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Hemophore-like proteins produced by periodontopathogens are recognized by the host immune system and react differentially with IgG antibodies
Authors: Michał Śmiga, Klaudia Siemińska, Soraya C Trindade, Isaac S Gomes-Filho, Ellen K Nobre Dos Santos, Teresa Olczak
Journal: J Oral Microbiol
PubMed ID: 37213663
Doi: 10.1080/20002297.2023.2214455
Products & Services: Peptide Synthesis   
Rapid Quantitation of Various Therapeutic Monoclonal Antibodies Using Membranes with Fc-Specific Ligands
Authors: Junyan Yang, Raluca Ostafe, Christopher J Welch, Brandy Verhalen, Ivan L Budyak, Merlin L Bruening
Journal: Anal Chem
PubMed ID: 37216615
Doi: 10.1021/acs.analchem.3c00531
Products & Services: Peptide Synthesis   
Hijacking of Host Plasminogen by () via GAPDH: an Important Virulence Mechanism To Promote Adhesion and Extracellular Matrix Degradation
Authors: Jiying Wang, Shiyang Li, Junhong Chen, Lanxi Gan, Jia Wang, Qiyan Xiong, Zhixin Feng, Quan Li, Zhibang Deng, Xiaomin Yuan, Yanfei Yu
Journal: Microbiol Spectr
PubMed ID: 37199643
Doi: 10.1128/spectrum.00218-23
Products & Services: Molecular Biology Reagents   
Ionic displacement of Ca by Pb in calmodulin is affected by arrhythmia-associated mutations
Authors: Valerio Marino, Giuditta Dal Cortivo, Daniele Dell'Orco
Journal: Biochim Biophys Acta Mol Cell Res
PubMed ID: 37201768
Doi: 10.1016/j.bbamcr.2023.119490
Products & Services: Codon Optimization   
KREH1 RNA helicase activity promotes utilization of initiator gRNAs across multiple mRNAs in trypanosome RNA editing
Authors: Ashutosh P Dubey, Brianna L Tylec, Amartya Mishra, Katherine Sortino, Runpu Chen, Yijun Sun, Laurie K Read
Journal: Nucleic Acids Research
PubMed ID: 37140035
Doi: doi.org/10.1093/nar/gkad292
Products & Services: Gene Synthesis   
Mechanism of assembly, activation and lysine selection by the SIN3B histone deacetylase complex
Authors: Mandy S M Wan, Reyhan Muhammad, Marios G Koliopoulos, Theodoros I Roumeliotis, Jyoti S Choudhary, Claudio Alfieri
Journal: nature communications
PubMed ID: 37137925
Doi: 10.1038/s41467-023-38276-0
Products & Services: Gene Synthesis   
Ligand and G-protein selectivity in the κ-opioid receptor
Authors: Jianming Han, Jingying Zhang, Antonina L Nazarova, Sarah M Bernhard, Brian E Krumm, Lei Zhao, Jordy Homing Lam, Vipin A Rangari, Susruta Majumdar, David E Nichols, Vsevolod Katritch, Peng Yuan, Jonathan F Fay, Tao Che
Journal: Nature
PubMed ID: 37138078
Doi: 10.1038/s41586-023-06030-7
Diversity and Genetic Reassortment of Keystone Virus in Mosquito Populations in Florida
Authors: Maha A Elbadry, Caroline A Efstathion, Whitney A Qualls, Massimiliano S Tagliamonte, Md Mahbubul Alam, Md Siddiqur Rahman Khan, Sadie J Ryan, Rui-de Xue, Remi N Charrel, Lea Bangonan, Marco Salemi, Nazli Ayhan, John A Lednicky, J Glenn Morris
Journal: Am J Trop Med Hyg
PubMed ID: 37127267
Doi: 10.4269/ajtmh.22-0594
Bioluminescence resonance energy transfer biosensor for measuring activity of a protease secreted by Pseudomonas fluorescens growing in milk
Authors: H Dacres, F Weihs, J Wang, A Anderson, S C Trowell
Journal: Anal Chim Acta
PubMed ID: 37311608
Doi: 10.1016/j.aca.2023.341401
Photobiomodulation therapy at 632 nm wavelength ameliorates intrauterine adhesion via activation of cAMP/PKA/CREB pathway
Authors: Hongjie Zheng, Caixia Wang, Shan Wu, Qing Pei, Min Yao
Journal: Photochem Photobiol
PubMed ID: 37212452
Doi: 10.1111/php.13813
Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma
Authors: Damon A Hofman, Jorge Ruiz-Orera, Ian Yannuzzi, Rakesh Murugesan, Adam Brown, Karl R Clauser, Alexandra L Condurat, Jip T van Dinter, Sem A G Engels, Amy Goodale, Jasper van der Lugt, Tanaz Abid, Li Wang, Kevin N Zhou, Jayne Vogelzang, Keith L Ligon, Timothy N Phoenix, Jennifer A Roth, David E Root, Norbert Hubner, Todd R Golub, Pratiti Bandopadhayay, Sebastiaan van Heesch, John R Prensner
Journal: biorxiv
PubMed ID: 37205492
Doi: 10.1101/2023.05.04.539399
The secretory IgA (sIgA) response in human milk against the SARS-CoV-2 Spike is highly durable and neutralizing for at least 1 year of lactation post-infection
Authors: Xiaoqi Yang, Alisa Fox, Claire DeCarlo, Nicole Pineda, Rebecca L R Powell
Journal: medrxiv
PubMed ID: 37293109
Doi: 10.1101/2023.05.19.23290192
Characterisation of IL-23 receptor antagonists and disease relevant mutants using fluorescent probes
Authors: Charles S Lay, Albert Isidro-Llobet, Laura E Kilpatrick, Peter D Craggs, Stephen J Hill
Journal: Nat Commun
PubMed ID: 37208328
Doi: 10.1038/s41467-023-38541-2
Screening and characterization of the scFv for chimeric antigen receptor T cells targeting CEA-positive carcinoma
Authors: Chengcheng Zhang, Linling Wang, Qianzhen Zhang, Junjie Shen, Xia Huang, Meiling Wang, Yi Huang, Jun Chen, Yanmin Xu, Wenxu Zhao, Yanan Qi, Yunyan Li, Yanjiao Ou, Zhi Yang, Cheng Qian
Journal: Front Immunol
PubMed ID: 37304295
Doi: 10.3389/fimmu.2023.1182409
Products & Services: Insect Expression   
Molecular cloning and in silico analysis of chalcone isomerase from Polygonum minus
Authors: Fatin Lyana Azman Shah, Syarul Nataqain Baharum, Hoe-Han Goh, Thean Chor Leow, Ahmad Bazli Ramzi, Siti Nurbaya Oslan, Suriana Sabri
Journal: Mol Biol Rep
PubMed ID: 37148413
Doi: 10.1007/s11033-023-08417-1
Products & Services: Recombinant Proteins   
Structural basis for pre-tRNA recognition and processing by the human tRNA splicing endonuclease complex
Authors: Cassandra K Hayne, Kevin John U Butay, Zachary D Stewart, Juno M Krahn, Lalith Perera, Jason G Williams, Robert M Petrovitch, Leesa J Deterding, A Gregory Matera, Mario J Borgnia, Robin E Stanley
Journal: Nat Struct Mol Biol
PubMed ID: 37231153
Doi: 10.1038/s41594-023-00991-z
Products & Services: Gene Synthesis   
GNAQ-Regulated ZO-1 and ZO-2 Act as Tumor Suppressors by Modulating EMT Potential and Tumor-Repressive Microenvironment in Lung Cancer
Authors: Hyung Seok Kim, Su In Lee, Yu Rim Choi, Jiyun Kim, Jung Woo Eun, Kyoung Seob Song, Jee-Yeong Jeong
Journal: Int J Mol Sci
PubMed ID: 37240145
Doi: 10.3390/ijms24108801
Products & Services: Recombinant Proteins   
Engineered ketocarotenoid biosynthesis in the polyextremophilic red microalga Cyanidioschyzon merolae 10D
Authors: Mark Seger , Fakhriyya Mammadova , Melany Villegas-Valencia , Barbara ´ Bastos de Freitas , Clarissa Chang , Iona Isachsen , Haley Hemstreet , Fatimah Abualsaud , Malia Boring , Peter J. Lammers , Kyle J. Lauersen
Journal: Metabolic Engineering Communications
Doi: 10.1016/j.mec.2023.e00226
Products & Services: Gene Synthesis   
MASP3 Deficiency in Mice Reduces but Does Not Abrogate Alternative Pathway Complement Activity Due to Intrinsic Profactor D Activity
Authors: Damodar Gullipalli, Takashi Miwa, Madhu Golla, Sayaka Sato, Sree Angampalli, Wen-Chao Song
Journal: J Immunol
PubMed ID: 36988282
Doi: 10.4049/jimmunol.2200932
Products & Services: Gene Synthesis   
Development and characterization of nanobodies that specifically target the oncogenic Phosphatase of Regenerating Liver-3 (PRL-3) and impact its interaction with a known binding partner, CNNM3
Authors: Caroline N Smith, Kyle Kihn, Zachary A Williamson, K Martin Chow, Louis B Hersh, Konstantin V Korotkov, Daniel Deredge, Jessica S Blackburn
Journal: PLoS ONE
PubMed ID: 37220097
Doi: 10.1371/journal.pone.0285964
Ovarian juvenile granulosa cell tumors with Ollier's disease in children with IDH1 gene somatic mutation
Authors: Jin Zhang, Renwu Hua, Lishuang Ma, Chao Liu, Yanxia Zhang, Xuemin Lü, Tianren Wang, Naijun Wan
Journal: Front Endocrinol (Lausanne)
PubMed ID: 37324278
Doi: 10.3389/fendo.2023.1093273
Prognostic impact of kallikrein-related peptidase transcript levels in prostate cancer
Authors: Timo-Pekka K Lehto, Ruusu-Maaria Kovanen, Susanna Lintula, Adrian Malén, Carolin Stürenberg, Andrew Erickson, Olli-Pekka Pulkka, Ulf-Håkan Stenman, Eleftherios P Diamandis, Antti Rannikko, Tuomas Mirtti, Hannu Koistinen
Journal: Int J Cancer
PubMed ID: 37139608
Doi: 10.1002/ijc.34551
Products & Services: Molecular Biology Reagents   
Synthesis and Evaluation of Clinically Translatable Targeted Microbubbles Using a Microfluidic Device for In Vivo Ultrasound Molecular Imaging
Authors: Rakesh Bam, Arutselvan Natarajan, Farbod Tabesh, Ramasamy Paulmurugan, Jeremy J Dahl
Journal: Int J Mol Sci
PubMed ID: 37240396
Doi: 10.3390/ijms24109048
Products & Services: Recombinant Proteins   
Soluble monomeric human programmed cell death-ligand 1 inhibits the functions of activated T cells
Authors: Zhaoduan Liang, Wenfang Chen, Yunzhuo Guo, Yuefei Ren, Ye Tian, Wenxuan Cai, Yifeng Bao, Qi Liu, Peng Ding, Yi Li
Journal: Front Immunol
PubMed ID: 37266424
Doi: 10.3389/fimmu.2023.1133883
Products & Services: Stable Cell Lines   
Identification of new conserved linear B-cell epitopes in the 3AB and 3C protein of Senecavirus A
Authors: Jian Li, Junfang Yan, Yanni Gao, Xing Liu, Haifeng Sun, Juan Bai, Ping Jiang
Journal: Vet Microbiol
PubMed ID: 37263042
Doi: 10.1016/j.vetmic.2023.109780
Products & Services: Custom DNA/RNA Oligos   
BcMYB111 Responds to BcCBF2 and Induces Flavonol Biosynthesis to Enhance Tolerance under Cold Stress in Non-Heading Chinese Cabbage
Authors: Xiaoshan Chen , Ying Wu , Zhanghong Yu , Zhanyuan Gao , Qiang Ding , Sayyed Hamad Ahmad Shah , Wenyuan Lin , Ying Li , Xilin Hou
Journal: Int J Mol Sci .
PubMed ID: 37240015
Doi: 10.3390/ijms24108670
Products & Services: Gene Synthesis   
Co-delivery of Cas9 mRNA and guide RNAs edits hepatitis B virus episomal and integration DNA in mouse and tree shrew models
Authors: Junzhu Yi, Xinlin Lei, Fangteng Guo, Qiubing Chen, Xueyong Chen, Kaitao Zhao, Chengliang Zhu, Xiaoming Cheng, Jiangwei Lin, Hao Yin, Yuchen Xia
Journal: Antiviral research
PubMed ID: 37142191
Doi: 10.1016/j.antiviral.2023.105618
Products & Services: CRISPR RNAs/Cas9 Proteins(INACTIVE)   
Functionalized Metal–Organic Framework-Modified Hydrogel That Breaks the Vicious Cycle of Inflammation and ROS for Repairing of Diabetic Bone Defects
Authors: An Lao, Jiaqing Wu, Dejian Li, Aili Shen, Yaxin Li, Yu Zhuang, Kaili Lin, Jianyong Wu, Jiaqiang Liu
Journal: Small
PubMed ID: 37183293
Doi: smll.202206919
Topically Administered NOX4 Inhibitor, GLX7013114, Is Efficacious in Treating the Early Pathological Events of Diabetic Retinopathy
Authors: Stavroula Dionysopoulou, Per Wikstrom, Claudio Bucolo, Giovanni Luca Romano, Vincenzo Micale, Richard Svensson, Dimitris Spyridakos, Niki Mastrodimou, Spiros Georgakis, Panayotis Verginis, Erik Walum, Kyriaki Thermos
Journal: Diabetes
PubMed ID: 36821829
Doi: 10.2337/db22-0515
The Nucleocapsid Proteins of SARS-CoV-2 and Its Close Relative Bat Coronavirus RaTG13 Are Capable of Inhibiting PKR- and RNase L-Mediated Antiviral Pathways
Authors: Kyle LeBlanc, Jessie Lynch, Christine Layne, Robert Vendramelli, Angela Sloan, Nikesh Tailor, Yvon Deschambault, Fushun Zhang, Darwyn Kobasa, David Safronetz, Yan Xiang, Jingxin Cao
Journal: Microbiol Spectr
PubMed ID: 37154717
Doi: 10.1128/spectrum.00994-23
Redundant actions of neuropeptides encoded by the dh-pban gene for larval color pattern formation in the oriental armyworm Mythimnaseparata
Authors: Yu Shirai, Hajime Ono, Takaaki Daimon
Journal: Insect Biochem Mol Biol
PubMed ID: 37146697
Doi: 10.1016/j.ibmb.2023.103955
Products & Services: Peptide Synthesis   
Detection of viral RNAs at ambient temperature via reporter proteins produced through the target-splinted ligation of DNA probes
Authors: Elizabeth A Phillips, Adam D Silverman, Aric Joneja, Michael Liu, Carl Brown, Paul Carlson, Christine Coticchia, Kristen Shytle, Alex Larsen, Nadish Goyal, Vincent Cai, Jason Huang, Jennifer E Hickey, Emily Ryan, Joycelynn Acheampong, Pradeep Ramesh, James J Collins, William J Blake
Journal: Nat Biomed Eng
PubMed ID: 37142844
Doi: 10.1038/s41551-023-01028-y
Design and development of microformulations for rapid release of small molecules and oligonucleotides
Authors: T Brown, M Stanton, F Cros, S Cho, A Kiselyov
Journal: Eur J Pharm Sci
PubMed ID: 37220816
Doi: 10.1016/j.ejps.2023.106472
Modeling cell-mediated immunity in human type 1 diabetes by engineering autoreactive CD8 T cells
Authors: Leeana D Peters, Wen-I Yeh, Juan M Arnoletti, Matthew E Brown, Amanda L Posgai, Clayton E Mathews, Todd M Brusko
Journal: Front Immunol
PubMed ID: 37325626
Doi: 10.3389/fimmu.2023.1142648
Products & Services: Peptide Synthesis   
Soluble TREM-like Transcript-1 Acts as a Damage-Associated Molecular Pattern through the TLR4/MD2 Pathway Contributing to Immune Dysregulation during Sepsis
Authors: Chia-Ming Chang, Kuang-Hua Cheng, Tsai-Yin Wei, Meng-Ping Lu, Yi-Chen Chen, Yen-Ta Lu
Journal: J Immunol
PubMed ID: 36961438
Doi: 10.4049/jimmunol.2200222
Fusion of the molecular adjuvant C3d to cleavage-independent native-like HIV-1 Env trimers improves the elicited antibody response
Authors: Shridhar Bale, Lifei Yang, Mehrdad Alirezaei, Richard Wilson, Takayuki Ota, Esmeralda D Doyle, Christopher A Cottrell, Javier Guenaga, Karen Tran, Wenjuan Li, Leonidas Stamatatos, David Nemazee, Andrew B Ward, Richard T Wyatt
Journal: Front Immunol
PubMed ID: 37283743
Doi: 10.3389/fimmu.2023.1180959
CFTR and dystrophin encoding plasmids carrying both luciferase reporter gene, nuclear import specific sequences and triple helix sites
Authors: Delphine Maze, Caroline Girardin, Nathalie Benz, Tristan Montier, Chantal Pichon, Patrick Midoux
Journal: Plasmid
PubMed ID: 37207938
Doi: 10.1016/j.plasmid.2023.102686
Small heterodimer partner interacting leucine zipper protein (SMILE) ameliorates autoimmune arthritis via AMPK signaling pathway and the regulation of B cell activation
Authors: JooYeon Jhun, Jeonghyeon Moon, Ji Ye Kwon, Keun-Hyung Cho, Seang Yoon Lee, Hyun Sik Na, Mi-La Cho, Jun-Ki Min
Journal: Cell Commun Signal
PubMed ID: 37143079
Doi: 10.1186/s12964-023-01054-y
Products & Services: Codon Optimization   
GSK3 phosphorylates and regulates the Green Revolution protein Rht-B1b to reduce plant height in wheat
Authors: Huixue Dong, Danping Li, Ruizhen Yang, Lichao Zhang, Yunwei Zhang, Xu Liu, Xiuying Kong, Jiaqiang Sun
Journal: Plant Cell
PubMed ID: 36945740
Doi: 10.1093/plcell/koad090
Products & Services: Recombinant Proteins   
Predictive data-driven modeling of C-terminal tyrosine function in the EGFR signaling network
Authors: Jacqueline S Gerritsen, Joseph S Faraguna, Rudy Bonavia, Frank B Furnari, Forest M White
Journal: Life Sci Alliance
PubMed ID: 37169593
Doi: 10.26508/lsa.202201466
Products & Services: Stable Cell Lines   
Deep sampling of gRNA in the human genome and deep-learning-informed prediction of gRNA activities
Authors: Heng Zhang, Jianfeng Yan, Zhike Lu, Yangfan Zhou, Qingfeng Zhang, Tingting Cui, Yini Li, Hui Chen, Lijia Ma
Journal: Cell Discov
PubMed ID: 37193681
Doi: 10.1038/s41421-023-00549-9
Products & Services: Gene Synthesis   
Engineering Rapalog-Inducible Genetic Switches Based on Split-T7 Polymerase to Regulate Oncolytic Virus-Driven Production of Tumour-Localized IL-12 for Anti-Cancer Immunotherapy
Authors: Nikolas T Martin, Mathieu J F Crupi, Zaid Taha, Joanna Poutou, Jack T Whelan, Sydney Vallati, Julia Petryk, Ricardo Marius, Bradley Austin, Taha Azad, Mason Boulanger, Tamara Burgess, Ilson Sanders, Camille Victoor, Bryan C Dickinson, Jean-Simon Diallo, Carolina S Ilkow, John C Bell
Journal: Pharmaceuticals (Basel)
PubMed ID: 37242495
Doi: 10.3390/ph16050709
Products & Services: Recombinant Proteins   
Evaluation of humoral and cellular immune responses induced by a cocktail of recombinant African swine fever virus antigens fused with OprI in domestic pigs
Authors: Guanglei Zhang, Wei Liu, Sicheng Yang, Shuai Song, Yunyun Ma, Guangqing Zhou, Xiaxia Liang, Chun Miao, Junhui Li, Yanhong Liu, Junjun Shao, Huiyun Chang
Journal: Virol J
PubMed ID: 37237390
Doi: 10.1186/s12985-023-02070-7
Products & Services: DNA Sequencing   
Immunogenic SARS-CoV-2 S and N Protein Peptide and Cytokine Combinations as Biomarkers for Early Prediction of Fatal COVID-19
Authors: Ekaterina Martynova , Shaimaa Hamza , Maria Markelova , Ekaterina Garanina , Yuriy Davidyuk , Venera Shakirova , Neha Kaushal , Manoj Baranwal , Robert J Stott-Marshall , Toshana L Foster , Albert Rizvanov , Svetlana Khaiboullina
Journal: Front Immunol .
PubMed ID: 35386707
Doi: 10.3389/fimmu.2022.830715
Products & Services: Peptide Synthesis   
In vitro reconstitution of SARS-CoV-2 Nsp1-induced mRNA cleavage reveals the key roles of the N-terminal domain of Nsp1 and the RRM domain of eIF3g
Authors: Irina S. Abaeva, Yani Arhab, Anna Miscicka, Christopher U.T. Hellen, and Tatyana V. Pestova
Journal: bioRxiv .
PubMed ID: 37292671
Doi: 10.1101/gad.350829.123
Products & Services: Gene Synthesis   
KRAS mutation-induced TOPK overexpression contributes to tumour progression in non-small cell lung cancer
Authors: Chang Cai, Shuo Yao, Yanmei Zou, Hui Lu, Xiuqiong Chen, Yali Wang, Kun Zheng, Feng Zhu, Yihua Wang, Hua Xiong, Junfei Zhu
Journal: J Cell Mol Med
PubMed ID: 37226642
Doi: 10.1111/jcmm.17640
Rescue of secretion of a rare-disease associated mis-folded mutant glycoprotein in knock-out mammalian cells
Authors: Gábor Tax, Kevin P Guay, Tatiana Soldà, Charlie J Hitchman, Johan C Hill, Snežana Vasiljević, Andrea Lia, Carlos P Modenutti, Kees R Straatman, Angelo Santino, Maurizio Molinari, Nicole Zitzmann, Daniel N Hebert, Pietro Roversi, Marco Trerotola
Journal: biorxiv
PubMed ID: 37398215
Doi: 10.1101/2023.05.30.542711
Enhanced stability of the SARS CoV-2 spike glycoprotein following modification of an alanine cavity in the protein core
Authors: Pantelis Poumbourios, Christine Langer, Irene Boo, Tasnim Zakir, Rob J Center, Anouschka Akerman, Vanessa Milogiannakis, Anupriya Aggarwal, Bronte A Johnstone, Jungmin Ha, Fasséli Coulibaly, Stuart G Turville, Heidi E Drummer
Journal: PLoS Pathog
PubMed ID: 37200378
Doi: 10.1371/journal.ppat.1010981
The E3 Ubiquitin Ligase SCF Cyclin F Promotes Sequestosome-1/p62 Insolubility and Foci Formation and is Dysregulated in ALS and FTD Pathogenesis
Authors: Jennilee M Davidson, Sharlynn S L Wu, Stephanie L Rayner, Flora Cheng, Kimberley Duncan, Carlo Russo, Michelle Newbery, Kunjie Ding, Natalie M Scherer, Rachelle Balez, Alberto García-Redondo, Alberto Rábano, Livia Rosa-Fernandes, Lezanne Ooi, Kelly L Williams, Marco Morsch, Ian P Blair, Antonio Di Ieva, Shu Yang, Roger S Chung, Albert Lee
Journal: Mol Neurobiol
PubMed ID: 37243816
Doi: 10.1007/s12035-023-03355-2
saRNA vaccine expressing membrane-anchored RBD elicits broad and durable immunity against SARS-CoV-2 variants of concern
Authors: Mai Komori, Takuto Nogimori, Amber L Morey, Takashi Sekida, Keiko Ishimoto, Matthew R Hassett, Yuji Masuta, Hirotaka Ode, Tomokazu Tamura, Rigel Suzuki, Jeff Alexander, Yasutoshi Kido, Kenta Matsuda, Takasuke Fukuhara, Yasumasa Iwatani, Takuya Yamamoto, Jonathan F Smith, Wataru Akahata
Journal: Nat Commun
PubMed ID: 37208330
Doi: 10.1038/s41467-023-38457-x

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