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Detecting m6A at single-molecular resolution via direct RNA sequencing and realistic training data

Authors: Adrian Chan, Isabel S Naarmann-de Vries, Carolin P M Scheitl, Claudia Höbartner,Christoph Dieterich

Journal: Nature Communications

PubMed ID: 38637518

Doi: 10.1038/s41467-024-47661-2

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Assembly of SARS-CoV-2 nucleocapsid protein with nucleic acid

Authors: Huaying Zhao, Abdullah M Syed, Mir M Khalid, Ai Nguyen, Alison Ciling, Di Wu, Wai-Ming Yau, Sanjana Srinivasan, Dominic Esposito, Jennifer A Doudna, Grzegorz Piszczek, Melanie Ott, Peter Schuck

Journal: Nucleic Acids Res

PubMed ID: 38587193

Doi: 10.1093/nar/gkae256

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Assessing Weak Anion Binding to Small Peptides

Authors: Corinne L D Gibb, Thien H Tran, Bruce C Gibb

Journal: Journal of the American Chemical Society

PubMed ID: 38592238

Doi: 10.1021/acs.jpcb.4c00657

Products & Services: Peptide Synthesis

Structural Insights into the Unexpected Agonism of Tetracyclic Antidepressants at Serotonin Receptors 5-HT1eR and 5-HT1FR

Authors: Gregory Zilberg, Alexandra K Parpounas, Audrey L Warren, Bianca Fiorillo, Davide Provasi, Marta Filizola, Daniel Wacker

Journal: SCIENCE ADVANCES

PubMed ID: 37986777

Doi: 10.1101/2023.10.05.561100

Products & Services: Protein and Antibody Isolation

Immune microniches shape intestinal T function

Authors: Yisu Gu, Raquel Bartolomé-Casado, Chuan Xu, Alice Bertocchi, Alina Janney, Cornelia Heuberger, Claire F Pearson, Sarah A Teichmann, Emily E Thornton, Fiona Powrie

Journal: Nature

PubMed ID: 38570678

Doi: 10.1038/s41586-024-07251-0

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Antibacterial efficacy and mechanism of Cyprinus carpio chemokine-derived L-10 against multidrug-resistant Escherichia coli infections

Authors: Hao Lu, Chenchen Wang, Wenjia Lu, Xiaodan Li, Gaoyan Wang, Wenqi Dong, Xiangru Wang, Huanchun Chen, Chen Tan

Journal: International journal of antimicrobial agents

PubMed ID: 38325720

Doi: 10.1016/j.ijantimicag.2024.107104

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Phenotypic characterization of sorghum seedlings and expression patterns of SNAC1 and DREB1A genes under water‑stress: an insight towards developing resilient cultivars

Authors: David Adedayo Animasaun · Khadijat Adetoun Adedoyin · Afeez Taiwo Bakare · Kabir Adeniran Mustapha · Mary Anuoluwapo Akinbobola · Kafayat Folasade Awujoola · Jonathan Toyin Ogunjobi

Journal: springerlink

Doi: 10.1007/s10722-024-01956-x

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Decoding chromatin states by proteomic profiling of nucleosome readers

Authors: Saulius Lukauskas, Andrey Tvardovskiy, Nhuong V Nguyen , Mara Stadler, Peter Faull, Tina Ravnsborg, Bihter Özdemir Aygenli, Scarlett Dornauer, Helen Flynn, Rik G H Lindeboom, Teresa K Barth, Kevin Brockers, Stefanie M Hauck, Michiel Vermeulen, Ambrosius P Snijders, Christian L Müller, Peter A DiMaggio, Ole N Jensen, Robert Schneider, Till Bartke

Journal: Nature

PubMed ID: 38448585

Doi: 10.1038/s41586-024-07141-5

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Alternative low-populated conformations prompt phase transitions in polyalanine repeat expansions

Authors: Rosa Antón, Miguel Á Treviño, David Pantoja-Uceda, Sara Félix, María Babu, Eurico J Cabrita, Markus Zweckstetter, Philip Tinnefeld, Andrés M Vera, Javier Oroz

Journal: Nature

PubMed ID: 38431667

Doi: 10.1038/s41467-024-46236-5

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Filamentous fungus-produced human monoclonal antibody provides protection against SARS-CoV-2 in hamster and non-human primate models

Authors: Franziska K Kaiser, Mariana Gonzalez Hernandez, Nadine Krüger, Ellinor Englund, Wenjuan Du, Anna Z Mykytyn, Mathijs P Raadsen, Mart M Lamers

Journal: Nature Communications

PubMed ID: 38485931

Doi: 10.1038/s41467-024-46443-0

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Human IgG Fc-engineering for enhanced plasma half-life, mucosal distribution and killing of cancer cells and bacteria

Authors: Stian Foss , Siri A Sakya, Leire Aguinagalde, Marta Lustig, Jutamas Shaughnessy, Ana Rita Cruz , Lisette Scheepmaker, Line Mathiesen, Fulgencio Ruso-Julve, Aina Karen Anthi, Torleif Tollefsrud Gjølberg

Journal: Nature Communications

PubMed ID: 38453922

Doi: 10.1038/s41467-024-46321-9

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An alphacoronavirus polymerase structure reveals conserved replication factor functions

Authors: Thomas K Anderson, Peter J Hoferle, Kennan J Chojnacki, Kenneth W Lee, Joshua J Coon, Robert N Kirchdoerfer

Journal: Nucleic Acids Research

PubMed ID: 38442273

Doi: 10.1093/nar/gkae153

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Determinants of CRISPR Cas12a nuclease activation by DNA and RNA targets

Authors: Eric A Nalefski, Remy M Kooistra, Ishira Parikh, Samantha Hedley, Karunya Rajaraman, Damian Madan

Journal: Nucleic Acids Research

PubMed ID: 38477377

Doi: 10.1093/nar/gkae152

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A distinct tumor microenvironment makes anaplastic thyroid cancer more lethal but immunotherapy sensitive than papillary thyroid cancer

Authors: Pei-Zhen Han, Wei-Dong Ye, Peng-Cheng Yu, Li-Cheng Tan, Xiao Shi, Xu-Feng Chen, Cong He, Jia-Qian Hu, Wen-Jun Wei, Zhong-Wu Lu, Ning Qu, Yu Wang, Qing-Hai Ji, Dong-Mei Ji, Yu-Long Wang

Journal: JCI Insight

PubMed ID: 38478516

Doi: 10.1172/jci.insight.173712

Products & Services: Molecular Biology Reagents

Structurally Diverse Bisbenzylisoquinoline Alkaloids with Antiadipogenic Activity through Downregulation from the Embryo of Seeds

Authors: Peiliang Zhang, Jiadong Li, Jiyao Shi, Zhihong Cheng, Tao Wu

Journal: J Nat Prod

PubMed ID: 38483204

Doi: 10.1021/acs.jnatprod.3c01290

Products & Services: Protein and Antibody Isolation

Effects of Drag-Reducing Polymers on Hemodynamics and Whole Blood-Endothelial Interactions in 3D-Printed Vascular Topologies

Authors: Louis S Paone, Matthew Szkolnicki, Brandon J DeOre, Kiet A Tran, Noah Goldman, Allison M Andrews, Servio H Ramirez, Peter A Galie

Journal: ACS Appl Mater Interfaces

PubMed ID: 38488736

Doi: 10.1021/acsami.3c17099

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The Novel MFG-E8-derived Oligopeptide, MOP3, Improves Outcomes in a Preclinical Murine Model of Neonatal Sepsis

Authors: Colleen P Nofi, Jose M Prince, Monowar Aziz, Ping Wang

Journal: J Pediatr Surg

PubMed ID: 38582704

Doi: 10.1016/j.jpedsurg.2024.03.025

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LINC00869 Promotes Hepatocellular Carcinoma Metastasis via Protrusion Formation

Authors: Xiaowen Shao, Yamei Dang, Tingting Zhang, Nan Bai, Jianing Huang, Mengya Guo, Li Sun, Minghe Li, Xiao Sun, Xinran Zhang, Feng Han, Ning Zhang, Hao Zhuang, Yongmei Li

Journal: Mol Cancer Res

PubMed ID: 37934195

Doi: 10.1158/1541-7786.MCR-23-0414

Products & Services: Protein and Antibody Isolation

Separation and purification of short-, medium-, and long-stranded RNAs by RP-HPLC using different mobile phases and C columns with various pore sizes

Authors: Makoto Ozaki, Tomomi Kuwayama, Motoshi Shimotsuma, Tsunehisa Hirose

Journal: Anal Methods

PubMed ID: 38445900

Doi: 10.1039/d4ay00114a

Products & Services: Gene Synthesis

Immunoprotective effect and mechanism of rEgP29 against CD4 T cell-deficient mice with infection

Authors: Ming Li, Yazhou Zhu, Zihua Li, Jiahui Song, Wei Zhao

Journal: Acta Biochim Biophys Sin (Shanghai)

PubMed ID: 38151996

Doi: 10.3724/abbs.2023282

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Structural insights into peptidoglycan glycosidase EtgA binding to the inner rod protein EscI of the type III secretion system via a designed EscI-EtgA fusion protein

Authors: J Boorman, X Zeng, J Lin, F van den Akker

Journal: Protein Sci

PubMed ID: 38380768

Doi: 10.1002/pro.4930

Products & Services: Protein and Antibody Isolation

Computational aptamer design for spike glycoprotein (S) (SARS CoV-2) detection with an electrochemical aptasensor

Authors: Alessia Cossettini, Laura Pasquardini, Antonello Romani, Aldo Feriani, Debora Pinamonti, Marisa Manzano

Journal: Appl Microbiol Biotechnol

PubMed ID: 38470514

Doi: 10.1007/s00253-024-13066-w

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Exploring the enigmatic association between PNLIP variants and risk of chronic pancreatitis in a large Chinese cohort

Authors: Brett M Cassidy, Fei Jiang, Jianguo Lin, Jian-Min Chen, Grace E Curry, Guo-Xiu Ma, Steven J Wilhelm, Shun-Jiang Deng, Guoying Zhu, Zhuan Liao, Mark E Lowe, Xunjun K Xiao, Wen-Bin Zou

Journal: Pancreatology

PubMed ID: 38485544

Doi: 10.1016/j.pan.2024.03.002

Products & Services: Mutagenesis Services

WDR4 promotes HCC pathogenesis through N-methylguanosine by regulating and interacting with METTL1

Authors: Rui Dong, Chuanxu Wang, Bo Tang, Yayu Cheng, Xuehui Peng, Xiaomin Yang, Bing Ni, Jing Li

Journal: Cell Signal

PubMed ID: 38493882

Doi: 10.1016/j.cellsig.2024.111145

Products & Services: Protein and Antibody Isolation

Cross-reactive CD8 T cell responses to tumor-associated antigens (TAAs) and homologous microbiota-derived antigens (MoAs)

Authors: Beatrice Cavalluzzo, Marie Christine Viuff, Siri Amanda Tvingsholm, Concetta Ragone, Carmen Manolio, Angela Mauriello, Franco M Buonaguro, Maria Lina Tornesello, Francesco Izzo, Alessandro Morabito, Sine Reker Hadrup, Maria Tagliamonte, Luigi Buonaguro

Journal: J Exp Clin Cancer Res

PubMed ID: 38509571

Doi: 10.1186/s13046-024-03004-z

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Inhibitory effects of senkyuchachosan on SARS-CoV-2 papain-like protease activity in vitro

Authors: Yuka Kiba, Takashi Tanikawa, Tsuyoshi Hayashi, Takami Yokogawa, Aiko Sano, Ryuichiro Suzuki, Masashi Kitamura

Journal: J Nat Med

PubMed ID: 38512650

Doi: 10.1007/s11418-024-01788-0

Products & Services: Molecular Biology Reagents

The Hsa_circ_0105558/miR-182-5p/ATF6 Cascade Affects HO-Triggered Oxidative Damage and Apoptosis of Human Lens Epithelial Cells

Authors: Wei Mao, Zhe Zhang

Journal: Biochem Genet

PubMed ID: 38530576

Doi: 10.1007/s10528-024-10753-1

Products & Services: Molecular Biology Reagents

Diagnosis of fasciolosis antibodies in Brazilian cattle through ELISA employing both native and recombinant antigens

Authors: Guilherme Drescher, Hellen Geremias Dos Santos, Mariane Marques da Guarda Pinto, Luis Gustavo Morello, Fabiano Borges Figueiredo

Journal: Microbiol Spectr

PubMed ID: 38534120

Doi: 10.1128/spectrum.00095-24

Products & Services: Molecular Biology Reagents

Structural insights into human EMC and its interaction with VDAC

Authors: Mingyue Li, Chunli Zhang, Yuntao Xu, Shaobai Li, Chenhui Huang, Jian Wu, Ming Lei

Journal: Aging (Albany NY)

PubMed ID: 38517390

Doi: 10.18632/aging.205660

Products & Services: Protein and Antibody Isolation

Fibrinogen deposition promotes neuroinflammation and fibrin-derived γ peptide ameliorates neurological deficits after ischemic stroke

Authors: Lu Han, Yaying Song, Weiwei Xiang, Ze Wang, Yishu Wang, Xiajun Zhou, De-Sheng Zhu, Yangtai Guan

Journal: Int Immunopharmacol

PubMed ID: 38489969

Doi: 10.1016/j.intimp.2024.111831

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A Novel Polymer Nanoparticle Polydimethyl Diallyl Ammonium Chloride as An Adjuvant Enhances the Immune Response of SARS-CoV-2 Subunit Vaccine

Authors: Lili Ren, Chengcheng Ouyang, Shuqing Zhao, Qiqi Zheng, Weilu Guo, Baochao Fan, Jinzhu Zhou, Wei Zhang, Mi Hu, Jizong Li, Bin Li

Journal: Adv Healthc Mater

PubMed ID: 38436662

Doi: 10.1002/adhm.202304575

Products & Services: Protein and Antibody Isolation

Hepcidin contributes to largemouth bass (Micropterus salmoides) against bacterial infections

Authors: Weixiang Zhang, Bo Li, Ruying Yu, Wenyan Xu, Xiaoling Liu, Jianguo Su, Gailing Yuan

Journal: Int J Biol Macromol

PubMed ID: 38556234

Doi: 10.1016/j.ijbiomac.2024.131144

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Expression, purification, and biological activity evaluation of cathepsin L in mammalian cells

Authors: Wenwen Zhou, Baoqing You, Yifan Zheng, Shuyi Si, Yan Li, Jing Zhang

Journal: Biosci Biotechnol Biochem

PubMed ID: 38271604

Doi: 10.1093/bbb/zbae005

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Activation of Piezo1 increases the sensitivity of breast cancer to hyperthermia therapy

Authors: Shao-Kang Wang, Xiao-Ting Zhang, Xuan-Yao Jiang, Bi-Jiang Geng, Tao-Lin Qing, Lei Li, Yun Chen, Jin-Feng Li, Xiao-Fang Zhang, Shuo-Gui Xu, Jiang-Bo Zhu, Yu-Ping Zhu, Mei-Tang Wang, Ji-Kuai Chen

Journal: Open Med (Wars)

PubMed ID: 38463518

Doi: 10.1515/med-2024-0898

Products & Services: Protein and Antibody Isolation

EGFR amplification and EGFRvIII predict and participate in TAT-Cx43266-283 antitumor response in preclinical glioblastoma models

Authors: Andrea Álvarez-Vázquez, Laura San-Segundo, Pilar Cerveró-García, Raquel Flores-Hernández, Claudia Ollauri-Ibáñez, Berta Segura-Collar, C G Hubert, Gillian Morrison, Steven M Pollard, Justin D Lathia, Pilar Sánchez-Gómez, Arantxa Tabernero

Journal: Neuro Oncol

PubMed ID: 38507464

Doi: 10.1093/neuonc/noae060

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Dual mechanisms contribute to enhanced voltage dependence of an electric fish potassium channel

Authors: Jelena Todorovic, Immani Swapna, Antonio Suma, Vincenzo Carnevale, Harold Zakon

Journal: Biophys J

PubMed ID: 38429925

Doi: 10.1016/j.bpj.2024.02.028

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Antigenicity, epitope mapping, and intracellular distribution of the NSP7α protein of porcine reproductive and respiratory syndrome virus

Authors: Tao Wang, Da-Song Xia, Xiao-Xiao Tian, Yong-Bo Yang, Tong-Qing An

Journal: Int J Biol Macromol

PubMed ID: 38493809

Doi: 10.1016/j.ijbiomac.2024.130944

Products & Services: Protein and Antibody Isolation

Engineering a Lactobacillus Lysine Riboswitch to Dynamically Control Metabolic Pathways for Lysine Production in

Authors: Qingwei Jiang, Feng Geng, Juan Shen, Ping Zhu, Zhaoxin Lu, Libang Zhou, Fengxia Lu

Journal: Microorganisms

PubMed ID: 38543657

Doi: 10.3390/microorganisms12030606

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Safety and Immunogenicity of a Messenger RNA-Based Cytomegalovirus Vaccine in Healthy Adults: Results From a Phase 1, Randomized, Clinical Trial

Authors: Carlos Fierro, Daniel Brune, Marian Shaw, Howard Schwartz, Conor Knightly, Jiang Lin, Andrea Carfi, Andrew Natenshon, Shiva Kalidindi, Caroline Reuter, Jacqueline Miller, Lori Panther

Journal: J Infect Dis

PubMed ID: 38478705

Doi: 10.1093/infdis/jiae114

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Rapid and Mechanically Robust Immobilization of Proteins on Silica Studied at the Single-Molecule Level by Force Spectroscopy and Verified at the Macroscopic Level

Authors: Xiaoxu Zhang, Yayan Xie, Duo Huang, Xiaozhong Zhang, Xiaoyu Tang, Long Chen, Shi-Zhong Luo, Jizhong Lou, Chengzhi He

Journal: ACS Appl Mater Interfaces

PubMed ID: 38520330

Doi: 10.1021/acsami.3c18699

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Boosting Vaccine Response in Autoimmune Rheumatic Disease Patients With Inadequate Seroconversion: An Analysis of the Immunogenicity of Vector-Based and Inactivated Vaccines

Authors: Anuroopa Vijayan, Aswathy Sukumaran, Sara Jones, Aby Paul, Sakir Ahmed, Pankti Mehta, Manju Mohanan, Santhosh Kumar, Sreekumar Easwaran, Padmanabha Shenoy

Journal: Cureus

PubMed ID: 38586774

Doi: 10.7759/cureus.55764

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The human microbiota is a beneficial reservoir for SARS-CoV-2 mutations

Authors: Birong Cao, Xiaoxi Wang, Wanchao Yin, Zhaobing Gao, Bingqing Xia

Journal: MBio

PubMed ID: 38530031

Doi: 10.1128/mbio.03187-23

Products & Services: Protein and Antibody Isolation

The protein methyltransferase TrSAM inhibits cellulase gene expression by interacting with the negative regulator ACE1 in Trichoderma reesei

Authors: Zhihua Zhu, Gen Zou, Shunxing Chai, Meili Xiao, Yinmei Wang, Pingping Wang, Zhihua Zhou

Journal: Commun Biol

PubMed ID: 38548869

Doi: 10.1038/s42003-024-06072-1

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Discordant Antigenic Properties of Soluble and Virion SARS-CoV-2 Spike Proteins

Authors: Sameer Kumar, Souradip Dasgupta, Mohammad M Sajadi, Greg A Snyder, Anthony L DeVico, Krishanu Ray

Journal: Viruses

PubMed ID: 38543772

Doi: 10.3390/v16030407

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Highly stable and immunogenic CMV T cell vaccine candidate developed using a synthetic MVA platform

Authors: Marcal Yll-Pico, Yoonsuh Park, Joy Martinez, Angelina Iniguez, Mindy Kha, Taehyun Kim, Leonard Medrano, Vu H Nguyen, Teodora Kaltcheva, Shannon Dempsey, Flavia Chiuppesi, Felix Wussow, Don J Diamond

Journal: npj Vaccines

PubMed ID: 38555379

Doi: 10.1038/s41541-024-00859-3

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Authors: Yun Bai, Guanghua Cui, Xiaoke Sun, Meiqi Wei, Yanying Liu, Jialu Guo, Yu Yang

Journal: DNA Cell Biol

PubMed ID: 38466955

Doi: 10.1089/dna.2023.0392

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Flublok Quadrivalent Vaccine Adjuvanted with R-DOTAP Elicits a Robust and Multifunctional CD4 T Cell Response That Is of Greater Magnitude and Functional Diversity Than Conventional Adjuvant Systems

Authors: Chantelle L White, Maryah A Glover, Siva K Gandhapudi, Katherine A Richards, Andrea J Sant

Journal: Vaccines (Basel)

PubMed ID: 38543915

Doi: 10.3390/vaccines12030281

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Application of Recombinant Lactic Acid Bacteria (LAB) Live Vector Oral Vaccine in the Prevention of F4+ Enterotoxigenic

Authors: Jiangxu Yu, Jiyang Fu, Hongshuo Liu, Chao Kang, Zesong Wang, Yancheng Jin, Shuxuan Wu, Tianzhi Li, Ruicheng Yang, Meilin Jin, Huanchun Chen, Xiangru Wang

Journal: Vaccines (Basel)

PubMed ID: 38543938

Doi: 10.3390/vaccines12030304

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Integrative analysis of metabolism subtypes and identification of prognostic metabolism-related genes for glioblastoma

Authors: Jiahui Li, Yutian Wei, Jiali Liu, Shupeng Cheng, Xia Zhang, Huaide Qiu, Jianan Li, Chuan He

Journal: Biosci Rep

PubMed ID: 38419527

Doi: 10.1042/BSR20231400

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Development and Evaluation of an Immunoinformatics-Based Multi-Peptide Vaccine against Infection

Authors: Sean Jeffreys, Megan P Tompkins, Jadelynn Aki, Sara B Papp, James P Chambers, M Neal Guentzel, Chiung-Yu Hung, Jieh-Juen Yu, Bernard P Arulanandam

Journal: Vaccines (Basel)

PubMed ID: 38675740

Doi: 10.3390/vaccines12040358

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