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Time-dependent enhancement of mRNA vaccines by 4–1BB costimulation

Authors: Sarah Sanchez, Tanushree Dangi, Bakare Awakoaiye, Nahid Irani, Slim Fourati, Justin Richner, Pablo Penaloza-MacMaster

Journal: bioRxiv

PubMed ID: 38496467

Doi: 10.1101/2024.03.01.582992

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Enzymatic construction of a library of even- and odd-numbered heparosan oligosaccharides and their N-sulfonated derivatives

Authors: Xintong Xi, Weijiao Zhang, Litao Hu, Ruirui Xu, Yang Wang, Guocheng Du, Jian Chen, Zhen Kang

Journal: Int J Biol Macromol

PubMed ID: 38442831

Doi: 10.1016/j.ijbiomac.2024.130501

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Heterologous expression of taxane genes confers resistance to fall armyworm in Nicotiana benthamiana

Authors: Zhenlu Xu, Yaohua Zhai, Huimin Chang, Da Yan, Pengliang Ge, Guangming Ren, Lijun Zhang, Ye Yuan, Ruoyan Wang, Wentao Li, Fuguang Li, Maozhi Ren, Huijuan Mo

Journal: Plant Cell Rep

PubMed ID: 38472660

Doi: 10.1007/s00299-024-03169-z

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The LPS-inactivating enzyme acyloxyacyl hydrolase protects the brain from experimental stroke

Authors: Yuanbo Zhu, Yue Hu, Zhongwang Liu, Luping Chang, Xue Geng, Xuhui Yin, Bing-Qiao Zhao, Wenying Fan

Journal: Transl Res

PubMed ID: 38522823

Doi: 10.1016/j.trsl.2024.03.007

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Identification and expression analysis of family gene in L

Authors: Jiao Xu, Lingyang Kong, Weichao Ren, Zhen Wang, Lili Tang, Wei Wu, Xiubo Liu, Wei Ma, Shuquan Zhang

Journal: Heliyon

PubMed ID: 38545150

Doi: 10.1016/j.heliyon.2024.e27817

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Correction to "Subtilisin 3 production from Microsporum canis is independent of keratin substrate availability"

Authors:

Journal: J Basic Microbiol

PubMed ID: 38533930

Doi: 10.1002/jobm.202470023

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Identification of the grass carp interleukin-23 receptor and its proinflammatory role in intestinal inflammation

Authors: Panpan Han, Jian Tang, Xufang Xu, Pengkun Meng, Kang Wu, Bingyao Sun, Xuehong Song

Journal: Int J Biol Macromol

PubMed ID: 38521334

Doi: 10.1016/j.ijbiomac.2024.130946

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A long-term cohort study: the immune evasion and decreasing neutralization dominated the SARS-CoV-2 breakthrough infection

Authors: Qianyun Liu, Meihua Jin, Fanghua Mei, Hui Fan, Mengxue Gu, Yuzhen Zhang, Shengnan Qian, Xue Tan, Lei Ji, Zhen Zhang, Guozhong Chen, Huan Yan, Yu Chen, Ke Lan, Qing Geng, Kun Cai, Li Zhou

Journal: Front Cell Infect Microbiol

PubMed ID: 38572316

Doi: 10.3389/fcimb.2024.1381877

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Binding and Activation of LRP1-Dependent Cell Signaling in Schwann Cells Using a Peptide Derived from the Hemopexin Domain of MMP-9

Authors: John H Kim, Aashish Shivkumar, Masaki Norimoto, Sascha Castro Lingl, Christian Seitz, Rommie E Amaro, Steve L Gonias, Jerry Yang, Wendy M Campana

Journal: Biochemistry

PubMed ID: 38450612

Doi: 10.1021/acs.biochem.3c00705

Products & Services: Molecular Biology Reagents

Taraxasterol enhanced bladder cancer cells radiosensitivity via inhibiting the COX-2/PGE2/JAK2/STAT3/MMP pathway

Authors: Quanxin Wang, Ruiqi Zhang, Yijun He, Guangmin Mao, Zhaolu Kong

Journal: Int J Radiat Biol

PubMed ID: 38442139

Doi: 10.1080/09553002.2024.2324475

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The molecular mechanism and evolutionary divergence of caspase 3/7-regulated gasdermin E activation

Authors: Hang Xu, Zihao Yuan, Kunpeng Qin, Shuai Jiang , Li Sun

Journal: Elife

PubMed ID: 38489483

Doi: 10.7554/eLife.89974

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Transmission Reducing and Enhancing Monoclonal Antibodies against Plasmodium vivax Gamete Surface Protein Pvs48/45

Authors: Geetha P Bansal, Maisa da Silva Araujo, Yi Cao, Emily Shaffer, Jessica Evangelista Araujo, Jansen Fernandes Medeiros, Clifford Hayashi, Joseph Vinetz, Nirbhay Kumar

Journal: Infect Immun

PubMed ID: 38289124

Doi: 10.1128/iai.00374-23

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Efficient production of isomaltulose using engineered Yarrowia lipolytica strain facilitated by non-yeast signal peptide-mediated cell surface display

Authors: Juanjuan Liu, Jiao Li, Peng Chen, Yan Zeng, Jiangang Yang, Yuanxia Sun

Journal: J Sci Food Agric

PubMed ID: 38436580

Doi: 10.1002/jsfa.13426

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De Novo Multienzyme Synthetic Pathways for Lactic Acid Production

Authors: Xu-Wei Ding, Jing Rong, Ze-Peng Pan, Xin-Xin Zhu, Zhen-Yu Zhu, Qi Chen, Zhi-Jun Zhang, Jian-He Xu, Chun-Xiu Li, and Gao-Wei Zheng

Journal: ACS Catal

Doi: doi.org/10.1021/acscatal.3c05489

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lncCPSET1 acts as a scaffold for MLL2/COMPASS to regulate Bmp4 and promote the formation of chicken primordial germ cells

Authors: Ying Ding, Chen Zhang, Qisheng Zuo, Kai Jin, Bichun Li

Journal: Mol Genet Genomics

PubMed ID: 38551742

Doi: 10.1007/s00438-024-02127-4

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A novel conditional active biologic anti-EpCAM x anti-CD3 bispecific antibody with synergistic tumor selectivity for cancer immunotherapy

Authors: Gerhard Frey, Ana Paula G Cugnetti, Haizhen Liu, Charles Xing, Christina Wheeler, Hwai Wen Chang, William J Boyle, Jay M Short

Journal: MAbs

PubMed ID: 38445633

Doi: 10.1080/19420862.2024.2322562

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Mt10 Vaccine Protects Diversity Outbred Mice from CVB3 Infection by Producing Virus-Specific Neutralizing Antibodies and Diverse Antibody Isotypes

Authors: Mahima T Rasquinha, Kiruthiga Mone, Meghna Sur, Ninaad Lasrado, Chandirasegaran Massilamany, Stephen D Kachman, David Steffen, Jay Reddy

Journal: Vaccines (Basel)

PubMed ID: 38543901

Doi: 10.3390/vaccines12030266

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ADAMTS5 Promotes Permeability of the Blood-Brain Barrier during Subspecies Invading the Central Nervous System

Authors: Zuoxi Chen, Fangzhi Du, Ruihua Zhang, Qingyun Wu, Zhiyu Lu, Rui-Li Zhang, Qianqiu Wang

Journal: ACS Infect Dis

PubMed ID: 38536197

Doi: 10.1021/acsinfecdis.3c00664

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ENGINEERED NANOBODIES WITH PROGRAMMABLE TARGET ANTIGEN PROTEOLYSIS (PTAP) FUSIONS REGULATE INTRACELLULAR ALPHA-SYNUCLEIN IN VITRO AND IN VIVO

Authors: Diptaman Chatterjee, Lianna Y D'Brant, Benjamin M Hiller, David J Marmion, Ivette M Sandoval, Kelvin C Luk, Fredric P Manfredsson, Anne Messer, Jeffrey H Kordower, David C Butler

Journal: Res Sq

PubMed ID: 38585932

Doi: 10.21203/rs.3.rs-4088206/v1

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Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1

Authors: Xiong Xie, Qiaoshuai Lan, Jinyi Zhao, Sulin Zhang, Lu Liu, Yumin Zhang, Wei Xu, Maolin Shao, Jingjing Peng, Shuai Xia, Yan Zhu, Keke Zhang, Xianglei Zhang, Ruxue Zhang, Jian Li, Wenhao Dai, Zhen Ge, Shulei Hu, Changyue Yu, Jiang Wang, Dakota Ma, Mingyue Zheng, Haitao Yang, Gengfu Xiao, Zihe Rao, Lu Lu, Leike Zhang, Fang Bai, Yao Zhao, Shibo Jiang, Hong Liu

Journal: Signal Transduct Target Ther

PubMed ID: 38443334

Doi: 10.1038/s41392-024-01758-8

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Microfluidic Synthesis of Scalable Layer-by-Layer Multiple Antigen Nano-Delivery Platform for SARS-CoV-2 Vaccines

Authors: Yang Xu, Kazuya Masuda, Christine Groso, Rick Hassan, Ziyou Zhou, Kelsey Broderick, Moriya Tsuji, Christopher Tison

Journal: Vaccines (Basel)

PubMed ID: 38543973

Doi: 10.3390/vaccines12030339

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Evaluating microcystinase A-based approach on microcystins degradation during harvested cyanobacterial blooms

Authors: Siyu Yang, Jun Zuo, Hans-Peter Grossart, Guofei Dai, Jin Liu, Lirong Song, Nanqin Gan

Journal: Environ Pollut

PubMed ID: 38548158

Doi: 10.1016/j.envpol.2024.123878

Products & Services: Molecular Biology Reagents

Adaptive Darwinian off-target resistance mechanisms to selective RET inhibition in RET driven cancer

Authors: Vivek Subbiah, Mohamed A Gouda, J Bryan Iorgulescu, Ramona Dadu, Keyur Patel, Steven Sherman, Maria Cabanillas, Mimi Hu, Luz E Castellanos, Behrang Amini, Funda Meric-Bernstam, Tao Shen, Jie Wu

Journal: NPJ Precis Oncol

PubMed ID: 38438731

Doi: 10.1038/s41698-024-00563-4

Products & Services: Molecular Biology Reagents

Nanopore analysis of salvianolic acids in herbal medicines

Authors: Pingping Fan, Shanyu Zhang, Yuqin Wang, Tian Li, Hanhan Zhang, Panke Zhang, Shuo Huang

Journal: Nat Commun

PubMed ID: 38443335

Doi: 10.1038/s41467-024-45543-1

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A network pharmacological approach for the identification of potential therapeutic targets of - a complex traditional Siddha formulation

Authors: Agnes Preethy H, Yanamandram Balasubramanian Venkatakrishnan, Vigneshwar Ramakrishnan, Uma Maheswari Krishnan

Journal: J Biomol Struct Dyn

PubMed ID: 38459935

Doi: 10.1080/07391102.2024.2322612

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The eukaryotic-like characteristics of small GTPase, roadblock and TRAPPC3 proteins from Asgard archaea

Authors: Linh T Tran, Caner Akıl, Yosuke Senju, Robert C Robinson

Journal: Commun Biol

PubMed ID: 38472392

Doi: 10.1038/s42003-024-05888-1

Products & Services: DNA Sequencing

Design and synthesis of APN and 3CLpro dual-target inhibitors based on STSBPT with anticoronavirus activity

Authors: Youle Zheng, Jin Feng, Yanbin Song, Yixin Yu, Min Ling, Mengjia Zhang, Haijiao Xie, Wentao Li

Journal: J Med Virol

PubMed ID: 38483056

Doi: 10.1002/jmv.29512

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miR396b/GRF6 module contributes to salt tolerance in rice

Authors: Huanran Yuan, Mingxing Cheng, Ruihua Wang, Zhikai Wang, Fengfeng Fan, Wei Wang, Fengfeng Si, Feng Gao, Shaoqing Li

Journal: Plant Biotechnol J

PubMed ID: 38454780

Doi: 10.1111/pbi.14326

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Design of amyloidogenic peptide traps

Authors: Danny D Sahtoe, Ewa A Andrzejewska, Hannah L Han, Enrico Rennella, Matthias M Schneider, Georg Meisl, Maggie Ahlrichs, Justin Decarreau, Hannah Nguyen, Alex Kang, Paul Levine, Mila Lamb, Xinting Li, Asim K Bera, Lewis E Kay, Tuomas P J Knowles, David Baker

Journal: Nature Chemical Biology

PubMed ID: 38503834

Doi: 10.1038/s41589-024-01578-5

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Structure of the human KMN complex and implications for regulation of its assembly

Authors: Soumitra Polley, Tobias Raisch, Sabrina Ghetti, Marie Körner, Melina Terbeck, Frauke Gräter, Stefan Raunser, Camilo Aponte-Santamaría, Ingrid R Vetter, Andrea Musacchio

Journal: NATURE STRUCTURAL & MOLECULAR BIOLOGY

PubMed ID: 38459128

Doi: 10.1038/s41594-024-01230-9

Products & Services: Peptide Synthesis

Characterization of c-di-AMP signaling in the periodontal pathobiont, Treponema denticola

Authors: Aidan D Moylan, Dhara T Patel, Claire O'Brien, Edward J A Schuler, Annie N Hinson, Richard T Marconi, Daniel P Miller

Journal: Mol Oral Microbiol

PubMed ID: 38436552

Doi: 10.1111/omi.12458

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Machine learning developed a CD8 exhausted T cells signature for predicting prognosis, immune infiltration and drug sensitivity in ovarian cancer

Authors: Rujun Chen, Yicai Zheng, Chen Fei, Jun Ye, He Fei

Journal: Sci Rep

PubMed ID: 38461331

Doi: 10.1038/s41598-024-55919-4

Products & Services: Molecular Biology Reagents

Safety and immunogenicity of CoronaVac and ChAdOx1 heterologous prime-boost vaccines in an overweight population in Chiang Mai, Thailand

Authors: Kriangkrai Chawansuntati, Supachai Sakkhachornphop, Sayamon Hongjaisee, Saranta Freeouf, Patumrat Sripan, Nattaya Nusartsang, Romanee Chaiwarith, Tavitiya Sudjaritruk, Khuanchai Supparatpinyo, Jiraprapa Wipasa

Journal: Vaccine X

PubMed ID: 38549951

Doi: 10.1016/j.jvacx.2024.100475

Products & Services: Molecular Biology Reagents

Mosquito E-20-Monooxygenase Gene Knockout Increases Dengue Virus Replication in Cells

Authors: Bo Li, Di Wang, Xiaoxue Xie, Xiaoli Chen, Guorui Liang, Dan Xing, Teng Zhao, Jiahong Wu, Xinyu Zhou, Chunxiao Li

Journal: Viruses

PubMed ID: 38675868

Doi: 10.3390/v16040525

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Isobaric Tags for Relative and Absolute Quantitation-Based Proteomics Analysis Revealed Proteins Involved in Drought Response during the Germination Stage in Faba Bean

Authors: Changyan Liu, Fangwen Yang, Li Li, Xuesong Han, Hongwei Chen, Aihua Sha, Chunhai Jiao

Journal: Metabolites

PubMed ID: 38535335

Doi: 10.3390/metabo14030175

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Analysis of Recombinant Proteins for the Serological Diagnosis of Dourine

Authors: Mirella Luciani, Gisella Armillotta, Tiziana Di Febo, Ivanka Krasteva, Simonetta Ulisse, Chiara Di Pancrazio, Caterina Laguardia, Fabrizia Perletta, Anna Serroni, Marta Maggetti, Lilia Testa, Flavio Sacchini, Mariangela Iorio, Diamante Rodomonti, Manuela Tittarelli, Maria Teresa Mercante

Journal: Vet Sci

PubMed ID: 38535861

Doi: 10.3390/vetsci11030127

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The scale of zebrafish pectoral fin buds is determined by intercellular K+ levels and consequent Ca2+-mediated signaling via retinoic acid regulation of Rcan2 and Kcnk5b

Authors: Xiaowen Jiang, Kun Zhao, Yi Sun, Xinyue Song, Chao Yi, Tianlong Xiong, Sen Wang, Yi Yu, Xiduo Chen, Run Liu, Xin Yan, Christopher L Antos

Journal: PLoS Biol

PubMed ID: 38527087

Doi: journal.pbio.3002565

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Is there an immunological cross-reactivity of antibodies to the myelin oligodendrocyte glycoprotein and coronaviruses?

Authors: Kathrin Schanda, Sara Mariotto, Dagmar Rudzki, Angelika Bauer, Alessandro Dinoto, Patrizia Rossi, Sergio Ferrari, Sven Jarius, Brigitte Wildemann, Federica Boso, Bruno Giometto, Daniel Engels, Tania Kümpfel, Eva-Maria Wendel, Kevin Rostasy, Markus Reindl

Journal: Brain Commun

PubMed ID: 38576796

Doi: 10.1093/braincomms/fcae106

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miR-101-3p-mediated role of PDZK1 in hepatocellular carcinoma progression and the underlying PI3K/Akt signaling mechanism

Authors: Huihui Gao, Zhaofeng Gao, Xiaobei Liu, Xu Sun, Zhonghui Hu, Zhengwei Song, Cheng Zhang, Jianguo Fei, Xiaoguang Wang

Journal: Cell Div

PubMed ID: 38532426

Doi: 10.1186/s13008-023-00106-6

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An optimized high-throughput SARS-CoV-2 dual reporter trans-complementation system for antiviral screening in vitro and in vivo

Authors: Yingjian Li, Xue Tan, Jikai Deng, Xuemei Liu, Qianyun Liu, Zhen Zhang, Xiaoya Huang, Chao Shen, Ke Xu, Li Zhou, Yu Chen

Journal: Virol Sin

PubMed ID: 38548102

Doi: 10.1016/j.virs.2024.03.009

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Evaluation of Long-Term Adaptive Immune Responses Specific to SARS-CoV-2: Effect of Various Vaccination and Omicron Exposure

Authors: Hyunhye Kang, Jin Jung, Geon Young Ko, Jihyun Lee, Eun-Jee Oh

Journal: Vaccines (Basel)

PubMed ID: 38543935

Doi: 10.3390/vaccines12030301

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Accelerating BRPF1b hit identification with BioPhysical and Active Learning Screening (BioPALS)

Authors: Sandeep Pal, Zandile Nare, Vincenzo A Rao, Brian O Smith, Ian Morrison, Edward A Fitzgerald, Andrew Scott, Matilda J Bingham, Thomas Pesnot

Journal: ChemMedChem

PubMed ID: 38372199

Doi: 10.1002/cmdc.202300590

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miRNA circuit modules for precise, tunable control of gene expression

Authors: Rongrong Du, Michael J Flynn, Monique Honsa, Ralf Jungmann, Michael B Elowitz

Journal: biorxiv

PubMed ID: 38559239

Doi: 10.1101/2024.03.12.583048

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Porcine HERC6 acts as major E3 ligase for ISGylation and is auto-ISGylated for effective ISGylation in porcine

Authors: Cuiyu Ba, Chaonan Tian, Xueying Bo, Chang Xu, Yi Zhang, Xiangyu Sun, Yuchen Nan, Chunyan Wu

Journal: Microb Pathog

PubMed ID: 38554778

Doi: 10.1016/j.micpath.2024.106633

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FANCJ promotes PARP1 activity during DNA replication that is essential in BRCA1 deficient cells

Authors: Ke Cong, Nathan MacGilvary, Silviana Lee, Shannon G MacLeod, Jennifer Calvo, Min Peng, Arne Nedergaard Kousholt, Tovah A Day, Sharon B Cantor

Journal: Nat Commun

PubMed ID: 38521768

Doi: 10.1038/s41467-024-46824-5

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Near-cognate tRNAs increase the efficiency and precision of pseudouridine-mediated readthrough of premature termination codons

Authors: Nan Luo, Qiang Huang, Liting Dong, Wenqing Liu, Jinghui Song, Hanxiao Sun, Hao Wu, Yuan Gao, Chengqi Yi

Journal: Nat Biotechnol

PubMed ID: 38448662

Doi: 10.1038/s41587-024-02165-8

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The aged microenvironment impairs BCL6 and CD40L induction in CD4 T follicular helper cell differentiation

Authors: Jacob S Fisher, Irene Adán-Barrientos, Naveen R Kumar, Jessica N Lancaster