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A short-chain carbonyl reductase mutant is an efficient catalyst in the production of (R)-1,3-butanediol

Authors: Xiaoyan Guo, Yunfang Gao, Fangzheng Liu, Yong Tao, Haibo Jin, Jianjun Wang, Sheng Wu

Journal: Microb Biotechnol

PubMed ID: 36946330

Doi: 10.1111/1751-7915.14249

Products & Services: Molecular Biology Reagents

Impact of homologous and heterologous boosters in neutralizing antibodies titers against SARS-CoV-2 Omicron in solid-organ transplant recipients

Authors: Aracelly Gaete-Argel, Vicente Saavedra-Alarcón, Denis Sauré, Luis Alonso-Palomares, Mónica L Acevedo, Marion Alarcón, Susan M Bueno, Alexis M Kalergis, Ricardo Soto-Rifo, Fernando Valiente-Echeverría, Claudia P Cortes

Journal: Front Immunol

PubMed ID: 36999018

Doi: 10.3389/fimmu.2023.1135478

Products & Services: Molecular Biology Reagents

Production of neutralizing antibody fragment variants in the cytoplasm of E coli for rapid screening: SARS-CoV-2 a case study

Authors: Aatir A Tungekar, Rosario Recacha, Lloyd W Ruddock

Journal: Sci Rep

PubMed ID: 36927743

Doi: 10.1038/s41598-023-31369-2

Products & Services: Molecular Biology Reagents

Myosin-X recruits lamellipodin to filopodia tips

Authors: Ana Popović, Mitro Miihkinen, Sujan Ghimire, Rafael Saup, Max L B Grönloh, Neil J Ball, Benjamin T Goult, Johanna Ivaska, Guillaume Jacquemet

Journal: J Cell Sci

PubMed ID: 36861887

Doi: 10.1242/jcs.260574

Products & Services: Gene Synthesis

Cryo-EM structure of human eIF5A-DHS complex reveals the molecular basis of hypusination-associated neurodegenerative disorders

Authors: Elżbieta Wątor , Piotr Wilk , Artur Biela, Michał Rawski , Krzysztof M Zak, Wieland Steinchen , Gert Bange, Sebastian Glatt , Przemysław Grudnik

Journal: Nature Communications

PubMed ID: 36973244

Doi: 10.1038/s41467-023-37305-2

Products & Services: Gene Synthesis Gene Synthesis Gene Synthesis

Genome-wide identification and characterization of tomato 14–3-3 (SlTFT) genes and functional analysis of SlTFT6 under heat stress

Authors: Yunfei Liang, Fang Ma, Ruili Zhang, Wenyu Li, Jiao Dang, Huai Su, Boyu Li, Tixu Hu, Mingke Zhang, Yan Liang, Xiangqiang Zhan

Journal: Physiologia plantarum

PubMed ID: 36906839

Doi: 10.1111/ppl.13888

Products & Services: Transient Expression(INACTIVE)

Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel

Authors: Mingfeng Zhang, Yuanyue Shan, Duanqing Pei

Journal: nature COMMUNICATION

PubMed ID: 36928654

Doi: 10.1038/s41467-023-37204-6

Products & Services: Nucleic Acid Purification

A swapped genetic code prevents viral infections and gene transfer

Authors: Akos Nyerges, Svenja Vinke, Regan Flynn, Siân V Owen, Eleanor A Rand, Bogdan Budnik, Eric Keen, Kamesh Narasimhan, Jorge A Marchand, Maximilien Baas-Thomas, Min Liu, Kangming Chen, Anush Chiappino-Pepe, Fangxiang Hu, Michael Baym, George M Church

Journal: Nature

PubMed ID: 36922599

Doi: 10.1038/s41586-023-05824-z

Products & Services: Gene Synthesis

A riboswitch separated from its ribosome-binding site still regulates translation

Authors: Griffin M Schroeder, Olayinka Akinyemi, Jeffrey Malik, Caroline M Focht, Elizabeth M Pritchett, Cameron D Baker, James P McSally, Jermaine L Jenkins, David H Mathews, Joseph E Wedekind

Journal: Nucleic Acids Research

PubMed ID: 36762498

Doi: 10.1093/nar/gkad056.

Products & Services: Gene Synthesis

Mechanism of sphingolipid homeostasis revealed by structural analysis of Arabidopsis SPT-ORM1 complex

Authors: Peng Liu, Tian Xie, Xinyue Wu, Gongshe Han, Sita D Gupta, Zike Zhang, Jian Yue, Feitong Dong, Kenneth Gable, Somashekarappa Niranjanakumari, Wanyuan Li, Lin Wang, Wenchen Liu, Ruifeng Yao, Edgar B Cahoon, Teresa M Dunn, Xin Gong

Journal: SCIENCE ADVANCES

PubMed ID: 36989369

Doi: 10.1126/sciadv.adg0728

Products & Services: Protein and Antibody Isolation

The Trypanosoma brucei MISP family of invariant proteins is co-expressed with BARP as triple helical bundle structures on the surface of salivary gland forms, but is dispensable for parasite development within the tsetse vector

Authors: Aitor Casas-Sanchez, Raghavendran Ramaswamy, Samïrah Perally, Lee R Haines, Clair Rose, Marcela Aguilera-Flores, Susana Portillo, Margot Verbeelen, Shahid Hussain, Laura Smithson, Cristina Yunta, Michael J Lehane, Sue Vaughan, Jan van den Abbeele, Igor C Almeida, Martin J Boulanger, Álvaro Acosta-Serrano

Journal: PLoS Pathog

PubMed ID: 36996244

Doi: 10.1371/journal.ppat.1011269

Products & Services: Protein and Antibody Isolation

Fabrication of bFGF/polydopamine-loaded PEEK implants for improving soft tissue integration by upregulating Wnt/β-catenin signaling

Authors: Xiaohu Wang, Ning Ma, Li Feng, Mingkui Shen, Yaqi Zhou, Xinan Zhang, Ruichao Huang, Li Zhou, Shanfeng Ji, Yongli Lou, Zhi Zhu

Journal: Heliyon

PubMed ID: 37012909

Doi: 10.1016/j.heliyon.2023.e14800

Products & Services: Protein and Antibody Isolation

Development and Evaluation of Recombinant B-Cell Multi-Epitopes of PDHA1 and GAPDH as Subunit Vaccines against Infection in Flounder ()

Authors: Xiuzhen Sheng, Honghua Zhang, Min Liu, Xiaoqian Tang, Jing Xing, Heng Chi, Wenbin Zhan

Journal: Vaccines (Basel)

PubMed ID: 36992208

Doi: 10.3390/vaccines11030624

Products & Services: Peptide Synthesis

Purification and biochemical characterization of a novel chitosanase cloned from the gene of Kitasatospora setae KM-6054 and its application in the production of chitooligosaccharides

Authors: Yinxiao Xu, Hui Wang, Benwei Zhu, Zhong Yao, Ling Jiang

Journal: World J Microbiol Biotechnol

PubMed ID: 36905451

Doi: 10.1007/s11274-023-03561-z

Products & Services: Protein and Antibody Isolation

Mucus-penetrating nonviral gene vaccine processed in the epithelium for inducing advanced vaginal mucosal immune responses

Authors: Qunjie Bi, Xu Song, Yangyang Zhao, Xueyi Hu, Huan Yang, Rongrong Jin, Yu Nie

Journal: Acta Pharmacuetica Sinica.B

PubMed ID: 36970203

Doi: 10.1016/j.apsb.2022.11.004

Products & Services: Peptide Synthesis

New insights underlying the early events of dopaminergic dysfunction in Parkinson’s Disease

Authors: Hannah L. Dela Cruz, Esther L. Dela Cruz, Cody J. Zurhellen, Herbert T. York, Jim A. Baun, Joshua L. Dela Cruz, Jay S. Dela Cruz

Journal: biorxiv

Doi: 10.1101/2020.09.27.313957

Products & Services: Endotoxin Detection & Removal System

Epinecidin-1, a marine antifungal peptide, inhibits Botrytis cinerea and delays gray mold in postharvest peaches

Authors: Li Fan , Yingying Wei , Yi Chen , Shu Jiang , Feng Xu , Chundan Zhang , Hongfei Wang , Xingfeng Shao

Journal: Food Chem .

PubMed ID: 36191421

Doi: 10.1016/j.foodchem.2022.134419

Products & Services: Peptide Synthesis

Infection with wild-type SARS-CoV-2 elicits broadly neutralizing and protective antibodies against omicron subvariants

Authors: Bin Ju, Qi Zhang, Ziyi Wang, Zhen Qin Aw, Peng Chen, Bing Zhou, Ruoke Wang, Xiangyang Ge, Qining Lv, Lin Cheng, Rui Zhang, Yi Hao Wong, Huixin Chen, Haiyan Wang, Sisi Shan, Xuejiao Liao, Xuanling Shi, Lei Liu, Justin Jang Hann Chu, Xinquan Wang, Zheng Zhang, Linqi Zhang

Journal: Nat Immunol

PubMed ID: 36914890

Doi: 10.1038/s41590-023-01449-6

Products & Services: DNA Sequencing

Genetically engineered CXCR4-modified exosomes for delivery of miR-126 mimics to macrophages alleviate periodontitis

Authors: Haotian Luo, Danying Chen, Ruoyu Li, Runze Li, Yungshan Teng, Yang Cao, Xuenong Zou, Weicai Wang, Chen Zhou

Journal: J Nanobiotechnology

PubMed ID: 36991451

Doi: 10.1186/s12951-023-01863-w

Products & Services: ELISA Kits

The Influence of Protein Charge and Molecular Weight on the Affinity of Aptamers

Authors: Alissa Drees, Tung Lam Trinh, Markus Fischer

Journal: Pharmaceuticals (Basel)

PubMed ID: 36986556

Doi: 10.3390/ph16030457

Products & Services: Custom DNA/RNA Oligos

Identification of Three Human POLH Germline Variants Defective in Complementing the UV- and Cisplatin-Sensitivity of POLH-Deficient Cells

Authors: Mina Yeom, Jin-Kyung Hong, Joo-Ho Shin, Yunjong Lee, Frederick Peter Guengerich, Jeong-Yun Choi

Journal: Int J Mol Sci

PubMed ID: 36982269

Doi: 10.3390/ijms24065198

Products & Services: Custom DNA/RNA Oligos

Dissection of Antibody Responses of Gam-COVID-Vac-Vaccinated Subjects Suggests Involvement of Epitopes Outside RBD in SARS-CoV-2 Neutralization

Authors: Maria Byazrova, Pia Gattinger, Ekaterina Astakhova, Gerhard Hofer, Musa Khaitov, Alexander Filatov, Rudolf Valenta

Journal: Int J Mol Sci

PubMed ID: 36982183

Doi: 10.3390/ijms24065104

Products & Services: Recombinant Antibody Expression

Virus-like Magnetic Mesoporous Silica Particles as a Universal Vaccination Platform against Pathogenic Infections

Authors: Mingyang Liu, Yan Zhao, Zhishang Shi, Jeffrey I Zink, Qilin Yu

Journal: ACS Nano

PubMed ID: 36961475

Doi: 10.1021/acsnano.3c00644

Products & Services: Gene Synthesis

DELLA functions evolved by rewiring of associated transcriptional networks

Authors: Asier Briones-Moreno, Jorge Hernández-García, Carlos Vargas-Chávez, Noel Blanco-Touriñán, Alexandros Phokas, Cristina Úrbez, Pablo D Cerdán, Juliet C Coates, David Alabadí, Miguel A Blázquez

Journal: Nat Plants

PubMed ID: 36914897

Doi: 10.1038/s41477-023-01372-6

Products & Services: Gene Synthesis

Identification of HPV16 E1 and E2-specific T cells in the oropharyngeal cancer tumor microenvironment

Authors: Christine McInnis, Shilpa Bhatia, Brinda Vijaykumar, Qiaomu Tian, Yanbo Sun, Del Leistritz-Edwards, Charles T Quinn, Ravi Uppaluri, Ann Marie Egloff, Lakshmi Srinivasan, Daniel C Pregibon, Anthony J Coyle, Glenn J Hanna

Journal: J Immunother Cancer

PubMed ID: 36990508

Doi: 10.1136/jitc-2023-006721

Products & Services: Peptide Synthesis

Interaction of SARS-CoV-2 Nucleocapsid Protein and Human RNA Helicases DDX1 and DDX3X Modulates Their Activities on Double-Stranded RNA

Authors: Camilla Lodola, Massimiliano Secchi, Virginia Sinigiani, Antonella De Palma, Rossana Rossi, Davide Perico, Pier Luigi Mauri, Giovanni Maga

Journal: Int J Mol Sci

PubMed ID: 36982856

Doi: 10.3390/ijms24065784

Products & Services: Plasmid DNA Preparation

To Explore the Binding Affinity of Human γ-Secretase Activating Protein (GSAP) Isoform 4 with APP-C99 Peptides

Authors: Deekshi Angira, Sonali Chaudhary, Arumugam Abiramasundari, Vijay Thiruvenkatam

Journal: ACS Omega

PubMed ID: 37065030

Doi: 10.1021/acsomega.3c01117

Products & Services: Protein and Antibody Isolation

Regenerative marine waste towards CaCO nanoformulation for Alzheimer's therapy

Authors: Prakashkumar Nallasamy, Beema Shafreen Rajamohamed, Jeyakanthan Jeyaraman, Brindhadevi Kathirvel, Suganthy Natarajan

Journal: Environ Res

PubMed ID: 36889568

Doi: 10.1016/j.envres.2023.115631

Products & Services: Peptide Synthesis

Highly Sensitive and Selective Detection of Inorganic Phosphates in the Water Environment by Biosensors Based on Bioluminescence Resonance Energy Transfer

Authors: Jie Yu, Yan Zhang, Yanping Zhao, Xuxiang Zhang, Hongqiang Ren

Journal: Anal Chem

PubMed ID: 36942460

Doi: 10.1021/acs.analchem.2c04748

Products & Services: Protein Electrophoresis and Western

Enhanced Endosomal Signaling and Desensitization of GLP-1R vs GIPR in Pancreatic Beta Cells

Authors: Yusman Manchanda, Stavroula Bitsi, Shiqian Chen, Johannes Broichhagen, Jorge Bernardino de la Serna, Ben Jones, Alejandra Tomas

Journal: Endocrinology

PubMed ID: 36774542

Doi: 10.1210/endocr/bqad028

Products & Services: Molecular Biology Reagents

Identification of Filamin A Mechanobinding Partner III: SAV1 Specifically Interacts with Filamin A Mechanosensitive Domain 21

Authors: Huaguan Zhang, Zhenfeng Mao, Ziwei Yang, Fumihiko Nakamura

Journal: Biochemistry

PubMed ID: 36857526

Doi: 10.1021/acs.biochem.2c00665

Products & Services: Molecular Biology Reagents

Peptides that Mimic RS repeats modulate phase separation of SRSF1, revealing a reliance on combined stacking and electrostatic interactions

Authors: Talia Fargason, Naiduwadura Ivon Upekala De Silva, Erin King, Zihan Zhang, Trenton Paul, Jamal Shariq, Steve Zaharias, Jun Zhang

Journal: Elife

PubMed ID: 36862748

Doi: 10.7554/eLife.84412

Products & Services: Molecular Biology Reagents

Inflammatory stimulation of astrocytes affects the expression of miRNA-22-3p within NSCs-EVs regulating remyelination by targeting KDM3A

Authors: Tianyu Han, Peiwen Song, Zuomeng Wu, Cancan Wang, Yunlei Liu, Wang Ying, Kaixuan Li, Cailiang Shen

Journal: Stem Cell Res Ther

PubMed ID: 36959678

Doi: 10.1186/s13287-023-03284-w

Products & Services: Molecular Biology Reagents

The force-dependent filamin A-G3BP1 interaction regulates phase-separated stress granule formation

Authors: Ziyi Feng, Zhenfeng Mao, Ziwei Yang, Xiaowei Liu, Fumihiko Nakamura

Journal: J Cell Sci

PubMed ID: 36806943

Doi: 10.1242/jcs.260684

Products & Services: Protein and Antibody Isolation

Engineered production of isoprene from the model green microalga Chlamydomonas reinhardtii

Authors: Razan Z Yahya, Gordon B Wellman, Sebastian Overmans, Kyle J Lauersen

Journal: Metab Eng Commun .

PubMed ID: 37006831

Doi: 10.1016/j.mec.2023.e00221

Products & Services: Gene Synthesis

Efficient hydroxylation of flavonoids by using whole-cell P450 sca-2 biocatalyst in

Authors: Baodong Hu, Xinrui Zhao, Jingwen Zhou, Jianghua Li, Jian Chen, Guocheng Du

Journal: Front Bioeng Biotechnol

PubMed ID: 36873357

Doi: 10.3389/fbioe.2023.1138376

Products & Services: Gene Synthesis

Fused human paraoxonase 1 as a prophylactic agent against organophosphate poisoning

Authors: Prakashkumar Dobariya, Pratik Adhya, Bhupesh Vaidya, Prakash Y Khandave, Shyam Sunder Sharma, Abhay H Pande

Journal: Enzyme Microb Technol

PubMed ID: 36764031

Doi: 10.1016/j.enzmictec.2023.110209

Products & Services: Molecular Biology Reagents

A rapid nucleic acid detection platform based on phosphorothioate-DNA and sulfur binding domain

Authors: Yuting Shuai, Yi Ju, Yuanhang Li, Dini Ma, Lan Jiang, Jingyu Zhang, Gao-Yi Tan, Xueting Liu, Shenlin Wang, Lixin Zhang, Guang Liu

Journal: Synth Syst Biotechnol

PubMed ID: 36875498

Doi: 10.1016/j.synbio.2023.02.002

Products & Services: Protein and Antibody Isolation

Drug repurposing screens identify compounds that inhibit α-synuclein oligomers' membrane disruption and block antibody interactions

Authors: Arun Kumar Somavarapu, Giulia Kleijwegt, Madhu Nagaraj, Parvez Alam, Janni Nielsen, Daniel E Otzen

Journal: Chem Sci

PubMed ID: 36937574

Doi: 10.1039/d2sc05534a

Products & Services: Recombinant Proteins

The molecular mechanism of light-induced bond formation and breakage in the cyanobacteriochrome TePixJ

Authors: Jeannette Ruf, Flavia Bindschedler, David Buhrke

Journal: Phys Chem Chem Phys

PubMed ID: 36752541

Doi: 10.1039/d2cp05856a

Products & Services: Protein and Antibody Isolation

Network of hotspot interactions cluster tau amyloid folds

Authors: Vishruth Mullapudi, Jaime Vaquer-Alicea, Vaibhav Bommareddy, Anthony R Vega, Bryan D Ryder, Charles L White, Marc I Diamond, Lukasz A Joachimiak

Journal: Nat Commun

PubMed ID: 36797278

Doi: 10.1038/s41467-023-36572-3

Products & Services: Peptide Synthesis

Engineered biocontainable RNA virus vectors for non-transgenic genome editing across crop species and genotypes

Authors: Qian Liu, Chenglu Zhao, Kai Sun, Yinlu Deng, Zhenghe Li

Journal: Mol Plant

PubMed ID: 36751129

Doi: 10.1016/j.molp.2023.02.003

Products & Services: Peptide Synthesis

Smartphone-based chemiluminescence detection of aflatoxin B via labelled and label-free dual sensing systems

Authors: Junning Ma, Yue Guan, Fuguo Xing, Yan Wang, Xu Li, Qiang Yu, Xiaohua Yu

Journal: Food Chem

PubMed ID: 36796268

Doi: 10.1016/j.foodchem.2023.135654

Products & Services: Molecular Biology Reagents

Generation and characterization of an immunodeficient mouse model of mucopolysaccharidosis type II

Authors: Miles C Smith, Lalitha R Belur, Andrea D Karlen, Kelly Podetz-Pedersen, Olivia Erlanson, Kanut Laoharawee, Justin Furcich, Troy C Lund, Yun You, Davis Seelig, Beau R Webber, R Scott McIvor

Journal: Mol Genet Metab

PubMed ID: 37023503

Doi: 10.1016/j.ymgme.2023.107539

Products & Services: Gene Synthesis

KLF3 Transcription Activates WNT1 and Promotes the Growth and Metastasis of Gastric Cancer via Activation of the WNT/β-Catenin Signaling Pathway

Authors: Ying Li, Yu Wang, Qinguang Zou, Shouqing Li, Fan Zhang

Journal: Lab Invest

PubMed ID: 36827869

Doi: 10.1016/j.labinv.2023.100078

Products & Services: Protein and Antibody Isolation

Barrier properties of Nup98 FG phases ruled by FG motif identity and inter-FG spacer length

Authors: Sheung Chun Ng, Abin Biswas, Trevor Huyton, Jürgen Schünemann, Simone Reber, Dirk Görlich

Journal: Nat Commun

PubMed ID: 36765044

Doi: 10.1038/s41467-023-36331-4

Products & Services: Protein and Antibody Isolation

Safety and Immunogenicity of Betuvax-CoV-2, an RBD-Fc-Based SARS-CoV-2 Recombinant Vaccine: Preliminary Results of the First-in-Human, Randomized, Double-Blind, Placebo-Controlled Phase I/II Clinical Trial

Authors: Aleksandr V Kudriavtsev, Anna V Vakhrusheva, Nickolay A Kryuchkov, Maria E Frolova, Konstantin A Blagodatskikh, Taras V Ivanishin, Milana Djonovic, Ekaterina A Romanovskaya-Romanko, Anton N Kovalenko, Dmitry A Lioznov, Tatiana G Zubkova, Svetlana V Teplykh, Rodion A Oseshnyuk, Marina A Stukova, Artur A Isaev, Igor V Krasilnikov

Journal: Vaccines (Basel)

PubMed ID: 36851204

Doi: 10.3390/vaccines11020326

Products & Services: Protein and Antibody Isolation

Structure and dynamics of the EGFR/HER2 heterodimer

Authors: Xue Bai, Pengyu Sun, Xinghao Wang, Changkun Long, Shuyun Liao, Song Dang, Shangshang Zhuang, Yongtao Du, Xinyi Zhang, Nan Li, Kangmin He, Zhe Zhang

Journal: Cell Discov

PubMed ID: 36781849

Doi: 10.1038/s41421-023-00523-5

Products & Services: Protein and Antibody Isolation

Design of a stabilized non-glycosylated Pfs48/45 antigen enables a potent malaria transmission-blocking nanoparticle vaccine

Authors: Thayne H Dickey, Richi Gupta, Holly McAleese, Tarik Ouahes, Sachy Orr-Gonzalez, Rui Ma, Olga Muratova, Nichole D Salinas, Jen C C Hume, Lynn E Lambert, Patrick E Duffy, Niraj H Tolia

Journal: npj Vaccines

PubMed ID: 36808125

Doi: 10.1038/s41541-023-00619-9

Products & Services: Protein and Antibody Isolation

Acid-Responsive Immune-Enhancing Chitosan Formulation Capable of Transforming from Particle Stabilization to Polymer Chain Stabilization

Authors: Yongjuan Zou, Xiaoxuan Liu, Qiuting Chen, Hiroyuki Oku, Guanghui Ma, Jie Wu

Journal: ACS Appl Mater Interfaces

PubMed ID: 36825996

Doi: 10.1021/acsami.2c17505

Products & Services: Protein and Antibody Isolation