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RAGE Is a Receptor for SARS-CoV-2 N Protein and Mediates N Protein-induced Acute Lung Injury
Authors: Jie Xia, Jiangmei Wang, Liyang Ying, Ruoqiong Huang, Kai Zhang, Ruoyang Zhang, Wenqi Tang, Qi Xu, Dengming Lai, Yan Zhang, Yaoqin Hu, Xiaodie Zhang, Ruoxi Zang, Jiajie Fan, Qiang Shu, Jianguo Xu
Journal: Am J Respir Cell Mol Biol
PubMed ID: 37478333
Doi: 10.1165/rcmb.2022-0351OC
Products & Services: Recombinant Proteins   
ASPSCR-1 and Sirt-5 alleviate Clonorchis liver fluke rCsNOSIP-induced oxidative stress, proliferation, and migration in cholangiocarcinoma cells
Authors: Meng Bian, Shan Li, Hanzong Zhou, Lijun Bi, Yong Shen, Chen Tingjin, Xinbing Yu, Yan Huang, Qingxia Xu
Journal: PLoS Negl Trop Dis
PubMed ID: 37948465
Doi: 10.1371/journal.pntd.0011727
Products & Services: Gene Synthesis   
Molecular basis for the catalytic mechanism of human neutral sphingomyelinases 1 (hSMPD2)
Authors: Jingbo Yi, Boya Qi, Jian Yin, Ruochong Li, Xudong Chen, Junhan Hu, Guohui Li, Sensen Zhang, Yuebin Zhang, Maojun Yang
Journal: Nat Commun
PubMed ID: 38012235
Doi: 10.1038/s41467-023-43580-w
Structure-directed bioengineering the lid1 of cold-adapted Pseudomonas sp TB11 esterase to boost catalytic capacity
Authors: Linlin Sha, Wen-Sen He, Tian Zheng, Yang Fei, Yu Fang, Huqing Yang, Gang Chen
Journal: Int J Biol Macromol
PubMed ID: 37992944
Doi: 10.1016/j.ijbiomac.2023.128302
Products & Services: Gene Synthesis   
MiR126-targeted-nanoparticles combined with PI3K/AKT inhibitor as a new strategy to overcome melanoma resistance
Authors: Maria Beatrice Arasi, Gabriele De Luca, Laura Chronopoulou, Francesca Pedini, Eleonora Petrucci, Michela Flego, Annarita Stringaro, Marisa Colone, Luca Pasquini, Massimo Spada, Valentina Lulli, Maria Chiara Perrotta, George Adrian Calin, Cleofe Palocci, Mauro Biffoni, Federica Felicetti, Nadia Felli
Journal: Mol Ther
PubMed ID: 37990493
Doi: 10.1016/j.ymthe.2023.11.021
Products & Services: Molecular Biology Reagents   
Isolation and characterisation of PR3-specific B cells and their immunoglobulin sequences
Authors: Shane Kelly, Katherine Jl Jackson, Timothy J Peters, Dan Suan, Christopher C Goodnow
Journal: J Autoimmun
PubMed ID: 37952292
Doi: 10.1016/j.jaut.2023.103129
Products & Services: DNA Sequencing   
Denovo production of resveratrol by engineered Saccharomyces cerevisiae W303-1a using pretreated Gracilaria corticata extracts
Authors: Nishanthika Thenmozhi Kulasekaran, Mary Leema Thilakam, Dharani Gopal, Jung-Kul Lee, Jeya Marimuthu
Journal: Biotechnol Lett
PubMed ID: 37987932
Doi: 10.1007/s10529-023-03441-4
Products & Services: Molecular Biology Reagents   
Development of a highly efficient prime editor system in mice and rabbits
Authors: Yuqiang Qian , Di Wang , Wenchao Niu , Zheng Shi , Mao Wu , Ding Zhao , Jinze Li , Xun Gao , Zhongtian Zhang , Liangxue Lai , Zhanjun Li
Journal: Cell Mol Life Sci .
PubMed ID: 37924393
Doi: 10.1007/s00018-023-05003-3
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Interactions of Histone Deacetylase 6 with DNA Damage Repair Factors Strengthen its Utility as a Combination Drug Target in High-Grade Serous Ovarian Cancer
Authors: Jolene M Duda, Stefani N Thomas
Journal: ACS Pharmacol Transl Sci
PubMed ID: 38107255
Doi: 10.1021/acsptsci.3c00215
Critical role of TPRN rings in the stereocilia for hearing
Authors: Jieyu Qi, Fangzhi Tan, Liyan Zhang, Yinyi Zhou, Ziyu Zhang, Qiuhan Sun, Nianci Li, Yuan Fang, Xin Chen, Yunhao Wu, Guisheng Zhong, Renjie Chai
Journal: Mol Ther
PubMed ID: 37952086
Doi: 10.1016/j.ymthe.2023.11.011
DNAJB6 mutants display toxic gain of function through unregulated interaction with Hsp70 chaperones
Authors: Meital Abayev-Avraham, Yehuda Salzberg, Dar Gliksberg, Meital Oren-Suissa, Rina Rosenzweig
Journal: Nat Commun
PubMed ID: 37923706
Doi: 10.1038/s41467-023-42735-z
A role for cytoglobin in regulating intracellular hydrogen peroxide and redox signals in the vasculature
Authors: Clinton Mathai, Frances Jourd'heuil, Le Gia Cat Pham, Kurrim Gilliard, Joseph Balnis, Annie Jen, Katherine A Overmyer, Joshua J Coon, Ariel Jaitovich, Benoit Boivin, David Jourd'heuil
Journal: biorxiv
PubMed ID: 37034694
Doi: 10.1101/2023.03.31.535146
Regulated secretion of mutant p53 negatively affects T lymphocytes in the tumor microenvironment
Authors: Xiang Dong, Chunlu Li, Chengsi Deng, Jingwei Liu, Danni Li, Tingting Zhou, Xindi Yang, Yunchan Liu, Qiqiang Guo, Yanling Feng, Yang Yu, Zhuo Wang, Wendong Guo, Siyi Zhang, Hongyan Cui, Cui Jiang, Xiwen Wang, Xiaoyu Song, Xun Sun, Liu Cao
Journal: Oncogene
PubMed ID: 37952080
Doi: 10.1038/s41388-023-02886-1
A novel ultrasensitive assay for plasma p-tau217: Performance in individuals with subjective cognitive decline and early Alzheimer's disease
Authors: Fernando Gonzalez-Ortiz, Pamela C L Ferreira, Armand González-Escalante, Laia Montoliu-Gaya, Paula Ortiz-Romero, Przemyslaw R Kac, Michael Turton, Hlin Kvartsberg, Nicholas J Ashton, Henrik Zetterberg, Peter Harrison, Bruna Bellaver, Guilherme Povala, Victor L Villemagne, Tharick A Pascoal, Mary Ganguli, Anne D Cohen, Carolina Minguillon, Jose Contador, Marc Suárez-Calvet, Thomas K Karikari, Kaj Blennow
Journal: Alzheimers Dement
PubMed ID: 37975513
Doi: 10.1002/alz.13525
Plant carbonic anhydrase-like enzymes in neuroactive alkaloid biosynthesis
Authors: Ryan S Nett, Yaereen Dho, Chun Tsai, Daria Passow, Jaime Martinez Grundman, Yun-Yee Low, Elizabeth S Sattely
Journal: Nature
PubMed ID: 37938780
Doi: 10.1038/s41586-023-06716-y
Unlocking the potential of allogeneic Vδ2 T cells for ovarian cancer therapy through CD16 biomarker selection and CAR/IL-15 engineering
Authors: Derek Lee, Zachary Spencer Dunn, Wenbin Guo, Carl J Rosenthal, Natalie E Penn, Yanqi Yu, Kuangyi Zhou, Zhe Li, Feiyang Ma, Miao Li, Tsun-Ching Song, Xinjian Cen, Yan-Ruide Li, Jin J Zhou, Matteo Pellegrini, Pin Wang, Lili Yang
Journal: Nat Commun
PubMed ID: 37938576
Doi: 10.1038/s41467-023-42619-2
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Phages overcome bacterial immunity via diverse anti-defence proteins
Authors: Erez Yirmiya, Azita Leavitt, Allen Lu, Adelyn E Ragucci, Carmel Avraham, Ilya Osterman, Jeremy Garb, Sadie P Antine, Sarah E Mooney, Samuel J Hobbs, Philip J Kranzusch, Gil Amitai, Rotem Sorek
Journal: Nature
PubMed ID: 37992756
Doi: 10.1038/s41586-023-06869-w
Products & Services: Gene Synthesis   
A streamlined, automated workflow to screen and triage large numbers of baculoviruses for protein expression
Authors: James J Kostas, Andrea T Partridge, Noel J Byrne, Richard W Edwards, Hua-Poo Su, Sandra B Gabelli, Alexei Brooun, Jennifer M Shipman
Journal: Protein Expr Purif
PubMed ID: 37995943
Doi: 10.1016/j.pep.2023.106406
Products & Services: Molecular Biology Reagents   
Rational immunosilencing of a promiscuous T-cell epitope in the capsid of an adeno-associated virus
Authors: So Jin Bing, Morten Seirup, Trish T Hoang, Susana S Najera, Collin Britten, Stephanee L Warrington, Shiang-Ling Chu, Ronit Mazor
Journal: Nat Biomed Eng
PubMed ID: 37996615
Doi: 10.1038/s41551-023-01129-8
Products & Services: Peptide Synthesis   
Yeast Metabolic Engineering for Biosynthesis of Caffeic Acid-Derived Phenethyl Ester and Phenethyl Amide
Authors: Zi-Chen Jia, Duo Liu, Hai-Di Ma, Yu-Hui Cui, Hui-Min Li, Xia Li, Ying-Jin Yuan
Journal: ACS Synth Biol
PubMed ID: 38016187
Doi: 10.1021/acssynbio.3c00413
Products & Services: Molecular Biology Reagents   
Development of a multi-epitope vaccine candidate for leishmanial parasites applying immunoinformatics and approaches
Authors: Rahila Qureshi, Insaf Ahmed Qureshi
Journal: Front Immunol
PubMed ID: 38035118
Doi: 10.3389/fimmu.2023.1269774
Products & Services: Molecular Biology Reagents   
Environment relevant exposure of perfluorooctanoic acid accelerates the growth of hepatocellular carcinoma cells through mammalian target of rapamycin (mTOR) signal pathway
Authors: Jiawei Hong, Xiaoyan Wang, Hangbiao Jin, Yuanchen Chen, Yifan Jiang, Keyi Du, Diyu Chen, Shusen Zheng, Linping Cao
Journal: Environ Pollut
PubMed ID: 37967710
Doi: 10.1016/j.envpol.2023.122910
Cationic ribosomal proteins can inhibit pro-inflammatory action stimulated by LPS+HMGB1 and are hindered by advanced glycation end products
Authors: Masahiro Watanabe, Takao Toyomura, Hidenori Wake, Takashi Nishinaka, Omer Faruk Hatipoglu, Hideo Takahashi, Masahiro Nishibori, Shuji Mori
Journal: Biotechnol Appl Biochem
PubMed ID: 38010900
Doi: 10.1002/bab.2538
Products & Services: Molecular Biology Reagents   
Development of an Electrochemical, Aptamer-Based Sensor for Dynamic Detection of Neuropeptide Y
Authors: Jordan M Seibold, Sanduni W Abeykoon, Ashley E Ross, Ryan J White
Journal: ACS Sens
PubMed ID: 38033269
Doi: 10.1021/acssensors.3c00855
Products & Services: Recombinant Proteins   
Exosome-targeted delivery of METTL14 regulates NFATc1 m6A methylation levels to correct osteoclast-induced bone resorption
Authors: Jin-Gang Yang, Bao Sun, Zheng Wang, Xing Li, Jia-Hui Gao, Jia-Jun Qian, Jiang Li, Wen-Jia Wei, Ping Zhang, Wei Wang
Journal: Cell Death Dis
PubMed ID: 37957146
Doi: 10.1038/s41419-023-06263-4
The Peroxidase gene OsPrx114 Activated by OsWRKY50 Enhances Drought Tolerance through ROS Scavenging in Rice
Authors: Chao Zheng , Xuming Wang , Yue Xu , Shaomin Wang , Xin Jiang e , Xiuli Liub , Weijun Cui , Yueyan Wu , Chengqi Yan , Hongjia Liu , Yin Lu e, Jianping Chen a,b, and Jie Zhou
Journal: Plant Physiology and Biochemistry
Doi: 10.1016/j.plaphy.2023.108138
Unraveling the salt tolerance of Phi29 DNA polymerase using compartmentalized self-replication and microfluidics platform
Authors: Yaping Sun , Danny Hsu Ko , Jie Gao , Kang Fu , Yaping Gao , Qiwen Zhang , Salem Baldi , Tao Hong , Igor Ivanov , Yun He , Hui Tian
Journal: Front Microbiol .
PubMed ID: 38029082
Doi: 10.3389/fmicb.2023.1267196
Products & Services: Plasmid DNA Preparation   
Covalent Peptide LSD1 Inhibitor Specifically Recognizes Cys360 in the Enzyme-Active Region
Authors: Qinhong Luo , Yue Ma , Huiting Liang , Yuan Feng , Na Liu, Chenshan Lian , Lizhi Zhu , Yuxin Ye , Zhihong Liu , Zhanfeng Hou , Sijin Chen , Yaqi Wang , Chuan Dai , Chunli Song , Min Zhang , Zhipeng He , Yun Xing , Wanjin Zhong , Shuiming Li , Jianlong Wu , Fei Lu , Feng Yin , Zigang Li
Journal: J Med Chem .
PubMed ID: 37922441
Doi: 10.1021/acs.jmedchem.3c01549
Products & Services: Gene Synthesis   
Structural insights into asymmetric activation of the calciumsensing receptor–Gq complex
Authors: Shenglong Ling, Xianyu Meng, Yuan Zhang, Zhemin Xia, Yingxin Zhou, Fan Yang, Pan Shi, Chaowei Shi, Changlin Tian
Journal: Cell Res .
PubMed ID: 37919470
Doi: 10.1038/s41422-023-00892-2
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Protein kinase PfPK2 mediated signalling is critical for host erythrocyte invasion by malaria parasite
Authors: Rahul Singh Rawat, Ankit Gupta, Neelam Antil, Sonika Bhatnagar, Monika Singh, Akanksha Rawat, T S Keshava Prasad, Pushkar Sharma
Journal: PLoS Pathog
PubMed ID: 37988347
Doi: 10.1371/journal.ppat.1011770
Development of a sandwich ELISA to detect circulating, soluble IRAP as a potential disease biomarker
Authors: Anika Vear, Claudia Thalmann, Kristina Youngs, Natalie Hannan, Tracey Gaspari, Siew Yeen Chai
Journal: Sci Rep
PubMed ID: 38001104
Doi: 10.1038/s41598-023-44038-1
Targeting the COMMD4-H2B protein complex in lung cancer
Authors: Ming Tang, Joshua T Burgess, Mark Fisher, Didier Boucher, Emma Bolderson, Neha S Gandhi, Kenneth J O'Byrne, Derek J Richard, Amila Suraweera
Journal: Br J Cancer
PubMed ID: 37914802
Doi: 10.1038/s41416-023-02476-8
Engineering U1-Based Tetracycline-Inducible Riboswitches to Control Gene Expression in Mammals
Authors: Eric Rovira, Beatriz Moreno, Nerea Razquin, Lorea Blázquez, Ruben Hernández-Alcoceba, Puri Fortes, Fernando Pastor
Journal: ACS Nano
PubMed ID: 37971502
Doi: 10.1021/acsnano.3c01994
Products & Services: Molecular Biology Reagents   
Comparative Computational Analysis of Spike Protein Structural Stability in SARS-CoV-2 Omicron Subvariants
Authors: Anand Balupuri, Jeong-Min Kim, Kwang-Eun Choi, Jin Sun No, Il-Hwan Kim, Jee Eun Rhee, Eun-Jin Kim, Nam Sook Kang
Journal: Int J Mol Sci
PubMed ID: 38003257
Doi: 10.3390/ijms242216069
Products & Services: Molecular Biology Reagents   
Extracellular electron uptake from a cathode by the lactic acid bacterium
Authors: Sara Tejedor-Sanz, Siliang Li, Biki Bapi Kundu, Caroline M Ajo-Franklin
Journal: Front Microbiol
PubMed ID: 38075918
Doi: 10.3389/fmicb.2023.1298023
Products & Services: Molecular Biology Reagents   
IRGM is a novel regulator of PD-L1 via promoting S6K1-mediated phosphorylation of YBX1 in hepatocellular carcinoma
Authors: Junnan Ru, Jiahua Lu, Jiangzhen Ge, Bo Ding, Rong Su, Yifan Jiang, Yujing Sun, Jun Ma, Yu Li, Jingqi Sun, Guangming Xu, Rongliang Tong, Shusen Zheng, Beng Yang, Jian Wu
Journal: Cancer Lett
PubMed ID: 37993085
Doi: 10.1016/j.canlet.2023.216495
Products & Services: Recombinant Antibody Expression   
RNA is a key component of extracellular DNA networks in Pseudomonas aeruginosa biofilms
Authors: Sudarsan Mugunthan, Lan Li Wong, Fernaldo Richtia Winnerdy, Stephen Summers, Muhammad Hafiz Bin Ismail, Yong Hwee Foo, Tavleen Kaur Jaggi, Oliver W Meldrum, Pei Yee Tiew, Sanjay H Chotirmall, Scott A Rice, Anh Tuân Phan, Staffan Kjelleberg, Thomas Seviour
Journal: Nat Commun
PubMed ID: 38012164
Doi: 10.1038/s41467-023-43533-3
Products & Services: Gene Synthesis   
Retraction: Epitopes screening and vaccine molecular design of SADS-CoV based on immunoinformatics
Authors:
Journal: Front Vet Sci
PubMed ID: 38105774
Doi: 10.3389/fvets.2023.1342203
Products & Services: Gene Synthesis   
Delineation of DNA and mRNA COVID-19 vaccine-induced immune responses in preclinical animal models
Authors: Viviane M Andrade, Igor Maricic, Richa Kalia, Lauren Jachimowicz, Olivia Bedoya, Daniel W Kulp, Laurent Humeau, Trevor R F Smith
Journal: Hum Vaccin Immunother
PubMed ID: 38012018
Doi: 10.1080/21645515.2023.2281733
Diurnal regulation of alternative splicing associated with thermotolerance in rice by two glycine-rich RNA-binding proteins
Authors: Chuang Yang, Anni Luo, Hai-Ping Lu, Seth Jon Davis, Jian-Xiang Liu
Journal: Sci Bull (Beijing)
PubMed ID: 38044192
Doi: 10.1016/j.scib.2023.11.046
A Versatile Platform to Generate Prodrugs with Rapid and Precise Albumin Hitchhiking and High Cargo Loading for Tumor-Targeted Chemotherapy
Authors: Jing Li, Huimin Xing, Jie Chen, Hongyu Lu, Ze Tao, Yiran Tao, Yunqing Sun, Tao Su, Xin Li, Huansheng Chang, Shiyuan Chen, Zhuo Chen, Hao Yang, Jingqiu Cheng, Hong Zhu, Xiaofeng Lu
Journal: Small
PubMed ID: 37963821
Doi: 10.1002/smll.202304253
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Genetic manipulation of giant viruses and their host, Acanthamoeba castellanii
Authors: Nadege Philippe, Avi Shukla, Chantal Abergel, Hugo Bisio
Journal: Nat Protoc
PubMed ID: 37964008
Doi: 10.1038/s41596-023-00910-y
Products & Services: Custom DNA/RNA Oligos   
Sirtuin 3-mediated deacetylation of superoxide dismutase 2 ameliorates sodium fluoride-induced mitochondrial dysfunction in porcine oocytes
Authors: Xin-Yue Qi, Jin-Dong Yuan, Zi-Yu Liu, Xi-Qing Jiang, Qi Zhang, Shan-Long Zhang, Lu Zhao, Ling-Yan Ke, Chen-Yuan Zhang, Yan Li, Lu-Yan Zhang, Qian-Qian Xu, Zhong-Hua Liu, Jing-Tao Sun, Jun-Xue Jin
Journal: Sci Total Environ
PubMed ID: 37944611
Doi: 10.1016/j.scitotenv.2023.168306
Heterogeneity in the progression of retinal pathologies in mice harboring patient mimicking Impg2 mutations
Authors: Brittany N Williams, Adam Draper, Patrick F Lang, Tylor R Lewis, Audrey L Smith, Steven J Mayerl, Marie Rougié, Jeremy M Simon, Vadim Y Arshavsky, Scott H Greenwald, David M Gamm, Isabel Pinilla, Benjamin D Philpot
Journal: Hum Mol Genet
PubMed ID: 37975905
Doi: 10.1093/hmg/ddad199
Effect of Neutralizing Monoclonal Antibody Treatment on Early Trajectories of Virologic and Immunologic Biomarkers in Patients Hospitalized With COVID-19
Authors: Tomas O Jensen, Greg A Grandits, Mamta K Jain, Thomas A Murray, Birgit Grund, Kathryn Shaw-Saliba, Michael A Matthay, Mahsa Abassi, Magdalena Ardelt, Jason V Baker, Peter Chen, Robin L Dewar, Anna L Goodman, Timothy J Hatlen, Helene C Highbarger, Mark Holodniy, Perrine Lallemand, Sylvain Laverdure, Bradley G Leshnower, David Looney, Charalampos D Moschopoulos, Henry Mugerwa, Daniel D Murray, Eleftherios Mylonakis, Stephanie Nagy-Agren, M Tauseef Rehman, Adam Rupert, Randy A Stevens, Stuart Turville, Amy Weintrob, Katherine Wick, Jens Lundgren, Emily R Ko
Journal: J Infect Dis
PubMed ID: 37948759
Doi: 10.1093/infdis/jiad446
Regioselective Glycosylation of Polyphenols by Family 1 Glycosyltransferases: Experiments and Simulations
Authors: Ruben M de Boer, Dovydas Vaitkus, Kasper Enemark-Rasmussen, Sören Maschmann, David Teze, Ditte H Welner
Journal: ACS Omega
PubMed ID: 38075805
Doi: 10.1021/acsomega.3c08255
Autoimmune amelogenesis imperfecta in patients with APS-1 and coeliac disease
Authors: Yael Gruper, Anette S B Wolff, Liad Glanz, Frantisek Spoutil, Mihaela Cuida Marthinussen, Adriana Osickova, Yonatan Herzig, Yael Goldfarb, Goretti Aranaz-Novaliches, Jan Dobeš, Noam Kadouri, Osher Ben-Nun, Amit Binyamin, Bar Lavi, Tal Givony, Razi Khalaila, Tom Gome, Tomáš Wald, Blanka Mrazkova, Carmel Sochen, Marine Besnard, Shifra Ben-Dor, Ester Feldmesser, Elisaveta M Orlova, Csaba Hegedűs, István Lampé, Tamás Papp, Szabolcs Felszeghy, Radislav Sedlacek, Esti Davidovich, Noa Tal, Dror S Shouval, Raanan Shamir, Carole Guillonneau, Zsuzsa Szondy, Knut E A Lundin, Radim Osicka, Jan Prochazka, Eystein S Husebye, Jakub Abramson
Journal: Nature
PubMed ID: 37993717
Doi: 10.1038/s41586-023-06776-0
Mechanism of δ Mediated Transcription Activation in Bacillus subtilis: Interaction with α CTD of RNA Polymerase Stabilizes δ and Successively Facilitates the Open Complex Formation
Authors: Aniruddha Tewary, Ranjit Kumar Prajapati, Jayanta Mukhopadhyay
Journal: J Mol Biol
PubMed ID: 37972688
Doi: 10.1016/j.jmb.2023.168366
Ana Castillo Discusses Sexuality, Identity, and Life-Then and Now
Authors: Liliana C Gonzalez, Stacy I Macias
Journal: J Lesbian Stud
PubMed ID: 37791458
Doi: 10.1080/10894160.2023.2250670
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Molecular recognition of niacin and lipid-lowering drugs by the human hydroxycarboxylic acid receptor 2
Authors: Shengnan Zhu, Qingning Yuan, Xinzhu Li, Xinheng He, Shiyi Shen, Dongxue Wang, Junrui Li, Xi Cheng, Xiaoqun Duan, H Eric Xu, Jia Duan
Journal: Cell Rep
PubMed ID: 37952153
Doi: 10.1016/j.celrep.2023.113406
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