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Visualizing the impact of disease-associated mutations on G protein-nucleotide interactions

Authors: Kara Anazia, Lucien Koenekoop, Guillaume Ferré, Enzo Petracco, Hugo Gutiérrez-de-Teran, Matthew T Eddy

Journal: biorxiv

PubMed ID: 38352316

Doi: 10.1101/2024.01.30.578006

Products & Services: PCR Cloning and Subcloning

Stalled translation by mitochondrial stress upregulates a CNOT4-ZNF598 ribosomal quality control pathway important for tissue homeostasis

Authors: Ji Geng, Shuangxi Li, Yu Li, Zhihao Wu, Sunil Bhurtel, Suman Rimal, Danish Khan, Rani Ohja, Onn Brandman, Bingwei Lu

Journal: Nat Commun

PubMed ID: 38388640

Doi: 10.1038/s41467-024-45525-3

Products & Services: Molecular Biology Reagents

A mRNA Vaccine for Crimean-Congo Hemorrhagic Fever Virus Expressing Non-Fusion GnGc Using NSm Linker Elicits Unexpected Immune Responses in Mice

Authors: Tong Chen, Zhe Ding, Xuejie Li, Yingwen Li, Jiaming Lan, Gary Wong

Journal: Viruses

PubMed ID: 38543744

Doi: 10.3390/v16030378

Products & Services: Molecular Biology Reagents

Activation of CBASS Cap5 endonuclease immune effector by cyclic nucleotides

Authors: Olga Rechkoblit, Daniela Sciaky, Dale F Kreitler, Angeliki Buku, Jithesh Kottur, Aneel K Aggarwal

Journal: Nat Struct Mol Biol

PubMed ID: 38321146

Doi: 10.1038/s41594-024-01220-x

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Differential functional consequences of GRIN2A mutations associated with schizophrenia and neurodevelopmental disorders

Authors: Nate Shepard, David Baez-Nieto, Sumaiya Iqbal, Erkin Kurganov, Nikita Budnik, Arthur J Campbell, Jen Q Pan, Morgan Sheng, Zohreh Farsi

Journal: Sci Rep

PubMed ID: 38307912

Doi: 10.1038/s41598-024-53102-3

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Recurrent evolutionary switches of mitochondrial cytochrome c maturation systems in Archaeplastida

Authors: Huang Li, Soujanya Akella, Carina Engstler, Joy J Omini, Moira Rodriguez, Toshihiro Obata, Chris Carrie, Heriberto Cerutti, Jeffrey P Mower

Journal: Nat Commun

PubMed ID: 38378784

Doi: 10.1038/s41467-024-45813-y

Products & Services: Molecular Biology Reagents

Unraveling the Catalytic Mechanism of Taxadiene-5α-hydroxylase from Crystallography and Computational Analyses

Authors: Xitong Song, Qian Wang, Xiaoxi Zhu, Wenhan Fang, Xiaonan Liu, Chao Shi, Zhenzhan Chang, Huifeng Jiang, and Binju Wang

Journal: ACS Catal

Doi: doi.org/10.1021/acscatal.3c05807

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Covalent bicyclization of protein complexes yields durable quaternary structures

Authors: George H Hutchins, Sebastian Kiehstaller, Pascal Poc, Abigail H Lewis, Jisun Oh, Raya Sadighi, Nicholas M Pearce, Mohamed Ibrahim, Ivana Drienovská, Anouk M Rijs, Saskia Neubacher, Sven Hennig, Tom N Grossmann

Journal: Chem

PubMed ID: 38344167

Doi: 10.1016/j.chempr.2023.10.003

Products & Services: Protein and Antibody Isolation

Neuroprotective effects of annexin A1 tripeptide in rats with sepsis-associated encephalopathy

Authors: Qiao Cui, Nannan Qin, Yonghan Zhang, Yanmei Miao, Leiyu Xie, Xinglong Ma, Zhiquan Zhang, Peng Xie

Journal: Biotechnol Appl Biochem

PubMed ID: 38409880

Doi: 10.1002/bab.2569

Products & Services: Peptide Synthesis

CircUSP1 as a novel marker promotes gastric cancer progression via stabilizing HuR to upregulate USP1 and Vimentin

Authors: Rong Li, Junyi Wang, Zhenfan Xie, Xinyu Tian, Jie Hou, Dongli Wang, Hui Qian, Han Shen, Wenrong Xu

Journal: Oncogene

PubMed ID: 38366146

Doi: 10.1038/s41388-024-02968-8

Products & Services: Molecular Biology Reagents

Conservation of Affinity Rather Than Sequence Underlies a Dynamic Evolution of the Motif-Mediated p53/MDM2 Interaction in Ray-Finned Fishes

Authors: Filip Mihalič, Dahiana Arcila, Mats E Pettersson, Pouria Farkhondehkish, Eva Andersson, Leif Andersson, Ricardo Betancur-R, Per Jemth

Journal: Mol Biol Evol

PubMed ID: 38301272

Doi: 10.1093/molbev/msae018

Products & Services: Protein and Antibody Isolation

Human sequences form R-loop structures

Authors: Agata M Parsons, Kemin Su, Maya Daniels, Gerrit J Bouma, Gregory B Vanden Heuvel, Erik D Larson

Journal: MicroPubl Biol

PubMed ID: 38371318

Doi: 10.17912/micropub.biology.001058

Products & Services: Gene Synthesis

Tandem repeats of highly bioluminescent NanoLuc are refolded noncanonically by the Hsp70 machinery

Authors: Dimitra Apostolidou, Pan Zhang, Devanshi Pandya, Kaden Bock, Qinglian Liu, Weitao Yang, Piotr E Marszalek

Journal: Protein Sci

PubMed ID: 38284490

Doi: 10.1002/pro.4895

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The exposure to glyphosate on the integrity of intestinal epithelial tight junctions of chicks

Authors: Mohamed A Fathi, Dan Shen, Lu Luo, Yansen Li, Shaaban S Elnesr, Chunmei Li

Journal: J Environ Sci Health B

PubMed ID: 38400726

Doi: 10.1080/03601234.2024.2319006

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Lianhua Qingke Preserves Mucociliary Clearance in Rat with Acute Exacerbation of Chronic Obstructive Pulmonary Disease by Maintaining Ciliated Cells Proportion and Protecting Structural Integrity and Beat Function of Cilia

Authors: Xiaoqi Wang, Yuanjie Hao, Yujie Yin, Yunlong Hou, Ningxin Han, Yi Liu, Zhen Li, Yaru Wei, Kun Ma, Jiaojiao Gu, Yan Ma, Hui Qi, Zhenhua Jia

Journal: Int J Chron Obstruct Pulmon Dis

PubMed ID: 38343495

Doi: 10.2147/COPD.S436323

Products & Services: Protein and Antibody Isolation

A SARS-CoV-2 RBD vaccine fused to the chemokine MIP-3α elicits sustained murine antibody responses over 12 months and enhanced lung T-cell responses

Authors: James Tristan Gordy, Yinan Hui, Courtney Schill, Tianyin Wang, Fengyixin Chen, Kaitlyn Fessler, Jacob Meza, Yangchen Li, Alannah D Taylor, Rowan E Bates, Petros C Karakousis, Andrew Pekosz, Jaiprasath Sachithanandham, Maggie Li, Styliani Karanika, Richard B Markham

Journal: Front Immunol

PubMed ID: 38370404

Doi: 10.3389/fimmu.2024.1292059

Products & Services: Molecular Biology Reagents

Supramolecular Synthons in Protein-Ligand Frameworks

Authors: Ronan J Flood, Niamh M Mockler, Aurélien Thureau, Maura Malinska, Peter B Crowley

Journal: Cryst Growth Des

PubMed ID: 38463617

Doi: 10.1021/acs.cgd.3c01480

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Structure of the WYL-domain containing transcription activator, DriD, in complex with ssDNA effector and DNA target site

Authors: Maria A Schumacher, Emily Cannistraci, Raul Salinas, Devin Lloyd, Ella Messner, Kevin Gozzi

Journal: Nucleic Acids Res

PubMed ID: 38142455

Doi: 10.1093/nar/gkad1198

Products & Services: Mutant Libraries

A Modified Tridecapeptide Probe for Imaging Cell Junction

Authors: Jingrui Li, Yuhan Wu, Chunyu Liu, Shu Zhang, Xin Su, Songbo Xie, Fengtang Yang

Journal: Molecules

PubMed ID: 38474514

Doi: 10.3390/molecules29051003

Products & Services: Catalog Peptides

Effects of polyphenol and gelatin types on the physicochemical properties and emulsion stabilization of polyphenol-crosslinked gelatin conjugates

Authors: Wenjuan Wu, Cuiping Shi, Ye Zi, Huan Gong, Lijia Chen, Guangyi Kan, Xichang Wang, Jian Zhong

Journal: Food Chem X

PubMed ID: 38440057

Doi: 10.1016/j.fochx.2024.101250

Products & Services: Protein Electrophoresis and Western

Gene-edited triple mutant Medicago plants do not flower

Authors: Axel Poulet, Min Zhao, Yongyan Peng, FangFei Tham, Mauren Jaudal, Lulu Zhang, Josien C van Wolfswinkel, Joanna Putterill

Journal: Front Plant Sci

PubMed ID: 38469328

Doi: 10.3389/fpls.2024.1357924

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Role of aminopeptidase N-like in the acquisition of begomoviruses by Bemisia tabaci, the whitefly vector

Authors: Yun-Yun Fan, Yao Chi, Na Chen, Wilmer J Cuellar, Xiao-Wei Wang

Journal: Insect Sci

PubMed ID: 38369384

Doi: 10.1111/1744-7917.13336

Products & Services: Catalog Peptides

PeptiVAX: A new adaptable peptides-delivery platform for development of CTL-based, SARS-CoV-2 vaccines

Authors: Sara Feola, Jacopo Chiaro, Manlio Fusciello, Salvatore Russo, Iivari Kleino, Leena Ylösmäki, Eliisa Kekäläinen, Johanna Hästbacka, Pirkka T Pekkarinen, Erkko Ylösmäki, Stefania Capone, Antonella Folgori, Angelo Raggioli, Carolina Boni, Camilla Tiezzi, Andrea Vecchi, Monica Gelzo, Hassen Kared, Alessandra Nardin, Michael Fehlings, Veronique Barban, Petra Ahokas, Tapani Viitala, Giuseppe Castaldo, Lucio Pastore, Paul Porter, Sari Pesonen, Vincenzo Cerullo

Journal: Int J Biol Macromol

PubMed ID: 38331062

Doi: 10.1016/j.ijbiomac.2024.129926

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In vitro evolution of diagnostic antibodies targeting native antigens in plasma by sandwich flow cytometry

Authors: Mingxia Liang, Fanlei Ran, Li Li, Haiying Hang, Lili An

Journal: Biotechnol J

PubMed ID: 38403438

Doi: 10.1002/biot.202300492

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Photoactivatable CRISPR/Cas12a Sensors for Biomarkers Imaging and Point-of-Care Diagnostics

Authors: Qing-Nan Li, Dong-Xia Wang, Dan-Ye Chen, Jia-Ao Lyu, Ya-Xin Wang, Shun-Li Wu, Hong-Xin Jiang, De-Ming Kong

Journal: Anal Chem

PubMed ID: 38305871

Doi: 10.1021/acs.analchem.3c05497

Products & Services: Custom DNA/RNA Oligos

Chagasin from Trypanosoma cruzi as a molecular scaffold to express epitopes of TSA-1 as soluble recombinant chimeras

Authors: Rosa Elena Cárdenas-Guerra, Octavio Montes-Flores, Edgar Ezequiel Nava-Pintor, Gerardo Reséndiz-Cardiel, Claudia Ivonne Flores-Pucheta, Yasmín Irene Rodríguez-Gavaldón, Rossana Arroyo, Maria Elena Bottazzi, Peter J Hotez, Jaime Ortega-López

Journal: Protein Expr Purif

PubMed ID: 38423156

Doi: 10.1016/j.pep.2024.106458

Products & Services: Codon Optimization

Systematic Engineering of for Efficient Production of Cytidine 5'-Monophosphate

Authors: Min Zhou, Liyuan Wei, Chongzhi Wu, Wei Chen, Zhengju Tang

Journal: ACS Omega

PubMed ID: 38371780

Doi: 10.1021/acsomega.3c07713

Products & Services: Custom DNA/RNA Oligos

Antibodies toward Na,HCO-cotransporter NBCn1/SLC4A7 block net acid extrusion and cause pH-dependent growth inhibition and apoptosis in breast cancer

Authors: Trine V Axelsen, Claus Olesen, Danish Khan, Ali Mohammadi, Elena V Bouzinova, Christine J F Nielsen, Marco Mele, Katrine R Hauerslev, Helene L Pedersen, Eva Balling, Pernille Vahl, Trine Tramm, Peer M Christiansen, Ebbe Boedtkjer

Journal: Br J Cancer

PubMed ID: 38310186

Doi: 10.1038/s41416-024-02591-0

Products & Services: Catalog Antibodies

UPP1 promotes lung adenocarcinoma progression through the induction of an immunosuppressive microenvironment

Authors: Yin Li, Manling Jiang, Ling Aye, Li Luo, Yong Zhang, Fengkai Xu, Yongqi Wei, Dan Peng, Xiang He, Jie Gu, Xiaofang Yu, Guoping Li, Di Ge, Chunlai Lu

Journal: Nat Commun .

PubMed ID: 38331898

Doi: 10.1038/s41467-024-45340-w

Products & Services: Protein and Antibody Isolation

Cepharanthine analogs mining and genomes of Stephania accelerate anti-coronavirus drug discovery

Authors: Liang Leng, Zhichao Xu, Bixia Hong, Binbin Zhao, Ya Tian, Can Wang, Lulu Yang, Zhongmei Zou, Lingyu Li, Ke Liu, Wanjun Peng, Jiangning Liu, Zhoujie An, Yalin Wang, Baozhong Duan, Zhigang Hu, Chuan Zheng, Sanyin Zhang, Xiaodong Li, Maochen Li, Zhaoyu Liu, Zenghao Bi, Tianxing He, Baimei Liu, Huahao Fan, Chi Song, Yigang Tong, Shilin Chen

Journal: Nat Commun .

PubMed ID: 38378731

Doi: 10.1038/s41467-024-45690-5

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Characterization of N-glycosylation and its Functional Role in SIDT1-Mediated RNA Uptake

Authors: Tingting Yang, Haonan Xiao, Xiulan Chen, Le Zheng, Hangtian Guo, Jiaqi Wang, Xiaohong Jiang, Chen-Yu Zhang, Fuquan Yang, Xiaoyun Ji

Journal: J Biol Chem

PubMed ID: 38237680

Doi: 10.1016/j.jbc.2024.105654

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The CRL5–SPSB3 ubiquitin ligase targets nuclear cGAS for degradation

Authors: Pengbiao Xu , Ying Liu , Chong Liu , Baptiste Guey , Lingyun Li , Pauline Melenec , Jonathan Ricci , Andrea Ablasser

Journal: Nature

PubMed ID: 38418882

Doi: 10.1038/s41586-024-07112-w

Products & Services: Antibody Modification and Purification Services

The CARD8 inflammasome dictates HIV/SIV pathogenesis and disease progression

Authors: Qiankun Wang, Kolin M Clark, Ritudhwaj Tiwari, Nagarajan Raju, Gregory K Tharp, Jeffrey Rogers, R Alan Harris, Muthuswamy Raveendran, Steven E Bosinger, Tricia H Burdo, Guido Silvestri, Liang Shan

Journal: Cell

PubMed ID: 38428396

Doi: 10.1016/j.cell.2024.01.048

Products & Services: Gene Synthesis

Molecular dissection of an intronic enhancer governing cold-induced expression of the vacuolar invertase gene in potato

Authors: Xiaobiao Zhu , Airu Chen, Nathaniel M Butler, Zixian Zeng, Haoyang Xin , Lixia Wang , Zhaoyan Lv, Dani Eshel, David S Douches, Jiming Jiang

Journal: Cell

PubMed ID: 38374801

Doi: 10.1093/plcell/koae050

Products & Services: Gene Synthesis

Insertion of a FLAG-tag sequence at the end of exon 9 of the TBX5 gene in three induced pluripotent stem cell lines (DHMi004-A-4, DHMi004-A-5, DHMi004-A-6) by CRISPR/Cas9 technology

Authors: Harald Lahm, Niraj K Singh, Irina Gottmann, Stefanie A Doppler, Elda Dzilic, Heike Preisler, Stephanie Schneider, Rüdiger Lange, Markus Krane, Martina Dreßen

Journal: Cell Research

PubMed ID: 38100916

Doi: 10.1016/j.scr.2023.103261

Products & Services: Plasmid DNA Preparation

Carotenoid cleavage enzymes evolved convergently to generate the visual chromophore

Authors: Yasmeen J Solano , Michael P Everett , Kelly S Dang , Jude Abueg , Philip D Kiser

Journal: Nature Chemical Biology

PubMed ID: 38355721

Doi: 10.1038/s41589-024-01554-z

Products & Services: Plasmid DNA Preparation

mTOR Regulates Mineralocorticoid Receptor Transcriptional Activity by ULK1-Dependent and -Independent Mechanisms

Authors: Yusuf Ali, Celso E Gomez-Sanchez, Maria Plonczynski, Aniko Naray-Fejes-Toth, Geza Fejes-Toth, Elise P Gomez-Sanchez

Journal: Endocrinology

PubMed ID: 38325289

Doi: 10.1210/endocr/bqae015

Products & Services: Protein and Antibody Isolation

Exploring the immunogenicity of Rv2201-519: A T-cell epitope-based antigen derived from Mycobacterium tuberculosis AsnB with implications for tuberculosis infection detection and vaccine development

Authors: Xiuli Luan, Xueting Fan, Guilian Li, Mchao Li, Na Li, Yuhan Yan, Xiuqin Zhao, Haican Liu, Kanglin Wan

Journal: Int Immunopharmacol

PubMed ID: 38342063

Doi: 10.1016/j.intimp.2024.111542

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Discovery of Two Novel Immunoepitopes and Development of Peptide-based Sarcoidosis Immunoassay

Authors: Changya Peng , Jaya Talreja , Brennen Steinbauer , Kazuhiko Shinki , Laura L Koth , Lobelia Samavati

Journal: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

PubMed ID: 38385694

Doi: 10.1164/rccm.202306-1054OC

Products & Services: Peptide Synthesis Polyclonal Antibody Services

Bile salt hydrolase catalyses formation of amine-conjugated bile acids

Authors: Bipin Rimal, Stephanie L Collins, Ceylan E Tanes, Edson R Rocha, Megan A Granda, Sumeet Solanki, Nushrat J Hoque, Emily C Gentry, Imhoi Koo, Erin R Reilly, Fuhua Hao, Devendra Paudel, Vishal Singh 11, Tingting Yan 12, Min Soo Kim 2, Kyle Bittinger 3, Joseph P Zackular 13 14, Kristopher W Krausz 12, Dhimant Desai 15, Shantu Amin 15, James P Coleman 4, Yatrik M Shah 5, Jordan E Bisanz 2 16, Frank J Gonzalez 12, John P Vanden Heuvel 1 17, Gary D Wu 18, Babette S Zemel 3, Pieter C Dorrestein 7 8, Emily E Weinert 2 6, Andrew D Patterson 19 20 21

Journal: Nature

PubMed ID: 38326609

Doi: 10.1038/s41586-023-06990-w

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Harnessing eukaryotic retroelement proteins for transgene insertion into human safe-harbor loci

Authors: Xiaozhu Zhang, Briana Van Treeck, Connor A. Horton, Jeremy J. R. McIntyre, Sarah M. Palm, Justin L. Shumate & Kathleen Collins

Journal: Nat Biotechnol

PubMed ID: 38379101

Doi: 10.1038/s41587-024-02137-y

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Disordered regions mediate the interaction of p53 and MRE11

Authors: Sinem Usluer , Markus Galhuber , Yukti Khanna , Benjamin Bourgeois , Emil Spreitzer , Helene Michenthaler, Andreas Prokesch, Tobias Madl

Journal: Cell Research

PubMed ID: 38123020

Doi: 10.1016/j.bbamcr.2023.119654

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Biomimetic bacteria-derived nanoclusters enhance ferroptosis cancer immunotherapy through synergistic CRISPR-photothermo modulation

Authors: Xiuhua Pan , Jie Yang , Ruixin Kang , Jun Zhang , Zongwei Hu , Ning Yang , Zengyi Liu , Zengguang Jia , Xiawei Zhou , Qi Shen

Journal: Nano Today

Doi: 10.1016/j.nantod.2024.102213

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Comprehensive Genomic Analysis Identifies a Diverse Landscape of Sideroblastic and Nonsideroblastic Iron-Related Anemias with Novel and Pathogenic Variants in an Iron-Deficient Endemic Setting

Authors: Pankaj Sharma, Prateek Bhatia, Minu Singh, Manu Jamwal, Swetha Pallavelangini, Reena Das, Pankaj Malhotra, Savita V Attri, Sarah Ducamp, Mark D Fleming, Amita Trehan

Journal: J Mol Diagn

PubMed ID: 38360212

Doi: 10.1016/j.jmoldx.2024.01.011

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Stromal interaction molecule 1/microtubule-associated protein 1A/1B-light chain 3B complex induces metastasis of hepatocellular carcinoma by promoting autophagy

Authors: Jingchun Wang, Qichao Xie, Lei Wu, Yu Zhou, Yanquan Xu, Yu Chen, Jiangang Zhang, Ran Ren, Shiming Yang, Yongsheng Li, Huakan Zhao

Journal: MedComm (2020)

PubMed ID: 38344399

Doi: 10.1002/mco2.482

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A bioluminescent and homogeneous assay for monitoring GPCR-mediated cAMP modulation and PDE activity

Authors: Dareen Mikheil, Matthew A Larsen, Kevin Hsiao, Nathan H Murray, Tim Ugo, Hui Wang, Said A Goueli

Journal: Sci Rep

PubMed ID: 38396287

Doi: 10.1038/s41598-024-55038-0

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Gonococcal OMV-delivered PorB induces epithelial cell mitophagy

Authors: Shuai Gao, Lingyu Gao, Dailin Yuan, Xu'ai Lin, Stijn van der Veen

Journal: Nat Commun

PubMed ID: 38396029

Doi: 10.1038/s41467-024-45961-1

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SARS-CoV-2 targets ribosomal RNA biogenesis

Authors: V Talya Yerlici, Audrey Astori, Nevraj S Kejiou, Chris A Jordan, Negin Khosraviani, Janet N Y Chan, Razqallah Hakem, Brian Raught, Alexander F Palazzo, Karim Mekhail

Journal: Cell Rep

PubMed ID: 38427561

Doi: 10.1016/j.celrep.2024.113891

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Shrimp injection with dsRNA targeting the microsporidian EHP polar tube protein reduces internal and external parasite amplification

Authors: Satika Yuanlae, Tharinthon Prasartset, Onrapak Reamtong, Natthinee Munkongwongsiri, Muthita Panphloi, Thanchanok Preechakul, Rungkarn Suebsing, Siripong Thitamadee, Anuphap Prachumwat, Ornchuma Itsathitphaisarn, Suparat Taengchaiyaphum, Chanadda Kasamechotchung

Journal: Sci Rep

PubMed ID: 38413745

Doi: 10.1038/s41598-024-55400-2

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Engineering recombinant replication-competent bluetongue viruses expressing reporter genes for and non-invasive studies

Authors: Sergio Utrilla-Trigo, Luis Jiménez-Cabello, Alejandro Marín-López, Miguel Illescas-Amo, Germán Andrés, Eva Calvo-Pinilla, Gema Lorenzo, Piet A van Rijn, Javier Ortego, Aitor Nogales

Journal: Microbiol Spectr

PubMed ID: 38353566

Doi: 10.1128/spectrum.02493-23

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