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Nuclear Magnetic Resonance based fragment screen of the E3 ligase Fem 1 homolog B

Authors: Jade M. Katinas; Kangsa Amporndanai; Ashley J. Taylor; Kristie L. Rose; Peter C. Gareiss; Roberto A. Crespo; Jason Phan; Alex G. Waterson; Stephen W. Fesik

Journal: Protein science : a publication of the Protein Society

PubMed ID: 41229306

Doi: 10.1002/pro.70365

Context dependent activity of p63-bound gene regulatory elements

Authors: Abby A McCann, Gabriele Baniulyte, Dana L Woodstock, Morgan A Sammons

Journal: biorxiv

PubMed ID: 38766006

Doi: 10.1101/2024.05.09.593326

Products & Services: Gene Synthesis

Structural and functional characterization of IgG- and non-IgG-based T-cell-engaging bispecific antibodies

Authors: Nishant Mohan, Safiat Ayinde, Hanjing Peng, Shraboni Dutta, Yi Shen, Vincent M Falkowski, Thomas G Biel, Tongzhong Ju, Wen Jin Wu

Journal: Front Immunol

PubMed ID: 38863707

Doi: 10.3389/fimmu.2024.1376096

Products & Services: Protein and Antibody Isolation

LncRNA CCRR maintains Ca homeostasis against myocardial infarction through the FTO-SERCA2a pathway

Authors: Hua Yang, Lina Xuan, Shengjie Wang, Huishan Luo, Xiaomeng Duan, Jianjun Guo, Shijia Cui, Jieru Xin, Junwei Hao, Xiufang Li, Jun Chen, Feihan Sun, Xiaolin Hu, Siyun Li, Ying Zhang, Lei Jiao, Baofeng Yang, Lihua Sun

Journal: Sci China Life Sci

PubMed ID: 38761356

Doi: 10.1007/s11427-023-2527-5

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Conditional knockdown of OsMLH1 to improve plant prime editing systems without disturbing fertility in rice

Authors: Xiaoshuang Liu, Dongfang Gu, Yiru Zhang, Yingli Jiang, Zhi Xiao, Rongfang Xu, Ruiying Qin, Juan Li, Pengcheng Wei

Journal: Genome Biol

PubMed ID: 38773623

Doi: 10.1186/s13059-024-03282-y

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Functional characterization of a novel flavin reductase from a deep-sea sediment metagenomic library and its application for indirubin production

Authors: Jikun Du, Yuanhua Li, Zhengzhuang Chen, Chang Wang, Yali Huang, Li Li

Journal: Appl Environ Microbiol

PubMed ID: 38780258

Doi: 10.1128/aem.00429-24

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and analysis reveal impact of c-Myc tag in FMC63 scFv-CD19 protein interface and CAR-T cell efficacy

Authors: Ana Julia Ferreira Lima, Karina Lobo Hajdu, Luiza Abdo, Leonardo Ribeiro Batista-Silva, Clara de Oliveira Andrade, Eduardo Mannarino Correia, Emmanuel Arthur Albuquerque Aragão, Martín Hernán Bonamino, Marcos Roberto Lourenzoni

Journal: Comput Struct Biotechnol J

PubMed ID: 38873646

Doi: 10.1016/j.csbj.2024.05.032

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CircRNA SEC24A promotes osteoarthritis through miR-107-5p/CASP3 axis

Authors: Tuerxunjiang Dadihanc, Yong Zhang, Guo-Qing Li, Hai-Kang Zhou, Jingyong Huang, Xue Zhang, Zhi-Qiang Li, Hai-Rong Ma

Journal: Regen Ther

PubMed ID: 38828010

Doi: 10.1016/j.reth.2024.04.011

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Legionella maintains host cell ubiquitin homeostasis by effectors with unique catalytic mechanisms

Authors: Jiaqi Fu, Siying Li, Hongxin Guan, Chuang Li, Tao-Tao Chen, Wei Xian, Zhengrui Zhang, Yao Liu, Qingtian Guan, Jingting Wang, Qiuhua Lu, Lina Kang, Si-Ru Zheng, Jinyu Li, Shoujing Cao, Chittaranjan Das, Xiaoyun Liu, Lei Song, Songying Ouyang, Zhao-Qing Luo

Journal: Res Sq

PubMed ID: 38826349

Doi: 10.21203/rs.3.rs-4431542/v1

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Characterization of Esterase Capable of Hydrolyzing Bis(2-hydroxyethyl) Terephthalate

Authors: Sizhong Feng, Mengke Xue, Fang Xie, Hongyang Zhao, Yemin Xue

Journal: J Agric Food Chem

PubMed ID: 38753963

Doi: 10.1021/acs.jafc.4c01973

Products & Services: Gene Synthesis

Hybrid Cas12a Variants with Relaxed PAM Requirements Expand Genome Editing Compatibility

Authors: Zhenyu Liu, Huayi Liu, Chaoqun Huang, Qun Zhou, Yunzi Luo

Journal: ACS Synth Biol

PubMed ID: 38819403

Doi: 10.1021/acssynbio.4c00103

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A "One-Step" Strategy for the Global Characterization of Core-Fucosylated Glycoproteome

Authors: Yuqiu Wang, Rui Yuan, Bo Liang, Jing Zhang, Qin Wen, Hongxu Chen, Yinping Tian, Liuqing Wen, Hu Zhou

Journal: JACS Au

PubMed ID: 38818065

Doi: 10.1021/jacsau.4c00214

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One-pot sustainable synthesis of glucosylglycerate from starch and glycerol through artificial in vitro enzymatic cascade

Authors: Juanjuan Liu, Mengfei Ren, Haoran Ma, Huilin Zhang, Xinyu Cui, Runyuan Kang, Xinming Feng, Dongdong Meng

Journal: Bioresour Technol

PubMed ID: 38508282

Doi: 10.1016/j.biortech.2024.130611

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Wheat peptide alleviates DSS-induced colitis by activating the Keap1-Nrf2 signaling pathway and maintaining the integrity of the gut barrier

Authors: Wen-Yin Xie, Zhong-Hao Ji, Wen-Zhi Ren, Pei-Sen Zhao, Fan-Hao Wei, JinPing Hu, Bao Yuan, Wei Gao

Journal: Food Funct .

PubMed ID: 38690672

Doi: 10.1039/d3fo04413k.

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Innervation of nociceptor neurons in the spleen promotes germinal center responses and humoral immunity

Authors: Min Wu, Guangping Song, Jianing Li, Zengqing Song, Bing Zhao, Liyun Liang, Wenlong Li, Huaibin Hu, Haiqing Tu, Sen Li, Peiyao Li, Biyu Zhang , Wen Wang, Yu Zhang , Wanpeng Zhang, Weifan Zheng, Jiarong Wang, Yuqi Wen, Kai Wang, Ailing Li, Tao Zhou, Yucheng Zhang, Huiyan Li

Journal: Cell

Doi: 10.1016/j.cell.2024.04.027

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Development of advanced control material for reverse transcription-mediated bacterial nucleic acid amplification tests

Authors: Janessa D Lewis , Stephen J Salipante

Journal: J Clin Microbiol

PubMed ID: 38629844

Doi: 10.1128/jcm.00243-24

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CRISPR/Cas13a-based supersensitive circulating tumor DNA assay for detecting EGFR mutations in plasma

Authors: Li Wang , Xiaosha Wen , Yang Yang , Zheng Hu , Jing Jiang , Lili Duan , Xiaofen Liao , Yan He , Yaru Liu , Jing Wang , Zhikun Liang , Xiaoya Zhu , Quan Liu , Tiancai Liu , Dixian Luo

Journal: Commun Biol

PubMed ID: 38806596

Doi: 10.1038/s42003-024-06368-2

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The TIMELESS and PARP1 interaction suppresses replication-associated DNA gap accumulation

Authors: Joanne Saldanha , Julie Rageul , Jinal A Patel , Amy L Phi , Natalie Lo , Jennifer J Park , Hyungjin Kim

Journal: Nucleic Acids Res

PubMed ID: 38801073

Doi: 10.1093/nar/gkae445.

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Functional Application of the Single-Module NRPS-like D-Alanyltransferase in Maytansinol Biosynthesis

Authors: Zhongyue Li, Zhonghang Zhu, Guangsen Xu, Lin Wei, Jiang Liu, Haoxin Wang, Chunhua Lu, Yaoyao Li, Deyu Zhu*, and Yuemao Shen

Journal: ACS Catal

Doi: 10.1021/acscatal.4c00082

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Helicases DDX5 and DDX17 promote heterogeneity in HBV transcription termination in infected human hepatocytes

Authors: Fleur Chapus 1, Guillaume Giraud 2, Pélagie Huchon 3, Mélanie Rodà 2, Xavier Grand 2, Caroline Charre 4, Chloé Goldsmith 5, Armando Andres Roca Suarez 2, Maria-Guadalupe Martinez 1, Judith Fresquet 6, Audrey Diederichs 3, Maëlle Locatelli 1, Hélène Polvèche 7, Caroline Scholtès 8, Isabelle Chemin 2, Hector Hernandez Vargas 5, Michel Rivoire 9, Cyril F Bourgeois 10, Fabien Zoulim 11, Barbara Testoni 12

Journal: J Hepatol

PubMed ID: 38782119

Doi: doi: 10.1016/j.jhep.2024.05.016.

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Aβ and ROS dual-targeted multifunctional nanocomposite for combination therapy of Alzheimer's disease

Authors: Liding Zhang, Kai Cao, Jun Xie, Xiaohan Liang, Hui Gong, Qingming Luo, Haiming Luo

Journal: J Nanobiotechnology

PubMed ID: 38783363

Doi: 10.1186/s12951-024-02543-z

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The 6-kilodalton peptide 1 in plant viruses of the family Potyviridae is a viroporin

Authors: Mengzhu Chai, Lei Li, Yong Li, Yingshuai Yang, Yuting Wang, Xue Jiang, Yameng Luan, Fangfang Li, Hongguang Cui, Aiming Wang, Wensheng Xiang, Xiaoyun Wu, Xiaofei Cheng

Journal: Proc Natl Acad Sci U S A

PubMed ID: 38739789

Doi: 10.1073/pnas.2401748121

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Bazi Bushen alleviates reproductive aging in aged male mice

Authors: Kun Ma, Mengnan Li, Yahui Song, Xinjing Mao, Shaolan Zhang, Yaping Zhang, Yuning Jiang, Chuanyuan Ji, Kunxu Niu, Hongrong Li, Yunlong Hou, Cong Wei

Journal: Chin J Nat Med

PubMed ID: 38796215

Doi: 10.1016/S1875-5364(24)60639-4

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Virus-like particle-based multipathogen vaccine of FMD and SVA elicits balanced and broad protective efficacy in mice and pigs

Authors: Hetao Song, Sahibzada Waheed Abdullah, Shuanghui Yin, Hu Dong, Yun Zhang, Shuzhen Tan, Manyuan Bai, Yaozhong Ding, Zhidong Teng, Shiqi Sun, Huichen Guo

Journal: Vaccine

PubMed ID: 38714448

Doi: 10.1016/j.vaccine.2024.04.092

Products & Services: Molecular Biology Reagents

POLR2J expression promotes glioblastoma malignancy by regulating oxidative stress and the STAT3 signaling pathway

Authors: Xiao-Li Zheng, Zhi-Di Li, Kai-Zhi Luo, Yang-Ling Li, Ye-Han Liu, Shu-Ying Shen, Fei-Yan Shen, Wan-Yan Li, Guo-Qing Chen, Chong Zhang, Ling-Hui Zeng

Journal: Am J Cancer Res

PubMed ID: 38859843

Doi: 10.62347/JEWM7691

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Functional characterization of the InR/PI3K/AKT signaling pathway in female reproduction of the predatory bug Cyrtorhinus lividipennis (Hemiptera: Miridae)

Authors: Kui Hu, Rong Jin, Jianqi Liu, Jun Zhu, Wei Dai, Ying Wang, Yao Li, Fang Liu

Journal: J Econ Entomol

PubMed ID: 38783398

Doi: 10.1093/jee/toae113

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Alpha and gamma mangostins inhibit wild-type B SARS-CoV-2 more effectively than the SARS-CoV-2 variants and the major target is unlikely the 3C-like protease

Authors: Aphinya Suroengrit, Van Cao, Patcharin Wilasluck, Peerapon Deetanya, Kittikhun Wangkanont, Kowit Hengphasatporn, Ryuhei Harada, Supakarn Chamni, Asada Leelahavanichkul, Yasuteru Shigeta, Thanyada Rungrotmongkol, Supot Hannongbua, Warinthorn Chavasiri, Supaporn Wacharapluesadee, Eakachai Prompetchara, Siwaporn Boonyasuppayakorn

Journal: Heliyon

PubMed ID: 38867992

Doi: 10.1016/j.heliyon.2024.e31987

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Discovery of UMI-77 as a novel Ku70/80 inhibitor sensitizing cancer cells to DNA damaging agents in vitro and in vivo

Authors: Xuening Chen, Changkun Chen, Chengmiao Luo, Jianyong Liu, Zhonghui Lin

Journal: Eur J Pharmacol

PubMed ID: 38754534

Doi: 10.1016/j.ejphar.2024.176647

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Structural basis of human mpox viral DNA replication inhibition by brincidofovir and cidofovir

Authors: Yunxia Xu, Yaqi Wu, Xiaoying Wu, Yuanyuan Zhang, Yaxue Yang, Danyang Li, Biao Yang, Kaiting Gao, Zhengyu Zhang, Changjiang Dong

Journal: Int J Biol Macromol

PubMed ID: 38735603

Doi: 10.1016/j.ijbiomac.2024.132231

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but not is the avirulence determinant in melon carrying the resistance against watermelon mosaic virus, although they contain a common genetic determinant

Authors: Zhen Sun, Yu-Xuan Wu, Ling-Zhi Liu, Yan-Ping Tian, Xiang-Dong Li, Chao Geng

Journal: J Virol

PubMed ID: 38775482

Doi: 10.1128/jvi.00507-24

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Fibroblast growth factor 21 enhances learning and memory performance in mice by regulating hippocampal L-lactate homeostasis

Authors: Jiaojiao Xie, Jiapin Yan, Keru Ji, Yuejun Guo, Sibei Xu, Danjie Shen, Chen Li, Hongchang Gao, Liangcai Zhao

Journal: Int J Biol Macromol

PubMed ID: 38801850

Doi: 10.1016/j.ijbiomac.2024.132667

Products & Services: Molecular Biology Reagents

Fungicidal Activity of New Pyrrolo[2,3-]thiazoles and Their Potential Action on the Tryptophan Metabolic Pathway and Wax Biosynthesis

Authors: Yue Zhang, Jing Li, Hongwei Yang, Kun Li, Haolin Yuan, Ziqiao Xue, Liangfu Tang, Zhijin Fan

Journal: J Agric Food Chem

PubMed ID: 38757490

Doi: 10.1021/acs.jafc.4c00930

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The MuSK agonist antibody protects the neuromuscular junction and extends the lifespan in C9orf72-ALS mice

Authors: Shuangshuang Sun, Yihui Shen, Xu Zhang, Ning Ding, Zhe Xu, Qijie Zhang, Lei Li

Journal: Mol Ther

PubMed ID: 38734896

Doi: 10.1016/j.ymthe.2024.05.016

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Early trajectories of virological and immunological biomarkers and clinical outcomes in patients admitted to hospital for COVID-19: an international, prospective cohort study

Authors: Tomas O Jensen, Thomas A Murray, Greg A Grandits, Mamta K Jain, Birgit Grund, Kathryn Shaw-Saliba, Michael A Matthay, Mahsa Abassi, Magdalena Ardelt, Jason V Baker, Peter Chen, Robin L Dewar, Anna L Goodman, Timothy J Hatlen, Helene C Highbarger, Mark Holodniy, Perrine Lallemand, Sylvain Laverdure, Bradley G Leshnower, David Looney, Charalampos D Moschopoulos, Henry Mugerwa, Daniel D Murray, Eleftherios Mylonakis, Stephanie Nagy-Agren, M Tauseef Rehman, Adam Rupert, Randy Stevens, Stuart Turville, Amy Weintrob, Katherine Wick, Jens Lundgren, Emily R Ko

Journal: Lancet Microbe

PubMed ID: 38815595

Doi: 10.1016/S2666-5247(24)00015-6

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Nanolevel of detection of ascorbic acid using horse-radish peroxidase inhibition assay

Authors: Bijon Kumar Sil, Mohd Raeed Jamiruddin, Md Ahsanul Haq, Nattanit Aekwattanaphol, Prem Ananth K, Limbadri Salendra, Himanshu Paliwal, Pijush Kumar Paul, Wilaiporn Buatong, Teerapol Srichana

Journal: Heliyon

PubMed ID: 38774337

Doi: 10.1016/j.heliyon.2024.e30715

Products & Services: Protein Electrophoresis and Western

Earliest records of the Asian longhorned tick (Acari: Ixodidae) in Staten Island, New York, and subsequent population establishment, with a review of its potential medical and veterinary importance in the United States

Authors: Waheed Bajwa, Ashley Kennedy, Zachary Vincent, Garrett Heck, Shamim Riaj, Zahir Shah, Leonid Tsynman, Cory Casal, Scott Haynes, Hannah Cornman, Andrea Egizi, Ellen Stromdahl, Robyn Nadolny

Journal: J Med Entomol

PubMed ID: 38412407

Doi: 10.1093/jme/tjae019

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Characterisation of novel influenza-derived HLA-B*18:01-restricted epitopes

Authors: Samuel Liwei Leong, Lawton Murdolo, Janesha C Maddumage, Marios Koutsakos, Katherine Kedzierska, Anthony W Purcell, Stephanie Gras, Emma J Grant

Journal: Clin Transl Immunology

PubMed ID: 38737448

Doi: 10.1002/cti2.1509

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A fluorescently-tagged tick kinin neuropeptide triggers peristalsis and labels tick midgut muscles

Authors: Jonathan R Hernandez, Caixing Xiong, Patricia V Pietrantonio

Journal: Sci Rep

PubMed ID: 38740831

Doi: 10.1038/s41598-024-61570-w

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Fluorinated hydroxyapatite conditions a favorable osteo-immune microenvironment via triggering metabolic shift from glycolysis to oxidative phosphorylation

Authors: Kaidi Chen, Seongmin Ha, Leyao Xu, Chengwu Liu, Yuanxiang Liu, Xiayi Wu, Zhipeng Li, Shiyu Wu, Bo Yang, Zhuofan Chen

Journal: J Transl Med

PubMed ID: 38720345

Doi: 10.1186/s12967-024-05261-0

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Evolution of a novel adrenal cell type that promotes parental care

Authors: Natalie Niepoth, Jennifer R Merritt, Michelle Uminski, Emily Lei, Victoria S Esquibies, Ina B Bando, Kimberly Hernandez, Christoph Gebhardt, Sarah A Wacker, Stefano Lutzu, Asmita Poudel, Kiran K Soma, Stephanie Rudolph, Andres Bendesky

Journal: Nature

PubMed ID: 38750354

Doi: 10.1038/s41586-024-07423-y

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Cardiac function is regulated by the sodium-dependent inhibition of the sodium-calcium exchanger NCX1

Authors: Kyle Scranton, Scott John, Marina Angelini, Federica Steccanella, Soban Umar, Rui Zhang, Joshua I Goldhaber, Riccardo Olcese, Michela Ottolia

Journal: Nat Commun

PubMed ID: 38714663

Doi: 10.1038/s41467-024-47850-z

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Nonclinical Evaluation of Single-Mutant Asparaginases Obtained by Double-Mutant Deconvolution: Improving Toxicological, Immune and Inflammatory Responses

Authors: Grace Ruiz-Lara, Tales A Costa-Silva, Jorge Javier Muso-Cachumba, Johanna Cevallos Espinel, Marina Gabriel Fontes, Mitla Garcia-Maya, Khondaker Miraz Rahman, Carlota de Oliveira Rangel-Yagui, Gisele Monteiro

Journal: Int J Mol Sci

PubMed ID: 38892196

Doi: 10.3390/ijms25116008

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Podocyte Pathogenic Bone Morphogenetic Protein-2 Pathway and Immune Cell Behaviors in Primary Membranous Nephropathy

Authors: Anxiang Cai, Yiwei Meng, Hang Zhou, Hong Cai, Xinghua Shao, Qin Wang, Yao Xu, Yin Zhou, Wenyan Zhou, Luonan Chen, Shan Mou

Journal: Adv Sci (Weinh)

PubMed ID: 38785168

Doi: 10.1002/advs.202404151

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Oriented immobilization of antibodies through peptide ligands for ultrasensitive detection of gastrin 17 in human serum via lateral flow immunoassay

Authors: Xintong Li , Jiale Cui , Jin Li , Yulian Wang , Guoqing Shi

Journal: Microchemical Journal

Doi: j.microc.2024.110819

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Staphylococcal peroxidase inhibitor (SPIN): Residue-level investigation of the helical bundle domain

Authors: Soheila Fatehi, Timothy J Herdendorf, Nicoleta T Ploscariu, Brian V Geisbrecht

Journal: Arch Biochem Biophys

PubMed ID: 38705227

Doi: 10.1016/j.abb.2024.110023

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Establishment of an ELISA Based on a Recombinant Antigenic Protein Containing Multiple Prominent Epitopes for Detection of African Swine Fever Virus Antibodies

Authors: Dossêh Jean Apôtre Afayibo, Zhonghui Zhang, Hualin Sun, Jingsheng Fu, Yaru Zhao, Tharheer Oluwashola Amuda, Mengli Wu, Junzheng Du, Guiquan Guan, Qingli Niu, Jifei Yang, Hong Yin

Journal: Microorganisms

PubMed ID: 38792774

Doi: 10.3390/microorganisms12050943

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Preparation and epitope analysis of monoclonal antibodies against African swine fever virus DP96R protein

Authors: Chao Li, Xuan-Ying Si, Xiao-Ge Wang, Zhi-Wei Yan, Hao-Yu Hou, Long-Qi You, Yin-Long Chen, Ang-Ke Zhang, Na Wang, Ai-Jun Sun, Yong-Kun Du, Gai-Ping Zhang

Journal: BMC Vet Res

PubMed ID: 38734611

Doi: 10.1186/s12917-024-04043-6

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Ser/Leu-swapped cell-free translation system constructed with natural/in vitro transcribed-hybrid tRNA set

Authors: Tomoshige Fujino, Ryogo Sonoda, Taito Higashinagata, Emi Mishiro-Sato, Keiko Kano, Hiroshi Murakami

Journal: Nat Commun

PubMed ID: 38755134

Doi: 10.1038/s41467-024-48056-z

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A novel mouse model for investigating α-synuclein aggregates in oligodendrocytes: implications for the glial cytoplasmic inclusions in multiple system atrophy

Authors: Tomoyuki Ishimoto, Miki Oono, Seiji Kaji, Takashi Ayaki, Katsuya Nishida, Itaru Funakawa, Takakuni Maki, Shu-Ichi Matsuzawa, Ryosuke Takahashi, Hodaka Yamakado

Journal: Mol Brain

PubMed ID: 38790036

Doi: 10.1186/s13041-024-01104-7

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Tracking single-cell evolution using clock-like chromatin accessibility loci

Authors: Yu Xiao, Wan Jin, Lingao Ju, Jie Fu, Gang Wang, Mengxue Yu, Fangjin Chen, Kaiyu Qian, Xinghuan Wang & Yi Zhang

Journal: Nature Biotechnol

PubMed ID: 38724668

Doi: 10.1038/s41587-024-02241-z

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