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Development of automated microfluidic immunoassays for the detection of SARS-CoV-2 antibodies and antigen

Authors: Linwood Johnson, Maggie L Bartlett, Francisco Ramirez, Christopher D Heger, Darci R Smith

Journal: J Immunol Methods

PubMed ID: 38040191

Doi: 10.1016/j.jim.2023.113586

Products & Services: Protein and Antibody Isolation

A Novel Interaction Between RAD23A/B and Y-family DNA Polymerases

Authors: Nicholas W Ashton, Nancy Jaiswal, Natália Cestari Moreno, Irina V Semenova, Dana A D'Orlando, Marcela Teatin Latancia, Justyna McIntyre, Roger Woodgate, Irina Bezsonova

Journal: J Mol Biol

PubMed ID: 37935254

Doi: 10.1016/j.jmb.2023.168353

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Extramedullary hematopoiesis contributes to enhanced erythropoiesis during pregnancy via TGF-β signaling

Authors: Yao Fu, Zhengjuan Li, Wen Lin, Jingxin Yao, Xiang Jiang, Qun Shu, Xiaoyuan Mao, Jiaoqin Tu, Xinyuan Liang, Liping Li

Journal: Front Immunol

PubMed ID: 38045690

Doi: 10.3389/fimmu.2023.1295717

Products & Services: Molecular Biology Reagents

Insights into Molecular Diversity within the FET Family: Unraveling Phase Separation of the N-Terminal Low Complexity Domain from RNA-Binding Protein EWS

Authors: Courtney N Johnson, Kandarp A Sojitra, Erich J Sohn, Alma K Moreno-Romero, Antoine Baudin, Xiaoping Xu, Jeetain Mittal, David S Libich

Journal: biorxiv

PubMed ID: 37961424

Doi: 10.1101/2023.10.27.564484

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AR/RKIP pathway mediates the inhibitory effects of icariin on renal fibrosis and endothelial-to-mesenchymal transition in type 2 diabetic nephropathy

Authors: Wenhui Yao, Rongpin Tao, Yue Xu, Zhe-Sheng Chen, Xuansheng Ding, Lisheng Wan

Journal: J Ethnopharmacol

PubMed ID: 37977422

Doi: 10.1016/j.jep.2023.117414

Products & Services: Protein and Antibody Isolation

Changes in intestinal flora of mice induced by rEgP29 epitope peptide vaccines

Authors: Tingting Zhang, Yongxue Lv, Yinqi Zhao, Jihui Yang, Bingshuo Qian, Yazhou Zhu, Wei Zhao, Mingxing Zhu

Journal: Immun Inflamm Dis

PubMed ID: 38018604

Doi: 10.1002/iid3.1082

Products & Services: Protein and Antibody Isolation

Mutations in yeast Pcf11, a conserved protein essential for mRNA 3' end processing and transcription termination, elicit the Environmental Stress Response

Authors: Joel H Graber, Derick Hoskinson, Huiyun Liu, Katarzyna Kaczmarek Michaels, Peter S Benson, Nathaniel J Maki, Christian L Wilson, Caleb McGrath, Franco Puleo, Erika Pearson, Jason N Kuehner, Claire Moore

Journal: Genetics

PubMed ID: 37967370

Doi: 10.1093/genetics/iyad199

Products & Services: Protein and Antibody Isolation

Application of machine learning algorithms to construct and validate a prediction model for coronary heart disease risk in patients with periodontitis: a population-based study

Authors: Yicheng Wang, Binghang Ni, Yuan Xiao, Yichang Lin, Yu Jiang, Yan Zhang

Journal: Front Cardiovasc Med

PubMed ID: 38094122

Doi: 10.3389/fcvm.2023.1296405

Products & Services: Protein and Antibody Isolation

Reduction of oligomer size modulates the competition between cluster formation and phase separation of the tumor suppressor SPOP

Authors: Nafiseh Sabri, Matthew J Cuneo, Melissa R Marzahn, Jihun Lee, Jill J Bouchard, Ömer Güllülü, Sivaraja Vaithiyalingam, Madeleine B Borgia, Jeremy Schmit, Tanja Mittag

Journal: J Biol Chem

PubMed ID: 37926283

Doi: 10.1016/j.jbc.2023.105427

Products & Services: Protein and Antibody Isolation

RING-type E3 ligase BnaJUL1 ubiquitinates and degrades BnaTBCC1 to regulate drought tolerance in Brassica napus L

Authors: Jin Hu, Mudan Luo, Xianming Zhou, Zhaoyang Wang, Li Yan, Dengfeng Hong, Guangsheng Yang, Xiaohui Zhang

Journal: Plant Cell Environ

PubMed ID: 37984059

Doi: 10.1111/pce.14770

Products & Services: Protein and Antibody Isolation

SARS-CoV-2 ORF7a blocked autophagy flux by intervening in the fusion between autophagosome and lysosome to promote viral infection and pathogenesis

Authors: Shun Li, Xiaobo Li, Haowei Liang, Kuike Yu, Jingbo Zhai, Mengzhou Xue, Zhuojing Luo, Chunfu Zheng, Hao Zhang

Journal: J Med Virol

PubMed ID: 37916857

Doi: 10.1002/jmv.29200

Products & Services: Protein and Antibody Isolation

TRIM22 facilitates autophagosome-lysosome fusion by mediating the association of GABARAPs and PLEKHM1

Authors: Hansol Heo, Hyungsun Park, Myung Shin Lee, Jongyoon Kim, Juyeong Kim, Soon-Young Jung, Sun Kyeon Kim, Seongju Lee, Jaerak Chang

Journal: Autophagy

PubMed ID: 38009729

Doi: 10.1080/15548627.2023.2287925

Products & Services: Protein and Antibody Isolation

Cancer Relevance of Circulating Antibodies Against LINE-1 Antigens in Humans

Authors: Alexandra V Vylegzhanina, Ivan A Bespalov, Ksenia A Novototskaya-Vlasova, Brandon M Hall, Anatoli S Gleiberman, Han Yu, Olga V Leontieva, Katerina I Leonova, Oleg V Kurnasov, Andrei L Osterman, Grace K Dy, Alexey A Komissarov, Elena Vasilieva, Jeff Gehlhausen, Akiko Iwasaki, Christine B Ambrosone, Takemasa Tsuji, Junko Matsuzaki, Kunle Odunsi, Ekaterina L Andrianova, Andrei V Gudkov

Journal: Cancer Res Commun

PubMed ID: 37870410

Doi: 10.1158/2767-9764.CRC-23-0289

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2-Hydroxyglutarate modulates histone methylation at specific loci and alters gene expression via Rph1 inhibition

Authors: Marios Gavriil, Marco Proietto, Nicole Paczia, Aurelien Ginolhac, Rashi Halder, Elena Valceschini, Thomas Sauter, Carole L Linster, Lasse Sinkkonen

Journal: Life Sci Alliance

PubMed ID: 38011998

Doi: 10.26508/lsa.202302333

Products & Services: Codon Optimization

Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin

Authors: Qi Tang, Hassan H Fakih, Mohammad Zain Ui Abideen, Samuel R Hildebrand, Khashayar Afshari, Katherine Y Gross, Jacquelyn Sousa, Allison S Maebius, Christina Bartholdy, Pia Pernille Søgaard, Malene Jackerott, Vignesh Hariharan, Ashley Summers, Xueli Fan, Ken Okamura, Kathryn R Monopoli, David A Cooper, Dimas Echeverria, Brianna Bramato, Nicholas McHugh, Raymond C Furgal, Karen Dresser, Sarah J Winter, Annabelle Biscans, Jane Chuprin, Nazgol-Sadat Haddadi, Shany Sherman, Ümmügülsüm Yıldız-Altay, Mehdi Rashighi, Jillian M Richmond, Claire Bouix-Peter, Carine Blanchard, Adam Clauss, Julia F Alterman, Anastasia Khvorova, John E Harris

Journal: Nat Commun

PubMed ID: 37925520

Doi: 10.1038/s41467-023-42714-4

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Biochemical and cellular insights into the Baz2B protein, a non-catalytic subunit of the chromatin remodeling complex

Authors: Matthias Breindl, Dominika Spitzer, Rūta Gerasimaitė, Visvaldas Kairys, Thomas Schubert, Ramona Henfling, Uwe Schwartz, Gražvydas Lukinavičius, Laura Manelytė

Journal: Nucleic Acids Res

PubMed ID: 38000389

Doi: 10.1093/nar/gkad1096

Products & Services: Gene Synthesis

OsALB3 Is Required for Chloroplast Development by Promoting the Accumulation of Light-Harvesting Chlorophyll-Binding Proteins in Rice

Authors: Chao Zhang, Xinchen Mao, Xiaoxiao Feng, Yali Sun, Zirui Wang, Jiaqi Tang, Hengxiu Yu

Journal: Plants (Basel)

PubMed ID: 38068638

Doi: 10.3390/plants12234003

Products & Services: Molecular Biology Reagents

A dual role of RBM42 in modulating splicing and translation of CDKN1A/p21 during DNA damage response

Authors: Bella M Ben-Oz, Feras E Machour, Marian Nicola, Amir Argoetti, Galia Polyak, Rawad Hanna, Oded Kleifeld, Yael Mandel-Gutfreund, Nabieh Ayoub

Journal: Nat Commun

PubMed ID: 37993446

Doi: 10.1038/s41467-023-43495-6

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Structure and functional divergence of PIP peptide family revealed by functional studies on PIP1 and PIP2 in

Authors: Xiao-Song Yu, Hong-Run Wang, Fei-Fan Lei, Rui-Qi Li, Hui-Peng Yao, Jin-Bo Shen, Noor-Ul Ain, Yi Cai

Journal: Front Plant Sci

PubMed ID: 38078092

Doi: 10.3389/fpls.2023.1208549

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Linear motif specificity in signaling through p38α and ERK2 mitogen-activated protein kinases

Authors: Jaylissa Torres Robles, Hua Jane Lou, Guangda Shi, Pauline Lining Pan, Benjamin E Turk

Journal: Proc Natl Acad Sci U S A

PubMed ID: 37988460

Doi: 10.1073/pnas.2316599120

Products & Services: Recombinant Proteins

Ligand-based targeting of c-kit using engineered γδ T cells as a strategy for treating acute myeloid leukemia

Authors: Gianna M Branella, Jasmine Y Lee, Jennifer Okalova, Kiran K Parwani, Jordan S Alexander, Raquel F Arthuzo, Andrew Fedanov, Bing Yu, David McCarty, Harrison C Brown, Shanmuganathan Chandrakasan, Brian G Petrich, Christopher B Doering, H Trent Spencer

Journal: Front Immunol

PubMed ID: 38022523

Doi: 10.3389/fimmu.2023.1294555

Products & Services: Combinatorial Mutant library

NINJ1 is activated by cell swelling to regulate plasma membrane permeabilization during regulated necrosis

Authors: Yves Dondelinger, Dario Priem, Jon Huyghe, Tom Delanghe, Peter Vandenabeele, Mathieu J M Bertrand

Journal: Cell Death Dis

PubMed ID: 37980412

Doi: 10.1038/s41419-023-06284-z

Products & Services: Molecular Biology Reagents

Substance P Increases STAT6-Mediated Transcription Activation of Lymphocyte Cytosolic Protein 2 to Sustain M2 Macrophage Predominance in Pediatric Asthma

Authors: Miao Li, Xiao Zhong, Wenting Xu

Journal: Am J Pathol

PubMed ID: 37995836

Doi: 10.1016/j.ajpath.2023.11.003

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Expression and characterization of novel chimeric endolysin CHAPk-SH3bk against biofilm-forming methicillin-resistant Staphylococcus aureus

Authors: Manisha Behera, Gagandeep Singh, Ashutosh Vats, Mayank Roshan, Devika Gautam, Chanchal Rana, Rajesh Kumar Kesharwani, Sachinandan De, Soma M Ghorai

Journal: Int J Biol Macromol

PubMed ID: 37944719

Doi: 10.1016/j.ijbiomac.2023.127969

Products & Services: Gene Synthesis

Juvenile hormone induces reproduction via miR-1175-3p in the red imported fire ant, Solenopsis invicta

Authors: Jie Chen, Ziying Guan, Yunjie Ma, Qingxing Shi, Ting Chen, Muhammad Irfan Waris, Lihua Lyu, Yongyue Lu, Guojun Qi

Journal: Insect Sci

PubMed ID: 37933419

Doi: 10.1111/1744-7917.13291

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Mesenchymal stem cells attenuate systemic lupus erythematosus by inhibiting NLRP3 inflammasome activation through Pim-1 kinase

Authors: Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun

Journal: Int Immunopharmacol

PubMed ID: 37992447

Doi: 10.1016/j.intimp.2023.111256

Products & Services: Gene Synthesis

Human leukocyte antigen HLA-DR-expressing fibroblast-like synoviocytes are inducible antigen presenting cells that present autoantigens in Lyme arthritis

Authors: Joseph R Rouse, Rebecca Danner, Amanda Wahhab, Michaela Pereckas, Mecaila E McClune, Allen C Steere, Klemen Strle, Brandon L Jutras, Robert B Lochhead

Journal: biorxiv

PubMed ID: 38045407

Doi: 10.1101/2023.11.21.568066

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Biophysical and biochemical characterization of the thioredoxin system from Colwellia psychrerythraea

Authors: Naheda Sahtout, David A R Sanders

Journal: Proteins

PubMed ID: 37909486

Doi: 10.1002/prot.26627

Products & Services: Molecular Biology Reagents

A sensitive luciferase reporter assay for the detection of infectious African swine fever virus

Authors: Kemal Mehinagic, Matthias Liniger, Maksym Samoilenko, Nick Soltermann, Markus Gerber, Nicolas Ruggli

Journal: J Virol Methods

PubMed ID: 37989458

Doi: 10.1016/j.jviromet.2023.114854

Products & Services: Molecular Biology Reagents

Engineering self-deliverable ribonucleoproteins for genome editing in the brain

Authors: Kai Chen, Elizabeth C Stahl, Min Hyung Kang, Bryant Xu, Ryan Allen, Marena Trinidad, Jennifer A Doudna

Journal: biorxiv

PubMed ID: 38014180

Doi: 10.1101/2023.11.15.567251

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Isolation and characterisation of PR3-specific B cells and their immunoglobulin sequences

Authors: Shane Kelly, Katherine Jl Jackson, Timothy J Peters, Dan Suan, Christopher C Goodnow

Journal: J Autoimmun

PubMed ID: 37952292

Doi: 10.1016/j.jaut.2023.103129

Products & Services: DNA Sequencing

Extracellular and intracellular destruction of Pseudomonas aeruginosa by Dictyostelium discoideum phagocytes mobilize different antibacterial mechanisms

Authors: Imen Ayadi, Otmane Lamrabet, Raphael Munoz-Ruiz, Tania Jauslin, Cyril Guilhen, Pierre Cosson

Journal: Mol Microbiol

PubMed ID: 38017607

Doi: 10.1111/mmi.15197

Products & Services: Protein and Antibody Isolation

Phages overcome bacterial immunity via diverse anti-defence proteins

Authors: Erez Yirmiya, Azita Leavitt, Allen Lu, Adelyn E Ragucci, Carmel Avraham, Ilya Osterman, Jeremy Garb, Sadie P Antine, Sarah E Mooney, Samuel J Hobbs, Philip J Kranzusch, Gil Amitai, Rotem Sorek

Journal: Nature

PubMed ID: 37992756

Doi: 10.1038/s41586-023-06869-w

Products & Services: Gene Synthesis

RAGE Is a Receptor for SARS-CoV-2 N Protein and Mediates N Protein-induced Acute Lung Injury

Authors: Jie Xia, Jiangmei Wang, Liyang Ying, Ruoqiong Huang, Kai Zhang, Ruoyang Zhang, Wenqi Tang, Qi Xu, Dengming Lai, Yan Zhang, Yaoqin Hu, Xiaodie Zhang, Ruoxi Zang, Jiajie Fan, Qiang Shu, Jianguo Xu

Journal: Am J Respir Cell Mol Biol

PubMed ID: 37478333

Doi: 10.1165/rcmb.2022-0351OC

Products & Services: Recombinant Proteins

Plant carbonic anhydrase-like enzymes in neuroactive alkaloid biosynthesis

Authors: Ryan S Nett, Yaereen Dho, Chun Tsai, Daria Passow, Jaime Martinez Grundman, Yun-Yee Low, Elizabeth S Sattely

Journal: Nature

PubMed ID: 37938780

Doi: 10.1038/s41586-023-06716-y

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Conserved antigen structures and antibody-driven variations on foot-and-mouth disease virus serotype A revealed by bovine neutralizing monoclonal antibodies

Authors: Kun Li, Yong He, Li Wang, Pinghua Li, Huifang Bao, Shulun Huang, Shasha Zhou, Guoqiang Zhu, Yali Song, Ying Li, Sheng Wang, Qianliang Zhang, Pu Sun, Xingwen Bai, Zhixun Zhao, Zhiyong Lou, Yimei Cao, Zengjun Lu, Zaixin Liu

Journal: PLoS Pathog

PubMed ID: 37983290

Doi: 10.1371/journal.ppat.1011811

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ASPSCR-1 and Sirt-5 alleviate Clonorchis liver fluke rCsNOSIP-induced oxidative stress, proliferation, and migration in cholangiocarcinoma cells

Authors: Meng Bian, Shan Li, Hanzong Zhou, Lijun Bi, Yong Shen, Chen Tingjin, Xinbing Yu, Yan Huang, Qingxia Xu

Journal: PLoS Negl Trop Dis

PubMed ID: 37948465

Doi: 10.1371/journal.pntd.0011727

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Molecular basis for the catalytic mechanism of human neutral sphingomyelinases 1 (hSMPD2)

Authors: Jingbo Yi, Boya Qi, Jian Yin, Ruochong Li, Xudong Chen, Junhan Hu, Guohui Li, Sensen Zhang, Yuebin Zhang, Maojun Yang

Journal: Nat Commun

PubMed ID: 38012235

Doi: 10.1038/s41467-023-43580-w

Products & Services: Protein and Antibody Isolation

Cationic ribosomal proteins can inhibit pro-inflammatory action stimulated by LPS+HMGB1 and are hindered by advanced glycation end products

Authors: Masahiro Watanabe, Takao Toyomura, Hidenori Wake, Takashi Nishinaka, Omer Faruk Hatipoglu, Hideo Takahashi, Masahiro Nishibori, Shuji Mori

Journal: Biotechnol Appl Biochem

PubMed ID: 38010900

Doi: 10.1002/bab.2538

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Development of an Electrochemical, Aptamer-Based Sensor for Dynamic Detection of Neuropeptide Y

Authors: Jordan M Seibold, Sanduni W Abeykoon, Ashley E Ross, Ryan J White

Journal: ACS Sens

PubMed ID: 38033269

Doi: 10.1021/acssensors.3c00855

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Environment relevant exposure of perfluorooctanoic acid accelerates the growth of hepatocellular carcinoma cells through mammalian target of rapamycin (mTOR) signal pathway

Authors: Jiawei Hong, Xiaoyan Wang, Hangbiao Jin, Yuanchen Chen, Yifan Jiang, Keyi Du, Diyu Chen, Shusen Zheng, Linping Cao

Journal: Environ Pollut

PubMed ID: 37967710

Doi: 10.1016/j.envpol.2023.122910

Products & Services: Protein Electrophoresis and Western

Unlocking the potential of allogeneic Vδ2 T cells for ovarian cancer therapy through CD16 biomarker selection and CAR/IL-15 engineering

Authors: Derek Lee, Zachary Spencer Dunn, Wenbin Guo, Carl J Rosenthal, Natalie E Penn, Yanqi Yu, Kuangyi Zhou, Zhe Li, Feiyang Ma, Miao Li, Tsun-Ching Song, Xinjian Cen, Yan-Ruide Li, Jin J Zhou, Matteo Pellegrini, Pin Wang, Lili Yang

Journal: Nat Commun

PubMed ID: 37938576

Doi: 10.1038/s41467-023-42619-2

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MiR126-targeted-nanoparticles combined with PI3K/AKT inhibitor as a new strategy to overcome melanoma resistance

Authors: Maria Beatrice Arasi, Gabriele De Luca, Laura Chronopoulou, Francesca Pedini, Eleonora Petrucci, Michela Flego, Annarita Stringaro, Marisa Colone, Luca Pasquini, Massimo Spada, Valentina Lulli, Maria Chiara Perrotta, George Adrian Calin, Cleofe Palocci, Mauro Biffoni, Federica Felicetti, Nadia Felli

Journal: Mol Ther

PubMed ID: 37990493

Doi: 10.1016/j.ymthe.2023.11.021

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Structure-directed bioengineering the lid1 of cold-adapted Pseudomonas sp TB11 esterase to boost catalytic capacity

Authors: Linlin Sha, Wen-Sen He, Tian Zheng, Yang Fei, Yu Fang, Huqing Yang, Gang Chen

Journal: Int J Biol Macromol

PubMed ID: 37992944

Doi: 10.1016/j.ijbiomac.2023.128302

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Sulforaphene suppressed cell proliferation and promoted apoptosis of COV362 cells in endometrioid ovarian cancer

Authors: Hui-Yan Yu, Li Yang, Yuan-Cai Liu, Ai-Jun Yu

Journal: PeerJ

PubMed ID: 38025760

Doi: 10.7717/peerj.16308

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Isolation and characterization of the aspartame-degrading strain Pseudarthrobacter sp AS-1

Authors: Zhijian Ke, Junyun Song, Jingrui Ma, Mengting Wang, Haiguang Mao, Chunli Xia, Lili Qi, Yidong Zhou, Jinbo Wang

Journal: Environ Pollut

PubMed ID: 37944888

Doi: 10.1016/j.envpol.2023.122883

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Denovo production of resveratrol by engineered Saccharomyces cerevisiae W303-1a using pretreated Gracilaria corticata extracts

Authors: Nishanthika Thenmozhi Kulasekaran, Mary Leema Thilakam, Dharani Gopal, Jung-Kul Lee, Jeya Marimuthu

Journal: Biotechnol Lett

PubMed ID: 37987932

Doi: 10.1007/s10529-023-03441-4

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A streamlined, automated workflow to screen and triage large numbers of baculoviruses for protein expression

Authors: James J Kostas, Andrea T Partridge, Noel J Byrne, Richard W Edwards, Hua-Poo Su, Sandra B Gabelli, Alexei Brooun, Jennifer M Shipman

Journal: Protein Expr Purif

PubMed ID: 37995943

Doi: 10.1016/j.pep.2023.106406

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Prenatal diagnostic approaches diagnosed craniosynostosis and identified a novel nonsense variant in SMAD6 in a Chinese fetus

Authors: Zhidan Hong, Xuanyi He, Jie Duan, Fang Yu, Huanyu Liu, Dan Lu, Mei Wang, Yuanzhen Zhang

Journal: Gene

PubMed ID: 37977316

Doi: 10.1016/j.gene.2023.147994

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A second-generation M1-polarized CAR macrophage with antitumor efficacy

Authors: Anhua Lei, Hua Yu, Shan Lu, Hengxing Lu, Xizhong Ding, Tianyu Tan, Hailing Zhang, Mengmeng Zhu, Lin Tian, Xudong Wang, Siyu Su, Dixuan Xue, Shaolong Zhang, Wei Zhao, Yuge Chen, Wanrun Xie, Li Zhang, Yuqing Zhu, Jing Zhao, Wenhong Jiang, George Church, Francis Ka-Ming Chan, Zhihua Gao, Jin Zhang

Journal: Nat Immunol

PubMed ID: 38012418

Doi: 10.1038/s41590-023-01687-8

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