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Characterization of genital chlamydia trachomatis infection among women attending infertility and gynecology clinics in Hunan, China

Authors: Qianting Zhou, Jiayan Li, Lipei Luo, Shuling Min, Li Wang, Lixiu Peng, Yinglan Hou, Ping He, Song He, Shixing Tang, Hongliang Chen

Journal: BMC Infect Dis

PubMed ID: 38622501

Doi: 10.1186/s12879-024-09254-8

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Development and performance evaluation of a novel elastic bacterial nanocellulose/polyurethane small caliber artificial blood vessels

Authors: Geli Li, Luhan Bao, Gaoquan Hu, Lin Chen, Xingping Zhou, Feng F Hong

Journal: Int J Biol Macromol

PubMed ID: 38641268

Doi: 10.1016/j.ijbiomac.2024.131685

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Enhancement of SARS-CoV-2 mRNA Vaccine Efficacy through the Application of TMSB10 UTR for Superior Antigen Presentation and Immune Activation

Authors: Xiaoyan Ding, Yuxin Zhou, Jiuxiang He, Jing Zhao, Jintao Li

Journal: Vaccines (Basel)

PubMed ID: 38675814

Doi: 10.3390/vaccines12040432

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Structure and dynamics of a pentameric KCTD5/CUL3/Gβγ E3 ubiquitin ligase complex

Authors: Duc Minh Nguyen, Deanna H Rath, Dominic Devost, Darlaine Pétrin, Robert Rizk, Alan X Ji, Naveen Narayanan, Darren Yong, Andrew Zhai, Douglas A Kuntz, Maha U Q Mian, Neil C Pomroy, Alexander F A Keszei, Samir Benlekbir, Mohammad T Mazhab-Jafari, John L Rubinstein, Terence E Hébert, Gilbert G Privé

Journal: Proc Natl Acad Sci U S A

PubMed ID: 38625940

Doi: 10.1073/pnas.2315018121

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Transcriptome analysis reveals the mechanism of antifungal peptide epinecidin-1 against Botrytis cinerea by mitochondrial dysfunction and oxidative stress

Authors: Li Fan, Yingying Wei, Yi Chen, Meriem Ouaziz, Shu Jiang, Feng Xu, Hongfei Wang, Xingfeng Shao

Journal: Pestic Biochem Physiol

PubMed ID: 38879298

Doi: 10.1016/j.pestbp.2024.105932

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Efficient gene knockout and genetic interaction screening using the in4mer CRISPR/Cas12a multiplex knockout platform

Authors: Nazanin Esmaeili Anvar, Chenchu Lin, Xingdi Ma, Lori L Wilson, Ryan Steger, Annabel K Sangree, Medina Colic, Sidney H Wang, John G Doench, Traver Hart

Journal: Nat Commun

PubMed ID: 38678031

Doi: 10.1038/s41467-024-47795-3

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Antisense oligonucleotide therapeutic approach for Timothy syndrome

Authors: Xiaoyu Chen, Fikri Birey,John Huguenard, Sergiu P Pașca

Journal: Nature

PubMed ID: 38658687

Doi: 10.1038/s41586-024-07310-6

Structural basis for human Cav3.2 inhibition by selective antagonists

Authors: Jian Huang, Xiao Fan, Xueqin Jin, Chen Lyu, Qinmeng Guo, Tao Liu, Jiaofeng Chen, Amaël Davakan, Philippe Lory, Nieng Yan

Journal: Cell Research

PubMed ID: 38605177

Doi: 10.1038/s41422-024-00959-8

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A gut microbiota-bile acid axis promotes intestinal homeostasis upon aspirin-mediated damage

Authors: Ting Li, Ning Ding, Hanqing Guo, Rui Hua, Zehao Lin, Huohuan Tian, Yue Yu, Daiming Fan, Zuyi Yuan, Frank J Gonzalez, Yue Wu

Journal: Cell Host & Microbe

PubMed ID: 38237593

Doi: 10.1016/j.chom.2023.12.015

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A folate inhibitor exploits metabolic differences in Pseudomonas aeruginosa for narrow-spectrum targeting

Authors: Connor Chain, Joseph P Sheehan, Xincheng Xu, Soodabeh Ghaffari, Aneesh Godbole, Hahn Kim, Joel S Freundlich, Joshua D Rabinowitz, Zemer Gitai

Journal: Nature Microbiology

PubMed ID: 38594311

Doi: 10.1038/s41564-024-01665-2

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Comparison of antibody-based immunotherapeutics for malignant hematological disease in an experimental murine model

Authors: Karin Frebel, Jörn C Albring, Anika Wohlgemuth, Christian Schwöppe, Stephan Hailfinger, Georg Lenz, Matthias Stelljes

Journal: Blood

PubMed ID: 38197968

Doi: 10.1182/bloodadvances.2023011647

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A hemoprotein with a zinc-mirror heme site ties heme availability to carbon metabolism in cyanobacteria

Authors: Nicolas Grosjean, Estella F Yee, Desigan Kumaran, Kriti Chopra, Macon Abernathy, Sandeep Biswas, James Byrnes, Dale F Kreitler, Jan-Fang Cheng, Agnidipta Ghosh, Steven C Almo, Masakazu Iwai, Krishna K Niyogi, Himadri B Pakrasi, Ritimukta Sarangi, Hubertus van Dam, Lin Yang, Ian K Blaby, Crysten E Blaby-Haas

Journal: Nature Communications

PubMed ID: 38609367

Doi: 10.1038/s41467-024-47486-z

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Targeting branched N-glycans and fucosylation sensitizes ovarian tumors to immune checkpoint blockade

Authors: Hao Nie, Pratima Saini, Taito Miyamoto, Liping Liao, Rafal J Zielinski, Heng Liu, Wei Zhou, Chen Wang, Brennah Murphy, Martina Towers, Tyler Yang, Yuan Qi, Toshitha Kannan, Andrew Kossenkov, Hiroaki Tateno, Daniel T Claiborne, Nan Zhang, Mohamed Abdel-Mohsen, Rugang Zhang

Journal: Nature Communications

PubMed ID: 38565883

Doi: 10.1038/s41467-024-47069-y

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Somatic and intergenerational G4C2 hexanucleotide repeat instability in a human C9orf72 knock-in mouse model

Authors: Nada Kojak, Junko Kuno, Kristina E Fittipaldi, Ambereen Khan, David Wenger, Michael Glasser, Roberto A Donnianni, Yajun Tang, Jade Zhang, Katie Huling, Roxanne Ally, Alejandro O Mujica, Terrence Turner, Gina Magardino, Pei Yi Huang, Sze Yen Kerk, Gustavo Droguett, Marine Prissette, Jose Rojas, Teodoro Gomez, Anthony Gagliardi, Charleen Hunt, Jeremy S Rabinowitz, Guochun Gong, William Poueymirou, Eric Chiao, Brian Zambrowicz, Chia-Jen Siao, Daisuke Kajimura

Journal: Nucleic Acids Res

PubMed ID: 38597682

Doi: 10.1093/nar/gkae250

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Human inherited PD-L1 deficiency is clinically and immunologically less severe than PD-1 deficiency

Authors: Matthew B Johnson, Masato Ogishi, Clara Domingo-Vila, Elisa De Franco, Matthew N Wakeling, Zineb Imane, Brittany Resnick, Evangelia Williams, Rui Pedro Galão, Richard Caswell, James Russ-Silsby, Yoann Seeleuthner , Darawan Rinchai, Iris Fagniez, Basilin Benson, Matthew J Dufort, Cate Speake , Megan E Smithmyer, Michelle Hudson, Rebecca Dobbs; EXE-T1D consortium; Zoe Quandt, Andrew T Hattersley ,Peng Zhang, Stephanie Boisson-Dupuis , Mark S Anderson, Jean-Laurent Casanova, Timothy I Tree, Richard A Oram

Journal: Journal Of Experimental Medicine

PubMed ID: 38634869

Doi: 10.1084/jem.20231704

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Deciphering S100B Allosteric Signaling: The Role of a Peptide Target, TRTK-12, as an Ensemble Modulator

Authors: Riya Samanta, Xinhao Zhuang, Kristen M Varney, David J Weber, Silvina Matysiak

Journal: J Chem Inf Model

PubMed ID: 38605537

Doi: 10.1021/acs.jcim.4c00116

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Targeting the heparan sulfate-binding site of RAGE with monoclonal antibodies

Authors: Chihyean Ong, Miaomiao Li, Ding Xu

Journal: Glycobiology

PubMed ID: 38181393

Doi: 10.1093/glycob/cwae001

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A measles-vectored vaccine candidate expressing prefusion-stabilized SARS-CoV-2 spike protein brought to phase I/II clinical trials: protection of African green monkeys from COVID-19 disease

Authors: Sham Nambulli, Nicolas Escriou, Linda J Rennick, Matthew J Demers, Natasha L Tilston-Lunel, Anita K McElroy, Dominique J Barbeau, Nicholas A Crossland, Ryan M Hoehl, Sabrina Schrauf, Alexander G White, H Jacob Borish, Jaime A Tomko, Lonnie J Frye, Charles A Scanga, JoAnne L Flynn, Annette Martin, Christiane Gerke, Amy L Hartman, W Paul Duprex

Journal: J Virol

PubMed ID: 38563762

Doi: 10.1128/jvi.01762-23

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Reverse-Phase Protein Microarrays for Overexpressed Lysates Reveal a Novel Tyrosine Kinase

Authors: Batuhan Birol Keskin, Chien-Sheng Chen, Pei-Shan Tsai, Pin-Xian Du, John Harvey M Santos, Guan-Da Syu

Journal: Anal Chem

PubMed ID: 38683735

Doi: 10.1021/acs.analchem.4c00965

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Distinguishing individual photobodies using Oligopaints reveals thermo-sensitive and -insensitive phytochrome B condensation at distinct subnuclear locations

Authors: Juan Du, Keunhwa Kim, Meng Chen

Journal: Nat Commun

PubMed ID: 38684657

Doi: 10.1038/s41467-024-47789-1

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Functional and structural insights into activation of TRPV2 by weak acids

Authors: Ferdinand M Haug, Ruth A Pumroy, Akshay Sridhar, Sebastian Pantke, Florian Dimek, Tabea C Fricke, Axel Hage, Christine Herzog, Frank G Echtermeyer, Jeanne de la Roche, Adrian Koh, Abhay Kotecha, Rebecca J Howard, Erik Lindahl, Vera Moiseenkova-Bell, Andreas Leffler

Journal: EMBO J

PubMed ID: 38671253

Doi: 10.1038/s44318-024-00106-4

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MCT4 and CD147 colocalize with MMP14 in invadopodia and support matrix degradation and invasion by breast cancer cells

Authors: Signe Meng, Ester E Sørensen, Muthulakshmi Ponniah, Jeppe Thorlacius-Ussing, Roxane Crouigneau, Tanja Larsen, Magnus T Borre, Nicholas Willumsen, Mette Flinck, Stine F Pedersen

Journal: J Cell Sci

PubMed ID: 38661040

Doi: 10.1242/jcs.261608

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Blocking group 2 innate lymphoid cell activation and macrophage M2 polarization: potential therapeutic mechanisms in ovalbumin-induced allergic asthma by calycosin

Authors: Chunyan Tian, Qi Liu, Xiaoyu Zhang, Zhuying Li

Journal: BMC Pharmacol Toxicol

PubMed ID: 38650035

Doi: 10.1186/s40360-024-00751-9

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The grapevine miR827a regulates the synthesis of stilbenes by targeting VqMYB14 and gives rise to susceptibility in plant immunity

Authors: Yangyang Luo, Linxia Wang, Jie Zhu, Jingwen Tian, Lin You, Qin Luo, Jia Li, Qian Yao, Dong Duan

Journal: Theor Appl Genet

PubMed ID: 38582777

Doi: 10.1007/s00122-024-04599-9

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Intestinal MAdCAM-1 imaging as biomarker for prognostic in murine models of multiple sclerosis

Authors: Erwan Baudron, Sara Martinez de Lizarrondo, Maxime Gauberti, Barbara Delaunay-Piednoir, Antoine P Fournier, Denis Vivien, Fabian Docagne, Isabelle Bardou

Journal: Brain Behav Immun

PubMed ID: 38604270

Doi: 10.1016/j.bbi.2024.04.006

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An improved system to generate recombinant canine distemper virus

Authors: Huai Cheng, Hewei Zhang, Huayun Zhang, Huanchang Cai, Min Liu, Mingen Yu, Meihua Xiang, Shubo Wen, Jingqiang Ren

Journal: BMC Vet Res

PubMed ID: 38678249

Doi: 10.1186/s12917-023-03830-x

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Catalytic specificity and crystal structure of cystathionine γ-lyase from Pseudomonas aeruginosa

Authors: Marco Pedretti, Carmen Fernández-Rodríguez, Carolina Conter, Iker Oyenarte, Filippo Favretto, Adele di Matteo, Paola Dominici, Maria Petrosino, Maria Luz Martinez-Chantar, Tomas Majtan, Alessandra Astegno, Luis Alfonso Martínez-Cruz

Journal: Sci Rep

PubMed ID: 38654065

Doi: 10.1038/s41598-024-57625-7

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A cAMP-biosensor-based assay for measuring plasma arginine-vasopressin levels

Authors: Kosuke Doi, Kouki Kawakami, Tatsuya Ikuta, Asuka Inoue

Journal: Sci Rep

PubMed ID: 38658606

Doi: 10.1038/s41598-024-60035-4

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Identification and structural characterization of small molecule inhibitors of PINK1

Authors: Shafqat Rasool, Tara Shomali, Luc Truong, Nathalie Croteau, Simon Veyron, Bernardo A Bustillos, Wolfdieter Springer, Fabienne C Fiesel, Jean-François Trempe

Journal: Sci Rep

PubMed ID: 38565869

Doi: 10.1038/s41598-024-58285-3

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Correlates of protection against symptomatic SARS-CoV-2 in vaccinated children

Authors: Youjia Zhong, Alicia Y H Kang, Carina J X Tay, Hui' En Li, Nurul Elyana, Chee Wah Tan, Wee Chee Yap, Joey M E Lim, Nina Le Bert, Kuan Rong Chan, Eugenia Z Ong, Jenny G Low, Lynette P Shek, Elizabeth Huiwen Tham, Eng Eong Ooi

Journal: Nat Med

PubMed ID: 38689059

Doi: 10.1038/s41591-024-02962-3

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Coordination of actin plus-end dynamics by IQGAP1, formin, and capping protein

Authors: Morgan L Pimm, Brian K Haarer, Alexander D Nobles, Laura M Haney, Alexandra G Marcin, Jessica L Henty-Ridilla

Journal: biorxiv

PubMed ID: 37205555

Doi: 10.1101/2023.05.04.539490

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Evolutionarily conserved ovarian fluid proteins are responsible for extending egg viability in salmonid fish

Authors: Aurélie Gueho, Daniel Żarski, Hélène Rime, Blandine Guével, Emmanuelle Com, Régis Lavigne, Thaovi Nguyen, Jérôme Montfort, Charles Pineau, Julien Bobe

Journal: Sci Rep

PubMed ID: 38671194

Doi: 10.1038/s41598-024-60118-2

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Cancer-associated polybromo-1 bromodomain 4 missense variants variably impact bromodomain ligand binding and cell growth suppression

Authors: Karina L. Bursch; Christopher J. Goetz; Guanming Jiao; Raymundo Nu ez; Michael D. Olp; Alisha Dhiman; Mallika Khurana; Michael T. Zimmermann; Raul A. Urrutia; Emily C. Dykhuizen; Brian C. Smith

Journal: The Journal of Biological Chemistry

PubMed ID: 38460939

Doi: 10.1016/j.jbc.2024.107146

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Graphene oxide films as a novel tool for the modulation of myeloid-derived suppressor cell activity in the context of multiple sclerosis

Authors: Celia Camacho-Toledano, Isabel Machín-Díaz, Rafael Lebrón-Galán, Ankor González-Mayorga, Francisco J Palomares, María C Serrano, Diego Clemente

Journal: Nanoscale

PubMed ID: 38498071

Doi: 10.1039/d3nr05351b

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Kalium channelrhodopsins effectively inhibit neurons

Authors: Stanislav Ott, Sangyu Xu, Nicole Lee, Ivan Hong, Jonathan Anns, Danesha Devini Suresh, Zhiyi Zhang, Xianyuan Zhang, Raihanah Harion, Weiying Ye, Vaishnavi Chandramouli, Suresh Jesuthasan, Yasunori Saheki, Adam Claridge-Chang

Journal: Nat Commun

PubMed ID: 38658537

Doi: 10.1038/s41467-024-47203-w

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RATA: A novel class A carbapenemase with broad geographic distribution and potential for global spread

Authors: Hongyan Luo, Zhishuang Yang, Ting Lei, Caixia Li, Zuoyong Zhou, Mingshu Wang, Dekang Zhu, Pei Li, Anchun Cheng

Journal: Sci Total Environ

PubMed ID: 38692330

Doi: 10.1016/j.scitotenv.2024.172873

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The SARS-CoV-2 Spike Protein Receptor-Binding Domain Expressed in Rice Callus Features a Homogeneous Mix of Complex-Type Glycans

Authors: Guillermo Sobrino-Mengual, Victoria Armario-Nájera, Juliette Balieu, Marie-Laure Walet-Balieu, Andrea Saba-Mayoral, Ana M Pelacho, Teresa Capell, Paul Christou, Muriel Bardor, Patrice Lerouge

Journal: Int J Mol Sci

PubMed ID: 38674051

Doi: 10.3390/ijms25084466

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Mutation of the peptide-regulated transcription factor ComR for amidated peptide specificity and heterologous function in WCFS1

Authors: Michael Brasino, Eli Wagnell, E Sila Ozdemir, Srivathsan Ranganathan, Justin Merritt

Journal: Microbiol Spectr

PubMed ID: 38687019

Doi: 10.1128/spectrum.00517-24

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Characterization of 35 novel NR5A1/SF-1 variants identified in individuals with atypical sexual development: The SF1next study

Authors: Rawda Naamneh Elzenaty, Idoia Martinez de Lapiscina, Chrysanthi Kouri, Kay-Sara Sauter, Grit Sommer, Luis Castaño, Christa E Flück

Journal: J Clin Endocrinol Metab

PubMed ID: 38623954

Doi: 10.1210/clinem/dgae251

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Development of a latex agglutination test based on VH antibody fragment for detection of Streptococcus suis serotype 2

Authors: Kiratika Chidkoksung, Nattihda Parakasikron, Suphachai Nuanualsuwan, Kannika Khantasup

Journal: PLoS ONE

PubMed ID: 38568909

Doi: 10.1371/journal.pone.0299691

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Identification and Quantification of a Pneumococcal Cell Wall Polysaccharide by Antibody-Enhanced Chromatography Assay

Authors: James Z Deng, Zhifeng Chen, James Small, Yue Yuan, Kara Cox, Aimin Tang, Jeanette Roman, Liming Guan, Katrina Feller, Frances Ansbro, Kalpit Vora

Journal: Vaccines (Basel)

PubMed ID: 38793720

Doi: 10.3390/vaccines12050469

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Selective Detection of Active Extracellular Granzyme A by Using a Novel Fluorescent Immunoprobe with Application to Inflammatory Diseases

Authors: Ana Senan-Salinas, Laura Comas, Patricia Esteban, Marcela Garzón-Tituaña, Zhiming Cheng, Llipsy Santiago, Maria Pilar Domingo, Ariel Ramírez-Labrada, José Ramón Paño-Pardo, Marc Vendrell, Julián Pardo, Maykel A Arias, Eva M Galvez

Journal: ACS Pharmacol Transl Sci

PubMed ID: 38751645

Doi: 10.1021/acsptsci.4c00065

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Antibacterial and Hemolytic Activity of Antimicrobial Hydrogels Utilizing Immobilized Antimicrobial Peptides

Authors: Edvin Blomstrand, Elin Posch, Annija Stepulane, Anand K Rajasekharan, Martin Andersson

Journal: Int J Mol Sci

PubMed ID: 38673786

Doi: 10.3390/ijms25084200

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Artemisinin Confers Cytoprotection toward Hydrogen Peroxide-Induced Cell Apoptosis in Retinal Pigment Epithelial Cells in Correlation with the Increased Acetylation of Histone H4 at Lysine 8

Authors: Chao Yang, Lijun Ge, Xiyong Yu, Philip Lazarovici, Wenhua Zheng

Journal: Molecules

PubMed ID: 38675608

Doi: 10.3390/molecules29081789

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Biophysical characterization and insights into the oligomeric nature of CD2-associated protein

Authors: Abrar H Qadri, Jyotsana Prajapati, Iqball Faheem, Utsa Bhattacharjee, Hari Krishnan Padmanaban, Sandeep Kn Mulukala, Anil K Pasupulati

Journal: Int J Biochem Mol Biol

PubMed ID: 38765876

Doi: 10.62347/UVSH8436

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Injectable self-assembled GDF5-containing dipeptide hydrogels for enhanced tendon repair

Authors: Ming Zhang, Hao Wang, Guan-Chun Dai, Pan-Pan Lu, Yu-Cheng Gao, Mu-Ming Cao, Ying-Juan Li, Yun-Feng Rui

Journal: Mater Today Bio

PubMed ID: 38600922

Doi: 10.1016/j.mtbio.2024.101046

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Higher correlation between neutralizing antibodies and surrogate neutralizing or binding antibodies in COVID-19 patients than vaccine recipients

Authors: Hatairat Lerdsamran, Ratikorn Anusorntanawat, Kantima Sangsiriwut, Suteema Sawadpongpan, Jarunee Prasertsopon, Nattakarn Thinpan, Poj Intalapaporn, Ranida Techasuwanna, Pilailuk Okada, Pilaipan Puthavathana

Journal: PLoS ONE

PubMed ID: 38626137

Doi: 10.1371/journal.pone.0298033

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Energy metabolism as therapeutic target for aged wound repair by engineered extracellular vesicle

Authors: Yu Zhuang , Shengjie Jiang , Xiaoling Deng , An Lao , Xiaolin Hua , Yun Xie , Lingyong Jiang , Xudong Wang , Kaili Lin

Journal: SCIENCE ADVANCES

PubMed ID: 38608014

Doi: 10.1126/sciadv.adl0372

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Metal-Binding Protein TaGlo1 Improves Fungal Resistance to Arsenite (As) and Methylarsenite (MAs) in Paddy Soil

Authors: Lijuan Li, Jian Tian, Ke Huang, Ximei Xue, Jian Chen, Feifei Guan, Tuo Zhang, Yifei Sun, Chao He, Xibai Zeng, Shiming Su

Journal: Environ Sci Technol

PubMed ID: 38557082

Doi: 10.1021/acs.est.3c11043

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Engineering, structure, and immunogenicity of a Crimean-Congo hemorrhagic fever virus pre-fusion heterotrimeric glycoprotein complex

Authors: Elizabeth McFadden, Stephanie R Monticelli, Albert Wang, Ajit R Ramamohan, Thomas G Batchelor, Ana I Kuehne, Russell R Bakken, Alexandra L Tse, Kartik Chandran, Andrew S Herbert, Jason S McLellan

Journal: biorxiv

PubMed ID: 38659837

Doi: 10.1101/2024.04.20.590419

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