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Immunogenicity of Mix-and-Match CoronaVac/BNT162b2 Regimen versus Homologous CoronaVac/CoronaVac Vaccination: A Single-Blinded, Randomized, Parallel Group Superiority Trial

Authors: Samar Samoud, Jihene Bettaieb, Mariem Gdoura, Ghassen Kharroubi, Feriel Ben Ghachem, Imen Zamali, Ahlem Ben Hmid, Sadok Salem, Ahmed Adel Gereisha, Mongi Dellagi, Nahed Hogga, Adel Gharbi, Amor Baccouche, Manel Gharbi, Chadha Khemissi, Ghada Akili, Wissem Slama, Nabila Chaieb, Yousr Galai, Hechmi Louzir, Henda Triki, Melika Ben Ahmed

Journal: Vaccines (Basel)

PubMed ID: 37631897

Doi: 10.3390/vaccines11081329

Products & Services: Monoclonal Antibody Services

Structure and mechanism of a neuropeptide-activated channel in the ENaC/DEG superfamily

Authors: Fenglian Liu, Yu Dang, Lu Li, Hao Feng, Jianlin Li, Haowei Wang, Xu Zhang, Zhe Zhang, Sheng Ye, Yutao Tian, Qingfeng Chen

Journal: Nat Chem Biol

PubMed ID: 37550431

Doi: 10.1038/s41589-023-01401-7

Products & Services: Peptide Synthesis

Intracerebral Hemorrhage-Induced Brain Injury: the Role of Lysosomal-Associated Transmembrane Protein 5

Authors: Wei Hua, Shuainan Ma, Yuxin Pang, Qi Liu, Yueying Wang, Zhiyi Liu, Nan Zhao, Naixin Ren, Sinan Jin, Benshuai Wang, Yuejia Song, Jiping Qi

Journal: Mol Neurobiol

PubMed ID: 37525083

Doi: 10.1007/s12035-023-03484-8

Products & Services: Molecular Biology Reagents

Photoexcited cryptochromes interact with ADA2b and SMC5 to promote the repair of DNA double-strand breaks in Arabidopsis

Authors: Tongtong Guo, Minqing Liu, Li Chen, Yao Liu, Ling Li, Yupeng Li, Xiaoli Cao, Zhilei Mao, Wenxiu Wang, Hong-Quan Yang

Journal: Nat Plants

PubMed ID: 37488265

Doi: 10.1038/s41477-023-01461-6

Products & Services: Proteins, Expression, Isolation and Analysis

Centrosome amplification and aneuploidy driven by the HIV-1-induced Vpr•VprBP•Plk4 complex in CD4 T cells

Authors: Jung-Eun Park, Tae-Sung Kim, Yan Zeng, Christina M Monnie, Muhammad S Alam, Ming Zhou, Melissa Mikolaj, Frank Maldarelli, Kedar Narayan, Jinwoo Ahn, Jonathan D Ashwell, Klaus Strebel, Kyung S Lee

Journal: Res Sq

PubMed ID: 37645926

Doi: 10.21203/rs.3.rs-2924123/v1

Products & Services: DNA Sequencing

Vav1-dependent Rac1 activation mediates hypoxia-induced gemcitabine resistance in pancreatic ductal adenocarcinoma cells through upregulation of HIF-1α expression

Authors: Congyuan Zhu, Hao Hu, Ye Ma, Shuming Xiong, Dongming Zhu

Journal: Cell Biol Int

PubMed ID: 37545183

Doi: 10.1002/cbin.12074

Products & Services: Molecular Biology Reagents

Structural and functional insights into the modulation of T cell costimulation by monkeypox virus protein M2

Authors: Shangyu Yang , Yong Wang , Feiyang Yu , Rao Cheng , Yiwei Zhang , Dan Zhou , Xuanxiu Ren , Zengqin Deng , Haiyan Zhao

Journal: Nature Communications

PubMed ID: 37626059

Doi: 10.1038/s41467-023-40748-2

Products & Services: Proteins, Expression, Isolation and Analysis

Novel tripeptide RKH derived from Akkermansia muciniphila protects against lethal sepsis

Authors: Shihao Xie , Jiaxin Li , Fengyuan Lyu , Qingming Xiong , Peng Gu , Yuqi Chen , Meiling Chen , Jingna Bao , Xianglong Zhang , Rongjuan Wei , Youpeng Deng , Hongzheng Wang , Zhenhua Zeng , Zhongqing Chen , Yongqiang Deng , Zhuoshi Lian , Jie Zhao , Wei Gong , Ye Chen , Ke-Xuan Liu , Yi Duan , Yong Jiang , Hong-Wei Zhou , Peng Chen

Journal: Gut .

PubMed ID: 37553229

Doi: 10.1136/gutjnl-2023-329996

Products & Services: Peptide Synthesis

Crystal structure of domain of unknown function 507 (DUF507) reveals a new protein fold

Authors: Cole E McKay , Jianlin Cheng , John J Tanner

Journal: Sci Rep .

PubMed ID: 37596303

Doi: 10.1038/s41598-023-40558-y

Products & Services: Gene Synthesis

Author Correction: mRNA-LNP expressing PfCSP and Pfs25 vaccine candidates targeting infection and transmission of Plasmodium falciparum

Authors: Clifford T H Hayashi, Yi Cao, Leor C Clark, Abhai K Tripathi, Fidel Zavala, Garima Dwivedi, James Knox, Mohamad-Gabriel Alameh, Paulo J C Lin, Ying K Tam, Drew Weissman, Nirbhay Kumar

Journal: npj Vaccines

PubMed ID: 37567884

Doi: 10.1038/s41541-023-00723-w

Products & Services: Molecular Biology Reagents

Structure/epitope analysis and IgE binding activities of three cyclophilin family proteins from Dermatophagoides pteronyssinus

Authors: Yuwei Li, Xizhuo Sun, Liteng Yang

Journal: Sci Rep

PubMed ID: 37604978

Doi: 10.1038/s41598-023-40720-6

Products & Services: Molecular Biology Reagents

Two granzyme A/K homologs in Zebra mbuna have different specificities, one classical tryptase and one with chymase activity

Authors: Erdem Aybay, Mamoun Elkhalifa, Srinivas Akula, Sara Wernersson, Lars Hellman

Journal: Dev Comp Immunol

PubMed ID: 37597699

Doi: 10.1016/j.dci.2023.104920

Products & Services: Molecular Biology Reagents

SMC3 epigenetic silencing regulates Rab27a expression and drives pancreatic cancer progression

Authors: Nuno Bastos, Stéphanie A Castaldo, Bárbara Adem, José C Machado, Carlos A Melo, Sonia A Melo

Journal: J Transl Med

PubMed ID: 37641131

Doi: 10.1186/s12967-023-04448-1

Products & Services: Molecular Biology Reagents

TRIB1 confers therapeutic resistance in GBM cells by activating the ERK and Akt pathways

Authors: Karnika Singh, Chunhua Han, Jessica L Fleming, Aline P Becker, Joseph McElroy, Tiantian Cui, Benjamin Johnson, Ashok Kumar, Ebin Sebastian, Christian A Showalter, Morgan S Schrock, Matthew K Summers, Valesio Becker, Zhen-Yue Tong, Xiaomei Meng, Heather R Manring, Monica Venere, Erica H Bell, Pierre A Robe, A L Grosu, S Jaharul Haque, Arnab Chakravarti

Journal: Sci Rep

PubMed ID: 37528172

Doi: 10.1038/s41598-023-32983-w

Products & Services: DNA Sequencing

Organelle-dependent polyprotein designs enable stoichiometric expression of nitrogen fixation components targeted to mitochondria

Authors: Jianguo Yang, Nan Xiang, Yiheng Liu, Chenyue Guo, Chenyu Li, Hui Li, Shuyi Cai, Ray Dixon, Yi-Ping Wang

Journal: Proc Natl Acad Sci U S A

PubMed ID: 37585462

Doi: 10.1073/pnas.2305142120

Products & Services: Gene Synthesis

Secreted Peptide SpPIP1 Modulates Disease Resistance and Salt Tolerance in Tomato

Authors: Ruirui Yang , Zhicheng Wang , Lei Zhao , Jie Liu , Jun Meng , Yushi Luan

Journal: J Agric Food Chem .

PubMed ID: 37535837

Doi: 10.1021/acs.jafc.3c03412

Products & Services: Peptide Synthesis

Inactivation influences the extent of inhibition of voltage-gated Ca channels by Gem-implications for channelopathies

Authors: Salma Allam, Rose Levenson-Palmer, Zuleen Chia Chang, Sukhjinder Kaur, Bryan Cernuda, Ananya Raman, Audrey Booth, Scott Dobbins, Gabrielle Suppa, Jian Yang, Zafir Buraei

Journal: Front Physiol

PubMed ID: 37654674

Doi: 10.3389/fphys.2023.1155976

Products & Services: Proteins, Expression, Isolation and Analysis

In Vitro and Ex Planta Gold-Bonded and Gold-Mineralized Tobacco Mosaic Virus

Authors: Yifeng Ma, Zhuohong Wu, Nicole F Steinmetz

Journal: Langmuir

PubMed ID: 37540623

Doi: 10.1021/acs.langmuir.3c00688

Products & Services: Peptide Synthesis

Vaccination with the Crimean-Congo hemorrhagic fever virus viral replicon vaccine induces NP-based T-cell activation and antibodies possessing Fc-mediated effector functions

Authors: F E M Scholte, E Karaaslan, T J O'Neal, T E Sorvillo, S C Genzer, S R Welch, J D Coleman-McCray, J R Spengler, M H Kainulainen, J M Montgomery, S D Pegan, E Bergeron, C F Spiropoulou

Journal: Front Cell Infect Microbiol

PubMed ID: 37671145

Doi: 10.3389/fcimb.2023.1233148

Products & Services: Peptide Synthesis

Riding the Omicron BA5 Wave: Improved Humoral Response after Vaccination with Bivalent Omicron BA4-5-Adapted mRNA SARS-CoV-2 Vaccine in Chronic Hemodialysis Patients

Authors: Eugen Ovcar, Sammy Patyna, Niko Kohmer, Elisabeth Heckel-Kratz, Sandra Ciesek, Holger F Rabenau, Ingeborg A Hauser, Kirsten de Groot

Journal: Vaccines (Basel)

PubMed ID: 37766105

Doi: 10.3390/vaccines11091428

Products & Services: Molecular Biology Reagents

Mutations in CCNB3 affect its location thus causing a multiplicity of phenotypes in human oocytes maturation by aberrant CDK1 activity and APC/C activity at different stages

Authors: Congjing Wang, Meng Xi Chen, Yuan Zhang, Xue Bai, Qiqi Cao, Jian Han, Nana Zhang, Chun Zhao, Xiufeng Ling, Ximan Rui, Yichun Guan, Junqiang Zhang, Ran Huo

Journal: J Ovarian Res

PubMed ID: 37635245

Doi: 10.1186/s13048-023-01229-8

Products & Services: Molecular Biology Reagents

mRNA vaccination boosts S-specific T cell memory and promotes expansion of CD45RA T-like CD8 T cells in COVID-19 recovered individuals

Authors: Koshlan Mayer-Blackwell, Heeju Ryu, Amy S Codd, K Rachael Parks, Hugh R MacMillan, Kristen W Cohen, Terri L Stewart, Aaron Seese, Maria P Lemos, Stephen C De Rosa, Julie L Czartoski, Zoe Moodie, Long T Nguyen, Donald J McGuire, Rafi Ahmed, Andrew Fiore-Gartland, M Juliana McElrath, Evan W Newell

Journal: Cell Rep Med

PubMed ID: 37552991

Doi: 10.1016/j.xcrm.2023.101149

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Development of a novel ultrasound- and biocrosslinking-enhanced immobilization strategy with application to food enzymes

Authors: Juan Han , Ting Zhang , Zhuoyue Zhou , Houjin Zhang

Journal: Food Chem .

PubMed ID: 36917903

Doi: 10.1016/j.foodchem.2023.135810

Products & Services: Proteins, Expression, Isolation and Analysis

Publisher Correction: High-throughput characterization of HLA-E-presented CD94/NKG2x ligands reveals peptides which modulate NK cell activation

Authors: Brooke D Huisman, Ning Guan, Timo Rückert, Lee Garner, Nishant K Singh, Andrew J McMichael, Geraldine M Gillespie, Chiara Romagnani, Michael E Birnbaum

Journal: Nat Commun

PubMed ID: 37644057

Doi: 10.1038/s41467-023-40946-y

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Microbe-induced gene silencing boosts crop protection against soil-borne fungal pathogens

Authors: Han-Guang Wen, Jian-Hua Zhao, Bo-Sen Zhang, Feng Gao, Xue-Ming Wu, Yong-Sheng Yan, Jie Zhang, Hui-Shan Guo

Journal: Nat Plants

PubMed ID: 37653339

Doi: 10.1038/s41477-023-01507-9

Products & Services: Custom DNA/RNA Oligos

Effectiveness of Bivalent Omicron-Containing Booster Vaccines against SARS-CoV-2 Omicron Variant among Individuals with and without Prior SARS-CoV-2 Infection

Authors: Kristin Widyasari, Jieun Jang, Taejoon Kang, Sunjoo Kim

Journal: Viruses

PubMed ID: 37632098

Doi: 10.3390/v15081756

Products & Services: Monoclonal Antibody Services

RhoB promotes Salmonella survival by regulating autophagy

Authors: Marco Kirchenwitz, Jessica Halfen, Kristin von Peinen, Silvia Prettin, Jana Kollasser, Susanne Zur Lage, Wulf Blankenfeldt, Cord Brakebusch, Klemens Rottner, Anika Steffen, Theresia E B Stradal

Journal: Eur J Cell Biol

PubMed ID: 37703749

Doi: 10.1016/j.ejcb.2023.151358

Products & Services: Proteins, Expression, Isolation and Analysis

GmNAC039 and GmNAC018 activate the expression of cysteine protease genes to promote soybean nodule senescence

Authors: Haixiang Yu, Aifang Xiao, Jiashan Wu, Haoxing Li, Yan Duan, Qingshan Chen, Hui Zhu, Yangrong Cao

Journal: Plant Cell

PubMed ID: 37177994

Doi: 10.1093/plcell/koad129

Products & Services: Proteins, Expression, Isolation and Analysis

Anti-Melanogenic and Antioxidant Activity of Bifidobacterium longum Strain ZJ1 Extracts, Isolated from a Chinese Centenarian

Authors: Jing Wu , Funa Zhang , Haixia Yu , Shimei Qi , Yu Wu , Weihua Xiao

Journal: Int J Mol Sci .

PubMed ID: 37628988

Doi: 10.3390/ijms241612810

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Design, synthesis and evaluation of ursodeoxycholic acid-cinnamic acid hybrids as potential anti-inflammatory agents by inhibiting Akt/NF-κB and MAPK signaling pathways

Authors: Xiaoxue Li, Yue Hu, Bingxin He, Lingyu Li, Yu Tian, Yingjie Xiao, Hai Shang, Zhongmei Zou

Journal: Eur J Med Chem

PubMed ID: 37678142

Doi: 10.1016/j.ejmech.2023.115785

Products & Services: Proteins, Expression, Isolation and Analysis

Recombinant spike protein vaccines coupled with adjuvants that have different modes of action induce protective immunity against SARS-CoV-2

Authors: Shiho Chiba, Peter J Halfmann, Shun Iida, Yuichiro Hirata, Yuko Sato, Makoto Kuroda, Tammy Armbrust, Samuel Spyra, Tadaki Suzuki, Yoshihiro Kawaoka

Journal: Vaccine

PubMed ID: 37635002

Doi: 10.1016/j.vaccine.2023.08.054

Products & Services: Peptide Synthesis

Homozygous COQ7 mutation: a new cause of potentially treatable distal hereditary motor neuropathy

Authors: Arnaud Jacquier, Julian Theuriet, Fanny Fontaine, Valentine Mosbach, Nicolas Lacoste, Shams Ribault, Valérie Risson, Julien Carras, Laurent Coudert, Thomas Simonet, Philippe Latour, Tanya Stojkovic, Juliette Piard, Anne Cosson, Gaëtan Lesca, Françoise Bouhour, Stéphane Allouche, Hélène Puccio, Antoine Pegat, Laurent Schaeffer

Journal: Brain

PubMed ID: 36454683

Doi: 10.1093/brain/awac453

Products & Services: Gene Synthesis

Optimization and Deoptimization of Codons in SARS-CoV-2 and Related Implications for Vaccine Development

Authors: Xinkai Wu, Ke-Jia Shan, Fuwen Zan, Xiaolu Tang, Zhaohui Qian, Jian Lu

Journal: Adv Sci (Weinh) .

PubMed ID: 37267926

Doi: 10.3390/v16020223

Products & Services: Gene Synthesis

Target delivery of a PD-1-TREM2 scFv by CAR-T cells enhances anti-tumor efficacy in colorectal cancer

Authors: Jian Chen, Tianchuan Zhu, Guanmin Jiang, Qi Zeng, Zhijian Li, Xi Huang

Journal: Mol Cancer

PubMed ID: 37563723

Doi: 10.1186/s12943-023-01830-x

Products & Services: Gene Synthesis

Mechanosensitive accumulation of non-muscle myosin IIB during mitosis requires its translocation activity

Authors: Chao Wang , Jingjing Ding , Qiaodong Wei , Shoukang Du , Xiaobo Gong , Ting Gang Chew

Journal: iScience .

PubMed ID: 37720093

Doi: 10.1016/j.isci.2023.107773

Products & Services: Proteins, Expression, Isolation and Analysis

Using a synthetic machinery to improve carbon yield with acetylphosphate as the core

Authors: Likun Guo , Min Liu , Yujia Bi , Qingsheng Qi, Mo Xian , Guang Zhao

Journal: Nat Commun .

PubMed ID: 37648707

Doi: 10.1038/s41467-023-41135-7

Products & Services: Codon Optimization

Novel "GaEl Antigenic Patches" Identified by a "Reverse Epitomics" Approach to Design Multipatch Vaccines against NIPAH Infection, a Silent Threat to Global Human Health

Authors: Sukrit Srivastava, Michael Kolbe

Journal: ACS Omega

PubMed ID: 37692250

Doi: 10.1021/acsomega.3c01909

Products & Services: Proteins, Expression, Isolation and Analysis

Peripheral substitution effects on unnatural base pairs: A case of brominated TPT3 to enhance replication fidelity

Authors: Bianbian Huo, Chao Wang, Xiaoqi Hu, Honglei Wang, Gongming Zhu, Anlian Zhu, Lingjun Li

Journal: Bioorg Chem

PubMed ID: 37683537

Doi: 10.1016/j.bioorg.2023.106827

Products & Services: Proteins, Expression, Isolation and Analysis

Context-dependent role of Pho binding sites in Polycomb complex recruitment in Drosophila

Authors: Janet Lesley Brown, Joshua D Price, Maksim Erokhin, Judith A Kassis

Journal: Genetics

PubMed ID: 37216193

Doi: 10.1093/genetics/iyad096

Products & Services: Proteins, Expression, Isolation and Analysis

Immunogenicity, safety and reactogenicity of heterologous (third dose) booster vaccination with a full or fractional dose of two different COVID-19 vaccines: A phase 4, single-blind, randomized controlled trial in adults

Authors: Sue Ann Costa Clemens, Natalie Marchevsky, Sarah Kelly, Sally Felle, Ahmed Eldawi, Rupetha Rajasingam, Rawan Mahmud, Teresa Lambe, Merryn Voysey, Isabela Gonzalez, Eveline Pipolo Milan, Maria Cleonice Justino, Sagida Bibi, Parvinder Aley, Ralf Clemens, Andrew J Pollard

Journal: Hum Vaccin Immunother

PubMed ID: 37438960

Doi: 10.1080/21645515.2023.2233400

Products & Services: Proteins, Expression, Isolation and Analysis

Photoaffinity labelling displacement assay using multiple recombinant protein domains

Authors: David J Fallon, Alex Phillipou, Christopher J Schofield, David House, Nicholas C O Tomkinson, Jacob T Bush

Journal: Biochem J

PubMed ID: 37401534

Doi: 10.1042/BCJ20230129

Products & Services: Proteins, Expression, Isolation and Analysis

Directed evolution rice genes with randomly multiplexed sgRNAs assembly of base editors

Authors: Ao Zhang, Tiaofeng Shan, Yan Sun, Zhipeng Chen, Jianjian Hu, Zhichao Hu, Ziheng Ming, Zhitao Zhu, Xue Li, Jun He, Shijia Liu, Ling Jiang, Xiaoou Dong, Yufeng Wu, Yanpeng Wang, Yuqiang Liu, Chao Li, Jianmin Wan

Journal: Plant Biotechnol J

PubMed ID: 37571976

Doi: 10.1111/pbi.14156

Products & Services: Proteins, Expression, Isolation and Analysis

Modified mRNA Formulation and Stability for Cardiac and Skeletal Muscle Delivery

Authors: Magdalena M Żak, Keerat Kaur, Jimeen Yoo, Ann Anu Kurian, Matthew Adjmi, Gayatri Mainkar, Seonghun Yoon, Lior Zangi

Journal: Pharmaceutics

PubMed ID: 37765147

Doi: 10.3390/pharmaceutics15092176

Products & Services: Molecular Biology Reagents

A Systematic Survey of Reversibly Covalent Dipeptidyl Inhibitors of the SARS-CoV-2 Main Protease

Authors: Zhi Zachary Geng, Sandeep Atla, Namir Shaabani, Veerabhadra Vulupala, Kai S Yang, Yugendar R Alugubelli, Kaustav Khatua, Peng-Hsun Chen, Jing Xiao, Lauren R Blankenship, Xinyu R Ma, Erol C Vatansever, Chia-Chuan D Cho, Yuying Ma, Robert Allen, Henry Ji, Shiqing Xu, Wenshe Ray Liu

Journal: J Med Chem

PubMed ID: 37561993

Doi: 10.1021/acs.jmedchem.3c00221

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Structural basis for cross-group recognition of an influenza virus hemagglutinin antibody that targets postfusion stabilized epitope

Authors: Keisuke Tonouchi, Yu Adachi, Tateki Suzuki, Daisuke Kuroda, Ayae Nishiyama, Kohei Yumoto, Haruko Takeyama, Tadaki Suzuki, Takao Hashiguchi, Yoshimasa Takahashi

Journal: PLoS Pathog

PubMed ID: 37556494

Doi: 10.1371/journal.ppat.1011554

Products & Services: Peptide Synthesis

Optimization of an alum-anchored clinical HIV vaccine candidate

Authors: Kristen A Rodrigues, Christopher A Cottrell, Jon M Steichen, Bettina Groschel, Wuhbet Abraham, Heikyung Suh, Yash Agarwal, Kaiyuan Ni, Jason Y H Chang, Parisa Yousefpour, Mariane B Melo, William R Schief, Darrell J Irvine

Journal: npj Vaccines

PubMed ID: 37573422

Doi: 10.1038/s41541-023-00711-0

Products & Services: Recombinant Proteins

Evaluating the effect of food components on the digestion of dietary nucleic acids in human gastric juice in vitro

Authors: Yanfang Zhang, Jingyi Dong, Jingxian Chen, Xiaoming Pan

Journal: Food Sci Nutr

PubMed ID: 37823154

Doi: 10.1002/fsn3.3599

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Toward non-factor therapy in hemophilia: an antithrombin insensitive Gla-domainless factor Xa as tissue factor pathway inhibitor bait

Authors: Marie-Claire Dagher, Atanur Ersayin, Landry Seyve, Mathieu Castellan, Cyril Moreau, Luc Choisnard, Nicole Thielens, Raphaël Marlu, Benoît Polack, Aline Thomas

Journal: Res Pract Thromb Haemost

PubMed ID: 37841511

Doi: 10.1016/j.rpth.2023.102175

Products & Services: Combinatorial DNA Libraries

Immobilization of α-transglucosidase on silica-coated magnetic nanoparticles and its application for production of isomaltooligosaccharide from the potato peel

Authors: Rohit Maurya, Usman Ali, Sunaina Kaul, Raja Bhaiyya, Ravindra Pal Singh, Koushik Mazumder

Journal: Sci Rep

PubMed ID: 37543692

Doi: 10.1038/s41598-023-38266-8

Products & Services: Molecular Biology Reagents

CircMIB2 therapy can effectively treat pathogenic infection by encoding a novel protein

Authors: Weiwei Zheng, Linchao Wang, Shang Geng, Liyuan Yang, Xing Lv, Shiying Xin, Tianjun Xu

Journal: Cell Death Dis

PubMed ID: 37652905

Doi: 10.1038/s41419-023-06105-3

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