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NpeA is a secreted Type IV effector containing an N-WASP-binding short linear motif that promotes niche formation

Authors: Agostina Giménez, Mariela G Del Giudice, Paula V López, Francisco Guaimas, Hugo Sámano-Sánchez, Toby J Gibson, Lucía B Chemes, Carlos O Arregui, Juan E Ugalde, Cecilia Czibener

Journal: MBio

PubMed ID: 38847540

Doi: 10.1128/mbio.00726-24

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A safe and potentiated multi-type HPV L2-E7 nanoparticle vaccine with combined prophylactic and therapeutic activity

Authors: Xueer Zhao, Yueru Zhang, Oscar Trejo-Cerro, Ecem Kaplan, Zhe Li, Femke Albertsboer, Neyla El Hammiri, Filipe Colaço Mariz, Lawrence Banks, Simone Ottonello, Martin Müller

Journal: npj Vaccines

PubMed ID: 38926425

Doi: 10.1038/s41541-024-00914-z

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Estrogen-mediated DNMT1 and DNMT3A recruitment by EZH2 silences miR-570-3p that contributes to papillary thyroid malignancy through DPP4

Authors: Xiarong Hu, Qingyao Ye, HuanQuan Lu, Zhiming Wu, Siyuan Chen, Ruinian Zheng

Journal: Clin Epigenetics

PubMed ID: 38890707

Doi: 10.1186/s13148-024-01685-z

Products & Services: Protein Electrophoresis and Western

Mitochondrial DNA transcription and mitochondrial genome-encoded long noncoding RNA in diabetic retinopathy

Authors: Jay Kumar, Renu A Kowluru

Journal: Mitochondrion

PubMed ID: 38944370

Doi: 10.1016/j.mito.2024.101925

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Anticancer Activity of HER2-targeting CPP-PTEN-THP Chimeric Proteins

Authors: Elizeth Pioquinto-Avila, Aldo O González-Cruz, Jorge Solís-Estrada, Javier Hernández-Juarez, Isaías Balderas-Rentería, Sheila Adela Villa-Cedillo, José Juan Pérez-Trujillo, Eder Arredondo-Espinoza

Journal: Anticancer Res

PubMed ID: 38821612

Doi: 10.21873/anticanres.17062

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A ternary correlation multi-symptom network strategy based on in vivo chemical profile identification and metabolomics to explore the molecular basis of Ephedra herb against viral pneumonia

Authors: Xiaoyan Wang, Jie Mei, Fan Zhang, Miaomiao Wei, Yujun Xie, Alamusi Bayoude, Xiufeng Liu, Boli Zhang, Boyang Yu

Journal: J Sep Sci

PubMed ID: 38819782

Doi: 10.1002/jssc.202400090

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Investigation of SARS-CoV-2 Infection among Companion Animals in Households with Confirmed Human COVID-19 Cases

Authors: Heather Venkat, Hayley D Yaglom, Gavriella Hecht, Andrew Goedderz, Jennifer L Ely, Michael Sprenkle, Taylor Martins, Daniel Jasso-Selles, Darrin Lemmer, Jordan Gesimondo, Irene Ruberto, Kenneth Komatsu, David M Engelthaler

Journal: Pathogens

PubMed ID: 38921764

Doi: 10.3390/pathogens13060466

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Chemical modification, structure elucidation and antifungal mechanism studies of a peptide extracted from garlic (Allium sativum L)

Authors: Shuqin Li, Junyu Liu, Tingting Zhang, Jingyang Lu, Mingyue Li, Min Zhang, Haixia Chen

Journal: J Sci Food Agric

PubMed ID: 38855916

Doi: 10.1002/jsfa.13633

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Cationic lipid nanoparticle-mediated delivery of a Cas9/crRNA ribonucleoprotein complex for transgene-free editing of the citrus plant genome

Authors: Lamiaa M Mahmoud, Manjul Dutt

Journal: Plant Cell Rep

PubMed ID: 38874819

Doi: 10.1007/s00299-024-03254-3

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DNA-controlled protein fluorescence: Design of aptamer-split peptide hetero-modulator for GFP to respond to intracellular ATP levels

Authors: Ki Sung Park, Hanvit Cha, Jia Niu, Hyongsok Tom Soh, Jin Hyup Lee, Seung Pil Pack

Journal: Nucleic Acids Res

PubMed ID: 38917331

Doi: 10.1093/nar/gkae532

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Astragaloside IV inhibits cell viability and glycolysis of hepatocellular carcinoma by regulating KAT2A-mediated succinylation of PGAM1

Authors: Yuanzhang Zhu, Fei Lu

Journal: BMC Cancer

PubMed ID: 38835015

Doi: 10.1186/s12885-024-12438-9

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One-shot design elevates functional expression levels of a voltage-gated potassium channel

Authors: Jonathan Jacob Weinstein, Chandamita Saikia, Izhar Karbat, Adi Goldenzweig, Eitan Reuveny, Sarel Jacob Fleishman

Journal: Protein Sci

PubMed ID: 38747377

Doi: 10.1002/pro.4995

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The Interplay of Acetylation and Ubiquitination Controls PRMT1 Homeostasis

Authors: Mohd Altaf Najar, Jenna N Beyer, Callie E W Crawford, George M Burslem

Journal: biorxiv

PubMed ID: 38948822

Doi: 10.1101/2024.06.18.599616

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An Ochratoxin a DNA Aptamer-Mediated Transcriptional Regulatory Riboswitch Biosensor

Authors: Xiaoze Dong, Shuo Qi, Pengfei Ma, Hongtao Jiang, Mingwei Qin, Ning Ding, Yin Zhang, Zhouping Wang

Journal: J Agric Food Chem

PubMed ID: 38847536

Doi: 10.1021/acs.jafc.4c02968

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APOE2 protects against Aβ pathology by improving neuronal mitochondrial function through ERRα signaling

Authors: Zhiyuan Ning, Ying Liu, Mengyao Wan, You Zuo, Siqi Chen, Zhongshan Shi, Yongteng Xu, Honghong Li, Ho Ko, Jing Zhang, Songhua Xiao, Daji Guo, Yamei Tang

Journal: Cell Mol Biol Lett

PubMed ID: 38867189

Doi: 10.1186/s11658-024-00600-x

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Efficient site-specific integration of large genes in mammalian cells via continuously evolved recombinases and prime editing

Authors: Smriti Pandey, Xin D Gao, Nicholas A Krasnow, Amber McElroy, Y Allen Tao, Jordyn E Duby, Benjamin J Steinbeck, Julia McCreary, Sarah E Pierce, Jakub Tolar, Torsten B Meissner, Elliot L Chaikof, Mark J Osborn, David R Liu

Journal: Nat Biomed Eng

PubMed ID: 38858586

Doi: 10.1038/s41551-024-01227-1

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A quadrivalent recombinant influenza Hemagglutinin vaccine induced strong protective immune responses in animal models

Authors: Jin Feng, Yingying Du, Liyun Chen, Wenhan Su, Hailiu Wei, Aijiao Liu, Xiaojun Jiang, Jianmin Guo, Cailing Dai, Yuhua Xu, Tao Peng

Journal: Vaccine

PubMed ID: 38834431

Doi: 10.1016/j.vaccine.2024.05.056

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Exploring solute binding proteins in Pseudomonas aeruginosa that bind to γ-aminobutyrate and 5-aminovalerate and their role in activating sensor kinases

Authors: Jean Paul Cerna-Vargas, Tino Krell

Journal: Microbiologyopen

PubMed ID: 38780167

Doi: 10.1002/mbo3.1415

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A self-healing multispectral transparent adhesive peptide glass

Authors: Gal Finkelstein-Zuta, Zohar A Arnon, Thangavel Vijayakanth, Or Messer, Orr Simon Lusky, Avital Wagner, Galit Zilberman, Ruth Aizen, Lior Michaeli, Sigal Rencus-Lazar, Sharon Gilead, Sudha Shankar, Mariela Jorgelina Pavan, Dor Aaron Goldstein, Shira Kutchinsky, Tal Ellenbogen, Benjamin A Palmer, Amir Goldbourt, Maxim Sokol, Ehud Gazit

Journal: Nature

PubMed ID: 38867128

Doi: 10.1038/s41586-024-07408-x

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Bioorthogonal non-canonical amino acid tagging to track transplanted human induced pluripotent stem cell-specific proteome

Authors: Divya Sridharan, Julie A Dougherty, Uzair Ahmed, Shridhar K Sanghvi, Syed Baseeruddin Alvi, Ki Ho Park, Helena Islam, Sue E Knoblaugh, Harpreet Singh, Elizabeth D Kirby, Mahmood Khan

Journal: Stem Cell Res Ther

PubMed ID: 38926849

Doi: 10.1186/s13287-024-03792-3

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Dectin-1-Targeted Antifungal Liposomes Exhibit Enhanced Efficacy

Authors: Suresh Ambati; Aileen R. Ferarro; S. Earl Khang; Jianfeng Lin; Xiaorong Lin; Michelle Momany; Zachary A. Lewis; Richard B. Meagher

Journal: mSphere

PubMed ID: 30760610

Doi: 10.1128/mSphere.00025-19

Dectin-1-Targeted Antifungal Liposomes Exhibit Enhanced Efficacy

Authors: Suresh Ambati; Aileen R. Ferarro; S. Earl Khang; Jianfeng Lin; Xiaorong Lin; Michelle Momany; Zachary A. Lewis; Richard B. Meagher

Journal: mSphere

PubMed ID: 30760610

Doi: 10.1128/mSphere.00025-19

Highly biased agonism for GPCR ligands via nanobody tethering

Authors: Shivani Sachdev, Brendan A Creemer, Thomas J Gardella, Ross W Cheloha

Journal: Nat Commun

PubMed ID: 38824166

Doi: 10.1038/s41467-024-49068-5.

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A growth selection system for sucrose synthases (SuSy): design and test

Authors: Gonzalo N Bidart, Se Hyeuk, Tobias Benedikt Alter, Lei Yang, Ditte Hededam Welner

Journal: AMB Express

PubMed ID: 38865019

Doi: 10.1186/s13568-024-01727-y

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BRET-based biosensors for SARS-CoV-2 oligonucleotide detection

Authors: Asfia Sultana, Anupriya M Geethakumari, Zeyaul Islam, Prasanna R Kolatkar, Kabir H Biswas

Journal: Front Bioeng Biotechnol

PubMed ID: 38887615

Doi: 10.3389/fbioe.2024.1353479

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Next-generation nanovaccine induces durable immunity and protects against SARS-CoV-2

Authors: Kathleen A Ross, Sean Kelly, Kruttika S Phadke, Nathan Peroutka-Bigus, Olufemi Fasina, Alaric Siddoway, Surya K Mallapragada, Michael J Wannemuehler, Bryan H Bellaire, Balaji Narasimhan

Journal: Acta Biomater

PubMed ID: 38844193

Doi: 10.1016/j.actbio.2024.05.048

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Protein engineering enables a soakable crystal form of human CDK7 primed for high-throughput crystallography and structure-based drug design

Authors: Manjeet Mukherjee, Philip J Day, Duncan Laverty, Juan A Bueren-Calabuig, Andrew J Woodhead, Charlotte Griffiths-Jones, Steve Hiscock, Charlotte East, Susan Boyd, Marc O'Reilly

Journal: Structure

PubMed ID: 38870939

Doi: 10.1016/j.str.2024.05.011

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Repeat controlled human Plasmodium falciparum infections delay bloodstream patency and reduce symptoms

Authors: Patricia Ferrer, Andrea A Berry, Allison N Bucsan, Surendra K Prajapati, Karthik Krishnan, Michelle C Barbeau, David M Rickert, Sandra Mendoza Guerrero, Miho Usui, Yonas Abebe, Asha Patil, Sumana Chakravarty, Peter F Billingsley, Faith Pa'ahana-Brown, Kathy Strauss, Biraj Shrestha, Effie Nomicos, Gregory A Deye, B Kim Lee Sim, Stephen L Hoffman, Kim C Williamson, Kirsten E Lyke

Journal: Nat Commun

PubMed ID: 38890271

Doi: 10.1038/s41467-024-49041-2

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The generation of stable transgenic lines in the human-infective nematode Strongyloides stercoralis

Authors: Ruhi Patel, Astra S Bryant, Michelle L Castelletto, Breanna Walsh, Damia Akimori, Elissa A Hallem

Journal: G3 (Bethesda)

PubMed ID: 38839055

Doi: 10.1093/g3journal/jkae122

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The role of shear forces in primary and secondary nucleation of amyloid fibrils

Authors: Emil Axell, Jing Hu, Max Lindberg, Alexander J Dear, Lei Ortigosa-Pascual, Ewa A Andrzejewska, Greta Šneiderienė, Dev Thacker, Tuomas P J Knowles, Emma Sparr, Sara Linse

Journal: Proc Natl Acad Sci U S A

PubMed ID: 38875148

Doi: 10.1073/pnas.2322572121

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The BICD2 dynein cargo adaptor binds to the HPV16 L2 capsid protein and promotes HPV infection

Authors: Kaitlyn Speckhart, Jeongjoon Choi, Daniel DiMaio, Billy Tsai

Journal: PLoS Pathog

PubMed ID: 38829892

Doi: 10.1371/journal.ppat.1012289

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Dual-Omics Approach Unveils Novel Perspective on the Quality Control of Genetically Engineered Exosomes

Authors: Christopher Olson, Konstantin Ivanov, Darin Boyes, David Bengford, Joy Ku, Renceh Flojo, Pengyang Zhang, Biao Lu

Journal: Pharmaceutics

PubMed ID: 38931944

Doi: 10.3390/pharmaceutics16060824

Products & Services: Molecular Biology Reagents

Improvement of TaC9-ABE mediated correction of human SMN2 gene

Authors: Xiaohua Peng, Yue Chi, Jinling Wang, Shuangpeng Li, Yang Liu, Chengcheng Tang, Xiaoqing Zhou, Xuan Lu, Yue Gao, Liangxue Lai, Min Chen, Qingjian Zou

Journal: Biotechnol Bioeng

PubMed ID: 38923503

Doi: 10.1002/bit.28780

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The annotation of has been concealed by its protein-coding pseudogene

Authors: Emil K Gustavsson, Siddharth Sethi, Yujing Gao, Jonathan W Brenton, Sonia García-Ruiz, David Zhang, Raquel Garza, Regina H Reynolds, James R Evans, Zhongbo Chen, Melissa Grant-Peters, Hannah Macpherson, Kylie Montgomery, Rhys Dore, Anna I Wernick, Charles Arber, Selina Wray, Sonia Gandhi, Julian Esselborn, Cornelis Blauwendraat, Christopher H Douse, Anita Adami, Diahann A M Atacho, Antonina Kouli, Annelies Quaegebeur, Roger A Barker, Elisabet Englund, Frances Platt, Johan Jakobsson, Nicholas W Wood, Henry Houlden, Harpreet Saini, Carla F Bento, John Hardy, Mina Ryten

Journal: Sci Adv

PubMed ID: 38924406

Doi: 10.1126/sciadv.adk1296

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Designing monomeric IFNγ: the significance of domain-swapped dimer structure in IFNγ immune responses

Authors: Yota Goto, Takamitsu Miyafusa, Shinya Honda

Journal: J Biol Chem

PubMed ID: 38879015

Doi: 10.1016/j.jbc.2024.107464

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Integrated pathway mining and selection of an artificial CYP79-mediated bypass to improve benzylisoquinoline alkaloid biosynthesis

Authors: Musashi Takenaka, Kouhei Kamasaka, Kim Daryong, Keiko Tsuchikane, Seiha Miyazawa, Saeko Fujihana, Yoshimi Hori, Christopher J Vavricka, Akira Hosoyama, Hiroko Kawasaki, Tomokazu Shirai, Michihiro Araki, Akira Nakagawa, Hiromichi Minami, Akihiko Kondo, Tomohisa Hasunuma

Journal: Microb Cell Fact

PubMed ID: 38879464

Doi: 10.1186/s12934-024-02453-7

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Arabidopsis pollen prolyl-hydroxylases P4H4/6 are relevant for correct hydroxylation and secretion of LRX11 in pollen tubes

Authors: Ana R Sede, Diego L Wengier, Cecilia Borassi, Martiniano Ricardi, Sofía C Somoza, Rafael Aguiló, José M Estevez, Jorge P Muschietti

Journal: J Exp Bot

PubMed ID: 38877792

Doi: 10.1093/jxb/erae269

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Functional characterization of polyphenol oxidase OfPPO2 supports its involvement in parallel biosynthetic pathways of acteoside

Authors: Yating Liu, Xiaoyang Han, Mengya Zhao, Lan Liu, Zixin Deng, Qiu Zhao, Yi Yu

Journal: PLANT JOURNAL

PubMed ID: 38872484

Doi: 10.1111/tpj.16807

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Divergent humoral responses between males and females against 24 kDa excretory-secretory protein of Haemonchus contortus and influence of ovine β-globin polymorphism

Authors: Cintia Hiromi Okino, Simone Cristina Méo Niciura, Alessandro Pelegrine Minho, Sérgio Novita Esteves, Gláucia Roberta Melito, Hélio José Montassier, Ana Carolina de Souza Chagas

Journal: Dev Comp Immunol

PubMed ID: 38901502

Doi: 10.1016/j.dci.2024.105216

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Identification of potential crucial cuproptosis-related genes in myocardial ischemia-reperfusion injury through the bioinformatic analysis

Authors: Rong Huang, Rongfeng Xu, Rui Zhang, Wenjie Zuo, Zhenjun Ji, Zaixiao Tao, Yongjun Li, Genshan Ma

Journal: Clinics (Sao Paulo)

PubMed ID: 38901133

Doi: 10.1016/j.clinsp.2024.100410

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Transcriptional genes of lysosome-associated membrane protein 2A in sciatic nerve injuries by bioinformatics

Authors: Eun Jung Sohn, Kun-Taek Park

Journal: Neuroreport

PubMed ID: 38935077

Doi: 10.1097/WNR.0000000000002066

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Ancient nitrogenases are ATP dependent

Authors: Derek F Harris, Holly R Rucker, Amanda K Garcia, Zhi-Yong Yang, Scott D Chang, Hannah Feinsilber, Betül Kaçar, Lance C Seefeldt

Journal: MBio

PubMed ID: 38869277

Doi: 10.1128/mbio.01271-24

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CEPs suppress auxin signaling but promote cytokinin signaling to inhibit root growth in Arabidopsis

Authors: Yuwen Zhang, Xingliang Duan, Zhen Wang, Yuanda Lv, Weicong Qi, Lun Li, Le Luo, Wei Xuan

Journal: Biochem Biophys Res Commun .

PubMed ID: 38626621

Doi: 10.1016/j.bbrc.2024.149934

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An emerging antibacterial nanovaccine for enhanced chemotherapy by selectively eliminating tumor-colonizing bacteria

Authors: Linfu Chen a, Zheyu Kang a, Jingjing Shen a, Rui Zhao a, Yu Miao a, Lin Zhang b, Zixuan Zheng c, Zhemin Zhang c, Nanhui Liu a, Cheng Wang a, Huapan Fang a, Jun Zhou a, Yudong Wang b, Zhuang Liu a, Yang Yang c, Qian Chen

Journal: Science Bulletin

Doi: doi.org/10.1016/j.scib.2024.06.016

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A full-length glycoprotein mRNA vaccine confers complete protection against severe fever with thrombocytopenia syndrome virus, with broad-spectrum protective effects against bandaviruses

Authors: Jia Lu, Jun Liu, Yan Wu, Xiaoxue He, Xiao Gao, Xinlan Chen, Shaoyi Chen, Xuerui Zhu, Yucai Peng, Gengfu Xiao, Xiaoyan Pan

Journal: J Virol

PubMed ID: 38829138

Doi: 10.1128/jvi.00769-24

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Evaluating the antibody response elicited by diverse HIV envelope immunogens in the African green monkey (Vervet) model

Authors: Thandeka Moyo-Gwete, Frances Ayres, Nonkululeko B Mzindle, Zanele Makhado, Nelia P Manamela, Simone I Richardson, Dale Kitchin, Strauss van Graan, Joritha van Heerden, Nishal Parbhoo, Gerald K Chege, Penny L Moore

Journal: Sci Rep

PubMed ID: 38858452

Doi: 10.1038/s41598-024-63703-7

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Hepatitis C virus NS5A and core protein induce fibrosis-related genes regulation on Huh7 cells through activation of LX2 cells

Authors: Tania G Heredia-Torres, Veronica Alvarado-Martínez, Ana R Rincon-Sanchez, Sonia A Lozano-Sepulveda, Kame Galan-Huerta, Daniel Arellanos-Soto, Ana M Rivas-Estilla

Journal: Ann Hepatol

PubMed ID: 38852781

Doi: 10.1016/j.aohep.2024.101517

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Sequence and structure analyses of lytic polysaccharide monooxygenases mined from metagenomic DNA of humus samples around white-rot fungi in Cuc Phuong tropical forest, Vietnam

Authors: Nam-Hai Truong, Thi-Thu-Hong Le, Hong-Duong Nguyen, Hong-Thanh Nguyen, Trong-Khoa Dao, Thi-Minh-Nguyet Tran, Huyen-Linh Tran, Dinh-Trong Nguyen, Thi-Quy Nguyen, Thi-Hong-Thao Phan, Thi-Huyen Do, Ngoc-Han Phan, Thi-Cam-Nhung Ngo, Van-Van Vu

Journal: PeerJ

PubMed ID: 38938609

Doi: 10.7717/peerj.17553

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nCas9 Engineering for Improved Target Interaction Presents an Effective Strategy to Enhance Base Editing

Authors: Guiquan Zhang, Ziguo Song, Shisheng Huang, Yafeng Wang, Jiayuan Sun, Lu Qiao, Guanglei Li, Yuanyuan Feng, Wei Han, Jin Tang, Yulin Chen, Xingxu Huang, Furui Liu, Xiaolong Wang, Jianghuai Liu

Journal: Adv Sci (Weinh)

PubMed ID: 38881503

Doi: 10.1002/advs.202405426

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Association between Bacteroides fragilis and Fusobacterium nucleatum infection and colorectal cancer in Vietnamese patients

Authors: Truong Nguyen Duy, Hoang Le Huy, Quyen Đao Thanh, Hoai Ngo Thi, Hanh Ngo Thi Minh, Manh Nguyen Dang, Song Le Huu, Trung Ngo Tat

Journal: Anaerobe

PubMed ID: 38942229

Doi: 10.1016/j.anaerobe.2024.102880

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