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Kinetic and catalytic features of N-myristoyltransferases

Authors: Frédéric Rivière , Paul Monassa , Carmela Giglione , Thierry Meinnel

Journal: Methods Enzymol .

PubMed ID: 37230588

Doi: 10.1016/bs.mie.2023.02.018

Products & Services: Peptide Synthesis

A structure-based designed small molecule depletes hRpn13Pru and a select group of KEN box proteins

Authors: Xiuxiu Lu, Monika Chandravanshi, Venkata R Sabbasani, Snehal Gaikwad, V Keith Hughitt, Nana Gyabaah-Kessie, Bradley T Scroggins, Sudipto Das, Wazo Myint, Michelle E Clapp, Charles D Schwieters, Marzena A Dyba, Derek L Bolhuis, Janusz W Koscielniak, Thorkell Andresson, Michael J Emanuele, Nicholas G Brown, Hiroshi Matsuo, Raj Chari, Deborah E Citrin, Beverly A Mock, Rolf E Swenson, Kylie J Walters

Journal: Nature

PubMed ID: 38509117

Doi: 10.1038/s41467-024-46644-7

Products & Services: Plasmid DNA Preparation

Humanin variant P3S is associated with longevity in APOE4 carriers and resists APOE4-induced brain pathology

Authors: Brendan Miller, Su-Jeong Kim, Kevin Cao, Hemal H Mehta, Neehar Thumaty, Hiroshi Kumagai, Tomomitsu Iida, Cassandra McGill, Christian J Pike, Kamila Nurmakova, Zachary A Levine, Patrick M Sullivan, Kelvin Yen, Nilüfer Ertekin-Taner, Gil Atzmon, Nir Barzilai, Pinchas Cohen

Journal: Cell

PubMed ID: 38520065

Doi: 10.1111/acel.14153

Products & Services: Gene Synthesis

ARGLU1 enhances promoter-proximal pausing of RNA polymerase II and stimulates DNA damage repair

Authors: Scott Bachus, Nikolas Akkerman, Lauren Fulham, Drayson Graves, Rafe Helwer, Jordan Rempel, Peter Pelka

Journal: Nucleic Acids Research

PubMed ID: 38520408

Doi: 10.1093/nar/gkae208

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DNA fragility at topologically associated domain boundaries is promoted by alternative DNA secondary structure and topoisomerase II activity

Authors: Heather M Raimer Young, Pei-Chi Hou, Anna R Bartosik, Naomi D Atkin, Lixin Wang, Zhenjia Wang, Aakrosh Ratan, Chongzhi Zang, Yuh-Hwa Wang

Journal: Nucleic Acids Research

PubMed ID: 38452213

Doi: 10.1093/nar/gkae164

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MiR-326 sponges TET2 triggering imbalance of Th17/Treg differentiation to exacerbate pyroptosis of hepatocytes in concanavalin A-induced autoimmune hepatitis

Authors: Genglin Zhang, Sensen Wu, Guangtao Xia

Journal: Hepatology

PubMed ID: 38043702

Doi: 10.1016/j.aohep.2023.101183

Products & Services: Codon Optimization

Novel Fragment Inhibitors of PYCR1 from Docking-Guided X-ray Crystallography

Authors: Kaylen R Meeks, Juan Ji , Mykola V Protopopov , Olga O Tarkhanova , Yurii S Moroz , John J Tanner

Journal: J Chem Inf Model

PubMed ID: 38411104

Doi: 10.1021/acs.jcim.3c01879

Products & Services: Molecular Biology Reagents

Highly sensitive spatial transcriptomics using FISHnCHIPs of multiple co-expressed genes

Authors: Xinrui Zhou , Wan Yi Seow, Norbert Ha, Teh How Cheng, Lingfan Jiang, Jeeranan Boonruangkan, Jolene Jie Lin Goh, Shyam Prabhakar, Nigel Chou, Kok Hao Chen Affiliations expand

Journal: Nat Commun

PubMed ID: 38491027

Doi: s41467-024-46669-y

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Structural analysis of phosphoribosyltransferase-mediated cell wall precursor synthesis in Mycobacterium tuberculosis

Authors: Shan Gao, Fangyu Wu, Sudagar S Gurcha, Sarah M Batt, Gurdyal S Besra, Zihe Rao, Lu Zhang

Journal: Nature

PubMed ID: 38491273

Doi: 10.1038/s41564-024-01643-8

Products & Services: Protein and Antibody Isolation

The rapid proximity labeling system PhastID identifies ATP6AP1 as an unconventional GEF for Rheb

Authors: Ran Feng, Feng Liu, Ruofei Li, Zhifen Zhou, Zhuoheng Lin, Song Lin, Shengcheng Deng, Yingying Li, Baoting Nong, Ying Xia, Zhiyi Li, Xiaoqin Zhong, Shuhan Yang, Gang Wan, Wenbin Ma, Su Wu, Zhou Songyang

Journal: Cell Research

PubMed ID: 38448650

Doi: 10.1038/s41422-024-00938-z

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Persistent immune imprinting occurs after vaccination with the COVID-19 XBB.1.5 mRNA booster in humans

Authors: M Alejandra Tortorici, Amin Addetia, Albert J Seo, Jack Brown, Kaiti Sprouse, Jenni Logue, Erica Clark, Nicholas Franko, Helen Chu, David Veesler

Journal: Immunity

PubMed ID: 38490197

Doi: 10.1016/j.immuni.2024.02.016

Products & Services: Plasmid DNA Preparation

Specific protein-RNA interactions are mostly preserved in biomolecular condensates

Authors: Tebbe de Vries, Mihajlo Novakovic, Yinan Ni, Izabela Smok, Clara Inghelram, Maria Bikaki, Chris P Sarnowski, Yaning Han, Leonidas Emmanouilidis, Giacomo Padroni, Alexander Leitner, Frédéric H-T Allain

Journal: SCIENCE ADVANCES

PubMed ID: 38446881

Doi: 10.1126/sciadv.adm7435

Products & Services: PCR Cloning and Subcloning

A uniquely efficacious type of CFTR corrector with complementary mode of action

Authors: Valentina Marchesin, Lucile Monnier, Peter Blattmann, Florent Chevillard, Christine Kuntz, Camille Forny, Judith Kamper, Rolf Studer, Alexandre Bossu, Eric A Ertel, Oliver Nayler, Christine Brotschi, Jodi T Williams, John Gatfield

Journal: SCIENCE ADVANCES

PubMed ID: 38427726

Doi: 10.1126/sciadv.adk1814

Products & Services: PCR Cloning and Subcloning

FUS reads histone H3K36me3 to regulate alternative polyadenylation

Authors: Junqi Jia, Haonan Fan, Xinyi Wan, Yuan Fang, Zhuoning Li, Yin Tang, Yanjun Zhang, Jun Huang, Dong Fang

Journal: Nucleic Acids Research

PubMed ID: 38499486

Doi: 10.1093/nar/gkae184

Products & Services: Protein and Antibody Isolation

An optimised protocol for the expression and purification of adenovirus core protein VII

Authors: Ajani Athukorala, Karla J Helbig, Brian P McSharry, Jade K Forwood, Subir Sarker

Journal: J Virol Methods

PubMed ID: 38432358

Doi: 10.1016/j.jviromet.2024.114907

Products & Services: Molecular Biology Reagents

Exploring functional genes' correlation with ()-equol concentration and new daidzein racemase identification

Authors: Yun-Fei Hu, Shu Luo, Sheng-Qi Wang, Ke-Xin Chen, Wei-Xuan Zhong, Bai-Yuan Li, Lin-Yan Cao, Hua-Hai Chen, Ye-Shi Yin

Journal: Appl Environ Microbiol

PubMed ID: 38501861

Doi: 10.1128/aem.00007-24

Products & Services: Molecular Biology Reagents

Quantification of SARS-CoV-2 monoclonal IgG mass fraction by isotope dilution mass spectrometry

Authors: G Martos, M Bedu, R D Josephs, S Westwood, R I Wielgosz

Journal: Anal Bioanal Chem

PubMed ID: 38427100

Doi: 10.1007/s00216-024-05205-z

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Morusin Alleviates Aortic Valve Calcification by Inhibiting Valve Interstitial Cell Senescence Through Ccnd1/Trim25/Nrf2 Axis

Authors: Zongtao Liu, Kan Wang, Chen Jiang, Yuqi Chen, Fayuan Liu, Minghui Xie, Wai Yen Yim, Dingyi Yao, Xingyu Qian, Shiqi Chen, Jiawei Shi, Kang Xu, Yixuan Wang, Nianguo Dong

Journal: Adv Sci (Weinh)

PubMed ID: 38502885

Doi: 10.1002/advs.202307319

Products & Services: Gene Synthesis

Association mechanism between Arabidopsis immune coreceptor BAK1 and Pseudomonas syringae effector HopF2

Authors: Rui Han, Tongtong Zhu, Lili Zhou, Meiqing Chen, Dongli Wang, Junfeng Liu

Journal: Biochem Biophys Res Commun

PubMed ID: 38579538

Doi: 10.1016/j.bbrc.2024.149871

Products & Services: Protein and Antibody Isolation

Dependency on host vitamin B12 has shaped Mycobacterium tuberculosis Complex evolution

Authors: Elena Campos-Pardos, Santiago Uranga, Ana Picó, Ana Belén Gómez, Jesús Gonzalo-Asensio

Journal: Nat Commun

PubMed ID: 38461302

Doi: 10.1038/s41467-024-46449-8

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Engineering APOBEC3A deaminase for highly accurate and efficient base editing

Authors: Lei Yang, Yanan Huo, Man Wang, Dan Zhang, Tianai Zhang, Hao Wu, Xichen Rao, Haowei Meng, Shuming Yin, Jiale Mei, Dexin Zhang, Xi Chen, Jia Lv, Meizhen Liu, Yiyun Cheng, Yuting Guan, Bo Feng, Gaojie Song, Chengqi Yi, Mingyao Liu, Fanyi Zeng, Liren Wang, Dali Li

Journal: Nat Chem Biol

PubMed ID: 38553609

Doi: 10.1038/s41589-024-01595-4

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Spatial enhancer activation influences inhibitory neuron identity during mouse embryonic development

Authors: Elena Dvoretskova, May C Ho, Volker Kittke, Florian Neuhaus, Ilaria Vitali, Daniel D Lam, Irene Delgado, Chao Feng, Miguel Torres, Juliane Winkelmann, Christian Mayer

Journal: Nat Neurosci

PubMed ID: 38528203

Doi: 10.1038/s41593-024-01611-9

Products & Services: Molecular Biology Reagents

The Evolution and Application of a Novel DNA Aptamer Targeting Bone Morphogenetic Protein 2 for Bone Regeneration

Authors: Mengping Liu, Andrew B Kinghorn, Lin Wang, Soubhagya K Bhuyan, Simon Chi-Chin Shiu, Julian A Tanner

Journal: Molecules

PubMed ID: 38542880

Doi: 10.3390/molecules29061243

Products & Services: Gene Synthesis

Modulation of Primary and Secondary Processes in Tau Fibril Formation by Salt-Induced Dynamics

Authors: Arshad Abdul Vahid, Muhammed Shafeek Oliyantakath Hassan, Allwin Ebenezer Sahayaraj, Ann Teres Babu, Safwa T Kizhakkeduth, Vinesh Vijayan

Journal: ACS Chem Neurosci

PubMed ID: 38433380

Doi: 10.1021/acschemneuro.3c00852

Products & Services: Molecular Biology Reagents

23-Hydroxybetulinic acid attenuates 5-fluorouracil resistance of colorectal cancer by modulating M2 macrophage polarization via STAT6 signaling

Authors: Zeping Fan, Yaru Cui, Lanying Chen, Peng Liu, Wenbin Duan

Journal: Cancer Immunol Immunother

PubMed ID: 38554148

Doi: 10.1007/s00262-024-03662-0

Products & Services: PCR Cloning and Subcloning

mmu-miR-374b-5p modulated inflammatory factors via downregulation of C/EBP β/NF-κB signaling in Kupffer cells during Echinococcus multilocularis infection

Authors: Guiting Pu, Yanping Li, Tingli Liu, Hong Li, Liqun Wang, Guoliang Chen, Shanling Cao, Hong Yin, Tharheer Oluwashola Amuda, Xiaola Guo, Xuenong Luo

Journal: Parasit Vectors

PubMed ID: 38553755

Doi: 10.1186/s13071-024-06238-0

Products & Services: Molecular Biology Reagents

Nanopore analysis of cis-diols in fruits

Authors: Pingping Fan, Zhenyuan Cao, Shanyu Zhang, Yuqin Wang, Yunqi Xiao, Wendong Jia, Panke Zhang, Shuo Huang

Journal: Nat Commun

PubMed ID: 38443434

Doi: 10.1038/s41467-024-46303-x

Products & Services: Molecular Biology Reagents

A pattern recognition receptor interleukin-1 receptor is involved in reproductive immunity in Macrobrachium nipponense ovary

Authors: Haifu Wan, Lei Yu, Xiaodong Cui, Shuai Guo, Shumei Mu, Xianjiang Kang

Journal: Fish Shellfish Immunol

PubMed ID: 38479568

Doi: 10.1016/j.fsi.2024.109481

Products & Services: Recombinant Proteins

Bacillus cereus cereolysin O induces pyroptosis in an undecapeptide-dependent manner

Authors: Yujian Wang, Jingchang Luo, Xiaolu Guan , Yan Zhao , Li Sun

Journal: Cell Death Discov

PubMed ID: 38458999

Doi: 10.1038/s41420-024-01887-7

Products & Services: Protein and Antibody Isolation

Endothelial β-catenin upregulation and Y142 phosphorylation drive diabetic angiogenesis via upregulating KDR/HDAC9

Authors: Zhenfeng Chen, Bingqi Lin, Xiaodan Yao, Jie Weng, Jinlian Liu, Qi He, Ke Song, Chuyu Zhou, Zirui Zuo, Xiaoxia Huang, Zhuanhua Liu, Qiaobing Huang, Qiulin Xu, Xiaohua Guo

Journal: Cell Commun Signal

PubMed ID: 38491522

Doi: 10.1186/s12964-024-01566-1

Products & Services: Recombinant Proteins

Reactive Oxygen Species-Responsive Nanoparticles Toward Extracellular Matrix Normalization for Pancreatic Fibrosis Regression

Authors: Liang Qi, Bo-Wen Duan, Hui Wang, Yan-Jun Liu, Han Han, Meng-Meng Han, Lei Xing, Hu-Lin Jiang, Stephen J Pandol, Ling Li

Journal: Adv Sci (Weinh)

PubMed ID: 38483920

Doi: 10.1002/advs.202401254

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Modular vector assembly enables rapid assessment of emerging CRISPR technologies

Authors: Abby V McGee, Yanjing V Liu, Audrey L Griffith, Zsofia M Szegletes, Bronte Wen, Carolyn Kraus, Nathan W Miller, Ryan J Steger, Berta Escude Velasco, Justin A Bosch, Jonathan D Zirin, Raghuvir Viswanatha, Erik J Sontheimer, Amy Goodale, Matthew A Greene, Thomas M Green, John G Doench

Journal: Cell Genom

PubMed ID: 38484704

Doi: 10.1016/j.xgen.2024.100519

Products & Services: Gene Synthesis

Preclinical Development of a Novel Epitope-based DNA Vaccine Candidate against SARS-CoV-2 and Evaluation of Immunogenicity in BALB/c Mice

Authors: Kanwal Khalid, Hui Xuan Lim, Ayaz Anwar, Soon Hao Tan, Jung Shan Hwang, Seng-Kai Ong, Chit Laa Poh

Journal: AAPS PharmSciTech

PubMed ID: 38472523

Doi: 10.1208/s12249-024-02778-x

Products & Services: Protein and Antibody Isolation

Nanomolar anti-SARS-CoV-2 Omicron activity of the host-directed TMPRSS2 inhibitor N-0385 and synergistic action with direct-acting antivirals

Authors: Jimena Pérez-Vargas, Gabriel Lemieux, Connor A H Thompson, Antoine Désilets, Siobhan Ennis, Guang Gao, Danielle G Gordon, Annika Lea Schulz, Masahiro Niikura, Ivan Robert Nabi, Mel Krajden, Pierre-Luc Boudreault, Richard Leduc, François Jean

Journal: Antiviral Res

PubMed ID: 38548023

Doi: 10.1016/j.antiviral.2024.105869

Products & Services: Molecular Biology Reagents

ATX1 and HUB1/2 promote recruitment of the transcription elongation factor VIP2 to modulate the floral transition in Arabidopsis

Authors: Qianqian Lu, Wenwen Shi, Fei Zhang, Yong Ding

Journal: Plant J

PubMed ID: 38446797

Doi: 10.1111/tpj.16707

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Small-molecule caspase-1 inhibitor CZL80 terminates refractory status epilepticus via inhibition of glutamatergic transmission

Authors: Fei Wang, Yu Wang, Qing-Yang Zhang, Ke-Yu Hu, Ying-Jie Song, Lin Yang, Fan Fei, Ceng-Lin Xu, Sun-Liang Cui, Ye-Ping Ruan, Yi Wang, Zhong Chen

Journal: Acta Pharmacol Sin

PubMed ID: 38514863

Doi: 10.1038/s41401-024-01257-0

Products & Services: Protein Electrophoresis and Western

HTRA1 disaggregates α-synuclein amyloid fibrils and converts them into non-toxic and seeding incompetent species

Authors: Sheng Chen, Anuradhika Puri, Braxton Bell, Joseph Fritsche, Hector H Palacios, Maurie Balch, Macy L Sprunger, Matthew K Howard, Jeremy J Ryan, Jessica N Haines, Gary J Patti, Albert A Davis, Meredith E Jackrel

Journal: Nat Commun

PubMed ID: 38499535

Doi: 10.1038/s41467-024-46538-8

Products & Services: Molecular Biology Reagents

Construction of recombinant pseudorabies virus expressing PCV2 Cap, PCV3 Cap, and IL-4: investigation of their biological characteristics and immunogenicity

Authors: Yanting Yang, Zhiwen Xu, Qian Tao, Lei Xu, Sirui Gu, Yao Huang, Zheyan Liu, Yang Zhang, Jianhua Wen, Siyuan Lai, Ling Zhu

Journal: Front Immunol

PubMed ID: 38571947

Doi: 10.3389/fimmu.2024.1339387

Products & Services: Molecular Biology Reagents

Expanding the molecular language of protein liquid-liquid phase separation

Authors: Shiv Rekhi, Cristobal Garcia Garcia, Mayur Barai, Azamat Rizuan, Benjamin S Schuster, Kristi L Kiick, Jeetain Mittal

Journal: Nat Chem

PubMed ID: 38553587

Doi: 10.1038/s41557-024-01489-x

Products & Services: Molecular Biology Reagents

A Novel Dual-Fc Bispecific Antibody with Enhanced Fc Effector Function

Authors: Fulai Zhou, Yinyin Ben, Hao Jiang, Siwen Tan, Guangmao Mu, Zhengxia Zha, Shuting Dong, Sheng Huang, Yijun Zhou, Ying Jin, Mark L Chiu

Journal: Biochemistry

PubMed ID: 38426700

Doi: 10.1021/acs.biochem.3c00481

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Long-term antigen-specific immune response by an oncolytic adenovirus encoding SP-SA-E7-4-1BBL in HPV-16 cancer model

Authors: Alejandra G Martinez-Perez, Rodolfo Garza-Morales, Maria de J Loera-Arias, Sheila A Villa-Cedillo, Aracely Garcia-Garcia, Humberto Rodriguez-Rocha, Orlando E Flores-Maldonado, Jesus Valdes, Jose J Perez-Trujillo, Odila Saucedo-Cardenas

Journal: Mol Biol Rep

PubMed ID: 38460043

Doi: 10.1007/s11033-024-09303-0

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Continuous evolution of compact protein degradation tags regulated by selective molecular glues

Authors: Jaron A M Mercer, Stephan J DeCarlo, Shourya S Roy Burman, Vedagopuram Sreekanth, Andrew T Nelson, Moritz Hunkeler, Peter J Chen, Katherine A Donovan, Praveen Kokkonda, Praveen K Tiwari, Veronika M Shoba, Arghya Deb, Amit Choudhary, Eric S Fischer, David R Liu

Journal: Science

PubMed ID: 38484051

Doi: 10.1126/science.adk4422

Products & Services: Protein and Antibody Isolation

Mutational analysis in Corynebacterium stationis MFS transporters for improving nucleotide bioproduction

Authors: Keita Kinose, Keiko Shinoda, Tomoyuki Konishi, Hisashi Kawasaki

Journal: Appl Microbiol Biotechnol

PubMed ID: 38436751

Doi: 10.1007/s00253-024-13080-y

Products & Services: Gene Synthesis

Characterization of Transthyretin Mutation G47V Associated with Hereditary Cardiac Amyloidosis

Authors: Xiaopeng He, Mengdie Wang, Jialu Sun, Zhengyang Yu, Xinyang Hu, Yu Liu, Xiaoping Lin

Journal: Cardiology

PubMed ID: 38437799

Doi: 10.1159/000538081

Products & Services: Molecular Biology Reagents

Characteristics of cold-adapted carbonic anhydrase and efficient carbon dioxide capture based on cell surface display technology

Authors: Yatong Wang, Quanfu Wang, Xuejing Shan, Yuwei Wu, Shumiao Hou, Ailin Zhang, Yanhua Hou

Journal: Bioresour Technol

PubMed ID: 38458264

Doi: 10.1016/j.biortech.2024.130539

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A combinatorial strategy for HRV 3C protease engineering to achieve the N-terminal free cleavage

Authors: Meng Mei, Xian Fan, Yu Zhou, Faying Zhang, Guimin Zhang, Li Yi

Journal: Int J Biol Macromol

PubMed ID: 38521339

Doi: 10.1016/j.ijbiomac.2024.131066

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A Versatile Platform to Generate Prodrugs with Rapid and Precise Albumin Hitchhiking and High Cargo Loading for Tumor-Targeted Chemotherapy

Authors: Jing Li, Huimin Xing, Jie Chen, Hongyu Lu, Ze Tao, Yiran Tao, Yunqing Sun, Tao Su, Xin Li, Huansheng Chang, Shiyuan Chen, Zhuo Chen, Hao Yang, Jingqiu Cheng, Hong Zhu, Xiaofeng Lu

Journal: Small

PubMed ID: 37963821

Doi: 10.1002/smll.202304253

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Caspase-2 protects against ferroptotic cell death

Authors: Swati Dawar, Mariana C Benitez, Yoon Lim, Toby A Dite, Jumana M Yousef, Niko Thio, Sylvain Garciaz, Thomas D Jackson, Julia V Milne, Laura F Dagley, Wayne A Phillips, Sharad Kumar, Nicholas J Clemons

Journal: Cell Death Dis

PubMed ID: 38429264

Doi: 10.1038/s41419-024-06560-6

Products & Services: Mutant Libraries

Uncovering the photosystem I assembly pathway in land plants

Authors: Aihong Zhang, Lin Tian, Tong Zhu, Mengyu Li, Mengwei Sun, Ying Fang, Yi Zhang, Congming Lu

Journal: Nat Plants

PubMed ID: 38503963

Doi: 10.1038/s41477-024-01658-3

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Knockout and Replacement Gene Surgery to Treat Rhodopsin-Mediated Autosomal Dominant Retinitis Pigmentosa

Authors: Xuehan Sun, Chen Liang, Yangcan Chen, Tongtong Cui, Jiabao Han, Moyu Dai, Ying Zhang, Qi Zhou, Wei Li

Journal: Hum Gene Ther

PubMed ID: 38368562

Doi: 10.1089/hum.2023.201

Products & Services: Molecular Biology Reagents