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GASP: A Pan-Specific Predictor of Family 1 Glycosyltransferase Acceptor Specificity Enabled by a Pipeline for Substrate Feature Generation and Large-Scale Experimental Screening

Authors: David Harding-Larsen, Christian Degnbol Madsen, David Teze, Tiia Kittilä, Mads Rosander Langhorn, Hani Gharabli, Mandy Hobusch, Felipe Mejia Otalvaro, Onur Kırtel, Gonzalo Nahuel Bidart, Stanislav Mazurenko, Evelyn Travnik, Ditte Hededam Welner

Journal: ACS Omega

PubMed ID: 38947828

Doi: 10.1021/acsomega.4c01583

Products & Services: Gene Synthesis

Population differentiation and dynamics of five pioneer species of Gaultheria from the secondary forests in subtropical China

Authors: Yi-Rong Li, Peter W Fritsch, Gui-Gang Zhao, Xiao-Juan Cheng, Zhao-Li Ding, Lu Lu

Journal: BMC Plant Biol

PubMed ID: 38851686

Doi: 10.1186/s12870-024-05189-z

Products & Services: PCR Cloning and Subcloning

CircSCNN1A inhibits the proliferation, migration and invasion of renal cell carcinoma cells by decreasing CLDN8 expression through miR-590-5p

Authors: Tingting Guo, Wanjuan Xiong, Chong Liu, Li Zhu, Ling Xie

Journal: Genesis

PubMed ID: 38764323

Doi: 10.1002/dvg.23599

Products & Services: Mutant Libraries

N-terminal cysteine acetylation and oxidation patterns may define protein stability

Authors: Karen C Heathcote, Thomas P Keeley, Matti Myllykoski, Malin Lundekvam, Nina McTiernan, Salma Akter, Norma Masson, Peter J Ratcliffe, Thomas Arnesen, Emily Flashman

Journal: Nat Commun

PubMed ID: 38918375

Doi: 10.1038/s41467-024-49489-2

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Evolutionary history and activity towards oligosaccharides and polysaccharides of GH3 glycosidases from an Antarctic marine bacterium

Authors: Alessandro Marchetti, Marco Orlando, Luca Bombardi, Salvatore Fusco, Marco Mangiagalli, Marina Lotti

Journal: Int J Biol Macromol

PubMed ID: 38944065

Doi: 10.1016/j.ijbiomac.2024.133449

Products & Services: Gene Synthesis

A Streptococcus pneumoniae endolysin mutant protein ΔA146Ply elicits rapid broad-spectrum mucosal protection in mice via upregulation of GPX4 through TLR4/IRG1/NRF2 to alleviate macrophage ferroptosis

Authors: Yuan Yuan, Wenlong Xu, Lian Li, Ting Guo, Bichen Liu, Jiangming Xiao, Yibin Yin, Xuemei Zhang

Journal: Free Radic Biol Med

PubMed ID: 38945457

Doi: 10.1016/j.freeradbiomed.2024.06.025

Products & Services: Molecular Biology Reagents

Andrographolide influences IDD cell autophagy and oxidative stress under mechanical pressure via miR-9/FoxO3/PINK1/Parkin molecular axis

Authors: Jianwei Liu, Dixing Lin, Jiadong Lu

Journal: Cell Mol Biol (Noisy-le-grand)

PubMed ID: 38836662

Doi: 10.14715/cmb/2024.70.6.29

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Characterization of a novel carboxylesterase from Streptomyces lividans TK24 and site-directed mutagenesis for its thermostability

Authors: Jinxin Fang, Lihua An, Jiao Yu, Jinxue Ma, Rongjie Zhou, Baojuan Wang

Journal: J Biosci Bioeng

PubMed ID: 38871580

Doi: 10.1016/j.jbiosc.2024.05.001

Products & Services: Proteins, Expression, Isolation and Analysis

Nonclinical immunogenicity risk assessment for knobs-into-holes bispecific IgG antibodies

Authors: Wen-Ting K Tsai, Yinyin Li, Zhaojun Yin, Peter Tran, Qui Phung, Zhenru Zhou, Kun Peng, Dan Qin, Sien Tam, Christoph Spiess, Jochen Brumm, Manda Wong, Zhengmao Ye, Patrick Wu, Sivan Cohen, Paul J Carter

Journal: MAbs

PubMed ID: 38845069

Doi: 10.1080/19420862.2024.2362789

Products & Services: Gene Synthesis

Neutralizing antibodies reveal cryptic vulnerabilities and interdomain crosstalk in the porcine deltacoronavirus spike protein

Authors: Wenjuan Du, Oliver Debski-Antoniak, Dubravka Drabek, Rien van Haperen, Melissa van Dortmondt, Joline van der Lee, Ieva Drulyte, Frank J M van Kuppeveld, Frank Grosveld, Daniel L Hurdiss, Berend-Jan Bosch

Journal: Nat Commun

PubMed ID: 38909062

Doi: 10.1038/s41467-024-49693-0

Products & Services: DNA Sequencing

Down-regulation of SLC14A1 in prostate cancer activates CDK1/CCNB1 and mTOR pathways and promotes tumor progression

Authors: Jianbin Ma, Kaihua Xue, Yifan Jiang, Xinyang Wang, Dalin He, Peng Guo

Journal: Sci Rep

PubMed ID: 38942821

Doi: 10.1038/s41598-024-66020-1

Products & Services: Molecular Biology Reagents

Protein disulfide isomerase is essential for spermatogenesis in mice

Authors: Yaqiong Zhang, Aizhen Yang, Zhenzhen Zhao, Fengwu Chen, Xiaofeng Yan, Yue Han, Depei Wu, Yi Wu

Journal: JCI Insight

PubMed ID: 38912589

Doi: 10.1172/jci.insight.177743

Products & Services: Proteins, Expression, Isolation and Analysis

RBD design increases the functional antibody titers elicited by SARS-CoV-2 spike vaccination

Authors: Thayne H Dickey, Nichole D Salinas, Palak Patel, Sachy Orr-Gonzalez, Tarik Ouahes, Holly McAleese, Brandi L Richardson, Myesha Singleton, Michael Murphy, Brett Eaton, Jennifer L Kwan, Michael R Holbrook, Lynn E Lambert, Niraj H Tolia

Journal: Antiviral Res

PubMed ID: 38901738

Doi: 10.1016/j.antiviral.2024.105937

Products & Services: Proteins, Expression, Isolation and Analysis

Integrated metabolomics and transcriptomics reveal that HhERF9 positively regulates salt tolerance in Hibiscus hamabo Siebold & Zuccarini

Authors: Longjie Ni, Yu Xu, Zhiquan Wang, Chaoguang Yu, Jianfeng Hua, Yunlong Yin, Huogen Li, Chunsun Gu

Journal: Plant Physiol Biochem

PubMed ID: 38879985

Doi: 10.1016/j.plaphy.2024.108843

Products & Services: Proteins, Expression, Isolation and Analysis

Human cytomegalovirus deploys molecular mimicry to recruit VPS4A to sites of virus assembly

Authors: Benjamin G Butt, Daniela Fischer, Alison R Rep, Martin Schauflinger, Clarissa Read, Thomas Böck, Manuel Hirner, Frederik Wienen, Stephen C Graham, Jens von Einem

Journal: PLoS Pathog

PubMed ID: 38900818

Doi: 10.1371/journal.ppat.1012300

Products & Services: Proteins, Expression, Isolation and Analysis

Detection of avian reovirus (ARV) by ELISA based on recombinant σB, σC and σNS full-length proteins and protein fragments

Authors: Tatiana Reichert Assunção de Matos, Ana Paula Gori Palka, Claudemir de Souza, Stenio Perdigão Fragoso, Daniela Parada Pavoni

Journal: J Med Microbiol

PubMed ID: 38935078

Doi: 10.1099/jmm.0.001836

Products & Services: Gene Synthesis

Discovery and Characterization of Two Folded Intermediates for Outer Membrane Protein TolC Biogenesis

Authors: Ayotunde Paul Ikujuni, Rik Dhar, Andres Cordova, Alexander M Bowman, Sarah Noga, Joanna S G Slusky

Journal: J Mol Biol

PubMed ID: 38871177

Doi: 10.1016/j.jmb.2024.168652

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Systematic identification and functional analysis of root meristem growth factors (RGFs) reveals role of PgRGF1 in modulation of root development and ginsenoside production in Panax ginseng

Authors: Weipeng Lian, Linfan Zhang, Chenglin Wang, Shiqi Wu, Shan He, Jinlin Lei, Yonghong Zhang, Lei You, Lanlan Zheng, Xiangyin Luo, Zhengxiu Ye, Ziyao Hu, Guodong Wang, Yun Zhu, Chen Li, Juan Liu

Journal: Int J Biol Macromol

PubMed ID: 38945337

Doi: 10.1016/j.ijbiomac.2024.133446

Products & Services: Gene Synthesis

AGC kinases OXI1 and AGC2-2 regulate camalexin secretion and disease resistance by phosphorylating transporter PDR6

Authors: Juan Han, Chang-Xin Liu, Jian Liu, Cheng-Run Wang, Shun-Chang Wang, Guopeng Miao

Journal: Plant Physiol

PubMed ID: 38535832

Doi: 10.1093/plphys/kiae186

Products & Services: Proteins, Expression, Isolation and Analysis

Seeding activity of human superoxide dismutase 1 aggregates in familial and sporadic amyotrophic lateral sclerosis postmortem neural tissues by real-time quaking-induced conversion

Authors: Justin K. Mielke, Mikael Klingeborn, Eric P. Schultz, Erin L. Markham, Emily D. Reese, Parvez Alam, Ian R. Mackenzie, Cindy V. Ly, Byron Caughey, Neil R. Cashman & Moses J. Leavens

Journal: Acta Neuropathologica

PubMed ID: 38884646

Doi: 10.1007/s00401-024-02752-8

Products & Services: DNA Sequencing

Structural insights into somatostatin receptor 5 bound with cyclic peptides

Authors: Ying-Ge Li, Xian-Yu Meng, Xiru Yang, Sheng-Long Ling, Pan Shi, Chang-Lin Tian, Fan Yang

Journal: Acta Pharmacol Sin

PubMed ID: 38926478

Doi: 10.1038/s41401-024-01314-8

Products & Services: Proteins, Expression, Isolation and Analysis

Receptor-like kinase ERECTA negatively regulates anthocyanin accumulation in grape

Authors: Bo Wang, Qianqian Pang, Yunzhi Zhou, Jungui Yang, Ehsan Sadeghnezhad, Yuanxin Cheng, Sihong Zhou, Haifeng Jia

Journal: Plant Sci

PubMed ID: 38942388

Doi: 10.1016/j.plantsci.2024.112172

Products & Services: Gene Synthesis

Identification, Synthesis, and In Vitro Activities of Antimicrobial Peptide from African Catfish against the Extended-Spectrum Beta-Lactamase (ESBL)-Producing Escherichia coli

Authors: Hedmon Okella , Steven Odongo , Didier Vertommen , Emmanuel Okello

Journal: Pharmaceutics

PubMed ID: 39065546

Doi: 10.3390/pharmaceutics16070850

Products & Services: Peptide Synthesis

ATM and ATR gene editing mediated by CRISPR/Cas9 in Chinese Hamster cells

Authors: Junko Maeda , Piyawan Chailapakul , Takamitsu A Kato

Journal: Mutat Res

PubMed ID: 39024734

Doi: 10.1016/j.mrfmmm.2024.111871

Products & Services: CRISPR Plasmids

Lipid-Polymer Nanoparticles Mediate Compartmentalized Delivery of Cas9 and sgRNA for Glioblastoma Vasculature and Immune Reprogramming

Authors: Huaqing Zhang, Wenxin Jiang, Tingting Song, Mingjie Song, Shengyu Liu, Jianping Zhou, Hao Cheng, Yang Ding

Journal: Adv Sci (Weinh)

PubMed ID: 38923275

Doi: 10.1002/advs.202309314

Products & Services: CRISPR RNAs/Cas9 Proteins(INACTIVE)

Puferfsh gasdermin Ea is a signifcant player in the defense against bacterial pathogens

Authors: Hang Xu, Kunpeng Qin, Kangwei Hao, Zihao Yuan & Li Sun

Journal: Marine Life Science & Technology

Doi: //doi.org/10.1007/s42995-024-00237-x

Products & Services: Proteins, Expression, Isolation and Analysis

Self-assembled protein vesicles as vaccine delivery platform to enhance antigen-specific immune responses

Authors: Yirui Li, Mariela R Rodriguez-Otero, Julie A Champion

Journal: Biomaterials

PubMed ID: 38879893

Doi: 10.1016/j.biomaterials.2024.122666

Products & Services: Molecular Biology Reagents

Expanding the genetic toolbox for the obligate human pathogen

Authors: Nina Lautenschläger, Katja Schmidt, Carolin Schiffer, Thomas F Wulff, Karin Hahnke, Knut Finstermeier, Moïse Mansour, Alexander K W Elsholz, Emmanuelle Charpentier

Journal: Front Bioeng Biotechnol

PubMed ID: 38911550

Doi: 10.3389/fbioe.2024.1395659

Products & Services: Gene Synthesis

Novel chymotrypsin C (CTRC) variants from real-world genetic testing of pediatric chronic pancreatitis cases

Authors: Regina Stefanovics, Máté Sándor, Alexandra Demcsák, Gergő Berke, Balázs Csaba Németh, Wenying Zhang, Maisam Abu-El-Haija, Miklós Sahin-Tóth

Journal: Pancreatology

PubMed ID: 38876922

Doi: 10.1016/j.pan.2024.06.003

Products & Services: Gene Synthesis

Mitochondrial DNA transcription and mitochondrial genome-encoded long noncoding RNA in diabetic retinopathy

Authors: Jay Kumar, Renu A Kowluru

Journal: Mitochondrion

PubMed ID: 38944370

Doi: 10.1016/j.mito.2024.101925

Products & Services: Gene Synthesis

An Ochratoxin a DNA Aptamer-Mediated Transcriptional Regulatory Riboswitch Biosensor

Authors: Xiaoze Dong, Shuo Qi, Pengfei Ma, Hongtao Jiang, Mingwei Qin, Ning Ding, Yin Zhang, Zhouping Wang

Journal: J Agric Food Chem

PubMed ID: 38847536

Doi: 10.1021/acs.jafc.4c02968

Products & Services: Recombinant Proteins

APOE2 protects against Aβ pathology by improving neuronal mitochondrial function through ERRα signaling

Authors: Zhiyuan Ning, Ying Liu, Mengyao Wan, You Zuo, Siqi Chen, Zhongshan Shi, Yongteng Xu, Honghong Li, Ho Ko, Jing Zhang, Songhua Xiao, Daji Guo, Yamei Tang

Journal: Cell Mol Biol Lett

PubMed ID: 38867189

Doi: 10.1186/s11658-024-00600-x

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The Interplay of Acetylation and Ubiquitination Controls PRMT1 Homeostasis

Authors: Mohd Altaf Najar, Jenna N Beyer, Callie E W Crawford, George M Burslem

Journal: biorxiv

PubMed ID: 38948822

Doi: 10.1101/2024.06.18.599616

Products & Services: Molecular Biology Reagents

Bioorthogonal non-canonical amino acid tagging to track transplanted human induced pluripotent stem cell-specific proteome

Authors: Divya Sridharan, Julie A Dougherty, Uzair Ahmed, Shridhar K Sanghvi, Syed Baseeruddin Alvi, Ki Ho Park, Helena Islam, Sue E Knoblaugh, Harpreet Singh, Elizabeth D Kirby, Mahmood Khan

Journal: Stem Cell Res Ther

PubMed ID: 38926849

Doi: 10.1186/s13287-024-03792-3

Products & Services: Gene Synthesis

CD70-specific CAR NK cells expressing IL-15 for the treatment of CD19-negative B-cell malignancy

Authors: Shanshan Guo, Wen Lei, Xueli Jin, Hui Liu, James Q Wang, Wenhai Deng, Wenbin Qian

Journal: Blood Adv

PubMed ID: 38564778

Doi: 10.1182/bloodadvances.2023012202

Products & Services: Codon Optimization

Metagenomic exploration of cold-active enzymes for detergent applications: Characterization of a novel, cold-active and alkali-stable GH8 endoglucanase from ikaite columns in SW Greenland

Authors: Bianca Oliva, Athanasios Zervas, Peter Stougaard, Peter Westh, Mariane Schmidt Thøgersen

Journal: Microb Biotechnol

PubMed ID: 38829370

Doi: 10.1111/1751-7915.14466

Products & Services: Gene Synthesis

Comparative Analysis of Orthosteric and Allosteric GLP-1R Agonists' Effects on Insulin Secretion from Healthy, Diabetic, and Recovered INS-1E Pancreatic Beta Cells

Authors: Joshua Reed, Victoria Higginbotham, Stephen Bain, Venkateswarlu Kanamarlapudi

Journal: Int J Mol Sci

PubMed ID: 38928038

Doi: 10.3390/ijms25126331

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Oriented immobilization of nanobodies using SpyCatcher/SpyTag significantly enhances the capacity of affinity chromatography

Authors: Yuxiang Zhang, Yao Zhang, Luyao Zhang, Yongdong Liu

Journal: J Chromatogr A

PubMed ID: 38905946

Doi: 10.1016/j.chroma.2024.465107

Products & Services: Molecular Biology Reagents

The blood-testis barrier disruption is a prerequisite for toxicant-induced peritubular macrophage increases in the testis of peripubertal rats

Authors: Xin Fang, Richa Tiwary, Vivian P Nguyen, John H Richburg

Journal: Toxicol Sci

PubMed ID: 38565259

Doi: 10.1093/toxsci/kfae043

Products & Services: Molecular Biology Reagents

Anticancer Activity of HER2-targeting CPP-PTEN-THP Chimeric Proteins

Authors: Elizeth Pioquinto-Avila, Aldo O González-Cruz, Jorge Solís-Estrada, Javier Hernández-Juarez, Isaías Balderas-Rentería, Sheila Adela Villa-Cedillo, José Juan Pérez-Trujillo, Eder Arredondo-Espinoza

Journal: Anticancer Res

PubMed ID: 38821612

Doi: 10.21873/anticanres.17062

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Investigation of SARS-CoV-2 Infection among Companion Animals in Households with Confirmed Human COVID-19 Cases

Authors: Heather Venkat, Hayley D Yaglom, Gavriella Hecht, Andrew Goedderz, Jennifer L Ely, Michael Sprenkle, Taylor Martins, Daniel Jasso-Selles, Darrin Lemmer, Jordan Gesimondo, Irene Ruberto, Kenneth Komatsu, David M Engelthaler

Journal: Pathogens

PubMed ID: 38921764

Doi: 10.3390/pathogens13060466

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A ternary correlation multi-symptom network strategy based on in vivo chemical profile identification and metabolomics to explore the molecular basis of Ephedra herb against viral pneumonia

Authors: Xiaoyan Wang, Jie Mei, Fan Zhang, Miaomiao Wei, Yujun Xie, Alamusi Bayoude, Xiufeng Liu, Boli Zhang, Boyang Yu

Journal: J Sep Sci

PubMed ID: 38819782

Doi: 10.1002/jssc.202400090

Products & Services: Gene Synthesis

Chemical modification, structure elucidation and antifungal mechanism studies of a peptide extracted from garlic (Allium sativum L)

Authors: Shuqin Li, Junyu Liu, Tingting Zhang, Jingyang Lu, Mingyue Li, Min Zhang, Haixia Chen

Journal: J Sci Food Agric

PubMed ID: 38855916

Doi: 10.1002/jsfa.13633

Products & Services: Peptide Synthesis

Cationic lipid nanoparticle-mediated delivery of a Cas9/crRNA ribonucleoprotein complex for transgene-free editing of the citrus plant genome

Authors: Lamiaa M Mahmoud, Manjul Dutt

Journal: Plant Cell Rep

PubMed ID: 38874819

Doi: 10.1007/s00299-024-03254-3

Products & Services: Proteins, Expression, Isolation and Analysis

Efficient site-specific integration of large genes in mammalian cells via continuously evolved recombinases and prime editing

Authors: Smriti Pandey, Xin D Gao, Nicholas A Krasnow, Amber McElroy, Y Allen Tao, Jordyn E Duby, Benjamin J Steinbeck, Julia McCreary, Sarah E Pierce, Jakub Tolar, Torsten B Meissner, Elliot L Chaikof, Mark J Osborn, David R Liu

Journal: Nat Biomed Eng

PubMed ID: 38858586

Doi: 10.1038/s41551-024-01227-1

Products & Services: Molecular Biology Reagents

Succinate coenzyme A ligase β-like protein from Trichinella spiralis is a potential therapeutic molecule for allergic asthma

Authors: Kalibixiati Aimulajiang, Wen Chu, Shuyi Liao, Zhaohai Wen, Rongdong He, Mingmin Lu, Lixin Xu, Xiaokai Song, Xiangrui Li, Ruofeng Yan

Journal: Immun Inflamm Dis

PubMed ID: 38888451

Doi: 10.1002/iid3.1321

Products & Services: Molecular Biology Reagents

Molecular Mechanism of GmSNE3 Ubiquitin Ligase-Mediated Inhibition of Soybean Nodulation by Halosulfuron Methyl

Authors: Yuanfu Li, Jingsi Qiu, Jingxia Yang, Yihan Li, Hui Zhang, Feng Zhao, Huihua Tan

Journal: J Agric Food Chem

PubMed ID: 38867659

Doi: 10.1021/acs.jafc.4c02621

Products & Services: Catalog Antibody

Three families of CD4-induced antibodies are associated with the capacity of plasma from people living with HIV to mediate ADCC in presence of CD4-mimetics

Authors: Alexandra Tauzin, Lorie Marchitto, Étienne Bélanger, Mehdi Benlarbi, Guillaume Beaudoin-Bussières, Jérémie Prévost, Derek Yang, Ta-Jung Chiu, Hung-Ching Chen, Catherine Bourassa, Halima Medjahed, Marek K Korzeniowski, Suneetha Gottumukkala, William D Tolbert, Jonathan Richard, Amos B Smith, Marzena Pazgier, Andrés Finzi

Journal: medrxiv

PubMed ID: 38883797

Doi: 10.1101/2024.06.02.24308281

Products & Services: Catalog Peptides

Identification of two novel B cell epitopes on E184L protein of African swine fever virus using monoclonal antibodies

Authors: Weldu Tesfagaber, Desong Lan, Wan Wang, Rui Zhao, Li Yin, Mingyang Yang, Yuanmao Zhu, Encheng Sun, Renqiang Liu, Wenjun Lin, Zhigao Bu, Fang Li, Dongming Zhao

Journal: Virus Res

PubMed ID: 38838820

Doi: 10.1016/j.virusres.2024.199412

Products & Services: Gene Synthesis

Neuronal expression of herpes simplex virus-1 VP16 protein induces pseudorabies virus escape from silencing and reactivation

Authors: Zhi-Shan Hsu, Esteban A Engel, Lynn W Enquist, Orkide O Koyuncu

Journal: J Virol

PubMed ID: 38869285

Doi: 10.1128/jvi.00561-24

Products & Services: Proteins, Expression, Isolation and Analysis

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