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Validation and Invalidation of SARS-CoV-2 Papain-like Protease Inhibitors

Authors: Chunlong Ma; Jun Wang

Journal: ACS pharmacology & translational science

PubMed ID: 35178512

Doi: 10.1021/acsptsci.1c00240

Validation and Invalidation of SARS-CoV-2 Papain-like Protease Inhibitors

Authors: Chunlong Ma; Jun Wang

Journal: ACS pharmacology & translational science

PubMed ID: 35178512

Doi: 10.1021/acsptsci.1c00240

De N ovo -Designed Miniprotein Inhibits the Enzymatic Activity of the SARS-CoV 2 Main Protease

Authors: Tayn E. Lima; Emerson G. Moreira; Danilo F. Co lho; Carlos H. B. Cruz; Rafael Dhalia; Bruno H. S. Leite; L cya S. Xavier; Marta Perez Illana; Gabriel L. Wallau; Isabelle F. T. Viana; Roberto D. Lins

Journal: Journal of chemical information and modeling

PubMed ID: 41060276

Doi: 10.1021/acs.jcim.5c01708

The Sobering Sting: Oleoyl Serotonin Is a Novel Stephanoconus Snail Venom-Derived Antagonist of Cannabinoid Receptors That Counteracts Learning and Memory Deficits

Authors: Dongchen An; Guilherme Salgado Carrazoni; Ben-Hur Souto das Neves; Rudi D Hooge; Steve Peigneur; Jan Tytgat

Journal: Biomedicines

PubMed ID: 38398056

Doi: 10.3390/biomedicines12020454

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Genetics of cystogenesis in base edited human organoids reveal therapeutic strategies for polycystic kidney disease

Authors: Courtney E. Vishy; Chardai Thomas; Thomas Vincent; Daniel K. Crawford; Matthew M. Goddeeris; Benjamin S. Freedman

Journal: Cell Stem Cell

PubMed ID: 38579684

Doi: 10.1016/j.stem.2024.03.005

Products & Services: Plasmid DNA Preparation

Genetics of cystogenesis in base edited human organoids reveal therapeutic strategies for polycystic kidney disease

Authors: Courtney E. Vishy; Chardai Thomas; Thomas Vincent; Daniel K. Crawford; Matthew M. Goddeeris; Benjamin S. Freedman

Journal: Cell Stem Cell

PubMed ID: 38579684

Doi: 10.1016/j.stem.2024.03.005

Products & Services: Plasmid DNA Preparation

In vitro characterization of the catalytic domain of human histone deacetylase 5

Authors: Christian Mammen; Fenja M. Hornung; Christian Anzenhofer; Julia Schumacher; Jens Reiners; Jingyu Li; Flaminia Mazzone; Florestan L. Bilsing; Matthias U. Kassack; Thomas Kurz; Sander H. J. Smits

Journal: Scientific REPORTS

PubMed ID: 41760657

Doi: 10.1038/s41598-026-37633-5

In vitro characterization of the catalytic domain of human histone deacetylase 5

Journal: Scientific REPORTS

PubMed ID: 41760657

Doi: 10.1038/s41598-026-37633-5

In vitro characterization of the catalytic domain of human histone deacetylase 5

Journal: Scientific REPORTS

PubMed ID: 41760657

Doi: 10.1038/s41598-026-37633-5

Torsional Twist of the SARS-CoV and SARS-CoV-2 SUD-N and SUD-M domains

Authors: Monica Rosas-Lemus; George Minasov; Joseph S. Brunzelle; Taha Y. Taha; Sofia Lemak; Shaohui Yin; Ludmilla Shuvalova; Julia Rosecrans; Kanika Khanna; H Steven Seifert; Alexei Savchenko; Peter J. Stogios; Melanie Ott; Karla J. F. Satchell

Journal: biorxiv

PubMed ID: 39185168

Doi: 10.1101/2024.08.13.607777

Early CD4+ T-cell immune reconstitution as a biomarker for Epstein-Barr virus control following allogeneic transplantation

Authors: Kexin Lin, Wenwen Yang, Jiaxiu Yin, Jing Luo, Hao Zhou, Lanxiang Liu, Li Yang, Jie Luo, Lin Liu, Junli Mou

Journal: Blood research

PubMed ID: 41186900

Doi: 10.1007/s44313-025-00106-1

Products & Services: Molecular Biology Reagents

Double-stranded DNA deaminase DddAE1347A can increase the efficiency and targeting range of cytidine base editors

Authors: Yuqiang Qian, Fengjiao Hui, Wenchao Niu, Di Wang, Yang Hao, Qingying Meng, Siyu Ren, Deqiang Kong, Heng Gong, Jiayu Wu, Kexin Chen, Muna Alariqi, Junping Gao, Zhanjun Li, Shuangxia Jin

Journal: Genome Biology

PubMed ID: 41250247

Doi: 10.1186/s13059-025-03849-3

Products & Services: CRISPR RNAs/Cas9 Proteins(INACTIVE)

Glutathionylated DNA adducts accumulate in mitochondrial DNA and are regulated by AP endonuclease 1 and tyrosyl-DNA phosphodiesterase 1

Authors: Yu Hsuan Chen, Martin Esparza Sanchez, Ta I Hung, Jin Tang, Wenyan Xu, Jiekai Yin, Yinsheng Wang, Chia-En A Chang, Huimin Zhang, Junjie Chen, Linlin Zhao

Journal: Proceedings of the National Academy of Sciences of the United States of America

PubMed ID: 41259143

Doi: doi.org/10.1073/pnas.2509312122

Products & Services: Catalog Antibodies

Engineering Multicellular Inter-communication Systems Using a Synthetic Homodimer-inducible Kinase Receptor

Authors: Quan Zhang, Miao Zhang, Yao Zhang, Fenglin Wang, Jian-Hui Jiang

Journal: Angewandte Chemie (International ed. in English)

PubMed ID: 41267507

Doi: 10.1002/anie.202513254

Products & Services: PCR Cloning and Subcloning DNA Sequencing

SLC7A11-independent disulfidptosis induced by a two-pronged delivery strategy for bladder cancer chemotherapy and cisplatin-resistance reverse

Authors: Bin Zheng, Facai Zhang, Heng Wang, Wenyan Zuo, Dingyi Liu, Zhihan Wu, Zhenghong Liu, Haichang Li, Yang Liu, Yixuan Mou, Xiaowen Qin, Dahong Zhang, Pu Zhang, Qi Zhang

Journal: Materials today. Bio

PubMed ID: 41322137

Doi: 10.1016/j.mtbio.2025.102547

Products & Services: Protein and Antibody Isolation

Unveiling conformation-selective regulation of the norepinephrine transporter

Authors: Heng Zhang, Tianwei Zhang, Dingyan Wang, Antao Dai, Jianhang Mao, Qihui Chen, Tianyuan Du, Xue Lu, Yongxin Hao, Chao Zhang, Yu-Ling Yin, Wen Hu, Benxun Pan, Sanshan Jin, Mengting Jiang, Yuan Si, Qingning Yuan, Ming-Wei Wang, Mingyue Zheng, Zhen Wang, Dehua Yang, H Eric Xu, Yi Jiang

Journal: Cell

PubMed ID: 41138730

Doi: 10.1016/j.cell.2025.10.002

Products & Services: Protein and Antibody Isolation

Structure of the human astrovirus capsid spike in complex with the neonatal Fc receptor

Authors: Adam Lentz, Sarah Lanning, Khurshid R Iranpur, Lena Ricemeyer, Carlos F Arias, Rebecca M DuBois

Journal: Nature Communications

PubMed ID: 41184319

Doi: 10.1038/s41467-025-65203-2.

Products & Services: Mutagenesis Services

PROTAC repurposing uncovers a noncanonical binding surface that mediates chemical degradation of nuclear receptors

Authors: Andrew D Huber, Wenwei Lin, Young-Hwan Jung, Shyaron Poudel, Guangwei Yang, Jing Wu, Annalise G Carrigan, Vishwajeeth Pagala, Wei Wang, Yingxue Fu, Zuo-Fei Yuan, Stephanie D Byrum, Ka Yang, Rebecca R Florke Gee, Elizabeth D Arnold, Allister J Loughran, Jingheng Wang, Shondra M Pruett-Miller, Junmin Peng, Taosheng Chen

Journal: Nature Communications

PubMed ID: 41198675

Doi: 10.1038/s41467-025-64773-5.

Products & Services: Bacterial Expression

FUS nanoclusters are a distinct state within the dilute phase

Authors: Yingda Ge, Tapas Paul, Margarita Gordiychuk, Nilimesh Das, Yaojun Zhang, Sua Myong

Journal: Nature Communications

PubMed ID: 41224766

Doi: 10.1038/s41467-025-64909-7.

A fungal pathogen manipulates phytocytokine signaling for plant infection

Authors: Chenlei Hua, Lisha Zhang, Annick Stintzi, Andreas Schaller, Hui-Shan Guo, Thorsten Nürnberger

Journal: Nature Communications

PubMed ID: 41238555

Doi: 10.1038/s41467-025-65934-2.

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Spike conformational and glycan heterogeneity associated with furin cleavage causes incomplete neutralization of SARS-CoV-2

Authors: Sahil Kumar, Rathina Delipan, Chanchal Sharma, Jyoti Jadoun, Kawkab Kanjo, Randhir Singh, Raju Rajmani, Suprit Deshpande, Rajesh Pandey, Krishan G Thakur, Jayanta Bhattacharya, Rogier W Sanders, Marit J van Gils, Raghavan Varadarajan, Rajesh P Ringe

Journal: Nature Communications

PubMed ID: 41257850

Doi: 10.1038/s41467-025-65099-y.

A genome-wide CRISPR screen in Anopheles mosquito cells identifies fitness and immune cell function-related genes

Authors: Enzo Mameli, George-Rafael Samantsidis, Raghuvir Viswanatha, Hyeogsun Kwon, David R Hall, Matthew Butnaru, Yanhui Hu, Stephanie E Mohr, Norbert Perrimon, Ryan C Smith

Journal: Nature Communications

PubMed ID: 41285753

Doi: 10.1038/s41467-025-65304-y.

Products & Services: PCR Cloning and Subcloning

Effective in vivo RNA base editing via engineered cytidine deaminase APOBECs fused with PUF proteins

Authors: Wenjian Han, Bo Yuan, Xiaojuan Fan, Weike Li, Yiting Yuan, Yuefang Zhang, Shu Wang, Shifang Shan, Markus Hafner, Zefeng Wang, Zilong Qiu

Journal: Nature Communications

PubMed ID: 41188225

Doi: 10.1038/s41467-025-64748-6.

Products & Services: Gene Synthesis

Structural snapshots capture nucleotide release at the μ-opioid receptor

Authors: Saif Khan, Aaliyah S Tyson, Mohsen Ranjbar, Zixin Zhang, Jaskaran Singh, Gye Won Han, Cornelius Gati

Journal: Nature

PubMed ID: 41193810

Doi: 10.1038/s41586-025-09677-6.

Products & Services: Catalog Peptides

Engineered CXCR3-A expression enhances B7-H3-targeting CAR T cell migration and efficacy against diffuse intrinsic pontine glioma

Authors: Edward Z Song, Andrea Timpanaro, Michael Meechan, Leonel Elena-Sanchez, Lucy Z Li, Sophie Jamet, Davina S Lau, Lily I Winter, Matthew D Dun, Jessica B Foster, Myron K Evans, Siobhan S Pattwell, Vandana Kalia, Surojit Sarkar, Michael C Jensen, Matthew C Biery, Nicholas A Vitanza

Journal: Nature Communications

PubMed ID: 41219209

Doi: 10.1038/s41467-025-64861-6.

Products & Services: Protein and Antibody Isolation

Wild-type KRAS activation drives evasion of interferon-mediated immunity and resistance to immunotherapy in hepatocellular carcinoma

Authors: Martina Mang Leng Lei, Carmen Oi Ning Leung, Rainbow Wing Hei Leung, Xue Qian Wu, Katherine Po Sin Chung, Catherine Yu Jia Gu, Mandy Sze Man Chan, Wing Ki Chau, Quan Hua Mu, Kai Yu Ng, Man Tong, Jing Ping Yun, Jia Ming Nickolas Teo, Guang Sheng Ling, Patrick Pak Chun Wong, Stephen Lam Chan, Zhe Wen Xiong, Alfred Sze Lok Cheng, Jin Ding, Stephanie Ma, Terence Kin Wah Lee

Journal: Nature Communications

PubMed ID: 41219194

Doi: 10.1038/s41467-025-64860-7.

Products & Services: Mutagenesis Services

Glycerol-3-phosphate activates ChREBP, FGF21 transcription and lipogenesis in citrin deficiency

Authors: Vinod Tiwari, Byungchang Jin, Olivia Sun, Edwin D J Lopez Gonzalez, Min-Hsuan Chen, Xiwei Wu, Hardik Shah, Andrew Zhang, Mark A Herman, Cassandra N Spracklen, Russell P Goodman, Charles Brenner

Journal: Nature metabolism

PubMed ID: 41238906

Doi: 10.1038/s42255-025-01399-3.

Control of Mycobacterium tuberculosis protein secretion by ESX-4 and the outer membrane EsxUT-EsxEF complex

Authors: Rashmi Ravindran Nair, Virginia Meikle, Swati Dubey, Mikhail Pavlenok, Anna D Tischler, Michael Niederweis

Journal: Nature Communications

PubMed ID: 41266320

Doi: 10.1038/s41467-025-65061-y.

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Interpretable molecular decision-making with DNA-based scalable and memory-efficient tree computation

Authors: Junlan Liu, Qian Tang, Yongqi Han, Jinxing Song, Fei Wang, Pei Guo, Chunhai Fan, Weihong Tan, Da Han

Journal: Nature Communications

PubMed ID: 41271734

Doi: 10.1038/s41467-025-66610-1.

High expression of interleukin-18 receptor alpha correlates with severe respiratory viral disease and defines T cells with reduced cytotoxic signatures

Authors: Aira F Cabug, Jeremy Chase Crawford, Hayley A McQuilten, Isabelle J H Foo, Lilith F Allen, Deborah Gebregzabher, Robert C Mettelman, Tanya Novak, Janet Chou, Louise C Rowntree, Ruth R Hagen, Abby J Thomson, Genevieve E Martin, Brad Gilbertson, Michael Nt Souter, Fiona James, Emma Goodall, Simone Rizzetto, Tim Flerlage, Xiaoxiao Jia, Lee-Ann Van de Velde, So Young Chang, Fabio Luciani, Ryan S Thwaites, Jason A Trubiano, Tom C Kotsimbos, Allen C Cheng, Adrienne G Randolph, Paul G Thomas, Jianqing Xu, Zhongfang Wang, Thi H O Nguyen, Brendon Y Chua, Lukasz Kedzierski, Katherine Kedzierska

Journal: Nature Communications

PubMed ID: 41285788

Doi: 10.1038/s41467-025-65262-5.

Products & Services: Peptide Synthesis

Comparative analysis of adenovirus, mRNA, and protein vaccines reveals context-dependent immunogenicity and efficacy

Authors: Bakare Awakoaiye, Shiyi Li, Sarah Sanchez, Tanushree Dangi, Nahid Irani, Laura Arroyo, Gabriel Arellano, Shadi Mohammadabadi, Malika Aid, Pablo Penaloza-MacMaster

Journal: JCI Insight

PubMed ID: 41212056

Doi: 10.1172/jci.insight.198069

Products & Services: Custom mRNA synthesis

Genome-Wide Identification of GW5-LIKE Family Revealed the Function of ClGL1 Involved in Fruit and Seed Shape by Mediating Brassinosteroid Signaling in Watermelon

Authors: Peng Tian, Lei Zhang, Jingjing Zhang, Bowen Liu, Wei Liu, Bing Li, Xiurui Gao, Jie Zhang, Yanrong Wu, Yong Xu

Journal: Horticulturae

Doi: 10.3390/horticulturae11111326

Products & Services: Custom DNA/RNA Oligos

TNC-targeted CAR-macrophage therapy alleviates liver fibrosis in mice

Authors: Kai-Zhao Chen, Zi-Yang Lin, Long-Jun Chen, You-Xi Zhou, Wei Zhang, Hao-Yang Wan, Yong-Kun Huo, Qi Fu, Zi-Qing Gao, Hong-Wei Cheng, Xiao-Dong Ma, Shuai-Shuai Zhang

Journal: Military Medical Research

PubMed ID: 41214839

Doi: 10.1186/s40779-025-00667-3

Products & Services: Protein and Antibody Isolation

Double-stranded DNA deaminase DddAE1347A can increase the efficiency and targeting range of cytidine base editors

Authors: Yuqiang Qian, Fengjiao Hui, Wenchao Niu, Di Wang, Yang Hao, Qingying Meng, Siyu Ren, Deqiang Kong, Heng Gong, Jiayu Wu, Kexin Chen, Muna Alariqi, Junping Gao, Zhanjun Li, Shuangxia Jin

Journal: Genome Biology

PubMed ID: 41250247

Doi: doi.org/10.1186/s13059-025-03849-3

Products & Services: Gene Fragments

RBM39 Contributes to MGMT Maintenance in Response to Temozolomide-Induced DNA Damage

Authors: Vahid Khalaj, Jack T Adams, Solmaz AghaAmiri, Servando Hernandez Vargas, Tyler M Bateman, Sukhen C Ghosh, Majid Momeny, Ali Azhdarinia

Journal: Cancers

PubMed ID: 41300971

Doi: 10.3390/cancers17223604

Products & Services: Protein Electrophoresis and Western

Amplification-free cancer diagnosis based on inhibition of Cas12a activity by site-specific 5mC-modified cfDNA

Authors: Feng Yang, Can Xu, Chunhong Li, Xinni Xiang, Yi Zhao, Cong Hu, Huan Rong, Yu He, Jingyu Li, Yu Wang, Chao Tang, Xiaoyu Liu, Renyan Li, Fei Deng, Tingxiu Xiang

Journal: Nucleic Acids Research

PubMed ID: 41404798

Doi: doi.org/10.1093/nar/gkaf1383

Products & Services: Catalog Gene Editing

Intravaginal delivery of mRNA-encoded antibodies with enhanced breadth and potency for SHIV/HIV protection

Authors: Jae Yeon Joo, Peng Xiao, Susan P John, Daryll Vanover, Hannah E Peck, Loren E Sasser, Deepanwita Bose, Younghun Jung, Jaehyeon Hwang, Chiara Zurla, Francois Villinger, Philip J Santangelo

Journal: Nature Communications

PubMed ID: 41290645

Doi: doi.org/10.1038/s41467-025-65456-x

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Nonexpansive biodegradable matrix promotes blood vessel organoid development for neurovascular repair and functional recovery in ischaemic stroke

Authors: Dongling Xiao, Yue Sun, Guanyuan Yang, Weixi Yan, Meilin Jiang, Zhongliang Qin, Zijun Wang, Yawei Gu, Jingting Zhou, Ju Tan, Gang Li, Yinghao Li, Chuhong Zhu

Journal: Nature biomedical engineering

PubMed ID: 41184604

Doi: 10.1038/s41551-025-01550-1

Products & Services: Peptide Library Services

TIPIN coordinates ATM-dependent checkpoint and NF-κB signaling to counteract DNA replication damage from topoisomerase inhibition

Authors: Arafat Khan, Justin F Lim, Natalie Lo, Jinal A Patel, John Haley, Hyungjin Kim

Journal: Communications biology

PubMed ID: 41291151

Doi: 10.1038/s42003-025-09084-7

Products & Services: Polyclonal Antibody Services

The Sobering Sting: Oleoyl Serotonin Is a Novel Stephanoconus Snail Venom-Derived Antagonist of Cannabinoid Receptors That Counteracts Learning and Memory Deficits

Authors: Dongchen An; Guilherme Salgado Carrazoni; Ben-Hur Souto das Neves; Rudi D Hooge; Steve Peigneur; Jan Tytgat

Journal: Biomedicines

PubMed ID: 38398056

Doi: 10.3390/biomedicines12020454

Products & Services: Custom Vector Construction

Genetics of cystogenesis in base edited human organoids reveal therapeutic strategies for polycystic kidney disease

Authors: Courtney E. Vishy; Chardai Thomas; Thomas Vincent; Daniel K. Crawford; Matthew M. Goddeeris; Benjamin S. Freedman

Journal: Cell Stem Cell

PubMed ID: 38579684

Doi: 10.1016/j.stem.2024.03.005

Products & Services: Plasmid DNA Preparation

De N ovo -Designed Miniprotein Inhibits the Enzymatic Activity of the SARS-CoV 2 Main Protease

Journal: Journal of chemical information and modeling

PubMed ID: 41060276

Doi: 10.1021/acs.jcim.5c01708

Genetics of cystogenesis in base edited human organoids reveal therapeutic strategies for polycystic kidney disease

Authors: Courtney E. Vishy; Chardai Thomas; Thomas Vincent; Daniel K. Crawford; Matthew M. Goddeeris; Benjamin S. Freedman

Journal: Cell Stem Cell

PubMed ID: 38579684

Doi: 10.1016/j.stem.2024.03.005

Products & Services: Plasmid DNA Preparation

Torsional Twist of the SARS-CoV and SARS-CoV-2 SUD-N and SUD-M domains

Journal: biorxiv

PubMed ID: 39185168

Doi: 10.1101/2024.08.13.607777

Torsional Twist of the SARS-CoV and SARS-CoV-2 SUD-N and SUD-M domains

Journal: biorxiv

PubMed ID: 39185168

Doi: 10.1101/2024.08.13.607777

On-target off-tumor toxicity of claudin18.2-directed CAR-T cells in preclinical models

Authors: Filippo Birocchi, Antonio J Almazan, Aiyana Parker, Amanda A Bouffard, Sadie Goncalves, Christopher Kelly, Jessica Frank, Mark B Leick, Nicholas J Haradhvala, Shaw Kagawa, Gad Getz, Giulia Escobar, Diego Salas-Benito, Adele Mucci, Trisha R Berger, Marcela V Maus

Journal: Nature Communications

PubMed ID: 41176533

Doi: 10.1038/s41467-025-61858-z.

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Generation of antigen-specific paired-chain antibodies using large language models

Authors: Perry T Wasdin, Nicole V Johnson, Alexis K Janke, Sofia Held, Toma M Marinov, Gwen Jordaan, Rebecca A Gillespie, Léna Vandenabeele, Fani Pantouli, Olivia C Powers, Matthew J Vukovich, Clinton M Holt, Jeongryeol Kim, Grant Hansman, Jennifer Logue, Helen Y Chu, Sarah F Andrews, Masaru Kanekiyo, Giuseppe A Sautto, Ted M Ross, Daniel J Sheward, Jason S McLellan, Alexandra A Abu-Shmais, Ivelin S Georgiev

Journal: Cell

PubMed ID: 41192421

Doi: 10.1016/j.cell.2025.10.006.

Products & Services: Protein and Antibody Isolation

A plastid carbohydrate carrier mediates ribose recycling from nucleotide catabolism and glucose export from starch degradation

Authors: Luisa Voß, Isabel Keller, Rebekka Schröder, Denise Mehner-Breitfeld, André Specht, Gerald Dräger, Jannis Rinne, Jakob Franke, Nieves Medina-Escobar, Marco Herde, Thomas Brüser, H Ekkehard Neuhaus, Claus-Peter Witte

Journal: Nature Communications

PubMed ID: 41193506

Doi: 10.1038/s41467-025-65510-8

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Structural and functional characterization of TgGSK3, a druggable kinase in Toxoplasma gondii

Authors: Silvia Diaz-Martin, Christopher Swale, Valeria Bellini, Irina Dobrescu, Janine Wenker, Marie-Pierre Brenier-Pinchart, Laurence Braun, Alwéna Tollec, Charlotte Corrao, Yohann Couté, Caroline Mas, Fabrice Laurent, Matthew Bowler, Mohamed-Ali Hakimi, Alexandre Bougdour

Journal: Nature Communications

PubMed ID: 41193440

Doi: 10.1038/s41467-025-64701-7.

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A chromosome-level genome of Astilbe chinensis unveils the evolution of a terpene biosynthetic gene cluster

Authors: Fangfang Chen, Yan Yao, Hangzhi Zhu, Jie Hu, Aohan Geng, Zhenni Xu, Xueting Fang, Weijia Cheng, Yao Zhi, Yonghong Zhang, Zixin Deng, Tiangang Liu, Li Lu

Journal: Nature Communications

PubMed ID: 41213911

Doi: 10.1038/s41467-025-64842-9.

Products & Services: Protein and Antibody Isolation