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Design and development of multiepitope chimeric antigens by bioinformatic and bacterial based recombinant expression methods, with potential application for bovine tuberculosis serodiagnosis

Authors: Cassiano Martin Batista, Josir Laine Veschi, Vanessa Felipe de Souza, Leonardo Foti, Lea Chapaval Andri

Journal: Vet Immunol Immunopathol

PubMed ID: 38377627

Doi: 10.1016/j.vetimm.2024.110729

Products & Services: Molecular Biology Reagents

Functional analyses of TRAF6 gene in Argopecten scallops

Authors: Xiaotong Zhang, Xia Wang, Jieyu Chen, Min Chen, Xia Lu, Junhao Ning, Haijun Liu, Guilong Liu, Xin Xu, Xiaoxu Qu, Kai Yu, He Xu, Chunde Wang, Bo Liu

Journal: Fish Shellfish Immunol

PubMed ID: 38354964

Doi: 10.1016/j.fsi.2024.109443

Products & Services: PCR Cloning and Subcloning

Deficiency in PHD2-mediated hydroxylation of HIF2α underlies Pacak-Zhuang syndrome

Authors: Fraser G Ferens, Cassandra C Taber, Sarah Stuart, Mia Hubert, Daniel Tarade, Jeffrey E Lee, Michael Ohh

Journal: Commun Biol

PubMed ID: 38418569

Doi: 10.1038/s42003-024-05904-4

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Comparison of Cas12a and Cas9-mediated mutagenesis in tomato cells

Authors: Ellen Slaman, Lisanne Kottenhagen, William de Martines, Gerco C Angenent, Ruud A de Maagd

Journal: Sci Rep

PubMed ID: 38402312

Doi: 10.1038/s41598-024-55088-4

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Crossprotection induced by virus-like particles containing influenza dual-hemagglutinin and M2 ectodomain

Authors: Jie Mao, Gi-Deok Eom, Keon-Woong Yoon, Min-Ju Kim, Ki-Back Chu, Hae-Ji Kang, Fu-Shi Quan

Journal: Nanomedicine (Lond)

PubMed ID: 38390688

Doi: 10.2217/nnm-2023-0353

Products & Services: Gene Synthesis

Pharmacogenomics of poor drug metabolism in greyhounds: Canine P450 oxidoreductase genetic variation, breed heterogeneity, and functional characterization

Authors: Stephanie E Martinez, Amit V Pandey, Tania E Perez Jimenez, Zhaohui Zhu, Michael H Court

Journal: PLoS ONE

PubMed ID: 38300925

Doi: 10.1371/journal.pone.0297191

Products & Services: Mutagenesis Services

Establishment of a Dual-Vector System for Gene Delivery Utilizing Prototype Foamy Virus

Authors: Soo-Yeon Cho, Yoon Jae Lee, Seong-Mook Jung, Young Min Son, Cha-Gyun Shin, Eui Tae Kim, Kyoung-Dong Kim

Journal: J Microbiol Biotechnol

PubMed ID: 38379304

Doi: 10.4014/jmb.2312.12026

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A diffusible small-RNA-based Turing system dynamically coordinates organ polarity

Authors: Emanuele Scacchi, Gael Paszkiewicz, Khoa Thi Nguyen, Shreyas Meda, Agata Burian, Walter de Back, Marja C P Timmermans

Journal: Nat Plants

PubMed ID: 38409292

Doi: 10.1038/s41477-024-01634-x

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Critical Aggregation Concentration Can be a Predictor of Doxorubicin Delivery Performance of Self-Assembling Amphiphilic Peptides with Different Hydrophobic Tails

Authors: Saeed Zanganeh, Loghman Firoozpour, Maryam Samareh Salavatipour, Soroush Sardari, Reza Ahangari Cohan, Nasir Mohajel

Journal: J Pharm Sci

PubMed ID: 38417791

Doi: 10.1016/j.xphs.2024.02.022

Products & Services: Proteins, Expression, Isolation and Analysis

Long-Term Dynamic Changes in Hybrid Immunity over Six Months after Inactivated and Adenoviral Vector Vaccination in Individuals with Previous SARS-CoV-2 Infection

Authors: Nungruthai Suntronwong, Sitthichai Kanokudom, Chompoonut Auphimai, Thanunrat Thongmee, Suvichada Assawakosri, Preeyaporn Vichaiwattana, Ritthideach Yorsaeng, Thaneeya Duangchinda, Warangkana Chantima, Pattarakul Pakchotanon, Pornjarim Nilyanimit, Donchida Srimuan, Thaksaporn Thatsanathorn, Natthinee Sudhinaraset, Nasamon Wanlapakorn, Yong Poovorawan

Journal: Vaccines (Basel)

PubMed ID: 38400163

Doi: 10.3390/vaccines12020180

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A Divalent Chikungunya and Zika Nanovaccine with Thermostable Self-Assembly Multivalent Scaffold LS-SUMO

Authors: Qianlin Li, Jinsong Zhang, Qiang Deng, Conghui Liao, Jun Qian, Zeliang Chen, Jiahai Lu

Journal: Adv Healthc Mater

PubMed ID: 38340040

Doi: 10.1002/adhm.202303619

Products & Services: Molecular Biology Reagents

Involvement of a catalase gene in lignin catalysis and immune defense against pathogenic fungus in Coptotermes formosanus: a potential new target for termite control

Authors: Wenhui Zeng, Danni Shen, Wenjing Wu, Shijun Zhang, Zhiqiang Li, Dandan Zhang

Journal: Pest Manag Sci

PubMed ID: 38358092

Doi: 10.1002/ps.8029

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Deciphering the origin of developmental stability: The role of intracellular expression variability in evolutionary conservation

Authors: Yui Uchida, Masato Tsutsumi, Shunsuke Ichii, Naoki Irie, Chikara Furusawa

Journal: Evol Dev

PubMed ID: 38414112

Doi: 10.1111/ede.12473

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Inhibition of Aurora Kinase Induces Endogenous Retroelements to Induce a Type I/III IFN Response via RIG-I

Authors: Lisa Choy, Stephen Norris, Xiumin Wu, Ganesh Kolumam, Ari Firestone, Jeffrey Settleman, David Stokoe

Journal: Cancer Res Commun

PubMed ID: 38358346

Doi: 10.1158/2767-9764.CRC-23-0432

Products & Services: Codon Optimization

CRIP1 involves the pathogenesis of multiple myeloma via dual-regulation of proteasome and autophagy

Authors: Peixia Tang , Zhen Yu , Hao Sun 2, Lanting Liu , Lixin Gong , Teng Fang , Xiyue Sun , Shiyi Xie , Gang An 2, Zhenshu Xu 3, Lugui Qiu 4, Mu Hao

Journal: EBioMedicine

PubMed ID: 38199044

Doi: 10.1016/j.ebiom.2023.104961

Products & Services: Proteins, Expression, Isolation and Analysis

Heterotypic interactions can drive selective co-condensation of prion-like low-complexity domains of FET proteins and mammalian SWI/SNF complex

Authors: Richoo B Davis, Anushka Supakar, Aishwarya Kanchi Ranganath, Mahdi Muhammad Moosa, Priya R Banerjee

Journal: Nature Communications

PubMed ID: 38326345

Doi: 10.1038/s41467-024-44945-5

Products & Services: Molecular Biology Reagents Gene Synthesis

Increasing β-hexosaminidase A activity using genetically modified mesenchymal stem cells

Authors: Alisa A Shaimardanova , Daria S Chulpanova , Valeriya V Solovyeva 1, Shaza S Issa , Aysilu I Mullagulova , Angelina A Titova , Yana O Mukhamedshina , Anna V Timofeeva , Alexander M Aimaletdinov , Islam R Nigmetzyanov , Albert A Rizvanov

Journal: Neural Regen Res .

PubMed ID: 37488869

Doi: 10.4103/1673-5374.375328

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Minimalist Nanovaccine with Optimized Amphiphilic Copolymers for Cancer Immunotherapy

Authors: Le Niu , Yu Miao , Zhiqin Cao , Ting Wei , Jiafei Zhu , Maoyi Li , Boxiong Bai , Linfu Chen , Nanhui Liu , Feng Pan , Junjie Zhu , Cheng Wang , Yang Yang , Qian Chen

Journal: ACS Nano .

PubMed ID: 38230639

Doi: 10.1021/acsnano.3c10174

Products & Services: Peptide Synthesis

Collaborative regulation of yeast SPT-Orm2 complex by phosphorylation and ceramide

Authors: Tian Xie , Feitong Dong , Gongshe Han , Xinyue Wu , Peng Liu , Zike Zhang , Jianlong Zhong , Somashekarappa Niranjanakumari , Kenneth Gable , Sita D Gupta , Wenchen Liu , Peter J Harrison , Dominic J Campopiano , Teresa M Dunn , Xin Gong

Journal: Cell Rep .

PubMed ID: 38285738

Doi: 10.1016/j.celrep.2024.113717

Products & Services: Proteins, Expression, Isolation and Analysis

Supramolecular Hydrogel with Ultra-Rapid Cell-Mediated Network Adaptation for Enhancing Cellular Metabolic Energetics and Tissue Regeneration

Authors: Zhuo Li, Boguang Yang, Zhengmeng Yang, Xian Xie, Zhengnan Guo, Jianyang Zhao, Ruinan Wang, Hao Fu, Pengchao Zhao, Xin Zhao, Guosong Chen, Gang Li, Fuxin Wei, Liming Bian

Journal: Adv Mater .

PubMed ID: 38295393

Doi: 10.1002/adma.202307176

Products & Services: Peptide Synthesis

TREM2 variants that cause early dementia and increase Alzheimer's disease risk affect gene splicing

Authors: Kostantin Kiianitsa, Maria E Lukes, Brian J Hayes, Julianna Brutman, Paul N Valdmanis, Thomas D Bird, Wendy H Raskind, Olena Korvatska

Journal: Brain

PubMed ID: 38226698

Doi: 10.1093/brain/awae014

Products & Services: Gene Synthesis Mutagenesis Services Plasmid DNA Preparation

mRNA vaccines against SARS-CoV-2 induce divergent antigen-specific T-cell responses in patients with lung cancer

Authors: No-Joon Song, Karthik B Chakravarthy, Hyeongseon Jeon, Chelsea Bolyard, Kelsi Reynolds, Kevin P Weller, Sarah Reisinger, Yi Wang, Anqi Li, Sizun Jiang, Qin Ma, Dan H Barouch, Mark P Rubinstein, Peter G Shields, Eugene M Oltz, Dongjun Chung, Zihai Li

Journal: J Immunother Cancer

PubMed ID: 38177076

Doi: 10.1136/jitc-2023-007922

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Microglia-derived exosomes modulate myelin regeneration via miR-615-5p/MYRF axis

Authors: Xiao-Yu Ji, Yu-Xin Guo, Li-Bin Wang, Wen-Cheng Wu, Jia-Qi Wang, Jin He, Rui Gao, Javad Rasouli, Meng-Yuan Gao, Zhen-Hai Wang, Dan Xiao, Wei-Feng Zhang, Bogoljub Ciric, Yuan Zhang, Xing Li

Journal: J Neuroinflammation

PubMed ID: 38246987

Doi: 10.1186/s12974-024-03019-5

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A CRISPR-Cas12a-based electrochemical biosensor for the detection of microphthalmia-associated transcription factor

Authors: Qisheng Luo, Chunyuan Zhang, Xiandong Deng, Dongyuan Liu, Xingchen Pan, Yuanxun Gong, Qianli Tang, Kai Zhang, Xianjiu Liao

Journal: Mikrochim Acta

PubMed ID: 38170285

Doi: 10.1007/s00604-023-06164-5

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Cognitive impairment is associated with BDNF-TrkB signaling mediating synaptic damage and reduction of amino acid neurotransmitters in heart failure

Authors: Lei Wang, Ziwen Lu, Yu Teng, Weibing Pan, Yang Li, Sha Su, Jingling Chang, Mingjing Zhao

Journal: FASEB J

PubMed ID: 38085181

Doi: 10.1096/fj.202301699RR

Products & Services: Proteins, Expression, Isolation and Analysis

Fragment-based screening targeting an open form of the SARS-CoV-2 main protease binding pocket

Authors: Chia Ying Huang, Alexander Metz, Roland Lange, Nadia Artico, Céline Potot, Julien Hazemann, Manon Müller, Marina Dos Santos, Alain Chambovey, Daniel Ritz, Deniz Eris, Solange Meyer, Geoffroy Bourquin, May Sharpe, Aengus Mac Sweeney

Journal: Acta Crystallogr D Struct Biol

PubMed ID: 38289714

Doi: 10.1107/S2059798324000329

Products & Services: Proteins, Expression, Isolation and Analysis

Structural basis of prostaglandin efflux by MRP4

Authors: Sergei Pourmal, Evan Green, Ruchika Bajaj, Ilan E Chemmama, Giselle M Knudsen, Meghna Gupta, Andrej Sali, Yifan Cheng, Charles S Craik, Deanna L Kroetz, Robert M Stroud

Journal: Nat Struct Mol Biol

PubMed ID: 38216659

Doi: 10.1038/s41594-023-01176-4

Products & Services: Mutant Libraries

Beta-1,3-Glucan-Binding Protein Inhibits Dengue and ZIKA Virus Replication

Authors: Xiaoxue Xie, Di Wang, Bo Li, Guorui Liang, Xiaoli Chen, Dan Xing, Teng Zhao, Xinyu Zhou, Chunxiao Li

Journal: Biomedicines

PubMed ID: 38255195

Doi: 10.3390/biomedicines12010088

Products & Services: DNA Sequencing

Increasing the Pentose Phosphate Pathway Flux to Improve Plasmid DNA Production in Engineered

Authors: Mitzi de la Cruz, Flavio Kunert, Hilal Taymaz-Nikerel, Juan-Carlos Sigala, Guillermo Gosset, Jochen Büchs, Alvaro R Lara

Journal: Microorganisms

PubMed ID: 38257977

Doi: 10.3390/microorganisms12010150

Products & Services: Molecular Biology Reagents

Identification and application of an exocarp-preferential promoter for genetic engineering of tomato fruit

Authors: Xue-Ming Ruan, Xiangyu Xiong, Jian-Feng Li

Journal: Hortic Res

PubMed ID: 38544552

Doi: 10.1093/hr/uhae035

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Cluster-Enhanced Nanopore Sensing of Ovarian Cancer Marker Peptides in Urine

Authors: Thomas W Rockett, Mohammed Almahyawi, Madhav L Ghimire, Aashna Jonnalagadda, Victoria Tagliaferro, Sarah J Seashols-Williams, Massimo F Bertino, Gregory A Caputo, Joseph E Reiner

Journal: ACS Sens

PubMed ID: 38286995

Doi: 10.1021/acssensors.3c02207

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Combined biolistic and cell penetrating peptide delivery for the development of scalable intradermal DNA vaccines

Authors: Roizza Beth So, Gang Li, Victoria Brentville, Janet M Daly, James E Dixon

Journal: J Control Release

PubMed ID: 38244841

Doi: 10.1016/j.jconrel.2024.01.031

Products & Services: Proteins, Expression, Isolation and Analysis

Therapeutic effect of long-acting FGF21 with controlled site-specific modification on nonalcoholic steatohepatitis

Authors: Jianying Qi, Zhimou Guo, Shenglong Zhu, Xuan Jiang, Yuanyuan Wu, Yingli Chen, Fei Hu, Jingjing Xiong, YunZhou Wu, Xianlong Ye, Xinmiao Liang

Journal: Int J Biol Macromol

PubMed ID: 38290625

Doi: 10.1016/j.ijbiomac.2024.129797

Products & Services: Molecular Biology Reagents

Oleuropein-driven reprogramming of the myeloid cell compartment to sensitise tumours to PD-1/PD-L1 blockade strategies

Authors: Ester Blanco, Noelia Silva-Pilipich, Ana Bocanegra, Luisa Chocarro, Antonio Procopio, Karina Ausín, Joaquín Fernandez-Irigoyen, Leticia Fernández, Nerea Razquin, Ana Igea, Maider Garnica, Miriam Echaide, Hugo Arasanz, Ruth Vera, David Escors, Cristian Smerdou, Grazyna Kochan

Journal: Br J Cancer

PubMed ID: 38195888

Doi: 10.1038/s41416-023-02561-y

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Glyoxylate reductase: Definitive identification in human liver mitochondria, its importance for the compartment-specific detoxification of glyoxylate

Authors: Sander F Garrelfs, Serhii Chornyi, Heleen Te Brinke, Jos Ruiter, Jaap Groothoff, Ronald J A Wanders

Journal: J Inherit Metab Dis

PubMed ID: 38200664

Doi: 10.1002/jimd.12711

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Non-canonical antigens are the largest fraction of peptides presented by MHC class I in mismatch repair deficient murine colorectal cancer

Authors: Giuseppe Rospo, Rosaria Chilà, Vittoria Matafora, Veronica Basso, Simona Lamba, Alice Bartolini, Angela Bachi, Federica Di Nicolantonio, Anna Mondino, Giovanni Germano, Alberto Bardelli

Journal: Genome Med

PubMed ID: 38243308

Doi: 10.1186/s13073-023-01275-3

Products & Services: Proteins, Expression, Isolation and Analysis

Hepatitis C virus E1 recruits high-density lipoprotein to support infectivity and evade antibody recognition

Authors: Jennifer Casiano Matos, Kaneemozhe Harichandran, Jingrong Tang, Denis O Sviridov, Giacomo Sidoti Migliore, Motoshi Suzuki, Lisa R Olano, Alvaro Hobbs, Ashish Kumar, Myeisha U Paskel, Mattia Bonsignori, Altaira D Dearborn, Alan T Remaley, Joseph Marcotrigiano

Journal: J Virol

PubMed ID: 38174935

Doi: 10.1128/jvi.00849-23

Products & Services: Proteins, Expression, Isolation and Analysis

The lncRNA HCG4 regulates the RIG-I-mediated IFN production to suppress H1N1 swine influenza virus replication

Authors: Jinghua Cheng, Jie Tao, Benqiang Li, Ying Shi, Huili Liu

Journal: Front Microbiol

PubMed ID: 38274760

Doi: 10.3389/fmicb.2023.1324218

Products & Services: Proteins, Expression, Isolation and Analysis

Predicting multiple conformations via sequence clustering and AlphaFold2

Authors: Hannah K Wayment-Steele, Adedolapo Ojoawo, Renee Otten, Julia M Apitz, Warintra Pitsawong, Marc Hömberger, Sergey Ovchinnikov, Lucy Colwell, Dorothee Kern

Journal: Nature

PubMed ID: 37956700

Doi: 10.1038/s41586-023-06832-9

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N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting

Authors: Thomas E Mulroney, Tuija Pöyry, Juan Carlos Yam-Puc, Maria Rust, Robert F Harvey, Lajos Kalmar, Emily Horner, Lucy Booth, Alexander P Ferreira, Mark Stoneley, Ritwick Sawarkar, Alexander J Mentzer, Kathryn S Lilley, C Mark Smales, Tobias von der Haar, Lance Turtle, Susanna Dunachie, Paul Klenerman, James E D Thaventhiran, Anne E Willis

Journal: Nature

PubMed ID: 38057663

Doi: 10.1038/s41586-023-06800-3

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Diverse array of neutralizing antibodies elicited upon Spike Ferritin Nanoparticle vaccination in rhesus macaques

Authors: Rajeshwer S Sankhala , Kerri G Lal , Jaime L Jensen , Vincent Dussupt , Letzibeth Mendez-Rivera , Hongjun Bai , Lindsay Wieczorek , Sandra V Mayer , Michelle Zemil , Danielle A Wagner , Samantha M Townsley , Agnes Hajduczki , William C Chang , Wei-Hung Chen , Gina C Donofrio , Ningbo Jian , Hannah A D King , Cynthia G Lorang , Elizabeth J Martinez , Phyllis A Rees , Caroline E Peterson , Fabian Schmidt , Tricia J Hart , Debra K Duso , Lawrence W Kummer , Sean P Casey , Jazmean K Williams , Shruthi Kannan , Bonnie M Slike , Lauren Smith , Isabella Swafford , Paul V Thomas , Ursula Tran , Jeffrey R Currier , Diane L Bolton , Edgar Davidson , Benjamin J Doranz , Theodora Hatziioannou , Paul D Bieniasz , Dominic Paquin-Proulx , William W Reiley , Morgane Rolland , Nancy J Sullivan , Sandhya Vasan , Natalie D Collins , Kayvon Modjarrad , Gregory D Gromowski , Victoria R Polonis , Nelson L Michael , Shelly J Krebs , M Gordon Joyce

Journal: Nat Commun

PubMed ID: 38172512

Doi: 10.1038/s41467-023-44265-0.

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Therapeutic vaccination with lentiviral vector in HBV-persistent mice and two inactive HBsAg carriers

Authors: Yumeng Zhang, Maryline Bourgine , Yanmin Wan, Jieyu Song, Zongying Li, Yiqi Yu, Wangfang Jiang, Mingzhe Zhou, Cuiyuan Guo, Didier Santucci, Xiao Liang, Christian Brechot, Wenhong Zhang, Pierre Charneau, Hong Wu, Chao Qiu

Journal: Hepatology

PubMed ID: 37827470

Doi: 10.1016/j.jhep.2023.09.019

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A new antibiotic traps lipopolysaccharide in its intermembrane transporter

Authors: Karanbir S Pahil, Morgan S A Gilman, Vadim Baidin, Thomas Clairfeuille, Patrizio Mattei, Christoph Bieniossek, Fabian Dey, Dieter Muri, Remo Baettig, Michael Lobritz, Kenneth Bradley, Andrew C Kruse 4, Daniel Kahne 5

Journal: Nature

PubMed ID: 38172635

Doi: 10.1038/s41586-023-06799-7

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Computationally designed sensors detect endogenous Ras activity and signaling effectors at subcellular resolution

Authors: Jason Z. Zhang, William H. Nguyen, Nathan Greenwood, John C. Rose, Shao-En Ong, Dustin J. Maly & David Baker

Journal: Nature Biotechnol

PubMed ID: 38228150

Doi: 10.1038/s41587-023-02107-w

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Structure-guided discovery of anti-CRISPR and anti-phage defense proteins

Authors: Ning Duan , Emily Hand , Mannuku Pheko , Shikha Sharma , Akintunde Emiola

Journal: Nat Commun

PubMed ID: 38245560

Doi: 10.1038/s41467-024-45068-7

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Stabilization of the Metastable Pre-Fusion Conformation of the SARS-CoV-2 Spike Glycoprotein through N-Linked Glycosylation of the S2 Subunit

Authors: Fuwen Zan, Yao Zhou, Ting Chen , Yahan Chen, Zhixia Mu, Zhaohui Qian , Xiuyuan Ou

Journal: Viruses.

PubMed ID: 38399999

Doi: 10.3390/v16020223

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Modulations in the host cell proteome by the hantavirus nucleocapsid protein

Authors: Austin Royster, Songyang Ren, Saima Ali, Sheema Mir, Mohammad Mir

Journal: PLoS Pathog

PubMed ID: 38190410

Doi: 10.1371/journal.ppat.1011925

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A label-free high-throughput protein solubility assay and its application to Aβ40

Authors: Max Lindberg, Emil Axell, Emma Sparr, Sara Linse

Journal: Biophys Chem

PubMed ID: 38309218

Doi: 10.1016/j.bpc.2023.107165

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Identification of a novel B-cell epitope of the African swine fever virus p34 protein and development of an indirect ELISA for the detection of serum antibodies

Authors: Yuanyuan Tian, Chao Liang, Jingming Zhou, Fanglin Sun, Yankai Liu, Yumei Chen, Xifang Zhu, Hongliang Liu, Peiyang Ding, Enping Liu, Ying Zhang, Sixuan Wu, Aiping Wang

Journal: Front Microbiol

PubMed ID: 38282734

Doi: 10.3389/fmicb.2023.1308753

Variation of C-terminal domain governs RNA polymerase II genomic locations and alternative splicing in eukaryotic transcription

Authors: Qian Zhang, Wantae Kim, Svetlana Panina, Joshua E Mayfield, Bede Portz, Y Jessie Zhang

Journal: biorxiv

PubMed ID: 38260389

Doi: 10.1101/2024.01.01.573828

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