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Rapid and Mechanically Robust Immobilization of Proteins on Silica Studied at the Single-Molecule Level by Force Spectroscopy and Verified at the Macroscopic Level

Authors: Xiaoxu Zhang, Yayan Xie, Duo Huang, Xiaozhong Zhang, Xiaoyu Tang, Long Chen, Shi-Zhong Luo, Jizhong Lou, Chengzhi He

Journal: ACS Appl Mater Interfaces

PubMed ID: 38520330

Doi: 10.1021/acsami.3c18699

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Discordant Antigenic Properties of Soluble and Virion SARS-CoV-2 Spike Proteins

Authors: Sameer Kumar, Souradip Dasgupta, Mohammad M Sajadi, Greg A Snyder, Anthony L DeVico, Krishanu Ray

Journal: Viruses

PubMed ID: 38543772

Doi: 10.3390/v16030407

Products & Services: Molecular Biology Reagents

Highly stable and immunogenic CMV T cell vaccine candidate developed using a synthetic MVA platform

Authors: Marcal Yll-Pico, Yoonsuh Park, Joy Martinez, Angelina Iniguez, Mindy Kha, Taehyun Kim, Leonard Medrano, Vu H Nguyen, Teodora Kaltcheva, Shannon Dempsey, Flavia Chiuppesi, Felix Wussow, Don J Diamond

Journal: npj Vaccines

PubMed ID: 38555379

Doi: 10.1038/s41541-024-00859-3

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Authors: Yun Bai, Guanghua Cui, Xiaoke Sun, Meiqi Wei, Yanying Liu, Jialu Guo, Yu Yang

Journal: DNA Cell Biol

PubMed ID: 38466955

Doi: 10.1089/dna.2023.0392

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Flublok Quadrivalent Vaccine Adjuvanted with R-DOTAP Elicits a Robust and Multifunctional CD4 T Cell Response That Is of Greater Magnitude and Functional Diversity Than Conventional Adjuvant Systems

Authors: Chantelle L White, Maryah A Glover, Siva K Gandhapudi, Katherine A Richards, Andrea J Sant

Journal: Vaccines (Basel)

PubMed ID: 38543915

Doi: 10.3390/vaccines12030281

Products & Services: Recombinant Proteins

Haemolysins are essential to the pathogenicity of deep-sea Vibrio fluvialis

Authors: Yujian Wang, Jingchang Luo, Yan Zhao, Jian Zhang, Xiaolu Guan, Li Sun

Journal: iScience

PubMed ID: 38650982

Doi: 10.1016/j.isci.2024.109558

Products & Services: Molecular Biology Reagents

Poly(ADP-ribosyl)ation of TIMELESS limits DNA replication stress and promotes stalled fork protection

Authors: Julie Rageul , Natalie Lo , Amy L Phi , Jinal A Patel , Jennifer J Park , Hyungjin Kim

Journal: Cell Rep

PubMed ID: 38393943

Doi: 10.1016/j.celrep.2024.113845

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Oxysterol 25-hydroxycholesterol activation of ferritinophagy inhibits the development of squamous intraepithelial lesion of cervix in HPV-positive patients

Authors: Tianming Wang, Min Gong, Yingfei Lu, Chengcheng Zhao, Ling Ling, Jianquan Chen, Rong Ju

Journal: Cell Death Discov

PubMed ID: 38472192

Doi: 10.1038/s41420-024-01899-3

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A next generation peripherally restricted Cavα2δ-1 ligand with inhibitory action on Cav22 channels and utility in neuropathic pain

Authors: Franz Kricek, Christine Ruf, Premji Meghani, Ivana A Souza, Maria A Gandini, Gerald W Zamponi, George Skouteris

Journal: Biomed Pharmacother

PubMed ID: 38531121

Doi: 10.1016/j.biopha.2024.116472

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Novel PLCZ1 mutation caused polyspermy during in vitro fertilization

Authors: Ke-Ya Tong, Wei-Wei Liu, Li-Wei Sun, Dong-Yun Liu, Ye-Zhou Xiang, Chong Li, Lu-Wei Chai, Ke Chen, Guo-Ning Huang, Jing-Yu Li

Journal: Asian J Androl

PubMed ID: 38445955

Doi: 10.4103/aja202376

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Zebrafish mutants in egln1 display a hypoxic response and develop polycythemia

Authors: Xuehan Dou, Zhongyuan Chen, Yunzhang Liu, Yun Li, Junli Ye, Ling Lu

Journal: Life Sci

PubMed ID: 38492922

Doi: 10.1016/j.lfs.2024.122564

Products & Services: Mutant Libraries

piRNA loading triggers MIWI translocation from the intermitochondrial cement to chromatoid body during mouse spermatogenesis

Authors: Huan Wei, Jie Gao, Di-Hang Lin, Ruirong Geng, Jiaoyang Liao, Tian-Yu Huang, Guanyi Shang, Jiongjie Jing, Zong-Wei Fan, Duo Pan, Zi-Qi Yin, Tianming Li, Xinyu Liu, Shuang Zhao, Chen Chen, Jinsong Li, Xin Wang, Deqiang Ding, Mo-Fang Liu

Journal: Nat Commun

PubMed ID: 38491008

Doi: 10.1038/s41467-024-46664-3

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Influence of Mutations and N-Glycosylation Sites in the Receptor-Binding Domain (RBD) and the Membrane Protein of SARS-CoV-2 Variants of Concern on Antibody Binding in ELISA

Authors: Mandy Schwarze, Daniela Volke, Juan Camilo Rojas Echeverri, Robin Schick, Nicole Lakowa, Thomas Grünewald, Johannes Wolf, Stephan Borte, Markus Scholz, Andor Krizsan, Ralf Hoffmann

Journal: Biology (Basel)

PubMed ID: 38666819

Doi: 10.3390/biology13040207

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A common protein C inhibitor exosite partially controls the heparin induced activation and inhibition of serine proteases

Authors: Urfi Siddiqui, Abdul Burhan Khan, Tahif Ahmad, Ahmed Abdur Rehman, Mohamad Aman Jairajpuri

Journal: Int J Biol Macromol

PubMed ID: 38521329

Doi: 10.1016/j.ijbiomac.2024.131065

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OsWRKY78 regulates panicle exsertion via gibberellin signaling pathway in rice

Authors: Enyang Mei, Mingliang He, Min Xu, Jiaqi Tang, Jiali Liu, Yingxiang Liu, Zhipeng Hong, Xiufeng Li, Zhenyu Wang, Qingjie Guan, Xiaojie Tian, Qingyun Bu

Journal: J Integr Plant Biol

PubMed ID: 38470298

Doi: 10.1111/jipb.13636

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Branched chemically modified poly(A) tails enhance the translation capacity of mRNA

Authors: Hongyu Chen, Dangliang Liu, Jianting Guo, Abhishek Aditham, Yiming Zhou, Jiakun Tian, Shuchen Luo, Jingyi Ren, Alvin Hsu, Jiahao Huang, Franklin Kostas, Mingrui Wu, David R Liu, Xiao Wang

Journal: Nat Biotechnol

PubMed ID: 38519719

Doi: 10.1038/s41587-024-02174-7

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Proteins containing photosynthetic reaction centre domains modulate FtsZ-based archaeal cell division

Authors: Phillip Nußbaum, Danguole Kureisaite-Ciziene, Dom Bellini, Chris van der Does, Marko Kojic, Najwa Taib, Anna Yeates, Maxime Tourte, Simonetta Gribaldo, Martin Loose, Jan Löwe, Sonja-Verena Albers

Journal: Nat Microbiol

PubMed ID: 38443575

Doi: 10.1038/s41564-024-01600-5

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Structural insights into the Clp protein degradation machinery

Authors: Xiaolong Xu, Yanhui Wang, Wei Huang, Danyang Li, Zixin Deng, Feng Long

Journal: MBio

PubMed ID: 38501868

Doi: 10.1128/mbio.00031-24

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Study on the Thermal Stability of the Sweet-Tasting Protein Brazzein Based on Its Structure-Sweetness Relationship

Authors: Jingnan Zuo, Wei Zheng, Nian Shi, Rong Song, Fei Han, Chen Yang, Jingwen Li, Chao Peng, Bin Li, Yijie Chen

Journal: J Agric Food Chem

PubMed ID: 38526016

Doi: 10.1021/acs.jafc.3c09616

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Integrative high-throughput enhancer surveying and functional verification divulges a YY2-condensed regulatory axis conferring risk for osteoporosis

Authors: Xiao-Feng Chen, Yuan-Yuan Duan, Ying-Ying Jia, Qian-Hua Dong, Wei Shi, Yan Zhang, Shan-Shan Dong, Meng Li, Zhongbo Liu, Fei Chen, Xiao-Ting Huang, Ruo-Han Hao, Dong-Li Zhu, Rui-Hua Jing, Yan Guo, Tie-Lin Yang

Journal: Cell Genom

PubMed ID: 38335956

Doi: 1016/j.xgen.2024.100501

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Development of a colloidal gold immunochromatographic strip for rapid detection of avian coronavirus infectious bronchitis virus

Authors: Chang-Run Zhao, Li-Ting Lin, Jin-Wen Tang, Yu Zhang, Wen Zhang, Ji-Ming Chen, Ping Wei, Teng Huang, Tian-Chao Wei, Mei-Lan Mo

Journal: Poult Sci

PubMed ID: 38574460

Doi: 10.1016/j.psj.2024.103648.

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CIRP increases Foxp3 regulatory T cells and inhibits development of Th17 cells by enhancing TLR4-IL-2 signaling in the late phase of sepsis

Authors: Zongsheng Wu, Xu Liu, Wei Huang, Jing Chen, Songli Li, Jie Chao, Jianfeng Xie, Ling Liu, Yi Yang, Xiaojing Wu, Haibo Qiu

Journal: Int Immunopharmacol

PubMed ID: 38531201

Doi: 10.1016/j.intimp.2024.111924

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Impact of SARS-CoV-2 spike stability and RBD exposure on antigenicity and immunogenicity

Authors: Lucy Rutten, Maarten Swart, Annemart Koornneef, Pascale Bouchier, Sven Blokland, Ava Sadi, Jarek Juraszek, Aneesh Vijayan, Sonja Schmit-Tillemans, Johan Verspuij, Ying Choi, Chenandly E Daal, Aditya Perkasa, Shessy Torres Morales, Sebenzile K Myeni, Marjolein Kikkert, Jeroen Tolboom, Daniëlle van Manen, Harmjan Kuipers, Hanneke Schuitemaker, Roland Zahn, Johannes P M Langedijk

Journal: Sci Rep

PubMed ID: 38459086

Doi: 10.1038/s41598-024-56293-x

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Atrogin-1 promotes muscle homeostasis by regulating levels of endoplasmic reticulum chaperone BiP

Authors: Avnika A Ruparelia, Margo Montandon, Jo Merriner, Cheng Huang, Siew Fen Lisa Wong, Carmen Sonntag, Justin P Hardee, Gordon S Lynch, Lee B Miles, Ashley Siegel, Thomas E Hall, Ralf B Schittenhelm, Peter D Currie

Journal: JCI Insight

PubMed ID: 38530354

Doi: 10.1172/jci.insight.167578

Products & Services: Molecular Biology Reagents

Mucosal tumor vaccination delivering endogenous tumor antigens protects against pulmonary breast cancer metastases

Authors: Friederike Oltmanns, Ana Vieira Antão, Pascal Irrgang, Vera Viherlehto, Leticia Jörg, Anna Schmidt, Jannik T Wagner, Michael Rückert, Ann-Sophie Flohr, Carol Imanuel Geppert, Benjamin Frey, Wibke Bayer, Claudia Gravekamp, Matthias Tenbusch, Udo Gaipl, Dennis Lapuente

Journal: J Immunother Cancer

PubMed ID: 38458636

Doi: 10.1136/jitc-2023-008652

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CAR-engineered lymphocyte persistence is governed by a FAS ligand/FAS auto-regulatory circuit

Authors: Fei Yi, Tal Cohen, Natalie Zimmerman, Friederike Dündar, Paul Zumbo, Razan Eltilib, Erica J Brophy, Hannah Arkin, Judith Feucht, Michael V Gormally, Christopher S Hackett, Korbinian N Kropp, Inaki Etxeberria, Smita S Chandran, Jae H Park, Katharine C Hsu, Michel Sadelain, Doron Betel, Christopher A Klebanoff

Journal: biorxiv

PubMed ID: 38464085

Doi: 10.1101/2024.02.26.582108

Products & Services: Gene Synthesis

YAP/TAZ-TEAD activity promotes the malignant transformation of cervical intraepithelial neoplasia through enhancing the characteristics and Warburg effect of cancer stem cells

Authors: Shu Li, Xing Li, Yong-Bin Yang, Su-Fang Wu

Journal: Apoptosis

PubMed ID: 38553612

Doi: 10.1007/s10495-023-01935-0

Products & Services: Molecular Biology Reagents

Oxygen Activation in Aromatic Ring Cleaving Salicylate Dioxygenase: Detection of Reaction Intermediates with a Nitro-substituted Substrate Analog

Authors: Qian Wang, Hanbin Li, Uran Bujupi, Janosch Gröning, Andreas Stolz, Angelo Bongiorno, Rupal Gupta

Journal: Chembiochem

PubMed ID: 38363551

Doi: 10.1002/cbic.202400023

Products & Services: Molecular Biology Reagents

Structural basis for RAD18 regulation by MAGEA4 and its implications for RING ubiquitin ligase binding by MAGE family proteins

Authors: Simonne Griffith-Jones, Lucía Álvarez, Urbi Mukhopadhyay, Sarah Gharbi, Mandy Rettel, Michael Adams, Janosch Hennig, Sagar Bhogaraju

Journal: EMBO J

PubMed ID: 38448672

Doi: 10.1038/s44318-024-00058-9

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Exploring the role of disulfidptosis-related signatures in immune microenvironment, prognosis and therapeutic strategies of cervical cancer

Authors: Tianzhe Jin, Taotao Yin, Ruiyi Xu, Hong Liu, Shuo Yuan, Yite Xue, Jianwei Zhang, Hui Wang

Journal: Transl Oncol

PubMed ID: 38492499

Doi: 10.1016/j.tranon.2024.101938

Products & Services: Protein Electrophoresis and Western

Involvement of TGFBI-TAGLN axis in cancer stem cell property of head and neck squamous cell carcinoma

Authors: Motoharu Sarubo, Yasuhiro Mouri, Akira Moromizato, Azusa Yamada, Shengjan Jin, Wenhua Shao, Hiroko Hagita, Keiko Miyoshi, Yasusei Kudo

Journal: Sci Rep

PubMed ID: 38514830

Doi: 10.1038/s41598-024-57478-0

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Saikosaponin d protects pancreatic acinar cells against cerulein-induced pyroptosis through alleviating mitochondrial damage and inhibiting cGAS-STING pathway

Authors: Hui Chen, Xirong Lu, Beiqi Xu, Gang Cheng, Yuyi Li, Dan Xie

Journal: J Appl Toxicol

PubMed ID: 38462915

Doi: 10.1002/jat.4594

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Enhancing precision medicine: Bispecific antibody-mediated targeted delivery of lipid nanoparticles for potential cancer therapy

Authors: Yue Zhang, Xiaoyan Gu, Lili Huang, Yani Yang, Jun He

Journal: Int J Pharm

PubMed ID: 38467208

Doi: 10.1016/j.ijpharm.2024.123990

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Phoenixin 20 ameliorates pulmonary arterial hypertension via inhibiting inflammation and oxidative stress

Authors: Yaqin Chai, Xing Gu, HongJun Zhang, Xinting Xu, Lizhan Chen

Journal: Aging (Albany NY)

PubMed ID: 38517365

Doi: 10.18632/aging.205468

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4'--MethylbavachalconeB Targeted 14-3-3ζ Blocking the Integrin β3 Early Outside-In Signal to Inhibit Platelet Aggregation and Thrombosis

Authors: Ziqi Tang, Fanqi Lin, Zhiwen Chen, Boyang Yu, Ji-Hua Liu, Xiufeng Liu

Journal: J Agric Food Chem

PubMed ID: 38509000

Doi: 10.1021/acs.jafc.3c05211

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Construction by artificial intelligence and immunovalidation of hypoallergenic mite allergen Der f 36 vaccine

Authors: Qiao-Zhi Qin, Jian Tang, Cai-Yun Wang, Zhi-Qiang Xu, Man Tian

Journal: Front Immunol

PubMed ID: 38601166

Doi: 10.3389/fimmu.2024.1325998

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IgG hexamers initiate complement-dependent acute lung injury

Authors: Simon J Cleary, Yurim Seo, Jennifer J Tian, Nicholas Kwaan, David P Bulkley, Arthur Eh Bentlage, Gestur Vidarsson, Éric Boilard, Rolf Spirig, James C Zimring, Mark R Looney

Journal: J Clin Invest

PubMed ID: 38530369

Doi: 10.1172/JCI178351

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The replication phenotype of hepatitis B virus (HBV) splice variants Sp3 and Sp9 and their impact on wild-type HBV replication

Authors: Laura C McCoullough, Tomas Sadauskas, Vitina Sozzi, Kai Yan Mak, Hugh Mason, Margaret Littlejohn, Peter A Revill

Journal: J Virol

PubMed ID: 38501924

Doi: 10.1128/jvi.01538-23

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A shared neoantigen vaccine combined with immune checkpoint blockade for advanced metastatic solid tumors: phase 1 trial interim results

Authors: Amy R Rappaport, Chrisann Kyi, Monica Lane, Meghan G Hart, Melissa L Johnson, Brian S Henick, Chih-Yi Liao, Amit Mahipal, Ardaman Shergill, Alexander I Spira, Jonathan W Goldman, Ciaran D Scallan, Desiree Schenk, Christine D Palmer, Matthew J Davis, Sonia Kounlavouth, Lindsey Kemp, Aaron Yang, Yaojun John Li, Molly Likes, Annie Shen, Gregory R Boucher, Milana Egorova, Robert L Veres, J Aaron Espinosa, Jason R Jaroslavsky, Lauren D Kraemer Tardif, Lindsey Acrebuche, Christopher Puccia, Leiliane Sousa, Rita Zhou, Kyounghwa Bae, J Randolph Hecht, David P Carbone, Benny Johnson, Andrew Allen, Andrew R Ferguson, Karin Jooss

Journal: Nat Med

PubMed ID: 38538867

Doi: 10.1038/s41591-024-02851-9

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Long-term effects of Omicron BA2 breakthrough infection on immunity-metabolism balance: a 6-month prospective study

Authors: Yanhua Li, Shijie Qin, Lei Dong, Shitong Qiao, Xiao Wang, Dongshan Yu, Pengyue Gao, Yali Hou, Shouzhen Quan, Ying Li, Fengyan Fan, Xin Zhao, Yueyun Ma, George Fu Gao

Journal: Nat Commun

PubMed ID: 38503738

Doi: 10.1038/s41467-024-46692-z

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Identification of mA RNA methylation genes in and expression profiling in response to different developmental and environmental stimuli

Authors: Mahbub Hasan, Zakia Sultana Nishat, Md Soyib Hasan, Tanvir Hossain, Ajit Ghosh

Journal: Biochem Biophys Rep

PubMed ID: 38511186

Doi: 10.1016/j.bbrep.2024.101677

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HERC5-catalyzed ISGylation potentiates cGAS-mediated innate immunity

Authors: Lei Chu, Li Qian, Yu Chen, Shengnan Duan, Ming Ding, Wu Sun, Wei Meng, Juanjuan Zhu, Quanyi Wang, Haiping Hao, Chen Wang, Shufang Cui

Journal: Cell Reports

PubMed ID: 38421872

Doi: 10.1016/j.celrep.2024.113870

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GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against cancer

Authors: Zu Ye, Shengfeng Xu, Yin Shi, Xueqian Cheng, Yuan Zhang, Sunetra Roy, Sarita Namjoshi, Michael A Longo, Todd M Link, Katharina Schlacher, Guang Peng, Dihua Yu, Bin Wang, John A Tainer, Zamal Ahmed

Journal: Nature Communications

PubMed ID: 38459011

Doi: 10.1038/s41467-024-46283-y.

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An oncolytic vaccinia virus encoding hyaluronidase reshapes the extracellular matrix to enhance cancer chemotherapy and immunotherapy

Authors: Shibing Wang, Yuxin Li, Chuning Xu, Jie Dong, Jiwu Wei

Journal: J Immunother Cancer

PubMed ID: 38458640

Doi: 10.1136/jitc-2023-008431

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Design and Preclinical Evaluation of a Nanoparticle Vaccine against Respiratory Syncytial Virus Based on the Attachment Protein G

Authors: Richard Voorzaat, Freek Cox, Daan van Overveld, Lam Le, Lisanne Tettero, Joost Vaneman, Mark J G Bakkers, Johannes P M Langedijk

Journal: Vaccines (Basel)

PubMed ID: 38543928

Doi: 10.3390/vaccines12030294

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An Engineered Laccase from Accelerates Lignocellulose Degradation

Authors: Le Thanh Mai Pham, Kai Deng, Hemant Choudhary, Trent R Northen, Steven W Singer, Paul D Adams, Blake A Simmons, Kenneth L Sale

Journal: Biomolecules

PubMed ID: 38540744

Doi: 10.3390/biom14030324

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In vitro digestion mimicking conditions in adults and elderly reveals digestive characteristics of pork from different cooking ways

Authors: Xiangyue Cao, Fan Zhao, Ziyi Lin, Xiaomei Sun, Xianming Zeng, Haoxi Liu, Yutong Li, Zihang Yuan, Yuan Su, Chong Wang, Guanghong Zhou

Journal: Food Res Int

PubMed ID: 38760136

Doi: 10.1016/j.foodres.2024.114204

Products & Services: Protein and Antibody Isolation

Antibody targeting of surface P-selectin glycoprotein ligand 1 leads to lymphoma apoptosis and tumorigenesis inhibition

Authors: João L Pereira, Francisca Ferreira, Nuno R Dos Santos

Journal: Hematol Oncol

PubMed ID: 38415859

Doi: 10.1002/hon.3257

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AIRE is expressed in breast cancer TANs and TAMs to regulate the extrinsic apoptotic pathway and inflammation

Authors: Eva Källberg, Meliha Mehmeti-Ajradini, Frida Björk Gunnarsdottir, Marcus Göransson, Caroline Bergenfelz, Roni Allaoui Fredriksson, Catharina Hagerling, Martin E Johansson, Charlotte Welinder, Karin Jirström, Karin Leandersson

Journal: J Leukoc Biol

PubMed ID: 38060995

Doi: 10.1093/jleuko/qiad152

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Biochemical and structural analysis of N-myristoyltransferase mediated protein tagging

Authors: Paul Monassa , Frédéric Rivière , Cyril Dian , Frédéric Frottin , Carmela Giglione , Thierry Meinnel

Journal: Methods Enzymol .

PubMed ID: 37230587

Doi: 10.1016/bs.mie.2023.02.016

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