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Plasmodium vivax serological exposure markers: PvMSP1-42-induced humoral and memory B-cell response generates long-lived antibodies

Authors: Feng Lu, Jiahui Xu, Yaobao Liu, Zhenyu Ren, Junhu Chen, Weijuan Gong, Yi Yin, Yinyue Li, Li Qian, Xinlong He, Xiu Han, Zhijie Lin, Jingyuan Lu, Wenwen Zhang, Jiali Liu, Didier Menard, Eun-Taek Han, Jun Cao

Journal: PLoS Pathog

PubMed ID: 38941356

Doi: 10.1371/journal.ppat.1012334

Products & Services: Proteins, Expression, Isolation and Analysis

IMT030122, A novel engineered EpCAM/CD3/4-1BB tri-specific antibody, enhances T-cell recruitment and demonstrates anti-tumor activity in mouse models of colorectal cancer

Authors: Jianbo Shen, Niliang Qian, Guili Xu, Xiaoqian Dou, Ying An, Cuima Yang, Yujie Liu, Yunhui Liu, Xiujie Pan, Jingjing Wang, Guijun Bai, Hao Chen, Xiaolin Zhu, Xin Gao, Guoxiong Zhou, Qinzhi Xu

Journal: Int Immunopharmacol

PubMed ID: 38878486

Doi: 10.1016/j.intimp.2024.112424

Products & Services: Proteins, Expression, Isolation and Analysis

Monoterpene-chalcone conjugates and diarylheptanoids isolated from the seeds of Alpinia katsumadai Hayata with cytotoxic activity

Authors: Hua-Lin You, Bo Zhou, Meng-Jia Guo, Xin-Man Zhao, Xiao-Long Li, Xiang-Chun Shen, Nen-Ling Zhang

Journal: Phytochemistry

PubMed ID: 38945281

Doi: 10.1016/j.phytochem.2024.114197

Products & Services: PCR Cloning and Subcloning

Single missense mutations in Vi capsule synthesis genes confer hypervirulence to Salmonella Typhi

Authors: Gi Young Lee, Jeongmin Song

Journal: Nat Commun

PubMed ID: 38898034

Doi: 10.1038/s41467-024-49590-6

Products & Services: Recombinant Proteins

A 14-amino acid cationic peptide Bolespleenin from the marine fish mudskipper Boleophthalmus pectinirostris exhibiting potent antimicrobial activity and therapeutic potential

Authors: Yuqi Bai, Weibin Zhang, Wenbin Zheng, Xin-Zhan Meng, Yingyi Duan, Chang Zhang, Fangyi Chen, Ke-Jian Wang

Journal: Biochem Pharmacol

PubMed ID: 38852647

Doi: 10.1016/j.bcp.2024.116344

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The role of MASP1 in the complement system and expression characteristics in response to GCRV infection in grass carp

Authors: Yuling Wei, Zhao Lv, Tiaoyi Xiao, Zongjun Du

Journal: Fish Shellfish Immunol

PubMed ID: 38901682

Doi: 10.1016/j.fsi.2024.109712

Products & Services: Proteins, Expression, Isolation and Analysis

Adeno-associated viral delivery of Env-specific antibodies prevents SIV rebound after discontinuing antiretroviral therapy

Authors: Vadim A Klenchin, Natasha M Clark, Nida K Keles, Saverio Capuano, Rosemarie Mason, Guangping Gao, Aimee Broman, Emek Kose, Taina T Immonen, Christine M Fennessey, Brandon F Keele, Jeffrey D Lifson, Mario Roederer, Matthew R Gardner, David T Evans

Journal: biorxiv

PubMed ID: 38895320

Doi: 10.1101/2024.05.30.593694

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Farnesyltransferase inhibitor lonafarnib suppresses respiratory syncytial virus infection by blocking conformational change of fusion glycoprotein

Authors: Qi Yang, Bao Xue, Fengjiang Liu, Yongzhi Lu, Jielin Tang, Mengrong Yan, Qiong Wu, Ruyi Chen, Anqi Zhou, Lijie Liu, Junjun Liu, Changbin Qu, Qingxin Wu, Muqing Fu, Jiayi Zhong, Jianwei Dong, Sijie Chen, Fan Wang, Yuan Zhou, Jie Zheng, Wei Peng, Jinsai Shang, Xinwen Chen

Journal: Signal Transduct Target Ther

PubMed ID: 38853183

Doi: 10.1038/s41392-024-01858-5

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Microglia undergo sex-dimorphic transcriptional and metabolic rewiring during aging

Authors: Seokjo Kang, Emily Y Ko, Amelia E Andrews, Juliana E Shin, Karina J Nance, Pijus K Barman, Peter S Heeger, Willard M Freeman, Bérénice A Benayoun, Helen S Goodridge

Journal: J Neuroinflammation

PubMed ID: 38840206

Doi: 10.1186/s12974-024-03130-7

Products & Services: Proteins, Expression, Isolation and Analysis

Library-Assisted Evolution in Eukaryotic Cells Yield Adenine Base Editors with Enhanced Editing Specificity

Authors: Shenlin Hsiao, Shuanghong Chen, Yanhong Jiang, Qiudao Wang, Yang Yang, Yongrong Lai, Tao Zhong, Jiaoyang Liao, Yuxuan Wu

Journal: Adv Sci (Weinh)

PubMed ID: 38874509

Doi: 10.1002/advs.202309004

Products & Services: Molecular Biology Reagents

Discovery of RXFP2 genetic association in resistant hypertensive men and RXFP2 antagonists for the treatment of resistant hypertension

Authors: Shan-Shan Zhang, Lance Larrabee, Andrew H Chang, Sapna Desai, Lisa Sloan, Xin Wang, Yixuan Wu, Nazia Parvez, Karen Amaratunga, Allison C Hartman, Abby Whitnall, Joseph Mason, Nicholas P Barton, Audrey Y Chu, Jonathan M Davitte, Adam J Csakai, Caitlin Vestal Tibbetts, Audrey E Tolbert, Heather O'Keefe, Jessie Polanco, Joseph Foley, Casey Kmett, Jonathan Kehler, Gabriela Kozejova, Feng Wang, Andrew P Mayer, Patrick Koenig, Davide Foletti, Steven J Pitts, Christine G Schnackenberg

Journal: Sci Rep

PubMed ID: 38851835

Doi: 10.1038/s41598-024-62804-7

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A phage nucleus-associated protein from the jumbophage Churi inhibits bacterial growth through protein translation interference

Authors: Wichanan Wannasrichan, Sucheewin Krobthong, Chase J Morgan, Emily G Armbruster, Milan Gerovac, Yodying Yingchutrakul, Patompon Wongtrakoongate, Jörg Vogel, Chanat Aonbangkhen, Poochit Nonejuie, Joe Pogliano, Vorrapon Chaikeeratisak

Journal: biorxiv

PubMed ID: 38915640

Doi: 10.1101/2024.06.15.599175

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The pigeon circovirus evolution, epidemiology and interaction with the host immune system under One Loft Race rearing conditions

Authors: Tomasz Stenzel, Daria Dziewulska, Ewa Łukaszuk, Joy M Custer, Matthew D De Koch, Simona Kraberger, Arvind Varsani

Journal: Sci Rep

PubMed ID: 38877168

Doi: 10.1038/s41598-024-64587-3

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Cleaved TMEM106B forms amyloid aggregates in central and peripheral nervous systems

Authors: Mehtap Bacioglu, Manuel Schweighauser, Derrick Gray, Sofia Lövestam, Taxiarchis Katsinelos, Annelies Quaegebeur, John van Swieten, Zane Jaunmuktane, Stephen W. Davies, Sjors H. W. Scheres, Michel Goedert, Bernardino Ghetti, and Maria Grazia Spillantini

Journal: Acta Neuropathologica

PubMed ID: 38886865

Doi: 10.1186/s40478-024-01813-z

Products & Services: Proteins, Expression, Isolation and Analysis

A new anti-CRISPR gene promotes the spread of drug-resistance plasmids in Klebsiella pneumoniae

Authors: Chunyu Jiang, Chengzhi Yu, Shuyi Sun, Jiajia Lin, Mufeng Cai, Zhenquan Wei, Lingling Feng, Jianhui Li, Yan Zhang, Ke Dong ... Show moreAuthor Notes

Journal: Nucleic Acids Res

PubMed ID: 38888121

Doi: 10.1093/nar/gkae516

Products & Services: Proteins, Expression, Isolation and Analysis

Structural basis for an early stage of the photosystem II repair cycle in Chlamydomonas reinhardtii

Authors: Anjie Li, Tingting You, Xiaojie Pang, Yidi Wang, Lijin Tian, Xiaobo Li & Zhenfeng Liu

Journal: Nature Communications

PubMed ID: 38890314

Doi: 10.1038/s41467-024-49532-2

Products & Services: CRISPR RNAs/Cas9 Proteins(INACTIVE)

Improved protein splicing through viral passaging

Authors: Adam J Hume , Dylan J Deeney , John S Smetana , Jacquelyn Turcinovic , John H Connor , Marlene Belfort , Elke Mühlberger , Christopher W Lennon

Journal: MBio

PubMed ID: 38780266

Doi: 10.1128/mbio.00984-24

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Heterologous booster vaccination enhances antibody responses to SARS-CoV-2 by improving Tfh function and increasing B-cell clonotype SHM frequency

Authors: Yanli Song, Jiaolei Wang, Zhihui Yang, Changgui Li

Journal: Frontiers in Immunology

Doi: 10.3389/fimmu.2024.1406138

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Tight Junction Component Occludin Binds to FIP5 to Regulate Endosome Trafficking and Mitotic Spindle Function

Authors: Zichao Zhang , Jing Chen , Rongze Ma , Chongshen Xu , Yunzhe Lu , Jiecan Zhou , Kun Xia , Pengfei Lu

Journal: Adv Sci (Weinh)

PubMed ID: 38884279

Doi: 10.1002/advs.202308822

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A bispecific antibody exhibits broad neutralization against SARS-CoV-2 Omicron variants XBB.1.16, BQ.1.1 and sarbecoviruses

Authors: Yingdan Wang # 1 2, Aihua Hao # 1, Ping Ji # 1, Yunping Ma # 1 3, Zhaoyong Zhang # 4, Jiali Chen 1, Qiyu Mao 1, Xinyi Xiong 4, Palizhati Rehati 1, Yajie Wang 1, Yanqun Wang 4, Yumei Wen 1, Lu Lu 1, Zhenguo Chen 1, Jincun Zhao 5 6, Fan Wu 7, Jinghe Huang 8 9, Lei Sun 10

Journal: Nat Commun

PubMed ID: 38879565

Doi: 10.1038/s41467-024-49096-1

Products & Services: Gene Synthesis

The binding mechanism of an anti-multiple myeloma antibody to the human GPRC5D homodimer

Authors: Pengfei Yan , Xi Lin , Lijie Wu , Lu Xu , Fei Li , Junlin Liu , Fei Xu

Journal: Nat Commun

PubMed ID: 38898050

Doi: 10.1038/s41467-024-49625-y

Products & Services: Gene Synthesis

Molecular recognition of the atypical chemokine-like peptide GPR15L by its cognate receptor GPR15

Authors: Zhongyuan Zhang , You Zheng , Lu Xu , Yang Yue , Kexin Xu , Fei Li 1, Fei Xu

Journal: Cell Discov

PubMed ID: 38918398

Doi: 10.1038/s41421-024-00698-5

Products & Services: Peptide Synthesis

Enhancing precision targeting of ovarian cancer tumor cells in vivo through extracellular vesicle engineering

Authors: Mona Alharbi, Andrew Lai, Nihar Godbole, Dominic Guanzon, Soumyalekshmi Nair, Felipe Zuñiga, Alexander Quinn, Mengliu Yang, Sherry Y Wu, Carlos Salomon

Journal: Int J Cancer

PubMed ID: 38848494

Doi: 10.1002/ijc.35055

Products & Services: Molecular Biology Reagents

Electrophysiological Impact of SARS-CoV-2 Envelope Protein in U251 Human Glioblastoma Cells: Possible Implications in Gliomagenesis?

Authors: Lorenzo Monarca, Francesco Ragonese, Andrea Biagini, Paola Sabbatini, Matteo Pacini, Alessandro Zucchi, Roberta Spaccapelo, Paola Ferrari, Andrea Nicolini, Bernard Fioretti

Journal: Int J Mol Sci

PubMed ID: 38928376

Doi: 10.3390/ijms25126669

Products & Services: Gene Synthesis

Baculovirus surface display of a chimeric E-NS1 protein of YFV protects against YFV infection

Authors: Carla Tomatis, María Florencia Ferrer, Silvia Aquila, Pablo Daniel Thomas, Paula Nazarena Arrías, Leticia Ferrelli, Matías Pidre, Victor Romanowski, Eugenio Antonio Carrera Silva, Ricardo Martín Gómez

Journal: Vaccine

PubMed ID: 38852036

Doi: 10.1016/j.vaccine.2024.06.013

Products & Services: Immunoassay Development Services

miR-520e and its promoter region DNA methylation as potential biomarkers in atherosclerosis

Authors: Mimi Mu, Gao Liu, Xiaoyu Ding, Lijun Xue, Dandan Li, Yunhua Zhu, Nan Zhang, Jia Wu, Junjun Wang

Journal: Biochem Cell Biol

PubMed ID: 38917487

Doi: 10.1139/bcb-2023-0326

Products & Services: Molecular Biology Reagents

Scaffold-enabled high-resolution cryo-EM structure determination of RNA

Authors: Daniel B Haack, Boris Rudolfs, Shouhong Jin, Kevin M Weeks, Navtej Toor

Journal: biorxiv

PubMed ID: 38915706

Doi: 10.1101/2024.06.10.598011

Products & Services: Molecular Biology Reagents

Synthetic Peptides Elicit Humoral Response against Porcine Reproductive and Respiratory Syndrome Virus in Swine

Authors: Francisco Perez-Duran, Fernando Calderon-Rico, Luis Enrique Franco-Correa, Alicia Gabriela Zamora-Aviles, Roberto Ortega-Flores, Daniel Durand-Herrera, Alejandro Bravo-Patiño, Ricarda Cortes-Vieyra, Ilane Hernandez-Morales, Rosa Elvira Nuñez-Anita

Journal: Vaccines (Basel)

PubMed ID: 38932381

Doi: 10.3390/vaccines12060652

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mRNA Vaccine for Alzheimer's Disease: Pilot Study

Authors: Armine Hovakimyan, Garri Chilingaryan, Olga King, Joia Kai Capocchi, Jean Paul Chadarevian, Hayk Davtyan, Roman Kniazev, Michael G Agadjanyan, Anahit Ghochikyan

Journal: Vaccines (Basel)

PubMed ID: 38932388

Doi: 10.3390/vaccines12060659

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Androgen-responsive FOXP4 is a target for endometrial carcinoma

Authors: Kayo Kayahashi, Mahadi Hasan, Anowara Khatun, Susumu Kohno, Jumpei Terakawa, Shin-Ichi Horike, Natsumi Toyoda, Ayumi Matsuoka, Takashi Iizuka, Takeshi Obata, Masanori Ono, Yasunari Mizumoto, Chiaki Takahashi, Hiroshi Fujiwara, Takiko Daikoku

Journal: Commun Biol

PubMed ID: 38890503

Doi: 10.1038/s42003-024-06433-w

Products & Services: Molecular Biology Reagents

Development of GPC3-CAR-NK cells and optimization as a therapy for HCC

Authors: Bihui Cao, Qianqian Ni, Zhuxin Chen, Shuo Yang, Xinkui Zhang, Haotao Su, Zhenfeng Zhang, Qi Zhao, Xiaolan Zhu, Manting Liu

Journal: J Leukoc Biol

PubMed ID: 38922297

Doi: 10.1093/jleuko/qiae144

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Selenium nanoparticles enhance mucosal immunity against Mycobacterium bovis infection

Authors: Xin Ge, Zhengmin Liang, Kui Li, Yuhui Dong, Yuanzhi Wang, Yiduo Liu, ZiYi Liu, Haoran Wang, Yue Nan, SiYan Chen, Lin Li, Yanbin Guo, Xiangmei Zhou

Journal: Int Immunopharmacol

PubMed ID: 38878484

Doi: 10.1016/j.intimp.2024.112384

Products & Services: Molecular Biology Reagents

PAM-flexible Engineered FnCas9 variants for robust and ultra-precise genome editing and diagnostics

Authors: Sundaram Acharya, Asgar Hussain Ansari, Prosad Kumar Das, Seiichi Hirano, Meghali Aich, Riya Rauthan, Sudipta Mahato, Savitri Maddileti, Sajal Sarkar, Manoj Kumar, Rhythm Phutela, Sneha Gulati, Abdul Rahman, Arushi Goel, C Afzal, Deepanjan Paul, Trupti Agrawal, Vinay Kumar Pulimamidi, Subhadra Jalali, Hiroshi Nishimasu, Indumathi Mariappan, Osamu Nureki, Souvik Maiti, Debojyoti Chakraborty

Journal: Nat Commun

PubMed ID: 38942756

Doi: 10.1038/s41467-024-49233-w

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Experimental inoculation of pigs with monkeypox virus results in productive infection and transmission to sentinels

Authors: Emily Mantlo, Jessie D Trujillo, Natasha N Gaudreault, Igor Morozov, Charles E Lewis, Franco Matias-Ferreyra, Chester McDowell, Dashzeveg Bold, Taeyong Kwon, Konner Cool, Velmurugan Balaraman, Daniel Madden, Bianca Artiaga, Jayme Souza-Neto, Jeffrey B Doty, Mariano Carossino, Udeni Balasuriya, William C Wilson, Nikolaus Osterrieder, Lisa Hensley, Juergen A Richt

Journal: Emerg Microbes Infect

PubMed ID: 38712637

Doi: 10.1080/22221751.2024.2352434

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Effect of TIMPs and Their Minimally Engineered Variants in Blocking Invasion and Migration of Brain Cancer Cells

Authors: Elham Taheri, Maryam Raeeszadeh-Sarmazdeh

Journal: biorxiv

PubMed ID: 38895489

Doi: 10.1101/2024.06.05.597644

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Arboviruses antagonize insect Toll antiviral immune signaling to facilitate the coexistence of viruses with their vectors

Authors: Dongsheng Jia, Guozhong Luo, Heran Guan, Tingting Yu, Xinyan Sun, Yu Du, Yiheng Wang, Hongyan Chen, Taiyun Wei

Journal: PLoS Pathog

PubMed ID: 38865374

Doi: 10.1371/journal.ppat.1012318

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Molecular determinants of olfactory receptor activation: Comparative analysis of Olfr205 and Olfr740 family member responses to indole

Authors: Guangyao Li, Li Wang, Fangzhou Ye, Shengju Li, Hongmeng Yu

Journal: Arch Biochem Biophys

PubMed ID: 38880319

Doi: 10.1016/j.abb.2024.110061

Products & Services: Molecular Biology Reagents

Epitope-specific antibody fragments block aggregation of AGelD187N, an aberrant peptide in gelsolin amyloidosis

Authors: Laura Leimu, Patrik Holm, Anna Gąciarz, Oskar Haavisto, Stuart Prince, Ullamari Pesonen, Tuomas Huovinen, Urpo Lamminmäki

Journal: J Biol Chem

PubMed ID: 38944121

Doi: 10.1016/j.jbc.2024.107507

Products & Services: Proteins, Expression, Isolation and Analysis

Acetylation of the yeast Hsp40 chaperone protein Ydj1 fine-tunes proteostasis and translational fidelity

Authors: Siddhi Omkar, Courtney Shrader, Joel R Hoskins, Jake T Kline, Megan M Mitchem, Luca Fornelli, Sue Wickner, Andrew W Truman

Journal: biorxiv

PubMed ID: 38915721

Doi: 10.1101/2024.06.13.598777

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Identification of a novel glycoside hydrolase family 8 xylanase from Deinococcus geothermalis and its application at low temperatures

Authors: Tingting Wang, Min Lin, Yongliang Yan, Shijie Jiang, Qilin Dai, Zhengfu Zhou, Jin Wang

Journal: Arch Microbiol

PubMed ID: 38884653

Doi: 10.1007/s00203-024-04055-8

Products & Services: Proteins, Expression, Isolation and Analysis

Transgenic Soybean for Production of Thermostable α-Amylase

Authors: Zhenyan Cao, Ye Jiang, Jiajie Li, Ting Zheng, Chaoyang Lin, Zhicheng Shen

Journal: Plants (Basel)

PubMed ID: 38891347

Doi: 10.3390/plants13111539

Products & Services: Recombinant Proteins

Prokaryotic RNA N1-Methyladenosine Erasers Maintain tRNA m1A Modification Levels in

Authors: Marcus Foo, Luke R Frietze, Behnam Enghiad, Yujie Yuan, Christopher D Katanski, Huimin Zhao, Tao Pan

Journal: ACS Chem Biol

PubMed ID: 38912606

Doi: 10.1021/acschembio.4c00278

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H3N2 canine influenza virus-like particle vaccine with great protection in beagle dogs

Authors: Fei-Fei Ge, Li-Pin Shen, De-Quan Yang, Xian-Cao Yang, Xin Li, Hai-Xiao Shen, Jian Wang, Shixin Huang

Journal: Microbiol Spectr

PubMed ID: 38874403

Doi: 10.1128/spectrum.00445-24

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Auxin resistant 2 and short hypocotyl 2 regulate cotton fiber initiation and elongation

Authors: Fei Jin, Liping Zhu, Liyong Hou, Hongbin Li, Ling Li, Guanghui Xiao

Journal: Plant Physiol

PubMed ID: 38527791

Doi: 10.1093/plphys/kiae183

Products & Services: Proteins, Expression, Isolation and Analysis

Development of Broad-Spectrum Nanobodies for the Therapy and Diagnosis of SARS-CoV-2 and Its Multiple Variants

Authors: Lei He, Qian Wu, Zhaoyong Zhang, Lingling Chen, Kuai Yu, Leibin Li, Qiong Jia, Yanqun Wang, Jianqiang Ni, Chuanbin Wang, Qi Li, Xinyan Zhai, Jincun Zhao, Yuliang Liu, Ruiwen Fan, Yi-Ping Li

Journal: Mol Pharm

PubMed ID: 38920116

Doi: 10.1021/acs.molpharmaceut.4c00165

Products & Services: Proteins, Expression, Isolation and Analysis

Interleukin-1 beta (IL-1β) as adjuvant enhances the immune effects of Aeromonas veronii inactivated vaccine in largemouth bass (Micropterus salmoides)

Authors: Ze-Sheng Zhang, Heng-Chu Ren, Xie Gu, Qian-Rong Liang, Hui Fei, Yu-Hong Yang, Shun Yang, Liang-Yin He, Li-Li Liu

Journal: Int J Biol Macromol

PubMed ID: 38876231

Doi: 10.1016/j.ijbiomac.2024.133135

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Exploring a novel GH13_5 α-amylase from Jeotgalibacillus malaysiensis D5 for raw starch hydrolysis

Authors: Nurfatini Radzlin, Mohd Shukuri Mohamad Ali, Kian Mau Goh, Amira Suriaty Yaakop, Iffah Izzati Zakaria, Ummirul Mukminin Kahar

Journal: AMB Express

PubMed ID: 38874807

Doi: 10.1186/s13568-024-01722-3

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Structural and mechanistic insights into a lysosomal membrane enzyme HGSNAT involved in Sanfilippo syndrome

Authors: Boyang Zhao, Zhongzheng Cao, Yi Zheng, Phuong Nguyen, Alisa Bowen, Robert H Edwards, Robert M Stroud, Yi Zhou, Menno Van Lookeren Campagne, Fei Li

Journal: Nat Commun

PubMed ID: 38918376

Doi: 10.1038/s41467-024-49614-1

Products & Services: PCR Cloning and Subcloning

Assessing Predictive Value of SARS-CoV-2 Epitope-Specific CD8 T-Cell Response in Patients with Severe Symptoms

Authors: Cristina Martín-Martín, Estefanía Salgado Del Riego, Jose R Vidal Castiñeira, Maria Soledad Zapico-Gonzalez, Mercedes Rodríguez-Pérez, Viviana Corte-Iglesias, Maria Laura Saiz, Paula Diaz-Bulnes, Dolores Escudero, Beatriz Suárez-Alvarez, Carlos López-Larrea

Journal: Vaccines (Basel)

PubMed ID: 38932408

Doi: 10.3390/vaccines12060679

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Functional characterization of a cystatin A from the bat Myotis davidii

Authors: Gabriel Cerqueira Alves Costa, Ricardo Jose Soares Torquato, Vinícius de Morais Gomes, Lívia Rosa-Fernandes, Giuseppe Palmisano, Aparecida Sadae Tanaka

Journal: Comp Biochem Physiol B Biochem Mol Biol

PubMed ID: 38936799

Doi: 10.1016/j.cbpb.2024.111003

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