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PP2A and GSK3 act as modifiers of FUS-ALS by modulating mitochondrial transport

Authors: Paraskevi Tziortzouda , Jolien Steyaert , Wendy Scheveneels , Adria Sicart , Katarina Stoklund Dittlau , Adriana Margarida Barbosa Correia , Thibaut Burg , Arun Pal , Andreas Hermann , Philip Van Damme , Thomas G Moens , Ludo Van Den Bosch

Journal: Acta Neuropathol

PubMed ID: 38363426

Doi: 10.1007/s00401-024-02689-y

Products & Services: Peptide Synthesis

Characterization of NAC Gene Family in and Functional Analysis of , an Osmotic and Cold-Stress-Induced NAC Gene

Authors: Tashi Dorjee, Yican Cui, Yuxin Zhang, Qi Liu, Xuting Li, Batu Sumbur, Hongxi Yan, Jie Bing, Yuke Geng, Yijun Zhou, Fei Gao

Journal: Biomolecules

PubMed ID: 38397419

Doi: 10.3390/biom14020182

Products & Services: Catalog Peptides

Production and Immunogenicity Assessment of LTp50: An -Made Chimeric Antigen Targeting S1- and S2-Epitopes from the SARS-CoV-2/BA5 Spike Protein

Authors: Alejandra Wong-Arce, Omar Gonzalez-Ortega, Andrea Romero-Maldonado, Arleth Miranda-López, Mariano García-Soto, Susan Farfán-Castro, Lourdes Betancourt-Mendiola, Samaporn Teeravechyan, Kanjana Srisutthisamphan, Mauricio Comas-García, Karla I Solís Andrade, Sergio Rosales-Mendoza

Journal: Pharmaceuticals (Basel)

PubMed ID: 38543088

Doi: 10.3390/ph17030302

Products & Services: Protein and Antibody Isolation

Seroprevalence of Anti-SARS-CoV-2 Antibodies in Cats during Five Waves of COVID-19 Epidemic in Thailand and Correlation with Human Outbreaks

Authors: Suporn Thongyuan, Jeeraphong Thanongsaksrikul, Potjanee Srimanote, Wallaya Phongphaew, Piyaporn Eiamcharoen, Naris Thengchaisri, Angela Bosco-Lauth, Nicola Decaro, Rungrueang Yodsheewan

Journal: Animals (Basel)

PubMed ID: 38473145

Doi: 10.3390/ani14050761

Products & Services: Molecular Biology Reagents

Nitrogen-Doped Carbon Dots Facilitate CRISPR/Cas for Reducing Antibiotic Resistance Genes in the Environment

Authors: Feiran Chen, Hao Du, Mengna Tao, Lanqing Xu, Chuanxi Wang, Jason C White, Zhenyu Wang, Baoshan Xing

Journal: J Agric Food Chem

PubMed ID: 38335532

Doi: 10.1021/acs.jafc.3c08558

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Characterization of antibodies targeting severe fever with thrombocytopenia syndrome virus glycoprotein Gc

Authors: Kaori Sano, Miyuki Kimura, Akiko Sataka, Hideki Hasegawa, Hideki Tani, Tadaki Suzuki

Journal: Arch Virol

PubMed ID: 38308735

Doi: 10.1007/s00705-024-05968-x

Products & Services: Protein and Antibody Isolation

A Pseudovirus-Based Neutralization Assay for SARS-CoV-2 Variants: A Rapid, Cost-Effective, BSL-2-Based High-Throughput Assay Useful for Vaccine Immunogenicity Evaluation

Authors: Zhaohui Cai, Raj Kalkeri, Mingzhu Zhu, Shane Cloney-Clark, Benjamin Haner, Mi Wang, Bahar Osman, Dominic Dent, Sheau-Line Feng, Zach Longacre, Greg Glenn, Joyce S Plested

Journal: Microorganisms

PubMed ID: 38543552

Doi: 10.3390/microorganisms12030501

Products & Services: Codon Optimization

Primary vulvar adenocarcinoma of intestinal type: Report of two cases showing molecular similarity with colorectal adenocarcinoma

Authors: Claudia Mateoiu, Andrea Palicelli, Thais Maloberti, Dario De Biase, Antonio De Leo, Magnus Lindh, Katja Stenström Bohlin, Simona Stolnicu

Journal: Pathol Res Pract

PubMed ID: 38340583

Doi: 10.1016/j.prp.2024.155181

Products & Services: Molecular Biology Reagents

Lymph Node-Targeted Vaccine Boosting of TCR T-cell Therapy Enhances Antitumor Function and Eradicates Solid Tumors

Authors: Dylan J Drakes, Abdulraouf M Abbas, Jacqueline Shields, Martin P Steinbuck, Aniela Jakubowski, Lochana M Seenappa, Christopher M Haqq, Peter C DeMuth

Journal: Cancer Immunol Res

PubMed ID: 38270373

Doi: 10.1158/2326-6066.CIR-22-0978

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Chimeric nanobody-decorated liposomes by self-assembly

Authors: Md Mofizur Rahman, Jing Wang, Guosheng Wang, Zhipeng Su, Yizeng Li, Yundi Chen, Jinguo Meng, Yao Yao, Lefei Wang, Stephan Wilkens, Jifu Tan, Juntao Luo, Tao Zhang, Chuandong Zhu, Sung Hyun Cho, Lixue Wang, Luke P Lee, Yuan Wan

Journal: Nat Nanotechnol

PubMed ID: 38374413

Doi: 10.1038/s41565-024-01620-6

Products & Services: Recombinant Proteins

Impact of sex on humoral immunity with live influenza B virus vaccines in mice

Authors: Stivalis Cardenas-Garcia, C Joaquín Cáceres, Aarti Jain, Ginger Geiger, Jong-Suk Mo, L Claire Gay, Brittany Seibert, Algimantas Jasinskas, Rie Nakajima, Daniela S Rajao, D Huw Davies, Daniel R Perez

Journal: npj Vaccines

PubMed ID: 38409236

Doi: 10.1038/s41541-024-00827-x

Products & Services: Molecular Biology Reagents

Direct observation of autoubiquitination for an integral membrane ubiquitin ligase in ERAD

Authors: Basila Moochickal Assainar, Kaushik Ragunathan, Ryan D Baldridge

Journal: Nat Commun

PubMed ID: 38351109

Doi: 10.1038/s41467-024-45541-3

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Nanofibrous MultiDomain Peptide Hydrogels Provide T Cells a 3D, Cytocompatible Environment for Cell Expansion and Antigen-Specific Killing

Authors: Viridiana Leyva-Aranda, Shailbala Singh, Maria J Telesforo, Simon Young, Cassian Yee, Jeffrey D Hartgerink

Journal: ACS Biomater Sci Eng

PubMed ID: 38385283

Doi: 10.1021/acsbiomaterials.3c01617

Products & Services: Protein and Antibody Isolation

The B. subtilis replicative polymerases bind the sliding clamp with different strengths to tune replication processivity and fidelity

Authors: Luke G. O Neal; Madeline N. Drucker; Ngoc Khanh Lai; Ashley F. Clemente; Alyssa P. Campbell; Lindsey E. Way; Sinwoo Hong; Emily E. Holmes; Sarah J. Rancic; Nicholas Sawyer; Xindan Wang; Elizabeth S. Thrall

Journal: biorxiv

PubMed ID: 40161823

Doi: 10.1101/2025.03.10.642433

The B. subtilis replicative polymerases bind the sliding clamp with different strengths to tune replication processivity and fidelity

Journal: biorxiv

PubMed ID: 40161823

Doi: 10.1101/2025.03.10.642433

Single dose of a recombinant vesicular stomatitis virus-based vaccine elicits robust and durable neutralizing antibody response against Hantaan virus

Authors: Hui Zhang, He Liu , Jing Wei , Yamei Dang , Yuan Wang , Qiqi Yang , Liang Zhang , Chuantao Ye , Bin Wang , Xiaolei Jin , Linfeng Cheng , Hongwei Ma , Yangchao Dong , Yinghui Li , Yinlan Bai , Xin Lv , Yingfeng Lei , Zhikai Xu , Wei Ye , Fanglin Zhang

Journal: NPJ Vaccines .

PubMed ID: 38341504

Doi: 10.1038/s41541-024-00814-2

Products & Services: Gene Synthesis

Unveiling the structural mechanisms of nonpeptide ligand recognition and activation in human chemokine receptor CCR8

Authors: Shan Jiang , Xi Lin , Lijie Wu , Ling Wang , Yiran Wu , Ziyi Xu , Fei Xu

Journal: Sci Adv .

PubMed ID: 38306437

Doi: 10.1126/sciadv.adj7500

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ECSIT facilitates memory CD8+ T cell development by mediating fumarate synthesis during viral infection and tumorigenesis

Authors: Yongbing Yang , Yanan Wang , Zhongcheng Wang , Huanyu Yan , Yi Gong , Yingchao Hu , Yuying Jiang , Shuang Wen , Feifei Xu , Bingwei Wang , Fiachra Humphries , Yun Chen , Xi Wang , Shuo Yang

Journal: Nat Cell Biol .

PubMed ID: 38326554

Doi: 10.1038/s41556-024-01351-9

Products & Services: Peptide Synthesis

An Enzyme-Cleavable Solubilizing-Tag Facilitates the Chemical Synthesis of Mirror-Image Protein

Authors: Yupeng Zheng, Baochang Zhang , Wei-Wei Shi, Xiangyu Deng, Tong-Yue Wang, Dongyang Han, Yuxiang Ren, Ziyi Yang, Yong-Kang Zhou, Jian Kuang, Zhi-Wen Wang, Shan Tang, Ji-Shen Zheng

Journal: Angew Chem Int Ed Engl .

PubMed ID: 38326236

Doi: 10.1002/ange.202318897

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Prediction of anticancer peptides derived from the true lectins of Phoenix dactylifera and their synergetic effect with mitotane

Authors: Othman Baothman, Ehab M. M. Ali , Salman Hosawi , Emadeldin Hassan E. Konoz, Isam M. Abu Zeid, Abrar Ahmadand Hisham N. Altayb

Journal: Frontiers in pharmacology

Doi: 10.3389/fphar.2024.1322865

Products & Services: Peptide Synthesis

Molecular mechanism of human ISG20L2 for the ITS1 clea vag e in the processing of 18S precursor ribosomal RNA

Authors: Yinliang Ma, Jiaxu Wang, Xingyi He, Yuhang Liu, Shuo Zhen, Lina An, Qian Yang, Fumin Niu, Hong Wang, Boran An, Xinyue Tai, Zhenzhen Yan, Chen Wu, Xiaoyun Yang, Xiuhua Liu

Journal: Nucleic Acids Res

PubMed ID: 38153123

Doi: 10.1093/nar/gkad1210

Products & Services: Gene Synthesis

Ribosomal collision is not a prerequisite for ZNF598-mediated ribosome ubiquitination and disassembly of ribosomal complexes by ASCC

Authors: Anna Miścicka, Alexander G Bulakhov, Kazushige Kuroha, Alexandra Zinoviev, Christopher U T Hellen, Tatyana V Pestova

Journal: Nucleic Acids Res

PubMed ID: 38366554

Doi: 10.1093/nar/gkae087

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GDI2 deletion alleviates neurodegeneration and memory loss in the 5xFAD mice model of Alzheimer's disease

Authors: Meitian Wang, Xiuqing He, Jie Li, Daobin Han, Pan You, Hui Yu, Luwen Wang, Bo Su

Journal: Biochim Biophys Acta Mol Basis Dis

PubMed ID: 38382624

Doi: 10.1016/j.bbadis.2024.167093

Products & Services: Peptide Synthesis

Cryo-EM structures of the plant plastid-encoded RNA polymerase

Authors: Xiao-Xian Wu, Wen-Hui Mu, Fan Li, Shu-Yi Sun, Chao-Jun Cui , Chanhong Kim, Fei Zhou , Yu Zhang

Journal: Cell

PubMed ID: 38428393

Doi: 10.1016/j.cell.2024.01.026

Products & Services: Peptide Synthesis

High-Level Biosynthesis of Chlorogenic Acid from Mixed Carbon Sources of Xylose and Glucose through a Rationally Refactored Pathway Network

Authors: Yuhui Wang, Haining Tan, Yanling Wang, Jing Liang Qin, Xinyu Zhao, Yuhan Di, Lijie Xie, Xiaojing Zhao, Ziyu Li, Guozhen Ma, Lingyan Jiang, Bin Liu, Di Huang

Journal: J Agric Food Chem

PubMed ID: 38330270

Doi: 10.1021/acs.jafc.3c08587

Products & Services: Molecular Biology Reagents

Voltage-gated ion channels are expressed in the Malpighian tubules and anal papillae of the yellow fever mosquito (Aedes aegypti), and may regulate ion transport during salt and water imbalance

Authors: Serena Farrell, Jocelyne Dates, Nancy Ramirez, Hannah Hausknecht-Buss, Dennis Kolosov

Journal: J Exp Biol

PubMed ID: 38197515

Doi: 10.1242/jeb.246486

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A novel ex vivo assay to evaluate functional effectiveness of Plasmodium vivax transmission blocking vaccine using Pvs25 transgenic P. berghei

Authors: Yi Cao, Clifford T H Hayashi, Nirbhay Kumar

Journal: J Infect Dis

PubMed ID: 38408353

Doi: 10.1093/infdis/jiae102

Products & Services: Gene Synthesis

A model of human neural networks reveals NPTX2 pathology in ALS and FTLD

Authors: Marian Hruska-Plochan, Vera I Wiersma, Katharina M Betz, Izaskun Mallona, Silvia Ronchi, Zuzanna Maniecka, Eva-Maria Hock, Elena Tantardini, Florent Laferriere, Sonu Sahadevan, Vanessa Hoop, Igor Delvendahl, Manuela Pérez-Berlanga, Beatrice Gatta, Martina Panatta, Alexander van der Bourg, Dasa Bohaciakova, Puneet Sharma , Laura De Vos, Karl Frontzek , Adriano Aguzzi, Tammaryn Lashley , Mark D Robinson, Theofanis Karayannis, Martin Mueller, Andreas Hierlemann 4, Magdalini Polymenidou 13

Journal: Nature

PubMed ID: 38355792

Doi: 10.1038/s41586-024-07042-7

Products & Services: Gene Synthesis

HIV coinfection exacerbates HBV-induced liver fibrogenesis through a HIF-1α- and TGF-β1-dependent pathway

Authors: Min Xu , Charlotte Warner, Xiaoqiong Duan, Zhimeng Cheng, Andre J Jeyarajan, Wenting Li, Yongtao Wang , Tuo Shao , Shadi Salloum , Pei-Jer Chen , Xu Yu , Raymond T Chung , Wenyu Lin

Journal: J Hepatol

PubMed ID: 38311121

Doi: 10.1016/j.jhep.2024.01.026

Products & Services: Gene Synthesis

Integrating network pharmacology and experimental models to identify notoginsenoside R1 ameliorates atherosclerosis by inhibiting macrophage NLRP3 inflammasome activation

Authors: Jingyue Yu, Jinyu Hu, Margaret Baldini, Huan Lei, Lei Li, Shanshan Luo, Jielian Wu, Xupin Liu, Dan Shan, Yanfei Xie, Haihong Fang, Jun Yu

Journal: J Nat Med

PubMed ID: 38409483

Doi: 10.1007/s11418-023-01776-w

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Therapeutic potential of exosome derived from hepatocyte growth factor-overexpressing adipose mesenchymal stem cells in TGFβ1-stimulated hepatic stellate cells

Authors: Jin Wang, Weikang Ye, Ming Jiang, Yinong Zhou, Jie Zheng

Journal: Cytotechnology

PubMed ID: 38495297

Doi: 10.1007/s10616-023-00611-0

Products & Services: Molecular Biology Reagents

Pharmacologic Characterization of LTGO-33, a Selective Small Molecule Inhibitor of the Voltage-Gated Sodium Channel Na18 with a Unique Mechanism of Action

Authors: John M Gilchrist, Nien-Du Yang, Victoria Jiang, Bryan D Moyer

Journal: Mol Pharmacol

PubMed ID: 38195157

Doi: 10.1124/molpharm.123.000789

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Inhibition of AMPK activation in sensu stricto limits the parasite's glucose metabolism and survival

Authors: Mingzhi Yan, Hui Liu, Yansen Su, Xiaojuan Bi, Ning Yang, Renyong Lin, Guodong Lü

Journal: Antimicrob Agents Chemother

PubMed ID: 38349157

Doi: 10.1128/aac.01202-23

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The ETI-dependent receptor-like kinase 1 positively regulates effector-triggered immunity by stabilizing NLR-required for cell death 4 in Nicotiana benthamiana

Authors: Yujing Sun, Fan Liu, Mengzhu Zeng, Xinjie Zhang, Ying Cui, Zhaodan Chen, Lei Wang, Yuanpeng Xu, Jinbin Wu, Shengya Guo, Xian Dong, Suomeng Dong, Yan Wang, Yuanchao Wang

Journal: New Phytol

PubMed ID: 38362937

Doi: 10.1111/nph.19596

Products & Services: DNA Sequencing

Membrane-Associated Ubiquitin Ligase RING Finger Protein 152 Orchestrates Melanogenesis via Tyrosinase Ubiquitination

Authors: Ryota Ueda, Rina Hashimoto, Yuki Fujii, José C J M D S Menezes, Hirotaka Takahashi, Hiroyuki Takeda, Tatsuya Sawasaki, Tomonori Motokawa, Kenzo Tokunaga, Hideaki Fujita

Journal: Membranes (Basel)

PubMed ID: 38392670

Doi: 10.3390/membranes14020043

Nanobody-Mediated Dualsteric Engagement of the Angiotensin Receptor Broadens Biased Ligand Pharmacology

Authors: Nayara Braga Emidio , Brandi M Small , Amanda R Keller , Ross W Cheloha , Laura M Wingler

Journal: Mol Pharmacol

PubMed ID: 38164609

Doi: 10.1124/molpharm.123.000797

Products & Services: Peptide Synthesis

Newcastle disease virus regulates its replication by instigating oxidative stress-driven Sirtuin 7 production

Authors: Kamal Shokeen, Sachin Kumar

Journal: J Gen Virol

PubMed ID: 38376490

Doi: 10.1099/jgv.0.001961

Products & Services: Gene Synthesis

Filamin A Is a Prognostic Serum Biomarker for Differentiating Benign Prostatic Hyperplasia from Prostate Cancer in Caucasian and African American Men

Authors: Nischal Mahaveer Chand, Poornima K Tekumalla, Matt T Rosenberg, Albert Dobi, Amina Ali, Gregory M Miller, Juan J Aristizabal-Henao, Elder Granger, Stephen J Freedland, Mark D Kellogg, Shiv Srivastava, David G McLeod, Niven R Narain, Michael A Kiebish

Journal: Cancers (Basel)

PubMed ID: 38398103

Doi: 10.3390/cancers16040712

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Safety and immunogenicity of CoronaVac in healthy adults: A prospective observational multicenter real-world study in Henan Province, China

Authors: Benchen Rao, Ling Wang, Mengzhao Yang, Hong Luo, Junyi Sun, Shanshuo Liu, Haiyu Wang, Xuemei Wang, Lei Li, Chengyu Yuan, Zujiang Yu, Zhigang Ren

Journal: Virulence

PubMed ID: 38326274

Doi: 10.1080/21505594.2024.2310450

Products & Services: Molecular Biology Reagents

DNA polymerase iota promotes EMT and metastasis of esophageal squamous cell carcinoma by interacting with USP7 to stabilize HIF-1α

Authors: Aidi Gao, Mingxia Zhang, Shuang Qi Zhu, Shitao Zou, Hengrui Chen, Xiaoqin Li, Chao He, Liangsu Zhou, Yan Mei, Weiqun Ding, Jundong Zhou, Yue Zhou, Yuandong Cao

Journal: Cell Death Dis

PubMed ID: 38402183

Doi: 10.1038/s41419-024-06552-6

Products & Services: Protein and Antibody Isolation

SARS-CoV-2 Membrane protein regulates the function of Spike by inhibiting its plasma membrane localization and enzymatic activity of Furin

Authors: Qi Xiang, Jie Wu, Yuzheng Zhou, Linhao Li, Miao Tian, Guobao Li, Zheng Zhang, Yang Fu

Journal: Microbiol Res

PubMed ID: 38430890

Doi: 10.1016/j.micres.2024.127659

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Targeting deoxynivalenol for degradation by a chimeric manganese peroxidase/glutathione system

Authors: Xiaoyun Su, Shuai Wang, Xiaolu Wang, Wangli Ji, Honglian Zhang, Tao Tu, Nina Hakulinen, Huiying Luo, Wei Zhang, Huoqing Huang

Journal: Ecotoxicol Environ Saf

PubMed ID: 38394761

Doi: 10.1016/j.ecoenv.2024.116130

Maternal Phlorizin Intake Protects Offspring from Maternal Obesity-Induced Metabolic Disorders in Mice via Targeting Gut Microbiota to Activate the SCFA-GPR43 Pathway

Authors: Xueran Mei, Yi Li, Xiaoyu Zhang, Xiwen Zhai, Yi Yang, Zhengjuan Li, Liping Li

Journal: J Agric Food Chem

PubMed ID: 38349207

Doi: 10.1021/acs.jafc.3c06370

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Structure of the p53 degradation complex from HPV16

Authors: John C K Wang, Hannah T Baddock, Amirhossein Mafi, Ian T Foe, Matthew Bratkowski, Ting-Yu Lin, Zena D Jensvold, Magdalena Preciado López, David Stokoe, Dan Eaton, Qi Hao, Aaron H Nile

Journal: Nat Commun

PubMed ID: 38418456

Doi: 10.1038/s41467-024-45920-w

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Progranulin haploinsufficiency mediates cytoplasmic TDP-43 aggregation with lysosomal abnormalities in human microglia

Authors: Wonjae Sung, Min-Young Noh, Minyeop Nahm, Yong Sung Kim, Chang-Seok Ki, Young-Eun Kim, Hee-Jin Kim, Seung Hyun Kim

Journal: J Neuroinflammation

PubMed ID: 38347588

Doi: 10.1186/s12974-024-03039-1

Products & Services: Gene Synthesis

Structure-Based Engineering of a Sesquiterpene Cyclase to Generate an Alcohol Product: Conversion of -Isozizaene Synthase into α-Bisabolol Synthase

Authors: Samuel A Eaton, David W Christianson