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Buffer choice and pH strongly influence phase separation of SARS-CoV-2 nucleocapsid with RNA

Authors: Nina C Kathe, Mihajlo Novakovic, Frédéric H-T Allain

Journal: Mol Biol Cell

PubMed ID: 38568799

Doi: 10.1091/mbc.E23-12-0500

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Epitope mapping and a candidate vaccine design from canine distemper virus

Authors: Camila Pereira Dos Santos, Jerlane Tarcilia Gomes Telles, Georgia de Freitas Guimarães, Laura Helena Vega Gonzales Gil, Amanda Mota Vieira, Jose Wilton Pinheiro Junior, Carlos Eduardo Calzavara-Silva, Rita de Cássia CarvalhoMaia

Journal: Open Vet J

PubMed ID: 38808294

Doi: 10.5455/OVJ.2024.v14.i4.9

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Analysis of the Immunogenicity of African Swine Fever F317L Protein and Screening of T Cell Epitopes

Authors: Ying Huang, Wenzhu Zhai, Zhen Wang, Yuheng He, Chunhao Tao, Yuanyuan Chu, Zhongbao Pang, Hongfei Zhu, Hong Jia

Journal: Animals (Basel)

PubMed ID: 38731330

Doi: 10.3390/ani14091331

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FOXO1 is a master regulator of memory programming in CAR T cells

Authors: Alexander E Doan, Katherine P Mueller, Andy Y Chen, Geoffrey T Rouin, Yingshi Chen, Bence Daniel, John Lattin, Martina Markovska, Brett Mozarsky, Jose Arias-Umana, Robert Hapke, In-Young Jung, Alice Wang, Peng Xu, Dorota Klysz, Gabrielle Zuern, Malek Bashti, Patrick J Quinn, Zhuang Miao, Katalin Sandor, Wenxi Zhang, Gregory M Chen, Faith Ryu, Meghan Logun, Junior Hall, Kai Tan, Stephan A Grupp, Susan E McClory, Caleb A Lareau, Joseph A Fraietta, Elena Sotillo, Ansuman T Satpathy, Crystal L Mackall, Evan W Weber

Journal: Nature

PubMed ID: 38600391

Doi: 10.1038/s41586-024-07300-8

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AKAP3-mediated type I PKA signaling is required for mouse sperm hyperactivation and fertility†

Authors: Zhongkun Liang, Chaowei Dai, Fenfen He, Yu Wang, Yihua Huang, Heying Li, Yongming Wu, Yafang Hu, Kaibiao Xu

Journal: Biol Reprod

PubMed ID: 38145487

Doi: 10.1093/biolre/ioad180

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Lysin and Lytic Phages Reduce Vibrio Counts in Live Feed and Fish Larvae

Authors: Jaime Romero, Sergueia Blas-Chumacero, Victoria Urzúa, Alejandro Villasante, Rafael Opazo, Felipe Gajardo, Claudio D Miranda, Rodrigo Rojas

Journal: Microorganisms

PubMed ID: 38792735

Doi: 10.3390/microorganisms12050904

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BRD2-specific inhibitor, BBC0403, inhibits the progression of osteoarthritis pathogenesis in osteoarthritis-induced C57BL/6 male mice

Authors: Hyemi Lee, Jiho Nam, Hahyeong Jang, Young-Sik Park, Min-Hee Son, In-Hyun Lee, Seong-Il Eyun, Jae-Hyun Yang, Jimin Jeon, Siyoung Yang

Journal: Br J Pharmacol

PubMed ID: 38600628

Doi: 10.1111/bph.16359

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Structural basis for the minimal bifunctional alginate epimerase AlgE3 from Azotobacter chroococcum

Authors: Takaaki Fujiwara, Eriko Mano, Eriko Nango

Journal: FEBS Lett

PubMed ID: 38649293

Doi: 10.1002/1873-3468.14886

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The hsa_circ_0082152 maintains NF-κB mRNA stability by binding to MTDH to promote anti-tuberculosis drug-induced liver injury

Authors: Lin Wang, Chunyan Meng, Yifei Long, Yue Liu, Luming Yang, Xuelei Gao, Shufeng Sun, Fumin Feng

Journal: Int J Biol Macromol

PubMed ID: 38670193

Doi: 10.1016/j.ijbiomac.2024.131793

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LncRNA BlncAD1 Modulates Bovine Adipogenesis by Binding to MYH10, PI3K/Akt Signaling Pathway, and miR-27a-5p/CDK6 Axis

Authors: Xin Li, Zhongyi Hou, Shengbo Meng, Qihui Jia, Shanshan Xing, Zhitong Wang, Mengjuan Chen, Huifen Xu, Ming Li, Hanfang Cai

Journal: J Agric Food Chem

PubMed ID: 38661523

Doi: 10.1021/acs.jafc.4c00165

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The Ser/Thr protein kinase FonKin4-poly(ADP-ribose) polymerase FonPARP1 phosphorylation cascade is required for the pathogenicity of watermelon fusarium wilt fungus f sp

Authors: Jiajing Wang, Yizhou Gao, Xiaohui Xiong, Yuqing Yan, Jiajun Lou, Muhammad Noman, Dayong Li, Fengming Song

Journal: Front Microbiol

PubMed ID: 38690366

Doi: 10.3389/fmicb.2024.1397688

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Development of a novel monoclonal antibody-based competitive ELISA for antibody detection against bovine leukemia virus

Authors: Jing Wang, Chao Sun, Zhe Hu, Fang Wang, Jitao Chang, Ming Gao, Dandan Ye, Qi Jia, Hui Zou, Luc Willems, Zhigang Jiang, Xin Yin

Journal: Int J Biol Macromol

PubMed ID: 38621561

Doi: 10.1016/j.ijbiomac.2024.131446

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mA-dependent upregulation of DDX21 by super-enhancer-driven IGF2BP2 and IGF2BP3 facilitates progression of acute myeloid leukaemia

Authors: Yanchun Zhao, Yutong Zhou, Yu Qian, Wenwen Wei, Xiangjie Lin, Shihui Mao, Jie Sun, Jie Jin

Journal: Clin Transl Med

PubMed ID: 38572589

Doi: 10.1002/ctm2.1628

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OsATL32 ubiquitinates the reactive oxygen species-producing OsRac5-OsRbohB module to suppress rice immunity

Authors: Yuqing Yan, Hui Wang, Yan Bi, Jiajing Wang, Muhammad Noman, Dayong Li, Fengming Song

Journal: J Integr Plant Biol

PubMed ID: 38629772

Doi: 10.1111/jipb.13666

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Label-free detection of Aβ-42: a liquid crystal droplet approach for Alzheimer's disease diagnosis

Authors: Saumya Ranjan Pradhan, Ramadevi Suguru Pathinti, Ramesh Kandimalla, Krishnakanth Chithari, Madhava Rao Veeramalla N, Jayalakshmi Vallamkondu

Journal: RSC Adv

PubMed ID: 38628477

Doi: 10.1039/d4ra00615a

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Therapeutic application of circular RNA aptamers in a mouse model of psoriasis

Authors: Si-Kun Guo, Chu-Xiao Liu, Yi-Feng Xu, Xiao Wang, Fang Nan, Youkui Huang, Siqi Li, Shan Nan, Ling Li, Edo Kon, Chen Li, Meng-Yuan Wei, Rina Su, Jia Wei, Shiguang Peng, Nitay Ad-El, Jiaquan Liu, Dan Peer, Ting Chen, Li Yang, Ling-Ling Chen

Journal: Nat Biotechnol

PubMed ID: 38653797

Doi: 10.1038/s41587-024-02204-4

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An ultraviolet-driven rescue pathway for oxidative stress to eye lens protein human gamma-D crystallin

Authors: Jake A Hill, Yvonne Nyathi, Sam Horrell, David von Stetten, Danny Axford, Robin L Owen, Godfrey S Beddard, Arwen R Pearson, Helen M Ginn, Briony A Yorke

Journal: Commun Chem

PubMed ID: 38600176

Doi: 10.1038/s42004-024-01163-w

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CAR affinity modulates the sensitivity of CAR-T cells to PD-1/PD-L1-mediated inhibition

Authors: Irene Andreu-Saumell, Alba Rodriguez-Garcia, Vanessa Mühlgrabner, Marta Gimenez-Alejandre, Berta Marzal, Joan Castellsagué, Fara Brasó-Maristany, Hugo Calderon, Laura Angelats, Salut Colell, Mara Nuding, Marta Soria-Castellano, Paula Barbao, Aleix Prat, Alvaro Urbano-Ispizua, Johannes B Huppa, Sonia Guedan

Journal: Nat Commun

PubMed ID: 38670972

Doi: 10.1038/s41467-024-47799-z

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Edaravone Dexborneol mitigates pathology in animal and cell culture models of Alzheimer's disease by inhibiting neuroinflammation and neuronal necroptosis

Authors: Chong Xu, Yilan Mei, Ruihan Yang, Qiudan Luo, Jienian Zhang, Xiaolin Kou, Jianfeng Hu, Yujie Wang, Yue Li, Rong Chen, Zhengping Zhang, Yuyuan Yao, Jian Sima

Journal: Cell Biosci

PubMed ID: 38678262

Doi: 10.1186/s13578-024-01230-8

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Intratumoural delivery of TRAIL mRNA induces colon cancer cell apoptosis

Authors: Tingxuan Gu, Mengqiao Wang, Xiaorong Fu, Xueli Tian, Juanjuan Bi, Ning Lu, Chen Chen, Shijia Yan, Ang Li, Luyun Wang, Xiang Li, Kangdong Liu, Zigang Dong

Journal: Biomed Pharmacother

PubMed ID: 38636395

Doi: 10.1016/j.biopha.2024.116603

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Milligram-scale assembly and NMR fingerprint of tau fibrils adopting the Alzheimer's disease fold

Authors: Pu Duan, Nadia El Mammeri, Mei Hong

Journal: J Biol Chem

PubMed ID: 38679331

Doi: 10.1016/j.jbc.2024.107326

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The Bifunctional Effects of Lactoferrin (LFcinB11) in Inhibiting Neural Cell Adhesive Molecule (NCAM) Polysialylation and the Release of Neutrophil Extracellular Traps (NETs)

Authors: Bo Lu, Si-Ming Liao, Shi-Jie Liang, Li-Xin Peng, Jian-Xiu Li, Xue-Hui Liu, Ri-Bo Huang, Guo-Ping Zhou

Journal: Int J Mol Sci

PubMed ID: 38731861

Doi: 10.3390/ijms25094641

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Constructing an Antibiotic-Free Protein Expression System for Ovalbumin Biosynthesis in Probiotic Nissle 1917

Authors: Cheng Liu, Xueqin Lv, Long Liu, Jianghua Li, Guocheng Du, Jian Chen, Yanfeng Liu

Journal: J Agric Food Chem

PubMed ID: 38574273

Doi: 10.1021/acs.jafc.4c00827

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Flow Cytometry-Based Measurement of Antibodies Specific for Cell Surface-Expressed Folded SARS-CoV-2 Receptor-Binding Domains

Authors: Al Nasar Ahmed Sehgal, Jera Safran, Bernhard Kratzer, Pia Gattinger, Robert B Stieger, Laszlo Musiejovsky, Doris Trapin, Paul Ettel, Ulrike Körmöczi, Arno Rottal, Kristina Borochova, Yulia Dorofeeva, Inna Tulaeva, Milena Weber, Katharina Grabmeier-Pfistershammer, Thomas Perkmann, Ursula Wiedermann, Rudolf Valenta, Winfried F Pickl

Journal: Vaccines (Basel)

PubMed ID: 38675759

Doi: 10.3390/vaccines12040377

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Circ_0087851 suppresses colorectal cancer malignant progression through triggering miR-593-3p/BAP1-mediated ferroptosis

Authors: Ming Huang, Ting Gao, Xianyong Chen, Junlei Yi, Xuan Zhou

Journal: J Cancer Res Clin Oncol

PubMed ID: 38642144

Doi: 10.1007/s00432-024-05643-3

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Role of G326 in Determining the Aggregation Propensity of R3 Tau Repeat: Insights from Studies on R1R3 Tau Construct

Authors: Allwin Ebenezer Sahayaraj, Arshad Abdul Vahid, Asmita Dhara, Ann Teres Babu, Vinesh Vijayan

Journal: J Phys Chem B

PubMed ID: 38676652

Doi: 10.1021/acs.jpcb.4c00123

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A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development

Authors: Zhijuan Hu 1, Liang Yang 2, Maolei Zhang 2, Haite Tang 2, Yile Huang 3, Yujie Su 4, Yingzhe Ding 3, Chong Li 2, Mengfei Wang 4, Yunhao Zhou 4, Qing Zhang 5, Liman Guo 5, Yue Wu 5, Qianqian Wang 6, Ning Liu 6, Haoran Kang 2, Yi Wu 2, Deyang Yao 2, Yukun Li 4, Zifeng Ruan 4, Hao Wang 2, Feixiang Bao 2, Guopan Liu 3, Junwei Wang 2, Yaofeng Wang 3, Wuming Wang 7, Gang Lu 7, Dajiang Qin 8, Duanqing Pei 9, Wai-Yee Chan 7, Xingguo Liu

Journal: Cell Metab

PubMed ID: 38703762

Doi: 10.1016/j.cmet.2024.04.012

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Cryo-EM structure of the human Asc-1 transporter complex

Authors: Yaning Li , Yingying Guo, Angelika Bröer, Lu Dai, Stefan Brӧer , Renhong Yan

Journal: Nat Commun

PubMed ID: 38589439

Doi: 10.1038/s41467-024-47468-1

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A novel engineered IL-21 receptor arms T-cell receptor-engineered T cells (TCR-T cells) against hepatocellular carcinoma

Authors: Wei Zhu, Zhiming Zhang, Jinzhang Chen, Xiaolan Chen, Lei Huang, Xiaoyong Zhang, Xuan Huang, Na Ma, Weikang Xu, Xuan Yi, Xinyu Lu, Xin Fu, Siwei Li, Guoheng Mo, Yiyue Wang, Guosheng Yuan, Mengya Zang, Qi Li, Xiaotao Jiang, Yajing He, Sha Wu, Yukai He, Yongyin Li, Jinlin Hou

Journal: Signal Transduct Target Ther

PubMed ID: 38643203

Doi: 10.1038/s41392-024-01792-6

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Dual mode of DDX3X as an ATP-dependent RNA helicase and ATP-independent nucleic acid chaperone

Authors: Yi-Ning He, Xiao-Rui Han, Dong Wang, Jia-Li Hou, Xi-Miao Hou

Journal: Biochem Biophys Res Commun

PubMed ID: 38669753

Doi: 10.1016/j.bbrc.2024.149964

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Ferroptosis and HMGB2 induced calreticulin translocation required for immunogenic cell death are controlled by the nuclear exporter XPO1

Authors: Ian Blair, Jingqi Fan, Kevin Gillespie, Clementina Mesaros

Journal: Res Sq

PubMed ID: 38496553

Doi: 10.21203/rs.3.rs-4009459/v1

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Developing Plant Exosomes as an Advanced Delivery System for Cosmetic Peptide

Authors: Jiali Hou, Wei Wei, Zaijun Geng, Zhenxing Zhang, Hui Yang, Xuhui Zhang, Li Li, Qi Gao

Journal: ACS Appl Bio Mater

PubMed ID: 38598772

Doi: 10.1021/acsabm.4c00096

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in Ticks Blood-Feeding on Migratory Birds in Sweden

Authors: Peter Wilhelmsson, Malin Lager, Thomas G T Jaenson, Jonas Waldenström, Björn Olsen, Per-Eric Lindgren

Journal: Microorganisms

PubMed ID: 38674679

Doi: 10.3390/microorganisms12040735

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Coiled-Coil Protein Hydrogels Engineered with Minimized Fiber Diameters for Sustained Release of Doxorubicin in Triple-Negative Breast Cancer

Authors: Dustin Britton, Jakub Legocki, Deven Paul, Olga Katsara, Orlando Aristizabal, Neelam Pandya, Orin Mishkit, Yingxin Xiao, Matias Aristizabal, Neha Rahman, Robert Schneider, Youssef Z Wadghiri, Jin Kim Montclare

Journal: ACS Biomater Sci Eng

PubMed ID: 38622760

Doi: 10.1021/acsbiomaterials.4c00349

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Protein localization of aquaporins in the adult female disease vector mosquito,

Authors: Britney Picinic, Jean-Paul V Paluzzi, Andrew Donini

Journal: Front Insect Sci

PubMed ID: 38699443

Doi: 10.3389/finsc.2024.1365651

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Validation for the function of protein C in mouse models

Authors: Ya Liu, Maoping Cai, Yan Chen, Guocai Wu, Songyu Li, Zhanghui Chen

Journal: PeerJ

PubMed ID: 38680896

Doi: 10.7717/peerj.17261

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Co-clustering of EphB6 and ephrinB1 in trans restrains cancer cell invasion

Authors: Lung-Yu Liang, Niall D Geoghegan, Michael Mlodzianoski, Andrew Leis, Lachlan W Whitehead, Minglyanna G Surudoi, Samuel N Young, Peter Janes, Doulin Shepherd, Debnath Ghosal, Kelly L Rogers, James M Murphy, Isabelle S Lucet

Journal: Commun Biol

PubMed ID: 38627519

Doi: 10.1038/s42003-024-06118-4

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Gene replacement therapy in Bietti crystalline corneoretinal dystrophy: an open-label, single-arm, exploratory trial

Authors: Jinyuan Wang, Jinlu Zhang, Shicheng Yu, Hongyan Li, Shaohong Chen, Jingting Luo, Haibo Wang, Yuxia Guan, Haihan Zhang, Shiyi Yin, Huili Wang, Heping Li, Junle Liu, Jingyuan Zhu, Qiong Yang, Ying Sha, Chuan Zhang, Yuhang Yang, Xuan Yang, Xifang Zhang, Xiuli Zhao, Likun Wang, Liping Yang, Wenbin Wei

Journal: Signal Transduct Target Ther

PubMed ID: 38653979

Doi: 10.1038/s41392-024-01806-3

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Identification of a homoarginine biosynthetic gene from a microcystin biosynthetic pathway in Fischerella sp PCC 9339

Authors: Xiaodan Ouyang, Matti Wahlsten, Maija Pollari, Endrews Delbaje, Jouni Jokela, David P Fewer

Journal: Toxicon

PubMed ID: 38670499

Doi: 10.1016/j.toxicon.2024.107733

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Depolymerization of SUMO chains induces slender to stumpy differentiation in T brucei bloodstream parasites

Authors: Paula Ana Iribarren, Lucía Ayelén Di Marzio, María Agustina Berazategui, Andreu Saura, Lorena Coria, Juliana Cassataro, Federico Rojas, Miguel Navarro, Vanina Eder Alvarez

Journal: PLoS Pathog

PubMed ID: 38635823

Doi: 10.1371/journal.ppat.1012166

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Stepwise activation of a metabotropic glutamate receptor

Authors: Kaavya Krishna Kumar, Haoqing Wang, Chris Habrian, Naomi R Latorraca, Jun Xu, Evan S O'Brien, Chensong Zhang, Elizabeth Montabana, Antoine Koehl, Susan Marqusee, Ehud Y Isacoff, Brian K Kobilka

Journal: Nature

PubMed ID: 38632403

Doi: 10.1038/s41586-024-07327-x

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FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy

Authors: Jack D Chan, Christina M Scheffler, Isabelle Munoz, Kevin Sek, Joel N Lee, Yu-Kuan Huang, Kah Min Yap, Nicole Y L Saw, Jasmine Li, Amanda X Y Chen, Cheok Weng Chan, Emily B Derrick, Kirsten L Todd, Junming Tong, Phoebe A Dunbar, Jiawen Li, Thang X Hoang, Maria N de Menezes, Emma V Petley, Joelle S Kim, Dat Nguyen, Patrick S K Leung, Joan So, Christian Deguit, Joe Zhu, Imran G House, Lev M Kats, Andrew M Scott, Benjamin J Solomon, Simon J Harrison, Jane Oliaro, Ian A Parish, Kylie M Quinn, Paul J Neeson, Clare Y Slaney, Junyun Lai, Paul A Beavis, Phillip K Darcy

Journal: Nature

PubMed ID: 38600376

Doi: 10.1038/s41586-024-07242-1

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Transmembrane conformation of the envelope protein of an alpha coronavirus, NL63

Authors: Iva Sučec, Yanina Pankratova, Mriganka Parasar, Mei Hong

Journal: Protein Sci

PubMed ID: 38501465

Doi: 10.1002/pro.4923

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Kalium channelrhodopsins effectively inhibit neurons

Authors: Stanislav Ott, Sangyu Xu, Nicole Lee, Ivan Hong, Jonathan Anns, Danesha Devini Suresh, Zhiyi Zhang, Xianyuan Zhang, Raihanah Harion, Weiying Ye, Vaishnavi Chandramouli, Suresh Jesuthasan, Yasunori Saheki, Adam Claridge-Chang

Journal: Nat Commun

PubMed ID: 38658537

Doi: 10.1038/s41467-024-47203-w

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RATA: A novel class A carbapenemase with broad geographic distribution and potential for global spread

Authors: Hongyan Luo, Zhishuang Yang, Ting Lei, Caixia Li, Zuoyong Zhou, Mingshu Wang, Dekang Zhu, Pei Li, Anchun Cheng

Journal: Sci Total Environ

PubMed ID: 38692330

Doi: 10.1016/j.scitotenv.2024.172873

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mARC1 in MASLD: Modulation of lipid accumulation in human hepatocytes and adipocytes

Authors: Amanda K Jones, Besnik Bajrami, Morgan K Campbell, Abdullah Mesut Erzurumluoglu, Qiusha Guo, Hongxing Chen, Xiaomei Zhang, Svetlana Zeveleva, David Kvaskoff, Andreas-David Brunner, Stefanie Muller, Vasudha Gathey, Rajvee M Dave, James W Tanner, Sophia Rixen, Michel A Struwe, Kathryn Phoenix, Kaitlyn J Klumph, Heather Robinson, Daniel Veyel, Annkatrin Muller, Boris Noyvert, Boris Alexander Bartholdy, Agnes A Steixner-Kumar, Jan Stutzki, Dmitriy Drichel, Steffen Omland, Ryan Sheehan, Jon Hill, Tom Bretschneider, Dirk Gottschling, Axel J Scheidig, Bernd Clement, Martin Giera, Zhihao Ding, John Broadwater, Curtis R Warren

Journal: Hepatol Commun

PubMed ID: 38619429

Doi: 10.1097/HC9.0000000000000365

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Probing actin-activated ATP turnover kinetics of human cardiac myosin II by single molecule fluorescence

Authors: Albin Berg, Lok Priya Velayuthan, Sven Tågerud, Marko Ušaj, Alf Månsson

Journal: Cytoskeleton (Hoboken)

PubMed ID: 38623952

Doi: 10.1002/cm.21858

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Improving the Quality of Wheat Flour Bread by a Thermophilic Xylanase with Ultra Activity and Stability Reconstructed by Ancestral Sequence and Computational-Aided Analysis

Authors: Guoshuai Hu, Xizhi Hong, Meixin Zhu, Lei Lei, Zhenggang Han, Yong Meng, Jiangke Yang

Journal: Molecules

PubMed ID: 38675714

Doi: 10.3390/molecules29081895

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Utility of accessible SARS-CoV-2 specific immunoassays in vaccinated adults with a history of advanced HIV infection

Authors: Ludovica Ferrari, Alessandra Ruggiero, Chiara Stefani, Livia Benedetti, Lorenzo Piermatteo, Eleonora Andreassi, Federica Caldara, Drieda Zace, Matteo Pagliari, Francesca Ceccherini-Silberstein, Christopher Jones, Marco Iannetta, Anna Maria Geretti

Journal: Sci Rep

PubMed ID: 38594459

Doi: 10.1038/s41598-024-58597-4

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Peptide Inhibitor Targeting the Extraterminal Domain in BRD4 Potently Suppresses Breast Cancer Both and

Authors: Qi-Xuan Huang, Da-Meng Fan, Zao-Zao Zheng, Ting Ran, Ao Bai, Rong-Quan Xiao, Guo-Sheng Hu, Wen Liu

Journal: J Med Chem

PubMed ID: 38569135

Doi: 10.1021/acs.jmedchem.4c00141

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