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Oat Peptides Alleviate Dextran Sulfate Sodium Salt-Induced Colitis by Maintaining the Intestinal Barrier and Modulating the Keap1-Nrf2 Axis

Authors: Zhong-Hao Ji, Wen-Yin Xie , Pei-Sen Zhao , Hong-Yu Wu , Wen-Zhi Ren , Jin-Ping Hu , Wei Gao , Bao Yuan

Journal: Nutrients .

PubMed ID: 38140314

Doi: 10.3390/nu15245055

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Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function

Authors: Leonardo A Parra-Rivas , Kayalvizhi Madhivanan , Brent D Aulston , Lina Wang , Dube Dheeraj Prakashchand , Nicholas P Boyer , Veronica M Saia-Cereda , Kristen Branes-Guerrero , Donald P Pizzo , Pritha Bagchi , V S Sundar , Yong Tang , Utpal Das , David A Scott , Padmini Rangamani , Yuki Ogawa , Subhojit Roy

Journal: Neuron .

PubMed ID: 38128479

Doi: 10.1016/j.neuron.2023.11.020

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Staphylococcus aureus functional amyloids catalyze degradation of β-lactam antibiotics

Authors: Elad Arad , Kasper B Pedersen , Orit Malka, Sisira Mambram Kunnath , Nimrod Golan , Polina Aibinder , Birgit Schiøtt , Hanna Rapaport, Meytal Landau , Raz Jelinek

Journal: Nat Commun .

PubMed ID: 38081813

Doi: s41467-023-43624-1

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Molecular mechanism of allosteric activation of the CRISPR ribonuclease Csm6 by cyclic tetra-adenylate

Authors: Liyang Du , Qinwei Zhu & Zhonghui Lin

Journal: The EMBO Journal

Doi: 10.1038/s44318-023-00017-w

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Structural dynamics of the CROPs domain control stability and toxicity of Paeniclostridium sordellii lethal toxin

Authors: Yao Zhou, Xiechao Zhan , Jianhua Luo, Diyin Li , Ruoyu Zhou , Jiahao Zhang , Zhenrui Pan , Yuanyuan Zhang , Tianhui Jia , Xiaofeng Zhang , Yanyan Li , Liang Tao

Journal: Nat Commun .

PubMed ID: 38114525

Doi: 10.1038/s41467-023-44169-z

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Structural analysis and functional evaluation of the disordered ß–hexosyltransferase region from Hamamotoa (Sporobolomyces) singularis

Authors: Suzanne F Dagher, Asmita Vaishnav, Christopher B Stanley, Flora Meilleur, Brian F P Edwards , José M Bruno-Bárcena

Journal: Front Bioeng Biotechnol

PubMed ID: 38162180

Doi: 10.3389/fbioe.2023.1291245

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Engineering minimal tissue inhibitors of metalloproteinase targeting MMPs via gene shuffling and yeast surface display

Authors: Arman Hosseini, Sachin Kumar, Kyle Hedin, Maryam Raeeszadeh-Sarmazdeh

Journal: Protein Sci

PubMed ID: 37807423

Doi: 10.1002/pro.4795

Products & Services: Proteins, Expression, Isolation and Analysis

A functional and structural comparative analysis of Large Tumor Antigens reveals evolution of different importin α-dependent nuclear localization signals

Authors: Emily M Cross, Nasim Akbari, Hanieh Ghassabian, Mikayla Hoad, Silvia Pavan, Daryl Ariawan, Camilla M Donnelly, Enrico Lavezzo, Gayle F Petersen, Jade K Forwood, Gualtiero Alvisi

Journal: Protein Sci

PubMed ID: 38108201

Doi: 10.1002/pro.4876

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Choosing the right mouse model: comparison of humanized NSG and NBSGW mice for in vivo HSC gene therapy

Authors: Seunga Choo, Carl B Wolf, Heather M Mack, Mitchell J Egan, Hans-Peter Kiem, Stefan Radtke

Journal: Blood Adv

PubMed ID: 38113461

Doi: 10.1182/bloodadvances.2023011371

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A highly conserved ligand-binding site for AccA transporters of antibiotic and quorum-sensing regulator in Agrobacterium leads to a different specificity

Authors: Solange Moréra, Armelle Vigouroux, Magali Aumont-Nicaise, Mohammed Ahmar, Thibault Meyer, Abbas El Sahili, Grégory Deicsics, Almudena González-Mula, Sizhe Li, Jeanne Doré, Serena Siragu, Pierre Legrand, Camille Penot, François Andrè, Denis Faure, Laurent Soulère, Yves Queneau, Ludovic Vial

Journal: Biochem J

PubMed ID: 38058289

Doi: 10.1042/BCJ20230273

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Secretory carrier-associated membrane protein 5 regulates cell-surface targeting of T-type calcium channels

Authors: Emilio R Mustafá, Konstantin Weiß, Norbert Weiss

Journal: Channels (Austin)

PubMed ID: 37389974

Doi: 10.1080/19336950.2023.2230776

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Structural and functional analysis of the minimal orthomyxovirus-like polymerase of Tilapia Lake Virus from the highly diverged Amnoonviridae family

Authors: Benoit Arragain, Martin Pelosse, Albert Thompson, Stephen Cusack

Journal: Nat Commun

PubMed ID: 38066000

Doi: 10.1038/s41467-023-44044-x

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N6-methyladenosine methylation analysis of long noncoding RNAs and mRNAs in 5-FU-resistant colon cancer cells

Authors: Jie Lai, Zhiyong Zhou, Kan Hu, HongLong Yu, Xingyao Su, Xiaoqiang Niu, Huizi Li, Shengxun Mao

Journal: Epigenetics

PubMed ID: 38145548

Doi: 10.1080/15592294.2023.2298058

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Safety and efficacy of a novel anti-CD19 chimeric antigen receptor T cell product targeting a membrane-proximal domain of CD19 with fast on- and off-rates against non-Hodgkin lymphoma: a first-in-human study

Authors: Yunlin Zhang, Ruchi P Patel, Ki Hyun Kim, Hyungwoo Cho, Jae-Cheol Jo, Seong Hyun Jeong, Sung Yong Oh, Yoon Seok Choi, Sung Hyun Kim, Ji Hyun Lee, Mathew Angelos, Puneeth Guruprasad, Ivan Cohen, Ositadimma Ugwuanyi, Yong Gu Lee, Raymone Pajarillo, Jong Hyun Cho, Alberto Carturan, Luca Paruzzo, Guido Ghilardi, Michael Wang, Soohwan Kim, Sung-Min Kim, Hyun-Jong Lee, Ji-Ho Park, Leiguang Cui, Tae Bum Lee, In-Sik Hwang, Young-Ha Lee, Yong-Jun Lee, Patrizia Porazzi, Dongfang Liu, Yoon Lee, Jong-Hoon Kim, Jong-Seo Lee, Dok Hyun Yoon, Junho Chung, Marco Ruella

Journal: Mol Cancer

PubMed ID: 38066564

Doi: 10.1186/s12943-023-01886-9

Products & Services: Recombinant Proteins

Plasma circRNA HIPK2 as a putative biomarker for the diagnosis and prediction of therapeutic effects in major depressive disorder

Authors: Xiaoyu Yu, Zhenyu Fan, Tingting Yang, Heng Li, Yachen Shi, Long Ye, Rongrong Huang

Journal: Clin Chim Acta

PubMed ID: 38065380

Doi: 10.1016/j.cca.2023.117694

Products & Services: Molecular Biology Reagents

A biosynthetic network for protoberberine production in

Authors: Linrui Wu, Binxin Zhao, Zixin Deng, Bin Wang, Yi Yu

Journal: Hortic Res

PubMed ID: 38282690

Doi: 10.1093/hr/uhad259

Products & Services: Gene Synthesis

DPY30 promotes colorectal carcinoma metastasis by upregulating ZEB1 transcriptional expression

Authors: Chun-Ying Luo, Wei-Chao Su, Hai-Feng Jiang, Ling-Tao Luo, Dong-Yan Shen, Guo-Qiang Su

Journal: Cancer Cell Int

PubMed ID: 38115111

Doi: 10.1186/s12935-023-03126-y

Products & Services: Proteins, Expression, Isolation and Analysis

Recombinant bovine FGF1 promotes muscle satellite cells mitochondrial fission and proliferation in serum-free conditions

Authors: Qingying Liu, Lianghua Xie, Wei Chen

Journal: Food Res Int

PubMed ID: 38129067

Doi: 10.1016/j.foodres.2023.113794

Products & Services: Gene Synthesis

Dachsous and Fat coordinately repress the Dachs–Dlish–Approximated complex to control growth

Authors: Hitoshi Matakatsu , Richard G Fehon

Journal: J Cell Biol

PubMed ID: 39373700

Doi: 10.1083/jcb.202406119

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Intranasal mask for protecting the respiratory tract against viral aerosols

Authors: Xiaoming Hu, Shuang Wang, Shaotong Fu, Meng Qin, Chengliang Lyu, Zhaowen Ding, Yan Wang, Yishu Wang, Dongshu Wang, Li Zhu, Tao Jiang, Jing Sun, Hui Ding, Jie Wu, Lingqian Chang, Yimin Cui, Xiaocong Pang, Youchun Wang, Weijin Huang, Peidong Yang, Limin Wang, Guanghui Ma, Wei Wei

Journal: Nat Commun

PubMed ID: 38110357

Doi: 10.1038/s41467-023-44134-w

Products & Services: Molecular Biology Reagents

Nuclear localization of Argonaute 2 is affected by cell density and may relieve repression by microRNAs

Authors: Krystal C Johnson, Audrius Kilikevicius, Cristina Hofman, Jiaxin Hu, Yang Liu, Selina Aguilar, Jon Graswich, Yi Han, Tao Wang, Jill M Westcott, Rolf A Brekken, Lan Peng, Georgios Karagkounis, David R Corey

Journal: Nucleic Acids Res

PubMed ID: 38109320

Doi: 10.1093/nar/gkad1155

Products & Services: Peptide Synthesis

Electrostatic-Dominated Conformational Fluctuations and Transition States of Phase Separation in Charge-Balanced Protein Polymer

Authors: Sougat Das, Tithi Basu, Saptarshi Majumdar

Journal: ACS Macro Lett

PubMed ID: 38109356

Doi: 10.1021/acsmacrolett.3c00625

Products & Services: Peptide Synthesis

Sensitive Blood-Based Detection of HIV-1 and Mycobacterium tuberculosis Peptides for Disease Diagnosis by Immuno-Affinity Liquid Chromatography-Tandem Mass Spectrometry: A Method Development and Proof-of-Concept Study

Authors: Lin Li, Christopher J Lyon, Sylvia M LaCourse, Wenshu Zheng, Joshua Stern, Jaclyn N Escudero, Wilfred Bundi Murithi, Lilian Njagi, Grace John-Stewart, Thomas R Hawn, Videlis Nduba, Wael Abdelgaliel, Thomas Tombler, David Horne, Li Jiang, Tony Y Hu

Journal: Clin Chem

PubMed ID: 37956323

Doi: 10.1093/clinchem/hvad173

Products & Services: Peptide Synthesis

Novel SOX10 indel mutations drive schwannomas through impaired transactivation of myelination gene programs

Authors: Erik A Williams, Ajay Ravindranathan, Rohit Gupta, Nicholas O Stevers, Abigail K Suwala, Chibo Hong, Somang Kim, Jimmy Bo Yuan, Jasper Wu, Jairo Barreto, Calixto-Hope G Lucas, Emily Chan, Melike Pekmezci, Philip E LeBoit, Thaddeus Mully, Arie Perry, Andrew Bollen, Jessica Van Ziffle, W Patrick Devine, Alyssa T Reddy, Nalin Gupta, Kristen M Basnet, Robert J B Macaulay, Patrick Malafronte, Han Lee, William H Yong, Kevin Jon Williams, Tareq A Juratli, Douglas A Mata, Richard S P Huang, Matthew C Hiemenz, Dean C Pavlick, Garrett M Frampton, Tyler Janovitz, Jeffrey S Ross, Susan M Chang, Mitchel S Berger, Line Jacques, Jun S Song, Joseph F Costello, David A Solomon

Journal: Neuro Oncol

PubMed ID: 37436963

Doi: 10.1093/neuonc/noad121

Products & Services: Proteins, Expression, Isolation and Analysis

Phage Tail Fiber Protein as a Specific Probe for Recognition of Shiga Toxin-Producing O91, O103, and O111

Authors: Yibao Chen, Lulu Li, Xiaotian Wei, Ming Hu, Xiaonan Zhao, Qing Zhang, Yanbo Luo, Min Zhao, Zhengjie Liu, Yumei Cai, Yuqing Liu

Journal: Anal Chem

PubMed ID: 38053255

Doi: 10.1021/acs.analchem.3c03370

Products & Services: Molecular Biology Reagents

The function of ER-phagy receptors is regulated through phosphorylation-dependent ubiquitination pathways

Authors: Rayene Berkane, Hung Ho-Xuan, Marius Glogger, Pablo Sanz-Martinez, Lorène Brunello, Tristan Glaesner, Santosh Kumar Kuncha, Katharina Holzhüter, Sara Cano-Franco, Viviana Buonomo, Paloma Cabrerizo-Poveda, Ashwin Balakrishnan, Georg Tascher, Koraljka Husnjak, Thomas Juretschke, Mohit Misra, Alexis González, Volker Dötsch, Paolo Grumati, Mike Heilemann, Alexandra Stolz

Journal: Nat Commun

PubMed ID: 38102139

Doi: 10.1038/s41467-023-44101-5

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Ubiquitin-specific protease 22 promotes tumorigenesis and progression by an FKBP12/mTORC1/autophagy positive feedback loop in hepatocellular carcinoma

Authors: Qianwei Ye, Wei Zhou, Shengjun Xu, Qingyang Que, Qifan Zhan, Lincheng Zhang, Shusen Zheng, Sunbin Ling, Xiao Xu

Journal: MedComm (2020)

PubMed ID: 38045832

Doi: 10.1002/mco2.439

Products & Services: Proteins, Expression, Isolation and Analysis

Authors: Yunxiang Zhao, Jiali Qin, Jingshuai Sun, Jian He, Yanmei Sun, Renqiang Yuan, Zhili Li

Journal: Theriogenology

PubMed ID: 38150851

Doi: 10.1016/j.theriogenology.2023.11.028

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Addressing the Binding Mechanism of the Meprin and TRAF-C Homology Domain of the Speckle-Type POZ Protein Using Protein Engineering

Authors: Awa Diop, Paola Pietrangeli, Valeria Pennacchietti, Livia Pagano, Angelo Toto, Mariana Di Felice, Sara Di Matteo, Lucia Marcocci, Francesca Malagrinò, Stefano Gianni

Journal: Int J Mol Sci

PubMed ID: 38139193

Doi: 10.3390/ijms242417364

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Combinatorial design of ionizable lipid nanoparticles for muscle-selective mRNA delivery with minimized off-target effects

Authors: Jingan Chen, Yue Xu, Muye Zhou, Shufen Xu, Andrew James Varley, Alex Golubovic, Rick Xing Ze Lu, Kevin Chang Wang, Mina Yeganeh, Daniel Vosoughi, Bowen Li

Journal: Proc Natl Acad Sci U S A

PubMed ID: 38060560

Doi: 10.1073/pnas.2309472120

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The role of CE16 exo-deacetylases in hemicellulolytic enzyme mixtures revealed by the biochemical and structural study of the novel TtCE16B esterase

Authors: Christina Pentari, Anastasia Zerva, Christos Kosinas, Panagiota Karampa, Vladimír Puchart, Maria Dimarogona, Evangelos Topakas

Journal: Carbohydr Polym

PubMed ID: 38171682

Doi: 10.1016/j.carbpol.2023.121667

Products & Services: Molecular Biology Reagents

A novel biomarker of MMP-cleaved cartilage intermediate layer protein-1 is elevated in patients with rheumatoid arthritis, ankylosing spondylitis and osteoarthritis

Authors: Helena Port, Cecilie Møller Hausgaard, Yi He, Walter P Maksymowych, Stephanie Wichuk, Dovile Sinkeviciute, Anne-Christine Bay-Jensen, Signe Holm Nielsen

Journal: Sci Rep

PubMed ID: 38066013

Doi: 10.1038/s41598-023-48787-x

Products & Services: Proteins, Expression, Isolation and Analysis

Rapid detection of in sputum using CRISPR-Cas12b combined with cross-priming amplification in a single reaction

Authors: Lijun Peng, Tingting Fang, Qingshan Cai, Hao Li, Huanyu Li, Haiqiong Sun, Mingzhi Zhu, Lingshan Dai, Yanqin Shao, Long Cai

Journal: J Clin Microbiol

PubMed ID: 38112450

Doi: 10.1128/jcm.00923-23

Products & Services: Molecular Biology Reagents

Development of a double-antibody sandwich enzyme-linked immunosorbent assay for rapid detection of VZV

Authors: Aiping Wang, Na Liu, Jianguo Zhao, Yan Niu, Yumei Chen, Jingming Zhou, Enping Liu, Gaiping Zhang

Journal: J Virol Methods

PubMed ID: 38154579

Doi: 10.1016/j.jviromet.2023.114874

Products & Services: Molecular Biology Reagents

Superior antibody and membrane protein-specific T-cell responses to CoronaVac by intradermal versus intramuscular routes in adolescents

Authors: Jaime S Rosa Duque, Samuel M S Cheng, Carolyn A Cohen, Daniel Leung, Xiwei Wang, Xiaofeng Mu, Yuet Chung, Tsun Ming Lau, Manni Wang, Wenyue Zhang, Yanmei Zhang, Howard H W Wong, Leo C H Tsang, Sara Chaothai, Tsz Chun Kwan, John K C Li, Karl C K Chan, Leo L H Luk, Jenson C H Ho, Wing Yan Li, Amos M T Lee, Jennifer H Y Lam, Sau Man Chan, Wilfred H S Wong, Issan Y S Tam, Masashi Mori, Sophie A Valkenburg, Malik Peiris, Wenwei Tu, Yu Lung Lau

Journal: World J Pediatr

PubMed ID: 38085470

Doi: 10.1007/s12519-023-00764-0

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Intracellular cholesterol visualization in brain tissue using D4H

Authors: Sherida M de Leeuw, Tal Nuriel

Journal: STAR Protoc

PubMed ID: 38100357

Doi: 10.1016/j.xpro.2023.102779

Products & Services: Recombinant Proteins

Molecular Characterization of Tick-borne Pathogens in Bactrian Camels and Ticks from Gansu Province, China

Authors: Hong-Xi Zhao, Xiao-Qing Zan, Jin-Zhong Tao, Xin-Gang Dan

Journal: Acta Parasitol

PubMed ID: 38087038

Doi: 10.1007/s11686-023-00752-4

Products & Services: Recombinant Proteins

Purification of Human Cytoplasmic Actins From

Authors: Brian K Haarer, David C Amberg, Jessica L Henty-Ridilla

Journal: Bio Protoc

PubMed ID: 38094253

Doi: 10.21769/BioProtoc.4894

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Efficacy of cyclobutrifluram in controlling Fusarium crown rot of wheat and resistance risk of three Fusarium species to cyclobutrifluram

Authors: Haiyan Sun, Shiyan Cai, Yuanyu Deng, Shulin Cao, Xiaoyue Yang, Yanteng Lu, Wei Li, Huaigu Chen

Journal: Pestic Biochem Physiol

PubMed ID: 38225078

Doi: 10.1016/j.pestbp.2023.105723

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Shenqi Fuzheng injection restores the sensitivity to gefitinib in non-small cell lung cancer by inhibiting the IL-22 STAT3 AKT pathway

Authors: Jiali Wang , Xianhai He , Zhirong Jia , Aiwen Yan , Kang Xiao , Shuo Liu , Mengjun Hou , Yaling Long , Xuansheng Ding

Journal: Pharm Biol .

PubMed ID: 38100532

Doi: 10.1080/13880209.2023.2292266

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A KDPG sensor RccR governs Pseudomonas aeruginosa carbon metabolism and aminoglycoside antibiotic tolerance

Authors: Yujue Wang , Zhipeng Wang , Weizhong Chen , Ze-Hui Ren , Hui Gao , Jiani Dai , Guan-Zheng Luo , Zhaowei Wu , Quanjiang Ji

Journal: Nucleic Acids Res .

PubMed ID: 38096062

Doi: 10.1093/nar/gkad1201

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Synthetic High-Density Lipoprotein-Based Nanomedicine to Silence SOCS1 in Tumor Microenvironment and Trigger Antitumor Immunity against Glioma

Authors: Chunrong Yang , Yujie Li , Yuchen Yang , Qiankun Ni , Zeyu Zhang , Yi Chai , Jinghong Li

Journal: Angew Chem Int Ed Engl .

PubMed ID: 37847126

Doi: 10.1002/anie.202312603

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Structure and mechanism of a eukaryotic ceramide synthase complex

Authors: Tian Xie , Qi Fang , Zike Zhang , Yanfei Wang , Feitong Dong , Xin Gong

Journal: EMBO J .

PubMed ID: 37953642

Doi: 10.15252/embj.2023114889

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Biguanide chitosan microneedles with cell-free DNA scavenging ability for psoriasis therapy

Authors: Zihao Liu , Yu Wang , Yuhan Zhang , Liufu Hu , Bozhi Chen , Yang Li , Xindong Guo , Bingran Yu , Fu-Jian Xu

Journal: Bioactive Materials

Doi: 10.1016/j.bioactmat.2023.11.015

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The global transcription regulator XooClp governs Type IV pili system mediated bacterial virulence by directly binding to their promoters to coordinate virulence associated functions

Authors: Raj Kumar Verma, Parimala Gondu, Tirthankar Saha, Subhadeep Chatterjee

Journal: Mol Plant Microbe Interact

PubMed ID: 38105438

Doi: 10.1094/MPMI-07-23-0100-R

Products & Services: Proteins, Expression, Isolation and Analysis

Mucosal SARS-CoV-2 vaccination of rodents elicits superior systemic T central memory function and cross-neutralising antibodies against variants of concern

Authors: Aled O'Neill, Chinmay Kumar Mantri, Chee Wah Tan, Wilfried A A Saron, Santhosh Kambaiah Nagaraj, Monica Palanichamy Kala, Christy Margarat Joy, Abhay P S Rathore, Shashank Tripathi, Lin-Fa Wang, Ashley L St John

Journal: EBioMedicine

PubMed ID: 38113758

Doi: 10.1016/j.ebiom.2023.104924

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Mutant GGGGCC RNA prevents YY1 from binding to Fuzzy promoter which stimulates Wnt/β-catenin pathway in C9ALS/FTD

Authors: Zhefan Stephen Chen, Mingxi Ou, Stephanie Taylor, Ruxandra Dafinca, Shaohong Isaac Peng, Kevin Talbot, Ho Yin Edwin Chan

Journal: Nat Commun

PubMed ID: 38110419

Doi: 10.1038/s41467-023-44215-w

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RIF1 regulates early replication timing in murine B cells

Authors: Daniel Malzl, Mihaela Peycheva, Ali Rahjouei, Stefano Gnan, Kyle N Klein, Mariia Nazarova, Ursula E Schoeberl, David M Gilbert, Sara C B Buonomo, Michela Di Virgilio, Tobias Neumann, Rushad Pavri

Journal: Nat Commun

PubMed ID: 38081811

Doi: 10.1038/s41467-023-43778-y

Products & Services: Proteins, Expression, Isolation and Analysis

Evaluation of immunogenicity-induced DNA vaccines against different SARS-CoV-2 variants

Authors: Se Eun Kim, So Hee Park, Woo-Jung Park, Gayeong Kim, Seo Yeon Kim, Hyeran Won, Yun-Ho Hwang, Heeji Lim, Hyeon Guk Kim, You-Jin Kim, Dokeun Kim, Jung-Ah Lee

Journal: PLoS ONE

PubMed ID: 38060612

Doi: 10.1371/journal.pone.0295594

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, an AP2 and B3 Transcription Factor, Positively Regulates Eggplant's Response to Salt Stress

Authors: Junjie Ding, Bowen Yao, Xu Yang, Lei Shen

Journal: Plants (Basel)

PubMed ID: 38140500

Doi: 10.3390/plants12244174

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