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Cyclic di-GMP inhibits nitrate assimilation by impairing the antitermination function of NasT in Pseudomonas putida

Authors: Liang Nie, Yujie Xiao, Tiantian Zhou, Haoqi Feng, Meina He, Qingyuan Liang, Kexin Mu, Hailing Nie, Qiaoyun Huang, Wenli Chen

Journal: Nucleic Acids Res

PubMed ID: 38000372

Doi: 10.1093/nar/gkad1117

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CGI1746 targets σ1R to modulate ferroptosis through mitochondria-associated membranes

Authors: Zili Zhang, Hong Zhou, Wenjia Gu, Yuehan Wei, Shan Mou, Youjun Wang, Jing Zhang & Qing Zhong

Journal: Nature Chemical Biology

PubMed ID: 38212578

Doi: 10.1038/s41589-023-01512-1

Products & Services: Recombinant Antibody Expression

Identification of a broad sarbecovirus neutralizing antibody targeting a conserved epitope on the receptor-binding domain

Authors: Yanqun Wang, Zhaoyong Zhang, Minnan Yang, Xinyi Xiong, Qihong Yan, Lei Cao, Peilan Wei, Yuting Zhang, Lu Zhang, Kexin Lv, Jiantao Chen, Xuesong Liu, Xiaochu Zhao, Juxue Xiao, Shengnan Zhang, Airu Zhu, Mian Gan, Jingjun Zhang, Ruoxi Cai, Jianfen Zhuo, Yanjun Zhang, Haiyue Rao, Bin Qu, Yuanyuan Zhang, Lei Chen, Jun Dai, Linling Cheng, Qingtao Hu, Yaoqing Chen, Huibin Lv, Ray T Y So, Malik Peiris, Jingxian Zhao, Xiaoqing Liu, Chris Ka Pun Mok, Xiangxi Wang, Jincun Zhao

Journal: Cell Rep

PubMed ID: 38175758

Doi: 10.1016/j.celrep.2023.113653

Products & Services: Recombinant Proteins

Tomato-made edible COVID-19 vaccine TOMAVAC induces neutralizing IgGs in the blood sera of mice and humans

Authors: Zabardast T Buriev, Shukhrat E Shermatov, Dilshod E Usmanov, Mukhammadjon K Mirzakhmedov, Khurshida A Ubaydullaeva, Venera S Kamburova, Bakhtiyor K Rakhmanov, Mirzakamol S Ayubov, Adkham N Abdullaev

Journal: Front Nutr

PubMed ID: 38260078

Doi: 10.3389/fnut.2023.1275307

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Disordered-to-ordered transitions in assembly factors allow the complex II catalytic subunit to switch binding partners

Authors: Pankaj Sharma, Elena Maklashina, Markus Voehler, Sona Balintova , Sarka Dvorakova, Michal Kraus, Katerina Hadrava Vanova Zuzana Nahacka, Renata Zobalova, Stepana Boukalova, Kristyna Cunatova, Tomas Mracek, Hans K Ghayee, Karel Pacak, Jakub Rohlena, Jiri Neuzil, Gary Cecchini,T M Iverson

Journal: Nat Commun

PubMed ID: 38212624

Doi: 10.1038/s41467-023-44563-7

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GDF15 linked to maternal risk of nausea and vomiting during pregnancy

Authors: M Fejzo # 1, N Rocha Cimino # 2, S M Lockhart # 2, C J Petry # 2, R G Kay 2 3, K Burling 2 4, P Barker 2 4, A L George 3, N Yasara 5, A Premawardhena 6 7, S Gong 8 9, E Cook 8, D Rimmington 2, K Rainbow 2, D J Withers 2, V Cortessis 10, P M Mullin 11, K W MacGibbon 12, E Jin, A Kam, A Campbell , O Polasek , G Tzoneva , F M Gribble , G S H Yeo , B Y H Lam , V Saudek, I A Hughes, K K Ong, J R B Perry , A Sutton Cole , M Baumgarten , P Welsh , N Sattar , G C S Smith , D S Charnock-Jones, A P Coll, C L Meek Mettananda , C Hayward, N Mancuso , S O'Rahilly

Journal: Nature

PubMed ID: 38092039

Doi: 10.1038/s41586-023-06921-9

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Streptococcus anginosus promotes gastric inflammation, atrophy, and tumorigenesis in mice

Authors: Kaili Fu 1, Alvin Ho Kwan Cheung 2, Chi Chun Wong 1, Weixin Liu 1, Yunfei Zhou 1, Feixue Wang 1, Pingmei Huang 1, Kai Yuan 1, Olabisi Oluwabukola Coker 1, Yasi Pan 1, Danyu Chen 1, Nga Man Lam 3, Mengxue Gao 4, Xiang Zhang 1, He Huang 4, Ka Fai To 2, Joseph Jao Yiu Sung 5, Jun Yu

Journal: Cell

PubMed ID: 38295787

Doi: 10.1016/j.cell.2024.01.004

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Smart lattice light-sheet microscopy for imaging rare and complex cellular events

Authors: Yu Shi , Jimmy S Tabet , Daniel E Milkie , Timothy A Daugird , Chelsea Q Yang , Alex T Ritter , Andrea Giovannucci , Wesley R Legant

Journal: Nat Methods

PubMed ID: 38167656

Doi: 10.1038/s41592-023-02126-0

Products & Services: PCR Cloning and Subcloning

Circ_0087199 depletion attenuates lipopolysaccharides-induced human periodontal ligament cell injury through the miR-527/TLR4 axis

Authors: Jing Wang , Na Huo , Chuan Cai , Yu Zhang, Rui Xiao

Journal: Immunity

PubMed ID: 38270303

Doi: 10.1002/iid3.1153

Omicron Spike confers enhanced infectivity and interferon resistance to SARS-CoV-2 in human nasal tissue

Authors: Guoli Shi , Tiansheng Li , Kin Kui Lai , Reed F Johnson , Jonathan W Yewdell , Alex A Compton

Journal: Nat Commun

PubMed ID: 38291024

Doi: 10.1038/s41467-024-45075-8

Products & Services: PCR Cloning and Subcloning

MARS an improved de novo peptide candidate selection method for non-canonical antigen target discovery in cancer

Authors: Hanqing Liao , Carolina Barra , Zhicheng Zhou , Xu Peng , Isaac Woodhouse , Arun Tailor , Robert Parker , Alexia Carré , Persephone Borrow , Michael J Hogan , Wayne Paes , Laurence C Eisenlohr , Roberto Mallone , Morten Nielsen , Nicola Ternette

Journal: Nat Commun

PubMed ID: 38253617

Doi: 10.1038/s41467-023-44460-z

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Role of UPF1-LIN28A interaction during early differentiation of pluripotent stem cells

Authors: Seungwon Jung , Seung Hwan Ko , Narae Ahn , Jinsam Lee , Chang-Hwan Park , Jungwook Hwang

Journal: Nat Commun

PubMed ID: 38167913

Doi: 10.1038/s41467-023-44600-5

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The role of CD38 in inflammation-induced depression-like behavior and the antidepressant effect of (R)-ketamine

Authors: Xinying Zhang a , Teng He a , Zifeng Wu a , Yuanyuan Wang a, Hanyu Liu a, Bingyuan Zhang a, Siqi Yang a, Di Wang a, Chaoli Huang a, Jiahao Duan b, Xiangyang Xu c, Xiangqing Xu c, Kenji Hashimoto d, Riyue Jiang e, Ling Yang b, Chun Yang

Journal: Brain, behavior, and immunity

PubMed ID: 37793489

Doi: 10.1016/j.bbi.2023.09.026

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The role of the Toll like receptor 4 signaling in sex-specific persistency of depression-like behavior in response to chronic stress

Authors: Eun-Jeong Yang , Tal Frolinger , Umar Iqbal , Molly Estill , Li Shen , Kyle J Trageser , Giulio M Pasinetti

Journal: Brain, behavior, and immunity

PubMed ID: 37838079

Doi: 10.1016/j.bbi.2023.10.006

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Acylspermidines are conserved mitochondrial sirtuin-dependent metabolites

Authors: Bingsen Zhang, James Mullmann, Andreas H. Ludewig, Irma R. Fernandez, Tyler R. Bales, Robert S. Weiss & Frank C. Schroeder

Journal: Nature Chemical Biology

PubMed ID: 38167917

Doi: 10.1038/s41589-023-01511-2

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A framework for Frizzled-G protein coupling and implications to the PCP signaling pathways

Authors: Zhibin Zhang , Xi Lin , Ling Wei , Yiran Wu , Lu Xu , Lijie Wu , Xiaohu Wei , Suwen Zhao, Xiangjia Zhu , Fei Xu

Journal: Cell Discov .

PubMed ID: 38182578

Doi: s41421-023-00627-y

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Synovial sarcoma X breakpoint 1 protein uses a cryptic groove to selectively recognize H2AK119Ub nucleosomes

Authors: Zebin Tong , Huasong Ai, Ziyu Xu , Kezhang He , Guo-Chao Chu, Qiang Shi , Zhiheng Deng, Qiaomei Xue , Maoshen Sun, Yunxiang Du , Lujun Liang, Jia-Bin Li , Man Pan , Lei Liu

Journal: Nat Struct Mol Biol .

PubMed ID: 38177667

Doi: 10.1038/s41594-023-01141-1

Products & Services: Protein Electrophoresis and Western Gene Synthesis

Regulation of RAS palmitoyltransferases by accessory proteins and palmitoylation

Authors: Anlan Yang , Shengjie Liu , Yuqi Zhang , Jia Chen , Yujing Fan , Fengxiang Wang , Yilong Zou , Shan Feng , Jianping Wu , Qi Hu

Journal: Nat Struct Mol Biol .

PubMed ID: 38182928

Doi: 10.1038/s41594-023-01183-5

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Lipopolysaccharides from a Shiraia fruiting body-associated bacterium elicit host fungal hypocrellin A biosynthesis through nitric oxide generation

Authors: Xin Ping Li , Wen Hao Shen , Lu Lu Zhou , Qun Yan Huang , Rui Peng Cong , Li Ping Zheng , Jian Wen Wang

Journal: Carbohydr Polym .

PubMed ID: 37985049

Doi: 10.1016/j.carbpol.2023.121498.

Products & Services: Protein and Antibody Isolation

Inhaled nanoparticles for treating idiopathic pulmonary fibrosis by inhibiting honeycomb cyst and alveoli interstitium remodeling

Authors: Meng-Meng Han , Ling Tang , Bin Huang , Xue-Na Li , Yue-Fei Fang , Liang Qi , Bo-Wen Duan , Ya-Ting Yao , Yu-Jing He , Lei Xing , Hu-Lin Jiang

Journal: J Control Release .

PubMed ID: 38242209

Doi: 10.1016/j.jconrel.2024.01.032

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LL‐37_Renalexin hybrid peptide exhibits antimicrobial activity at lower MICs than its counterpart single peptides

Authors: Julius Kwesi Narh , Nestor G Casillas-Vega , Xristo Zarate

Journal: Appl Microbiol Biotechnol .

PubMed ID: 38229302

Doi: 10.1007/s00253-023-12887-5

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Remodelling the inguinal adipose sensory system to switch on the furnace: Electroacupuncture stimulation induces brown adipose thermogenesis

Authors: Mengjiang Lu , Ziwei Yu , Xingyu Yang , Li An , Xinyue Jing , Tiancheng Xu , Mengqian Yuan , Bin Xu , Zhi Yu

Journal: Diabetes Obes Metab .

PubMed ID: 38229447

Doi: 10.1111/dom.15444

Products & Services: Protein Electrophoresis and Western

ETHYLENE RESPONSE FACTOR 070 inhibits flowering in Pak-choi by indirectly impairing BcLEAFY expression

Authors: Zhanghong Yu , Xiaoshan Chen , Yan Li , Sayyed Hamad Ahmad Shah , Dong Xiao , Jianjun Wang , Xilin Hou , Tongkun Liu , Ying Li

Journal: Plant Physiol .

PubMed ID: 38269601

Doi: 10.1093/plphys/kiae021

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High-Yield Expression and Purification of Scygonadin, an Antimicrobial Peptide, Using the Small Metal-Binding Protein SmbP

Authors: Jessica J. Gomez-Lugo 1 , Nestor G. Casillas-Vega , Alma Gomez-Loredo , Isaias Balderas-Renteria and Xristo Zarate

Journal: Microorganisms

Doi: 10.3390/microorganisms12020278

Products & Services: Gene Synthesis

IGF-I protects porcine granulosa cells from hypoxia-induced apoptosis by promoting homologous recombination repair through the PI3K/AKT/E2F8/RAD51 pathway

Authors: Zhaojun Liu, Chungang Feng, Chengyu Li, Tong He, Gang Wu, Chen Fu, Hongmin Li, Ming Shen, Honglin Liu

Journal: FASEB J

PubMed ID: 38095232

Doi: 10.1096/fj.202301464R

Products & Services: Protein and Antibody Isolation

CI:Mor interactions in the lysogeny switches of TP901-1 and φ13 bacteriophages

Authors: Anders K Varming, Zhiyu Huang, Ghofran M Hamad, Kim K Rasmussen, Hanne Ingmer, Mogens Kilstrup, Leila Lo Leggio

Journal: Microbiome Res Rep

PubMed ID: 38841409

Doi: 10.20517/mrr.2023.50

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Engineering of Ogataea polymorpha strains with ability for high-temperature alcoholic fermentation of cellobiose

Authors: Roksolana Vasylyshyn, Olena Dmytruk, Andriy Sybirnyy, Justyna Ruchała

Journal: FEMS Yeast Res

PubMed ID: 38400543

Doi: 10.1093/femsyr/foae007

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Multidimensional Optimization of for Carotenoid Overproduction

Authors: Jian Fan, Yang Zhang, Wenhao Li, Zhizhen Li, Danli Zhang, Qiwen Mo, Mingfeng Cao, Jifeng Yuan

Journal: Biodes Res

PubMed ID: 38213763

Doi: 10.34133/bdr.0026

Products & Services: PCR Cloning and Subcloning

Complement receptor 1 is the human erythrocyte receptor for erythrocyte binding protein

Authors: Seong-Kyun Lee, Cécile Crosnier, Paola Carolina Valenzuela-Leon, Brian L P Dizon, John P Atkinson, Jianbing Mu, Gavin J Wright, Eric Calvo, Karthigayan Gunalan, Louis H Miller

Journal: Proc Natl Acad Sci U S A

PubMed ID: 38261617

Doi: 10.1073/pnas.2316304121

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Cell death induced by nicotine in human neuroblastoma SH-SY5Y cells is mainly attributed to cytoplasmic vacuolation originating from the trans-Golgi network

Authors: Jun Li, Hongjuan Wang, Huan Chen, Xiao Li, Yong Liu, Hongwei Hou, Qingyuan Hu

Journal: Food Chem Toxicol

PubMed ID: 38176581

Doi: 10.1016/j.fct.2023.114431

Products & Services: Protein Electrophoresis and Western

FLUAV RAM-IGIP: A modified live influenza virus vaccine that enhances humoral and mucosal responses against influenza

Authors: C Joaquín Cáceres, L Claire Gay, Aarti Jain, Teresa D Mejías, Matias Cardenas, Brittany Seibert, Flavio Cargnin Faccin, Brianna Cowan, Ginger Geiger, Amy Vincent Baker, Silvia Carnaccini, D Huw Davies, Daniela S Rajao, Daniel R Perez

Journal: biorxiv

PubMed ID: 38328128

Doi: 10.1101/2024.01.23.576908

Products & Services: PCR Cloning and Subcloning

Assessment of the effectiveness of the peptide inhibitor homologous to the transforming growth factor β cytokine blocking the TGFβRI/TGFβRII receptor complex-pilot study

Authors: Marynowski Mateusz, Karbownik Michał Seweryn, Szemraj Janusz, Kuna Piotr, Michał Gabriel Panek

Journal: Clin Transl Allergy

PubMed ID: 38282199

Doi: 10.1002/clt2.12320

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A conserved protein inhibitor brings under check the activity of RNase E in cyanobacteria

Authors: Su-Juan Liu, Gui-Ming Lin, Yu-Qi Yuan, Wenli Chen, Ju-Yuan Zhang, Cheng-Cai Zhang

Journal: Nucleic Acids Res

PubMed ID: 38000383

Doi: 10.1093/nar/gkad1094

Products & Services: Protein and Antibody Isolation

The Development of a Rabies Virus-Vectored Vaccine against , Targeting BBI39

Authors: Shantel Rios, Bibek Bhattachan, Kruthi Vavilikolanu, Chrysoula Kitsou, Utpal Pal, Matthias J Schnell

Journal: Vaccines (Basel)

PubMed ID: 38250891

Doi: 10.3390/vaccines12010078

Products & Services: Recombinant Proteins

Structural, Biochemical, and Bioinformatic Basis for Identifying Radical SAM Cyclopropyl Synthases

Authors: Yi Lien, Jake C Lachowicz, Aigera Mendauletova, Cynthia Zizola, Thacien Ngendahimana, Anastasiia Kostenko, Sandra S Eaton, John A Latham, Tyler L Grove

Journal: ACS Chem Biol

PubMed ID: 38295270

Doi: 10.1021/acschembio.3c00583

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FLT3L-induced virtual memory CD8 T cells engage the immune system against tumors

Authors: Hsin-Fang Tu, Yu-Jui Kung, Ling Lim, Julia Tao, Ming-Hung Hu, Michelle Cheng, Deyin Xing, T C Wu, Chien-Fu Hung

Journal: J Biomed Sci

PubMed ID: 38287325

Doi: 10.1186/s12929-024-01006-9

Products & Services: PCR Cloning and Subcloning

factor H-binding proteins are not required for serum resistance and infection in mammals

Authors: Nicholas A Cramer, Kalya M Socarras, Joshua Earl, Garth D Ehrlich, Richard T Marconi

Journal: Infect Immun

PubMed ID: 38289123

Doi: 10.1128/iai.00529-23

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GhUBC10-2 mediates GhGSTU17 degradation to regulate salt tolerance in cotton (Gossypium hirsutum)

Authors: Yaru Sun, Zailong Tian, Dongyun Zuo, Qiaolian Wang, Guoli Song

Journal: Plant Cell Environ

PubMed ID: 38282268

Doi: 10.1111/pce.14839

Products & Services: PCR Cloning and Subcloning

Rescue of secretion of rare-disease-associated misfolded mutant glycoproteins in UGGT1 knock-out mammalian cells

Authors: Gabor Tax, Kevin P Guay, Ludovica Pantalone, Martina Ceci, Tatiana Soldà, Charlie J Hitchman, Johan C Hill, Snežana Vasiljević, Andrea Lia, Carlos P Modenutti, Kees R Straatman, Angelo Santino, Maurizio Molinari, Nicole Zitzmann, Daniel N Hebert, Pietro Roversi, Marco Trerotola

Journal: Traffic

PubMed ID: 38272446

Doi: 10.1111/tra.12927

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Human microbiota from drug-naive patients with obsessive-compulsive disorder drives behavioral symptoms and neuroinflammation via succinic acid in mice

Authors: Ying-Dan Zhang, Dong-Dong Shi, Bing-Bing Liao, Yi Li, Sen Zhang, Jian Gao, Liang-Jun Lin, Zhen Wang

Journal: Mol Psychiatry

PubMed ID: 38273106

Doi: 10.1038/s41380-024-02424-9

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Pharmacokinetic Analyses of a Lipid Nanoparticle-Encapsulated mRNA-Encoded Antibody against Rift Valley Fever Virus

Authors: Shuo Wang, Ziling Zhu, Jianmin Li

Journal: Mol Pharm

PubMed ID: 38295278

Doi: 10.1021/acs.molpharmaceut.3c01016

Products & Services: Protein Electrophoresis and Western

Affinity-assisted covalent self-assembly of PduQ-SpyTag and Nox-SpyCatcher to construct multi-enzyme complexes on the surface of magnetic microsphere modified with chelated Ni

Authors: Mianxing Luo, Meng Zhang, Changbiao Chi, Guo Chen

Journal: Int J Biol Macromol

PubMed ID: 38218263

Doi: 10.1016/j.ijbiomac.2024.129365

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Comparative Analysis of Two NNMT Bisubstrate Inhibitors through Chemoproteomic Studies: Uncovering the Role of Unconventional SAM Analogue Moiety for Improved Selectivity

Authors: Ying Meng, Iredia D Iyamu, Noha A M Ahmed, Rong Huang

Journal: ACS Chem Biol

PubMed ID: 38181447

Doi: 10.1021/acschembio.3c00531

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A novel strategy for an anti-idiotype vaccine: nanobody mimicking neutralization epitope of porcine circovirus type 2

Authors: Yingying Deng, Yamin Sheng, Guixi Zhang, Yani Sun, Lei Wang, Pinpin Ji, Jiahong Zhu, Gang Wang, Baoyuan Liu, En-Min Zhou, Xuehui Cai, Yabin Tu, Julian A Hiscox, James P Stewart, Yang Mu, Qin Zhao

Journal: J Virol

PubMed ID: 38271227

Doi: 10.1128/jvi.01650-23

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Improved detection sensitivity of anti-PRV variant antibodies through preparation of anti-gB and anti-gE monoclonal antibodies and development of blocking ELISAs

Authors: Zhenyang Guo, Hu Xu, Siyu Zhang, Haonan Kang, Chao Li, Qi Sun, Jing Zhao, Jinhao Li, Guohui Zhou, Qian Wang, Lirun Xiang, Yandong Tang, Huairan Liu, Chaoliang Leng, Tongqing An, Xuehui Cai, Zhijun Tian, Hongliang Zhang, Jinmei Peng

Journal: Int J Biol Macromol

PubMed ID: 38219937

Doi: 10.1016/j.ijbiomac.2024.129425

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Systemic effects of hypophosphatasia characterization of two novel variants in the gene

Authors: Luis Martínez-Heredia, Manuel Muñoz-Torres, Raquel Sanabria-de la Torre, Ángela Jiménez-Ortas, Francisco Andújar-Vera, Trinidad González-Cejudo, Victoria Contreras-Bolívar, Sheila González-Salvatierra, José María Gómez-Vida, Cristina García-Fontana, Beatriz García-Fontana

Journal: Front Endocrinol (Lausanne)

PubMed ID: 38234425

Doi: 10.3389/fendo.2023.1320516

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Transition Metal Ion FRET-Based Probe to Study Cu(II)-Mediated Amyloid- Ligand Binding

Authors: Ri Wu, Despoina Svingou, Jonas B Metternich, Lukas R Benzenberg, Renato Zenobi

Journal: J Am Chem Soc

PubMed ID: 38225538

Doi: 10.1021/jacs.3c11533

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Structural role of K224 in taniborbactam inhibition of NDM-1

Authors: Daisuke Ono, Maria F Mojica, Christopher R Bethel, Yoshikazu Ishii, Salvador I Drusin, Diego M Moreno, Alejandro J Vila, Robert A Bonomo

Journal: Antimicrob Agents Chemother

PubMed ID: 38174924

Doi: 10.1128/aac.01332-23

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Production of anti-human cannabinoid receptor 2 (CB2) monoclonal antibody using non-viral vector induced human CB2 expressing myeloma as an immunogen

Authors: Jindaphun Kanyaruck, Takheaw Nuchjira, Putpim Chaochetdhapada, Laopajon Witida, Kotemul Kamonporn, Chaiwut Ratthakorn, Pata Supansa, Kasinrerk Watchara

Journal: Asian Pac J Allergy Immunol

PubMed ID: 38183645

Doi: 10.12932/AP-020723-1646

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Effect of l-serine and magnesium ions on the functional properties of human phosphoserine phosphatase and its pathogenetic variants

Authors: Francesco Marchesani, Valeria Buoli Comani, Stefano Bruno, Andrea Mozzarelli, Mauro Carcelli, Loredano Pollegioni, Laura Caldinelli, Alessio Peracchi, Barbara Campanini

Journal: Biochim Biophys Acta Mol Basis Dis

PubMed ID: 38278334

Doi: 10.1016/j.bbadis.2024.167034

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