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DOCK4 is a Novel Prognostic Biomarker and Correlated with Immune Infiltrates in Colon Adenocarcinoma

Authors: Xingjiang Xie, Yi Lu, Bo Wang, Xiaobin Yin, Jianfeng Chen

Journal: Comb Chem High Throughput Screen

PubMed ID: 37702239

Doi: 10.2174/1386207326666230912094101

Products & Services: Proteins, Expression, Isolation and Analysis

Cross-species immunoprotective antigens (subolesin, ferritin 2 and P0) provide protection against Rhipicephalus sanguineus sensu lato

Authors: Ismail Zeb, Luís Fernando Parizi, Muhammad Israr, Itabajara da Silva Vaz, Abid Ali

Journal: Parasit Vectors

PubMed ID: 38172894

Doi: 10.1186/s13071-023-06079-3

Products & Services: Proteins, Expression, Isolation and Analysis

Nanobodies as potential tools for microbiological testing of live biotherapeutic products

Authors: Robert J Dorosky, Jeremy E Schreier, Stephanie L Lola, Rosa L Sava, Michael P Coryell, Adovi Akue, Mark KuKuruga, Paul E Carlson, Sheila M Dreher-Lesnick, Scott Stibitz

Journal: AMB Express

PubMed ID: 38245586

Doi: 10.1186/s13568-023-01659-z

Products & Services: Custom Vector Construction

Oral delivery of bacteria expressing wsv108 gene-specific dsRNA protects shrimp from white spot syndrome virus (WSSV) infection

Authors: Linwei Yang, Siyou Huang, Zi-Ang Wang, Deyu Han, Yushi Gan, Ran Geng, Hongliang Zuo, Zhixun Guo, Shaoping Weng, Jianguo He, Xiaopeng Xu

Journal: Int J Biol Macromol

PubMed ID: 38302014

Doi: 10.1016/j.ijbiomac.2024.129840

Products & Services: Proteins, Expression, Isolation and Analysis

Deciphering the crystal structure of a novel nanobody against the NEIL1 DNA glycosylase

Authors: Marlo K Thompson, Nidhi Sharma, Andrea Thorn, Aishwarya Prakash

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 38289715

Doi: 10.1107/S205979832400038X

Products & Services: Molecular Biology Reagents

Longitudinal analysis of antibody responses to Plasmodium vivax sporozoite antigens following natural infection

Authors: Pongsakorn Thawornpan, Justin Nicholas, Chayapat Malee, Piyawan Kochayoo, Kittikorn Wangriatisak, Pachara Tianpothong, Francis Babila Ntumngia, Samantha J Barnes, John H Adams, Patchanee Chootong

Journal: PLoS Negl Trop Dis

PubMed ID: 38277340

Doi: 10.1371/journal.pntd.0011907

Products & Services: Molecular Biology Reagents

Identification and Functional Characterization of Oxidosqualene Cyclases from Medicinal Plant

Authors: Iffat Parveen, Mei Wang, Joseph Lee, Jianping Zhao, Yingjie Zhu, Amar G Chittiboyina, Ikhlas A Khan, Zhiqiang Pan

Journal: Plants (Basel)

PubMed ID: 38256784

Doi: 10.3390/plants13020231

Products & Services: ORF cDNA Clones/MolecularCloud

A dual-functional oncolytic adenovirus ZD55-aPD-L1 scFv armed with PD-L1 inhibitor potentiates its antitumor activity

Authors: Shengsheng Mei, Shanshan Peng, Eu Gene Vong, Jinbiao Zhan

Journal: Int Immunopharmacol

PubMed ID: 38278066

Doi: 10.1016/j.intimp.2024.111579

Products & Services: Recombinant Proteins

Mulberry-derived miR168a downregulates BmMthl1 to promote physical development and fecundity in silkworms

Authors: Lin Chen, Jiubo Liang, Qi Zhang, Chao Yang, Hulin Lu, Renze Zhang, Kaiying Chen, Sheng Wang, Mingbo Li, Shaoyu Zhang, Ningjia He

Journal: Int J Biol Macromol

PubMed ID: 38199542

Doi: 10.1016/j.ijbiomac.2023.129077

Products & Services: Catalog Antibody

A novel fully human anti-NT-ANGPTL3 antibody from phage display library exhibits potent ApoB, TG, and LDL-C lowering activities in hyperlipidemia mice

Authors: Panpan Zhang, Ke Wang, Tuo Hu, Menglong Xu, Xiangyan You, Manman Chen, Xuan Tang, Huajing Hu, Yiwei Jiang, Wenfeng Zhao, Shuhua Tan

Journal: FASEB J

PubMed ID: 38174870

Doi: 10.1096/fj.202301564RR

Products & Services: Molecular Biology Reagents

Individual transmembrane domains of SfABCC2 from Spodoptera frugiperda do not serve as functional Cry1F receptors

Authors: Jianfeng Zhong, Rafael Ferreira Dos Santos, Heba Abdelgaffar, Caroline Placidi de Bortoli, Ahmad Raza, Juan Luis Jurat-Fuentes

Journal: Pestic Biochem Physiol

PubMed ID: 38458684

Doi: 10.1016/j.pestbp.2024.105777

Products & Services: Proteins, Expression, Isolation and Analysis

Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23

Authors: Yehudi Bloch, Jan Felix, Romain Merceron, Mathias Provost, Royan Alipour Symakani, Robin De Backer, Elisabeth Lambert, Ahmad R Mehdipour, Savvas N Savvides

Journal: Nat Struct Mol Biol

PubMed ID: 38287195

Doi: 10.1038/s41594-023-01190-6

Products & Services: Gene Synthesis

Temporal dynamics of the early immune response following Mycobacterium bovis infection of cattle

Authors: Thomas Holder, Sreenidhi Srinivasan, Adrian McGoldrick, Gareth A Williams, Simonette Palmer, John Clarke, Amanda O'Brien, Andrew J K Conlan, Nick Juleff, H Martin Vordermeier, Gareth J Jones, Vivek Kapur

Journal: Sci Rep

PubMed ID: 38297023

Doi: 10.1038/s41598-024-52314-x

Products & Services: Catalog Peptides

Multivalent Calixarene Complexation of a Designed Pentameric Lectin

Authors: Ronan J Flood, Linda Cerofolini, Marco Fragai, Peter B Crowley

Journal: Biomacromolecules

PubMed ID: 38227741

Doi: 10.1021/acs.biomac.3c01280

Products & Services: Molecular Biology Reagents

Design of protein-binding peptides with controlled binding affinity: the case of SARS-CoV-2 receptor binding domain and angiotensin-converting enzyme 2 derived peptides

Authors: Giacomo Parisi, Roberta Piacentini, Alessio Incocciati, Alessandra Bonamore, Alberto Macone, Jakob Rupert, Elsa Zacco, Mattia Miotto, Edoardo Milanetti, Gian Gaetano Tartaglia, Giancarlo Ruocco, Alberto Boffi, Lorenzo Di Rienzo

Journal: Front Mol Biosci

PubMed ID: 38250735

Doi: 10.3389/fmolb.2023.1332359

Products & Services: Recombinant Proteins

Proteome profiling of enriched membrane-associated proteins unraveled a novel sophorose and cello-oligosaccharide transporter in Trichoderma reesei

Authors: Karoline Maria Vieira Nogueira, Vanessa Mendes, Karthik Shantharam Kamath, Anusha Cheruku, Letícia Harumi Oshiquiri, Renato Graciano de Paula, Claudia Carraro, Wellington Ramos Pedersoli, Lucas Matheus Soares Pereira, Luiz Carlos Vieira, Andrei Stecca Steindorff, Ardeshir Amirkhani, Matthew J McKay, Helena Nevalainen, Mark P Molloy, Roberto N Silva

Journal: Microb Cell Fact

PubMed ID: 38229067

Doi: 10.1186/s12934-023-02279-9

Products & Services: Gene Synthesis

Improved Solubility and Stability of a Thermostable Carbonic Anhydrase via Fusion with Marine-Derived Intrinsically Disordered Solubility Enhancers

Authors:

Journal: Int J Mol Sci

PubMed ID: 38256209

Doi: 10.3390/ijms25021139

Products & Services: Molecular Biology Reagents

ADORA2B, transcriptionally suppressing by MYC, promotes ferroptosis of chondrocytes via inhibition of the PI3K/Akt pathway in mice with osteoarthritis

Authors: Shen Li, Jiangbo Han, Jiongzhe Cao, Hong Han, Bin Lu, Tao Wen, Weiguo Bian

Journal: Environ Toxicol

PubMed ID: 38174997

Doi: 10.1002/tox.24131

Products & Services: Catalog Peptides

High-titer manufacturing of SARS-CoV-2 Spike-pseudotyped VSV in stirred-tank bioreactors

Authors: Hayley M Todesco, Chris Gafuik, Cini M John, Erin L Roberts, Breanna S Borys, Alexis Pawluk, Michael S Kallos, Kyle G Potts, Douglas J Mahoney

Journal: Mol Ther Methods Clin Dev

PubMed ID: 38327804

Doi: 10.1016/j.omtm.2024.101189

Dual-specificity phosphatase 1 interacts with prohibitin 2 to improve mitochondrial quality control against type-3 cardiorenal syndrome

Authors: Nanyang Liu, Yanqiu Ding, Hao Zhou, Xing Chang, Long Lou

Journal: Int J Med Sci

PubMed ID: 38322592

Doi: 10.7150/ijms.90484

Products & Services: Proteins, Expression, Isolation and Analysis

Targeted mutagenesis in mice via an engineered AsCas12f1 system

Authors: Peng Fan, Hejun Wang, Feiyu Zhao, Tao Zhang, Jinze Li, Xiaodi Sun, Yongduo Yu, Haoyang Xiong, Liangxue Lai, Tingting Sui

Journal: Cell Mol Life Sci

PubMed ID: 38280977

Doi: 10.1007/s00018-023-05100-3

Products & Services: Molecular Biology Reagents

TLR4 Ligands in Typhoid Vi Polysaccharide Subunit Vaccines Contribute to Immunogenicity

Authors:

Journal: Immunohorizons

PubMed ID: 38180344

Doi: 10.4049/immunohorizons.2300085

Products & Services: Molecular Biology Reagents

A feedback loop that drives cell death and proliferation and its defect in intestinal stem cells

Authors: Shivakshi Sulekh, Yuko Ikegawa, Saki Naito, Asami Oji, Ichiro Hiratani, Sa Kan Yoo

Journal: Life Sci Alliance

PubMed ID: 38296349

Doi: 10.26508/lsa.202302238

Products & Services: Gene Synthesis

Clinical assays rapidly predict bacterial susceptibility to monoclonal antibody therapy

Authors: Matthew J Slarve, Neven Bowler, Elizabeth Burk, Jun Yan, Ulrike Carlino-MacDonald, Thomas A Russo, Brian M Luna, Brad Spellberg

Journal: JCI Insight

PubMed ID: 38258902

Doi: 10.1172/jci.insight.174799

Products & Services: Gene Synthesis

B-Type Natriuretic Peptide Inhibits the Expression and Function of SERCA2a in Heart Failure

Authors: Yuting Zhai, Junhong Chen, Rongsheng Kan, Haochen Xuan, Chaofan Wang, Dongye Li, Tongda Xu

Journal: Int Heart J

PubMed ID: 38556337

Doi: 10.1536/ihj.23-144

Products & Services: Molecular Biology Reagents

Recombinant protein expression in proteome-reduced cells under aerobic and oxygen-limited regimes

Authors: Alvaro R Lara, Jose Utrilla, Luz María Martínez, Niels Krausch, Lucas Kaspersetz, David Hidalgo, Nicolas Cruz-Bournazou, Peter Neubauer, Juan-Carlos Sigala, Guillermo Gosset, Jochen Büchs

Journal: Biotechnol Bioeng

PubMed ID: 38178599

Doi: 10.1002/bit.28645

Products & Services: Molecular Biology Reagents

Guiding bar motif of thioredoxin reductase 1 modulates enzymatic activity and inhibitor binding by communicating with the co-factor FAD and regulating the flexible C-terminal redox motif

Authors: Wuyang Shi , Shibo Sun , Haowen Liu , Yao Meng , Kangshuai Ren , Guoying Wang , Minghui Liu , Jiaqi Wu , Yue Zhang , Huang Huang , Meiyun Shi , Weiping Xu , Qiang Ma , Bingbing Sun , Jianqiang Xu

Journal: Redox biology

Doi: 10.1016/j.redox.2024.103050

Products & Services: Proteins, Expression, Isolation and Analysis

Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules

Authors: Christopher M. Hickey, Katherine M. Digianantonio, Kurt Zimmermann , Alicia Harbin, Connor Quinn, Avani Patel, Peter Gareiss , Amanda Chapman1 , Bernadette Tiberi1,2, Jennifer Dobrodziej1,3, John Corradi1 , Angela M. Cacace1 , David R. Langley & Miklós Békés

Journal: NATURE STRUCTURAL & MOLECULAR BIOLOGY

Doi: 10.1038/s41594-023-01146-w

Products & Services: Peptide Synthesis Gene Synthesis

Influenza a Neuraminidase-Based Bivalent mRNA Vaccine Induces Th1-Type Immune Response and Provides Protective Effects in Mice

Authors: Mingyang Li , Mengyuan Liu , Shaohui Song, Ruirui Zhao, Yun Xie, Jing Liu, Lilan Xu, Xuefeng Ma, Mingyu Song, Jian Zhou and Guoyang Liao

Journal: vaccine

Doi: 10.3390/vaccines12030300

Products & Services: Gene Synthesis

The structure of the diheme cytochrome c from Neisseria gonorrhoeae reveals multiple contributors to tuning reduction potentials

Authors: Fangfang Zhong, Morgan E Reik, Michael J Ragusa, Ekaterina V Pletneva

Journal: J Inorg Biochem

PubMed ID: 38330683

Doi: 10.1016/j.jinorgbio.2024.112496

Products & Services: Molecular Biology Reagents

Three immunizations with Novavax's protein vaccines increase antibody breadth and provide durable protection from SARS-CoV-2

Authors: Klara Lenart, Rodrigo Arcoverde Cerveira, Fredrika Hellgren, Sebastian Ols, Daniel J Sheward, Changil Kim, Alberto Cagigi, Matthew Gagne, Brandon Davis, Daritza Germosen, Vicky Roy, Galit Alter, Hélène Letscher, Jérôme Van Wassenhove, Wesley Gros, Anne-Sophie Gallouët, Roger Le Grand, Harry Kleanthous, Mimi Guebre-Xabier, Ben Murrell, Nita Patel, Gregory Glenn, Gale Smith, Karin Loré

Journal: npj Vaccines

PubMed ID: 38245545

Doi: 10.1038/s41541-024-00806-2

Products & Services: Recombinant Proteins

Systematic analysis of the prognostic value and immunological function of LTBR in human cancer

Authors: Yinteng Wu, Shijian Zhao, Wenliang Guo, Ying Liu, Marìa Del Mar Requena Mullor, Raquel Alarcòn Rodrìguez, Ruqiong Wei

Journal: Aging (Albany NY)

PubMed ID: 38175686

Doi: 10.18632/aging.205356

Products & Services: Molecular Biology Reagents

A lncRNA Dleu2-encoded peptide relieves autoimmunity by facilitating Smad3-mediated Treg induction

Authors: Sibei Tang, Junxun Zhang, Fangzhou Lou, Hong Zhou, Xiaojie Cai, Zhikai Wang, Libo Sun, Yang Sun, Xiangxiao Li, Li Fan, Yan Li, Xinping Jin, Siyu Deng, Qianqian Yin, Jing Bai, Hong Wang, Honglin Wang

Journal: EMBO Rep

PubMed ID: 38291338

Doi: 10.1038/s44319-024-00070-4

Products & Services: Peptide Synthesis

Complete microbial synthesis of crocetin and crocins from glycerol in Escherichia coli

Authors: Jun Ho Lee, Seong-Rae Lee, Sang Yup Lee, Pyung Cheon Lee

Journal: Microb Cell Fact

PubMed ID: 38178149

Doi: 10.1186/s12934-023-02287-9

Products & Services: PCR Cloning and Subcloning

Structural and functional properties of uridine 5'-monophosphate synthase from Coffea arabica

Authors: Alexis Hinojosa-Cruz, Ángel G Díaz-Sánchez, Adelaida Díaz-Vilchis, Lilian González-Segura

Journal: Int J Biol Macromol

PubMed ID: 38184030

Doi: 10.1016/j.ijbiomac.2024.129226

Products & Services: Molecular Biology Reagents

Circ_0007422 Knockdown Inhibits Tumor Property and Immune Escape of Colorectal Cancer by Decreasing PDL1 Expression in a miR-1256-Dependent Manner

Authors: Dian Yin, Li Yang, Xiu Feng, Xiaolu Zhai, Mei Hua, Jing Liu, Ying Chen

Journal: Mol Biotechnol

PubMed ID: 38253900

Doi: 10.1007/s12033-023-01040-2

Products & Services: Mutant Libraries

Mitochondrial stress activates YAP/TAZ through RhoA oxidation to promote liver injury

Authors: Ari Kwon, Na Young Lee, Jae-Hyun Yu, Myeung Gi Choi, Jeongwoo Park, Ja Hyun Koo

Journal: Cell Death Dis

PubMed ID: 38225223

Doi: 10.1038/s41419-024-06448-5

Products & Services: Proteins, Expression, Isolation and Analysis

PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation

Authors: Christopher Chin Sang, Gaelen Moore, Maria Tereshchenko, Michael L Nosella, Hongshan Zhang, T Reid Alderson, Morgan Dasovich, Anthony Leung, Ilya J Finkelstein, Julie D Forman-Kay, Hyun O Lee

Journal: biorxiv

PubMed ID: 38328070

Doi: 10.1101/2024.01.20.575817

Products & Services: Gene Synthesis

CFL1 restores the migratory capacity of bone marrow mesenchymal stem cells in primary Sjögren's syndrome by regulating CCR1 expression

Authors: Mengxi Huang, Panpan Zhou, Yang Hang, Dan Wu, Nan Zhao, Genhong Yao, Xiaojun Tang, Lingyun Sun

Journal: Int Immunopharmacol

PubMed ID: 38183912

Doi: 10.1016/j.intimp.2024.111485

Products & Services: Molecular Biology Reagents

A novel opsonic eCIRP inhibitor for lethal sepsis

Authors: Colleen P Nofi, Chuyi Tan, Gaifeng Ma, Molly Kobritz, Jose M Prince, Haichao Wang, Monowar Aziz, Ping Wang

Journal: J Leukoc Biol

PubMed ID: 37774691

Doi: 10.1093/jleuko/qiad119

Products & Services: Catalog Peptides

Glucose 6-phosphate dehydrogenase variants increase NADPH pools for yeast isoprenoid production

Authors: Sri Harsha Adusumilli, Anuthariq Alikkam Veetil, Chinmayee Choudhury, Banani Chattopadhyaya, Diptimayee Behera, Anand Kumar Bachhawat

Journal: FEBS Open Bio

PubMed ID: 38124687

Doi: 10.1002/2211-5463.13755

Products & Services: Molecular Biology Reagents

The CRISPR effector Cam1 mediates membrane depolarization for phage defence

Authors: Christian F. Baca, You Yu, Jakob T. Rostøl, Puja Majumder, Dinshaw J. Patel & Luciano A. Marraffini

Journal: Nature

PubMed ID: 38200316

Doi: 10.1038/s41586-023-06902-y

Products & Services: GenCrispr Cas9 Genome Editing

Terminal modifications independent cell-free RNA sequencing enables sensitive early cancer detection and classification

Authors: Jun Wang , Jinyong Huang , Yunlong Hu , Qianwen Guo , Shasha Zhang , Jinglin Tian , Yanqin Niu , Ling Ji , Yuzhong Xu , Peijun Tang , Yaqin He , Yuna Wang , Shuya Zhang , Hao Yang , Kang Kang , Xinchun Chen , Xinying Li , Ming Yang , Deming Gou

Journal: Nat Commun

PubMed ID: 38168054

Doi: 10.1038/s41467-023-44461-y

Products & Services: Gene Synthesis

Profiling the Plasmodium falciparum Erythrocyte Membrane Protein 1-Specific Immununoglobulin G Response Among Ghanaian Children With Hemoglobin S and C

Authors: Andrew V Oleinikov, Zakaria Seidu, Irina V Oleinikov, Mary Tetteh, Helena Lamptey, Michael F Ofori, Lars Hviid, Mary Lopez-Perez

Journal: J Infect Dis

PubMed ID: 37804095

Doi: 10.1093/infdis/jiad438

Products & Services: Proteins, Expression, Isolation and Analysis

Cdk5-dependent rapid formation and stabilization of dendritic spines by corticotropin-releasing factor

Authors: Dorien Vandael, Katlijn Vints, Pieter Baatsen, Małgorzata A Śliwińska, Sergio Gabarre, Lies De Groef, Lieve Moons, Vasily Rybakin, Natalia V Gounko

Journal: Transl Psychiatry

PubMed ID: 38233378

Doi: 10.1038/s41398-024-02749-7

Enhancing Oral Delivery of Biologics: A Non-Competitive and Cross-Reactive Anti-Leptin Receptor Nanofitin Demonstrates a Gut-Crossing Capacity in an Ex Vivo Porcine Intestinal Model

Authors: Solene Masloh, Anne Chevrel, Maxime Culot, Anaëlle Perrocheau, Yogeshvar N Kalia, Samuel Frehel, Rémi Gaussin, Fabien Gosselet, Simon Huet, Magali Zeisser Labouebe, Leonardo Scapozza

Journal: Pharmaceutics

PubMed ID: 38258126

Doi: 10.3390/pharmaceutics16010116

Products & Services: Gene Synthesis

Restricted Omicron-specific cross-variant memory B-cell immunity after a 3rd dose/booster of monovalent Wuhan-Hu-1-containing COVID-19 mRNA vaccine

Authors: Iana H Haralambieva, Jonathon M Monroe, Inna G Ovsyannikova, Nathaniel D Warner, Diane E Grill, Gregory A Poland, Richard B Kennedy

Journal: Vaccine

PubMed ID: 38233288

Doi: 10.1016/j.vaccine.2024.01.032

Products & Services: Recombinant Proteins

Phylogenetic conservation of Trop-2 across species-rodent and primate genomics model anti-Trop-2 therapy for pre-clinical benchmarks

Authors: Emanuela Guerra, Marco Trerotola, Valeria Relli, Rossano Lattanzio, Khouloud Boujnah, Nicole Travali, Antonino Moschella, Paolo Todaro, Laura Pierdomenico, Roberta Di Pietro, Nicola Tinari, Saverio Alberti

Journal: Front Genet

PubMed ID: 38250577

Doi: 10.3389/fgene.2023.1297367

Products & Services: Gene Synthesis

Construction and characterization of a humanized rat model with its application in evaluating the uptake of different statins

Authors: Yuanjin Zhang, Junze Huang, Shengbo Huang, Jie Liu, Luyao Deng, Chenmeizi Liang, Yuanqing Guo, Bingyi Yao, Xin Wang

Journal: Acta Pharm Sin B

PubMed ID: 38572097

Doi: 10.1016/j.apsb.2023.12.019

Products & Services: Gene Synthesis

LINC00662 promotes melanoma progression by competitively binding miR-107 and activating the β-catenin signaling pathway

Authors: Mengmeng Luo, Rui Lei, Qingfang Zhao, Yichen Shen, Zhigang He, Jinghong Xu

Journal: Int J Med Sci

PubMed ID: 38169586

Doi: 10.7150/ijms.84072

Products & Services: Molecular Biology Reagents