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A Ubiquitin-Competitive Strategy Based on the Element Microenvironment toTreat Osteoarthritis

Authors: Keyu Kong, Yuqi Yang, Yongyun Chang, Youdong Chen, Xiao Yang, Jiahao Qin, Zhuorun Song, Shunyi Lu, Zanjing Zhai, Jun Ge, Huiwu Li, Liang Cheng

Journal: Advanced Functional Materials

Doi: 10.1002/adfm.202409707

Products & Services: Recombinant Proteins

Highly sensitive and selective electrochemical biosensor using odorant-binding protein to detect aldehydes

Authors: Cong Peng a b, Yutong Sui a, Chaohua Fang a, Hongxu Sun a, Wenxin Liu a, Xinying Li a, Chen Qu a, Wenhui Li a, Jiemin Liu a c, Chuandong Wu a

Journal: Analytica Chimica Acta

Doi: 10.1016/j.aca.2024.342932

Products & Services: PCR Cloning and Subcloning

CLASP-mediated competitive binding in protein condensates directs microtubule growth

Authors: Xuanyan Jia , Leishu Lin, Siqi Guo , Lulu Zhou , Gaowei Jin , Jiayuan Dong , Jinman Xiao , Xingqiao Xie , Yiming Li , Sicong He , Zhiyi Wei , Cong Yu

Journal: Nature Communications

PubMed ID: 39095354

Doi: 10.1038/s41467-024-50863-3

Products & Services: Proteins, Expression, Isolation and Analysis

Simultaneous In Vivo Imaging of Neutrophil Elastase and Oxidative Stress in Atherosclerotic Plaques Using a Unimolecular Photoacoustic Probe

Authors: Yuan Ma , Hui Cao , Baode Chen , Xinyu Xu , Qingpeng Zhang , Haoming Chen , Xiao-Bing Zhang , Guosheng Song

Journal: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PubMed ID: 39115358

Doi: 10.1002/anie.202411840

Products & Services: Peptide Synthesis

A broadly protective antibody targeting glycoprotein Gn inhibits severe fever with thrombocytopenia syndrome virus infection

Authors: Xuanxiu Ren # 1, Jiawen Sun # 2 3, Wenhua Kuang # 2, Feiyang Yu 1, Bingjie Wang 1, Yong Wang 2 3, Wei Deng 2 3, Zhao Xu 2 3, Shangyu Yang 1, Hualin Wang 2 4, Yangbo Hu 2 4, Zengqin Deng 5 6, Yun-Jia Ning 7 8, Haiyan Zhao

Journal: Nature Communications

PubMed ID: 39147753

Doi: 10.1038/s41467-024-51108-z

Products & Services: Proteins, Expression, Isolation and Analysis

Lipid synthesis, triggered by PPARγ T166 dephosphorylation, sustains reparative function of macrophages during tissue repair

Authors: Shiman Zuo , Yuxin Wang , Hanjing Bao , Zehui Zhang , Nanfei Yang , Meng Jia , Qing Zhang , Ani Jian , Rong Ji , Lidan Zhang , Yan Lu , Yahong Huang , Pingping Shen

Journal: Nature Communications

PubMed ID: 39179603

Doi: doi.org/10.1038/s41467-024-51736-5

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Zinc Coordination Lipid Nanoparticles Co-Delivering Calcium Peroxide and Chelating STING agonist for Enhanced Cancer Metalloimmunotherapy

Authors: Qian Qiu , Jiexin Li , He Ren , Jingyu Zhang , Gengqi Liu , Ruiqi Yang , Boyang Sun , Chen Zhang , Yumiao Zhang

Journal: Small

PubMed ID: 39114869

Doi: 10.1002/smll.202402308

Products & Services: Recombinant Proteins

Large-scale genomic investigation of pediatric cholestasis reveals a novel hepatorenal ciliopathy caused by PSKH1 mutations

Authors: Sateesh Maddirevula , Mohammad Shagrani , Ae-Ri Ji , Christopher R Horne , Samuel N Young , Lucy J Mather , Mashael Alqahtani , Colin McKerlie , Geoffrey Wood , Paul K Potter , Firdous Abdulwahab , Tarfa AlSheddi , Wendy L van der Woerd , Koen L I van Gassen , Dalal AlBogami , Kishwer Kumar , Ali Syed Muhammad Akhtar , Hiba Binomar , Fowzan S Alkuraya

Journal: GENETICS IN MEDICINE

PubMed ID: 39132680

Doi: 10.1016/j.gim.2024.101231

Products & Services: Peptide Synthesis

Reversibly photoswitchable protein assemblies with collagen affinity for in vivo photoacoustic imaging of tumors

Authors: Shuai Chen , Kaixin Li , Xin Chen , Shan Lei , Jing Lin , Peng Huang

Journal: Science Advances

PubMed ID: 39213344

Doi: 10.1126/sciadv.adn8274

Products & Services: Codon Optimization

Enzyme-Dynamic Extracellular Vesicles for Metalloimmunotherapy of Malignant Pleural Effusions

Authors: Jiexin Li , Ruiqi Yang , Fuqiang Dong , Qian Qiu , Zhen Jiang , He Ren , Chen Zhang , Gengqi Liu , Jonathan F Lovell , Yumiao Zhang

Journal: ACS Nano

PubMed ID: 39109520

Doi: 10.1021/acsnano.3c12375

Products & Services: Recombinant Proteins

A broadly cross-reactive i-body to AMA1 potently inhibits blood and liver stages of Plasmodium parasites

Authors: Dimuthu Angage, Jill Chmielewski, Janesha C Maddumage, Eva Hesping, Sabrina Caiazzo, Keng Heng Lai, Lee Ming Yeoh, Joseph Menassa, D Herbert Opi, Callum Cairns, Hamsa Puthalakath, James G Beeson, Marc Kvansakul, Justin A Boddey, Danny W Wilson, Robin F Anders, Michael Foley

Journal: Nat Commun

PubMed ID: 39174515

Doi: 10.1038/s41467-024-50770-7

Products & Services: Gene Synthesis

Confined Gel-Electromembrane Extraction of Oligonucleotides

Authors: Cong Liu, Jie Liu, Quan Liu, Qianyun Zhu, Hao Wang, Xiangming Fang, Wenfang Zhang, Zilong Liu, Chuixiu Huang

Journal: ANALYTICAL CHEMISTRY

PubMed ID: 39078883

Doi: 10.1021/acs.analchem.4c02239

Products & Services: Custom DNA/RNA Oligos

Mechanism of heterochromatin remodeling revealed by the DDM1 bound nucleosome structures

Authors: Hongwei Zhang , Zhanxi Gu , Yuan Zeng , Yu Zhang

Journal: Structure

PubMed ID: 38870940

Doi: 10.1016/j.str.2024.05.013

Products & Services: Proteins, Expression, Isolation and Analysis

OPALIN is an LGI1 receptor promoting oligodendrocyte differentiation

Authors: Xiao-Yu Teng , Ping Hu , Cai-Ming Zhang , Qin-Xin Zhang , Guolin Yang , Yan-Yu Zang , Zhi-Xiong Liu , Guiquan Chen , Yun Stone Shi

Journal: Proceedings of the National Academy of Sciences of the United States of America

PubMed ID: 39083419

Doi: 10.1073/pnas.2403652121

Products & Services: Catalog Antibody

A Minimalist Pathogen-Like Sugar Nanovaccine for Enhanced Cancer Immunotherapy

Authors: Yu Miao , Le Niu , Xinying Lv , Qiang Zhang , Zhisheng Xiao , Zhaoxin Ji , Linfu Chen , Yi Liu , Nanhui Liu , Junjie Zhu , Yang Yang , Qian Chen

Journal: ADVANCED MATERIALS

PubMed ID: 39210649

Doi: 10.1002/adma.202410715

Products & Services: Peptide Synthesis

Peptide degrader-based targeting of METTL3/14 improves immunotherapy response in cutaneous melanoma

Authors: Hong Han , Zenghui Li , Yuqing Feng , He Song , Zhixiong Fang , Dingxiao Zhang , Dan Yuan , Junfeng Shi

Journal: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PubMed ID: 39136347

Doi: doi.org/10.1002/anie.202407381

Products & Services: Recombinant Proteins

The Effects of the Carrier and Ligand Spatial Conformation on RNA Nanodrug Cell Delivery

Authors: Zhuang Zhang , Siying Li , Hongda Wang , Yuping Shan

Journal: Analytical Chemistry

PubMed ID: 39096242

Doi: 10.1021/acs.analchem.4c02270

Products & Services: Peptide Synthesis

Reversible control of kinase signaling through chemical-induced dephosphorylation

Authors: Ying Sun , Rihong Zhou , Jin Hu , Shan Feng , Qi Hu

Journal: Communications Biology

PubMed ID: 39217250

Doi: 10.1038/s42003-024-06771-9

Products & Services: Proteins, Expression, Isolation and Analysis Recombinant Proteins

Identification of endothelial protein C receptor as a novel druggable agonistic target for reendothelialization promotion and thrombosis prevention of eluting stent

Authors: Jing Chen , Changyi Zhou , Weilun Fang , Jiasheng Yin , Jian Shi , Junbo Ge , Li Shen , Shi-Ming Liu , Shao-Jun Liu

Journal: Bioactive Materials

Doi: doi.org/10.1016/j.bioactmat.2024.07.028

Products & Services: Peptide Synthesis

Lytic transglycosylase Slt of Pseudomonas aeruginosa as a periplasmic hub protein

Authors: Luis F Avila-Cobian, Stefania De Benedetti, Hidekazu Hoshino, Van T Nguyen, Amr M El-Araby, Safaa Sader, Daniel D Hu, Sara L Cole, Choon Kim, Jed F Fisher, Matthew M Champion, Shahriar Mobashery

Journal: Protein Sci

PubMed ID: 38864725

Doi: 10.1002/pro.5038

Products & Services: Molecular Biology Reagents

The strongest protein binder is surprisingly labile

Authors: Alba Fernandez-Calvo, Antonio Reifs, Laura Saa, Aitziber L Cortajarena, David De Sancho, Raul Perez-Jimenez

Journal: Protein Sci

PubMed ID: 38864696

Doi: 10.1002/pro.5030

Products & Services: Molecular Biology Reagents

Fluorinated Titanium Oxide (TiO2-xFx) Nanospindles as Ultrasound-Triggered Pyroptosis Inducers to Boost Sonodynamic Immunotherapy

Authors: Shumin Sun , Xuan Huang , Nailin Yang , Huali Lei , Zifan Pei , Zhihui Han , Lin Liu , Fei Gong , Qiao Yu , Jingrui Li , Youdong Chen , Liang Cheng

Journal: ACS Nano

PubMed ID: 39010657

Doi: 10.1021/acsnano.4c05448

Products & Services: Proteins, Expression, Isolation and Analysis

Tissue-based T cell activation and viral RNA persist for up to 2 years after SARS-CoV-2 infection

Authors: Michael J Peluso, Dylan Ryder, Robert R Flavell, Yingbing Wang, Jelena Levi, Brian H LaFranchi, Tyler-Marie Deveau, Amanda M Buck, Sadie E Munter, Kofi A Asare, Maya Aslam, Walter Koch, Gyula Szabo, Rebecca Hoh, Monika Deswal, Antonio E Rodriguez, Melissa Buitrago, Viva Tai, Uttam Shrestha, Scott Lu, Sarah A Goldberg, Thomas Dalhuisen, Joshua J Vasquez, Matthew S Durstenfeld, Priscilla Y Hsue, J Daniel Kelly, Nitasha Kumar, Jeffrey N Martin, Aruna Gambhir, Ma Somsouk, Youngho Seo, Steven G Deeks, Zoltan G Laszik, Henry F VanBrocklin, Timothy J Henrich

Journal: Sci Transl Med

PubMed ID: 38959327

Doi: 10.1126/scitranslmed.adk3295

Products & Services: Molecular Biology Reagents

Fit-for-purpose heterodivalent single-domain antibody for gastrointestinal targeting of toxin B from Clostridium difficile

Authors: Everardo R Rodriguez Rodriguez, Rune Thorbjørn Nordvang, Marcus Petersson, Jakob Kræmmer Haar Rendsvig, Emma Wenzel Arendrup, Monica L Fernández Quintero, Timothy P Jenkins, Andreas H Laustsen, Sandra Wingaard Thrane

Journal: Protein Sci

PubMed ID: 38923049

Doi: 10.1002/pro.5035

Products & Services: Proteins, Expression, Isolation and Analysis

Engineering psychrophilic polymerase for nanopore long-read sequencing

Authors: Yaping Sun , Danny Hsu Ko , Jie Gao , Kang Fu , Yuanchen Mao , Yun He , Hui Tian

Journal: Front Bioeng Biotechnol

PubMed ID: 39011153

Doi: 10.3389/fbioe.2024.1406722

Products & Services: PCR Cloning and Subcloning

Force-regulated chaperone activity of BiP/ERdj3 is opposite to their homologs DnaK/DnaJ

Authors: Souradeep Banerjee, Debojyoti Chowdhury, Soham Chakraborty, Shubhasis Haldar

Journal: Protein Sci

PubMed ID: 38864739

Doi: 10.1002/pro.5068

Products & Services: Molecular Biology Reagents

Improvement and application of vacuum-infiltration system in tomato

Authors: Xinghao Yao, Ayat Taheri, Hang Liu, Yaojie Zhang, Ling Li, Jin Shao, Ke Wu, Qing Miao, Weizhi He, Xinyi Hu, Kexuan Tang

Journal: Horticulture research

Doi: doi.org/10.1093/hr/uhae197

Products & Services: Plasmid DNA Preparation

Structural insight into the Csx1-Crn2 fusion self-limiting ribonuclease of type III CRISPR system

Authors: Danping Zhang 1, Liyang Du 1, Haishan Gao 2 3, Cai Yuan 4, Zhonghui Lin 1

Journal: Nucleic Acids Res

PubMed ID: 38967023

Doi: 10.1093/nar/gkae569

Products & Services: Gene Synthesis

The adaptor protein ECAP, the corepressor LEUNIG, and the transcription factor BEH3 interact and regulate microsporocyte generation in Arabidopsis

Authors: Lei Shi, Changjiang Li, Gaofeng Lv, Xing Li, Wutao Feng, Yujing Bi, Wenhui Wang, Youqun Wang, Lei Zhu, Wenqiang Tang, Ying Fu

Journal: Plant Cell

PubMed ID: 38526222

Doi: 10.1093/plcell/koae086

Products & Services: Gene Synthesis

Evaluation of combination vaccines targeting transmission of Plasmodium falciparum and P. vivax

Authors: Yi Cao 1, Clifford T H Hayashi , Maisa da Silva Araujo , Abhai K Tripathi , Alice Oliveira Andrade , Jansen Fernandes Medeiros , Joseph Vinetz & Nirbhay Kumar

Journal: Vaccine

PubMed ID: 39033079

Doi: 10.1016/j.vaccine.2024.07.041

Products & Services: Codon Optimization

Cytochrome b5 diversity in green lineages preceded the evolution of syringyl lignin biosynthesis

Authors: Xianhai Zhao, Yunjun Zhao, Qing-Yin Zeng, Chang-Jun Liu

Journal: Plant Cell

PubMed ID: 38657101

Doi: 10.1093/plcell/koae120

Products & Services: Gene Synthesis

Amplification editing enables efficient and precise duplication of DNA from short sequence to megabase and chromosomal scale

Authors: Ruiwen Zhang , Zhou He , Yajing Shi , Xiangkun Sun , Xinyu Chen , Guoquan Wang , Yizhou Zhang , Pan Gao , Ying Wu , Shuhan Lu , Junyi Duan , Shangwu Sun , Na Yang , Wei Fan , Kaitao Zhao , Bei Yang , Yuchen Xia , Yan Zhang , Ying Zhang , Hao Yin

Journal: Cell

PubMed ID: 38936359

Doi: 10.1016/j.cell.2024.05.056

Products & Services: Custom RNAi Services

Optimizing the Design and Geometry of T Cell-Engaging Bispecific Antibodies Targeting CEA in Colorectal Cancer

Authors: Abdullah Elsayed, Louis Plüss, Larissa Nideroest, Giulia Rotta, Marina Thoma, Nathan Zangger, Frederik Peissert, Stefanie K Pfister, Christian Pellegrino, Sheila Dakhel Plaza, Roberto De Luca, Markus G Manz, Annette Oxenius, Emanuele Puca, Cornelia Halin, Dario Neri

Journal: Mol Cancer Ther

PubMed ID: 38638035

Doi: 10.1158/1535-7163.MCT-23-0766

Products & Services: Gene Synthesis

Mechanisms Ensuring Fidelity of Family X DNA Polymerases in Programmed DNA rearrangements in Paramecium tetraurelia

Authors: Antonin Nourisson, Sophia Missoury, Ahmed Haouz, Marc Delarue

Journal: biorxiv

Doi: 2024.07.26.605286

Products & Services: Gene Synthesis

Impact of Equilibrative Nucleoside Transporters TgAT1, TgENT1, and TgENT3 on Toxoplasma gondii Infection and Differentiation

Authors: Amber Goerner, Gabriel Messina, Lea Drogalis Beckham, Bruno Martorelli Di Genova

Journal: biorxiv

Doi: doi.org/10.1101/2024.07.10.601519

Products & Services: Gene Synthesis

Regulatory Peptide Encoded by the Primary Transcript of miR396a Influences Gene Expression and Root Development in Solanum lycopersicum

Authors: Zhengjie Wang, Ruili Lv, Chenglin Su, Yan Li, Sizhe Fang, Ruirui Yang, Jiaxuan Zhu, Ruiming Wang, Jun Meng, Yushi Luan

Journal: J Agric Food Chem

PubMed ID: 38994823

Doi: 10.1021/acs.jafc.4c03588

Products & Services: Peptide Synthesis

Comparative biochemistry of PET hydrolase-carbohydrate-binding module fusion enzymes on a variety of PET substrates

Authors: Andrew Philip Rennison , Andreas Prestel , Peter Westh , Marie Sofie Møller

Journal: Enzyme and Microbial Technology

PubMed ID: 39047349

Doi: 10.1016/j.enzmictec.2024.110479

Products & Services: Gene Synthesis Mutagenesis Services

Mechanism of ceramide synthase inhibition by fumonisin B1

Authors: Zike Zhang 1 2 4, Qi Fang 1 2 4, Tian Xie 1 2, Xin Gong

Journal: Structure

Doi: 10.1016/j.str.2024.06.002

Products & Services: Proteins, Expression, Isolation and Analysis

Discovery of antimicrobial peptides clostrisin and cellulosin from Clostridium: insights into their structures, co-localized biosynthetic gene clusters, and antibiotic activity

Authors: Moisés Alejandro Alejo Hernandez , Katia Pamela Villavicencio Sánchez , Rosendo Sánchez Morales , Karla Georgina Hernández-Magro Gil, David Silverio Moreno-Gutiérrez , Eddie Guillermo Sanchez-Rueda , Yanet Teresa-Cruz , Brian Choi, Armando Hernández Garcia , Alba Romero-Rodríguez, Oscar Juárez , Siseth Martínez-Caballero , Mario Figueroa , Corina-Diana Ceapă

Journal: Beilstein Journal of Organic Chemistry

PubMed ID: 39109298

Doi: 10.3762/bjoc.20.159

Products & Services: Gene Synthesis

Acceptors stability modulates the efficiency of post-translational protein N-glycosylation

Authors: Paula M Couto, Carlos M A Guardia, Facundo L Couto, Carlos A Labriola, María S Labanda, Julio J Caramelo

Journal: FASEB J

PubMed ID: 38934375

Doi: 10.1096/fj.202302267R

Products & Services: Proteins, Expression, Isolation and Analysis Gene Synthesis

Integration of validated functional evidence to support the pathogenicity of KCNH2 variants

Authors: Reema W Aljassar, Qianyi Shen, Buthaina Albash, Jamie I Vandenberg, Mohammad A Ebrahim, Chai-Ann Ng

Journal: Genet Med Open

PubMed ID: 39669639

Doi: 10.1016/j.gimo.2024.101868

Products & Services: Gene Synthesis

Activated Clec4n Neutrophils Aggravate Lung Injury in an Endothelial IGFBP7-Dependent Manner

Authors: Lin-Chao Yu, Rui He, Dao-Xin Wang, Di Qi

Journal: Am J Respir Cell Mol Biol

PubMed ID: 38574235

Doi: 10.1165/rcmb.2024-0017OC

Products & Services: Molecular Biology Reagents

METTL14 contributes to the progression of nasopharyngeal carcinoma through regulating the stability of AOC1 mRNA

Authors: Changan Hu, Shengguan Song, Shanglong Zhao, Zhen Xue, Xiwen Zhu

Journal: Hereditas

PubMed ID: 38956710

Doi: 10.1186/s41065-024-00317-z

Products & Services: Mutant Libraries

Rbfox1 controls alternative splicing of focal adhesion genes in cardiac muscle cells

Authors: Peter Zorn, Jaime Calvo Sánchez, Tala Alakhras, Barbara Schreier, Michael Gekle, Stefan Hüttelmaier, Marcel Köhn

Journal: J Mol Cell Biol

PubMed ID: 38253401

Doi: 10.1093/jmcb/mjae003

Products & Services: Mutant Libraries

Screening L-Lysine-Overproducing Escherichia coli Using Artificial Rare Codons and a Rare Codon-Rich Marker

Authors: Shen Li , Tianhao Xu , Xinru Meng , Yujuan Yan , Ying Zhou , Lei Duan , Yulong Tang , Li Zhu & Litao Sun

Journal: Nucleic Acids Research

PubMed ID: 38989624

Doi: doi.org/10.3390/

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DNA-terminus-dependent transcription by T7 RNA polymerase and its C-helix mutants

Authors: Bingbing Yu , Yifan Chen , Yan Yan , Xueling Lu , Bin Zhu

Journal: Nucleic Acids Res

PubMed ID: 38979568

Doi: 10.1093/nar/gkae593

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Realveolarization with inhalable mucus-penetrating lipid nanoparticles for the treatment of pulmonary fibrosis in mice

Authors: Yan Wang , Jing Zhang , Ying Liu , Xiao Yue , Kun Han , Zhichao Kong , Yuanmin Dong , Zhenmei Yang , Zhipeng Fu , Chunwei Tang , Chongdeng Shi , Xiaotian Zhao , Maosen Han , Zhibin Wang , Yulin Zhang , Chen Chen , Anning Li , Peng Sun , Danqing Zhu , Kun Zhao , Xinyi Jiang

Journal: Sci Adv

PubMed ID: 38865465

Doi: 10.1126/sciadv.ado4791

Organ-Specific Gene Expression Control Using DNA Origami-Based Nanodevices

Authors: Yuxiang Liu, Ruixuan Wang, Qimingxing Chen, Yan Chang, Qi Chen, Kodai Fukumoto, Bingxun Wang, Jianchen Yu, Changfeng Luo, Jiayuan Ma, Xiaoxia Chen, Yuko Murayama, Kenichi Umeda, Noriyuki Kodera, Yoshie Harada, Shun-Ichi Sekine, Jianfeng Li, Hisashi Tadakuma

Journal: NANO LETTERS

PubMed ID: 38920331

Doi: 10.1021/acs.nanolett.4c02104

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A C-Degron Structure-Based Approach for the Development of Ligands Targeting the E3 Ligase TRIM7

Authors: Christian J Muñoz Sosa , Christopher Lenz , Anton Hamann , Frederic Farges , Johannes Dopfer , Andreas Krämer , Veronika Cherkashyna , Andrey Tarnovskiy , Yurii S Moroz , Ewgenij Proschak , Václav Němec , Susanne Müller , Krishna Saxena , Stefan Knapp

Journal: ACS Chem Biol

PubMed ID: 38934237

Doi: 10.1021/acschembio.4c00301

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Nanopore Identification of L‐, D‐Lactic Acids, D‐Glucose and Gluconic Acid in the Serum of Human and Animals

Authors: Wendong Jia, Yusheng Ouyang, Shanyu Zhang, Panke Zhang, Shuo Huang

Journal: Small Methods

PubMed ID: 38864527

Doi: 10.1002/smtd.202400664

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