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Tandem repeats of highly bioluminescent NanoLuc are refolded noncanonically by the Hsp70 machinery

Authors: Dimitra Apostolidou, Pan Zhang, Devanshi Pandya, Kaden Bock, Qinglian Liu, Weitao Yang, Piotr E Marszalek

Journal: Protein Sci

PubMed ID: 38284490

Doi: 10.1002/pro.4895

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The exposure to glyphosate on the integrity of intestinal epithelial tight junctions of chicks

Authors: Mohamed A Fathi, Dan Shen, Lu Luo, Yansen Li, Shaaban S Elnesr, Chunmei Li

Journal: J Environ Sci Health B

PubMed ID: 38400726

Doi: 10.1080/03601234.2024.2319006

Products & Services: Gene Synthesis

A Modified Tridecapeptide Probe for Imaging Cell Junction

Authors: Jingrui Li, Yuhan Wu, Chunyu Liu, Shu Zhang, Xin Su, Songbo Xie, Fengtang Yang

Journal: Molecules

PubMed ID: 38474514

Doi: 10.3390/molecules29051003

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Effects of polyphenol and gelatin types on the physicochemical properties and emulsion stabilization of polyphenol-crosslinked gelatin conjugates

Authors: Wenjuan Wu, Cuiping Shi, Ye Zi, Huan Gong, Lijia Chen, Guangyi Kan, Xichang Wang, Jian Zhong

Journal: Food Chem X

PubMed ID: 38440057

Doi: 10.1016/j.fochx.2024.101250

Products & Services: Protein Electrophoresis and Western

Gene-edited triple mutant Medicago plants do not flower

Authors: Axel Poulet, Min Zhao, Yongyan Peng, FangFei Tham, Mauren Jaudal, Lulu Zhang, Josien C van Wolfswinkel, Joanna Putterill

Journal: Front Plant Sci

PubMed ID: 38469328

Doi: 10.3389/fpls.2024.1357924

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Role of aminopeptidase N-like in the acquisition of begomoviruses by Bemisia tabaci, the whitefly vector

Authors: Yun-Yun Fan, Yao Chi, Na Chen, Wilmer J Cuellar, Xiao-Wei Wang

Journal: Insect Sci

PubMed ID: 38369384

Doi: 10.1111/1744-7917.13336

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PeptiVAX: A new adaptable peptides-delivery platform for development of CTL-based, SARS-CoV-2 vaccines

Authors: Sara Feola, Jacopo Chiaro, Manlio Fusciello, Salvatore Russo, Iivari Kleino, Leena Ylösmäki, Eliisa Kekäläinen, Johanna Hästbacka, Pirkka T Pekkarinen, Erkko Ylösmäki, Stefania Capone, Antonella Folgori, Angelo Raggioli, Carolina Boni, Camilla Tiezzi, Andrea Vecchi, Monica Gelzo, Hassen Kared, Alessandra Nardin, Michael Fehlings, Veronique Barban, Petra Ahokas, Tapani Viitala, Giuseppe Castaldo, Lucio Pastore, Paul Porter, Sari Pesonen, Vincenzo Cerullo

Journal: Int J Biol Macromol

PubMed ID: 38331062

Doi: 10.1016/j.ijbiomac.2024.129926

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In vitro evolution of diagnostic antibodies targeting native antigens in plasma by sandwich flow cytometry

Authors: Mingxia Liang, Fanlei Ran, Li Li, Haiying Hang, Lili An

Journal: Biotechnol J

PubMed ID: 38403438

Doi: 10.1002/biot.202300492

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Photoactivatable CRISPR/Cas12a Sensors for Biomarkers Imaging and Point-of-Care Diagnostics

Authors: Qing-Nan Li, Dong-Xia Wang, Dan-Ye Chen, Jia-Ao Lyu, Ya-Xin Wang, Shun-Li Wu, Hong-Xin Jiang, De-Ming Kong

Journal: Anal Chem

PubMed ID: 38305871

Doi: 10.1021/acs.analchem.3c05497

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Chagasin from Trypanosoma cruzi as a molecular scaffold to express epitopes of TSA-1 as soluble recombinant chimeras

Authors: Rosa Elena Cárdenas-Guerra, Octavio Montes-Flores, Edgar Ezequiel Nava-Pintor, Gerardo Reséndiz-Cardiel, Claudia Ivonne Flores-Pucheta, Yasmín Irene Rodríguez-Gavaldón, Rossana Arroyo, Maria Elena Bottazzi, Peter J Hotez, Jaime Ortega-López

Journal: Protein Expr Purif

PubMed ID: 38423156

Doi: 10.1016/j.pep.2024.106458

Products & Services: Codon Optimization

Systematic Engineering of for Efficient Production of Cytidine 5'-Monophosphate

Authors: Min Zhou, Liyuan Wei, Chongzhi Wu, Wei Chen, Zhengju Tang

Journal: ACS Omega

PubMed ID: 38371780

Doi: 10.1021/acsomega.3c07713

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Lianhua Qingke Preserves Mucociliary Clearance in Rat with Acute Exacerbation of Chronic Obstructive Pulmonary Disease by Maintaining Ciliated Cells Proportion and Protecting Structural Integrity and Beat Function of Cilia

Authors: Xiaoqi Wang, Yuanjie Hao, Yujie Yin, Yunlong Hou, Ningxin Han, Yi Liu, Zhen Li, Yaru Wei, Kun Ma, Jiaojiao Gu, Yan Ma, Hui Qi, Zhenhua Jia

Journal: Int J Chron Obstruct Pulmon Dis

PubMed ID: 38343495

Doi: 10.2147/COPD.S436323

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A SARS-CoV-2 RBD vaccine fused to the chemokine MIP-3α elicits sustained murine antibody responses over 12 months and enhanced lung T-cell responses

Authors: James Tristan Gordy, Yinan Hui, Courtney Schill, Tianyin Wang, Fengyixin Chen, Kaitlyn Fessler, Jacob Meza, Yangchen Li, Alannah D Taylor, Rowan E Bates, Petros C Karakousis, Andrew Pekosz, Jaiprasath Sachithanandham, Maggie Li, Styliani Karanika, Richard B Markham

Journal: Front Immunol

PubMed ID: 38370404

Doi: 10.3389/fimmu.2024.1292059

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Supramolecular Synthons in Protein-Ligand Frameworks

Authors: Ronan J Flood, Niamh M Mockler, Aurélien Thureau, Maura Malinska, Peter B Crowley

Journal: Cryst Growth Des

PubMed ID: 38463617

Doi: 10.1021/acs.cgd.3c01480

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Structure of the WYL-domain containing transcription activator, DriD, in complex with ssDNA effector and DNA target site

Authors: Maria A Schumacher, Emily Cannistraci, Raul Salinas, Devin Lloyd, Ella Messner, Kevin Gozzi

Journal: Nucleic Acids Res

PubMed ID: 38142455

Doi: 10.1093/nar/gkad1198

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A Composite Biomarker Signature of Type 1 Diabetes Risk Identified via Augmentation of Parallel Multi-Omics Data from a Small Cohort

Authors: Oscar Alcazar, Sung-Ting Chuang, Gang Ren, Mitsunori Ogihara, Bobbie-Jo M Webb-Robertson, Ernesto S Nakayasu, Peter Buchwald, Midhat H Abdulreda

Journal: biorxiv

PubMed ID: 38405796

Doi: 10.1101/2024.02.09.579673

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A mutational atlas for Parkin proteostasis

Authors: Lene Clausen, Vasileios Voutsinos, Matteo Cagiada, Kristoffer E Johansson, Martin Grønbæk-Thygesen, Snehal Nariya, Rachel L Powell, Magnus K N Have, Vibe H Oestergaard, Amelie Stein, Douglas M Fowler, Kresten Lindorff-Larsen, Rasmus Hartmann-Petersen

Journal: Nat Commun

PubMed ID: 38378758

Doi: 10.1038/s41467-024-45829-4

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Constitutive activation mechanism of a class C GPCR

Authors: Jinwoo Shin, Junhyeon Park, Jieun Jeong, Jordy Homing Lam, Xingyu Qiu, Di Wu, Kuglae Kim, Joo-Youn Lee, Carol V Robinson, Jaekyung Hyun, Vsevolod Katritch, Kwang Pyo Kim, Yunje Cho

Journal: Nat Struct Mol Biol

PubMed ID: 38332368

Doi: 10.1038/s41594-024-01224-7

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Metabolic engineering of Synechocystis sp PCC 6803 for the improved production of phenylpropanoids

Authors: Kateryna Kukil, Pia Lindberg

Journal: Microb Cell Fact

PubMed ID: 38369470

Doi: 10.1186/s12934-024-02330-3

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SPOP point mutations regulate substrate preference and affect its function

Authors: Yanran Deng, Wenhao Ding, Kaize Ma, Meixiao Zhan, Li Sun, Zizhang Zhou, Ligong Lu

Journal: Cell Death Dis

PubMed ID: 38409107

Doi: 10.1038/s41419-024-06565-1

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Design, quality and validation of the EU-OPENSCREEN fragment library poised to a high-throughput screening collection

Authors: Xavier Jalencas, Hannes Berg, Ludvik Olai Espeland, Sridhar Sreeramulu, Franziska Kinnen, Christian Richter, Charis Georgiou, Vladyslav Yadrykhinsky, Edgar Specker, Kristaps Jaudzems, Tanja Miletić, Robert Harmel, Phil Gribbon, Harald Schwalbe, Ruth Brenk, Aigars Jirgensons, Andrea Zaliani, Jordi Mestres

Journal: RSC Med Chem

PubMed ID: 38665834

Doi: 10.1039/d3md00724c

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Cystatin from the helminth upregulates mevalonate and cholesterol biosynthesis pathways and immunomodulatory genes in human monocyte-derived dendritic cells

Authors: Nathalie Acevedo, Ana Lozano, Josefina Zakzuk, Kevin Llinás-Caballero, David Brodin, Peter Nejsum, Andrew R Williams, Luis Caraballo

Journal: Front Immunol

PubMed ID: 38481989

Doi: 10.3389/fimmu.2024.1328401

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Searching for Frataxin Function: Exploring the Analogy with Nqo15, the Frataxin-like Protein of Respiratory Complex I from

Authors: Davide Doni, Eva Cavallari, Martin Ezequiel Noguera, Hernan Gustavo Gentili, Federica Cavion, Gustavo Parisi, Maria Silvina Fornasari, Geppo Sartori, Javier Santos, Massimo Bellanda, Donatella Carbonera, Paola Costantini, Marco Bortolus

Journal: Int J Mol Sci

PubMed ID: 38339189

Doi: 10.3390/ijms25031912

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Antibodies toward Na,HCO-cotransporter NBCn1/SLC4A7 block net acid extrusion and cause pH-dependent growth inhibition and apoptosis in breast cancer

Authors: Trine V Axelsen, Claus Olesen, Danish Khan, Ali Mohammadi, Elena V Bouzinova, Christine J F Nielsen, Marco Mele, Katrine R Hauerslev, Helene L Pedersen, Eva Balling, Pernille Vahl, Trine Tramm, Peer M Christiansen, Ebbe Boedtkjer

Journal: Br J Cancer

PubMed ID: 38310186

Doi: 10.1038/s41416-024-02591-0

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Biomimetic bacteria-derived nanoclusters enhance ferroptosis cancer immunotherapy through synergistic CRISPR-photothermo modulation

Authors: Xiuhua Pan , Jie Yang , Ruixin Kang , Jun Zhang , Zongwei Hu , Ning Yang , Zengyi Liu , Zengguang Jia , Xiawei Zhou , Qi Shen

Journal: Nano Today

Doi: 10.1016/j.nantod.2024.102213

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Bile salt hydrolase catalyses formation of amine-conjugated bile acids

Authors: Bipin Rimal, Stephanie L Collins, Ceylan E Tanes, Edson R Rocha, Megan A Granda, Sumeet Solanki, Nushrat J Hoque, Emily C Gentry, Imhoi Koo, Erin R Reilly, Fuhua Hao, Devendra Paudel, Vishal Singh 11, Tingting Yan 12, Min Soo Kim 2, Kyle Bittinger 3, Joseph P Zackular 13 14, Kristopher W Krausz 12, Dhimant Desai 15, Shantu Amin 15, James P Coleman 4, Yatrik M Shah 5, Jordan E Bisanz 2 16, Frank J Gonzalez 12, John P Vanden Heuvel 1 17, Gary D Wu 18, Babette S Zemel 3, Pieter C Dorrestein 7 8, Emily E Weinert 2 6, Andrew D Patterson 19 20 21

Journal: Nature

PubMed ID: 38326609

Doi: 10.1038/s41586-023-06990-w

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Harnessing eukaryotic retroelement proteins for transgene insertion into human safe-harbor loci

Authors: Xiaozhu Zhang, Briana Van Treeck, Connor A. Horton, Jeremy J. R. McIntyre, Sarah M. Palm, Justin L. Shumate & Kathleen Collins

Journal: Nat Biotechnol

PubMed ID: 38379101

Doi: 10.1038/s41587-024-02137-y

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Disordered regions mediate the interaction of p53 and MRE11

Authors: Sinem Usluer , Markus Galhuber , Yukti Khanna , Benjamin Bourgeois , Emil Spreitzer , Helene Michenthaler, Andreas Prokesch, Tobias Madl

Journal: Cell Research

PubMed ID: 38123020

Doi: 10.1016/j.bbamcr.2023.119654

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mTOR Regulates Mineralocorticoid Receptor Transcriptional Activity by ULK1-Dependent and -Independent Mechanisms

Authors: Yusuf Ali, Celso E Gomez-Sanchez, Maria Plonczynski, Aniko Naray-Fejes-Toth, Geza Fejes-Toth, Elise P Gomez-Sanchez

Journal: Endocrinology

PubMed ID: 38325289

Doi: 10.1210/endocr/bqae015

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Exploring the immunogenicity of Rv2201-519: A T-cell epitope-based antigen derived from Mycobacterium tuberculosis AsnB with implications for tuberculosis infection detection and vaccine development

Authors: Xiuli Luan, Xueting Fan, Guilian Li, Mchao Li, Na Li, Yuhan Yan, Xiuqin Zhao, Haican Liu, Kanglin Wan

Journal: Int Immunopharmacol

PubMed ID: 38342063

Doi: 10.1016/j.intimp.2024.111542

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Discovery of Two Novel Immunoepitopes and Development of Peptide-based Sarcoidosis Immunoassay

Authors: Changya Peng , Jaya Talreja , Brennen Steinbauer , Kazuhiko Shinki , Laura L Koth , Lobelia Samavati

Journal: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

PubMed ID: 38385694

Doi: 10.1164/rccm.202306-1054OC

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Comprehensive Genomic Analysis Identifies a Diverse Landscape of Sideroblastic and Nonsideroblastic Iron-Related Anemias with Novel and Pathogenic Variants in an Iron-Deficient Endemic Setting

Authors: Pankaj Sharma, Prateek Bhatia, Minu Singh, Manu Jamwal, Swetha Pallavelangini, Reena Das, Pankaj Malhotra, Savita V Attri, Sarah Ducamp, Mark D Fleming, Amita Trehan

Journal: J Mol Diagn

PubMed ID: 38360212

Doi: 10.1016/j.jmoldx.2024.01.011

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Stromal interaction molecule 1/microtubule-associated protein 1A/1B-light chain 3B complex induces metastasis of hepatocellular carcinoma by promoting autophagy

Authors: Jingchun Wang, Qichao Xie, Lei Wu, Yu Zhou, Yanquan Xu, Yu Chen, Jiangang Zhang, Ran Ren, Shiming Yang, Yongsheng Li, Huakan Zhao

Journal: MedComm (2020)

PubMed ID: 38344399

Doi: 10.1002/mco2.482

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A bioluminescent and homogeneous assay for monitoring GPCR-mediated cAMP modulation and PDE activity

Authors: Dareen Mikheil, Matthew A Larsen, Kevin Hsiao, Nathan H Murray, Tim Ugo, Hui Wang, Said A Goueli

Journal: Sci Rep

PubMed ID: 38396287

Doi: 10.1038/s41598-024-55038-0

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Gonococcal OMV-delivered PorB induces epithelial cell mitophagy

Authors: Shuai Gao, Lingyu Gao, Dailin Yuan, Xu'ai Lin, Stijn van der Veen

Journal: Nat Commun

PubMed ID: 38396029

Doi: 10.1038/s41467-024-45961-1

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SARS-CoV-2 targets ribosomal RNA biogenesis

Authors: V Talya Yerlici, Audrey Astori, Nevraj S Kejiou, Chris A Jordan, Negin Khosraviani, Janet N Y Chan, Razqallah Hakem, Brian Raught, Alexander F Palazzo, Karim Mekhail

Journal: Cell Rep

PubMed ID: 38427561

Doi: 10.1016/j.celrep.2024.113891

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Shrimp injection with dsRNA targeting the microsporidian EHP polar tube protein reduces internal and external parasite amplification

Authors: Satika Yuanlae, Tharinthon Prasartset, Onrapak Reamtong, Natthinee Munkongwongsiri, Muthita Panphloi, Thanchanok Preechakul, Rungkarn Suebsing, Siripong Thitamadee, Anuphap Prachumwat, Ornchuma Itsathitphaisarn, Suparat Taengchaiyaphum, Chanadda Kasamechotchung

Journal: Sci Rep

PubMed ID: 38413745

Doi: 10.1038/s41598-024-55400-2

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Engineering recombinant replication-competent bluetongue viruses expressing reporter genes for and non-invasive studies

Authors: Sergio Utrilla-Trigo, Luis Jiménez-Cabello, Alejandro Marín-López, Miguel Illescas-Amo, Germán Andrés, Eva Calvo-Pinilla, Gema Lorenzo, Piet A van Rijn, Javier Ortego, Aitor Nogales

Journal: Microbiol Spectr

PubMed ID: 38353566

Doi: 10.1128/spectrum.02493-23

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Rapid Decline of SARS-CoV-2 Viral Load in Single vs Double-Dose (Short-Interval <6 Weeks) ChAdOx nCoV-19 Vaccinated Health-Care Workers

Authors: Arnab Ghosh, Poonam Kanta, Manisha Ramola, Ritin Mohindra, Kapil Goyal, Roop Kishore, Vikas Suri, P V M Lakshmi, Chanderkanta Chauhan, Manisha Sharma, Partha Rakshit, Kalaiarasan Ponnusamy, Tanzin Dikid, Mini P Singh

Journal: Curr Microbiol

PubMed ID: 38353761

Doi: 10.1007/s00284-023-03603-7

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Site-Directed Mutagenesis of VvCYP76F14 (Cytochrome P450) Unveils Its Potential for Selection in Wine Grape Varieties Linked to the Development of Wine Bouquet

Authors: Bin Peng, Jianguo Ran, Yiyang Li, Meiling Tang, Huilin Xiao, Shengpeng Shi, Youzheng Ning, Adeeba Dark, Jin Li, Xueqiang Guan, Zhizhong Song

Journal: J Agric Food Chem

PubMed ID: 38334101

Doi: 10.1021/acs.jafc.3c09083

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Applying valency-based immuno-selection to generate broadly cross-reactive antibodies against influenza hemagglutinins

Authors: Daniëla Maria Hinke, Ane Marie Anderson, Kirankumar Katta, Marlene Fyrstenberg Laursen, Demo Yemane Tesfaye, Ina Charlotta Werninghaus, Davide Angeletti, Gunnveig Grødeland, Bjarne Bogen, Ranveig Braathen

Journal: Nat Commun

PubMed ID: 38346952

Doi: 10.1038/s41467-024-44889-w

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Advances and Challenges in SARS-CoV-2 Detection: A Review of Molecular and Serological Technologies

Authors:

Journal: Diagnostics (Basel)

PubMed ID: 38472991

Doi: 10.3390/diagnostics14050519

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Expression of GPX4 by oncolytic vaccinia virus can significantly enhance CD8T cell function and its impact against pancreatic ductal adenocarcinoma

Authors: Wei Wei, Linqing Tian, Xiaoyan Zheng, Lei Zhong, Yuan Chen, Hui Dong, Guibing Zhang, Shibing Wang, Xiangmin Tong

Journal: Oncoimmunology

PubMed ID: 38419758

Doi: 10.1080/2162402X.2024.2322173

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Evaluation of the therapeutic effect of a novel bacteriophage in the healing process of infected wounds with Klebsiella pneumoniae in mice

Authors: Fatemeh Zeynali Kelishomi, Farhad Nikkhahi, Samira Amereh, Fatemeh Ghayyaz, Seyed Mahmoud Amin Marashi, Amir Javadi, Gholamhassan Shahbazi, Mohadeseh Khakpour

Journal: J Glob Antimicrob Resist

PubMed ID: 38307250

Doi: 10.1016/j.jgar.2024.01.018

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Residues within the LptC transmembrane helix are critical for Escherichia coli LptB FG ATPase regulation

Authors: Nicholas P Cina, Dara W Frank, Candice S Klug

Journal: Protein Sci

PubMed ID: 38131105

Doi: 10.1002/pro.4879

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Structural and functional comparisons of salivary α-glucosidases from the mosquito vectors Aedes aegypti, Anopheles gambiae, and Culex quinquefasciatus

Authors: Adeline E Williams, Apostolos G Gittis, Karina Botello, Phillip Cruz, Ines Martin-Martin, Paola Carolina Valenzuela Leon, Benjamin Sumner, Brian Bonilla, Eric Calvo

Journal: Insect Biochem Mol Biol

PubMed ID: 38428508

Doi: 10.1016/j.ibmb.2024.104097

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The catalytic action of human d-lactate dehydrogenase is severely inhibited by oxalate and is impaired by mutations triggering d-lactate acidosis

Authors: Alessandra Stefan, Alberto Mucchi, Alejandro Hochkoeppler

Journal: Arch Biochem Biophys

PubMed ID: 38373542

Doi: 10.1016/j.abb.2024.109932

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Development and characterization of DIA 123, a fully human intact anti-CEACAM1 monoclonal antibody

Authors: Michela Centonze, Valentina Fiori, Maciej Kujawski, Lin Li, Patty Wong, Lindsay Williams, Tomas Di Mambro, Sabrina Dominici, Angelo Sparti, John E Shively, Mauro Magnani

Journal: PLoS ONE

PubMed ID: 38346003

Doi: 10.1371/journal.pone.0295345

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Aberrant Upregulation of RUNX3 Activates Developmental Genes to Drive Metastasis in Gastric Cancer

Authors: Kazuto Suda, Atsushi Okabe, Junichi Matsuo, Linda Shyue Huey Chuang, Ying Li, Nawaphat Jangphattananont, Naing Naing Mon, Khine Nyein Myint, Akihiro Yamamura, Jimmy Bok-Yan So, Dominic Chih-Cheng Voon, Henry Yang, Khay Guan Yeoh, Atsushi Kaneda, Yoshiaki Ito

Journal: Cancer Res Commun

PubMed ID: 38240752

Doi: 10.1158/2767-9764.CRC-22-0165

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Cloning and phylogenetic analysis of N protein gene from Rift Valley Fever Virus (RVFV)

Authors: Ahmed Mohamed Hassan, Arwa Ahmed Zehairy, Al-Judaibi Awatif Abid, Sayed Sartaj Sohrab, Ibraheem Azhar Esam

Journal: Bioinformation

PubMed ID: 38497067

Doi: 10.6026/973206300200091

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