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Targeting the heparan sulfate-binding site of RAGE with monoclonal antibodies

Authors: Chihyean Ong, Miaomiao Li, Ding Xu

Journal: Glycobiology

PubMed ID: 38181393

Doi: 10.1093/glycob/cwae001

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A measles-vectored vaccine candidate expressing prefusion-stabilized SARS-CoV-2 spike protein brought to phase I/II clinical trials: protection of African green monkeys from COVID-19 disease

Authors: Sham Nambulli, Nicolas Escriou, Linda J Rennick, Matthew J Demers, Natasha L Tilston-Lunel, Anita K McElroy, Dominique J Barbeau, Nicholas A Crossland, Ryan M Hoehl, Sabrina Schrauf, Alexander G White, H Jacob Borish, Jaime A Tomko, Lonnie J Frye, Charles A Scanga, JoAnne L Flynn, Annette Martin, Christiane Gerke, Amy L Hartman, W Paul Duprex

Journal: J Virol

PubMed ID: 38563762

Doi: 10.1128/jvi.01762-23

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Reverse-Phase Protein Microarrays for Overexpressed Lysates Reveal a Novel Tyrosine Kinase

Authors: Batuhan Birol Keskin, Chien-Sheng Chen, Pei-Shan Tsai, Pin-Xian Du, John Harvey M Santos, Guan-Da Syu

Journal: Anal Chem

PubMed ID: 38683735

Doi: 10.1021/acs.analchem.4c00965

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Distinguishing individual photobodies using Oligopaints reveals thermo-sensitive and -insensitive phytochrome B condensation at distinct subnuclear locations

Authors: Juan Du, Keunhwa Kim, Meng Chen

Journal: Nat Commun

PubMed ID: 38684657

Doi: 10.1038/s41467-024-47789-1

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Functional and structural insights into activation of TRPV2 by weak acids

Authors: Ferdinand M Haug, Ruth A Pumroy, Akshay Sridhar, Sebastian Pantke, Florian Dimek, Tabea C Fricke, Axel Hage, Christine Herzog, Frank G Echtermeyer, Jeanne de la Roche, Adrian Koh, Abhay Kotecha, Rebecca J Howard, Erik Lindahl, Vera Moiseenkova-Bell, Andreas Leffler

Journal: EMBO J

PubMed ID: 38671253

Doi: 10.1038/s44318-024-00106-4

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A novel engineered IL-21 receptor arms T-cell receptor-engineered T cells (TCR-T cells) against hepatocellular carcinoma

Authors: Wei Zhu, Zhiming Zhang, Jinzhang Chen, Xiaolan Chen, Lei Huang, Xiaoyong Zhang, Xuan Huang, Na Ma, Weikang Xu, Xuan Yi, Xinyu Lu, Xin Fu, Siwei Li, Guoheng Mo, Yiyue Wang, Guosheng Yuan, Mengya Zang, Qi Li, Xiaotao Jiang, Yajing He, Sha Wu, Yukai He, Yongyin Li, Jinlin Hou

Journal: Signal Transduct Target Ther

PubMed ID: 38643203

Doi: 10.1038/s41392-024-01792-6

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Dual mode of DDX3X as an ATP-dependent RNA helicase and ATP-independent nucleic acid chaperone

Authors: Yi-Ning He, Xiao-Rui Han, Dong Wang, Jia-Li Hou, Xi-Miao Hou

Journal: Biochem Biophys Res Commun

PubMed ID: 38669753

Doi: 10.1016/j.bbrc.2024.149964

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Ferroptosis and HMGB2 induced calreticulin translocation required for immunogenic cell death are controlled by the nuclear exporter XPO1

Authors: Ian Blair, Jingqi Fan, Kevin Gillespie, Clementina Mesaros

Journal: Res Sq

PubMed ID: 38496553

Doi: 10.21203/rs.3.rs-4009459/v1

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Developing Plant Exosomes as an Advanced Delivery System for Cosmetic Peptide

Authors: Jiali Hou, Wei Wei, Zaijun Geng, Zhenxing Zhang, Hui Yang, Xuhui Zhang, Li Li, Qi Gao

Journal: ACS Appl Bio Mater

PubMed ID: 38598772

Doi: 10.1021/acsabm.4c00096

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in Ticks Blood-Feeding on Migratory Birds in Sweden

Authors: Peter Wilhelmsson, Malin Lager, Thomas G T Jaenson, Jonas Waldenström, Björn Olsen, Per-Eric Lindgren

Journal: Microorganisms

PubMed ID: 38674679

Doi: 10.3390/microorganisms12040735

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Coiled-Coil Protein Hydrogels Engineered with Minimized Fiber Diameters for Sustained Release of Doxorubicin in Triple-Negative Breast Cancer

Authors: Dustin Britton, Jakub Legocki, Deven Paul, Olga Katsara, Orlando Aristizabal, Neelam Pandya, Orin Mishkit, Yingxin Xiao, Matias Aristizabal, Neha Rahman, Robert Schneider, Youssef Z Wadghiri, Jin Kim Montclare

Journal: ACS Biomater Sci Eng

PubMed ID: 38622760

Doi: 10.1021/acsbiomaterials.4c00349

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Protein localization of aquaporins in the adult female disease vector mosquito,

Authors: Britney Picinic, Jean-Paul V Paluzzi, Andrew Donini

Journal: Front Insect Sci

PubMed ID: 38699443

Doi: 10.3389/finsc.2024.1365651

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Validation for the function of protein C in mouse models

Authors: Ya Liu, Maoping Cai, Yan Chen, Guocai Wu, Songyu Li, Zhanghui Chen

Journal: PeerJ

PubMed ID: 38680896

Doi: 10.7717/peerj.17261

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Co-clustering of EphB6 and ephrinB1 in trans restrains cancer cell invasion

Authors: Lung-Yu Liang, Niall D Geoghegan, Michael Mlodzianoski, Andrew Leis, Lachlan W Whitehead, Minglyanna G Surudoi, Samuel N Young, Peter Janes, Doulin Shepherd, Debnath Ghosal, Kelly L Rogers, James M Murphy, Isabelle S Lucet

Journal: Commun Biol

PubMed ID: 38627519

Doi: 10.1038/s42003-024-06118-4

Products & Services: DNA Sequencing

Gene replacement therapy in Bietti crystalline corneoretinal dystrophy: an open-label, single-arm, exploratory trial

Authors: Jinyuan Wang, Jinlu Zhang, Shicheng Yu, Hongyan Li, Shaohong Chen, Jingting Luo, Haibo Wang, Yuxia Guan, Haihan Zhang, Shiyi Yin, Huili Wang, Heping Li, Junle Liu, Jingyuan Zhu, Qiong Yang, Ying Sha, Chuan Zhang, Yuhang Yang, Xuan Yang, Xifang Zhang, Xiuli Zhao, Likun Wang, Liping Yang, Wenbin Wei

Journal: Signal Transduct Target Ther

PubMed ID: 38653979

Doi: 10.1038/s41392-024-01806-3

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Identification of a homoarginine biosynthetic gene from a microcystin biosynthetic pathway in Fischerella sp PCC 9339

Authors: Xiaodan Ouyang, Matti Wahlsten, Maija Pollari, Endrews Delbaje, Jouni Jokela, David P Fewer

Journal: Toxicon

PubMed ID: 38670499

Doi: 10.1016/j.toxicon.2024.107733

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A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development

Authors: Zhijuan Hu 1, Liang Yang 2, Maolei Zhang 2, Haite Tang 2, Yile Huang 3, Yujie Su 4, Yingzhe Ding 3, Chong Li 2, Mengfei Wang 4, Yunhao Zhou 4, Qing Zhang 5, Liman Guo 5, Yue Wu 5, Qianqian Wang 6, Ning Liu 6, Haoran Kang 2, Yi Wu 2, Deyang Yao 2, Yukun Li 4, Zifeng Ruan 4, Hao Wang 2, Feixiang Bao 2, Guopan Liu 3, Junwei Wang 2, Yaofeng Wang 3, Wuming Wang 7, Gang Lu 7, Dajiang Qin 8, Duanqing Pei 9, Wai-Yee Chan 7, Xingguo Liu

Journal: Cell Metab

PubMed ID: 38703762

Doi: 10.1016/j.cmet.2024.04.012

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Cryo-EM structure of the human Asc-1 transporter complex

Authors: Yaning Li , Yingying Guo, Angelika Bröer, Lu Dai, Stefan Brӧer , Renhong Yan

Journal: Nat Commun

PubMed ID: 38589439

Doi: 10.1038/s41467-024-47468-1

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Depolymerization of SUMO chains induces slender to stumpy differentiation in T brucei bloodstream parasites

Authors: Paula Ana Iribarren, Lucía Ayelén Di Marzio, María Agustina Berazategui, Andreu Saura, Lorena Coria, Juliana Cassataro, Federico Rojas, Miguel Navarro, Vanina Eder Alvarez

Journal: PLoS Pathog

PubMed ID: 38635823

Doi: 10.1371/journal.ppat.1012166

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Stepwise activation of a metabotropic glutamate receptor

Authors: Kaavya Krishna Kumar, Haoqing Wang, Chris Habrian, Naomi R Latorraca, Jun Xu, Evan S O'Brien, Chensong Zhang, Elizabeth Montabana, Antoine Koehl, Susan Marqusee, Ehud Y Isacoff, Brian K Kobilka

Journal: Nature

PubMed ID: 38632403

Doi: 10.1038/s41586-024-07327-x

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FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy

Authors: Jack D Chan, Christina M Scheffler, Isabelle Munoz, Kevin Sek, Joel N Lee, Yu-Kuan Huang, Kah Min Yap, Nicole Y L Saw, Jasmine Li, Amanda X Y Chen, Cheok Weng Chan, Emily B Derrick, Kirsten L Todd, Junming Tong, Phoebe A Dunbar, Jiawen Li, Thang X Hoang, Maria N de Menezes, Emma V Petley, Joelle S Kim, Dat Nguyen, Patrick S K Leung, Joan So, Christian Deguit, Joe Zhu, Imran G House, Lev M Kats, Andrew M Scott, Benjamin J Solomon, Simon J Harrison, Jane Oliaro, Ian A Parish, Kylie M Quinn, Paul J Neeson, Clare Y Slaney, Junyun Lai, Paul A Beavis, Phillip K Darcy

Journal: Nature

PubMed ID: 38600376

Doi: 10.1038/s41586-024-07242-1

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Transmembrane conformation of the envelope protein of an alpha coronavirus, NL63

Authors: Iva Sučec, Yanina Pankratova, Mriganka Parasar, Mei Hong

Journal: Protein Sci

PubMed ID: 38501465

Doi: 10.1002/pro.4923

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Kalium channelrhodopsins effectively inhibit neurons

Authors: Stanislav Ott, Sangyu Xu, Nicole Lee, Ivan Hong, Jonathan Anns, Danesha Devini Suresh, Zhiyi Zhang, Xianyuan Zhang, Raihanah Harion, Weiying Ye, Vaishnavi Chandramouli, Suresh Jesuthasan, Yasunori Saheki, Adam Claridge-Chang

Journal: Nat Commun

PubMed ID: 38658537

Doi: 10.1038/s41467-024-47203-w

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RATA: A novel class A carbapenemase with broad geographic distribution and potential for global spread

Authors: Hongyan Luo, Zhishuang Yang, Ting Lei, Caixia Li, Zuoyong Zhou, Mingshu Wang, Dekang Zhu, Pei Li, Anchun Cheng

Journal: Sci Total Environ

PubMed ID: 38692330

Doi: 10.1016/j.scitotenv.2024.172873

Products & Services: Molecular Biology Reagents

The SARS-CoV-2 Spike Protein Receptor-Binding Domain Expressed in Rice Callus Features a Homogeneous Mix of Complex-Type Glycans

Authors: Guillermo Sobrino-Mengual, Victoria Armario-Nájera, Juliette Balieu, Marie-Laure Walet-Balieu, Andrea Saba-Mayoral, Ana M Pelacho, Teresa Capell, Paul Christou, Muriel Bardor, Patrice Lerouge

Journal: Int J Mol Sci

PubMed ID: 38674051

Doi: 10.3390/ijms25084466

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Mutation of the peptide-regulated transcription factor ComR for amidated peptide specificity and heterologous function in WCFS1

Authors: Michael Brasino, Eli Wagnell, E Sila Ozdemir, Srivathsan Ranganathan, Justin Merritt

Journal: Microbiol Spectr

PubMed ID: 38687019

Doi: 10.1128/spectrum.00517-24

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Identification and Quantification of a Pneumococcal Cell Wall Polysaccharide by Antibody-Enhanced Chromatography Assay

Authors: James Z Deng, Zhifeng Chen, James Small, Yue Yuan, Kara Cox, Aimin Tang, Jeanette Roman, Liming Guan, Katrina Feller, Frances Ansbro, Kalpit Vora

Journal: Vaccines (Basel)

PubMed ID: 38793720

Doi: 10.3390/vaccines12050469

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Selective Detection of Active Extracellular Granzyme A by Using a Novel Fluorescent Immunoprobe with Application to Inflammatory Diseases

Authors: Ana Senan-Salinas, Laura Comas, Patricia Esteban, Marcela Garzón-Tituaña, Zhiming Cheng, Llipsy Santiago, Maria Pilar Domingo, Ariel Ramírez-Labrada, José Ramón Paño-Pardo, Marc Vendrell, Julián Pardo, Maykel A Arias, Eva M Galvez

Journal: ACS Pharmacol Transl Sci

PubMed ID: 38751645

Doi: 10.1021/acsptsci.4c00065

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Antibacterial and Hemolytic Activity of Antimicrobial Hydrogels Utilizing Immobilized Antimicrobial Peptides

Authors: Edvin Blomstrand, Elin Posch, Annija Stepulane, Anand K Rajasekharan, Martin Andersson

Journal: Int J Mol Sci

PubMed ID: 38673786

Doi: 10.3390/ijms25084200

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Artemisinin Confers Cytoprotection toward Hydrogen Peroxide-Induced Cell Apoptosis in Retinal Pigment Epithelial Cells in Correlation with the Increased Acetylation of Histone H4 at Lysine 8

Authors: Chao Yang, Lijun Ge, Xiyong Yu, Philip Lazarovici, Wenhua Zheng

Journal: Molecules

PubMed ID: 38675608

Doi: 10.3390/molecules29081789

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Biophysical characterization and insights into the oligomeric nature of CD2-associated protein

Authors: Abrar H Qadri, Jyotsana Prajapati, Iqball Faheem, Utsa Bhattacharjee, Hari Krishnan Padmanaban, Sandeep Kn Mulukala, Anil K Pasupulati

Journal: Int J Biochem Mol Biol

PubMed ID: 38765876

Doi: 10.62347/UVSH8436

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Injectable self-assembled GDF5-containing dipeptide hydrogels for enhanced tendon repair

Authors: Ming Zhang, Hao Wang, Guan-Chun Dai, Pan-Pan Lu, Yu-Cheng Gao, Mu-Ming Cao, Ying-Juan Li, Yun-Feng Rui

Journal: Mater Today Bio

PubMed ID: 38600922

Doi: 10.1016/j.mtbio.2024.101046

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Higher correlation between neutralizing antibodies and surrogate neutralizing or binding antibodies in COVID-19 patients than vaccine recipients

Authors: Hatairat Lerdsamran, Ratikorn Anusorntanawat, Kantima Sangsiriwut, Suteema Sawadpongpan, Jarunee Prasertsopon, Nattakarn Thinpan, Poj Intalapaporn, Ranida Techasuwanna, Pilailuk Okada, Pilaipan Puthavathana

Journal: PLoS ONE

PubMed ID: 38626137

Doi: 10.1371/journal.pone.0298033

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Characterization of 35 novel NR5A1/SF-1 variants identified in individuals with atypical sexual development: The SF1next study

Authors: Rawda Naamneh Elzenaty, Idoia Martinez de Lapiscina, Chrysanthi Kouri, Kay-Sara Sauter, Grit Sommer, Luis Castaño, Christa E Flück

Journal: J Clin Endocrinol Metab

PubMed ID: 38623954

Doi: 10.1210/clinem/dgae251

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Development of a latex agglutination test based on VH antibody fragment for detection of Streptococcus suis serotype 2

Authors: Kiratika Chidkoksung, Nattihda Parakasikron, Suphachai Nuanualsuwan, Kannika Khantasup

Journal: PLoS ONE

PubMed ID: 38568909

Doi: 10.1371/journal.pone.0299691

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Intestinal MAdCAM-1 imaging as biomarker for prognostic in murine models of multiple sclerosis

Authors: Erwan Baudron, Sara Martinez de Lizarrondo, Maxime Gauberti, Barbara Delaunay-Piednoir, Antoine P Fournier, Denis Vivien, Fabian Docagne, Isabelle Bardou

Journal: Brain Behav Immun

PubMed ID: 38604270

Doi: 10.1016/j.bbi.2024.04.006

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An improved system to generate recombinant canine distemper virus

Authors: Huai Cheng, Hewei Zhang, Huayun Zhang, Huanchang Cai, Min Liu, Mingen Yu, Meihua Xiang, Shubo Wen, Jingqiang Ren

Journal: BMC Vet Res

PubMed ID: 38678249

Doi: 10.1186/s12917-023-03830-x

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Catalytic specificity and crystal structure of cystathionine γ-lyase from Pseudomonas aeruginosa

Authors: Marco Pedretti, Carmen Fernández-Rodríguez, Carolina Conter, Iker Oyenarte, Filippo Favretto, Adele di Matteo, Paola Dominici, Maria Petrosino, Maria Luz Martinez-Chantar, Tomas Majtan, Alessandra Astegno, Luis Alfonso Martínez-Cruz

Journal: Sci Rep

PubMed ID: 38654065

Doi: 10.1038/s41598-024-57625-7

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A cAMP-biosensor-based assay for measuring plasma arginine-vasopressin levels

Authors: Kosuke Doi, Kouki Kawakami, Tatsuya Ikuta, Asuka Inoue

Journal: Sci Rep

PubMed ID: 38658606

Doi: 10.1038/s41598-024-60035-4

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Identification and structural characterization of small molecule inhibitors of PINK1

Authors: Shafqat Rasool, Tara Shomali, Luc Truong, Nathalie Croteau, Simon Veyron, Bernardo A Bustillos, Wolfdieter Springer, Fabienne C Fiesel, Jean-François Trempe

Journal: Sci Rep

PubMed ID: 38565869

Doi: 10.1038/s41598-024-58285-3

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Correlates of protection against symptomatic SARS-CoV-2 in vaccinated children

Authors: Youjia Zhong, Alicia Y H Kang, Carina J X Tay, Hui' En Li, Nurul Elyana, Chee Wah Tan, Wee Chee Yap, Joey M E Lim, Nina Le Bert, Kuan Rong Chan, Eugenia Z Ong, Jenny G Low, Lynette P Shek, Elizabeth Huiwen Tham, Eng Eong Ooi

Journal: Nat Med

PubMed ID: 38689059

Doi: 10.1038/s41591-024-02962-3

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Coordination of actin plus-end dynamics by IQGAP1, formin, and capping protein

Authors: Morgan L Pimm, Brian K Haarer, Alexander D Nobles, Laura M Haney, Alexandra G Marcin, Jessica L Henty-Ridilla

Journal: biorxiv

PubMed ID: 37205555

Doi: 10.1101/2023.05.04.539490

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Evolutionarily conserved ovarian fluid proteins are responsible for extending egg viability in salmonid fish

Authors: Aurélie Gueho, Daniel Żarski, Hélène Rime, Blandine Guével, Emmanuelle Com, Régis Lavigne, Thaovi Nguyen, Jérôme Montfort, Charles Pineau, Julien Bobe

Journal: Sci Rep

PubMed ID: 38671194

Doi: 10.1038/s41598-024-60118-2

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Decoding the blueprint of receptor binding by filoviruses through large-scale binding assays and machine learning

Authors: Gorka Lasso; Michael Grodus; Estefania Valencia; Veronica DeJesus; Eliza Liang; Isabel Delwel; Rob H. Bortz; Dmitry Lupyan; Hanna Y. Ehrlich; Adrian A. Castellanos; Andrea Gazzo; Heather L. Wells; Supaporn Wacharapluesadee; Alexandre Tremeau-Bravard; Janine F.R. Seetahal; Tom Hughes; Jimmy Lee; Mei-Ho Lee; Anna R. Sjodin; Marike Geldenhuys; Marinda Mortlock; Isamara Navarrete-Macias; Kirsten Gilardi; Michael R. Willig; Alessandra F.D. Nava; Elisabeth H. Loh; Makda Asrat; Tierra Smiley-Evans; Walter S. Magesa; Sijali Zikankuba; David Wolking; Gerardo Suz n; Rafael Ojeda-Flores; Christine V.F. Carrington; Ariful Islam; Jonathan H. Epstein; Wanda Markotter; Christine K. Johnson; Tracey Goldstein; Barbara A. Han; Jonna A.K. Mazet; Rohit K. Jangra; Kartik Chandran; Simon J. Anthony

Journal: Cell Host & Microbe

PubMed ID: 39818205

Doi: 10.1016/j.chom.2024.12.016

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Deciphering the unique autoregulatory mechanisms and substrate specificity of the understudied DCLK3 kinase linked to neurodegenerative diseases

Authors: Jason D. Lu; Peng Zhao; Anup Prasad; Neha Gupta; Nathan Gravel; Tej Shidhaye; Lance Wells; Samiksha Katiyar; Natarajan Kannan

Journal: The Journal of Biological Chemistry

PubMed ID: 40902973

Doi: 10.1016/j.jbc.2025.110664

Virtual screening and evaluation of bioactive peptides from Haliotis discus hannai as potential HMGCR inhibitors for hyperlipidemia treatment

Authors: Kun Qiao; Lina Liu; Yihui Chen; Qiongmei Huang; Bei Chen; Jingna Wu; Wenmei Huang; Zhiyu Liu

Journal: Frontiers in nutrition

PubMed ID: 39811675

Doi: 10.3389/fnut.2024.1525768

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Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation

Authors: Miko aj S abicki; Jiho Park; Rados aw P. Nowak; Shourya S. Roy Burman; Jesse Pellman; Charles Zou; Hlib Razumkov; Jeannie Carreiro; Simran Rastogi; Anna Goldstein; Marek M. Nagiec; Katherine A. Donovan; Jianwei Che; Moritz Hunkeler; Qixiang Geng; Chi-Lin Hsu; Megha Lakshminarayan; Chelsea Shu; Rebecca L. Zon; Zuzanna Kozicka; Paul M.C. Park; Jonathan M. Tsai; Hojong Yoon; Lyn H. Jones; Adam S. Sperling; Nathanael S. Gray; Eric S. Fischer; Benjamin L. Ebert

Journal: Molecular Cell

PubMed ID: 40845806

Doi: 10.1016/j.molcel.2025.07.019

Expanding the druggable zinc-finger proteome defines properties of drug-induced degradation

Journal: Molecular Cell

PubMed ID: 40845806

Doi: 10.1016/j.molcel.2025.07.019

Deciphering the unique autoregulatory mechanisms and substrate specificity of the understudied DCLK3 kinase linked to neurodegenerative diseases

Authors: Jason D. Lu; Peng Zhao; Anup Prasad; Neha Gupta; Nathan Gravel; Tej Shidhaye; Lance Wells; Samiksha Katiyar; Natarajan Kannan

Journal: The Journal of Biological Chemistry

PubMed ID: 40902973

Doi: 10.1016/j.jbc.2025.110664

The Role of Fatty Acid Synthase in the Vascular Smooth Muscle Cell to Foam Cell Transition

Authors: Bethany J Bogan, Holly C Williams, Claire M Holden, Vraj Patel, Giji Joseph, Christopher Fierro, Hugo Sepulveda, W Robert Taylor, Amir Rezvan, Alejandra San Martin

Journal: Cells

PubMed ID: 38667273

Doi: 10.3390/cells13080658

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