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Mammalian PIWI–piRNA–target complexes reveal features for broad and efficient target silencing

Authors: Zhiqing Li, Zhenzhen Li, Yuqi Zhang, Lunni Zhou, Qikui Xu, Lili Li, Lin Zeng, Junchao Xue, Huilin Niu, Jing Zhong, Qilu Yu, Dengfeng Li, Miao Gui, Yongping Huang, Shikui Tu, Zhao Zhang, Chun-Qing Song, Jianping Wu，En-Zhi Shen

Journal: Nat Struct Mol Biol

PubMed ID: 38658622

Doi: 10.1038/s41594-024-01287-6.

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Structural basis of exoribonucleasemediated mRNA transcription termination

Authors: Yuan Zeng, Hong-Wei Zhang, Xiao-Xian Wu, Yu Zhang

Journal: Nature

PubMed ID: 38538796

Doi: doi.org/10.1038/s41586-024-07240-3

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Tailored UPRE2 variants for dynamic gene regulation in yeast

Authors: Chufan Xiao, Xiufang Liu, Yuyang Pan, Yanling Li, Ling Qin, Zhibo Yan, Yunzi Feng, Mouming Zhao, Mingtao Huang

Journal: Proc Natl Acad Sci U S A

PubMed ID: 38687789

Doi: 10.1073/pnas.2315729121

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Duration of antibody response to the receptor binding domain of SARS-CoV-2 in infected or vaccinated individuals - A one year retrospective cohort study

Authors: Martin Pasev, Angelina Trifonova, Andrey Velichkov, Velislava Terzieva

Journal: Int Immunopharmacol

PubMed ID: 38621337

Doi: 10.1016/j.intimp.2024.112084

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A long-acting FGF21 attenuates metabolic dysfunction-associated steatohepatitis-related fibrosis by modulating NR4A1-mediated Ly6C phenotypic switch in macrophages

Authors: Yue Ji, Yiliang Duan, Yuanyuan Li, Qingzhou Lu, Dingkang Liu, Yifan Yang, Ruilong Chang, Jing Tian, Wenbing Yao, Jun Yin, Xiangdong Gao

Journal: Br J Pharmacol

PubMed ID: 38679486

Doi: 10.1111/bph.16378

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Crosstalk interactions between transcription factors ERRα and PPARα assist PPARα-mediated gene expression

Authors: Sofie J Desmet, Jonathan Thommis, Tineke Vanderhaeghen, Edmee M F Vandenboorn, Dorien Clarisse, Yunkun Li, Steven Timmermans, Daria Fijalkowska, Dariusz Ratman, Evelien Van Hamme, Lode De Cauwer, Bart Staels, Luc Brunsveld, Frank Peelman, Claude Libert, Jan Tavernier, Karolien De Bosscher

Journal: Mol Metab

PubMed ID: 38631478

Doi: 10.1016/j.molmet.2024.101938

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HLA-C*04:09N is expressed at the cell surface and triggers peptide-specific T-cell activation

Authors: Carlotta Welters, Marthe-Lina Welters, Serena Stadler, Lars Bullinger, Julian Strobel, Holger Hackstein, Arunraj Dhamodaran, Thomas Blankenstein, Leo Hansmann

Journal: Haematologica

PubMed ID: 37767552

Doi: 10.3324/haematol.2023.283812

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Synthetic Peptides Selected by Immunoinformatics as Potential Tools for the Specific Diagnosis of Canine Visceral Leishmaniasis

Authors: Gabriel Moreira, Rodrigo Maia, Nathália Soares, Thais Ostolin, Wendel Coura-Vital, Rodrigo Aguiar-Soares, Jeronimo Ruiz, Daniela Resende, Rory de Brito, Alexandre Reis, Bruno Roatt

Journal: Microorganisms

PubMed ID: 38792746

Doi: 10.3390/microorganisms12050906

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Quantitation of Enterovirus A71 Empty and Full Particles by Sedimentation Velocity Analytical Ultracentrifugation

Authors: Anna Yang, Yun Luo, Jie Yang, Tingbo Xie, Wenhui Wang, Xin Wan, Kaiwen Wang, Deqin Pang, Dongsheng Yang, Hanyu Dai, Jie Wu, Shengli Meng, Jing Guo, Zejun Wang, Shuo Shen

Journal: Viruses

PubMed ID: 38675915

Doi: 10.3390/v16040573

Products & Services: Protein Electrophoresis and Western

Identification of PEX5-PTS1 Interaction Inhibitors through Fluorescence Polarization-Based High-Throughput Screening

Authors: Trong-Nhat Phan, Kyu-Ho Paul Park, David Shum, Joo Hwan No

Journal: Molecules

PubMed ID: 38675653

Doi: 10.3390/molecules29081835

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The nematode-trapping fungus Arthrobotrys oligospora detects prey pheromones via G protein-coupled receptors

Authors: Chih-Yen Kuo, Rebecca J Tay, Hung-Che Lin, Sheng-Chian Juan, Guillermo Vidal-Diez de Ulzurrun, Yu-Chu Chang, Jason Hoki, Frank C Schroeder, Yen-Ping Hsueh

Journal: Nat Microbiol

PubMed ID: 38649409

Doi: 10.1038/s41564-024-01679-w

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Antibody-blocking of a tick transporter impairs Anaplasma phagocytophilum colonization in Haemaphysalis longicornis ticks

Authors: Prachi Namjoshi, Donald M Lubembe, Hameeda Sultana, Girish Neelakanta

Journal: Sci Rep

PubMed ID: 38637614

Doi: 10.1038/s41598-024-59315-w

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Use of in silico approaches, synthesis and profiling of Pan-filovirus GP-1,2 preprotein specific antibodies

Authors: Maciej Wiśniewski, Peace Babirye, Carol Musubika, Eleni Papakonstantinou, Samuel Kirimunda, Michal Łaźniewski, Teresa Szczepińska, Moses L Joloba, Elias Eliopoulos, Erik Bongcam-Rudloff, Dimitrios Vlachakis, Anup Kumar Halder, Dariusz Plewczyński, Misaki Wayengera

Journal: Brief Funct Genomics

PubMed ID: 38605526

Doi: 10.1093/bfgp/elae012

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Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system

Authors: Lijie Guo, Pingping Huang, Zhaoxing Li, Young-Cheul Shin, Purui Yan, Meiling Lu, Meirong Chen, Yibei Xiao

Journal: Nat Chem Biol

PubMed ID: 37932527

Doi: 10.1038/s41589-023-01478-0

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Echinococcus granulosus ubiquitin-conjugating enzymes (E2D2 and E2N) promote the formation of liver fibrosis in TGFβ1-induced LX-2 cells

Authors: Xiaodi Du, Ruiqi Hua, Xue He, Wei Hou, Shengqiong Li, Aiguo Yang, Guangyou Yang

Journal: Parasit Vectors

PubMed ID: 38643149

Doi: 10.1186/s13071-024-06222-8

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Problems with paralogs: the promise and challenges of gene duplicates in evo-devo research

Authors: Kevin D Deem, Jennifer A Brisson

Journal: Integr Comp Biol

PubMed ID: 38565319

Doi: 10.1093/icb/icae009

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Buffer choice and pH strongly influence phase separation of SARS-CoV-2 nucleocapsid with RNA

Authors: Nina C Kathe, Mihajlo Novakovic, Frédéric H-T Allain

Journal: Mol Biol Cell

PubMed ID: 38568799

Doi: 10.1091/mbc.E23-12-0500

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Epitope mapping and a candidate vaccine design from canine distemper virus

Authors: Camila Pereira Dos Santos, Jerlane Tarcilia Gomes Telles, Georgia de Freitas Guimarães, Laura Helena Vega Gonzales Gil, Amanda Mota Vieira, Jose Wilton Pinheiro Junior, Carlos Eduardo Calzavara-Silva, Rita de Cássia CarvalhoMaia

Journal: Open Vet J

PubMed ID: 38808294

Doi: 10.5455/OVJ.2024.v14.i4.9

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Resistance mechanisms of SARS-CoV-2 3CLpro to the non-covalent inhibitor WU-04

Authors: Lijing Zhang, Xuping Xie, Hannan Luo, Runtong Qian, Yang Yang, Hongtao Yu, Jing Huang, Pei-Yong Shi, Qi Hu

Journal: Cell Discov

PubMed ID: 38594245

Doi: 10.1038/s41421-024-00673-0

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Analysis of the Immunogenicity of African Swine Fever F317L Protein and Screening of T Cell Epitopes

Authors: Ying Huang, Wenzhu Zhai, Zhen Wang, Yuheng He, Chunhao Tao, Yuanyuan Chu, Zhongbao Pang, Hongfei Zhu, Hong Jia

Journal: Animals (Basel)

PubMed ID: 38731330

Doi: 10.3390/ani14091331

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FOXO1 is a master regulator of memory programming in CAR T cells

Authors: Alexander E Doan, Katherine P Mueller, Andy Y Chen, Geoffrey T Rouin, Yingshi Chen, Bence Daniel, John Lattin, Martina Markovska, Brett Mozarsky, Jose Arias-Umana, Robert Hapke, In-Young Jung, Alice Wang, Peng Xu, Dorota Klysz, Gabrielle Zuern, Malek Bashti, Patrick J Quinn, Zhuang Miao, Katalin Sandor, Wenxi Zhang, Gregory M Chen, Faith Ryu, Meghan Logun, Junior Hall, Kai Tan, Stephan A Grupp, Susan E McClory, Caleb A Lareau, Joseph A Fraietta, Elena Sotillo, Ansuman T Satpathy, Crystal L Mackall, Evan W Weber

Journal: Nature

PubMed ID: 38600391

Doi: 10.1038/s41586-024-07300-8

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AKAP3-mediated type I PKA signaling is required for mouse sperm hyperactivation and fertility†

Authors: Zhongkun Liang, Chaowei Dai, Fenfen He, Yu Wang, Yihua Huang, Heying Li, Yongming Wu, Yafang Hu, Kaibiao Xu

Journal: Biol Reprod

PubMed ID: 38145487

Doi: 10.1093/biolre/ioad180

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Lysin and Lytic Phages Reduce Vibrio Counts in Live Feed and Fish Larvae

Authors: Jaime Romero, Sergueia Blas-Chumacero, Victoria Urzúa, Alejandro Villasante, Rafael Opazo, Felipe Gajardo, Claudio D Miranda, Rodrigo Rojas

Journal: Microorganisms

PubMed ID: 38792735

Doi: 10.3390/microorganisms12050904

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BRD2-specific inhibitor, BBC0403, inhibits the progression of osteoarthritis pathogenesis in osteoarthritis-induced C57BL/6 male mice

Authors: Hyemi Lee, Jiho Nam, Hahyeong Jang, Young-Sik Park, Min-Hee Son, In-Hyun Lee, Seong-Il Eyun, Jae-Hyun Yang, Jimin Jeon, Siyoung Yang

Journal: Br J Pharmacol

PubMed ID: 38600628

Doi: 10.1111/bph.16359

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Structural basis for the minimal bifunctional alginate epimerase AlgE3 from Azotobacter chroococcum

Authors: Takaaki Fujiwara, Eriko Mano, Eriko Nango

Journal: FEBS Lett

PubMed ID: 38649293

Doi: 10.1002/1873-3468.14886

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The hsa_circ_0082152 maintains NF-κB mRNA stability by binding to MTDH to promote anti-tuberculosis drug-induced liver injury

Authors: Lin Wang, Chunyan Meng, Yifei Long, Yue Liu, Luming Yang, Xuelei Gao, Shufeng Sun, Fumin Feng

Journal: Int J Biol Macromol

PubMed ID: 38670193

Doi: 10.1016/j.ijbiomac.2024.131793

Products & Services: Molecular Biology Reagents

The Ser/Thr protein kinase FonKin4-poly(ADP-ribose) polymerase FonPARP1 phosphorylation cascade is required for the pathogenicity of watermelon fusarium wilt fungus f sp

Authors: Jiajing Wang, Yizhou Gao, Xiaohui Xiong, Yuqing Yan, Jiajun Lou, Muhammad Noman, Dayong Li, Fengming Song

Journal: Front Microbiol

PubMed ID: 38690366

Doi: 10.3389/fmicb.2024.1397688

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Development of a novel monoclonal antibody-based competitive ELISA for antibody detection against bovine leukemia virus

Authors: Jing Wang, Chao Sun, Zhe Hu, Fang Wang, Jitao Chang, Ming Gao, Dandan Ye, Qi Jia, Hui Zou, Luc Willems, Zhigang Jiang, Xin Yin

Journal: Int J Biol Macromol

PubMed ID: 38621561

Doi: 10.1016/j.ijbiomac.2024.131446

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mA-dependent upregulation of DDX21 by super-enhancer-driven IGF2BP2 and IGF2BP3 facilitates progression of acute myeloid leukaemia

Authors: Yanchun Zhao, Yutong Zhou, Yu Qian, Wenwen Wei, Xiangjie Lin, Shihui Mao, Jie Sun, Jie Jin

Journal: Clin Transl Med

PubMed ID: 38572589

Doi: 10.1002/ctm2.1628

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OsATL32 ubiquitinates the reactive oxygen species-producing OsRac5-OsRbohB module to suppress rice immunity

Authors: Yuqing Yan, Hui Wang, Yan Bi, Jiajing Wang, Muhammad Noman, Dayong Li, Fengming Song

Journal: J Integr Plant Biol

PubMed ID: 38629772

Doi: 10.1111/jipb.13666

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Label-free detection of Aβ-42: a liquid crystal droplet approach for Alzheimer's disease diagnosis

Authors: Saumya Ranjan Pradhan, Ramadevi Suguru Pathinti, Ramesh Kandimalla, Krishnakanth Chithari, Madhava Rao Veeramalla N, Jayalakshmi Vallamkondu

Journal: RSC Adv

PubMed ID: 38628477

Doi: 10.1039/d4ra00615a

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Therapeutic application of circular RNA aptamers in a mouse model of psoriasis

Authors: Si-Kun Guo, Chu-Xiao Liu, Yi-Feng Xu, Xiao Wang, Fang Nan, Youkui Huang, Siqi Li, Shan Nan, Ling Li, Edo Kon, Chen Li, Meng-Yuan Wei, Rina Su, Jia Wei, Shiguang Peng, Nitay Ad-El, Jiaquan Liu, Dan Peer, Ting Chen, Li Yang, Ling-Ling Chen

Journal: Nat Biotechnol

PubMed ID: 38653797

Doi: 10.1038/s41587-024-02204-4

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An ultraviolet-driven rescue pathway for oxidative stress to eye lens protein human gamma-D crystallin

Authors: Jake A Hill, Yvonne Nyathi, Sam Horrell, David von Stetten, Danny Axford, Robin L Owen, Godfrey S Beddard, Arwen R Pearson, Helen M Ginn, Briony A Yorke

Journal: Commun Chem

PubMed ID: 38600176

Doi: 10.1038/s42004-024-01163-w

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CAR affinity modulates the sensitivity of CAR-T cells to PD-1/PD-L1-mediated inhibition

Authors: Irene Andreu-Saumell, Alba Rodriguez-Garcia, Vanessa Mühlgrabner, Marta Gimenez-Alejandre, Berta Marzal, Joan Castellsagué, Fara Brasó-Maristany, Hugo Calderon, Laura Angelats, Salut Colell, Mara Nuding, Marta Soria-Castellano, Paula Barbao, Aleix Prat, Alvaro Urbano-Ispizua, Johannes B Huppa, Sonia Guedan

Journal: Nat Commun

PubMed ID: 38670972

Doi: 10.1038/s41467-024-47799-z

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Edaravone Dexborneol mitigates pathology in animal and cell culture models of Alzheimer's disease by inhibiting neuroinflammation and neuronal necroptosis

Authors: Chong Xu, Yilan Mei, Ruihan Yang, Qiudan Luo, Jienian Zhang, Xiaolin Kou, Jianfeng Hu, Yujie Wang, Yue Li, Rong Chen, Zhengping Zhang, Yuyuan Yao, Jian Sima

Journal: Cell Biosci

PubMed ID: 38678262

Doi: 10.1186/s13578-024-01230-8

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Intratumoural delivery of TRAIL mRNA induces colon cancer cell apoptosis

Authors: Tingxuan Gu, Mengqiao Wang, Xiaorong Fu, Xueli Tian, Juanjuan Bi, Ning Lu, Chen Chen, Shijia Yan, Ang Li, Luyun Wang, Xiang Li, Kangdong Liu, Zigang Dong

Journal: Biomed Pharmacother

PubMed ID: 38636395

Doi: 10.1016/j.biopha.2024.116603

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Flow Cytometry-Based Measurement of Antibodies Specific for Cell Surface-Expressed Folded SARS-CoV-2 Receptor-Binding Domains

Authors: Al Nasar Ahmed Sehgal, Jera Safran, Bernhard Kratzer, Pia Gattinger, Robert B Stieger, Laszlo Musiejovsky, Doris Trapin, Paul Ettel, Ulrike Körmöczi, Arno Rottal, Kristina Borochova, Yulia Dorofeeva, Inna Tulaeva, Milena Weber, Katharina Grabmeier-Pfistershammer, Thomas Perkmann, Ursula Wiedermann, Rudolf Valenta, Winfried F Pickl

Journal: Vaccines (Basel)

PubMed ID: 38675759

Doi: 10.3390/vaccines12040377

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Circ_0087851 suppresses colorectal cancer malignant progression through triggering miR-593-3p/BAP1-mediated ferroptosis

Authors: Ming Huang, Ting Gao, Xianyong Chen, Junlei Yi, Xuan Zhou

Journal: J Cancer Res Clin Oncol

PubMed ID: 38642144

Doi: 10.1007/s00432-024-05643-3

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Role of G326 in Determining the Aggregation Propensity of R3 Tau Repeat: Insights from Studies on R1R3 Tau Construct

Authors: Allwin Ebenezer Sahayaraj, Arshad Abdul Vahid, Asmita Dhara, Ann Teres Babu, Vinesh Vijayan

Journal: J Phys Chem B

PubMed ID: 38676652

Doi: 10.1021/acs.jpcb.4c00123

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LncRNA BlncAD1 Modulates Bovine Adipogenesis by Binding to MYH10, PI3K/Akt Signaling Pathway, and miR-27a-5p/CDK6 Axis

Authors: Xin Li, Zhongyi Hou, Shengbo Meng, Qihui Jia, Shanshan Xing, Zhitong Wang, Mengjuan Chen, Huifen Xu, Ming Li, Hanfang Cai

Journal: J Agric Food Chem

PubMed ID: 38661523

Doi: 10.1021/acs.jafc.4c00165

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The Bifunctional Effects of Lactoferrin (LFcinB11) in Inhibiting Neural Cell Adhesive Molecule (NCAM) Polysialylation and the Release of Neutrophil Extracellular Traps (NETs)

Authors: Bo Lu, Si-Ming Liao, Shi-Jie Liang, Li-Xin Peng, Jian-Xiu Li, Xue-Hui Liu, Ri-Bo Huang, Guo-Ping Zhou

Journal: Int J Mol Sci

PubMed ID: 38731861

Doi: 10.3390/ijms25094641

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Constructing an Antibiotic-Free Protein Expression System for Ovalbumin Biosynthesis in Probiotic Nissle 1917

Authors: Cheng Liu, Xueqin Lv, Long Liu, Jianghua Li, Guocheng Du, Jian Chen, Yanfeng Liu

Journal: J Agric Food Chem

PubMed ID: 38574273

Doi: 10.1021/acs.jafc.4c00827

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Milligram-scale assembly and NMR fingerprint of tau fibrils adopting the Alzheimer's disease fold

Authors: Pu Duan, Nadia El Mammeri, Mei Hong

Journal: J Biol Chem

PubMed ID: 38679331

Doi: 10.1016/j.jbc.2024.107326

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Online monitoring of protein refolding in inclusion body processing using intrinsic fluorescence

Authors: Chika Linda Igwe, Don Fabian Müller, Florian Gisperg, Jan Niklas Pauk, Matthias Kierein, Mohamed Elshazly, Robert Klausser, Julian Kopp, Oliver Spadiut, Eva Přáda Brichtová

Journal: Anal Bioanal Chem

PubMed ID: 38573344

Doi: 10.1007/s00216-024-05249-1

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High expression of PPP1CC promotes NHEJ-mediated DNA repair leading to radioresistance and poor prognosis in nasopharyngeal carcinoma

Authors: Ping Feng, Ying Wang, Na Liu, Yanming Chen, Yujun Hu, Zilu Huang, Ya Liu, Shuohan Zheng, Tongchao Jiang, Xiang Xiao, Wei Dai, Peng Huang, Yunfei Xia

Journal: Cell Death Differ

PubMed ID: 38589496

Doi: 10.1038/s41418-024-01287-5

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Immune response profiles from humans experimentally exposed to bites

Authors: Fernanda Fortes de Araujo, Maha Abdeladhim, Clarissa Teixeira, Kelly Hummer, Matthew D Wilkerson, Roseanne Ressner, Ines Lakhal-Naouar, Michael W Ellis, Claudio Meneses, Saule Nurmukhambetova, Regis Gomes, W David Tolbert, George W Turiansky, Marzena Pazgier, Fabiano Oliveira, Jesus G Valenzuela, Shaden Kamhawi, Naomi Aronson

Journal: Front Immunol

PubMed ID: 38633260

Doi: 10.3389/fimmu.2024.1335307

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Identification of hyperthermophilic D-allulose 3-epimerase from Thermotoga sp and its application as a high-performance biocatalyst for D-allulose synthesis

Authors: Ji-Dong Shen, Bao-Ping Xu, Te-Li Yu, Yong-Xiang Fei, Xue Cai, Liang-Gang Huang, Li-Qun Jin, Zhi-Qiang Liu, Yu-Guo Zheng

Journal: Bioprocess Biosyst Eng

PubMed ID: 38676737

Doi: 10.1007/s00449-024-02989-3

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Corinthian Currants Promote the Expression of Paraoxonase-1 and Enhance the Antioxidant Status in Serum and Brain of 5xFAD Mouse Model of Alzheimer's Disease

Authors: Dimitris Lymperopoulos, Anastasia-Georgia Dedemadi, Maria-Lydia Voulgari, Eirini Georgiou, Ioannis Dafnis, Christina Mountaki, Eirini A Panagopoulou, Michalis Karvelas, Antonia Chiou, Vaios T Karathanos, Angeliki Chroni

Journal: Biomolecules

PubMed ID: 38672443

Doi: 10.3390/biom14040426

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Drp1 controls complex II assembly and skeletal muscle metabolism by Sdhaf2 action on mitochondria

Authors: Zhenqi Zhou, Alice Ma, Timothy M Moore, Dane M Wolf, Nicole Yang, Peter Tran, Mayuko Segawa, Alexander R Strumwasser, Wenjuan Ren, Kai Fu, Jonathan Wanagat, Alexander M van der Bliek, Rachelle Crosbie-Watson, Marc Liesa, Linsey Stiles, Rebecca Acin-Perez, Sushil Mahata, Orian Shirihai, Mark O Goodarzi, Michal Handzlik, Christian M Metallo, David W Walker, Andrea L Hevener

Journal: Sci Adv

PubMed ID: 38569044

Doi: 10.1126/sciadv.adl0389

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The Female-Biased General Odorant Binding Protein 2 of Displays Binding Affinity for Biologically Active Host Plant Volatiles

Authors: Jingjing Tu, Zehua Wang, Fan Yang, Han Liu, Guanghang Qiao, Aihuan Zhang, Shanning Wang

Journal: Biology (Basel)

PubMed ID: 38666886

Doi: 10.3390/biology13040274

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