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Alternating Arenavirus Vector Immunization Generates Robust Polyfunctional Genotype Cross-Reactive Hepatitis B Virus-Specific CD8 T-Cell Responses and High Anti-Hepatitis B Surface Antigen Titers

Authors: Sarah Schmidt, Meron Mengistu, Stephane Daffis, Sarah Ahmadi-Erber, Daniela Deutschmann, Tetiana Grigoriev, Ruth Chu, Cleo Leung, Adrian Tomkinson, Mohammad Nizam Uddin, Safiehkhatoon Moshkani, Michael D Robek, Jason Perry, Henning Lauterbach, Klaus Orlinger, Simon P Fletcher, Scott Balsitis

Journal: J Infect Dis

PubMed ID: 37602681

Doi: 10.1093/infdis/jiad340

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LINC02605 involved in paediatric Mycoplasma pneumoniae pneumonia complicated with diarrhoea via miR-539-5p/CXCL1 axis

Authors: Yang Zhang, Zeming Wu

Journal: Eur J Clin Invest

PubMed ID: 38662581

Doi: 10.1111/eci.14234

Products & Services: PCR Cloning and Subcloning

Structural basis of human Na15 gating mechanisms

Authors: Krishna Chinthalapudi, Rupam Biswas, Ana López-Serrano, Hsiang-Ling Huang, Angelina Ramirez-Navarro, Giovanna Grandinetti, Sarah Heissler, Isabelle Deschênes

Journal: Res Sq

PubMed ID: 38659812

Doi: 10.21203/rs.3.rs-3985999/v1

Products & Services: Molecular Biology Reagents

Saccharomyces cerevisiae cellular engineering for the production of FAME biodiesel

Authors: Laiyou Wang, Bingbing Liu, Qingshan Meng, Chunchun Yang, Yiyi Hu, Chunyan Wang, Pengyu Wu, Chen Ruan, Wenhuan Li, Shuang Cheng, Shuxian Guo

Journal: AMB Express

PubMed ID: 38658521

Doi: 10.1186/s13568-024-01702-7

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Co-delivery of Cas9 mRNA and guide RNAs for editing of LGMN gene represses breast cancer cell metastasis

Authors: Yue Wang, Yatu Peng, Guanghui Zi, Jin Chen, Baowei Peng

Journal: Sci Rep

PubMed ID: 38582932

Doi: 10.1038/s41598-024-58765-6

Products & Services: Protein and Antibody Isolation

CoCas9 is a compact nuclease from the human microbiome for efficient and precise genome editing

Authors: Eleonora Pedrazzoli, Michele Demozzi, Elisabetta Visentin, Matteo Ciciani, Ilaria Bonuzzi, Laura Pezzè, Lorenzo Lucchetta, Giulia Maule, Simone Amistadi, Federica Esposito, Mariangela Lupo, Annarita Miccio, Alberto Auricchio, Antonio Casini, Nicola Segata, Anna Cereseto

Journal: Nat Commun

PubMed ID: 38658578

Doi: 10.1038/s41467-024-47800-9

Products & Services: CRISPR RNAs/Cas9 Proteins(INACTIVE)

Transcription factor Nrf1 regulates proteotoxic stress-induced autophagy

Authors: Madison A Ward, Janakiram R Vangala, Hatem Elif Kamber Kaya, Holly A Byers, Nayyerehalsadat Hosseini, Antonio Diaz, Ana Maria Cuervo, Susmita Kaushik, Senthil K Radhakrishnan

Journal: J Cell Biol

PubMed ID: 38656405

Doi: 10.1083/jcb.202306150

Products & Services: Molecular Biology Reagents

Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation

Authors: Miko aj S abicki; Jiho Park; Rados aw P. Nowak; Shourya S. Roy Burman; Jesse Pellman; Charles Zou; Hlib Razumkov; Jeannie Carreiro; Simran Rastogi; Anna Goldstein; Marek M. Nagiec; Katherine A. Donovan; Jianwei Che; Moritz Hunkeler; Qixiang Geng; Chi-Lin Hsu; Megha Lakshminarayan; Chelsea Shu; Rebecca L. Zon; Zuzanna Kozicka; Paul M.C. Park; Jonathan M. Tsai; Hojong Yoon; Lyn H. Jones; Adam S. Sperling; Nathanael S. Gray; Eric S. Fischer; Benjamin L. Ebert

Journal: Molecular Cell

PubMed ID: 40845806

Doi: 10.1016/j.molcel.2025.07.019

Decoding the blueprint of receptor binding by filoviruses through large-scale binding assays and machine learning

Authors: Gorka Lasso; Michael Grodus; Estefania Valencia; Veronica DeJesus; Eliza Liang; Isabel Delwel; Rob H. Bortz; Dmitry Lupyan; Hanna Y. Ehrlich; Adrian A. Castellanos; Andrea Gazzo; Heather L. Wells; Supaporn Wacharapluesadee; Alexandre Tremeau-Bravard; Janine F.R. Seetahal; Tom Hughes; Jimmy Lee; Mei-Ho Lee; Anna R. Sjodin; Marike Geldenhuys; Marinda Mortlock; Isamara Navarrete-Macias; Kirsten Gilardi; Michael R. Willig; Alessandra F.D. Nava; Elisabeth H. Loh; Makda Asrat; Tierra Smiley-Evans; Walter S. Magesa; Sijali Zikankuba; David Wolking; Gerardo Suz n; Rafael Ojeda-Flores; Christine V.F. Carrington; Ariful Islam; Jonathan H. Epstein; Wanda Markotter; Christine K. Johnson; Tracey Goldstein; Barbara A. Han; Jonna A.K. Mazet; Rohit K. Jangra; Kartik Chandran; Simon J. Anthony

Journal: Cell Host & Microbe

PubMed ID: 39818205

Doi: 10.1016/j.chom.2024.12.016

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The Hsa_circ_0105558/miR-182-5p/ATF6 Cascade Affects HO-Triggered Oxidative Damage and Apoptosis of Human Lens Epithelial Cells

Authors: Wei Mao, Zhe Zhang

Journal: Biochem Genet

PubMed ID: 38530576

Doi: 10.1007/s10528-024-10753-1

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Diagnosis of fasciolosis antibodies in Brazilian cattle through ELISA employing both native and recombinant antigens

Authors: Guilherme Drescher, Hellen Geremias Dos Santos, Mariane Marques da Guarda Pinto, Luis Gustavo Morello, Fabiano Borges Figueiredo

Journal: Microbiol Spectr

PubMed ID: 38534120

Doi: 10.1128/spectrum.00095-24

Products & Services: Molecular Biology Reagents

Structural insights into human EMC and its interaction with VDAC

Authors: Mingyue Li, Chunli Zhang, Yuntao Xu, Shaobai Li, Chenhui Huang, Jian Wu, Ming Lei

Journal: Aging (Albany NY)

PubMed ID: 38517390

Doi: 10.18632/aging.205660

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Fibrinogen deposition promotes neuroinflammation and fibrin-derived γ peptide ameliorates neurological deficits after ischemic stroke

Authors: Lu Han, Yaying Song, Weiwei Xiang, Ze Wang, Yishu Wang, Xiajun Zhou, De-Sheng Zhu, Yangtai Guan

Journal: Int Immunopharmacol

PubMed ID: 38489969

Doi: 10.1016/j.intimp.2024.111831

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A Novel Polymer Nanoparticle Polydimethyl Diallyl Ammonium Chloride as An Adjuvant Enhances the Immune Response of SARS-CoV-2 Subunit Vaccine

Authors: Lili Ren, Chengcheng Ouyang, Shuqing Zhao, Qiqi Zheng, Weilu Guo, Baochao Fan, Jinzhu Zhou, Wei Zhang, Mi Hu, Jizong Li, Bin Li

Journal: Adv Healthc Mater

PubMed ID: 38436662

Doi: 10.1002/adhm.202304575

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Hepcidin contributes to largemouth bass (Micropterus salmoides) against bacterial infections

Authors: Weixiang Zhang, Bo Li, Ruying Yu, Wenyan Xu, Xiaoling Liu, Jianguo Su, Gailing Yuan

Journal: Int J Biol Macromol

PubMed ID: 38556234

Doi: 10.1016/j.ijbiomac.2024.131144

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Separation and purification of short-, medium-, and long-stranded RNAs by RP-HPLC using different mobile phases and C columns with various pore sizes

Authors: Makoto Ozaki, Tomomi Kuwayama, Motoshi Shimotsuma, Tsunehisa Hirose

Journal: Anal Methods

PubMed ID: 38445900

Doi: 10.1039/d4ay00114a

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Immunoprotective effect and mechanism of rEgP29 against CD4 T cell-deficient mice with infection

Authors: Ming Li, Yazhou Zhu, Zihua Li, Jiahui Song, Wei Zhao

Journal: Acta Biochim Biophys Sin (Shanghai)

PubMed ID: 38151996

Doi: 10.3724/abbs.2023282

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Structural insights into peptidoglycan glycosidase EtgA binding to the inner rod protein EscI of the type III secretion system via a designed EscI-EtgA fusion protein

Authors: J Boorman, X Zeng, J Lin, F van den Akker

Journal: Protein Sci

PubMed ID: 38380768

Doi: 10.1002/pro.4930

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Computational aptamer design for spike glycoprotein (S) (SARS CoV-2) detection with an electrochemical aptasensor

Authors: Alessia Cossettini, Laura Pasquardini, Antonello Romani, Aldo Feriani, Debora Pinamonti, Marisa Manzano

Journal: Appl Microbiol Biotechnol

PubMed ID: 38470514

Doi: 10.1007/s00253-024-13066-w

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Exploring the enigmatic association between PNLIP variants and risk of chronic pancreatitis in a large Chinese cohort

Authors: Brett M Cassidy, Fei Jiang, Jianguo Lin, Jian-Min Chen, Grace E Curry, Guo-Xiu Ma, Steven J Wilhelm, Shun-Jiang Deng, Guoying Zhu, Zhuan Liao, Mark E Lowe, Xunjun K Xiao, Wen-Bin Zou

Journal: Pancreatology

PubMed ID: 38485544

Doi: 10.1016/j.pan.2024.03.002

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WDR4 promotes HCC pathogenesis through N-methylguanosine by regulating and interacting with METTL1

Authors: Rui Dong, Chuanxu Wang, Bo Tang, Yayu Cheng, Xuehui Peng, Xiaomin Yang, Bing Ni, Jing Li

Journal: Cell Signal

PubMed ID: 38493882

Doi: 10.1016/j.cellsig.2024.111145

Products & Services: Protein and Antibody Isolation

Cross-reactive CD8 T cell responses to tumor-associated antigens (TAAs) and homologous microbiota-derived antigens (MoAs)

Authors: Beatrice Cavalluzzo, Marie Christine Viuff, Siri Amanda Tvingsholm, Concetta Ragone, Carmen Manolio, Angela Mauriello, Franco M Buonaguro, Maria Lina Tornesello, Francesco Izzo, Alessandro Morabito, Sine Reker Hadrup, Maria Tagliamonte, Luigi Buonaguro

Journal: J Exp Clin Cancer Res

PubMed ID: 38509571

Doi: 10.1186/s13046-024-03004-z

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Inhibitory effects of senkyuchachosan on SARS-CoV-2 papain-like protease activity in vitro

Authors: Yuka Kiba, Takashi Tanikawa, Tsuyoshi Hayashi, Takami Yokogawa, Aiko Sano, Ryuichiro Suzuki, Masashi Kitamura

Journal: J Nat Med

PubMed ID: 38512650

Doi: 10.1007/s11418-024-01788-0

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A distinct tumor microenvironment makes anaplastic thyroid cancer more lethal but immunotherapy sensitive than papillary thyroid cancer

Authors: Pei-Zhen Han, Wei-Dong Ye, Peng-Cheng Yu, Li-Cheng Tan, Xiao Shi, Xu-Feng Chen, Cong He, Jia-Qian Hu, Wen-Jun Wei, Zhong-Wu Lu, Ning Qu, Yu Wang, Qing-Hai Ji, Dong-Mei Ji, Yu-Long Wang

Journal: JCI Insight

PubMed ID: 38478516

Doi: 10.1172/jci.insight.173712

Products & Services: Molecular Biology Reagents

Structurally Diverse Bisbenzylisoquinoline Alkaloids with Antiadipogenic Activity through Downregulation from the Embryo of Seeds

Authors: Peiliang Zhang, Jiadong Li, Jiyao Shi, Zhihong Cheng, Tao Wu

Journal: J Nat Prod

PubMed ID: 38483204

Doi: 10.1021/acs.jnatprod.3c01290

Products & Services: Protein and Antibody Isolation

Effects of Drag-Reducing Polymers on Hemodynamics and Whole Blood-Endothelial Interactions in 3D-Printed Vascular Topologies

Authors: Louis S Paone, Matthew Szkolnicki, Brandon J DeOre, Kiet A Tran, Noah Goldman, Allison M Andrews, Servio H Ramirez, Peter A Galie

Journal: ACS Appl Mater Interfaces

PubMed ID: 38488736

Doi: 10.1021/acsami.3c17099

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The Novel MFG-E8-derived Oligopeptide, MOP3, Improves Outcomes in a Preclinical Murine Model of Neonatal Sepsis

Authors: Colleen P Nofi, Jose M Prince, Monowar Aziz, Ping Wang

Journal: J Pediatr Surg

PubMed ID: 38582704

Doi: 10.1016/j.jpedsurg.2024.03.025

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LINC00869 Promotes Hepatocellular Carcinoma Metastasis via Protrusion Formation

Authors: Xiaowen Shao, Yamei Dang, Tingting Zhang, Nan Bai, Jianing Huang, Mengya Guo, Li Sun, Minghe Li, Xiao Sun, Xinran Zhang, Feng Han, Ning Zhang, Hao Zhuang, Yongmei Li

Journal: Mol Cancer Res

PubMed ID: 37934195

Doi: 10.1158/1541-7786.MCR-23-0414

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Integrative analysis of metabolism subtypes and identification of prognostic metabolism-related genes for glioblastoma

Authors: Jiahui Li, Yutian Wei, Jiali Liu, Shupeng Cheng, Xia Zhang, Huaide Qiu, Jianan Li, Chuan He

Journal: Biosci Rep

PubMed ID: 38419527

Doi: 10.1042/BSR20231400

Products & Services: PCR Cloning and Subcloning

Development and Evaluation of an Immunoinformatics-Based Multi-Peptide Vaccine against Infection

Authors: Sean Jeffreys, Megan P Tompkins, Jadelynn Aki, Sara B Papp, James P Chambers, M Neal Guentzel, Chiung-Yu Hung, Jieh-Juen Yu, Bernard P Arulanandam

Journal: Vaccines (Basel)

PubMed ID: 38675740

Doi: 10.3390/vaccines12040358

Products & Services: Molecular Biology Reagents

A T cell-based SARS-CoV-2 spike protein vaccine provides protection without antibodies

Authors: Juan Shi, Jian Zheng, Xiujuan Zhang, Wanbo Tai, Ryan Compas, Jack Deno, Natalie Jachym, Abhishek K Verma, Gang Wang, Xiaoqing Guan, Abby E Odle, Yushun Wan, Fang Li, Stanley Perlman, Liang Qiao, Lanying Du

Journal: JCI Insight

PubMed ID: 38456504

Doi: 10.1172/jci.insight.155789

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Genetically Encoded XTEN-based Hydrogels with Tunable Viscoelasticity and Biodegradability for Injectable Cell Therapies

Authors: Jennifer I Bennett, Mary O'Kelly Boit, Nicole E Gregorio, Fan Zhang, Ryan D Kibler, Jack W Hoye, Olivia Prado, Peter B Rapp, Charles E Murry, Kelly R Stevens, Cole A DeForest

Journal: Adv Sci (Weinh)

PubMed ID: 38477407

Doi: 10.1002/advs.202301708

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Characterization of Probiotic Properties and Whole-Genome Analysis of N5 and N7 Isolated from Swine

Authors: Kun Wang, Yu Wang, Lifang Gu, Jinyan Yu, Qianwen Liu, Ruiqi Zhang, Guixin Liang, Huan Chen, Fang Gu, Haoyu Liu, Xin'an Jiao, Yunzeng Zhang

Journal: Microorganisms

PubMed ID: 38674616

Doi: 10.3390/microorganisms12040672

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Preparation and immunogenicity evaluation of C-HapS-P6 fusion protein vaccine against nontypeable Haemophilus influenzae in mice

Authors: Nan Hu, Weifeng Li, Zihong Zhao, Yueli Chang, Cai Wang, Yutuo Zhang

Journal: Int J Med Microbiol

PubMed ID: 38461565

Doi: 10.1016/j.ijmm.2024.151616

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Copine proteins are required for brassinosteroid signaling in maize and Arabidopsis

Authors: Teng Jing, Yuying Wu, Yanwen Yu, Jiankun Li, Xiaohuan Mu, Liping Xu, Xi Wang, Guang Qi, Jihua Tang, Daowen Wang, Shuhua Yang, Jian Hua, Mingyue Gou

Journal: Nat Commun

PubMed ID: 38459051

Doi: 10.1038/s41467-024-46289-6

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Expression, purification, and biological activity evaluation of cathepsin L in mammalian cells

Authors: Wenwen Zhou, Baoqing You, Yifan Zheng, Shuyi Si, Yan Li, Jing Zhang

Journal: Biosci Biotechnol Biochem

PubMed ID: 38271604

Doi: 10.1093/bbb/zbae005

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Activation of Piezo1 increases the sensitivity of breast cancer to hyperthermia therapy

Authors: Shao-Kang Wang, Xiao-Ting Zhang, Xuan-Yao Jiang, Bi-Jiang Geng, Tao-Lin Qing, Lei Li, Yun Chen, Jin-Feng Li, Xiao-Fang Zhang, Shuo-Gui Xu, Jiang-Bo Zhu, Yu-Ping Zhu, Mei-Tang Wang, Ji-Kuai Chen

Journal: Open Med (Wars)

PubMed ID: 38463518

Doi: 10.1515/med-2024-0898

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Phenotypic characterization of sorghum seedlings and expression patterns of SNAC1 and DREB1A genes under water‑stress: an insight towards developing resilient cultivars

Authors: David Adedayo Animasaun · Khadijat Adetoun Adedoyin · Afeez Taiwo Bakare · Kabir Adeniran Mustapha · Mary Anuoluwapo Akinbobola · Kafayat Folasade Awujoola · Jonathan Toyin Ogunjobi

Journal: springerlink

Doi: 10.1007/s10722-024-01956-x

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Decoding chromatin states by proteomic profiling of nucleosome readers

Authors: Saulius Lukauskas, Andrey Tvardovskiy, Nhuong V Nguyen , Mara Stadler, Peter Faull, Tina Ravnsborg, Bihter Özdemir Aygenli, Scarlett Dornauer, Helen Flynn, Rik G H Lindeboom, Teresa K Barth, Kevin Brockers, Stefanie M Hauck, Michiel Vermeulen, Ambrosius P Snijders, Christian L Müller, Peter A DiMaggio, Ole N Jensen, Robert Schneider, Till Bartke

Journal: Nature

PubMed ID: 38448585

Doi: 10.1038/s41586-024-07141-5

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Alternative low-populated conformations prompt phase transitions in polyalanine repeat expansions

Authors: Rosa Antón, Miguel Á Treviño, David Pantoja-Uceda, Sara Félix, María Babu, Eurico J Cabrita, Markus Zweckstetter, Philip Tinnefeld, Andrés M Vera, Javier Oroz

Journal: Nature

PubMed ID: 38431667

Doi: 10.1038/s41467-024-46236-5

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Filamentous fungus-produced human monoclonal antibody provides protection against SARS-CoV-2 in hamster and non-human primate models

Authors: Franziska K Kaiser, Mariana Gonzalez Hernandez, Nadine Krüger, Ellinor Englund, Wenjuan Du, Anna Z Mykytyn, Mathijs P Raadsen, Mart M Lamers

Journal: Nature Communications

PubMed ID: 38485931

Doi: 10.1038/s41467-024-46443-0

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Human IgG Fc-engineering for enhanced plasma half-life, mucosal distribution and killing of cancer cells and bacteria

Authors: Stian Foss , Siri A Sakya, Leire Aguinagalde, Marta Lustig, Jutamas Shaughnessy, Ana Rita Cruz , Lisette Scheepmaker, Line Mathiesen, Fulgencio Ruso-Julve, Aina Karen Anthi, Torleif Tollefsrud Gjølberg

Journal: Nature Communications

PubMed ID: 38453922

Doi: 10.1038/s41467-024-46321-9

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An alphacoronavirus polymerase structure reveals conserved replication factor functions

Authors: Thomas K Anderson, Peter J Hoferle, Kennan J Chojnacki, Kenneth W Lee, Joshua J Coon, Robert N Kirchdoerfer

Journal: Nucleic Acids Research

PubMed ID: 38442273

Doi: 10.1093/nar/gkae153

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Determinants of CRISPR Cas12a nuclease activation by DNA and RNA targets

Authors: Eric A Nalefski, Remy M Kooistra, Ishira Parikh, Samantha Hedley, Karunya Rajaraman, Damian Madan

Journal: Nucleic Acids Research

PubMed ID: 38477377

Doi: 10.1093/nar/gkae152

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Application of Recombinant Lactic Acid Bacteria (LAB) Live Vector Oral Vaccine in the Prevention of F4+ Enterotoxigenic

Authors: Jiangxu Yu, Jiyang Fu, Hongshuo Liu, Chao Kang, Zesong Wang, Yancheng Jin, Shuxuan Wu, Tianzhi Li, Ruicheng Yang, Meilin Jin, Huanchun Chen, Xiangru Wang

Journal: Vaccines (Basel)

PubMed ID: 38543938

Doi: 10.3390/vaccines12030304

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EGFR amplification and EGFRvIII predict and participate in TAT-Cx43266-283 antitumor response in preclinical glioblastoma models

Authors: Andrea Álvarez-Vázquez, Laura San-Segundo, Pilar Cerveró-García, Raquel Flores-Hernández, Claudia Ollauri-Ibáñez, Berta Segura-Collar, C G Hubert, Gillian Morrison, Steven M Pollard, Justin D Lathia, Pilar Sánchez-Gómez, Arantxa Tabernero

Journal: Neuro Oncol

PubMed ID: 38507464

Doi: 10.1093/neuonc/noae060

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Dual mechanisms contribute to enhanced voltage dependence of an electric fish potassium channel

Authors: Jelena Todorovic, Immani Swapna, Antonio Suma, Vincenzo Carnevale, Harold Zakon

Journal: Biophys J

PubMed ID: 38429925

Doi: 10.1016/j.bpj.2024.02.028

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Antigenicity, epitope mapping, and intracellular distribution of the NSP7α protein of porcine reproductive and respiratory syndrome virus

Authors: Tao Wang, Da-Song Xia, Xiao-Xiao Tian, Yong-Bo Yang, Tong-Qing An

Journal: Int J Biol Macromol

PubMed ID: 38493809

Doi: 10.1016/j.ijbiomac.2024.130944

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Engineering a Lactobacillus Lysine Riboswitch to Dynamically Control Metabolic Pathways for Lysine Production in

Authors: Qingwei Jiang, Feng Geng, Juan Shen, Ping Zhu, Zhaoxin Lu, Libang Zhou, Fengxia Lu

Journal: Microorganisms

PubMed ID: 38543657

Doi: 10.3390/microorganisms12030606

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Safety and Immunogenicity of a Messenger RNA-Based Cytomegalovirus Vaccine in Healthy Adults: Results From a Phase 1, Randomized, Clinical Trial

Authors: Carlos Fierro, Daniel Brune, Marian Shaw, Howard Schwartz, Conor Knightly, Jiang Lin, Andrea Carfi, Andrew Natenshon, Shiva Kalidindi, Caroline Reuter, Jacqueline Miller, Lori Panther

Journal: J Infect Dis

PubMed ID: 38478705

Doi: 10.1093/infdis/jiae114

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