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miRNA circuit modules for precise, tunable control of gene expression

Authors: Rongrong Du, Michael J Flynn, Monique Honsa, Ralf Jungmann, Michael B Elowitz

Journal: biorxiv

PubMed ID: 38559239

Doi: 10.1101/2024.03.12.583048

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Porcine HERC6 acts as major E3 ligase for ISGylation and is auto-ISGylated for effective ISGylation in porcine

Authors: Cuiyu Ba, Chaonan Tian, Xueying Bo, Chang Xu, Yi Zhang, Xiangyu Sun, Yuchen Nan, Chunyan Wu

Journal: Microb Pathog

PubMed ID: 38554778

Doi: 10.1016/j.micpath.2024.106633

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FANCJ promotes PARP1 activity during DNA replication that is essential in BRCA1 deficient cells

Authors: Ke Cong, Nathan MacGilvary, Silviana Lee, Shannon G MacLeod, Jennifer Calvo, Min Peng, Arne Nedergaard Kousholt, Tovah A Day, Sharon B Cantor

Journal: Nat Commun

PubMed ID: 38521768

Doi: 10.1038/s41467-024-46824-5

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Near-cognate tRNAs increase the efficiency and precision of pseudouridine-mediated readthrough of premature termination codons

Authors: Nan Luo, Qiang Huang, Liting Dong, Wenqing Liu, Jinghui Song, Hanxiao Sun, Hao Wu, Yuan Gao, Chengqi Yi

Journal: Nat Biotechnol

PubMed ID: 38448662

Doi: 10.1038/s41587-024-02165-8

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The aged microenvironment impairs BCL6 and CD40L induction in CD4 T follicular helper cell differentiation

Authors: Jacob S Fisher, Irene Adán-Barrientos, Naveen R Kumar, Jessica N Lancaster

Journal: Aging Cell

PubMed ID: 38481058

Doi: 10.1111/acel.14140

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Expression and functional analysis of a recombinant aquaporin Z from Antarctic Pseudomonas sp AMS3

Authors: S Balakrishnan, R N Z R A Rahman, N D M Noor, W Latip, M S M Ali

Journal: Proteins

PubMed ID: 38477414

Doi: 10.1002/prot.26680

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Molecular basis of TMPRSS2 recognition by Paeniclostridium sordellii hemorrhagic toxin

Authors: Ruoyu Zhou, Liuqing He, Jiahao Zhang, Xiaofeng Zhang, Yanyan Li, Xiechao Zhan, Liang Tao

Journal: Nat Commun

PubMed ID: 38438396

Doi: 10.1038/s41467-024-46394-6

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Effects of annexin B18 from Echinococcus granulosus sensu lato on mouse macrophages

Authors: Yanxin Chen, Ruiqi Hua, Guoqing Shao, Xiaowei Zhu, Wei Hou, Shengqiong Li, Aiguo Yang, Guangyou Yang

Journal: Exp Parasitol

PubMed ID: 38432406

Doi: 10.1016/j.exppara.2024.108723

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Gene regulatory network co-option is sufficient to induce a morphological novelty in

Authors: Gavin Rice, Tatiana Gaitan-Escudero, Kenechukwu Charles-Obi, Julia Zeitlinger, Mark Rebeiz

Journal: biorxiv

PubMed ID: 38585823

Doi: 10.1101/2024.03.22.584840

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Is there an immunological cross-reactivity of antibodies to the myelin oligodendrocyte glycoprotein and coronaviruses?

Authors: Kathrin Schanda, Sara Mariotto, Dagmar Rudzki, Angelika Bauer, Alessandro Dinoto, Patrizia Rossi, Sergio Ferrari, Sven Jarius, Brigitte Wildemann, Federica Boso, Bruno Giometto, Daniel Engels, Tania Kümpfel, Eva-Maria Wendel, Kevin Rostasy, Markus Reindl

Journal: Brain Commun

PubMed ID: 38576796

Doi: 10.1093/braincomms/fcae106

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miR-101-3p-mediated role of PDZK1 in hepatocellular carcinoma progression and the underlying PI3K/Akt signaling mechanism

Authors: Huihui Gao, Zhaofeng Gao, Xiaobei Liu, Xu Sun, Zhonghui Hu, Zhengwei Song, Cheng Zhang, Jianguo Fei, Xiaoguang Wang

Journal: Cell Div

PubMed ID: 38532426

Doi: 10.1186/s13008-023-00106-6

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Isobaric Tags for Relative and Absolute Quantitation-Based Proteomics Analysis Revealed Proteins Involved in Drought Response during the Germination Stage in Faba Bean

Authors: Changyan Liu, Fangwen Yang, Li Li, Xuesong Han, Hongwei Chen, Aihua Sha, Chunhai Jiao

Journal: Metabolites

PubMed ID: 38535335

Doi: 10.3390/metabo14030175

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Analysis of Recombinant Proteins for the Serological Diagnosis of Dourine

Authors: Mirella Luciani, Gisella Armillotta, Tiziana Di Febo, Ivanka Krasteva, Simonetta Ulisse, Chiara Di Pancrazio, Caterina Laguardia, Fabrizia Perletta, Anna Serroni, Marta Maggetti, Lilia Testa, Flavio Sacchini, Mariangela Iorio, Diamante Rodomonti, Manuela Tittarelli, Maria Teresa Mercante

Journal: Vet Sci

PubMed ID: 38535861

Doi: 10.3390/vetsci11030127

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Authors: Chenwei Wang, Jiewen Chen, Jingyao Li, Zhihong Xu, Lihong Huang, Qian Zhao, Lei Chen, Xiaolong Liang, Hai Hu, Gang Li, Chengjie Xiong, Bin Wu, Hua You, Danyi Du, Xiaoling Wang, Hongle Li, Zibing Wang, Lin Chen

Journal: J Clin Invest

PubMed ID: 38412034

Doi: 10.1172/JCI172092

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The molecular interaction pattern of lenvatinib enables inhibition of wild-type or kinase-mutated FGFR2-driven cholangiocarcinoma

Authors: Stephan Spahn, Fabian Kleinhenz, Ekaterina Shevchenko, Aaron Stahl, Yvonne Rasen, Christine Geisler, Kristina Ruhm, Marion Klaumuenzer, Thales Kronenberger, Stefan A Laufer, Holly Sundberg-Malek, Khac Cuong Bui, Marius Horger, Saskia Biskup, Klaus Schulze-Osthoff, Markus Templin, Nisar P Malek, Antti Poso, Michael Bitzer

Journal: Nat Commun

PubMed ID: 38346946

Doi: 10.1038/s41467-024-45247-6

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Autoinhibition and activation of myosin VI revealed by its cryo-EM structure

Authors: Fengfeng Niu, Lingxuan Li, Lei Wang, Jinman Xiao, Shun Xu, Yong Liu, Leishu Lin, Cong Yu, Zhiyi Wei

Journal: Nat Commun

PubMed ID: 38331992

Doi: 10.1038/s41467-024-45424-7

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Cutting Edge: Characterization of Low Copy Number Human Angiotensin-Converting Enzyme 2-Transgenic Mice as an Improved Model of SARS-CoV-2 Infection

Authors: Christine M Bradshaw, Teodora Georgieva, Trevor N Tankersley, Tama Taylor-Doyle, Larry Johnson, Jennifer L Uhrlaub, David Besselsen, Janko Ž Nikolich

Journal: J Immunol

PubMed ID: 38197714

Doi: 10.4049/jimmunol.2300591

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Enhancing CAR Macrophage Efferocytosis Via Surface Engineered Lipid Nanoparticles Targeting LXR Signaling

Authors: Skylar T Chuang, Joshua B Stein, Sarah Nevins, Cemile Kilic Bektas, Hye Kyu Choi, Wan-Kyu Ko, Hyunjun Jang, Jihun Ha, Ki-Bum Lee

Journal: Adv Mater

PubMed ID: 38353580

Doi: 10.1002/adma.202308377

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Molecular Characterization of Plant Volatile Compound Interactions with Odorant-Binding Proteins

Authors: Qi Qian, Xin Guo, Lingjie Wu, Jiarong Cui, Huiying Gao, Yajun Yang, Hongxing Xu, Zhongxian Lu, Pingyang Zhu

Journal: Plants (Basel)

PubMed ID: 38498446

Doi: 10.3390/plants13040479

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Cytokine responses to major human Cytomegalovirus antigens in mouse model

Authors: Sahar Essa, Hussain A Safar, Raj Raghupathy

Journal: Cytokine

PubMed ID: 38359558

Doi: 10.1016/j.cyto.2024.156546

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TGFβ1-induced hedgehog signaling suppresses the immune response of brain microvascular endothelial cells elicited by meningitic Escherichia coli

Authors: Jinrui Sun, Ruicheng Yang, Jiyang Fu, Dong Huo, Xinyi Qu, Chen Tan, Huanchun Chen, Xiangru Wang

Journal: Cell Commun Signal

PubMed ID: 38360663

Doi: 10.1186/s12964-023-01383-y

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AbImmPred: An immunogenicity prediction method for therapeutic antibodies using AntiBERTy-based sequence features

Authors: Hong Wang, Xiaohu Hao, Yuzhuo He, Long Fan

Journal: PLoS ONE

PubMed ID: 38394128

Doi: 10.1371/journal.pone.0296737

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Antiviral activity of immunosuppressors alone and in combination against human adenovirus and cytomegalovirus

Authors: Marta Carretero-Ledesma, Manuela Aguilar-Guisado, Judith Berastegui-Cabrera, María Balsera-Manzanero, Jerónimo Pachón, Elisa Cordero, Javier Sánchez-Céspedes

Journal: Int J Antimicrob Agents

PubMed ID: 38401774

Doi: 10.1016/j.ijantimicag.2024.107116

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A phenylalanine-free recombinant nutritional protein for the dietary management of phenylketonuria

Authors: Yvonne Mücke, Natalia Jablonka, Nicole Rimann, Hiu Man Grisch-Chan, Bernhard Hoffmann, Stefan Schillberg, Beat Thöny, Stefan Rasche

Journal: J Inherit Metab Dis

PubMed ID: 38390655

Doi: 10.1002/jimd.12719

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Mitochondrial amidoxime-reducing component 1 p.Ala165Thr increases protein degradation mediated by the proteasome

Authors: Tanmoy Dutta, Kavitha Sasidharan, Ester Ciociola, Grazia Pennisi, Francesca R Noto, Lohitesh Kovooru, Tobias Kroon, Anna Lindblom, Yue Du, Mohammad Pirmoradian, Simonetta Wallin, Rosellina M Mancina, Daniel Lindén, Stefano Romeo

Journal: Liver Int

PubMed ID: 38375985

Doi: 10.1111/liv.15857

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Borrelia miyamotoi BipA-like protein, BipM, is a candidate serodiagnostic antigen distinguishing between Lyme disease and relapsing fever Borrelia infections

Authors: Kevin S Brandt, Brittany A Armstrong, Irina Goodrich, Robert D Gilmore

Journal: Ticks Tick Borne Dis

PubMed ID: 38367587

Doi: 10.1016/j.ttbdis.2024.102324

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Fusarium graminearum rapid alkalinization factor peptide negatively regulates plant immunity and cell growth via the FERONIA receptor kinase

Authors: Yujie Wang, Xin Liu, Bingqin Yuan, Xue Chen, Hanxi Zhao, Qurban Ali, Minghong Zheng, Zheng Tan, Hemin Yao, Shuqing Zheng, Jingni Wu, Jianhong Xu, Jianrong Shi, Huijun Wu, Xuewen Gao, Qin Gu

Journal: Plant Biotechnol J

PubMed ID: 38344883

Doi: 10.1111/pbi.14303

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Identification of closely related species in through Analysis of Whole-Genome

Authors: Guihong Qi, Lijun Hao, Yutong Gan, Tianyi Xin, Qian Lou, Wenjie Xu, Jingyuan Song

Journal: Front Microbiol

PubMed ID: 38450170

Doi: 10.3389/fmicb.2024.1323572

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Cloning of three epsilon-class glutathione -transferase genes from (Graeser) (Lepidoptera: Notodontidae) and their response to tannic acid

Authors: Ling Zhang, Huizhen Tu, Fang Tang

Journal: Bull Entomol Res

PubMed ID: 38327098

Doi: 10.1017/S0007485323000718

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A Diversity Covering (DiCo) Plasmodium vivax apical membrane antigen-1 vaccine adjuvanted with RFASE/RSL10 yields high levels of growth-inhibitory antibodies

Authors: Bart W Faber, Lee M Yeoh, Liriye Kurtovic, Wim E M Mol, Martin Poelert, Elly Smits, Roberto Rodriguez Garcia, Marjolein Mandalawi-Van der Eijk, Nicole van der Werff, Annemarie Voorberg-van der Wel, Edmond J Remarque, James G Beeson, Clemens H M Kocken

Journal: Vaccine

PubMed ID: 38365484

Doi: 10.1016/j.vaccine.2024.02.029

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Inhibition of the C1s Protease and the Classical Complement Pathway by 6-(4-Phenylpiperazin-1-yl)Pyridine-3-Carboximidamide and Chemical Analogs

Authors: Xin Xu, Timothy J Herdendorf, Huiquan Duan, Denise L Rohlik, Sourav Roy, Hinman Zhou, Haya Alkhateeb, Sanjay Khandelwal, Qilong Zhou, Ping Li, Gowthami M Arepally, John K Walker, Brandon L Garcia, Brian V Geisbrecht

Journal: J Immunol

PubMed ID: 38149922

Doi: 10.4049/jimmunol.2300630

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Nucleocapsid protein-specific monoclonal antibodies protect mice against Crimean-Congo hemorrhagic fever virus

Authors: Aura R Garrison, Vanessa Moresco, Xiankun Zeng, Curtis R Cline, Michael D Ward, Keersten M Ricks, Scott P Olschner, Lisa H Cazares, Elif Karaaslan, Collin J Fitzpatrick, Éric Bergeron, Scott D Pegan, Joseph W Golden

Journal: Nat Commun

PubMed ID: 38409240

Doi: 10.1038/s41467-024-46110-4

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Oral administration of a recombinant modified RBD antigen of SARS-CoV-2 as a possible immunostimulant for the care of COVID-19

Authors: Norma A Valdez-Cruz, Diego Rosiles-Becerril, Constanza E Martínez-Olivares, Enrique García-Hernández, Laura Cobos-Marín, Daniel Garzón, Francisco E López-Salas, Guadalupe Zavala, Axel Luviano, Alejandro Olvera, Alejandro Alagón, Octavio T Ramírez, Mauricio A Trujillo-Roldán

Journal: Microb Cell Fact

PubMed ID: 38321489

Doi: 10.1186/s12934-024-02320-5

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Analysis of heterologous expression of phaCBA promotes the acetoin stress response mechanism in Bacillus subtilis using transcriptomics and metabolomics approaches

Authors: Tao Li, Haixiang Li, Lei Zhong, Yufei Qin, Gege Guo, Zhaoxing Liu, Ning Hao, Pingkai Ouyang

Journal: Microb Cell Fact

PubMed ID: 38383407

Doi: 10.1186/s12934-024-02334-z

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Distribution analysis of TRH in Bactrocera dorsalis using a CRISPR/Cas9-mediated reporter knock-in strain

Authors: Feiyue Teng, Fengyi Guo, Jimei Feng, Yongyue Lu, Yixiang Qi

Journal: Insect Mol Biol

PubMed ID: 38411032

Doi: 10.1111/imb.12901

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Precise Engineering of Growth Factor Presentation Using Extracellular Microenvironment-Mimicking Microfluidic Microparticles

Authors: Mohammad Mahdi Hasani-Sadrabadi, Weihao Yuan, Luiza de Almeida Queiroz Ferreira, Zeyang Liu, Jun Shen, Patricia Sarrión, Fatemeh Sharifi, Atefeh Malek-Khatabi, Erfan Dashtimoghadam, Bo Yu, Sahar Ansari, Alireza Moshaverinia

Journal: ACS Biomater Sci Eng

PubMed ID: 38347681

Doi: 10.1021/acsbiomaterials.3c01922

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Arabidopsis thaliana RHAMNOSE 1 condensate formation drives UDP-rhamnose synthesis

Authors: Sterling Field, Yanniv Dorone, Will P Dwyer, Jack A Cox, Dan Raba, John Froehlich, Madison Blea, Olivia M S Carmo, Ian S Wallace, Renee Hastings, Steven Boeynaems, Seung Y Rhee

Journal: biorxiv

PubMed ID: 38464008

Doi: 10.1101/2024.02.15.580454

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Tubule-specific cyclin-dependent kinase 12 knockdown potentiates kidney injury through transcriptional elongation defects

Authors: Yi-Lin Zhang, Tao-Tao Tang, Wei-Jie Ni, Zhong-Tang Li, Liang-Yun-Zi Jiang, Yao Wang, Xuan Zhou, Jing-Yuan Cao, Qing Yin, Wei Jiang, Ya-Jie Zhao, Wei-Hua Gan, Ai-Qing Zhang, Zuo-Lin Li, Yi Wen, Lin-Li Lv, Bi-Cheng Liu, Bin Wang

Journal: Int J Biol Sci

PubMed ID: 38481813

Doi: 10.7150/ijbs.90872

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A recent gibbon ape leukemia virus germline integration in a rodent from New Guinea

Authors: Saba Mottaghinia, Saskia Stenzel, Kyriakos Tsangaras, Nikolas Nikolaidis, Michael Laue, Karin Müller, Henriette Hölscher, Ulrike Löber, Gayle K McEwen, Stephen C Donnellan, Kevin C Rowe, Ken P Aplin, Christine Goffinet, Alex D Greenwood

Journal: Proc Natl Acad Sci U S A

PubMed ID: 38305758

Doi: 10.1073/pnas.2220392121

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Molecular recognition and activation of the prostacyclin receptor by anti-pulmonary arterial hypertension drugs

Authors: James Jiqi Wang, Sanshan Jin, Heng Zhang, Youwei Xu, Wen Hu, Yi Jiang, Chen Chen, Dao Wen Wang, H Eric Xu, Canrong Wu

Journal: Sci Adv .

PubMed ID: 38335293

Doi: 10.1126/sciadv.adk5184

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SRRM2 phase separation drives assembly of nuclear speckle subcompartments

Authors: Mengjun Zhang, Zhuang Gu, Shuanghui Guo, Yingtian Sun, Suibin Ma, Shuo Yang, Jierui Guo, Chenxi Fang, Li Shu, Yifan Ge, Zhongwen Chen, Bo Wang

Journal: Cell Rep .

PubMed ID: 38381607

Doi: 10.1016/j.celrep.2024.113827

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An Insertion Within SIRPβ1 Shows a Dual Effect Over Alzheimer’s Disease Cognitive Decline Altering the Microglial Response

Authors: José María García-Alberca, Itziar de Rojas, Elisabeth Sanchez-Mejias , Diego Garrido-Martín

Journal: JOURNAL OF ALZHEIMERS DISEASE

PubMed ID: 38427484

Doi: 10.3233/JAD-231150

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N-homocysteinylation of DJ-1 promotes neurodegeneration in Parkinson's disease

Authors: Tao Guo, Lingyan Zhou, Min Xiong, Jing Xiong, Juan Huang, Yiming Li, Guoxin Zhang, Guiqin Chen, Zhi-Hao Wang, Tingting Xiao, Dan Hu, Anyu Bao, Zhentao Zhang

Journal: Aging Cell

PubMed ID: 38380563

Doi: 10.1111/acel.14124

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Rapid simulation of glycoprotein structures by grafting and steric exclusion of glycan conformer libraries

Authors: Yu-Xi Tsai, Ning-En Chang, Klaus Reuter, Hao-Ting Chang, Tzu-Jing Yang, Sören von Bülow, Vidhi Sehrawat, Noémie Zerrouki, Matthieu Tuffery, Michae Gecht, Isabell Louise Grothaus, Lucio Colombi Ciacchi, Yong-Sheng Wang, Min-Feng Hsu, Kay-Hooi Khoo, Gerhard Hummer, Shang-Te Danny Hsu, Cyril Hanus , Mateusz Sikora

Journal: Cell

PubMed ID: 38428397

Doi: 10.1016/j.cell.2024.01.034

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hRpn13 shapes the proteome and transcriptome through epigenetic factors HDAC8, PADI4, and transcription factor NF-κB p50

Authors: Vasty Osei-Amponsa, Monika Chandravanshi, Xiuxiu Lu , Valentin Magidson, Sudipto Das, Thorkell Andresson, Marzena Dyba, Venkata R Sabbasani, Rolf E Swenson, Caroline Fromont, Biraj Shrestha, Yongmei Zhao, Michelle E Clapp, Raj Chari, Kylie J Walters

Journal: Cell

PubMed ID: 38151017

Doi: 10.1016/j.molcel.2023.11.035

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MFSD7c functions as a transporter of choline at the blood–brain barrier

Authors: Xuan Thi Anh Nguyen, Thanh Nha Uyen Le, Toan Q. Nguyen, Hoa Thi Thuy Ha, Anna Artati, Nancy C. P. Leong, Dat T. Nguyen, Pei Yen Lim, Adelia Vicanatalita Susanto, Qianhui Huang, Ling Fam, Lo Ngah Leong, Isabelle Bonne, Angela Lee, Jorge L. Granadillo, Catherine Gooch, Dejie Yu, Hua Huang, Tuck Wah Soong, Matthew Wook Chang, Markus R. Wenk, Jerzy Adamski, Amaury Cazenave-Gassiot & Long N. Nguyen

Journal: Cell Research

PubMed ID: 38302740

Doi: 10.1038/s41422-023-00923-y

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Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase

Authors: Julia Lederhofer, Yaroslav Tsybovsky, Lam Nguyen, Julie E Raab, Adrian Creanga, Tyler Stephens, Rebecca A Gillespie, Hubza Z Syeda, Brian E Fisher, Michelle Skertic , Christina Yap, Andrew J Schaub, Reda Rawi, Peter D Kwong, Barney S Graham, Adrian B McDermott , Sarah F Andrews , Neil P King , Masaru Kanekiyo

Journal: Immunity

PubMed ID: 38430907

Doi: 10.1016/j.immuni.2024.02.003

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Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks

Authors: Carla A Jaeger-Ruckstuhl Yun Lo, Elena Fulton , Olivia G Waltner, Tamer B Shabaneh , Sylvain Simon , Pranav V Muthuraman , Colin E Correnti , Oliver J Newsom , Ian A Engstrom , Sami B Kanaan , Shruti S Bhise , Jobelle M C Peralta , Raymond Ruff , Jason P Price , Sylvia M Stull , Andrew R Stevens , Grace Bugos, Mitchell G Kluesner , Valentin Voillet, Vishaka Muhunthan, Fionnuala Morrish, James M Olson , Raphaël Gottado , Jay F Sarthy, Steven Henikoff , Lucas B Sullivan, Scott N Furlan, Stanley R Riddell

Journal: Immunity

PubMed ID: 38354704

Doi: 10.1016/j.immuni.2024.01.011

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Local structural preferences in shaping tau amyloid polymorphism

Authors: Nikolaos Louros , Martin Wilkinson , Grigoria Tsaka , Meine Ramakers , Chiara Morelli , Teresa Garcia , Rodrigo Gallardo , Sam D'Haeyer , Vera Goossens , Dominique Audenaert , Dietmar Rudolf Thal , Ian R Mackenzie , Rosa Rademakers , Neil A Ranson , Sheena E Radford , Frederic Rousseau , Joost Schymkowitz

Journal: Nat Commun

PubMed ID: 38310108

Doi: 10.1038/s41467-024-45429-2

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ZSCAN10 deficiency causes a neurodevelopmental disorder with characteristic oto-facial

Authors: Lucia Laugwitz, Fubo Cheng, Stephan C Collins, Alexander Hustinx, Nicolas Navarro, Simon Welsch, Helen Cox, Tzung-Chien Hsieh, Aswinkumar Vijayananth, Rebecca Buchert, Benjamin Bender, Stephanie Efthymiou, David Murphy, Faisal Zafar, Nuzhat Rana, Ute Grasshoff, Ruth J Falb, Mona Grimmel, Annette Seibt, Wenxu Zheng, Hamid Ghaedi, Marie Thirion, Sébastien Couette, Reza Azizimalamiri, Saeid Sadeghian, Hamid Galehdari, Mina Zamani, Jawaher Zeighami, Alireza Sedaghat, Samira Molaei Ramshe, Ali Zare, Behnam Alipoor, Dirk Klee,

Journal: Brain

PubMed ID: 38386308

Doi: 10.1093/brain/awae058

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