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Redundant actions of neuropeptides encoded by the dh-pban gene for larval color pattern formation in the oriental armyworm Mythimnaseparata
Authors: Yu Shirai, Hajime Ono, Takaaki Daimon
Journal: Insect Biochem Mol Biol
PubMed ID: 37146697
Doi: 10.1016/j.ibmb.2023.103955
Products & Services: Peptide Synthesis   
Detection of viral RNAs at ambient temperature via reporter proteins produced through the target-splinted ligation of DNA probes
Authors: Elizabeth A Phillips, Adam D Silverman, Aric Joneja, Michael Liu, Carl Brown, Paul Carlson, Christine Coticchia, Kristen Shytle, Alex Larsen, Nadish Goyal, Vincent Cai, Jason Huang, Jennifer E Hickey, Emily Ryan, Joycelynn Acheampong, Pradeep Ramesh, James J Collins, William J Blake
Journal: Nat Biomed Eng
PubMed ID: 37142844
Doi: 10.1038/s41551-023-01028-y
Modeling cell-mediated immunity in human type 1 diabetes by engineering autoreactive CD8 T cells
Authors: Leeana D Peters, Wen-I Yeh, Juan M Arnoletti, Matthew E Brown, Amanda L Posgai, Clayton E Mathews, Todd M Brusko
Journal: Front Immunol
PubMed ID: 37325626
Doi: 10.3389/fimmu.2023.1142648
Products & Services: Peptide Synthesis   
Soluble TREM-like Transcript-1 Acts as a Damage-Associated Molecular Pattern through the TLR4/MD2 Pathway Contributing to Immune Dysregulation during Sepsis
Authors: Chia-Ming Chang, Kuang-Hua Cheng, Tsai-Yin Wei, Meng-Ping Lu, Yi-Chen Chen, Yen-Ta Lu
Journal: J Immunol
PubMed ID: 36961438
Doi: 10.4049/jimmunol.2200222
Leveraging a Structural Blueprint to Rationally Engineer the Rieske Oxygenase TsaM
Authors: Jiayi Tian, Alejandro Arcadio Garcia, Patrick H Donnan, Jennifer Bridwell-Rabb
Journal: Biochemistry
PubMed ID: 37188334
Doi: 10.1021/acs.biochem.3c00150
Antigen-Induced IL-1RA Production Discriminates Active and Latent Tuberculosis Infection
Authors: Cesar Sanchez, Luis Jaramillo-Valverde, Silvia Capristano, Gilmer Solis, Alonso Soto, Julio Valdivia-Silva, Julio A Poterico, Heinner Guio
Journal: Microorganisms
PubMed ID: 37374887
Doi: 10.3390/microorganisms11061385
Products & Services: Peptide Synthesis   
Antibody blockade of Jagged1 attenuates choroidal neovascularization
Authors: Torleif Tollefsrud Gjølberg, Jonas Aakre Wik, Hanna Johannessen, Stig Krüger, Nicola Bassi, Panagiotis F Christopoulos, Malin Bern, Stian Foss, Goran Petrovski, Morten C Moe, Guttorm Haraldsen, Johanna Hol Fosse, Bjørn Steen Skålhegg, Jan Terje Andersen, Eirik Sundlisæter
Journal: Nat Commun
PubMed ID: 37253747
Doi: 10.1038/s41467-023-38563-w
Small heterodimer partner interacting leucine zipper protein (SMILE) ameliorates autoimmune arthritis via AMPK signaling pathway and the regulation of B cell activation
Authors: JooYeon Jhun, Jeonghyeon Moon, Ji Ye Kwon, Keun-Hyung Cho, Seang Yoon Lee, Hyun Sik Na, Mi-La Cho, Jun-Ki Min
Journal: Cell Commun Signal
PubMed ID: 37143079
Doi: 10.1186/s12964-023-01054-y
Products & Services: Codon Optimization   
Connexin 37 sequestering of activated-ERK in the cytoplasm promotes p27-mediated endothelial cell cycle arrest
Authors: Bipul R Acharya, Jennifer S Fang, Erin D Jeffery, Nicholas W Chavkin, Gael Genet, Hema Vasavada, Elizabeth A Nelson, Gloria M Sheynkman, Martin J Humphries, Karen K Hirschi
Journal: Life Sci Alliance
PubMed ID: 37197981
Doi: 10.26508/lsa.202201685
Products & Services: Molecular Biology Reagents   
Conserved cardiolipin-mitochondrial ADP/ATP carrier interactions assume distinct structural and functional roles that are clinically relevant
Authors: Nanami Senoo, Dinesh K Chinthapalli, Matthew G Baile, Vinaya K Golla, Bodhisattwa Saha, Oluwaseun B Ogunbona, James A Saba, Teona Munteanu, Yllka Valdez, Kevin Whited, Dror Chorev, Nathan N Alder, Eric R May, Carol V Robinson, Steven M Claypool
Journal: biorxiv
PubMed ID: 37205478
Doi: 10.1101/2023.05.05.539595
Products & Services: Molecular Biology Reagents   
GSK3 phosphorylates and regulates the Green Revolution protein Rht-B1b to reduce plant height in wheat
Authors: Huixue Dong, Danping Li, Ruizhen Yang, Lichao Zhang, Yunwei Zhang, Xu Liu, Xiuying Kong, Jiaqiang Sun
Journal: Plant Cell
PubMed ID: 36945740
Doi: 10.1093/plcell/koad090
Products & Services: Recombinant Proteins   
A highly efficient transgene knock-in technology in clinically relevant cell types
Authors: Alexander G Allen, Samia Q Khan, Carrie M Margulies, Ramya Viswanathan, Swarali Lele, Laura Blaha, Sean N Scott, Kaitlyn M Izzo, Alexandra Gerew, Rithu Pattali, Nadire R Cochran, Carl S Holland, Amy H Zhao, Stephen E Sherman, Michael C Jaskolka, Meng Wu, Aaron C Wilson, Xiaoqi Sun, Dawn M Ciulla, Deric Zhang, Jacqueline D Nelson, Peisheng Zhang, Patrizia Mazzucato, Yan Huang, Georgia Giannoukos, Eugenio Marco, Michael Nehil, John A Follit, Kai-Hsin Chang, Mark S Shearman, Christopher J Wilson, John A Zuris
Journal: Nat Biotechnol
PubMed ID: 37127662
Doi: 10.1038/s41587-023-01779-8
Products & Services: Gene Synthesis   
Deep learning models to predict the editing efficiencies and outcomes of diverse base editors
Authors: Nahye Kim, Sungchul Choi, Sungjae Kim, Myungjae Song, Jung Hwa Seo, Seonwoo Min, Jinman Park, Sung-Rae Cho, Hyongbum Henry Kim
Journal: Nat Biotechnol
PubMed ID: 37188916
Doi: 10.1038/s41587-023-01792-x
Products & Services: Gene Synthesis   
Structure of a 10-23 Deoxyribozyme Exhibiting a Homodimer Conformation
Authors: Evan Cramer, Sarah Starcovic, Rebekah Avey, Ali Kaya, Aaron Robart
Journal: Res Sq
PubMed ID: 37398199
Doi: 10.21203/rs.3.rs-2252941/v1
Products & Services: Gene Synthesis   
Engineering Rapalog-Inducible Genetic Switches Based on Split-T7 Polymerase to Regulate Oncolytic Virus-Driven Production of Tumour-Localized IL-12 for Anti-Cancer Immunotherapy
Authors: Nikolas T Martin, Mathieu J F Crupi, Zaid Taha, Joanna Poutou, Jack T Whelan, Sydney Vallati, Julia Petryk, Ricardo Marius, Bradley Austin, Taha Azad, Mason Boulanger, Tamara Burgess, Ilson Sanders, Camille Victoor, Bryan C Dickinson, Jean-Simon Diallo, Carolina S Ilkow, John C Bell
Journal: Pharmaceuticals (Basel)
PubMed ID: 37242495
Doi: 10.3390/ph16050709
Products & Services: Recombinant Proteins   
Evaluation of humoral and cellular immune responses induced by a cocktail of recombinant African swine fever virus antigens fused with OprI in domestic pigs
Authors: Guanglei Zhang, Wei Liu, Sicheng Yang, Shuai Song, Yunyun Ma, Guangqing Zhou, Xiaxia Liang, Chun Miao, Junhui Li, Yanhong Liu, Junjun Shao, Huiyun Chang
Journal: Virol J
PubMed ID: 37237390
Doi: 10.1186/s12985-023-02070-7
Products & Services: DNA Sequencing   
Design and development of microformulations for rapid release of small molecules and oligonucleotides
Authors: T Brown, M Stanton, F Cros, S Cho, A Kiselyov
Journal: Eur J Pharm Sci
PubMed ID: 37220816
Doi: 10.1016/j.ejps.2023.106472
Enhanced stability of the SARS CoV-2 spike glycoprotein following modification of an alanine cavity in the protein core
Authors: Pantelis Poumbourios, Christine Langer, Irene Boo, Tasnim Zakir, Rob J Center, Anouschka Akerman, Vanessa Milogiannakis, Anupriya Aggarwal, Bronte A Johnstone, Jungmin Ha, Fasséli Coulibaly, Stuart G Turville, Heidi E Drummer
Journal: PLoS Pathog
PubMed ID: 37200378
Doi: 10.1371/journal.ppat.1010981
Rescue of secretion of a rare-disease associated mis-folded mutant glycoprotein in knock-out mammalian cells
Authors: Gábor Tax, Kevin P Guay, Tatiana Soldà, Charlie J Hitchman, Johan C Hill, Snežana Vasiljević, Andrea Lia, Carlos P Modenutti, Kees R Straatman, Angelo Santino, Maurizio Molinari, Nicole Zitzmann, Daniel N Hebert, Pietro Roversi, Marco Trerotola
Journal: biorxiv
PubMed ID: 37398215
Doi: 10.1101/2023.05.30.542711
The E3 Ubiquitin Ligase SCF Cyclin F Promotes Sequestosome-1/p62 Insolubility and Foci Formation and is Dysregulated in ALS and FTD Pathogenesis
Authors: Jennilee M Davidson, Sharlynn S L Wu, Stephanie L Rayner, Flora Cheng, Kimberley Duncan, Carlo Russo, Michelle Newbery, Kunjie Ding, Natalie M Scherer, Rachelle Balez, Alberto García-Redondo, Alberto Rábano, Livia Rosa-Fernandes, Lezanne Ooi, Kelly L Williams, Marco Morsch, Ian P Blair, Antonio Di Ieva, Shu Yang, Roger S Chung, Albert Lee
Journal: Mol Neurobiol
PubMed ID: 37243816
Doi: 10.1007/s12035-023-03355-2
saRNA vaccine expressing membrane-anchored RBD elicits broad and durable immunity against SARS-CoV-2 variants of concern
Authors: Mai Komori, Takuto Nogimori, Amber L Morey, Takashi Sekida, Keiko Ishimoto, Matthew R Hassett, Yuji Masuta, Hirotaka Ode, Tomokazu Tamura, Rigel Suzuki, Jeff Alexander, Yasutoshi Kido, Kenta Matsuda, Takasuke Fukuhara, Yasumasa Iwatani, Takuya Yamamoto, Jonathan F Smith, Wataru Akahata
Journal: Nat Commun
PubMed ID: 37208330
Doi: 10.1038/s41467-023-38457-x
Fusion of the molecular adjuvant C3d to cleavage-independent native-like HIV-1 Env trimers improves the elicited antibody response
Authors: Shridhar Bale, Lifei Yang, Mehrdad Alirezaei, Richard Wilson, Takayuki Ota, Esmeralda D Doyle, Christopher A Cottrell, Javier Guenaga, Karen Tran, Wenjuan Li, Leonidas Stamatatos, David Nemazee, Andrew B Ward, Richard T Wyatt
Journal: Front Immunol
PubMed ID: 37283743
Doi: 10.3389/fimmu.2023.1180959
CFTR and dystrophin encoding plasmids carrying both luciferase reporter gene, nuclear import specific sequences and triple helix sites
Authors: Delphine Maze, Caroline Girardin, Nathalie Benz, Tristan Montier, Chantal Pichon, Patrick Midoux
Journal: Plasmid
PubMed ID: 37207938
Doi: 10.1016/j.plasmid.2023.102686
Inflammation Modifies miR-21 Expression Within Neuronal Extracellular Vesicles to Regulate Remyelination Following Spinal Cord Injury
Authors: Tianyu Han, Peiwen Song, Zuomeng Wu, Yunlei Liu, Wang Ying, Cailiang Shen
Journal: Stem Cell Rev Rep
PubMed ID: 37256514
Doi: 10.1007/s12015-023-10560-y
Products & Services: Gene Synthesis   
Predictive data-driven modeling of C-terminal tyrosine function in the EGFR signaling network
Authors: Jacqueline S Gerritsen, Joseph S Faraguna, Rudy Bonavia, Frank B Furnari, Forest M White
Journal: Life Sci Alliance
PubMed ID: 37169593
Doi: 10.26508/lsa.202201466
Products & Services: Stable Cell Lines   
Deep sampling of gRNA in the human genome and deep-learning-informed prediction of gRNA activities
Authors: Heng Zhang, Jianfeng Yan, Zhike Lu, Yangfan Zhou, Qingfeng Zhang, Tingting Cui, Yini Li, Hui Chen, Lijia Ma
Journal: Cell Discov
PubMed ID: 37193681
Doi: 10.1038/s41421-023-00549-9
Products & Services: Gene Synthesis   
Simultaneous enhancement of multiple functional properties using evolution-informed protein design
Authors: Benjamin Fram, Ian Truebridge, Yang Su, Adam J Riesselman, John B Ingraham, Alessandro Passera, Eve Napier, Nicole N Thadani, Samuel Lim, Kristen Roberts, Gurleen Kaur, Michael Stiffler, Debora S Marks, Christopher D Bahl, Amir R Khan, Chris Sander, Nicholas P Gauthier
Journal: biorxiv
PubMed ID: 37214973
Doi: 10.1101/2023.05.09.539914
Products & Services: Molecular Biology Reagents   
Preparation of magnetic polyacrylamide hydrogel with chitosan for immobilization of glutamate decarboxylase to produce γ-aminobutyric acid
Authors: Jianjun Wang, Luyao Wang, Chengli Yang, Yihui Zhu, Ziqian Chen, Guanya He, Kaishun Hu, Kaixuan Liu, Beibei Fang, Dali Li, Ruofu Shi
Journal: Prep Biochem Biotechnol
PubMed ID: 37184437
Doi: 10.1080/10826068.2023.2209884
Reticular adhesions are assembled at flat clathrin lattices and opposed by active integrin α5β1
Authors: Laura Hakanpää, Amr Abouelezz, An-Sofie Lenaerts, Seyda Culfa, Michael Algie, Jenny Bärlund, Pekka Katajisto, Harvey McMahon, Leonardo Almeida-Souza
Journal: J Cell Biol
PubMed ID: 37233325
Doi: 10.1083/jcb.202303107
Arabidopsis calmodulin-like proteins CML13 and CML14 interact with proteins that have IQ domains
Authors: Howard J Teresinski, Bryan Hau, Kyle Symonds, Ryan Kilburn, Kim A Munro, Nathan M Doner, Robert Mullen, Vivian H Li, Wayne A Snedden
Journal: Plant Cell Environ
PubMed ID: 37222394
Doi: 10.1111/pce.14616
Products & Services: Catalog Antibody   
Fortuitous somatic mutations during antibody evolution endow broad neutralization against SARS-CoV-2 Omicron variants
Authors: Jianbo Wu, Zhenguo Chen, Yidan Gao, Zegen Wang, Jiarong Wang, Bing-Yu Chiang, Yunjiao Zhou, Yuru Han, Wuqiang Zhan, Minxiang Xie, Weiyu Jiang, Xiang Zhang, Aihua Hao, Anqi Xia, Jiaying He, Song Xue, Christian T Mayer, Fan Wu, Bin Wang, Lunan Zhang, Lei Sun, Qiao Wang
Journal: Cell Rep
PubMed ID: 37178120
Doi: 10.1016/j.celrep.2023.112503
Products & Services: Catalog Peptides   
Design and application of artificial rare L-lysine codons in Corynebacterium glutamicum
Authors: Cuiping Yang , Zehao Peng , Lu Yang , Bowen Du , Chuanzhuang Guo , Songsen Sui , Jianbin Wang , Junlin Li , Junqing Wang , Nan Li
Journal: Front Bioeng Biotechnol
PubMed ID: 7324439
Doi: 10.3389/fbioe.2023.1194511
Products & Services: Gene Synthesis   
JNK3 Overexpression in the Entorhinal Cortex Impacts on the Hippocampus and Induces Cognitive Deficiencies and Tau Misfolding
Authors: Carlos G Ardanaz, Amaia Ezkurdia, Arantza Bejarano, Beatriz Echarte, Cristian Smerdou, Eva Martisova, Iván Martínez-Valbuena, María-Rosario Luquin, María J Ramírez, Maite Solas
Journal: ACS Chem Neurosci
PubMed ID: 37236204
Doi: 10.1021/acschemneuro.3c00092
CLASPs stabilize the pre-catastrophe intermediate state between microtubule growth and shrinkage
Authors: Elizabeth J Lawrence, Saptarshi Chatterjee, Marija Zanic
Journal: J Cell Biol
PubMed ID: 37184584
Doi: 10.1083/jcb.202107027
Alpha-synuclein-associated changes in PINK1-PRKN-mediated mitophagy are disease context dependent
Authors: Xu Hou, Taylor Hsuan-Yu Chen, Shunsuke Koga, Jenny M Bredenberg, Ayman H Faroqi, Marion Delenclos, Guojun Bu, Zbigniew K Wszolek, Jonathan A Carr, Owen A Ross, Pamela J McLean, Melissa E Murray, Dennis W Dickson, Fabienne C Fiesel, Wolfdieter Springer
Journal: Brain Pathol
PubMed ID: 37259617
Doi: 10.1111/bpa.13175
Single point mutations at the S129 residue of α-synuclein and their effect on structure, aggregation, and neurotoxicity
Authors: Esha Pandit, Lopamudra Das, Anoy Kumar Das, Sandip Dolui, Saumen Saha, Uttam Pal, Animesh Mondal, Joydeep Chowdhury, Subhas C Biswas, Nakul C Maiti
Journal: Front Chem
PubMed ID: 37304685
Doi: 10.3389/fchem.2023.1145877
Massively parallel evaluation and computational prediction of the activities and specificities of 17 small Cas9s
Authors: Sang-Yeon Seo, Seonwoo Min, Sungtae Lee, Jung Hwa Seo, Jinman Park, Hui Kwon Kim, Myungjae Song, Dawoon Baek, Sung-Rae Cho, Hyongbum Henry Kim
Journal: Nat Methods
PubMed ID: 37188955
Doi: 10.1038/s41592-023-01875-2
Products & Services: Molecular Biology Reagents   
The effects of free Cys residues on the structure, activity, and tetrameric stability of mammalian uricase
Authors: Yong Guo, Jingjing Huo, Runchao Bai, Jingyuan Zhang, Jipeng Yao, Kaijie Ma, Zengtao Zhang, Haigang Li, Chun Zhang
Journal: Appl Microbiol Biotechnol
PubMed ID: 37256327
Doi: 10.1007/s00253-023-12597-y
Products & Services: Molecular Biology Reagents   
Functional characterization of novel or yet uncharacterized ATP7B missense variants detected in patients with clinical Wilson's disease
Authors: Amelie Stalke, Annika Behrendt, Finja Hennig, Holger Gohlke, Nicole Buhl, Thea Reinkens, Ulrich Baumann, Brigitte Schlegelberger, Thomas Illig, Eva-Doreen Pfister, Britta Skawran
Journal: Clin Genet
PubMed ID: 37157876
Doi: 10.1111/cge.14352
Products & Services: Gene Synthesis   
Bre1/RNF20 promotes Rad51-mediated strand exchange and antagonizes the Srs2/FBH1 helicases
Authors: Guangxue Liu, Jimin Li, Boxue He, Jiaqi Yan, Jingyu Zhao, Xuejie Wang, Xiaocong Zhao, Jingyan Xu, Yeyao Wu, Simin Zhang, Xiaoli Gan, Chun Zhou, Xiangpan Li, Xinghua Zhang, Xuefeng Chen
Journal: Nat Commun
PubMed ID: 37230987
Doi: 10.1038/s41467-023-38617-z
Products & Services: Recombinant Proteins   
Resin and loading condition screening for effective and robust byproducts removal by anion exchange chromatography: A case study
Authors: Wei Chen, Peter K Wang, Chien-Chun Liao, Yifeng Li, Yan Wan
Journal: Protein Expr Purif
PubMed ID: 37209930
Doi: 10.1016/j.pep.2023.106297
Efficient precise integration of large DNA sequences with 3′-overhang dsDNA donors using CRISPR/Cas9
Authors: Wenjie Han, Zhigang Li, Yijun Guo, Kaining He, Wenqing Li, Caoling Xu, Lishuang Ge, Miao He, Xue Yin, Junxiang Zhou, Chengxu Li, Dongbao Yao, Jianqiang Bao, Haojun Liang
Journal: Proceedings of the national academy of sciences of the USA
PubMed ID: 37216515
Doi: 10.1073/pnas.2221127120
Products & Services: CRISPR RNAs/Cas9 Proteins(INACTIVE)   
Computational engineering of previously crystallized pyruvate formate-lyase activating enzyme reveals insights into SAM binding and reductive cleavage
Authors: James D Moody, Sarah Hill, Maike N Lundahl, Aubrianna J Saxton, Amanda Galambas, William E Broderick, C Martin Lawrence, Joan B Broderick
Journal: J Biol Chem
PubMed ID: 37156396
Doi: 10.1016/j.jbc.2023.104791
Full-length versus truncated α-factor secretory signal sequences for expression of recombinant human insulin precursor in yeast Pichia pastoris: a comparison
Authors: Nuruliawaty Utami, Dini Nurdiani, Hariyatun Hariyatun, Eko Wahyu Putro, Fadillah Putri Patria, Wien Kusharyoto
Journal: J Genet Eng Biotechnol
PubMed ID: 37212962
Doi: 10.1186/s43141-023-00521-w
A glycan receptor kinase facilitates intracellular accommodation of arbuscular mycorrhiza and symbiotic rhizobia in the legume Lotus japonicus
Authors: Simon Kelly, Simon B Hansen, Henriette Rübsam, Pia Saake, Emil B Pedersen, Kira Gysel, Eva Madland, Shunliang Wu, Stephan Wawra, Dugald Reid, John T Sullivan, Zuzana Blahovska, Maria Vinther, Artur Muszynski, Parastoo Azadi, Mikkel B Thygesen, Finn L Aachmann, Clive W Ronson, Alga Zuccaro, Kasper R Andersen, Simona Radutoiu, Jens Stougaard
Journal: PLoS Biol
PubMed ID: 37200394
Doi: 10.1371/journal.pbio.3002127
Multiplexed Gene Engineering Based on dCas9 and gRNA-tRNA Array Encoded on Single Transcript
Authors: Chaoqian Jiang, Lishuang Geng, Jinpeng Wang, Yingjuan Liang, Xiaochen Guo, Chang Liu, Yunjing Zhao, Junxue Jin, Zhonghua Liu, Yanshuang Mu
Journal: Int J Mol Sci
PubMed ID: 37239880
Doi: 10.3390/ijms24108535
Structural basis of epitope selectivity and potent protection from malaria by PfCSP antibody L9
Authors: Gregory M Martin, Monica L Fernández-Quintero, Wen-Hsin Lee, Tossapol Pholcharee, Lisa Eshun-Wilson, Klaus R Liedl, Marie Pancera, Robert A Seder, Ian A Wilson, Andrew B Ward
Journal: Nat Commun
PubMed ID: 37198165
Doi: 10.1038/s41467-023-38509-2
Products & Services: Codon Optimization   
An efficient transformation method for genome editing of elite bread wheat cultivars
Authors: Akshaya K Biswal, L Ruben B Hernandez, Ana I R Castillo, Juan M Debernardi, Kanwarpal S Dhugga
Journal: Front Plant Sci
PubMed ID: 37275249
Doi: 10.3389/fpls.2023.1135047
Products & Services: Custom DNA/RNA Oligos   
L-Lactate treatment by photosynthetic cyanobacteria expressing heterogeneous L-lactate dehydrogenase
Authors: Yuichi Kato, Kosuke Inabe, Yuji Haraguchi, Tatsuya Shimizu, Akihiko Kondo, Tomohisa Hasunuma
Journal: Sci Rep
PubMed ID: 37142758
Doi: 10.1038/s41598-023-34289-3
Products & Services: Gene Synthesis   

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