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页码: 54/1030 每页显示数量
Author Correction: Host susceptibility and structural and immunological insight of S proteins of two SARS-CoV-2 closely related bat coronaviruses
Authors: Xiuyuan Ou, Ge Xu, Pei Li, Yan Liu, Fuwen Zan, Pan Liu, Jiaxin Hu, Xing Lu, Siwen Dong, Yao Zhou, Zhixia Mu, Zhiqiang Wu, Jianwei Wang, Qi Jin, Pinghuang Liu, Jian Lu, Xiangxi Wang, Zhaohui Qian
Journal: Cell Discov
PubMed ID: 37813850
Doi: 10.1038/s41421-023-00597-1
G-quadruplexes of KSHV oriLyt play important roles in promoting lytic DNA replication
Authors: Prerna Dabral, Timsy Uppal, Subhash C Verma
Journal: Microbiol Spectr
PubMed ID: 37800915
Doi: 10.1128/spectrum.05316-22
Expression of a SAG protein with a CAP domain from Eimeria necatrix and its role in invasion and immunoprotection
Authors: Feiyan Wang, Amin Zhang, Xuelian Fan, Qianqian Feng, Zhizhi Zhang, Dandan Liu, Shijie Su, Zhaofeng Hou, Jinjun Xu, Xilong Kang, Zhiming Pan, Hunjie Hu, Jianping Tao
Journal: Vet Parasitol
PubMed ID: 37931477
Doi: 10.1016/j.vetpar.2023.110060
Quercetin ameliorates ferroptosis of rat cardiomyocytes via activation of the SIRT1/p53/SLC7A11 signaling pathway to alleviate sepsis‑induced cardiomyopathy
Authors: Xin Lin, Xiaoxia Zhao, Qingfeng Chen, Xiaoyue Wang, Yongya Wu, Hao Zhao
Journal: Int J Mol Med
PubMed ID: 37859612
Doi: 10.3892/ijmm.2023.5319
Bispecific antibody shuttles targeting CD98hc mediate efficient and long-lived brain delivery of IgGs
Authors: Ghasidit Pornnoppadol, Layne G Bond, Michael J Lucas, Jennifer M Zupancic, Yun-Huai Kuo, Boya Zhang, Colin F Greineder, Peter M Tessier
Journal: Cell Chem Biol
PubMed ID: 37890480
Doi: 10.1016/j.chembiol.2023.09.008
Products & Services: Combinatorial DNA Libraries   
Evaluation of potential targets to enhance the sensitivity of cholangiocarcinoma cells to anticancer drugs
Authors: Paula Sanchon-Sanchez, Oscar Briz, Rocio I R Macias, Mar Abad, Anabel Sanchez-Martin, Jose J G Marin, Elisa Lozano
Journal: Biomed Pharmacother
PubMed ID: 37832404
Doi: 10.1016/j.biopha.2023.115658
Products & Services: Custom RNAi Services   
Chemoproteomic capture of RNA binding activity in living cells
Authors: Andrew J Heindel, Jeffrey W Brulet, Xiantao Wang, Michael W Founds, Adam H Libby, Dina L Bai, Michael C Lemke, David M Leace, Thurl E Harris, Markus Hafner, Ku-Lung Hsu
Journal: Nat Commun
PubMed ID: 37805600
Doi: 10.1038/s41467-023-41844-z
Products & Services: Mutant Libraries   
Investigation of Immunostimulatory Effects of IFN-γ Cytokine and CD40 Ligand Costimulatory Molecule for Development of HIV-1 Therapeutic Vaccine Candidate
Authors: Fatemeh Heidarnejad, Azam Bolhassani, Soheila Ajdary, Alireza Milani, Seyed Amir Sadeghi
Journal: Adv Biol (Weinh)
PubMed ID: 37840398
Doi: 10.1002/adbi.202300402
Products & Services: Molecular Biology Reagents   
Authentication of a lophotrochozoan adipokinetic hormone receptor in a Gastropod, Aplysia californica
Authors: Pei-San Tsai, Kelsey N Sanders, Xin Dai, David Plachetzki
Journal: Gen Comp Endocrinol
PubMed ID: 37865149
Doi: 10.1016/j.ygcen.2023.114393
Products & Services: Molecular Biology Reagents   
A non-canonical role of endothelin converting enzyme 1 (ECE1) in promoting lung cancer development via directly targeting protein kinase B (AKT)
Authors: Li Chen, Yikai Lu, Mengmeng Zhao, Junfang Xu, Yan Wang, Qinghua Xu, Yajuan Cao, Haipeng Liu
Journal: J Gene Med
PubMed ID: 37897251
Doi: 10.1002/jgm.3612
PTBP2 attenuation facilitates fibroblast to neuron conversion by promoting alternative splicing of neuronal genes
Authors: Binglin Zhu, Emily Fisher, Li Li, Ping Zhong, Zhen Yan, Jian Feng
Journal: Stem Cell Reports
PubMed ID: 37832540
Doi: 10.1016/j.stemcr.2023.09.012
Products & Services: Molecular Biology Reagents   
Nucleic-acid-triggered NADase activation of a short prokaryotic Argonaute
Authors: Xiaopan Gao, Kun Shang, Kaixiang Zhu, Linyue Wang, Zhixia Mu, Xingke Fu, Xia Yu, Bo Qin, Hongtao Zhu, Wei Ding, Sheng Cui
Journal: Nature
Doi: doi.org/10.1038/s41586-023-06665-6
Products & Services: Gene Synthesis   
Examining the Potential Formation of Ternary DNA Complexes with Chromium‑Cysteine, Chromium-Ascorbate, and Chromium-Glutathione and Implications for Their Carcinogenicity
Authors: Sydney Marchi , Emma Lankford , Bradley Dorin , Eilidh Drummond , Sumner C Thomas , Stephen A Woski , John B Vincent
Journal: Biol Trace Elem Res .
PubMed ID: 36662348
Doi: 10.1007/s12011-023-03573-8
Products & Services: Custom DNA/RNA Oligos   
Molecular basis of methyl-salicylate-mediated plant airborne defence
Authors: Qian Gong , Yunjing Wang , Linfang He , Fan Huang , Danfeng Zhang , Yan Wang , Xiang Wei , Meng Han , Haiteng Deng , Lan Luo , Feng Cui , Yiguo Hong, Yule Liu
Journal: Nature .
PubMed ID: 37704724
Doi: 10.1038/s41586-023-06533-3
Are Histidine Kinases of Arbuscular Mycorrhizal Fungi Involved in the Response to Ethylene and Cytokinins?
Authors: Ayla Mongès, Hajar Yaakoub, Baptiste Bidon, Gaëlle Glévarec, François Héricourt, Sabine Carpin, Lucie Chauderon, Lenka Drašarová, Lukáš Spíchal, Brad M Binder, Nicolas Papon, Soizic Rochange
Journal: Mol Plant Microbe Interact .
PubMed ID: 37851914
Doi: 10.1094/MPMI-05-23-0056-R
Products & Services: Gene Synthesis   
A novel pathogenic mutation of MeCP2 impairs chromatin association independent of protein levels
Authors: Jian Zhou, Claudia Cattoglio, Yingyao Shao, Harini P Tirumala, Carlo Vetralla, Sameer S Bajikar, Yan Li, Hu Chen, Qi Wang, Zhenyu Wu, Bing Tang, Mahla Zahabiyon, Aleksandar Bajic, Xiangling Meng, Jack J Ferrie, Anel LaGrone, Ping Zhang, Jean J Kim, Jianrong Tang, Zhandong Liu, Xavier Darzacq, Nathaniel Heintz, Robert Tjian, Huda Y Zoghbi
Journal: Genes Dev
PubMed ID: 37890975
Doi: 10.1101/gad.350733.123
A critical role for iron and zinc homeostatic systems in the evolutionary adaptation of to metal restriction
Authors: Joy R Paterson, Joshua M Wadsworth, Ping Hu, Gary J Sharples
Journal: Microb Genom
PubMed ID: 38054971
Doi: 10.1099/mgen.0.001153
Overexpressing CsPSY1 Gene of Tea Plant, Encoding a Phytoene Synthase, Improves α-Carotene and β-Carotene Contents in Carrot
Authors: Jing-Wen Li, Ping Zhou, Yuan-Jie Deng, Zhi-Hang Hu, Xing-Hui Li, Xuan Chen, Ai-Sheng Xiong, Jing Zhuang
Journal: Mol Biotechnol
PubMed ID: 37897587
Doi: 10.1007/s12033-023-00942-5
Preclinical efficacy of a cell division protein candidate gonococcal vaccine identified by artificial intelligence
Authors: Sunita Gulati, Andreas Holm Mattsson, Sophie Schussek, Bo Zheng, Rosane B DeOliveira, Jutamas Shaughnessy, Lisa A Lewis, Peter A Rice, Pär Comstedt, Sanjay Ram
Journal: MBio
PubMed ID: 37905891
Doi: 10.1128/mbio.02500-23
Analytical Ultracentrifugation Detects Quaternary Rearrangements and Antibody-Induced Conformational Selection of the SARS-CoV-2 Spike Trimer
Authors: Giuditta Guerrini, Dora Mehn, Francesco Fumagalli, Sabrina Gioria, Mattia Pedotti, Luca Simonelli, Filippo Bianchini, Davide F Robbiani, Luca Varani, Luigi Calzolai
Journal: Int J Mol Sci
PubMed ID: 37834322
Doi: 10.3390/ijms241914875
Products & Services: Custom DNA/RNA Oligos   
Binding mechanism and biological effects of flavone DYRK1A inhibitors for the design of new antidiabetics
Authors: Katarzyna Pustelny, Przemyslaw Grygier, Agata Barzowska, Barbara Pucelik, Alex Matsuda, Krzysztof Mrowiec, Emilia Slugocka, Grzegorz M Popowicz, Grzegorz Dubin, Anna Czarna
Journal: Sci Rep
PubMed ID: 37872245
Doi: 10.1038/s41598-023-44810-3
Products & Services: Plasmid DNA Preparation   
β-Arrestin-dependent and -independent endosomal G protein activation by the vasopressin type 2 receptor
Authors: Carole Daly, Akim Abdul Guseinov, Hyunggu Hahn, Adam Wright, Irina G Tikhonova, Alex Rojas Bie Thomsen, Bianca Plouffe
Journal: Elife
PubMed ID: 37855711
Doi: 10.7554/eLife.87754
Products & Services: PCR Cloning and Subcloning   
Whole-genome sequence and mass spectrometry study of the snow blight fungus Phacidium infestans (Karsten) DSM 5139 growing at freezing temperatures
Authors: C Zerouki, K Chakraborty, S Kuittinen, A Pappinen, O Turunen
Journal: Mol Genet Genomics
PubMed ID: 37815644
Doi: 10.1007/s00438-023-02073-7
Products & Services: Combinatorial DNA Libraries   
Opsin 5 mediates violet light-induced early growth response-1 expression in the mouse retina
Authors: Heonuk Jeong, Deokho Lee, Xiaoyan Jiang, Kazuno Negishi, Kazuo Tsubota, Toshihide Kurihara
Journal: Sci Rep
PubMed ID: 37857760
Doi: 10.1038/s41598-023-44983-x
Products & Services: Gene Synthesis   
Rapamycin nanoparticles increase the therapeutic window of engineered interleukin-2 and drive expansion of antigen-specific regulatory T cells for protection against autoimmune disease
Authors: Takashi Kei Kishimoto, Max Fournier, Alicia Michaud, Gina Rizzo, Christopher Roy, Teresa Capela, Natasha Nukolova, Ning Li, Liam Doyle, Fen-Ni Fu, Derek VanDyke, Peter G Traber, Jamie B Spangler, Sheldon S Leung, Petr O Ilyinskii
Journal: J Autoimmun
PubMed ID: 37844543
Doi: 10.1016/j.jaut.2023.103125
Nucleic acid-triggered NADase activation of a short prokaryotic Argonaute
Authors: Xiaopan Gao , Kun Shang , Kaixiang Zhu , Linyue Wang , Zhixia Mu , Xingke Fu , Xia Yu , Bo Qin , Hongtao Zhu , Wei Ding , Sheng Cui
Journal: Nature .
PubMed ID: 37783228
Doi: 10.1038/s41586-023-06665-6
Products & Services: DNA Sequencing   
Plant-Based Meat Analogues Weaken Gastrointestinal Digestive Function and Show Less Digestibility Than Real Meat in Mice
Authors: Yunting Xie , Linlin Cai , Zhiji Huang , Kai Shan , Xinglian Xu , Guanghong Zhou , Chunbao Li
Journal: J Agric Food Chem .
PubMed ID: 36070521
Doi: 10.1021/acs.jafc.2c04246
Products & Services: Gene Synthesis   
Single Amino Acid Mutation Decouples Photochemistry of the BLUF Domain from the Enzymatic Function of OaPAC and Drives the Enzyme to a Switched-on State
Authors: Jinnette Tolentino Collado, Emoke Bodis, Jonatan Pasitka, Mihaly Szucs, Zsuzsanna Fekete, Nikolett Kis-Bicskei, Elek Telek, Kinga Pozsonyi, Sofia M Kapetanaki, Greg Greetham, Peter J Tonge, Stephen R Meech, Andras Lukacs
Journal: J Mol Biol
PubMed ID: 37827329
Doi: 10.1016/j.jmb.2023.168312
Rational Design of Taxadiene Hydroxylase by Ancestral Enzyme Construction and the Elucidation of Key Amino Acids
Authors: Zihan Zhang, Longhao Huang, Zhi-Jun Zhang, Jian-He Xu, Hui-Lei Yu
Journal: Biochemistry
PubMed ID: 37902563
Doi: 10.1021/acs.biochem.3c00411
FHL1 promotes chikungunya and o'nyong-nyong virus infection and pathogenesis with implications for alphavirus vaccine design
Authors: Wern Hann Ng, Xiang Liu, Zheng L Ling, Camilla N O Santos, Lucas S Magalhães, Andrew J Kueh, Marco J Herold, Adam Taylor, Joseph R Freitas, Sandra Koit, Sainan Wang, Andrew R Lloyd, Mauro M Teixeira, Andres Merits, Roque P Almeida, Nicholas J C King, Suresh Mahalingam
Journal: Nat Commun
PubMed ID: 37884534
Doi: 10.1038/s41467-023-42330-2
Biochemical and biophysical properties of a rare TTRA81V mutation causing mild transthyretin amyloid cardiomyopathy
Authors: Qiuyan Sha, Yanli Zhang, Mengdie Wang, Jialu Sun, Yunlong Zhang, Xinxin Zhang, Ning Wang, Yu Liu, Ying Liu
Journal: ESC Heart Fail
PubMed ID: 37827496
Doi: 10.1002/ehf2.14543
ATOR-1017 (evunzekibart), an Fc-gamma receptor conditional 4-1BB agonist designed for optimal safety and efficacy, activates exhausted T cells in combination with anti-PD-1
Authors: Karin Enell Smith, Sara Fritzell, Anneli Nilsson, Karin Barchan, Anna Rosén, Lena Schultz, Laura Varas, Anna Säll, Nadia Rose, Maria Håkansson, Laura von Schantz, Peter Ellmark
Journal: Cancer Immunol Immunother
PubMed ID: 37796298
Doi: 10.1007/s00262-023-03548-7
Products & Services: Gene Synthesis   
Industry updates from the field of stem cell research and regenerative medicine in August 2023
Authors: Dusko Ilic, Mirjana Liovic
Journal: Regen Med
PubMed ID: 37786963
Doi: 10.2217/rme-2023-0181
Author Correction: A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates
Authors: Payton A-B Weidenbacher, Mrinmoy Sanyal, Natalia Friedland, Shaogeng Tang, Prabhu S Arunachalam, Mengyun Hu, Ozan S Kumru, Mary Kate Morris, Jane Fontenot, Lisa Shirreff, Jonathan Do, Ya-Chen Cheng, Gayathri Vasudevan, Mark B Feinberg, Francois J Villinger, Carl Hanson, Sangeeta B Joshi, David B Volkin, Bali Pulendran, Peter S Kim
Journal: Nat Commun
PubMed ID: 37798288
Doi: 10.1038/s41467-023-42061-4
Products & Services: Peptide Synthesis   
LRRK2 G2019S promotes astrocytic inflammation induced by oligomeric α-synuclein through NF-κB pathway
Authors: Kai-Jie He, Jin-Bao Zhang, Jun-Yi Liu, Feng-Lun Zhao, Xiao-Yu Yao, Yu-Ting Tang, Jin-Ru Zhang, Xiao-Yu Cheng, Li-Fang Hu, Fen Wang, Chun-Feng Liu
Journal: iScience
PubMed ID: 37876795
Doi: 10.1016/j.isci.2023.108130
Products & Services: Molecular Biology Reagents   
Development and characterization of a prototypic pan-amyloid clearing agent - a novel murine peptide-immunoglobulin fusion
Authors: James S Foster, Manasi Balachandran, Trevor J Hancock, Emily B Martin, Sallie Macy, Craig Wooliver, Tina Richey, Alan Stuckey, Angela D Williams, Joseph W Jackson, Stephen J Kennel, Jonathan S Wall
Journal: Front Immunol
PubMed ID: 37854603
Doi: 10.3389/fimmu.2023.1275372
Products & Services: Molecular Biology Reagents   
Dendritic Cell-Mediated Cross-Priming by a Bispecific Neutralizing Antibody Boosts Cytotoxic T Cell Responses and Protects Mice against SARS-CoV-2
Authors: Rodrigo Lázaro-Gorines, Patricia Pérez, Ignacio Heras-Murillo, Irene Adán-Barrientos, Guillermo Albericio, David Astorgano, Sara Flores, Joanna Luczkowiak, Nuria Labiod, Seandean L Harwood, Alejandro Segura-Tudela, Laura Rubio-Pérez, Yudhi Nugraha, Xiaoran Shang, Yuxing Li, Carlos Alfonso, Kaylin A Adipietro, Dinendra L Abeyawardhane, Rocío Navarro, Marta Compte, Wenbo Yu, Alexander D MacKerell, Laura Sanz, David J Weber, Francisco J Blanco, Mariano Esteban, Edwin Pozharski, Raquel Godoy-Ruiz, Inés G Muñoz, Rafael Delgado, David Sancho, Juan García-Arriaza, Luis Álvarez-Vallina
Journal: Adv Sci (Weinh)
PubMed ID: 37863812
Doi: 10.1002/advs.202304818
Selection, activity, and nuclease stabilization of cross-neutralizing DNA aptamers targeting HSV-1 and HSV-2
Authors: Michael D Schump, David I Bernstein, Fernando J Bravo, Charles P Neff
Journal: Virology
PubMed ID: 37925791
Doi: 10.1016/j.virol.2023.109916
Products & Services: Molecular Biology Reagents   
Aptabinding of tumor necrosis factor-α (TNFα) inhibits its proinflammatory effects and alleviates islet inflammation
Authors: Roaa Mahmoud, Jagan Kalivarathan, Abdul J Castillo, Sasha Wang, Brian Fuglestad, Mazhar A Kanak, Soma Dhakal
Journal: Biotechnol J
PubMed ID: 37772688
Doi: 10.1002/biot.202300374
Products & Services: Molecular Biology Reagents   
GhL1L1 regulates the contents of unsaturated fatty acids by activating the expression of GhFAD2 genes in cotton
Authors: Dandan Yue, Xuyang Hao, Bei Han, Jiao Xu, Weinan Sun, Xiaoping Guo, Xianlong Zhang, Xiyan Yang
Journal: Gene
PubMed ID: 37839764
Doi: 10.1016/j.gene.2023.147899
Products & Services: PCR Cloning and Subcloning   
A newly identified ferritin L-subunit variant results in increased proteasomal subunit degradation, impaired complex assembly, and severe hypoferritinemia
Authors: Dayana Shagidov, Noga Guttmann-Raviv, Séverine Cunat, Liora Frech, Muriel Giansily-Blaizot, Niraj Ghatpande, Gili Abelya, Gabriel A Frank, Patricia Aguilar Martinez, Esther G Meyron-Holtz
Journal: Am J Hematol
PubMed ID: 37867341
Doi: 10.1002/ajh.27124
Characterization of a thermostable Cas12a ortholog
Authors: Jing Wu, Pan Gao, Yajing Shi, Caixiang Zhang, Xiaohan Tong, Huidi Fan, Xi Zhou, Ying Zhang, Hao Yin
Journal: Cell Insight
PubMed ID: 38047138
Doi: 10.1016/j.cellin.2023.100126
Products & Services: Molecular Biology Reagents   
A circRNA therapy based on Rnf103 to inhibit Vibrio anguillarum infection
Authors: Weiwei Zheng, Xing Lv, Yaqi Tao, Yanqiu Cui, Xiangxiang Zhu, Tongtong Zhu, Tianjun Xu
Journal: Cell Rep
PubMed ID: 37874674
Doi: 10.1016/j.celrep.2023.113314
Products & Services: DNA Sequencing   
Genistein alleviates chronic heat stress-induced lipid metabolism disorder and mitochondrial energetic dysfunction by activating the GPR30-AMPK-PGC-1α signaling pathways in the livers of broiler chickens
Authors: Longlong Li, Ze Lu, Yulei Wang, Ying Yang, Huihui Wang, Haitian Ma
Journal: Poult Sci
PubMed ID: 37984004
Doi: 10.1016/j.psj.2023.103251
Condensation of the N-terminal domain of human topoisomerase 1 is driven by electrostatic interactions and tuned by its charge distribution
Authors: Greta Bianchi, Marco Mangiagalli, Diletta Ami, Junaid Ahmed, Silvia Lombardi, Sonia Longhi, Antonino Natalello, Peter Tompa, Stefania Brocca
Journal: Int J Biol Macromol
PubMed ID: 38287572
Doi: 10.1016/j.ijbiomac.2023.127754
Unfolding of an RNA G-quadruplex motif in the negative strand genome of porcine reproductive and respiratory syndrome virus by host and viral helicases to promote viral replication
Authors: Puxian Fang, Congbao Xie, Ting Pan, Ting Cheng, Wei Chen, Sijin Xia, Tong Ding, Junkang Fang, Yanrong Zhou, Liurong Fang, Dengguo Wei, Shaobo Xiao
Journal: Nucleic Acids Res
PubMed ID: 37739415
Doi: 10.1093/nar/gkad759
Histone Abundance Quantification via Flow Cytometry of Htb2-GFP Allows Easy Monitoring of Cell Cycle Perturbations in Living Yeast Cells, Comparable to Standard DNA Staining
Authors: Maria V Kulakova, Eslam S M O Ghazy, Fedor Ryabov, Yaroslav M Stanishevskiy, Michael O Agaphonov, Alexander I Alexandrov
Journal: J Fungi (Basel)
PubMed ID: 37888289
Doi: 10.3390/jof9101033
A spacer design strategy for CRISPR-Cas12f1 with single-nucleotide polymorphism mutation resolution capability and its application in the mutations diagnosis of pathogens
Authors: Panqi Gao, Maoyi Yang, Yi Chen, Jun Yan, Miaomiao Han, Haijun Deng, Keli Qian, Jiandong Yang, Yaoqin Lu, Ling Zhou, Ailong Huang, Xiaosong Li, Wanyan Deng, Quanxin Long
Journal: J Med Virol
PubMed ID: 37855689
Doi: 10.1002/jmv.29189
STT3A-mediated viral N-glycosylation underlies the tumor selectivity of oncolytic virus M1
Authors: Deli Song, Xudong Jia, Yuanzhu Gao, Tong Xiao, Jia Dan, Runling Shen, Jing Cai, Jiankai Liang, Wenbo Zhu, Jun Hu, Guangmei Yan, Qinfen Zhang, Yuan Lin
Journal: Oncogene
PubMed ID: 37864032
Doi: 10.1038/s41388-023-02872-7
Products & Services: Molecular Biology Reagents   
Improved prime editing allows for routine predictable gene editing in Physcomitrium patens
Authors: Pierre-François Perroud, Anouchka Guyon-Debast, Josep M Casacuberta, Wyatt Paul, Jean-Philippe Pichon, David Comeau, Fabien Nogué
Journal: J Exp Bot
PubMed ID: 37243510
Doi: 10.1093/jxb/erad189
Products & Services: Molecular Biology Reagents   
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