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Inhibition of the CtBP complex and FBXO11 enhances MHC class II expression and anti-cancer immune responses

Authors: Kah Lok Chan, Juliana Gomez, Chelisa Cardinez, Nishi Kumari, Christina E Sparbier, Enid Y N Lam, Miriam M Yeung, Sylvain Garciaz, James A Kuzich, Doen Ming Ong, Fiona C Brown, Yih-Chih Chan, Dane Vassiliadis, Elanor N Wainwright, Ali Motazedian, Andrea Gillespie, Katie A Fennell, Junyun Lai, Imran G House, Laura Macpherson, Ching-Seng Ang, Sarah-Jane Dawson, Paul A Beavis, Andrew H Wei, Marian L Burr, Mark A Dawson

Journal: Cancer Cell

PubMed ID: 36179686

Doi: 10.1016/j.ccell.2022.09.007

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Involvement of transmembrane protein 184a during angiogenesis in zebrafish embryos

Authors: Cassandra J Field, Alexis M Perez, Taryn Samet, Victoria Ricles, M Kathryn Iovine, Linda J Lowe-Krentz

Journal: Front Physiol

PubMed ID: 36117693

Doi: 10.3389/fphys.2022.845407

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Adipocyte IRE1α promotes PGC1α mRNA decay and restrains adaptive thermogenesis

Authors: Yong Chen, Zhuyin Wu, Shijia Huang, Xiaoxia Wang, Sijia He, Lin Liu, Yurong Hu, Li Chen, Peng Chen, Songzi Liu, Shengqi He, Bo Shan, Ling Zheng, Sheng-Zhong Duan, Zhiyin Song, Lei Jiang, Qiong A Wang, Zhenji Gan, Bao-Liang Song, Jianmiao Liu, Liangyou Rui, Mengle Shao, Yong Liu

Journal: Nat Metab

PubMed ID: 36123394

Doi: 10.1038/s42255-022-00631-8

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High-efficiency recombinant protein purification using mCherry and YFP nanobody affinity matrices

Authors: Anh T Q Cong, Taylor L Witter, Matthew J Schellenberg

Journal: Protein Sci

PubMed ID: 36040252

Doi: 10.1002/pro.4383

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Residues L55 and W69 of Tva Mediate Entry of Subgroup A Avian Leukosis Virus

Authors: Yuntong Chen, Suyan Wang, Xinyi Li, Mengmeng Yu, Peng Liu, Lingzhai Meng, Ru Guo, Xiaoyan Feng, Aijing Liu, Xiaole Qi, Kai Li, Li Gao, Qing Pan, Yanping Zhang, Changjun Liu, Hongyu Cui, Xiaomei Wang, Yulong Gao

Journal: J Virol

PubMed ID: 36069550

Doi: 10.1128/jvi.00678-22

Products & Services: Proteins, Expression, Isolation and Analysis

Multiplex real-time PCR for the detection and differentiation of equid gammaherpesvirus 2 and 5

Authors: Flavia Fürer, Cornel Fraefel, Julia Lechmann

Journal: J Virol Methods

PubMed ID: 36087793

Doi: 10.1016/j.jviromet.2022.114615

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The structure of a polyketide synthase bimodule core

Authors: Yves U Tittes, Dominik A Herbst, Solène F X Martin, Hugo Munoz-Hernandez, Roman P Jakob, Timm Maier

Journal: Sci Adv

PubMed ID: 36129979

Doi: 10.1126/sciadv.abo6918

Products & Services: Proteins, Expression, Isolation and Analysis

A circular RNA derived from GLIS3 accelerates the proliferation of glioblastoma cells through competitively binding with miR-449c-5p to upregulate CAPG and GLIS3

Authors: Qingjiu Zhou, Mahati Shaya, Yalikun Kugeluke, Qiang Fu, Shaoshan Li, Yisireyili Dilimulati

Journal: BMC Neurosci

PubMed ID: 36114444

Doi: 10.1186/s12868-022-00736-6

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Sec18 supports membrane fusion by promoting Sec17 membrane association

Authors: Amy Orr, William Wickner

Journal: Mol Biol Cell

PubMed ID: 36103252

Doi: 10.1091/mbc.E22-07-0274

Products & Services: Proteins, Expression, Isolation and Analysis

Functional characterization of putative ecdysone transporters in lepidopteran pests

Authors: George-Rafael Samantsidis, Melina Fotiadou, Savvas Tzavellas, Sven Geibel, Ralf Nauen, Luc Swevers, Shane Denecke, John Vontas

Journal: Insect Biochem Mol Biol

PubMed ID: 36064128

Doi: 10.1016/j.ibmb.2022.103830

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Generation and characterization of mouse monoclonal antibodies against the VP4 protein of group A human rotaviruses

Authors: Yuanjun Zeng, Feibo Song, Guoxing Luo, Han Yang, Cao Li, Wei Liu, Tingdong Li, Shiyin Zhang, Yingbin Wang, Chenghao Huang, Shengxiang Ge, Jun Zhang, Ningshao Xia

Journal: Antiviral Res

PubMed ID: 36152816

Doi: 10.1016/j.antiviral.2022.105407

Products & Services: Recombinant Antibody Expression

Molecular advances to study the function, evolution and spectral tuning of arthropod visual opsins

Authors: Marjorie A Liénard, Wendy A Valencia-Montoya, Naomi E Pierce

Journal: Philos Trans R Soc Lond B Biol Sci

PubMed ID: 36058235

Doi: 10.1098/rstb.2021.0279

Products & Services: Codon Optimization

Developmental dynamics of RNA translation in the human brain

Authors: Erin E Duffy, Benjamin Finander, GiHun Choi, Ava C Carter, Iva Pritisanac, Aqsa Alam, Victor Luria, Amir Karger, William Phu, Maxwell A Sherman, Elena G Assad, Naomi Pajarillo, Alexandra Khitun, Elizabeth E Crouch, Sanika Ganesh, Jin Chen, Bonnie Berger, Nenad Sestan, Anne O'Donnell-Luria, Eric J Huang, Eric C Griffith, Julie D Forman-Kay, Alan M Moses, Brian T Kalish, Michael E Greenberg

Journal: Nat Neurosci

PubMed ID: 36171426

Doi: 10.1038/s41593-022-01164-9

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Structure of the PAPP-A complex reveals mechanism of substrate recognition

Authors: Russell A Judge, Janani Sridar, Kathryn Tunyasuvunakool, Rinku Jain, John C K Wang, Christna Ouch, Jun Xu, Amirhossein Mafi, Aaron H Nile, Clint Remarcik, Corey L Smith, Crystal Ghosh, Chen Xu, Vincent Stoll, John Jumper, Amoolya H Singh, Dan Eaton, Qi Hao

Journal: Nat Commun

PubMed ID: 36127359

Doi: 10.1038/s41467-022-33175-2

Products & Services: Proteins, Expression, Isolation and Analysis

Sulfanegen stimulates 3-mercaptopyruvate sulfurtransferase activity and ameliorates Alzheimer's disease pathology and oxidative stress in vivo

Authors: Swetha Pavani Rao, Wei Xie, Ye In Christopher Kwon, Nicholas Juckel, Jiashu Xie, Venkateshwara Rao Dronamraju, Robert Vince, Michael K Lee, Swati S More

Journal: Redox Biol

PubMed ID: 36183541

Doi: 10.1016/j.redox.2022.102484

Products & Services: Proteins, Expression, Isolation and Analysis

Rapid Evaluation of Vaccine Booster Effectiveness against SARS-CoV-2 Variants

Authors: Hoi Lok Cheng, Sing Mei Lim, Huan Jia, Ming Wei Chen, Say Yong Ng, Xiaohong Gao, Jyoti Somani, Sharmila Sengupta, Dousabel M Y Tay, Patrina W L Chua, Abirami R, Sharon Y H Ling, Megan E McBee, Barnaby E Young, Hadley D Sikes, Peter R Preiser

Journal: Microbiol Spectr

PubMed ID: 36069616

Doi: 10.1128/spectrum.02257-22

Active immunotherapy against pathogenic Cis pT231-tau suppresses neurodegeneration in traumatic brain injury mouse models

Authors: Masoume Alipour, Majid Tebianian, Nahid Tofigh, Reyhaneh Sadat Taheri, Sayed Alireza Mousavi, Asal Naseri, Amin Ahmadi, Nayla Munawar, Koorosh Shahpasand

Journal: Neuropeptides

PubMed ID: 36087426

Doi: 10.1016/j.npep.2022.102285

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The design of protozoan phosphoribosyltransferase inhibitors containing non-charged phosphate mimic residues

Authors: Sinan Gai, Kajitha Suthagar, Karl J Shaffer, Wanting Jiao, Yacoba V T Minnow, Kayla Glockzin, Sean W Maatouk, Ardala Katzfuss, Thomas D Meek, Vern L Schramm, Peter C Tyler

Journal: Bioorg Med Chem

PubMed ID: 36209571

Doi: 10.1016/j.bmc.2022.117038

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The KdmB-EcoA-RpdA-SntB chromatin complex binds regulatory genes and coordinates fungal development with mycotoxin synthesis

Authors: Betim Karahoda, Lakhansing Pardeshi, Mevlut Ulas, Zhiqiang Dong, Niranjan Shirgaonkar, Shuhui Guo, Fang Wang, Kaeling Tan, Özlem Sarikaya-Bayram, Ingo Bauer, Paul Dowling, Alastair B Fleming, Brandon T Pfannenstiel, Dianiris Luciano-Rosario, Harald Berger, Stefan Graessle, Mohamed M Alhussain, Joseph Strauss, Nancy P Keller, Koon Ho Wong, Özgür Bayram

Journal: Nucleic Acids Res

PubMed ID: 36095118

Doi: 10.1093/nar/gkac744

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A Comparison of Dinoflagellate Thiolation Domain Binding Proteins Using In Vitro and Molecular Methods

Authors: Ernest Williams, Tsvetan Bachvaroff, Allen Place

Journal: Mar Drugs

PubMed ID: 36135770

Doi: 10.3390/md20090581

Products & Services: Proteins, Expression, Isolation and Analysis

White spot syndrome virus directly activates mTORC1 signaling to facilitate its replication via polymeric immunoglobulin receptor-mediated infection in shrimp

Authors: Pan-Pan Hong, Cang Li, Guo-Juan Niu, Xiao-Fan Zhao, Jin-Xing Wang

Journal: PLoS Pathog

PubMed ID: 36067252

Doi: 10.1371/journal.ppat.1010808

Products & Services: Proteins, Expression, Isolation and Analysis

Translation of cytoplasmic UBA1 contributes to VEXAS syndrome pathogenesis

Authors: Marcela A Ferrada, Sinisa Savic, Daniela Ospina Cardona, Jason C Collins, Hugh Alessi, Fernanda Gutierrez-Rodrigues, Dinesh Babu Uthaya Kumar, Lorena Wilson, Wendy Goodspeed, James S Topilow, Julie J Paik, James A Poulter, Tanaz A Kermani, Matthew J Koster, Kenneth J Warrington, Catherine Cargo, Rachel S Tattersall, Christopher J A Duncan, Anna Cantor, Patrycja Hoffmann, Elspeth M Payne, Hanna Bonnekoh, Karoline Krause, Edward W Cowen, Katherine R Calvo, Bhavisha A Patel, Amanda K Ombrello, Daniel L Kastner, Neal S Young, Achim Werner, Peter C Grayson, David B Beck

Journal: Blood

PubMed ID: 35793467

Doi: 10.1182/blood.2022016985

Products & Services: Gene Synthesis

Characterisation of a common hotspot variant in acute intermittent porphyria sheds light on the mechanism of hydroxymethylbilane synthase function

Authors: Marthe S Christie, Mikko Laitaoja, Aasne K Aarsand, Juha P Kallio, Helene J Bustad

Journal: FEBS Open Bio

PubMed ID: 36115019

Doi: 10.1002/2211-5463.13490

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Atomic force microscopy measurements and model of DNA bending caused by binding of AraC protein

Authors: Mary Lowe, Benjamin Glezer, Brendan Toulan, Brian Hess

Journal: J Mol Recognit

PubMed ID: 36112092

Doi: 10.1002/jmr.2993

Products & Services: Proteins, Expression, Isolation and Analysis

PGAM1 Promotes Glycolytic Metabolism and Paclitaxel Resistance via Pyruvic Acid Production in Ovarian Cancer Cells

Authors: Yan Feng, Xu Zhang, Songfa Zhang, Shanshan Xu, Xiaojing Chen, Caiyun Zhou, Yongmei Xi, Xing Xie, Weiguo Lu

Journal: Front Biosci (Landmark Ed)

PubMed ID: 36224008

Doi: 10.31083/j.fbl2709262

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Squid Suckerin-Spider Silk Fusion Protein Hydrogel for Delivery of Mesenchymal Stem Cell Secretome to Chronic Wounds

Authors: Kenrick Koh, Jun Kit Wang, James Xiao Yuan Chen, Shu Hui Hiew, Hong Sheng Cheng, Bartosz Gabryelczyk, Marcus Ivan Gerard Vos, Yun Sheng Yip, Liyan Chen, Radoslaw M Sobota, Damian Kang Keat Chua, Nguan Soon Tan, Chor Yong Tay, Ali Miserez

Journal: Adv Healthc Mater

PubMed ID: 36177679

Doi: 10.1002/adhm.202201900

Products & Services: Proteins, Expression, Isolation and Analysis

DNA hypermethylation of promoter and reduction of hepatic Kiss1r in female rats with type 2 diabetes

Authors: Kamil Ziarniak, Tony Yang, Cayla Boycott, Megan Beetch, Maciej Sassek, Emilia Grzeda, Yuexi Ma, Joanna H Sliwowska, Barbara Stefanska

Journal: Epigenetics

PubMed ID: 36094166

Doi: 10.1080/15592294.2022.2119120

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Immunoregulatory effects of testosterone supplementation combined with exercise training in men with Inclusion Body Myositis: a double-blind, placebo-controlled, cross-over trial

Authors: Jerome D Coudert, Nataliya Slater, Anuradha Sooda, Kelly Beer, Ee Mun Lim, Conchita Boyder, Rui Zhang, Frank L Mastaglia, Yvonne C Learmonth, Timothy J Fairchild, Bu B Yeap, Merrilee Needham

Journal: Clin Transl Immunology

PubMed ID: 36188123

Doi: 10.1002/cti2.1416

Products & Services: Proteins, Expression, Isolation and Analysis

A plant virus hijacks phosphatidylinositol-3,5-bisphosphate to escape autophagic degradation in its insect vector

Authors: Haitao Wang, Jianhua Zhang, Haoqiu Liu, Man Wang, Yan Dong, Yijun Zhou, Sek-Man Wong, Kai Xu, Qiufang Xu

Journal: Autophagy

PubMed ID: 36093594

Doi: 10.1080/15548627.2022.2116676

Products & Services: Proteins, Expression, Isolation and Analysis

HOXB13 facilitates hepatocellular carcinoma progression by activating AKT/mTOR signaling pathway

Authors: Miao Li, Tingting Tan, Yu Geng, Yue Tao, Jie Pan, Jun Zhang, Qin Xu, Han Shen, Lingyun Zuo, Yuxin Chen

Journal: Ann Hepatol

PubMed ID: 36179794

Doi: 10.1016/j.aohep.2022.100759

Products & Services: CRISPR Plasmids

Arabidopsis Ubiquitin-Conjugating Enzymes UBC4, UBC5, and UBC6 Have Major Functions in Sugar Metabolism and Leaf Senescence

Authors: Sheng Wang , Ling Cao , Ian R Willick , Hong Wang , Karen K Tanino

Journal: Int J Mol Sci

PubMed ID: 36232444

Doi: ijms231911143

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Inhibition of Karyopherin β1-Mediated Nuclear Import Disrupts Oncogenic Lineage-Defining Transcription Factor Activity in Small Cell Lung Cancer

Authors: Demetra P Kelenis, Kathia E Rodarte, Rahul K Kollipara, Karine Pozo, Shreoshi Pal Choudhuri, Kyle B Spainhower, Sarah J Wait, Victor Stastny, Trudy G Oliver, Jane E Johnson

Journal: Cancer Res

PubMed ID: 35748745

Doi: 10.1158/0008-5472.CAN-21-3713

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Chondrogenic primed extracellular vesicles activate miR-455/SOX11/FOXO axis for cartilage regeneration and osteoarthritis treatment

Authors: Ye Sun, Jie Zhao, Qiang Wu, Yuxin Zhang, Yongqing You, Wenbo Jiang, Kerong Dai

Journal: NPJ Regen Med

PubMed ID: 36114225

Doi: 10.1038/s41536-022-00250-7

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Proton-driven alternating access in a spinster lipid transporter

Authors: Reza Dastvan, Ali Rasouli, Sepehr Dehghani-Ghahnaviyeh, Samantha Gies, Emad Tajkhorshid

Journal: Nat Commun

PubMed ID: 36055994

Doi: 10.1038/s41467-022-32759-2

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HSC70 is a novel binding partner involved in the capture of immunoglobulins on B cells in the NOD mouse

Authors: Emma Renman, Rifat Ekici, Mia Sundström, Kristina Lejon

Journal: Autoimmunity

PubMed ID: 36120986

Doi: 10.1080/08916934.2022.2117307

Products & Services: Recombinant Proteins

Teaching an old 'doc' new tricks for algal biotechnology: Strategic filter use enables multi-scale fluorescent protein signal detection

Authors: Sergio Gutiérrez, Gordon B Wellman, Kyle J Lauersen

Journal: Front Bioeng Biotechnol

PubMed ID: 36213064

Doi: 10.3389/fbioe.2022.979607

Products & Services: Plasmid DNA Preparation

Molecular study on recombinant cold-adapted, detergent- and alkali stable esterase (EstRag) from Lysinibacillus sp.: a member of family VI.

Authors: Amira A Matrawy, Ahmed I Khalil, Amira M Embaby

Journal: World J Microbiol Biotechnol .

PubMed ID: 36070019

Doi: 10.1007/s11274-022-03402-5

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Screening of glycosylase activity on oxidative derivatives of methylcytosine: Pedobacter heparinus SMUG2 as a formylcytosine- and carboxylcytosine-DNA glycosylase

Authors: Chenyan Chang, Ye Yang, Jing Li, Sung-Hyun Park, Guang-Chen Fang, Chuan Liang, Weiguo Cao

Journal: DNA Repair (Amst)

PubMed ID: 36179537

Doi: 10.1016/j.dnarep.2022.103408

Products & Services: Mammalian Expression

Identification and functional analysis of histone 12-like in red sea bream (Pagrus major)

Authors: Lianfei Song, Maqsood Ahmed Soomro, Lingshu Wang, Yuting Song, Guobin Hu

Journal: Dev Comp Immunol

PubMed ID: 36087785

Doi: 10.1016/j.dci.2022.104529

Products & Services: Proteins, Expression, Isolation and Analysis

Structural basis for directional chitin biosynthesis

Authors: Wei Chen, Peng Cao, Yuansheng Liu, Ailing Yu, Dong Wang, Lei Chen, Rajamanikandan Sundarraj, Zhiguang Yuchi, Yong Gong, Hans Merzendorfer, Qing Yang

Journal: Nature

PubMed ID: 36131020

Doi: 10.1038/s41586-022-05244-5

Products & Services: Recombinant Antibody Expression

Characterization and Expression Analysis of Regeneration-Associated Protein (Aj-Orpin) during Intestinal Regeneration in the Sea Cucumber

Authors: Fang Su, Lina Sun, Xiaoni Li, Wei Cui, Hongsheng Yang

Journal: Mar Drugs

PubMed ID: 36135757

Doi: 10.3390/md20090568

Products & Services: Proteins, Expression, Isolation and Analysis

A member of the tryptophan-rich protein family is required for efficient sequestration of Plasmodium berghei schizonts

Authors: Julie-Anne Gabelich, Josephine Grützke, Florian Kirscht, Oliver Popp, Joachim M Matz, Gunnar Dittmar, Melanie Rug, Alyssa Ingmundson

Journal: PLoS Pathog

PubMed ID: 36126089

Doi: 10.1371/journal.ppat.1010846

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Anti-SARS-CoV-2 immunoadhesin remains effective against Omicron and other emerging variants of concern

Authors: Hadas Cohen-Dvashi, Jonathan Weinstein, Michael Katz, Maayan Eilon-Ashkenazy, Yuval Mor, Amir Shimon, Hagit Achdout, Hadas Tamir, Tomer Israely, Romano Strobelt, Maya Shemesh, Liat Stoler-Barak, Ziv Shulman, Nir Paran, Sarel Jacob Fleishman, Ron Diskin

Journal: iScience

PubMed ID: 36188189

Doi: 10.1016/j.isci.2022.105193

Products & Services: Mammalian Expression

Acetylated HOXB13 Regulated Super Enhancer Genes Define Therapeutic Vulnerabilities of Castration-Resistant Prostate Cancer

Authors: Duy T Nguyen, Wei Yang, Arun Renganathan, Cody Weimholt, Duminduni H Angappulige, Thanh Nguyen, Robert W Sprung, Gerald L Andriole, Eric H Kim, Nupam P Mahajan, Kiran Mahajan

Journal: Clin Cancer Res

PubMed ID: 35849143

Doi: 10.1158/1078-0432.CCR-21-3603

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A lentiviral vector expressing a dendritic cell-targeting multimer induces mucosal anti-mycobacterial CD4 T-cell immunity

Authors: François Anna, Jodie Lopez, Fanny Moncoq, Catherine Blanc, Pierre Authié, Amandine Noirat, Ingrid Fert, Philippe Souque, Fabien Nevo, Alexandre Pawlik, David Hardy, Sophie Goyard, Denis Hudrisier, Roland Brosch, Françoise Guinet, Olivier Neyrolles, Pierre Charneau, Laleh Majlessi

Journal: Mucosal Immunol

PubMed ID: 36104497

Doi: 10.1038/s41385-022-00566-z

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Kinetic Characterization and Inhibition of Hypoxanthine-Guanine Phosphoribosyltransferases

Authors: Kayla Glockzin, Demetrios Kostomiris, Yacoba V T Minnow, Kajitha Suthagar, Keith Clinch, Sinan Gai, Joshua N Buckler, Vern L Schramm, Peter C Tyler, Thomas D Meek, Ardala Katzfuss

Journal: Biochemistry

PubMed ID: 36193631

Doi: 10.1021/acs.biochem.2c00312

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Impedimetric and amperometric genosensors for the highly sensitive quantification of SARS-CoV-2 nucleic acid using an avidin-functionalized multi-walled carbon nanotubes biocapture platform

Authors: Michael López Mujica, Alejandro Tamborelli, Andrés Castellaro, Danilo Barcudi, María D Rubianes, Marcela C Rodríguez, Héctor A Saka, José L Bocco, Pablo R Dalmasso, Gustavo A Rivas

Journal: Biosens Bioelectron X

PubMed ID: 36118917

Doi: 10.1016/j.biosx.2022.100222

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PpZAT10 negatively regulates peach cold resistance predominantly mediated by inhibiting VIN activity

Authors: YiChen ,JiachangSun ,YingyingWei ,KefengCao ,ShuJiang ,XingfengShao

Journal: Postharvest Biology and Technology

Doi: 10.1016/j.postharvbio.2022.111952

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Non-viral，specifically targeted CAR-T cells achieve high safety and efficacy in B-NHL

Authors: Jiqin Zhang , Yongxian Hu , Jiaxuan Yang , Wei Li , Mingming Zhang , Qingcan Wang , Linjie Zhang , Guoqing Wei , Yue Tian , Kui Zhao , Ang Chen , Binghe Tan , Jiazhen Cui , Deqi Li , Yi Li , Yalei Qi , Dongrui Wang , Yuxuan Wu , Dali Li , Bing Du , Mingyao Liu , He Huang

Journal: Nature

PubMed ID: 36045296

Doi: 10.1038/s41586-022-05140-y

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Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES.

Authors: Zuben P Brown , Irina S Abaeva , Swastik De , Christopher U T Hellen , Tatyana V Pestova , Joachim Frank

Journal: EMBO J

PubMed ID: 35822879

Doi: 10.15252/embj.2022110581

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