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Shank3 ameliorates neuronal injury after cerebral ischemia/reperfusion via inhibiting oxidative stress and inflammation

Authors: Hongchen Zhang, Yuan Feng, Yanfang Si, Chuanhao Lu, Juan Wang, Shiquan Wang, Liang Li, Wenyu Xie, Zheming Yue, Jia Yong, Shuhui Dai, Lei Zhang, Xia Li

Journal: Redox Biol

PubMed ID: 38064762

Doi: 10.1016/j.redox.2023.102983

Products & Services: Protein and Antibody Isolation

Overlapping characteristics of weak interactions of two transcriptional regulators with WDR5

Authors: Mohammad Ahmad, Ali Imran, Liviu Movileanu

Journal: Int J Biol Macromol

PubMed ID: 38158065

Doi: 10.1016/j.ijbiomac.2023.128969

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Anti-inflammatory effects of neuregulin-1 in HaCaT keratinocytes and atopic dermatitis-like mice stimulated with Der p 38

Authors: Jeong Hee Yun, Yujin Hong, Min Hwa Hong, Geunyeong Kim, Ji-Sook Lee, Ran-Sook Woo, Juram Lee, Eun Ju Yang, In Sik Kim

Journal: Cytokine

PubMed ID: 38134557

Doi: 10.1016/j.cyto.2023.156439

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Bivalent inhibitors of the BTB E3 ligase KEAP1 enable instant NRF2 activation to suppress acute inflammatory response

Authors: Mengchen Lu, Jianai Ji, Yifei Lv, Jing Zhao, Yuting Liu, Qiong Jiao, Tian Liu, Yi Mou, Qidong You, Zhengyu Jiang

Journal: Cell Chem Biol

PubMed ID: 38157852

Doi: 10.1016/j.chembiol.2023.12.005

Products & Services: PCR Cloning and Subcloning

Screening of novel DPP-IV inhibitory peptides derived from bovine milk proteins using a peptide array platform

Authors: Sayuri Arai, Masaki Kurimoto, Hajime Nakada, Masayoshi Tanaka, Hiroshi Ochi, Miyuki Tanaka, Mina Okochi

Journal: J Biosci Bioeng

PubMed ID: 38092600

Doi: 10.1016/j.jbiosc.2023.11.007

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Template and target-site recognition by human LINE-1 in retrotransposition

Authors: Akanksha Thawani, Alfredo Jose Florez Ariza, Eva Nogales, Kathleen Collins

Journal: Nature

PubMed ID: 38096901

Doi: 10.1038/s41586-023-06933-5

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Convergent evolution of SARS-CoV-2 XBB lineages on receptor-binding domain 455-456 synergistically enhances antibody evasion and ACE2 binding

Authors: Fanchong Jian, Leilei Feng, Sijie Yang, Yuanling Yu, Lei Wang, Weiliang Song, Ayijiang Yisimayi, Xiaosu Chen, Yanli Xu, Peng Wang, Lingling Yu, Jing Wang, Lu Liu, Xiao Niu, Jing Wang, Tianhe Xiao, Ran An, Yao Wang, Qingqing Gu, Fei Shao, Ronghua Jin, Zhongyang Shen, Youchun Wang, Xiangxi Wang, Yunlong Cao

Journal: PLoS Pathog

PubMed ID: 38117863

Doi: 10.1371/journal.ppat.1011868

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Plant-based meat analogues enhance the gastrointestinal motility function and appetite of mice by specific volatile compounds and peptides

Authors: Yunting Xie, Linlin Cai, Mengzhen Ding, Kai Shan, Di Zhao, Guanghong Zhou, Chunbao Li

Journal: Food Research International

Doi: 10.1016/j.foodres.2023.113551

Products & Services: Gene Synthesis

Biguanide chitosan microneedles with cell-free DNA scavenging ability for psoriasis therapy

Authors: Zihao Liu , Yu Wang , Yuhan Zhang , Liufu Hu , Bozhi Chen , Yang Li , Xindong Guo , Bingran Yu , Fu-Jian Xu

Journal: Bioactive Materials

Doi: 10.1016/j.bioactmat.2023.11.015

Products & Services: Gene Synthesis

Synthetic High-Density Lipoprotein-Based Nanomedicine to Silence SOCS1 in Tumor Microenvironment and Trigger Antitumor Immunity against Glioma

Authors: Chunrong Yang , Yujie Li , Yuchen Yang , Qiankun Ni , Zeyu Zhang , Yi Chai , Jinghong Li

Journal: Angew Chem Int Ed Engl .

PubMed ID: 37847126

Doi: 10.1002/anie.202312603

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A KDPG sensor RccR governs Pseudomonas aeruginosa carbon metabolism and aminoglycoside antibiotic tolerance

Authors: Yujue Wang , Zhipeng Wang , Weizhong Chen , Ze-Hui Ren , Hui Gao , Jiani Dai , Guan-Zheng Luo , Zhaowei Wu , Quanjiang Ji

Journal: Nucleic Acids Res .

PubMed ID: 38096062

Doi: 10.1093/nar/gkad1201

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Shenqi Fuzheng injection restores the sensitivity to gefitinib in non-small cell lung cancer by inhibiting the IL-22 STAT3 AKT pathway

Authors: Jiali Wang , Xianhai He , Zhirong Jia , Aiwen Yan , Kang Xiao , Shuo Liu , Mengjun Hou , Yaling Long , Xuansheng Ding

Journal: Pharm Biol .

PubMed ID: 38100532

Doi: 10.1080/13880209.2023.2292266

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Structure and mechanism of a eukaryotic ceramide synthase complex

Authors: Tian Xie , Qi Fang , Zike Zhang , Yanfei Wang , Feitong Dong , Xin Gong

Journal: EMBO J .

PubMed ID: 37953642

Doi: 10.15252/embj.2023114889

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The nuclease-associated short prokaryotic Argonaute system nonspecifically degrades DNA upon activation by target recognition

Authors: Xueling Lu, Jun Xiao, Longfei Wang, Bin Zhu, Fengtao Huang

Journal: Nucleic Acids Res

PubMed ID: 38048327

Doi: 10.1093/nar/gkad1145

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Authors: Ewa Hordyjewska-Kowalczyk, Wim Wuyts, Nele Boeckx, An Verdonck, Gretl Hendrickx, Geert Mortier

Journal: Clin Genet

PubMed ID: 38108099

Doi: 10.1111/cge.14474

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Differential activation of mouse and human Panx1 channel variants

Authors: Antonio Cibelli, Preeti Dohare, David C Spray, Eliana Scemes

Journal: PLoS ONE

PubMed ID: 38100403

Doi: 10.1371/journal.pone.0295710

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A randomized phase II study of acyclovir for the prevention of chemotherapy-induced oral mucositis in patients undergoing autologous hematopoietic stem cell transplantation

Authors: Junshik Hong, Hee-Kyung Park, Sung-Ho Chang, Ja Min Byun, Dong-Yeop Shin, Youngil Koh, Sung-Soo Yoon, Youngnim Choi, Inho Kim

Journal: BMC Oral Health

PubMed ID: 38102638

Doi: 10.1186/s12903-023-03623-6

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The global transcription regulator XooClp governs Type IV pili system mediated bacterial virulence by directly binding to their promoters to coordinate virulence associated functions

Authors: Raj Kumar Verma, Parimala Gondu, Tirthankar Saha, Subhadeep Chatterjee

Journal: Mol Plant Microbe Interact

PubMed ID: 38105438

Doi: 10.1094/MPMI-07-23-0100-R

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Characterizations of a neutralizing antibody broadly reactive to multiple gluten peptide:HLA-DQ25 complexes in the context of celiac disease

Authors: Yuu Okura, Yuri Ikawa-Teranishi, Akihiko Mizoroki, Noriyuki Takahashi, Takashi Tsushima, Machiko Irie, Zulkarnain Harfuddin, Momoko Miura-Okuda, Shunsuke Ito, Genki Nakamura, Hiroaki Takesue, Yui Ozono, Masamichi Nishihara, Kenta Yamada, Siok Wan Gan, Akira Hayasaka, Shinya Ishii, Tetsuya Wakabayashi, Masaru Muraoka, Nishiki Nagaya, Hiroshi Hino, Takayuki Nemoto, Taichi Kuramochi, Takuya Torizawa, Hideaki Shimada, Takehisa Kitazawa, Makoto Okazaki, Junichi Nezu, Ludvig M Sollid, Tomoyuki Igawa

Journal: Nat Commun

PubMed ID: 38135691

Doi: 10.1038/s41467-023-44083-4

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ALOX5 deficiency contributes to bladder cancer progression by mediating ferroptosis escape

Authors: Tianyao Liu, Xinyan Xu, Jiazheng Li, Ming Bai, Wenjie Zhu, Yanqing Liu, Siyang Liu, Zihan Zhao, Tianhang Li, Ning Jiang, Yuhao Bai, Qingyang Jin, Yulin Zhang, Yufeng Zheng, Shengkai Zhou, Shoubin Zhan, Ying Sun, Gaoli Liang, Yang Luo, Xi Chen, Hongqian Guo, Rong Yang

Journal: Cell Death Dis

PubMed ID: 38062004

Doi: 10.1038/s41419-023-06333-7

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Acid phosphatase-like proteins, a biogenic amine and leukotriene-binding salivary protein family from the flea Xenopsylla cheopis

Authors: Stephen Lu, John F Andersen, Christopher F Bosio, B Joseph Hinnebusch, José M Ribeiro

Journal: Commun Biol

PubMed ID: 38110569

Doi: 10.1038/s42003-023-05679-0

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Bioinformatics analyses of infiltrating immune cell participation on pancreatic ductal adenocarcinoma progression and in vivo experiment of the therapeutic effect of Shuangshen granules

Authors: Jiaqi Hu, Juling Jiang, Bowen Xu, Yue Li, Bei Wang, Shulin He, Xiaoling Ren, Bolun Shi, Xing Zhang, Honggang Zheng, Baojin Hua, Rui Liu

Journal: J Ethnopharmacol

PubMed ID: 38113986

Doi: 10.1016/j.jep.2023.117590

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Uncovering elevated tau TPP motif phosphorylation in the brain of Alzheimer's disease patients

Authors: Jean-Pierre Bellier, Yuqi Cai, Sarah M Alam, Thorsten Wiederhold, Arica Aiello, Jonathan S Vogelgsang, Sabina Berretta, Jasmeer P Chhatwal, Dennis J Selkoe, Lei Liu

Journal: Alzheimers Dement

PubMed ID: 38041855

Doi: 10.1002/alz.13557

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Protocol for precision editing of endogenous Chlamydomonas reinhardtii genes with CRISPR-Cas

Authors: Adrian Pascal Nievergelt, Dennis Ray Diener, Aliona Bogdanova, Thomas Brown, Gaia Pigino

Journal: STAR Protoc

PubMed ID: 38096061

Doi: 10.1016/j.xpro.2023.102774

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Agonistic Bivalent Human scFvs-Fcγ Fusion Antibodies to OX40 Ectodomain Enhance T Cell Activities against Cancer

Authors: Kodchakorn Mahasongkram, Kantaphon Glab-Ampai, Kanasap Kaewchim, Thanatsaran Saenlom, Monrat Chulanetra, Nitat Sookrung, Oytip Nathalang, Wanpen Chaicumpa

Journal: Vaccines (Basel)

PubMed ID: 38140230

Doi: 10.3390/vaccines11121826

Products & Services: Recombinant Proteins

Base editing of the HBG promoter induces potent fetal hemoglobin expression with no detectable off-target mutations in human HSCs

Authors: Wenyan Han, Hou-Yuan Qiu, Shangwu Sun, Zhi-Can Fu, Guo-Quan Wang, Xiaowen Qian, Lijie Wang, Xiaowen Zhai, Jia Wei, Yichuan Wang, Yi-Lin Guo, Guo-Hua Cao, Rui-Jin Ji, Yi-Zhou Zhang, Hongxia Ma, Hongsheng Wang, Mingli Zhao

Journal: Cell Stem Cell

PubMed ID: 37989316

Doi: 10.1016/j.stem.2023.10.007

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A plasmid containing the human metallothionein-II gene selectively distinguishes trivalent lanthanum from several divalent heavy metal cations during monoclonal antibody-assisted agarose gel electrophoresis

Authors:

Journal: Toxicol Ind Health

PubMed ID: 38095284

Doi: 10.1177/07482337231222354

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Glucose-primed PEEK orthopedic implants for antibacterial therapy and safeguarding diabetic osseointegration

Authors: Miaomiao He, Hao Wang, Qiuyang Han, Xiuyuan Shi, Shuai He, Jiyu Sun, Zhuoli Zhu, Xueqi Gan, Yi Deng

Journal: Biomaterials

PubMed ID: 37948855

Doi: 10.1016/j.biomaterials.2023.122355

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Neuroprotective Effects of N-methyl-(2S, 4R)-trans-4-hydroxy-L-proline (NMP) against Amyloid-β-Induced Alzheimer's Disease Mouse Model

Authors: Jawad Ali, Amjad Khan, Jun Sung Park, Muhammad Tahir, Waqas Ahmad, Kyonghwan Choe, Myeong Ok Kim

Journal: Nutrients

PubMed ID: 38068844

Doi: 10.3390/nu15234986

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Infliximab aggregates produced in severe and mild elevated temperature stress conditions induce an extended specific CD4 T-cell response

Authors: Myriam Nabhan, Sylvain Meunier, Victor Le-Minh, Baptiste Robin, Marie de Bourayne, Claire Smadja, Bernard Maillère, Marc Pallardy, Isabelle Turbica

Journal: Eur J Pharm Sci

PubMed ID: 38070782

Doi: 10.1016/j.ejps.2023.106670

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A bead-based multiplex assay covering all coronaviruses pathogenic for humans for sensitive and specific surveillance of SARS-CoV-2 humoral immunity

Authors: Daniel Stern, Tanja C Meyer, Fridolin Treindl, Hans Werner Mages, Maren Krüger, Martin Skiba, Jan Philipp Krüger, Christian M Zobel, Maximilian Schreiner, Marica Grossegesse, Thomas Rinner, Caroline Peine, Anna Stoliaroff-Pépin, Thomas Harder, Natalie Hofmann, Janine Michel, Andreas Nitsche, Silke Stahlberg, Antje Kneuer, Anna Sandoni, Ulrike Kubisch, Martin Schlaud, Annette Mankertz, Tatjana Schwarz, Victor M Corman, Marcel A Müller, Christian Drosten, Kathrin de la Rosa, Lars Schaade, Martin B Dorner, Brigitte G Dorner

Journal: Sci Rep

PubMed ID: 38071261

Doi: 10.1038/s41598-023-48581-9

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Gene-based COVID-19 vaccines: Australian perspectives in a corporate and global context

Authors: Peter Rhodes, Peter Parry

Journal: Pathol Res Pract

PubMed ID: 38101158

Doi: 10.1016/j.prp.2023.155030

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Engineered hydrogel reveals contribution of matrix mechanics to esophageal adenocarcinoma and identifies matrix-activated therapeutic targets

Authors: Ricardo Cruz-Acuña, Secunda W Kariuki, Kensuke Sugiura, Spyros Karaiskos, Eleanor M Plaster, Claudia Loebel, Gizem Efe, Tatiana Karakasheva, Joel T Gabre, Jianhua Hu, Jason A Burdick, Anil K Rustgi

Journal: J Clin Invest

PubMed ID: 37788109

Doi: 10.1172/JCI168146

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α-Synuclein emulsifies TDP-43 prion-like domain-RNA liquid droplets to promote heterotypic amyloid fibrils

Authors: Shailendra Dhakal, Malay Mondal, Azin Mirzazadeh, Siddhartha Banerjee, Ayanjeet Ghosh, Vijayaraghavan Rangachari

Journal: Commun Biol

PubMed ID: 38052886

Doi: 10.1038/s42003-023-05608-1

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Redeveloping antigen detection kits for the diagnosis of rat hepatitis E virus

Authors: Zihao Chen, Guanghui Li, Jianwen Situ, Zhiyong Li, Shaoqi Guo, Yang Huang, Shusheng Wu, Zimin Tang, Guiping Wen, Siling Wang, Mujin Fang, Yingbin Wang, Hai Yu, Siddharth Sridhar, Zizheng Zheng, Ningshao Xia

Journal: J Clin Microbiol

PubMed ID: 38038482

Doi: 10.1128/jcm.00710-23

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An evolutionarily conserved serine protease network mediates melanization and Toll activation in

Authors: Tisheng Shan, Yang Wang, Krishna Bhattarai, Haobo Jiang

Journal: Sci Adv

PubMed ID: 38117884

Doi: 10.1126/sciadv.adk2756

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Mezigdomide is effective alone and in combination with Menin inhibition in pre-clinical models of KMT2A-r and NPM1c AML

Authors: Wallace Bourgeois, Jevon A Cutler, Brandon J Aubrey, Daniela Wenge, Florian Perner, Cynthia Martucci, Jill A Henrich, Kelly Klega, Radoslaw P Nowak, Katherine Aleisha Donovan, Meaghan Boileau, Yanhe Wen, Charles Hatton, Athina A Apazidis, Sarah N Olsen, Nadia Kirmani, Yana Pikman, Jessica A Pollard, Jennifer A Perry, Adam S Sperling, Benjamin L Ebert, Gerard M McGeehan, Brian D Crompton, Eric S Fischer, Scott A Armstrong

Journal: Blood

PubMed ID: 38096371

Doi: 10.1182/blood.2023021105

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The OsBZR1-OsSPX1/2 Module Fine-tunes Growth-Immunity Trade-off in Adaptation to Pi Availability in Rice

Authors: Yuqing He , Yao Zhao , Jitao Hu , Lanlan Wang , Linying Li , Xueying Zhang , Zhongjing Zhou , Lili Chen , Hua Wang , Jiaoyu Wang , Gaojie Hong

Journal: Mol Plant .

PubMed ID: 38069474

Doi: 10.1016/j.molp.2023.12.003

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Anti-virulence and bactericidal activities of Stattic against Shigella sonnei

Authors: Mingfang Wang, Jia Zeng, Huihui Tan, Quan Guo, Xia Li, Xiwen Ling, Jinyue Zhang, Shihao Song, Yinyue Deng

Journal: Appl Environ Microbiol .

PubMed ID: 38032177

Doi: 10.1128/aem.01074-23

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Emerging variants of SARS-CoV-2 NSP10 highlight strong functional conservation of its binding to two non-structural proteins, NSP14 and NSP16

Authors: Huan Wang, Syed R A Rizvi, Danni Dong, Jiaqi Lou, Qian Wang, Watanyoo Sopipong, Yufeng Su, Fares Najar, Pratul K Agarwal, Frank Kozielski, Shozeb Haider

Journal: Elife

PubMed ID: 38127066

Doi: 10.7554/eLife.87884

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Activation and characterization of G protein-coupled receptors for CHHs in the mud crab, Scylla paramamosain

Authors: Nan Mo, Shucheng Shao, Yan Zhuang, Yanan Yang, Zhaoxia Cui, Chenchang Bao

Journal: Comp Biochem Physiol A Mol Integr Physiol

PubMed ID: 38122925

Doi: 10.1016/j.cbpa.2023.111563

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Efficient de novo production of bioactive cordycepin by Aspergillus oryzae using a food-grade expression platform

Authors: Sukanya Jeennor, Jutamas Anantayanon, Sarocha Panchanawaporn, Chanikul Chutrakul, Wanwipa Vongsangnak, Kobkul Laoteng

Journal: Microb Cell Fact

PubMed ID: 38071331

Doi: 10.1186/s12934-023-02261-5

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Diverse nature of ClpX degradation motifs in

Authors: Vivek Gurung, Saswati Biswas, Indranil Biswas

Journal: Microbiol Spectr

PubMed ID: 38051052

Doi: 10.1128/spectrum.03457-23

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Immunogenicity Persistence of a Third-Dose Homologous BBIBP-CorV/CoronaVac Boosting Vaccination: A Prospective Open-Label Study

Authors: Na Ren, Zhihong Wang, Sikang Gao

Journal: Viral Immunol

PubMed ID: 38109058

Doi: 10.1089/vim.2023.0075

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The egg ribonuclease SjCP1412 accelerates liver fibrosis caused by infection involving damage-associated molecular patterns (DAMPs)

Authors: Qi-Feng Li, Yi-Xin Li, Ying-Ying Yang, Pan-Pan Dong, Cong-Jin Mei, Ju-Lu Lu, Jian-Feng Zhang, Hai-Yong Hua, Chun-Rong Xiong, Chuan-Xin Yu, Li-Jun Song, Kun Yang

Journal: Parasitology

PubMed ID: 38105713

Doi: 10.1017/S0031182023001361

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Worsening of imiquimod-induced psoriasiform inflammation in mice by environmental pollutant, di-(2-ethylhexyl) phthalate through dysregulation in IL-17A and Nrf2/iNOS signaling in peripheral myeloid and CD4 + T cells

Authors: Ali S Alfardan, Ahmed Nadeem, Sheikh F Ahmad, Naif O Al-Harbi, Mohammed Alqinyah, Sabry M Attia, Wedad Sarawi, Ahmed Z Alanazi, Khalid Alhazzani, Khalid E Ibrahim

Journal: Int Immunopharmacol

PubMed ID: 38056199

Doi: 10.1016/j.intimp.2023.111293

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Pro-osteogenic role of interleukin-22 in calcific aortic valve disease

Authors: Huifang Deng, Huadong Li, Zongtao Liu, Na Shen, Nianguo Dong, Cheng Deng, Fayuan Liu

Journal: Atherosclerosis

PubMed ID: 38104486

Doi: 10.1016/j.atherosclerosis.2023.117424

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Resveratrol-derived inhibitors of the E3 ubiquitin ligase PELI1 inhibit the metastasis of triple-negative breast cancer

Authors: Guangsen Xu, Qian Zhou, Jie Qi, Zhongyue Li, Lijun Yin, Zhuoran Li, Chunhua Lu, Baobing Zhao, Yuemao Shen

Journal: Eur J Med Chem

PubMed ID: 38150964

Doi: 10.1016/j.ejmech.2023.116060

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The density of anionic lipids modulates the adsorption of α-Synuclein onto lipid membranes

Authors: Alexandra Andersson, Sara Linse, Emma Sparr, Marco Fornasier, Peter Jönsson

Journal: Biophys Chem

PubMed ID: 38100855

Doi: 10.1016/j.bpc.2023.107143

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Metabolic signatures of tear extracellular vesicles caused by herpes simplex keratitis

Authors: Huixiang Ma, Tucan Chen, Chengxu Li, Hao Xu, Qingyu Feng, Yunfei Su, Jianqiu Cai, Qingfu Zhu, Fei Liu, Liang Hu

Journal: Ocul Surf

PubMed ID: 38122863

Doi: 10.1016/j.jtos.2023.12.005

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