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A conserved protein inhibitor brings under check the activity of RNase E in cyanobacteria
Authors: Su-Juan Liu, Gui-Ming Lin, Yu-Qi Yuan, Wenli Chen, Ju-Yuan Zhang, Cheng-Cai Zhang
Journal: Nucleic Acids Res
PubMed ID: 38000383
Doi: 10.1093/nar/gkad1094
Pharmacokinetic Analyses of a Lipid Nanoparticle-Encapsulated mRNA-Encoded Antibody against Rift Valley Fever Virus
Authors: Shuo Wang, Ziling Zhu, Jianmin Li
Journal: Mol Pharm
PubMed ID: 38295278
Doi: 10.1021/acs.molpharmaceut.3c01016
Long chain capsaicin analogues synthetized by CALB-CLEAs show cytotoxicity on glioblastoma cell lines
Authors: Tania Diaz-Vidal, Vicente Paúl Armenta-Pérez, Luis Carlos Rosales-Rivera, Georgina Cristina Basulto-Padilla, Raúl Balam Martínez-Pérez, Juan Carlos Mateos-Díaz, Yanet K Gutiérrez-Mercado, Alejandro A Canales-Aguirre, Jorge A Rodríguez
Journal: Appl Microbiol Biotechnol
PubMed ID: 38217255
Doi: 10.1007/s00253-023-12856-y
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Functional characterization of the dimeric form of PDGF-derived fusion peptide fabricated based on theoretical arguments
Authors: Maryam Sadeghi-Ardebili, Sadegh Hasannia, Bahareh Dabirmanesh, Ramazan Ali Khavari-Nejad
Journal: Sci Rep
PubMed ID: 38200288
Doi: 10.1038/s41598-024-51707-2
Products & Services: Peptide Synthesis   
A small-molecule activation mechanism that directly opens the KCNQ2 channel
Authors: Shaoying Zhang, Demin Ma, Kun Wang, Ya Li, Zhenni Yang, Xiaoxiao Li, Junnan Li, Jiangnan He, Lianghe Mei, Yangliang Ye, Zongsheng Chen, Juwen Shen, Panpan Hou, Jiangtao Guo, Qiansen Zhang, Huaiyu Yang
Journal: Nat Chem Biol
PubMed ID: 38167918
Doi: 10.1038/s41589-023-01515-y
Products & Services: Gene Synthesis   
Ewing Sarcoma Related protein 1 recognizes R-loops by binding DNA forks
Authors: Michelle A Lay, Valery F Thompson, Ajibola D Adelakun, Jacob C Schwartz
Journal: biorxiv
PubMed ID: 38293191
Doi: 10.1101/2024.01.20.576463
Products & Services: Molecular Biology Reagents   
The adc1 knockout with proC overexpression in Synechocystis sp PCC 6803 induces a diversion of acetyl-CoA to produce more polyhydroxybutyrate
Authors: Suthira Utharn, Saowarath Jantaro
Journal: Biotechnol Biofuels Bioprod
PubMed ID: 38218963
Doi: 10.1186/s13068-024-02458-9
A glycoside hydrolase 30 protein BpXynC of Bacillus paralicheniformis NMSW12 recognized as A MAMP triggers plant immunity response
Authors: Chenjie Yu, Xiaoli Liang, Yan Song, Qurban Ali, Xihao Yang, Linli Zhu, Qin Gu, Vladislav Kuptsov, Emilia Kolomiets, Huijun Wu, Xuewen Gao
Journal: Int J Biol Macromol
PubMed ID: 38286384
Doi: 10.1016/j.ijbiomac.2024.129750
Products & Services: Mutant Libraries   
TMEM219 regulates the transcription factor expression and proliferation of beta cells
Authors: Francesca D'Addio, Emma Assi, Anna Maestroni, Giada Rossi, Vera Usuelli, Adriana Petrazzuolo, Marta Nardini, Cristian Loretelli, Moufida Ben Nasr, Paolo Fiorina
Journal: Front Endocrinol (Lausanne)
PubMed ID: 38318298
Doi: 10.3389/fendo.2024.1306127
Products & Services: ORF cDNA Clones/MolecularCloud   
A novel strategy for an anti-idiotype vaccine: nanobody mimicking neutralization epitope of porcine circovirus type 2
Authors: Yingying Deng, Yamin Sheng, Guixi Zhang, Yani Sun, Lei Wang, Pinpin Ji, Jiahong Zhu, Gang Wang, Baoyuan Liu, En-Min Zhou, Xuehui Cai, Yabin Tu, Julian A Hiscox, James P Stewart, Yang Mu, Qin Zhao
Journal: J Virol
PubMed ID: 38271227
Doi: 10.1128/jvi.01650-23
Improved detection sensitivity of anti-PRV variant antibodies through preparation of anti-gB and anti-gE monoclonal antibodies and development of blocking ELISAs
Authors: Zhenyang Guo, Hu Xu, Siyu Zhang, Haonan Kang, Chao Li, Qi Sun, Jing Zhao, Jinhao Li, Guohui Zhou, Qian Wang, Lirun Xiang, Yandong Tang, Huairan Liu, Chaoliang Leng, Tongqing An, Xuehui Cai, Zhijun Tian, Hongliang Zhang, Jinmei Peng
Journal: Int J Biol Macromol
PubMed ID: 38219937
Doi: 10.1016/j.ijbiomac.2024.129425
ETHYLENE RESPONSE FACTOR 070 inhibits flowering in Pak-choi by indirectly impairing BcLEAFY expression
Authors: Zhanghong Yu , Xiaoshan Chen , Yan Li , Sayyed Hamad Ahmad Shah , Dong Xiao , Jianjun Wang , Xilin Hou , Tongkun Liu , Ying Li
Journal: Plant Physiol .
PubMed ID: 38269601
Doi: 10.1093/plphys/kiae021
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Lipopolysaccharides from a Shiraia fruiting body-associated bacterium elicit host fungal hypocrellin A biosynthesis through nitric oxide generation
Authors: Xin Ping Li , Wen Hao Shen , Lu Lu Zhou , Qun Yan Huang , Rui Peng Cong , Li Ping Zheng , Jian Wen Wang
Journal: Carbohydr Polym .
PubMed ID: 37985049
Doi: 10.1016/j.carbpol.2023.121498.
Synovial sarcoma X breakpoint 1 protein uses a cryptic groove to selectively recognize H2AK119Ub nucleosomes
Authors: Zebin Tong , Huasong Ai, Ziyu Xu , Kezhang He , Guo-Chao Chu, Qiang Shi , Zhiheng Deng, Qiaomei Xue , Maoshen Sun, Yunxiang Du , Lujun Liang, Jia-Bin Li , Man Pan , Lei Liu
Journal: Nat Struct Mol Biol .
PubMed ID: 38177667
Doi: 10.1038/s41594-023-01141-1
Inhaled nanoparticles for treating idiopathic pulmonary fibrosis by inhibiting honeycomb cyst and alveoli interstitium remodeling
Authors: Meng-Meng Han , Ling Tang , Bin Huang , Xue-Na Li , Yue-Fei Fang , Liang Qi , Bo-Wen Duan , Ya-Ting Yao , Yu-Jing He , Lei Xing , Hu-Lin Jiang
Journal: J Control Release .
PubMed ID: 38242209
Doi: 10.1016/j.jconrel.2024.01.032
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Regulation of RAS palmitoyltransferases by accessory proteins and palmitoylation
Authors: Anlan Yang , Shengjie Liu , Yuqi Zhang , Jia Chen , Yujing Fan , Fengxiang Wang , Yilong Zou , Shan Feng , Jianping Wu , Qi Hu
Journal: Nat Struct Mol Biol .
PubMed ID: 38182928
Doi: 10.1038/s41594-023-01183-5
Disordered-to-ordered transitions in assembly factors allow the complex II catalytic subunit to switch binding partners
Authors: Pankaj Sharma, Elena Maklashina, Markus Voehler, Sona Balintova , Sarka Dvorakova, Michal Kraus, Katerina Hadrava Vanova Zuzana Nahacka, Renata Zobalova, Stepana Boukalova, Kristyna Cunatova, Tomas Mracek, Hans K Ghayee, Karel Pacak, Jakub Rohlena, Jiri Neuzil, Gary Cecchini,T M Iverson
Journal: Nat Commun
PubMed ID: 38212624
Doi: 10.1038/s41467-023-44563-7
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MARS an improved de novo peptide candidate selection method for non-canonical antigen target discovery in cancer
Authors: Hanqing Liao , Carolina Barra , Zhicheng Zhou , Xu Peng , Isaac Woodhouse , Arun Tailor , Robert Parker , Alexia Carré , Persephone Borrow , Michael J Hogan , Wayne Paes , Laurence C Eisenlohr , Roberto Mallone , Morten Nielsen , Nicola Ternette
Journal: Nat Commun
PubMed ID: 38253617
Doi: 10.1038/s41467-023-44460-z
Products & Services: Peptide Synthesis   
The role of CD38 in inflammation-induced depression-like behavior and the antidepressant effect of (R)-ketamine
Authors: Xinying Zhang a , Teng He a , Zifeng Wu a , Yuanyuan Wang a, Hanyu Liu a, Bingyuan Zhang a, Siqi Yang a, Di Wang a, Chaoli Huang a, Jiahao Duan b, Xiangyang Xu c, Xiangqing Xu c, Kenji Hashimoto d, Riyue Jiang e, Ling Yang b, Chun Yang
Journal: Brain, behavior, and immunity
PubMed ID: 37793489
Doi: 10.1016/j.bbi.2023.09.026
Products & Services: Gene Synthesis   
Acylspermidines are conserved mitochondrial sirtuin-dependent metabolites
Authors: Bingsen Zhang, James Mullmann, Andreas H. Ludewig, Irma R. Fernandez, Tyler R. Bales, Robert S. Weiss & Frank C. Schroeder
Journal: Nature Chemical Biology
PubMed ID: 38167917
Doi: 10.1038/s41589-023-01511-2
Omicron Spike confers enhanced infectivity and interferon resistance to SARS-CoV-2 in human nasal tissue
Authors: Guoli Shi , Tiansheng Li , Kin Kui Lai , Reed F Johnson , Jonathan W Yewdell , Alex A Compton
Journal: Nat Commun
PubMed ID: 38291024
Doi: 10.1038/s41467-024-45075-8
Products & Services: PCR Cloning and Subcloning   
The role of the Toll like receptor 4 signaling in sex-specific persistency of depression-like behavior in response to chronic stress
Authors: Eun-Jeong Yang , Tal Frolinger , Umar Iqbal , Molly Estill , Li Shen , Kyle J Trageser , Giulio M Pasinetti
Journal: Brain, behavior, and immunity
PubMed ID: 37838079
Doi: 10.1016/j.bbi.2023.10.006
Products & Services: Gene Synthesis   
Role of UPF1-LIN28A interaction during early differentiation of pluripotent stem cells
Authors: Seungwon Jung , Seung Hwan Ko , Narae Ahn , Jinsam Lee , Chang-Hwan Park , Jungwook Hwang
Journal: Nat Commun
PubMed ID: 38167913
Doi: 10.1038/s41467-023-44600-5
Products & Services: Polyclonal Antibody Services   
CI:Mor interactions in the lysogeny switches of TP901-1 and φ13 bacteriophages
Authors: Anders K Varming, Zhiyu Huang, Ghofran M Hamad, Kim K Rasmussen, Hanne Ingmer, Mogens Kilstrup, Leila Lo Leggio
Journal: Microbiome Res Rep
PubMed ID: 38841409
Doi: 10.20517/mrr.2023.50
Products & Services: Gene Synthesis   
IGF-I protects porcine granulosa cells from hypoxia-induced apoptosis by promoting homologous recombination repair through the PI3K/AKT/E2F8/RAD51 pathway
Authors: Zhaojun Liu, Chungang Feng, Chengyu Li, Tong He, Gang Wu, Chen Fu, Hongmin Li, Ming Shen, Honglin Liu
Journal: FASEB J
PubMed ID: 38095232
Doi: 10.1096/fj.202301464R
Engineering of Ogataea polymorpha strains with ability for high-temperature alcoholic fermentation of cellobiose
Authors: Roksolana Vasylyshyn, Olena Dmytruk, Andriy Sybirnyy, Justyna Ruchała
Journal: FEMS Yeast Res
PubMed ID: 38400543
Doi: 10.1093/femsyr/foae007
Products & Services: Gene Synthesis   
Assessment of the effectiveness of the peptide inhibitor homologous to the transforming growth factor β cytokine blocking the TGFβRI/TGFβRII receptor complex-pilot study
Authors: Marynowski Mateusz, Karbownik Michał Seweryn, Szemraj Janusz, Kuna Piotr, Michał Gabriel Panek
Journal: Clin Transl Allergy
PubMed ID: 38282199
Doi: 10.1002/clt2.12320
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Cell death induced by nicotine in human neuroblastoma SH-SY5Y cells is mainly attributed to cytoplasmic vacuolation originating from the trans-Golgi network
Authors: Jun Li, Hongjuan Wang, Huan Chen, Xiao Li, Yong Liu, Hongwei Hou, Qingyuan Hu
Journal: Food Chem Toxicol
PubMed ID: 38176581
Doi: 10.1016/j.fct.2023.114431
FLUAV RAM-IGIP: A modified live influenza virus vaccine that enhances humoral and mucosal responses against influenza
Authors: C Joaquín Cáceres, L Claire Gay, Aarti Jain, Teresa D Mejías, Matias Cardenas, Brittany Seibert, Flavio Cargnin Faccin, Brianna Cowan, Ginger Geiger, Amy Vincent Baker, Silvia Carnaccini, D Huw Davies, Daniela S Rajao, Daniel R Perez
Journal: biorxiv
PubMed ID: 38328128
Doi: 10.1101/2024.01.23.576908
Products & Services: PCR Cloning and Subcloning   
FLT3L-induced virtual memory CD8 T cells engage the immune system against tumors
Authors: Hsin-Fang Tu, Yu-Jui Kung, Ling Lim, Julia Tao, Ming-Hung Hu, Michelle Cheng, Deyin Xing, T C Wu, Chien-Fu Hung
Journal: J Biomed Sci
PubMed ID: 38287325
Doi: 10.1186/s12929-024-01006-9
Products & Services: PCR Cloning and Subcloning   
Structural, Biochemical, and Bioinformatic Basis for Identifying Radical SAM Cyclopropyl Synthases
Authors: Yi Lien, Jake C Lachowicz, Aigera Mendauletova, Cynthia Zizola, Thacien Ngendahimana, Anastasiia Kostenko, Sandra S Eaton, John A Latham, Tyler L Grove
Journal: ACS Chem Biol
PubMed ID: 38295270
Doi: 10.1021/acschembio.3c00583
Products & Services: Gene Synthesis   
Human microbiota from drug-naive patients with obsessive-compulsive disorder drives behavioral symptoms and neuroinflammation via succinic acid in mice
Authors: Ying-Dan Zhang, Dong-Dong Shi, Bing-Bing Liao, Yi Li, Sen Zhang, Jian Gao, Liang-Jun Lin, Zhen Wang
Journal: Mol Psychiatry
PubMed ID: 38273106
Doi: 10.1038/s41380-024-02424-9
Rescue of secretion of rare-disease-associated misfolded mutant glycoproteins in UGGT1 knock-out mammalian cells
Authors: Gabor Tax, Kevin P Guay, Ludovica Pantalone, Martina Ceci, Tatiana Soldà, Charlie J Hitchman, Johan C Hill, Snežana Vasiljević, Andrea Lia, Carlos P Modenutti, Kees R Straatman, Angelo Santino, Maurizio Molinari, Nicole Zitzmann, Daniel N Hebert, Pietro Roversi, Marco Trerotola
Journal: Traffic
PubMed ID: 38272446
Doi: 10.1111/tra.12927
Products & Services: Mutagenesis Services   
GhUBC10-2 mediates GhGSTU17 degradation to regulate salt tolerance in cotton (Gossypium hirsutum)
Authors: Yaru Sun, Zailong Tian, Dongyun Zuo, Qiaolian Wang, Guoli Song
Journal: Plant Cell Environ
PubMed ID: 38282268
Doi: 10.1111/pce.14839
Products & Services: PCR Cloning and Subcloning   
Systemic effects of hypophosphatasia characterization of two novel variants in the gene
Authors: Luis Martínez-Heredia, Manuel Muñoz-Torres, Raquel Sanabria-de la Torre, Ángela Jiménez-Ortas, Francisco Andújar-Vera, Trinidad González-Cejudo, Victoria Contreras-Bolívar, Sheila González-Salvatierra, José María Gómez-Vida, Cristina García-Fontana, Beatriz García-Fontana
Journal: Front Endocrinol (Lausanne)
PubMed ID: 38234425
Doi: 10.3389/fendo.2023.1320516
Products & Services: Molecular Biology Reagents   
Transition Metal Ion FRET-Based Probe to Study Cu(II)-Mediated Amyloid- Ligand Binding
Authors: Ri Wu, Despoina Svingou, Jonas B Metternich, Lukas R Benzenberg, Renato Zenobi
Journal: J Am Chem Soc
PubMed ID: 38225538
Doi: 10.1021/jacs.3c11533
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Effect of l-serine and magnesium ions on the functional properties of human phosphoserine phosphatase and its pathogenetic variants
Authors: Francesco Marchesani, Valeria Buoli Comani, Stefano Bruno, Andrea Mozzarelli, Mauro Carcelli, Loredano Pollegioni, Laura Caldinelli, Alessio Peracchi, Barbara Campanini
Journal: Biochim Biophys Acta Mol Basis Dis
PubMed ID: 38278334
Doi: 10.1016/j.bbadis.2024.167034
Products & Services: Mutagenesis Services   
Production of anti-human cannabinoid receptor 2 (CB2) monoclonal antibody using non-viral vector induced human CB2 expressing myeloma as an immunogen
Authors: Jindaphun Kanyaruck, Takheaw Nuchjira, Putpim Chaochetdhapada, Laopajon Witida, Kotemul Kamonporn, Chaiwut Ratthakorn, Pata Supansa, Kasinrerk Watchara
Journal: Asian Pac J Allergy Immunol
PubMed ID: 38183645
Doi: 10.12932/AP-020723-1646
Products & Services: Molecular Biology Reagents   
The Anti-SARS-CoV-2 IgG1 and IgG3 Antibody Isotypes with Limited Neutralizing Capacity against Omicron Elicited in a Latin Population a Switch toward IgG4 after Multiple Doses with the mRNA Pfizer-BioNTech Vaccine
Authors: Ana M Espino, Albersy Armina-Rodriguez, Laura Alvarez, Carlimar Ocasio-Malavé, Riseilly Ramos-Nieves, Esteban I Rodriguez Martinó, Paola López-Marte, Esther A Torres, Carlos A Sariol
Journal: Viruses
PubMed ID: 38399963
Doi: 10.3390/v16020187
Products & Services: Molecular Biology Reagents   
BBS genes are involved in accelerated proliferation and early differentiation of BBS-related tissues
Authors: Avital Horwitz, Noa Levi-Carmel, Olga Shnaider, Ruth Birk
Journal: Differentiation
PubMed ID: 38215537
Doi: 10.1016/j.diff.2024.100745
Products & Services: Molecular Biology Reagents   
Cytoophidia Influence Cell Cycle and Size in
Authors: Ruolan Deng, Yi-Lan Li, Ji-Long Liu
Journal: Int J Mol Sci
PubMed ID: 38203781
Doi: 10.3390/ijms25010608
Endolysin NC5 improves early cloxacillin treatment in a mouse model of Streptococcus uberis mastitis
Authors: Niels Vander Elst, Julie Bellemans, Rob Lavigne, Yves Briers, Evelyne Meyer
Journal: Appl Microbiol Biotechnol
PubMed ID: 38204128
Doi: 10.1007/s00253-023-12820-w
Products & Services: Molecular Biology Reagents   
Irreversible light-activated SpyLigation mediates split-protein assembly in 4D
Authors: Brizzia G Munoz-Robles, Cole A DeForest
Journal: Nat Protoc
PubMed ID: 38253657
Doi: 10.1038/s41596-023-00938-0
Blocking the E2F transcription factor 1/high-mobility group box 2 pathway enhances the intervention effects of α-santalol on the malignant behaviors of liver cancer cells
Authors: Hui Wang, Min Tang, Erli Pei, Ying Shen, Aili Wang, Moubin Lin
Journal: Int J Biochem Cell Biol
PubMed ID: 38219975
Doi: 10.1016/j.biocel.2024.106516
Biosynthesis of 10-Hydroxy-2-decenoic Acid through a One-Step Whole-Cell Catalysis
Authors: Ke Fang , Ziting Xu , Lu Yang , Quan Cui , Bowen Du , Huijing Liu , Ruiming Wang , Piwu Li , Jing Su , Junqing Wang
Journal: J Agric Food Chem .
PubMed ID: 38175798
Doi: 10.1021/acs.jafc.3c08142
Products & Services: Gene Synthesis   
Let-7a-5p Regulates Animal Lipid Accumulation by Targeting Srebf2 and Thbs1 Signaling
Authors: Jiahao Shao , Genglong Jiang , Yanhong Li, Meigui Wang, Tao Tang, Jie Wang , Xianbo Jia and Songjia Lai
Journal: Int. J. Mol. Sci
Doi: 10.3390/ijms25020894
PIEZO1 loss-of-function compound heterozygous mutations in the rare congenital human disorder Prune Belly Syndrome
Authors: Nathalia G Amado , Elena D Nosyreva , David Thompson , Thomas J Egeland , Osita W Ogujiofor , Michelle Yang , Alexandria N Fusco , Niccolo Passoni , Jeremy Mathews , Brandi Cantarel , Linda A Baker , Ruhma Syeda
Journal: Nat Commun
PubMed ID: 38184690
Doi: 10.1038/s41467-023-44594-0
Products & Services: PCR Cloning and Subcloning   
A stapled lipopeptide platform for preventing and treating highly pathogenic viruses of pandemic potential
Authors: Gregory H Bird , J J Patten , William Zavadoski , Nicole Barucci , Marina Godes , Benjamin M Moyer , Callum D Owen , Paul DaSilva-Jardine , Donna S Neuberg , Richard A Bowen , Robert A Davey , Loren D Walensky
Journal: Nat Commun
PubMed ID: 38177138
Doi: 10.1038/s41467-023-44361-1
Products & Services: Plasmid DNA Preparation   
Correlations of receptor desensitization of gain-of-function GABRB3 variants with clinical severity
Authors: Susan X N Lin, Philip K Ahring, Angelo Keramidas, Vivian W Y Liao, Rikke S Møller, Mary Chebib, Nathan L Absalom
Journal: Brain
PubMed ID: 37647766
Doi: 10.1093/brain/awad285
Products & Services: Plasmid DNA Preparation   
Massively parallel profiling of RNA-targeting CRISPR-Cas13d
Authors: Hung-Che Kuo , Joshua Prupes , Chia-Wei Chou , Ilya J Finkelstein
Journal: Nat Commun
PubMed ID: 37034598
Doi: 10.1101/2023.03.27.534188
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