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Engineering Scheffersomyces segobiensis for palmitoleic acid-rich lipid production
Authors: Xiujuan Qian, Huirui Lei, Xinhai Zhou, Lili Zhang, Wenxing Cui, Jie Zhou, Fengxue Xin, Weiliang Dong, Min Jiang, Katrin Ochsenreither
Journal: Microb Biotechnol
PubMed ID: 37351580
Doi: 10.1111/1751-7915.14301
Products & Services: Codon Optimization   
Effect of moderate prenatal ethanol exposure on the differential expression of two histamine H3 receptor isoforms in different brain regions of adult rat offspring
Authors: Suzy Davies, Kiana S Lujan, Ella J Rappaport, Carlos F Valenzuela, Daniel D Savage
Journal: Front Neurosci
PubMed ID: 37449267
Doi: 10.3389/fnins.2023.1192096
Multisite transformation in : insights on transformations mechanisms and new genetic modification protocols
Authors: Vui Yin Seow, Olga Tsygelnytska, Nicolas Biais
Journal: Front Microbiol
PubMed ID: 37408636
Doi: 10.3389/fmicb.2023.1178128
Products & Services: Gene Synthesis   
MERS-CoV RBD-mRNA vaccine induces potent and broadly neutralizing antibodies with protection against MERS-CoV infection
Authors: Wanbo Tai, Jian Zheng, Xiujuan Zhang, Juan Shi, Gang Wang, Xiaoqing Guan, Jiang Zhu, Stanley Perlman, Lanying Du
Journal: Virus Res
PubMed ID: 37336390
Doi: 10.1016/j.virusres.2023.199156
Products & Services: Molecular Biology Reagents   
Two Recombinant Bacteriocins, Rhamnosin and Lysostaphin, Show Synergistic Anticancer Activity Against Gemcitabine-Resistant Cholangiocarcinoma Cell Lines
Authors: Kankamol Kerdkumthong, Wannarat Chanket, Phanthipha Runsaeng, Sutthipong Nanarong, Kawinnath Songsurin, Phonprapavee Tantimetta, Chanan Angsuthanasombat, Aratee Aroonkesorn, Sumalee Obchoei
Journal: Probiotics Antimicrob Proteins
PubMed ID: 37294416
Doi: 10.1007/s12602-023-10096-0
Products & Services: Molecular Biology Reagents   
GRT-R910: a self-amplifying mRNA SARS-CoV-2 vaccine boosts immunity for ≥6 months in previously-vaccinated older adults
Authors: Christine D Palmer, Ciaran D Scallan, Lauren D Kraemer Tardif, Melissa A Kachura, Amy R Rappaport, Daniel O Koralek, Alison Uriel, Leonid Gitlin, Joshua Klein, Matthew J Davis, Harshni Venkatraman, Meghan G Hart, Jason R Jaroslavsky, Sonia Kounlavouth, Martina Marrali, Charmaine N Nganje, Kyounghwa Bae, Tiffany Yan, Katharyn Leodones, Milana Egorova, Sue-Jean Hong, Jenchun Kuan, Silvia Grappi, Pedro Garbes, Karin Jooss, Andrew Ustianowski
Journal: Nat Commun
PubMed ID: 37280238
Doi: 10.1038/s41467-023-39053-9
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Scribble mis-localization induces adaptive resistance to KRAS G12C inhibitors through feedback activation of MAPK signaling mediated by YAP-induced MRAS
Authors: Yuta Adachi, Ryo Kimura, Kentaro Hirade, Shogo Yanase, Yuki Nishioka, Natsumi Kasuga, Rui Yamaguchi, Hiromichi Ebi
Journal: Nat Cancer
PubMed ID: 37277529
Doi: 10.1038/s43018-023-00575-2
Products & Services: PCR Cloning and Subcloning   
Structural mechanism of intracellular autoregulation of zinc uptake in ZIP transporters
Authors: Changxu Pang, Jin Chai, Ping Zhu, John Shanklin, Qun Liu
Journal: Nat Commun
PubMed ID: 37296139
Doi: 10.1038/s41467-023-39010-6
Products & Services: Gene Synthesis   
Flavonoid quercetin and its glucuronide and sulfate conjugates bind to 67-kDa laminin receptor and prevent neuronal cell death induced by serum starvation
Authors: Rayudu Gopalakrishna, Andrew Oh, Lucas Hou, Emily Lee, Jennifer Aguilar, Andrew Li, William J Mack
Journal: Biochem Biophys Res Commun
PubMed ID: 37300941
Doi: 10.1016/j.bbrc.2023.06.007
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Neutralizing Antibodies in COVID-19 Serum from Tatarstan, Russia
Authors: Shaimaa Hamza, Ekaterina Martynova, Ekaterina Garanina, Venera Shakirova, Alisa Bilalova, Svetlana Moiseeva, Ilsiyar Khaertynova, Olesia Ohlopkova, Nataliya Blatt, Maria Markelova, Svetlana Khaiboullina
Journal: Int J Mol Sci
PubMed ID: 37373331
Doi: 10.3390/ijms241210181
Wheat Class III Peroxidase TaPOD70 Is a Potential Susceptibility Factor Negatively Regulating Wheat Resistance to f sp
Authors: Ruobing Li, Xiaoxu Zhang, Bingjie Zhao, Panpan Song, Xiaomei Zhang, Baotong Wang, Qiang Li
Journal: Phytopathology
PubMed ID: 36812407
Doi: 10.1094/PHYTO-01-23-0001-FI
Void Volume Fraction of Granular Scaffolds
Authors: Lindsay Riley, Grace Wei, Yijun Bao, Peter Cheng, Katrina L Wilson, Yining Liu, Yiyang Gong, Tatiana Segura
Journal: Small
PubMed ID: 37267936
Doi: 10.1002/smll.202303466
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A novel self-purified auxiliary protein enhances the lichenase activity towards lichenan for biomass degradation
Authors: Rui Zhou, Lingzhi Zhang, Bo Zeng, Yanhong Zhou, Wenhui Jin, Guangya Zhang
Journal: Appl Microbiol Biotechnol
PubMed ID: 37272940
Doi: 10.1007/s00253-023-12608-y
Rapid and Facile Light-Based Approach to Fabricate Protease-Degradable Poly(ethylene glycol)-norbornene Microgels for Cell Encapsulation
Authors: Ana Mora-Boza, Saron G Ghebrezadik, Johannes E Leisen, Andrés J García
Journal: Adv Healthc Mater
PubMed ID: 37235850
Doi: 10.1002/adhm.202300942
Products & Services: Molecular Biology Reagents   
Schlafen4-MDSC in -induced gastric metaplasia reveals role for GTPases
Authors: Lin Ding, Sulaiman Sheriff, Ricky A Sontz, Juanita L Merchant
Journal: Front Immunol
PubMed ID: 37334372
Doi: 10.3389/fimmu.2023.1139391
Products & Services: Peptide Synthesis   
Functional Diversity of Homologous Oxidoreductases-Tuning of Substrate Specificity by a FAD-Stacking Residue for Iron Acquisition and Flavodoxin Reduction
Authors: Marta Hammerstad, Anne Kristine Rugtveit, Sondov Dahlen, Hilde Kristin Andersen, Hans-Petter Hersleth
Journal: Antioxidants (Basel)
PubMed ID: 37371954
Doi: 10.3390/antiox12061224
Products & Services: Gene Synthesis   
Engineering B cells with customized therapeutic responses using a synthetic circuit
Authors: Audrey Page, Marie Delles, Didier Nègre, Caroline Costa, Floriane Fusil, François-Loïc Cosset
Journal: Mol Ther Nucleic Acids
PubMed ID: 37359346
Doi: 10.1016/j.omtn.2023.05.024
Products & Services: PCR Cloning and Subcloning   
Adenine transversion editors enable precise, efficient A•T-to-C•G base editing in mammalian cells and embryos
Authors: Liang Chen, Mengjia Hong, Changming Luan, Hongyi Gao, Gaomeng Ru, Xinyuan Guo, Dujuan Zhang, Shun Zhang, Changwei Li, Jun Wu, Peyton B Randolph, Alexander A Sousa, Chao Qu, Yifan Zhu, Yuting Guan, Liren Wang, Mingyao Liu, Bo Feng, Gaojie Song, David R Liu, Dali Li
Journal: Nat Biotechnol
PubMed ID: 37322276
Doi: 10.1038/s41587-023-01821-9
Folding Double-Stranded DNA into Designed Shapes with Triplex-Forming Oligonucleotides
Authors: Cindy Ng , Anirban Samanta , Ole Aalund Mandrup , Emily Tsang , Sarah Youssef , Lasse Hyldgaard Klausen , Mingdong Dong , Minke A D Nijenhuis , Kurt V Gothelf
Journal: Adv Mater .
PubMed ID: 37311656
Doi: 10.1002/adma.202302497
Products & Services: DNA Sequencing   
A mitotic NADPH upsurge promotes chromosome segregation and tumour progression in aneuploid cancer cells
Authors: Aoxing Cheng, Tian Xu , Weiyi You, Ting Wang, Dongming Zhang, Huimin Guo , Haiyan Zhang , Xin Pan , Yucai Wang , Liu Liu , Kaiguang Zhang , Jue Shi , Xuebiao Yao , Jing Guo , Zhenye Yang
Journal: Nat Metab .
PubMed ID: 37349486
Doi: 10.1038/s42255-023-00832-9
Improving therapeutic protein secretion in the probiotic yeast Saccharomyces boulardii using a multifactorial engineering approach
Authors: Deniz Durmusoglu, Ibrahim Al'Abri, Zidan Li, Taufika Islam Williams, Leonard B Collins, José L Martínez, Nathan Crook
Journal: Microb Cell Fact
PubMed ID: 37287064
Doi: 10.1186/s12934-023-02117-y
Spt6 directly interacts with Cdc73 and is required for Paf1 complex occupancy at active genes in Saccharomyces cerevisiae
Authors: Mitchell A Ellison, Sanchirmaa Namjilsuren, Margaret K Shirra, Matthew S Blacksmith, Rachel A Schusteff, Eleanor M Kerr, Fei Fang, Yufei Xiang, Yi Shi, Karen M Arndt
Journal: Nucleic Acids Res
PubMed ID: 36928138
Doi: 10.1093/nar/gkad180
Targeted sequencing of cancer-related genes reveals a recurrent TOP2A variant which affects DNA binding and coincides with global transcriptional changes in glioblastoma
Authors: Bartlomiej Gielniewski, Katarzyna Poleszak, Adria-Jaume Roura, Paulina Szadkowska, Karol Jacek, Sylwia K Krol, Rafal Guzik, Paulina Wiechecka, Marta Maleszewska, Beata Kaza, Andrzej Marchel, Tomasz Czernicki, Andrzej Koziarski, Grzegorz Zielinski, Andrzej Styk, Maciej Kawecki, Cezary Szczylik, Ryszard Czepko, Mariusz Banach, Wojciech Kaspera, Wojciech Szopa, Mateusz Bujko, Bartosz Czapski, Miroslaw Zabek, Ewa Iżycka-Świeszewska, Wojciech Kloc, Pawel Nauman, Joanna Cieslewicz, Wieslawa Grajkowska, Natalia Morosini, Houtan Noushmehr, Bartosz Wojtas, Bozena Kaminska
Journal: Int J Cancer
PubMed ID: 37338006
Doi: 10.1002/ijc.34631
Cytotoxicity of human antibodies targeting the circumsporozoite protein is amplified by 3D substrate and correlates with protection
Authors: Manuela C Aguirre-Botero, Lawrence T Wang, Pauline Formaglio, Eduardo Aliprandini, Jean-Michel Thiberge, Arne Schön, Yevel Flores-Garcia, Shamika Mathis-Torres, Barbara J Flynn, Lais da Silva Pereira, Yann Le Duff, Mathew Hurley, Adéla Nacer, Paul W Bowyer, Fidel Zavala, Azza H Idris, Joseph R Francica, Robert A Seder, Rogerio Amino
Journal: Cell Rep
PubMed ID: 37389992
Doi: 10.1016/j.celrep.2023.112681
Products & Services: Peptide Synthesis   
Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases
Authors: Victoria A Kleiner, Thierry O Fischmann, John A Howe, Douglas C Beshore, Michael J Eddins, Yan Hou, Todd Mayhood, Daniel Klein, Debbie D Nahas, Bob J Lucas, He Xi, Edward Murray, Daphne Y Ma, Krista Getty, Rachel Fearns
Journal: Commun Biol
PubMed ID: 37337079
Doi: 10.1038/s42003-023-04990-0
Products & Services: Codon Optimization   
Near atmospheric carbon dioxide activates plant ubiquitin cross-linking
Authors: Harry G Gannon, Martin J Cann
Journal: BBA Adv
PubMed ID: 37416898
Doi: 10.1016/j.bbadva.2023.100096
Products & Services: Molecular Biology Reagents   
A bioengineered pseudovirus nanoparticle displaying SARS-CoV 2 RBD fully protects mice from mortality and weight loss caused by SARS-CoV 2 challenge
Authors: Ming Xia, Krisangel López, Frank S Vago, Pengwei Huang, Dawn I Auguste, Wen Jiang, Albert J Auguste, Ming Tan
Journal: Biotechnol J
PubMed ID: 37300425
Doi: 10.1002/biot.202300130
Products & Services: Molecular Biology Reagents   
Assessing the Feasibility of Employing a Combination of a Bacteriophage-Derived Endolysin and Spore Germinants to Treat Relapsing Infection
Authors: Khalid Alyahya, Les Baillie
Journal: Microorganisms
PubMed ID: 37512824
Doi: 10.3390/microorganisms11071651
Products & Services: Custom Vector Construction   
Expression and characterization of recombinant IL-1Ra in Aspergillus oryzae as a system
Authors: Lena Mahmoudi Azar, Elif Karaman, Burcu Beyaz, Işılay Göktan, Alp Ertunga Eyüpoğlu, Seda Kizilel, Batu Erman, Ahmet Gül, Serdar Uysal
Journal: BMC Biotechnol
PubMed ID: 37340430
Doi: 10.1186/s12896-023-00785-7
Products & Services: Gene Synthesis   
Identification of paeoniflorin from Paeonia lactiflora pall As an inhibitor of tryptophan 2,3-dioxygenase and assessment of its pharmacological effects on depressive mice
Authors: Xiaoxia Liang, Ting Su, Pingzhou Wu, Yanting Dai, Yanmin Chen, QiQi Wang, Cheng Cao, Fenglian Chen, Qing Wang, Shuling Wang
Journal: J Ethnopharmacol
PubMed ID: 37315645
Doi: 10.1016/j.jep.2023.116714
Antibody aggregation can lead to reduced Protein A binding capacity and low step yield
Authors: Gaoya Yuan, Meng Qu, Qi Geng, Wanyuan Dong, Xudong Zhang, Yifeng Li
Journal: Protein Expr Purif
PubMed ID: 37271409
Doi: 10.1016/j.pep.2023.106315
Targeted deprivation of methionine with engineered Salmonella leads to oncolysis and suppression of metastasis in broad types of animal tumor models
Authors: Sujin Zhou, Yan Lin, Zhenggang Zhao, Yunhao Lai, Mengmeng Lu, Zishen Shao, Xinyu Mo, Yunping Mu, Zhipeng Liang, Xinxing Wang, Jingming Qu, Hua Shen, Fanghong Li, Allan Z Zhao
Journal: Cell Rep Med
PubMed ID: 37269826
Doi: 10.1016/j.xcrm.2023.101070
Products & Services: Custom Vector Construction   
Homology-independent targeted insertion (HITI) enables guided CAR knock-in and efficient clinical scale CAR-T cell manufacturing
Authors: Hyatt Balke-Want, Vimal Keerthi, Nikolaos Gkitsas, Andrew G Mancini, Gavin L Kurgan, Carley Fowler, Peng Xu, Xikun Liu, Kyle Asano, Sunny Patel, Christopher J Fisher, Annie K Brown, Ramya H Tunuguntla, Shabnum Patel, Elena Sotillo, Crystal L Mackall, Steven A Feldman
Journal: Mol Cancer
PubMed ID: 37365642
Doi: 10.1186/s12943-023-01799-7
Genome-wide characterization of extrachromosomal circular DNA in gastric cancer and its potential role in carcinogenesis and cancer progression
Authors: Xianming Jiang, Xiaoguang Pan, Wenchao Li, Peng Han, Jiaying Yu, Jing Li, Haoran Zhang, Wei Lv, Ying Zhang, Yulong He, Xi Xiang
Journal: Cell Mol Life Sci
PubMed ID: 37369919
Doi: 10.1007/s00018-023-04838-0
ENPP1 is an innate immune checkpoint of the anticancer cGAMP-STING pathway
Authors: Songnan Wang, Volker Böhnert, Alby J Joseph, Valentino Sudaryo, Jason Swinderman, Feiqiao B Yu, Xuchao Lyu, Gemini Skariah, Vishvak Subramanyam, Luke A Gilbert, Hani Goodarzi, Li Lingyin
Journal: biorxiv
PubMed ID: 37333273
Doi: 10.1101/2023.06.01.543353
CLDN182 and 4-1BB bispecific antibody givastomig exerts antitumor activity through CLDN182-expressing tumor-directed T-cell activation
Authors: Jing Gao, Zhengyi Wang, Wenqing Jiang, Yanni Zhang, Zhen Meng, Yanling Niu, Zhen Sheng, Chan Chen, Xuejun Liu, Xi Chen, Chanjuan Liu, Keren Jia, Cheng Zhang, Haiyan Liao, Jaeho Jung, Eunsil Sung, Hyejin Chung, Jingwu Z Zhang, Andrew X Zhu, Lin Shen
Journal: J Immunother Cancer
PubMed ID: 37364935
Doi: 10.1136/jitc-2023-006704
Development of MDCK-based quadrivalent split seasonal influenza virus vaccine with high safety and immunoprotection: A preclinical study
Authors: Jiayou Zhang, Xuanxuan Nian, Bo Liu, Zhegang Zhang, Wei Zhao, Xixin Han, Yumei Ma, Dongwu Jin, Hua Ma, Qingmei Zhang, Ran Qiu, Fang Li, Zheng Gong, Xuedan Li, Ying Yang, Yichao Tian, Li Zhou, Kai Duan, Xinguo Li, Zhongren Ma, Xiaoming Yang
Journal: Antiviral Res
PubMed ID: 37270159
Doi: 10.1016/j.antiviral.2023.105639
Products & Services: Molecular Biology Reagents   
Intact mass analysis reveals the novel O-linked glycosylation on the stalk region of PD-1 protein
Authors: Phanthakarn Tit-Oon, Arisa Wonglangka, Klaichan Boonkanta, Mathuros Ruchirawat, Mayuree Fuangthong, Ram Sasisekharan, Amnart Khongmanee
Journal: Sci Rep
PubMed ID: 37316505
Doi: 10.1038/s41598-023-36203-3
Products & Services: Molecular Biology Reagents   
Development of allosteric and selective CDK2 inhibitors for contraception with negative cooperativity to cyclin binding
Authors: Erik B Faber, Luxin Sun, Jian Tang, Emily Roberts, Sornakala Ganeshkumar, Nan Wang, Damien Rasmussen, Abir Majumdar, Laura E Hirsch, Kristen John, An Yang, Hira Khalid, Jon E Hawkinson, Nicholas M Levinson, Vargheese Chennathukuzhi, Daniel A Harki, Ernst Schönbrunn, Gunda I Georg
Journal: Nat Commun
PubMed ID: 37270540
Doi: 10.1038/s41467-023-38732-x
Products & Services: Molecular Biology Reagents   
Grafting Rhodobacter sphaeroides with red algae Rubisco to accelerate catalysis and plant growth
Authors: Yu Zhou, Laura H Gunn, Rosemary Birch, Inger Andersson, Spencer M Whitney
Journal: Nat Plants
PubMed ID: 37291398
Doi: 10.1038/s41477-023-01436-7
Products & Services: Molecular Biology Reagents   
Glutamine synthetase (GS) knockout (KO) using CRISPR/Cpf1 diversely enhances selection efficiency of CHO cells expressing therapeutic antibodies
Authors: Witsanu Srila, Martina Baumann, Markus Riedl, Kuntalee Rangnoi, Nicole Borth, Montarop Yamabhai
Journal: Sci Rep
PubMed ID: 37380701
Doi: 10.1038/s41598-023-37288-6
An Inferred Ancestral CotA Laccase with Improved Expression and Kinetic Efficiency
Authors: Lei Lei, Lijun Zhao, Yiqia Hou, Chen Yue, Pulin Liu, Yanli Zheng, Wenfang Peng, Jiangke Yang
Journal: Int J Mol Sci
PubMed ID: 37446078
Doi: 10.3390/ijms241310901
Products & Services: Recombinant Proteins   
Increasing sensitivity of antibody-antigen interactions using photo-cross-linking
Authors: Alba Torrents de la Peña, Leigh M Sewall, Rebeca de Paiva Froes Rocha, Abigail M Jackson, Payal P Pratap, Sandhya Bangaru, Christopher A Cottrell, Subhasis Mohanty, Albert C Shaw, Andrew B Ward
Journal: Cell Rep Methods
PubMed ID: 37426749
Doi: 10.1016/j.crmeth.2023.100509
Author Correction: RNA conformational propensities determine cellular activity
Authors: Megan L Ken, Rohit Roy, Ainan Geng, Laura R Ganser, Akanksha Manghrani, Bryan R Cullen, Ursula Schulze-Gahmen, Daniel Herschlag, Hashim M Al-Hashimi
Journal: Nature
PubMed ID: 37296211
Doi: 10.1038/s41586-023-06286-z
Products & Services: Peptide Synthesis   
Combined lineage tracing and scRNA-seq reveals unexpected first heart field predominance of human iPSC differentiation
Authors: Francisco X Galdos, Carissa Lee, Soah Lee, Sharon Paige, William Goodyer, Sidra Xu, Tahmina Samad, Gabriela V Escobar, Adrija Darsha, Aimee Beck, Rasmus O Bak, Matthew H Porteus, Sean M Wu
Journal: Elife
PubMed ID: 37284748
Doi: 10.7554/eLife.80075
Products & Services: Molecular Biology Reagents   
Mycobacterium abscessus VapC5 toxin potentiates evasion of antibiotic killing by ribosome overproduction and activation of multiple resistance pathways
Authors: Eduardo A Troian, Heather M Maldonado, Unnati Chauhan, Valdir C Barth, Nancy A Woychik
Journal: Nat Commun
PubMed ID: 37349306
Doi: 10.1038/s41467-023-38844-4
Products & Services: Combinatorial DNA Libraries   
The role of mechano-regulated YAP/TAZ in erectile dysfunction
Authors: Mintao Ji, Dongsheng Chen, Yinyin Shu, Shuai Dong, Zhisen Zhang, Haimeng Zheng, Xiaoni Jin, Lijun Zheng, Yang Liu, Yifei Zheng, Wensheng Zhang, Shiyou Wang, Guangming Zhou, Bingyan Li, Baohua Ji, Yong Yang, Yongde Xu, Lei Chang
Journal: Nat Commun
PubMed ID: 37353497
Doi: 10.1038/s41467-023-39009-z
Knockdown of Yap attenuates TAA-induced hepatic fibrosis by interaction with hedgehog signals
Authors: Ye Zhao, Huiling Wang, Tianhua He, Bo Ma, Guoguang Chen, Chimeng Tzeng
Journal: J Cell Commun Signal
PubMed ID: 37338798
Doi: 10.1007/s12079-023-00775-6
Products & Services: Gene Synthesis   
Identification and Characterization of an HtrA Sheddase Produced by Coxiella burnetii
Authors: Ikram Omar Osman , Aurelia Caputo , Lucile Pinault , Jean-Louis Mege , Anthony Levasseur , Christian A Devaux
Journal: Int J Mol Sci .
PubMed ID: 37446087
Doi: 10.3390/ijms241310904
Products & Services: Gene Synthesis   

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