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Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers

Authors: Stephane Ferretti, Jacques Hamon, Ruben de Kanter, Clemens Scheufler，Henrik Möbitz, Marta Cortés-Cros

Journal: Nature

PubMed ID: 38658754

Doi: 10.1038/s41586-024-07350-y

Products & Services: CRISPR RNAs/Cas9 Proteins(INACTIVE)

Transcription bodies regulate gene expression by sequestering CDK9

Authors: Martino Ugolini, Maciej A Kerlin, Ksenia Kuznetsova, Haruka Oda, Hiroshi Kimura, Nadine L Vastenhouw

Journal: Nature Cell Biology

PubMed ID: 38589534

Doi: 10.1038/s41556-024-01389-9

Products & Services: Custom DNA/RNA Oligos

Fuzzy recognition by the prokaryotic transcription factor HigA2 from Vibrio cholerae

Authors: San Hadži, Zala Živič , Matic Kovačič , Uroš Zavrtanik , Sarah Haeserts, Daniel Charlier, Janez Plavec, Alexander N Volkov, Jurij Lah, Remy Loris

Journal: Nature Communications

PubMed ID: 38600130

Doi: 10.1038/s41467-024-47296-3

Products & Services: PCR Cloning and Subcloning

Structural basis for dimerization of a paramyxovirus polymerase complex

Authors: Jin Xie, Mohamed Ouizougun-Oubari, Li Wang, Guanglei Zhai, Daitze Wu, Zhaohu Lin, Manfu Wang, Barbara Ludeke, Xiaodong Yan, Tobias Nilsson, Lu Gao, Xinyi Huang, Rachel Fearns, Shuai Chen

Journal: Nature Communications

PubMed ID: 38605025

Doi: 10.1038/s41467-024-47470-7

Products & Services: Protein and Antibody Isolation

SARS-CoV-2 nsp15 preferentially degrades AU-rich dsRNA via its dsRNA nickase activity

Authors: Xionglue Wang, Bin Zhu

Journal: Nucleic Acids Res

PubMed ID: 38634805

Doi: 10.1093/nar/gkae290

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RBM22 regulates RNA polymerase II 5' pausing, elongation rate, and termination by coordinating 7SK-P-TEFb complex and SPT5

Authors: Xian Du, Wenying Qin, Chunyu Yang, Lin Dai, Mingkui San, Yingdan Xia, Siyu Zhou, Mengyang Wang, Shuang Wu, Shaorui Zhang, Huiting Zhou, Fangshu Li, Fang He, Jingfeng Tang, Jia-Yu Chen, Yu Zhou, Rui Xiao

Journal: Genome Biology

PubMed ID: 38641822

Doi: 10.1186/s13059-024-03242-6

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Oncolytic adenovirus encoding apolipoprotein A1 suppresses metastasis of triple-negative breast cancer in mice

Authors: Jie Dong, Lingkai Kong, Shiqun Wang, Mao Xia, Yenan Zhang, Jingyi Wu, Fuming Yang, Shuguang Zuo, Jiwu Wei

Journal: Experimental & Clinical Cancer Research

PubMed ID: 38566092

Doi: 10.1186/s13046-024-03011-0

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The DEAD-box ATPase Dbp10/DDX54 initiates peptidyl transferase center formation during 60S ribosome biogenesis

Authors: Victor E Cruz, Christine S Weirich, Nagesh Peddada, Jan P Erzberger

Journal: Nat Commun

PubMed ID: 38632236

Doi: 10.1038/s41467-024-47616-7

Products & Services: Gene Synthesis

A rational designed multi-epitope vaccine elicited robust protective efficacy against Klebsiella pneumoniae lung infection

Authors: Jingwen Liao, Xiaoli Zhang, Xi Zeng, Zhuo Zhao, Tianjun Sun, Zhenping Xia, Haiming Jing, Yue Yuan, Zhifu Chen, Qiang Gou, Liqun Zhao, Weijun Zhang, Quanming Zou, Jinyong Zhang

Journal: Biomed Pharmacother

PubMed ID: 38643540

Doi: 10.1016/j.biopha.2024.116611

Products & Services: Molecular Biology Reagents

Characterization of an O-Specific Glycosyltransferase Involved in Flagellin Glycosylation

Authors: Daisuke Fujinami, Ayumi Mizui, Azusa Miyata, Sohei Ito

Journal: ACS Chem Biol

PubMed ID: 38562012

Doi: 10.1021/acschembio.4c00045

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Kirigami-inspired artificial spidroin microneedles for wound patches

Authors: Yongji Xiong, Yue Xu, Baoyang Lin, Bingfang He, Bingbing Gao

Journal: Int J Biol Macromol

PubMed ID: 38663709

Doi: 10.1016/j.ijbiomac.2024.131838

Products & Services: Protein and Antibody Isolation

The Role of Fatty Acid Synthase in the Vascular Smooth Muscle Cell to Foam Cell Transition

Authors: Bethany J Bogan, Holly C Williams, Claire M Holden, Vraj Patel, Giji Joseph, Christopher Fierro, Hugo Sepulveda, W Robert Taylor, Amir Rezvan, Alejandra San Martin

Journal: Cells

PubMed ID: 38667273

Doi: 10.3390/cells13080658

Products & Services: Protein and Antibody Isolation

Identification, Expression and Evolutional Analysis of Two Genes in Amphioxus

Authors: Yajun Wang, Jingyuan Lin, Wenjin Li, Guangdong Ji, Zhenhui Liu

Journal: Animals (Basel)

PubMed ID: 38672288

Doi: 10.3390/ani14081140

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Identification of IGF2 promotes skin wound healing by co-expression analysis

Authors: Xingyan Liu, Ying Teng, Huan Li, Ding Luo, Hongkun Li, Jinghan Shen, Simin Du, Yuyue Zhang, Dali Wang, Jie Jing

Journal: Int Wound J

PubMed ID: 38572823

Doi: 10.1111/iwj.14862

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Hypoxic dental pulp stem cells-released succinate promotes osteoclastogenesis and root resorption

Authors: Andi Yang, Jinmeng Wang, Zhiyu Yang, Lulu Wang, Houxuan Li, Lang Lei

Journal: Int J Med Sci

PubMed ID: 38774749

Doi: 10.7150/ijms.94972

Products & Services: Gene Synthesis

A Rationally Designed Synthetic Antiviral Peptide Binder Targeting the Receptor-Binding Domain of SARS-CoV-2

Authors: Lalita Mohan Behera, Pulkit Kr Gupta, Manaswini Ghosh, Sucharita Shadangi, Soumendra Rana

Journal: J Phys Chem B

PubMed ID: 38657271

Doi: 10.1021/acs.jpcb.4c00241

Products & Services: Protein and Antibody Isolation

Evolutionary analysis reveals the origin of sodium coupling in glutamate transporters

Authors: Krishna D Reddy, Burha Rasool, Farideh Badichi Akher, Nemanja Kutlešić, Swati Pant, Olga Boudker

Journal: biorxiv

PubMed ID: 38106174

Doi: 10.1101/2023.12.03.569786

Products & Services: Gene Synthesis

Establishment and application of a gold nanoparticle-based immunochromatographic test strip for the detection of avian leukosis virus P27 antigen in egg white samples

Authors: Chunhao Wei, Hua Kuang, Xinxin Xu, Lingling Guo, Aihua Qu, Aihong Wu, Chuanlai Xu, Liqiang Liu

Journal: Analyst

PubMed ID: 38563739

Doi: 10.1039/d4an00180j

Products & Services: Protein and Antibody Isolation

Unlocking the distinctive enzymatic functions of the early plant biomass deconstructive genes in a brown rot fungus by cell-free protein expression

Authors: Jesus D Castaño, Irina V El Khoury, Joshua Goering, James E Evans, Jiwei Zhang

Journal: Appl Environ Microbiol

PubMed ID: 38567954

Doi: 10.1128/aem.00122-24

Products & Services: Gene Synthesis

Heterogeneous and Cooperative Rupture of Histidine-Ni Metal-Coordination Bonds on Rationally Designed Protein Templates

Authors: Eesha Khare, Constancio Gonzalez Obeso, Zaira Martín-Moldes, Ayesha Talib, David L Kaplan, Niels Holten-Andersen, Kerstin G Blank, Markus J Buehler

Journal: ACS Biomater Sci Eng

PubMed ID: 38669114

Doi: 10.1021/acsbiomaterials.3c01819

Products & Services: Gene Synthesis

Seroevidence of SARS-CoV-2 spillback to rodents in Sarawak, Malaysian Borneo

Authors: Cheng Siang Tan, Madinah Adrus, Sultana Parvin Habeebur Rahman, Haziq Izzuddin Muhamad Azman, Riz Anasthasia Alta Abang

Journal: BMC Vet Res

PubMed ID: 38678268

Doi: 10.1186/s12917-024-03892-5

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FGF7 enhances the expression of ACE2 in human islet organoids aggravating SARS-CoV-2 infection

Authors: Hao Meng, Zhiying Liao, Yanting Ji, Dong Wang, Yang Han, Chaolin Huang, Xujuan Hu, Jingyi Chen, Hengrui Zhang, Zonghong Li, Changliang Wang, Hui Sun, Jiaqi Sun, Lihua Chen, Jiaxiang Yin, Jincun Zhao, Tao Xu, Huisheng Liu

Journal: Signal Transduct Target Ther

PubMed ID: 38654010

Doi: 10.1038/s41392-024-01790-8

Products & Services: Protein and Antibody Isolation

The impact of glycosylation on the structure, function, and interactions of CD14

Authors: Jon Imanol Quintana, Sandra Delgado, Miriam Rábano, Mikel Azkargorta, Mirane Florencio-Zabaleta, Luca Unione, Maria dM Vivanco, Félix Elortza, Jesús Jiménez-Barbero, Ana Ardá

Journal: Glycobiology

PubMed ID: 38227775

Doi: 10.1093/glycob/cwae002

Products & Services: Molecular Biology Reagents

Protocol to identify flavonoid antagonists of the SARS-CoV-2 main protease

Authors: Moua Yang, Lin Lin, Robert Flaumenhaft

Journal: STAR Protoc

PubMed ID: 38583157

Doi: 10.1016/j.xpro.2024.102990

Products & Services: Protein and Antibody Isolation

Engineered Luminescent Oncolytic Vaccinia Virus Activation of Photodynamic-Immune Combination Therapy for Colorectal Cancer

Authors: Lu-Yi Ye, Yi-Shu Li, Tong Ge, Long-Cai Liu, Jing-Xing Si, Xue Yang, Wei-Jiao Fan, Xiao-Zhen Liu, You-Ni Zhang, Jun-Wei Wang, Shi-Bing Wang, Hai Zou, Yue-Liang Zheng, Ke-Tao Jin, Zheng-Wei Mao, Yu Cai, Xiao-Zhou Mou

Journal: Adv Healthc Mater

PubMed ID: 38551143

Doi: 10.1002/adhm.202304136

Products & Services: Gene Synthesis

Identification and characterization of emGalaseE, a β-1,4 galactosidase from Elizabethkingia meningoseptica, and its application on living cell surface

Authors: Yongliang Tong, Xinrong Lu, Danfeng Shen, Lin Rao, Lin Zou, Shaoxian Lyu, Linlin Hou, Guiqin Sun, Li Chen

Journal: Biological Macromolecules

PubMed ID: 38657932

Doi: 10.1016/j.ijbiomac.2024.131766

Products & Services: Gene Synthesis

Protein language models-assisted optimization of a uracil-N-glycosylase variant enables programmable T-to-G and T-to-C base editing

Authors: Yan He, Xibin Zhou, Chong Chang, Ge Chen, Weikuan Liu, Geng Li, Xiaoqi Fan, Mingsun Sun, Chensi Miao, Qianyue Huang, Yunqing Ma, Fajie Yuan, Xing Chang

Journal: Mol Cell

PubMed ID: 38377993

Doi: 10.1016/j.molcel.2024.01.021

Products & Services: Synthetic Guide RNA

Measles Virus-Based Vaccine Expressing Membrane-Anchored Spike of SARS-CoV-2 Inducing Efficacious Systemic and Mucosal Humoral Immunity in Hamsters

Authors: Zhi-Hui Yang 1, Yan-Li Song 1, Jie Pei 1, Song-Zhuang Li 1, Rui-Lun Liu 1, Yu Xiong 1, Jie Wu 1, Yuan-Lang Liu 1, Hui-Fen Fan 1, Jia-Hui Wu 1, Ze-Jun Wang 1, Jing Guo 1, Sheng-Li Meng 1, Xiao-Qi Chen 1, Jia Lu 1, Shuo Shen 1

Journal: Viruses

PubMed ID: 38675901

Doi: 10.3390/v16040559

Products & Services: Molecular Biology Reagents

YeeD is an essential partner for YeeE-mediated thiosulfate uptake in bacteria and regulates thiosulfate ion decomposition

Authors: Mai Ikei, Ryoji Miyazaki, Keigo Monden, Yusuke Naito, Azusa Takeuchi, Yutaro S Takahashi, Yoshiki Tanaka, Keina Murata, Takaharu Mori, Muneyoshi Ichikawa, Tomoya Tsukazaki

Journal: PLoS Biol

PubMed ID: 38656967

Doi: 10.1371/journal.pbio.3002601

Products & Services: Gene Synthesis

Neutrophil proteases are protective against SARS-CoV-2 by degrading the spike protein and dampening virus-mediated inflammation

Authors: Nathan Gf Leborgne, Christelle Devisme, Nedim Kozarac, Inês Berenguer Veiga, Nadine Ebert, Aurélie Godel, Llorenç Grau-Roma, Melanie Scherer, Philippe Plattet, Volker Thiel, Gert Zimmer, Adriano Taddeo, Charaf Benarafa

Journal: JCI Insight

PubMed ID: 38470488

Doi: 10.1172/jci.insight.174133

Products & Services: Protein Electrophoresis and Western

Photodynamic therapy upregulates expression of HIF-1α and PD-L1 in related pathways and its clinical relevance in non-small-cell lung cancer

Authors: Wen Sun, Yuan Cheng, Xiaoyu Ma, Zhou Jin, Qi Zhang, Guangfa Wang

Journal: Eur J Med Res

PubMed ID: 38609977

Doi: 10.1186/s40001-024-01780-0

Products & Services: Molecular Biology Reagents

Bioinformatics, expression analysis, and functional verification of allene oxide synthase gene and in qingke

Authors: Likun An, Ziao Wang, Yongmei Cui, Youhua Yao, Yixiong Bai, Yuehai Liu, Xin Li, Xiaohua Yao, Kunlun Wu

Journal: Open Life Sci

PubMed ID: 38681731

Doi: 10.1515/biol-2022-0855

Products & Services: Protein and Antibody Isolation

Identification of distinct immune signatures in inclusion body myositis by peripheral blood immunophenotyping using machine learning models

Authors: Emily McLeish, Anuradha Sooda, Nataliya Slater, Kelly Beer, Ian Cooper, Frank L Mastaglia, Merrilee Needham, Jerome D Coudert

Journal: Clin Transl Immunology

PubMed ID: 38585335

Doi: 10.1002/cti2.1504

Products & Services: Protein and Antibody Isolation

The Y locus encodes a REPRESSOR OF PHOTOSYNTHETIC GENES protein that represses carotenoid biosynthesis via interaction with APRR2 in carrot

Authors: Ying-Gang Wang, Yu-Min Zhang, Ya-Hui Wang, Kai Zhang, Jing Ma, Jia-Xin Hang, Yu-Ting Su, Shan-Shan Tan, Hui Liu, Ai-Sheng Xiong, Zhi-Sheng Xu

Journal: Plant Cell

PubMed ID: 38593056

Doi: 10.1093/plcell/koae111

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Recombinant bivalent subunit vaccine combining truncated VP4 from P[7] and P[23] induces protective immunity against prevalent porcine rotaviruses

Authors: Xuechao Tang, Sufen Li, Jinzhu Zhou, Xianyu Bian, Jianxin Wang, Nan Han, Xuejiao Zhu, Ran Tao, Wei Wang, Min Sun, Peng Li, Xuehan Zhang, Bin Li

Journal: J Virol

PubMed ID: 38591886

Doi: 10.1128/jvi.00212-24

Products & Services: Molecular Biology Reagents

Proteolytic cleavage of the TGFβ co-receptor CD109 changes its conformation, resulting in protease inhibition via activation of its thiol ester, and dissociation from the cell membrane

Authors: Kathrine Tejlgård Jensen, Nadia Sukusu Nielsen, Ana Viana Almeida, Ida B Thøgersen, Jan J Enghild, Seandean Lykke Harwood

Journal: FEBS J

PubMed ID: 38587194

Doi: 10.1111/febs.17128

Products & Services: Gene Synthesis

Ultrastructural localization of Porphyromonas gingivalis gingipains in the substantia nigra of Parkinson's disease brains

Authors: Florian Ermini, Victoria F Low, Jennifer J Song, Adelie Y S Tan, Richard L M Faull, Michael Dragunow, Maurice A Curtis, Stephen S Dominy

Journal: NPJ Parkinsons Dis

PubMed ID: 38664405

Doi: 10.1038/s41531-024-00705-2

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Histone derived antimicrobial peptides identified from Mytilus coruscus serum by peptidomics

Authors: Haodong Wang, Zhi Liao, Zongxin Yang, Wenhui Xiao, Zilin Yang, Jianyu He, Xiaolin Zhang, Xiaojun Yan, Changsheng Tang

Journal: Fish Shellfish Immunol

PubMed ID: 38614412

Doi: 10.1016/j.fsi.2024.109546

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A highly efficient blocking ELISA based on p72 monoclonal antibody for the detection of African swine fever virus antibodies and identification of its linear B cell epitope

Authors: Weldu Tesfagaber, Wan Wang, Lulu Wang, Rui Zhao, Yuanmao Zhu, Fang Li, Encheng Sun, Renqiang Liu, Zhigao Bu, Geng Meng, Dongming Zhao

Journal: Int J Biol Macromol

PubMed ID: 38642684

Doi: 10.1016/j.ijbiomac.2024.131695

Products & Services: Recombinant Proteins

MEF2C contributes to axonal branching by regulating Kif2c transcription

Authors: Ronghua Wu, Ying Sun, Zhihao Zhou, Zhangji Dong, Yan Liu, Mei Liu, Huasong Gao

Journal: Eur J Neurosci

PubMed ID: 38663879

Doi: 10.1111/ejn.16344

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Water-deficit stress induces prenylated stilbenoid production and affects biomass in peanut hairy roots: Exploring the role of stilbenoid prenyltransferase downregulation

Authors: Gaurav Gajurel, Rokib Hasan, Fabricio Medina-Bolivar

Journal: Plant Physiol Biochem

PubMed ID: 38579541

Doi: 10.1016/j.plaphy.2024.108596

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RBM3 enhances the stability of MEF2C mRNA and modulates blood-brain barrier permeability in AD microenvironment

Authors: Ye Ding, Meiqing Lin, Jirui Wang, Xiuli Shang

Journal: Biochim Biophys Acta Mol Cell Res

PubMed ID: 38670534

Doi: 10.1016/j.bbamcr.2024.119738

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Identification of a circulating three-miRNA panel for the diagnosis of primary open angle glaucoma

Authors: Bo Qin, Li-Ping Li, Qing-Dan Xu, Yuan Lei, Yu-Hong Chen

Journal: Int Ophthalmol

PubMed ID: 38619629

Doi: 10.1007/s10792-024-03100-1

Products & Services: Protein and Antibody Isolation

Lipopolysaccharide modification enhances the inhibitory effect of clodronate liposomes on hepatic fibrosis by depletion of macrophages and hepatic stellate cells

Authors: Luyao Zhang, Min Tao, Hengyan Zhang, Shichao Zhang, Xiaojuan Hou, Chen Zong, Gangqi Sun, Shiyao Feng, Haixin Yan, Ying Lu, Xue Yang, Lixin Wei, Li Zhang

Journal: Chem Biol Interact

PubMed ID: 38663797

Doi: 10.1016/j.cbi.2024.111015

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Significant but partial lipoprotein lipase functional loss caused by a novel occurrence of rare LPL biallelic variants

Authors: Yuepeng Hu, Jian-Min Chen, Han Zuo, Na Pu, Guofu Zhang, Yichen Duan, Gang Li, Zhihui Tong, Weiqin Li, Baiqiang Li, Qi Yang

Journal: Lipids Health Dis

PubMed ID: 38561841

Doi: 10.1186/s12944-024-02086-0

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Diverse Class 2 CRISPR Effectors as Active Nucleases with Expanded Targeting Capabilities

Authors: Meng Wang, Lila Rieber, Jessica van Baaren, Meaghan Morgan, Stephanie Merrett, Ian McDowell, Tyson Bowen

Journal: CRISPR J

PubMed ID: 38635326

Doi: 10.1089/crispr.2023.0058

Products & Services: Codon Optimization

Identification of Enhanced Vaccine Mimotopes for the p15E Murine Cancer Antigen

Authors: Shiqi Zhou, Yiting Song, Yuan Luo, Breandan Quinn, Yang Jiao, Mark D Long, Scott I Abrams, Jonathan F Lovell

Journal: Cancer Res Commun

PubMed ID: 38506662

Doi: 10.1158/2767-9764.CRC-23-0384

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Deciphering the unique autoregulatory mechanisms and substrate specificity of the understudied DCLK3 kinase linked to neurodegenerative diseases

Authors: Jason D. Lu; Peng Zhao; Anup Prasad; Neha Gupta; Nathan Gravel; Tej Shidhaye; Lance Wells; Samiksha Katiyar; Natarajan Kannan

Journal: The Journal of Biological Chemistry

PubMed ID: 40902973

Doi: 10.1016/j.jbc.2025.110664

Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation

Authors: Miko aj S abicki; Jiho Park; Rados aw P. Nowak; Shourya S. Roy Burman; Jesse Pellman; Charles Zou; Hlib Razumkov; Jeannie Carreiro; Simran Rastogi; Anna Goldstein; Marek M. Nagiec; Katherine A. Donovan; Jianwei Che; Moritz Hunkeler; Qixiang Geng; Chi-Lin Hsu; Megha Lakshminarayan; Chelsea Shu; Rebecca L. Zon; Zuzanna Kozicka; Paul M.C. Park; Jonathan M. Tsai; Hojong Yoon; Lyn H. Jones; Adam S. Sperling; Nathanael S. Gray; Eric S. Fischer; Benjamin L. Ebert

Journal: Molecular Cell

PubMed ID: 40845806

Doi: 10.1016/j.molcel.2025.07.019

Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation

Journal: Molecular Cell

PubMed ID: 40845806

Doi: 10.1016/j.molcel.2025.07.019