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Genetic fusion of CCL11 to antigens enhances antigenicity in nucleic acid vaccines and eradicates tumor mass through optimizing T-cell response

Authors: Hailong Qi, Zhongjie Sun, Tianle Gao, Yanling Yao, Yu Wang, Weiwei Li, Xudong Wang, Xiaofang Wang, Defang Liu, Jian-Dong Jiang

Journal: Mol Cancer

PubMed ID: 38459592

Doi: 10.1186/s12943-024-01958-4

Products & Services: Protein and Antibody Isolation

MicroRNA-223-3p downregulates the inflammatory response in preeclampsia placenta via targeting NLRP3

Authors: Xueqiong Liu, Zhiyue Li, Dan Lu

Journal: BMC Pregnancy Childbirth

PubMed ID: 38448875

Doi: 10.1186/s12884-024-06371-9

Products & Services: Gene Synthesis

Bioengineered Hydrogels Recapitulate Fibroblast Heterogeneity in Cancer

Authors: Nicholas Ching Wei Ho, Josephine Yu Yan Yap, Zixuan Zhao, Yunyun Wang, Kanishka Fernando, Constance H Li, Xue Lin Kwang, Hong Sheng Quah, Camille Arcinas, N Gopalakrishna Iyer, Eliza Li Shan Fong

Journal: Adv Sci (Weinh)

PubMed ID: 38493497

Doi: 10.1002/advs.202307129

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Bactericera cockerelli Picorna-like Virus and Three New Viruses Found Circulating in Populations of Potato/Tomato Psyllids ()

Authors: Jennifer Dahan, Gardenia E Orellana, Kaleigh B Wald, Erik J Wenninger, W Rodney Cooper, Alexander V Karasev

Journal: Viruses

PubMed ID: 38543780

Doi: 10.3390/v16030415

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Absence of specific autoantibodies in patients with narcolepsy type 1 as indicated by an unbiased random peptide-displayed phage screening

Authors: Thi-Tuyet Trinh Tran, Thi-Hong Nhung Nguyen, Yves Dauvilliers, Roland Liblau, Xuan-Hung Nguyen

Journal: PLoS ONE

PubMed ID: 38442093

Doi: 10.1371/journal.pone.0297625

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A new trivalent recombinant protein for type 2 diabetes mellitus with oral delivery potential: design, expression, and experimental validation

Authors: Maryam Ehsasatvatan, Bahram Baghban Kohnehrouz

Journal: J Biomol Struct Dyn

PubMed ID: 38468545

Doi: 10.1080/07391102.2024.2329290

Products & Services: Molecular Biology Reagents

Rational Design of Key Enzymes to Efficiently Synthesize Phycocyanobilin in

Authors: Ziwei Wang, Jingwen Zhou, Jianghua Li, Guocheng Du, Jian Chen, Xinrui Zhao

Journal: Biomolecules

PubMed ID: 38540721

Doi: 10.3390/biom14030301

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A Synergistic Lipid Nanoparticle Encapsulating mRNA Shingles Vaccine Induces Potent Immune Responses and Protects Guinea Pigs from Viral Challenges

Authors: Xingdi Cheng 1 2, Sujia Liu 3, Jing Sun 4, Lin Liu 3, Xinghuan Ma 3, Jingjiao Li 1 2, Bangda Fan 3, Chen Yang 1 2, Yuanyuan Zhao 1 2, Shuai Liu 1, Yixing Wen 1 2, Wei Li 1 2, Simin Sun 1, Shiwei Mi 1 2, Haonan Huo 1 2, Lei Miao 5, Hao Pan 6, Xiaolan Cui 4, Jiaqi Lin 3, Xueguang Lu 1 2

Journal: Adv Mater

PubMed ID: 38145557

Doi: 10.1002/adma.20231088

Products & Services: Plasmid DNA Preparation Custom mRNA synthesis

LysSYL: a broad-spectrum phage endolysin targeting Staphylococcus species and eradicating S aureus biofilms

Authors: He Liu, Xuemei Wei, Zhefen Wang, Xiaonan Huang, Mengyang Li, Zhen Hu, Kexin Zhang, Qiwen Hu, Huagang Peng, Weilong Shang, Yi Yang, Yuting Wang, Shuguang Lu, Xiancai Rao

Journal: Microb Cell Fact

PubMed ID: 38528536

Doi: 10.1186/s12934-024-02359-4

Products & Services: Molecular Biology Reagents

Self-adaptive pyroptosis-responsive nanoliposomes block pyroptosis in autoimmune inflammatory diseases

Authors: Kaiwang Xu, Huang Yang, Jinghua Fang, Kaijie Qiu, Haotian Shen, Guanrui Huang, Qiangqiang Zheng, Canlong Wang, Tengjing Xu, Xinning Yu, Jiajie Wang, Yunting Lin, Jiacheng Dai, Yuting Zhong, Hongyun Song, Sunan Zhu, Siheng Wang, Zhuxing Zhou, Guang Yang, Zhengwei Mao, Zongyou Pan, Xuesong Dai

Journal: Bioactive Materials

PubMed ID: 38496034

Doi: 10.1016/j.bioactmat.2024.02.022

Products & Services: Bacterial Expression Mammalian Expression

Interferon-γ in the tumor microenvironment promotes the expression of B7H4 in colorectal cancer cells, thereby inhibiting cytotoxic T cells

Authors: Zhi-Liang Jing, Guang-Long Liu, Na Zhou, Dong-Yan Xu, Na Feng, Yan Lei, Li-Li Ma, Min-Shan Tang, Gui-Hui Tong, Na Tang, Yong-Jian Deng

Journal: Nature

PubMed ID: 38480774

Doi: 10.1038/s41598-024-56681-3

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Molecular basis for substrate transport of Mycobacterium tuberculosis ABC importer DppABCD

Authors: Tianyu Hu, Xiaolin Yang, Yuanchen Zhu, Fengjiang Liu, Xiuna Yang, Zhiqi Xiong, Jingxi Liang, Zhenli Lin, Yuting Ran, Luke W Guddat, Zihe Rao, Bing Zhang

Journal: SCIENCE ADVANCES

PubMed ID: 38507491

Doi: 10.1126/sciadv.adk8521

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MIWI N-terminal arginines orchestrate generation of functional pachytene piRNAs and spermiogenesis

Authors: Nicholas Vrettos, Jan Oppelt, Ansgar Zoch, Paraskevi Sgourdou, Haruka Yoshida, Brian Song, Ryan Fink, Dónal O'Carroll, Zissimos Mourelatos 1

Journal: Nucleic Acids Research

PubMed ID: 38520410

Doi: 10.1093/nar/gkae193

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An intein-based biosensor to measure protein stability in vivo

Authors: Ahyun Son, John S Smetana, Scott Horowitz , Christopher W Lennon

Journal: Protein Sci

PubMed ID: 38380775

Doi: 10.1002/pro.4925

Products & Services: Gene Synthesis

Structural basis of U12-type intron engagement by the fully assembled human minor spliceosome

Authors: Rui Bai, Meng Yuan, Pu Zhang, Ting Luo, Yigong Shi, Ruixue Wan

Journal: Science

PubMed ID: 38484052

Doi: 10.1126/science.adn7272

Products & Services: Gene Synthesis

G-quadruplexes control hepatitis B virus replication by promoting cccDNA transcription and phase separation in hepatocytes

Authors: Guillaume Giraud, Mélanie Rodà, Pélagie Huchon, Maud Michelet, Sarah Maadadi, Daniel Jutzi, Roland Montserret, Marc-David Ruepp, Romain Parent, Christophe Combet, Fabien Zoulim, Barbara Testoni

Journal: Nucleic Acids Res

PubMed ID: 38113270

Doi: 10.1093/nar/gkad1200

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Identification and expression analysis of family gene in L

Authors: Jiao Xu, Lingyang Kong, Weichao Ren, Zhen Wang, Lili Tang, Wei Wu, Xiubo Liu, Wei Ma, Shuquan Zhang

Journal: Heliyon

PubMed ID: 38545150

Doi: 10.1016/j.heliyon.2024.e27817

Products & Services: Protein and Antibody Isolation

Correction to "Subtilisin 3 production from Microsporum canis is independent of keratin substrate availability"

Authors:

Journal: J Basic Microbiol

PubMed ID: 38533930

Doi: 10.1002/jobm.202470023

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Identification of the grass carp interleukin-23 receptor and its proinflammatory role in intestinal inflammation

Authors: Panpan Han, Jian Tang, Xufang Xu, Pengkun Meng, Kang Wu, Bingyao Sun, Xuehong Song

Journal: Int J Biol Macromol

PubMed ID: 38521334

Doi: 10.1016/j.ijbiomac.2024.130946

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A long-term cohort study: the immune evasion and decreasing neutralization dominated the SARS-CoV-2 breakthrough infection

Authors: Qianyun Liu, Meihua Jin, Fanghua Mei, Hui Fan, Mengxue Gu, Yuzhen Zhang, Shengnan Qian, Xue Tan, Lei Ji, Zhen Zhang, Guozhong Chen, Huan Yan, Yu Chen, Ke Lan, Qing Geng, Kun Cai, Li Zhou

Journal: Front Cell Infect Microbiol

PubMed ID: 38572316

Doi: 10.3389/fcimb.2024.1381877

Products & Services: Protein and Antibody Isolation

Binding and Activation of LRP1-Dependent Cell Signaling in Schwann Cells Using a Peptide Derived from the Hemopexin Domain of MMP-9

Authors: John H Kim, Aashish Shivkumar, Masaki Norimoto, Sascha Castro Lingl, Christian Seitz, Rommie E Amaro, Steve L Gonias, Jerry Yang, Wendy M Campana

Journal: Biochemistry

PubMed ID: 38450612

Doi: 10.1021/acs.biochem.3c00705

Products & Services: Molecular Biology Reagents

Taraxasterol enhanced bladder cancer cells radiosensitivity via inhibiting the COX-2/PGE2/JAK2/STAT3/MMP pathway

Authors: Quanxin Wang, Ruiqi Zhang, Yijun He, Guangmin Mao, Zhaolu Kong

Journal: Int J Radiat Biol

PubMed ID: 38442139

Doi: 10.1080/09553002.2024.2324475

Products & Services: DNA Sequencing

Occlusal force orchestrates alveolar bone homeostasis via Piezo1 in female mice

Authors: Yiling Yang, Qinggang Dai, Xin Gao, Yanfei Zhu, Mi Ri Chung, Anting Jin, Yuanqi Liu, Xijun Wang, Xiangru Huang, Siyuan Sun, Hongyuan Xu, Jingyi Liu, Lingyong Jiang

Journal: J Bone Miner Res

PubMed ID: 38477783

Doi: 10.1093/jbmr/zjae032

Products & Services: Protein Electrophoresis and Western

Unveiling a Shield of Hope: A Novel Multiepitope-Based Immunogen for Cross-Serotype Cellular Defense against Dengue Virus

Authors: Nilanshu Manocha, Daphné Laubreton, Xavier Robert, Jacqueline Marvel, Virginie Gueguen-Chaignon, Patrice Gouet, Prashant Kumar, Madhu Khanna

Journal: Vaccines (Basel)

PubMed ID: 38543950

Doi: 10.3390/vaccines12030316

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Nintedanib downregulates the profibrotic M2 phenotype in cultured monocyte-derived macrophages obtained from systemic sclerosis patients affected by interstitial lung disease

Authors: Stefano Soldano, Vanessa Smith, Paola Montagna, Emanuele Gotelli, Rosanna Campitiello, Carmen Pizzorni, Sabrina Paolino, Alberto Sulli, Andrea Cere, Maurizio Cutolo

Journal: Arthritis Res Ther

PubMed ID: 38509595

Doi: 10.1186/s13075-024-03308-7

Products & Services: Protein and Antibody Isolation

Zoledronic Acid Accelerates ER Stress-Mediated Inflammation by Increasing PDE4B Expression in Bisphosphonate-Related Osteonecrosis of the Jaw

Authors: Qu Xz, Sun Zq, Liu L, Ong Hs

Journal: Appl Biochem Biotechnol

PubMed ID: 38523176

Doi: 10.1007/s12010-024-04859-w

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Supra-biological performance of immobilized enzymes enabled by chaperone-like specific non-covalent interactions

Authors: Héctor Sánchez-Morán, Joel L Kaar, Daniel K Schwartz

Journal: Nat Commun

PubMed ID: 38485940

Doi: 10.1038/s41467-024-46719-5

Products & Services: Molecular Biology Reagents

Structural determination and kinetic analysis of the transketolase from Vibrio vulnificus reveal unexpected cooperative behavior

Authors: Rainier-Numa Georges, Lionel Ballut, Guillaume Octobre, Arnaud Comte, Laurence Hecquet, Franck Charmantray, Bastien Doumèche

Journal: Protein Sci

PubMed ID: 38145310

Doi: 10.1002/pro.4884

Products & Services: Molecular Biology Reagents

Tight junction protein cingulin variant is associated with cancer susceptibility by overexpressed IQGAP1 and Rac1-dependent epithelial-mesenchymal transition

Authors: Yi-Ting Huang, Ya-Ting Hsu, Pei-Ying Wu, Yu-Min Yeh, Peng-Chan Lin, Keng-Fu Hsu, Meng-Ru Shen

Journal: J Exp Clin Cancer Res

PubMed ID: 38424547

Doi: 10.1186/s13046-024-02987-z

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Therapeutic targeting nudix hydrolase 1 creates a MYC-driven metabolic vulnerability

Authors: Minhui Ye, Yingzhe Fang, Lu Chen, Zemin Song, Qing Bao, Fei Wang, Hao Huang, Jin Xu, Ziwen Wang, Ruijing Xiao, Meng Han, Song Gao, Hudan Liu, Baishan Jiang, Guoliang Qing

Journal: Nat Commun

PubMed ID: 38493213

Doi: 10.1038/s41467-024-46572-6

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Effective Gene Therapy for Metachromatic Leukodystrophy Achieved with Minimal Lentiviral Genomic Integrations

Authors: Lucas Tricoli, Sunetra Sase, Julia Hacker, Vi Pham, Sidney Smith, Maxwell Chappell, Laura Breda, Stephanie Hurwitz, Naoto Tanaka, Carlo Castruccio Castracani, Amaliris Guerra, Zhongqi Hou, Lars Schlotawa, Karthikeyan Radhakrishnan, Peter Kurre, Rebecca Ahrens-Nicklas, Laura Adang, Adeline Vanderver, Stefano Rivella

Journal: biorxiv

PubMed ID: 38559013

Doi: 10.1101/2024.03.14.584404

Products & Services: Molecular Biology Reagents

Diverse INOSITOL PHOSPHORYLCERAMIDE SYNTHASE mutant alleles of Physcomitrium patens offer new insight into complex sphingolipid metabolism

Authors: Tegan M Haslam, Cornelia Herrfurth, Ivo Feussner

Journal: New Phytol

PubMed ID: 38523559

Doi: 10.1111/nph.19667

Products & Services: Gene Synthesis

Aging-induced tRNAGlu-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization

Authors: Dingfeng Li, Xinyi Gao, Xiaolin Ma, Ming Wang, Chuandong Cheng, Tian Xue, Feng Gao, Yong Shen, Juan Zhang, Qiang Liu

Journal: Cell Metab

PubMed ID: 38458203

Doi: 10.1016/j.cmet.2024.02.011.

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A SARS-CoV-2 Nanobody Displayed on the Surface of Human Ferritin with High Neutralization Activity

Authors: Wenrong Zhang, Haining Wang, Tong Wu, Xintao Gao, Yuting Shang, Zhifang Zhang, Xingjian Liu, Yinü Li

Journal: International journal of nanomedicine

PubMed ID: 38476285

Doi: 10.2147/IJN.S450829

Products & Services: Molecular Biology Reagents

A conserved protein tyrosine phosphatase, PTPN-22, functions in diverse developmental processes in

Authors: Shaonil Binti, Adison G Linder, Philip T Edeen, David S Fay

Journal: biorxiv

PubMed ID: 38559252

Doi: 10.1101/2024.03.12.584557

Upregulation of CIRP by its agonist prevents the development of heart failure in myocardial infarction rats

Authors: Jingjing Zhang, Tao Liu, Yanzhao Wei, Jianye Peng, Gaofeng Zeng, Peng Zhong

Journal: BMC Cardiovasc Disord

PubMed ID: 38539067

Doi: 10.1186/s12872-024-03852-9

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Post-therapeutic cure criterion in chronic Chagas disease using Trypanosoma cruzi chimeric proteins

Authors: Tycha Bianca Sabaini Pavan, Leonardo Maia Leony, Wayner Vieira de Souza, Emily Ferreira Santos, Ramona Tavares Daltro, Natalia Erdens Maron Freitas, Larissa Carvalho Medrado Vasconcelos, Fernanda Lopes Habib, Angelo Antonio Oliveira Silva, Paola Alejandra Fiorani Celedon, Daniel Dias Sampaio, Nilson Ivo Tonin Zanchin, Silvia Andrea Longhi, Fred Luciano Neves Santos

Journal: Folia Parasitol (Praha)

PubMed ID: 38526232

Doi: 10.14411/fp.2024.004

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Extracellular vesicles promote proliferation in an animal model of regeneration

Authors: Priscilla N Avalos, Lily L Wong, David J Forsthoefel

Journal: biorxiv

PubMed ID: 38712279

Doi: 10.1101/2024.03.22.586206

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Tuning Molecular Motion Enhances Intrinsic Fluorescence in Peptide Amphiphile Nanofibers

Authors: Natchayaporn Sindhurattavej, Shreya Jampana, Mai Phuong Pham, Leonardo C Romero, Anna Grace Rogers, Griffin A Stevens, Whitney C Fowler

Journal: Biomacromolecules

PubMed ID: 38508219

Doi: 10.1021/acs.biomac.4c00050

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Comparison of Neutralizing Activity between Vaccinated and Unvaccinated Hospitalized COVID-19 Patients Infected with Delta, Omicron BA1, or Omicron BA2 Variant

Authors: Keun Ju Kim, Seo-Jin Park, Seung Gyu Yun, Sang Wook Kim, Myung-Hyun Nam, Eun Kyong Shin, Eun-Ah Chang, Dae Won Park, Chang Kyu Lee, Young Kyung Yoon, Yunjung Cho

Journal: Microorganisms

PubMed ID: 38543560

Doi: 10.3390/microorganisms12030509

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Long-term monitoring of ultratrace nucleic acids using tetrahedral nanostructure-based NgAgo on wearable microneedles

Authors: Bin Yang, Haonan Wang, Jilie Kong, Xueen Fang

Journal: Nat Commun

PubMed ID: 38431675

Doi: 10.1038/s41467-024-46215-w

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Reduction in Interferon-Stimulated Genes Contributes to High-Yield Production of Influenza Virus in Suspension MDCK Cells

Authors: Qi Wang, Jian Luo, Beibei Li, Qian Ye, Wenting Xu, Feixia Gao, Linting Zhou, Wenyue Lu, Wen-Song Tan, Xiuling Li

Journal: Vaccines

PubMed ID: 38543921

Doi: 10.3390/vaccines12030287

Products & Services: Protein and Antibody Isolation

Identification of CEP peptides encoded by the tobacco (Nicotiana tabacum) genome and characterization of their roles in osmotic and salt stress responses

Authors: Xiaolu Pan, Zhichao Deng, Rongrong Wu, Yalun Yang, Sayed Abdul Akher, Wei Li, Zenglin Zhang, Yongfeng Guo

Journal: Plant Physiol Biochem

PubMed ID: 38518396

Doi: 10.1016/j.plaphy.2024.108525

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Complex -glycans are important for interspecies transmission of H7 influenza A viruses

Authors: Cindy M Spruit, Diana I Palme, Tiehai Li, María Ríos Carrasco, Alba Gabarroca García, Igor R Sweet, Maryna Kuryshko, Joshua C L Maliepaard, Karli R Reiding, David Scheibner, Geert-Jan Boons, Elsayed M Abdelwhab, Robert P de Vries

Journal: J Virol

PubMed ID: 38470143

Doi: 10.1128/jvi.01941-23

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PLD3 and PLD4 synthesize -BMP, a key phospholipid enabling lipid degradation in lysosomes

Authors: Shubham Singh, Ulrich Dransfeld, Yohannes Ambaw, Joshua Lopez-Scarim, Robert V Farese, Tobias C Walther

Journal: biorxiv

PubMed ID: 38562702

Doi: 10.1101/2024.03.21.586175

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Vesicular translocation of PARP-1 to cytoplasm causes ADP-ribosylation and disassembly of vimentin filaments during microglia activation induced by LPS

Authors: Ruiqi Chen, Lirui Xie, Yang Fan, Xiangmei Hua, Chang Y Chung

Journal: Front Cell Neurosci

PubMed ID: 38590714

Doi: 10.3389/fncel.2024.1363154

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Derivation of a novel antimicrobial peptide from the Red Sea Brine Pools modified to enhance its anticancer activity against U2OS cells

Authors: Mona Elradi, Ahmed I Ahmed, Ahmed M Saleh, Khaled M A Abdel-Raouf, Lina Berika, Yara Daoud, Asma Amleh

Journal: BMC Biotechnol

PubMed ID: 38491556

Doi: 10.1186/s12896-024-00835-8

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High temperature delays and low temperature accelerates evolution of a new protein phenotype

Authors: Jia Zheng, Ning Guo, Yuxiang Huang, Xiang Guo, Andreas Wagner

Journal: Nat Commun

PubMed ID: 38553445

Doi: 10.1038/s41467-024-46332-6

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Variation of gene expression of fatty acid acyl CoA reductase associated with wax secretion of a scale insect, Ericerus pela, and identification of its regulation factors through the accessible chromatin analyses and yeast one-hybrid

Authors: Zuoyi Fu, Yuanchong Shi, Shuhui Yu, Qiuyu Zhao, Haifeng Mo, Pu Yang

Journal: Arch Insect Biochem Physiol

PubMed ID: 38500444

Doi: 10.1002/arch.22101

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Mutagenesis and functional analysis of the varicella-zoster virus portal protein

Authors: Melissa A Visalli, Dakota J Nale Lovett, Ellyn M Kornfeind, Haley Herrington, Yi Tian Xiao, Daniel Lee, Patience Plair, S Garrett Wilder, Bret K Garza, Ashton Young, Robert J Visalli

Journal: J Virol

PubMed ID: 38517165

Doi: 10.1128/jvi.00603-23

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