F Dufrêne

Journal: Commun Biol

PubMed ID: 36944849

Doi: 10.1038/s42003-023-04660-1

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Nanotopographic micro-nano forces finely tune the conformation of macrophage mechanosensitive membrane protein integrin β to manipulate inflammatory responses

Authors: Yuanlong Guo, Yong Ao, Chen Ye, Ruidi Xia, Jiaomei Mi, Zhengjie Shan, Mengru Shi, Lv Xie, Zetao Chen

Journal: Nano Res

PubMed ID: 37359074

Doi: 10.1007/s12274-023-5550-0

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Colorectal cancer-derived extracellular vesicles containing HSP70 enhance macrophage phagocytosis by up-regulating MARCO expression

Authors: Yu Sun, Wenjun Xiao, Yang Yu, Yuchen Jiang, Zhijie Xiao, Defa Huang, Tianyu Zhong, Jiang Li, Xi Xiang, Yulong He, Zhigang Li

Journal: Exp Cell Res

PubMed ID: 36958650

Doi: 10.1016/j.yexcr.2023.113565

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Development of an efficient method for selection of stable cell pools for protein expression and surface display with Expi293F cells

Authors: Chuan Chen, Zening Wang, Zehua Sun, Wei Li, Dimiter S Dimitrov

Journal: Cell Biochem Funct

PubMed ID: 36864545

Doi: 10.1002/cbf.3787

Products & Services: Recombinant Proteins

Uman-type neurofilament light antibodies are effective reagents for the imaging of neurodegeneration

Authors: Gerry Shaw, Irina Madorsky, Ying Li, YongSheng Wang, Marda Jorgensen, Sabhya Rana, David D Fuller

Journal: Brain Commun

PubMed ID: 37091583

Doi: 10.1093/braincomms/fcad067

Products & Services: Protein and Antibody Isolation

Silmitasertib (CX-4945), a Clinically Used CK2-Kinase Inhibitor with Additional Effects on GSK3β and DYRK1A Kinases: A Structural Perspective

Authors: Przemyslaw Grygier, Katarzyna Pustelny, Jakub Nowak, Przemyslaw Golik, Grzegorz M Popowicz, Oliver Plettenburg, Grzegorz Dubin, Filipe Menezes, Anna Czarna

Journal: J Med Chem

PubMed ID: 36883902

Doi: 10.1021/acs.jmedchem.2c01887

Products & Services: Combinatorial Mutant library

JMJD1C promotes smooth muscle cell proliferation by activating glycolysis in pulmonary arterial hypertension

Authors: Chen Zhang, Yue Sun, Yingying Guo, Jingjing Xu, Haiyan Zhao

Journal: Cell Death Discov

PubMed ID: 36934091

Doi: 10.1038/s41420-023-01390-5

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Nuclease activity of Plasmodium falciparum Alba family protein PfAlba3

Authors: Chinmoy Banerjee, Shiladitya Nag, Manish Goyal, Debanjan Saha, Asim Azhar Siddiqui, Somnath Mazumder, Subhashis Debsharma, Saikat Pramanik, Uday Bandyopadhyay

Journal: Cell Rep

PubMed ID: 36947546

Doi: 10.1016/j.celrep.2023.112292

Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders

Authors: Elżbieta Wątor , Piotr Wilk , Artur Biela, Michał Rawski , Krzysztof M Zak, Wieland Steinchen , Gert Bange, Sebastian Glatt , Przemysław Grudnik

Journal: Nature Communications

PubMed ID: 36973244

Doi: 10.1038/s41467-023-37305-2

Products & Services: Gene Synthesis Gene Synthesis Gene Synthesis

Design and preclinical evaluation of a universal SARS-CoV-2 mRNA vaccine

Authors: Jane Qin, Ju Hyeong Jeon, Jiangsheng Xu, Laura Katherine Langston, Ramesh Marasini, Stephanie Mou, Brian Montoya, Carolina R Melo-Silva, Hyo Jin Jeon, Tianyi Zhu, Luis J Sigal, Renhuan Xu, Huabin Zhu

Journal: Front Immunol

PubMed ID: 37033973

Doi: 10.3389/fimmu.2023.1126392

Products & Services: Peptide Synthesis

Novel multi-epitope vaccine against bovine brucellosis: approach from immunoinformatics to expression

Authors: Somayyeh Rahimnahal, Shahnaz Yousefizadeh, Yahya Mohammadi

Journal: J Biomol Struct Dyn

PubMed ID: 36927475

Doi: 10.1080/07391102.2023.2188962

Products & Services: Protein and Antibody Isolation

Entropy-driven assisted T7 RNA polymerase amplification-activated CRISPR/Cas13a activity for SARS-CoV-2 detection in human pharyngeal swabs and environment by an electrochemiluminescence biosensor

Authors: Jihua Wei, Zichun Song, Jiuying Cui, Yuanxun Gong, Qianli Tang, Kai Zhang, Xinlei Song, Xianjiu Liao

Journal: J Hazard Mater

PubMed ID: 36965355

Doi: 10.1016/j.jhazmat.2023.131268

Products & Services: Protein and Antibody Isolation

Exploring the structural basis to develop efficient multi-epitope vaccines displaying interaction with HLA and TAP and TLR3 molecules to prevent NIPAH infection, a global threat to human health

Authors: Sukrit Srivastava, Sonia Verma, Mohit Kamthania, Ajay Kumar Saxena, Kailash C Pandey, Veena Pande, Michael Kolbe

Journal: PLoS ONE

PubMed ID: 36920996

Doi: 10.1371/journal.pone.0282580

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Mapping the conformational landscape of the stimulatory heterotrimeric G protein

Authors: Shuya Kate Huang, Louis-Philippe Picard, Rima S M Rahmatullah, Aditya Pandey, Ned Van Eps, Roger K Sunahara, Oliver P Ernst, Adnan Sljoka, R Scott Prosser

Journal: Nat Struct Mol Biol

PubMed ID: 36997760

Doi: 10.1038/s41594-023-00957-1

Products & Services: Molecular Biology Reagents

Vimentin Is an Attachment Receptor for Mycoplasma pneumoniae P1 Protein

Authors: Kailan Peng, Yating Liao, Xia Li, Dongdong Zeng, Youyuan Ye, Li Chen, Zhuo Zeng, Yanhua Zeng

Journal: Microbiol Spectr

PubMed ID: 36912679

Doi: 10.1128/spectrum.04489-22

Products & Services: Molecular Biology Reagents

Human immunoglobulin gene allelic variation impacts germline-targeting vaccine priming

Authors: Allan C deCamp, Martin M Corcoran, William J Fulp, Jordan R Willis, Christopher A Cottrell, Daniel L V Bader, Oleksandr Kalyuzhniy, David J Leggat, Kristen W Cohen, Ollivier Hyrien, Sergey Menis, Greg Finak, Lamar Ballweber-Fleming, Abhinaya Srikanth, Jason R Plyler, Farhad Rahaman, Angela Lombardo, Vincent Philiponis, Rachael E Whaley, Aaron Seese, Joshua Brand, Alexis M Ruppel, Wesley Hoyland, Celia R Mahoney, Alberto Cagigi, Alison Taylor, David M Brown, David R Ambrozak, Troy Sincomb, Tina-Marie Mullen, Janine Maenza, Orpheus Kolokythas, Nadia Khati, Jeffrey Bethony, Mario Roederer, David Diemert, Richard A Koup, Dagna S Laufer, Juliana M McElrath, Adrian B McDermott, Gunilla B Karlsson Hedestam, William R Schief

Journal: medrxiv

PubMed ID: 36993183

Doi: 10.1101/2023.03.10.23287126

Products & Services: Molecular Biology Reagents

Structure-activity relationship of GPR15L peptide analogues and investigation of their interaction with the GPR15 receptor

Authors: Yufang Deng, Claudia V Perez Almeria, Lieke van Gijzel, Kay Schaller, Line Vedel, David E Gloriam, Trond Ulven, Hans Bräuner-Osborne

Journal: Basic Clin Pharmacol Toxicol

PubMed ID: 36930875

Doi: 10.1111/bcpt.13861

Products & Services: Molecular Biology Reagents

Plasticity in airway smooth muscle differentiation during mouse lung development

Authors: Katharine Goodwin, Bezia Lemma, Pengfei Zhang, Adam Boukind, Celeste M Nelson

Journal: Dev Cell

PubMed ID: 36868232

Doi: 10.1016/j.devcel.2023.02.002

Products & Services: Protein and Antibody Isolation

Alphaherpesvirus upregulates NDRG1 expression to facilitate the nuclear import of viral UL31 and UL34 proteins

Authors: Shuang Zhang, Sheng-Li Ming, Lei Zeng, Lu-Fang Wang, Chao Zhang, He-Shui Zhu, Guo-Yu Yang, Gai-Ping Zhang, Bei-Bei Chu, Jiang Wang

Journal: J Med Virol

PubMed ID: 36807585

Doi: 10.1002/jmv.28591

Products & Services: Protein and Antibody Isolation

Structural basis for motilin and erythromycin recognition by motilin receptor

Authors: Chongzhao You, Yumu Zhang, Youwei Xu, Peiyu Xu, Zhen Li, Huadong Li, Sijie Huang, Zecai Chen, Jingru Li, H Eric Xu, Yi Jiang

Journal: SCIENCE ADVANCES

PubMed ID: 36921049

Doi: 10.1126/sciadv.ade9020

Products & Services: Peptide Synthesis

Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity

Authors: Tong Han, Xujun Wang, Sailing Shi, Wubing Zhang, Jue Wang, Qiu Wu, Ziyi Li, Jingxin Fu, Rongbin Zheng, Jiamin Zhang, Qin Tang, Peng Zhang, Chenfei Wang

Journal: Cancer immunology research

PubMed ID: 36629846

Doi: 10.1158/2326-6066.CIR-22-0056

Products & Services: Protein Electrophoresis and Western Protein Electrophoresis and Western

Urease of Aspergillus fumigatus Is Required for Survival in Macrophages and Virulence

Authors: Zhenzhen Xiong, Nan Zhang, Liru Xu, Zhiduo Deng, Jarukitt Limwachiranon, Yaojie Guo, Yi Han, Wei Yang, Daniel H Scharf

Journal: Microbiol Spectr

PubMed ID: 36916906

Doi: 10.1128/spectrum.03508-22

Products & Services: Protein and Antibody Isolation

Targeted DNA integration in human cells without double-strand breaks using CRISPR-associated transposases

Authors: George D Lampe, Rebeca T King, Tyler S Halpin-Healy, Sanne E Klompe, Marcus I Hogan, Phuc Leo H Vo, Stephen Tang, Alejandro Chavez, Samuel H Sternberg

Journal: Nat Biotechnol

PubMed ID: 36991112

Doi: 10.1038/s41587-023-01748-1

Products & Services: Gene Synthesis

Fine-tuning Bacterial Cyclic di-AMP Production for Durable Antitumor Effects Through the Activation of the STING Pathway

Authors: Yu Jiang, Xiyuan Li, Fenghui Qian, Bingbing Sun, Xiyuan Wang, Yan Zhang, Deqiang Zhang, Meiyu Geng, Zuoquan Xie, Sheng Yang

Journal: Research (Wash D C)

PubMed ID: 37011280

Doi: 10.34133/research.0102

Products & Services: Gene Synthesis

Antitumor effect of neoantigen-reactive T cells combined with PD1 inhibitor therapy in mouse lung cancer

Authors: Huan Qin, Haiyan Hu, Ximing Liao, Pei Zhao, Wenjuan He, Xiaoping Su, Jiaxing Sun, Qiang Li

Journal: J Cancer Res Clin Oncol

PubMed ID: 36933035

Doi: 10.1007/s00432-023-04683-5

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Authors: Sarah Temmam, Xavier Montagutelli, Cécile Herate, Flora Donati, Béatrice Regnault, Mikael Attia, Eduard Baquero Salazar, Delphine Chretien, Laurine Conquet, Grégory Jouvion, Juliana Pipoli Da Fonseca, Thomas Cokelaer, Faustine Amara, Francis Relouzat, Thibaut Naninck, Julien Lemaitre, Nathalie Derreudre-Bosquet, Quentin Pascal, Massimiliano Bonomi, Thomas Bigot, Sandie Munier, Felix A Rey, Roger Le Grand, Sylvie van der Werf, Marc Eloit

Journal: EMBO Rep

PubMed ID: 36876574

Doi: 10.15252/embr.202256055

Products & Services: Recombinant Proteins

A short-chain carbonyl reductase mutant is an efficient catalyst in the production of (R)-1,3-butanediol

Authors: Xiaoyan Guo, Yunfang Gao, Fangzheng Liu, Yong Tao, Haibo Jin, Jianjun Wang, Sheng Wu

Journal: Microb Biotechnol

PubMed ID: 36946330

Doi: 10.1111/1751-7915.14249

Products & Services: Molecular Biology Reagents

Impact of homologous and heterologous boosters in neutralizing antibodies titers against SARS-CoV-2 Omicron in solid-organ transplant recipients

Authors: Aracelly Gaete-Argel, Vicente Saavedra-Alarcón, Denis Sauré, Luis Alonso-Palomares, Mónica L Acevedo, Marion Alarcón, Susan M Bueno, Alexis M Kalergis, Ricardo Soto-Rifo, Fernando Valiente-Echeverría, Claudia P Cortes

Journal: Front Immunol

PubMed ID: 36999018

Doi: 10.3389/fimmu.2023.1135478

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Production of neutralizing antibody fragment variants in the cytoplasm of E coli for rapid screening: SARS-CoV-2 a case study

Authors: Aatir A Tungekar, Rosario Recacha, Lloyd W Ruddock

Journal: Sci Rep

PubMed ID: 36927743

Doi: 10.1038/s41598-023-31369-2

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Adenosine deaminase augments SARS-CoV-2 specific cellular and humoral responses in aged mouse models of immunization and challenge

Authors: Ebony N Gary, Nicholas J Tursi, Bryce M Warner, Gina Cuismano, Jennifer Connors, Elizabeth M Parzych, Bryan D Griffin, Matthew R Bell, Ali R Ali, Drew Frase, Casey E Hojecki, Gabriela A Canziani, Irwin Chaiken, Toshitha Kannan, Estella Moffat, Carissa Embury-Hyatt, Sarah K Wooton, Andrew Kossenkov, Ami Patel, Darwyn Kobasa, Michele A Kutzler, Elias K Haddad, David B Weiner

Journal: Front Immunol

PubMed ID: 36999023

Doi: 10.3389/fimmu.2023.1138609

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Identification of specific and shared epitopes at the extreme N-terminal VP1 of Coxsackievirus A4, A2 and A5 by monoclonal antibodies

Authors: Yu-Xuan Tian, Wei-Ping Jin, Zhen-Ni Wei, Shi-Yun Lv, Meng-Jun Wang, Sheng-Li Meng, Jing Guo, Ze-Jun Wang, Shuo Shen

Journal: Virus Res

PubMed ID: 36805409

Doi: 10.1016/j.virusres.2023.199074

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PF-D-Trimer, a protective SARS-CoV-2 subunit vaccine: immunogenicity and application

Authors: Zhihao Zhang, Jinhu Zhou, Peng Ni, Bing Hu, Normand Jolicoeur, Shuang Deng, Qian Xiao, Qian He, Gai Li, Yan Xia, Mei Liu, Cong Wang, Zhizheng Fang, Nan Xia, Zhe-Rui Zhang, Bo Zhang, Kun Cai, Yan Xu, Binlei Liu

Journal: npj Vaccines

PubMed ID: 36922524

Doi: 10.1038/s41541-023-00636-8

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Active Site Aromatic Residues Play a Dual Role in the Substrate Interaction and Protein Structure in Functional Dimers of CYP121A1 of

Authors: Christopher S Campomizzi, Amit Kumar, Patil Pranita Uttamrao, Jack J Stallone, George E Ghanatios, Thenmalarchelvi Rathinavelan, D Fernando Estrada

Journal: ACS Infect Dis

PubMed ID: 36976833

Doi: 10.1021/acsinfecdis.2c00531

Products & Services: Protein and Antibody Isolation

A chemically controlled Cas9 switch enables temporal modulation of diverse effectors

Authors: Cindy T Wei, Nicholas A Popp, Omri Peleg, Rachel L Powell, Elhanan Borenstein, Dustin J Maly, Douglas M Fowler

Journal: Nat Chem Biol

PubMed ID: 36879061

Doi: 10.1038/s41589-023-01278-6

Products & Services: Codon Optimization

High Autophagy Patterns in Swelling Platelets During Apheresis Platelet Storage

Authors: Lu Yu, Shifang Yu, Yunlei He, Gang Deng, Qiang Li