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Recombinant Bile Salt Hydrolase Enhances the Inhibition Efficiency of Taurodeoxycholic Acid against Virulence

Authors: Tahrir Alenezi, Bilal Alrubaye, Ying Fu, Janashrit Shrestha, Samar Algehani, Hong Wang, Rohana Liyanage, Xiaolun Sun

Journal: Pathogens

PubMed ID: 38921762

Doi: 10.3390/pathogens13060464

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Identification of key genes affecting ventilator-induced diaphragmatic dysfunction in diabetic mice

Authors: Rongchun Xing, Haibo Yu, Jiangtao Yu, Rong Zeng, Zhijun Xiang, Haoli Ma, Gang Li, Yan Zhao

Journal: Front Genet

PubMed ID: 38784031

Doi: 10.3389/fgene.2024.1387688

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Application of MALDI-MS for characterization of fucoidan hydrolysates and screening of endo-fucoidanase activity

Authors: Diego S Reyes-Weiss, Margot Bligh, Nanna Rhein-Knudsen, Jan-Hendrik Hehemann, Manuel Liebeke, Bjørge Westereng, Svein Jarle Horn

Journal: Carbohydr Polym

PubMed ID: 38858030

Doi: 10.1016/j.carbpol.2024.122317

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Selective activation of naïve B cells with unique epitope specificity shapes autoantibody formation in celiac disease

Authors: Saykat Das, Jorunn Stamnaes, Lene S Høydahl, Christine Skagen, Knut E A Lundin, Jørgen Jahnsen, Ludvig M Sollid, Rasmus Iversen

Journal: J Autoimmun

PubMed ID: 38754235

Doi: 10.1016/j.jaut.2024.103241

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Structural basis for raccoon dog receptor recognition by SARS-CoV-2

Authors: Fu-Chun Hsueh, Ke Shi, Alise Mendoza, Fan Bu, Wei Zhang, Hideki Aihara, Fang Li

Journal: PLoS Pathog

PubMed ID: 38709834

Doi: 10.1371/journal.ppat.1012204

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Development of multiplexed orthogonal base editor (MOBE) systems

Authors: Quinn T Cowan, Sifeng Gu, Wanjun Gu, Brodie L Ranzau, Tatum S Simonson, Alexis C Komor

Journal: Nat Biotechnol

PubMed ID: 38773305

Doi: 10.1038/s41587-024-02240-0

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The Hansenula polymorpha mitochondrial carrier family protein Mir1 is dually localized at peroxisomes and mitochondria

Authors: Marc Pilegaard Pedersen, Justina C Wolters, Rinse de Boer, Arjen M Krikken, Ida J van der Klei

Journal: Biochim Biophys Acta Mol Cell Res

PubMed ID: 38702017

Doi: 10.1016/j.bbamcr.2024.119742

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Retinal organoids with X-linked retinoschisis RS1 (E72K) mutation exhibit a photoreceptor developmental delay and are rescued by gene augmentation therapy

Authors: Chunwen Duan, Chengcheng Ding, Xihao Sun, Shengru Mao, Yuqin Liang, Xinyu Liu, Xiaoyan Ding, Jiansu Chen, Shibo Tang

Journal: Stem Cell Res Ther

PubMed ID: 38816767

Doi: 10.1186/s13287-024-03767-4

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Loss of a conserved C-terminal region of the AtrR transcriptional regulator leads to a gene-specific defect in target gene expression

Authors: Shivani Ror, Mark A Stamnes, W Scott Moye-Rowley

Journal: biorxiv

PubMed ID: 38826412

Doi: 10.1101/2024.05.22.595332

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Assessing the Impact of Novel Exon 11 Variants on Pre-mRNA Splicing

Authors: Halla Elshwekh, Inas M Alhudiri, Adam Elzagheid, Nabil Enattah, Yasmine Abbassi, Lubna Abou Assali, Ilenia Marino, Cristiana Stuani, Emanuele Buratti, Maurizio Romano

Journal: Cells

PubMed ID: 38786046

Doi: 10.3390/cells13100824

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The mitochondrial protease ClpP is a druggable target that controls VSMC phenotype by a SIRT1-dependent mechanism

Authors: Felipe Paredes, Holly C Williams, Xuesong Liu, Claire Holden, Bethany Bogan, Yu Wang, Kathryn M Crotty, Samantha M Yeligar, Alvaro A Elorza, Zhiyong Lin, Amir Rezvan, Alejandra San Martin

Journal: Redox Biol

PubMed ID: 38823208

Doi: 10.1016/j.redox.2024.103203

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Prominin 1 is crucial for the early development of photoreceptor outer segments

Authors: Sila Yanardag, Scott Rhodes, Thamaraiselvi Saravanan, Tongju Guan, Visvanathan Ramamurthy

Journal: Sci Rep

PubMed ID: 38714794

Doi: 10.1038/s41598-024-60989-5

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Virus-like particles expressing microneme-associated antigen of Plasmodium berghei confer better protection than those expressing apical membrane antigen 1

Authors: Min-Ju Kim, Ki Back Chu, Keon-Woong Yoon, Hae-Ji Kang, Dong-Hun Lee, Eun-Kyung Moon, Fu-Shi Quan

Journal: Parasites Hosts Dis

PubMed ID: 38835260

Doi: 10.3347/PHD.24017

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The three-dimensional structure of DapE from Enterococcus faecium reveals new insights into DapE/ArgE subfamily ligand specificity

Authors: Manuel Terrazas-López, Lilian González-Segura, Adelaida Díaz-Vilchis, Kelly Annecy Aguirre-Mendez, Naún Lobo-Galo, Alejandro Martínez-Martínez, Ángel G Díaz-Sánchez

Journal: Int J Biol Macromol

PubMed ID: 38740150

Doi: 10.1016/j.ijbiomac.2024.132281

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Overexpression of PEX14 results in mistargeting to mitochondria, accompanied by organelle fragmentation and clustering in human embryonic kidney cells

Authors: Renate L M Jansen, Rinse de Boer, Eline M F de Lange, Janet Koster, Rifka Vlijm, Hans R Waterham, Ida J van der Klei

Journal: Biochim Biophys Acta Mol Cell Res

PubMed ID: 38762172

Doi: 10.1016/j.bbamcr.2024.119754

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Deep mutational scanning reveals a correlation between degradation and toxicity of thousands of aspartoacylase variants

Authors: Martin Grønbæk-Thygesen, Vasileios Voutsinos, Kristoffer E. Johansson, Thea K. Schulze, Matteo Cagiada, Line Pedersen, Lene Clausen, Snehal Nariya, Rachel L. Powell, Amelie Stein, Douglas M. Fowler, Kresten Lindorff-Larsen & Rasmus Hartmann-Petersen

Journal: Nat Commun

PubMed ID: 38740822

Doi: 10.1038/s41467-024-48481-0

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Biosynthetic production of anticoagulant heparin polysaccharides through metabolic and sulfotransferases engineering strategies

Authors: Jian-Qun Deng, Yi Li, Yu-Jia Wang, Ya-Lin Cao, Si-Yu Xin, Xin-Yu Li, Rui-Min Xi, Feng-Shan Wang & Ju-Zheng Sheng

Journal: Nat Commun

PubMed ID: 38704385

Doi: 10.1038/s41467-024-48193-5

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One-pot sustainable synthesis of glucosylglycerate from starch and glycerol through artificial in vitro enzymatic cascade

Authors: Juanjuan Liu, Mengfei Ren, Haoran Ma, Huilin Zhang, Xinyu Cui, Runyuan Kang, Xinming Feng, Dongdong Meng

Journal: Bioresour Technol

PubMed ID: 38508282

Doi: 10.1016/j.biortech.2024.130611

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Wheat peptide alleviates DSS-induced colitis by activating the Keap1-Nrf2 signaling pathway and maintaining the integrity of the gut barrier

Authors: Wen-Yin Xie, Zhong-Hao Ji, Wen-Zhi Ren, Pei-Sen Zhao, Fan-Hao Wei, JinPing Hu, Bao Yuan, Wei Gao

Journal: Food Funct .

PubMed ID: 38690672

Doi: 10.1039/d3fo04413k.

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Innervation of nociceptor neurons in the spleen promotes germinal center responses and humoral immunity

Authors: Min Wu, Guangping Song, Jianing Li, Zengqing Song, Bing Zhao, Liyun Liang, Wenlong Li, Huaibin Hu, Haiqing Tu, Sen Li, Peiyao Li, Biyu Zhang , Wen Wang, Yu Zhang , Wanpeng Zhang, Weifan Zheng, Jiarong Wang, Yuqi Wen, Kai Wang, Ailing Li, Tao Zhou, Yucheng Zhang, Huiyan Li

Journal: Cell

Doi: 10.1016/j.cell.2024.04.027

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Development of advanced control material for reverse transcription-mediated bacterial nucleic acid amplification tests

Authors: Janessa D Lewis , Stephen J Salipante

Journal: J Clin Microbiol

PubMed ID: 38629844

Doi: 10.1128/jcm.00243-24

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CRISPR/Cas13a-based supersensitive circulating tumor DNA assay for detecting EGFR mutations in plasma

Authors: Li Wang , Xiaosha Wen , Yang Yang , Zheng Hu , Jing Jiang , Lili Duan , Xiaofen Liao , Yan He , Yaru Liu , Jing Wang , Zhikun Liang , Xiaoya Zhu , Quan Liu , Tiancai Liu , Dixian Luo

Journal: Commun Biol

PubMed ID: 38806596

Doi: 10.1038/s42003-024-06368-2

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The TIMELESS and PARP1 interaction suppresses replication-associated DNA gap accumulation

Authors: Joanne Saldanha , Julie Rageul , Jinal A Patel , Amy L Phi , Natalie Lo , Jennifer J Park , Hyungjin Kim

Journal: Nucleic Acids Res

PubMed ID: 38801073

Doi: 10.1093/nar/gkae445.

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Functional Application of the Single-Module NRPS-like D-Alanyltransferase in Maytansinol Biosynthesis

Authors: Zhongyue Li, Zhonghang Zhu, Guangsen Xu, Lin Wei, Jiang Liu, Haoxin Wang, Chunhua Lu, Yaoyao Li, Deyu Zhu*, and Yuemao Shen

Journal: ACS Catal

Doi: 10.1021/acscatal.4c00082

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Helicases DDX5 and DDX17 promote heterogeneity in HBV transcription termination in infected human hepatocytes

Authors: Fleur Chapus 1, Guillaume Giraud 2, Pélagie Huchon 3, Mélanie Rodà 2, Xavier Grand 2, Caroline Charre 4, Chloé Goldsmith 5, Armando Andres Roca Suarez 2, Maria-Guadalupe Martinez 1, Judith Fresquet 6, Audrey Diederichs 3, Maëlle Locatelli 1, Hélène Polvèche 7, Caroline Scholtès 8, Isabelle Chemin 2, Hector Hernandez Vargas 5, Michel Rivoire 9, Cyril F Bourgeois 10, Fabien Zoulim 11, Barbara Testoni 12

Journal: J Hepatol

PubMed ID: 38782119

Doi: doi: 10.1016/j.jhep.2024.05.016.

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Structural basis of human mpox viral DNA replication inhibition by brincidofovir and cidofovir

Authors: Yunxia Xu, Yaqi Wu, Xiaoying Wu, Yuanyuan Zhang, Yaxue Yang, Danyang Li, Biao Yang, Kaiting Gao, Zhengyu Zhang, Changjiang Dong

Journal: Int J Biol Macromol

PubMed ID: 38735603

Doi: 10.1016/j.ijbiomac.2024.132231

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but not is the avirulence determinant in melon carrying the resistance against watermelon mosaic virus, although they contain a common genetic determinant

Authors: Zhen Sun, Yu-Xuan Wu, Ling-Zhi Liu, Yan-Ping Tian, Xiang-Dong Li, Chao Geng

Journal: J Virol

PubMed ID: 38775482

Doi: 10.1128/jvi.00507-24

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Fibroblast growth factor 21 enhances learning and memory performance in mice by regulating hippocampal L-lactate homeostasis

Authors: Jiaojiao Xie, Jiapin Yan, Keru Ji, Yuejun Guo, Sibei Xu, Danjie Shen, Chen Li, Hongchang Gao, Liangcai Zhao

Journal: Int J Biol Macromol

PubMed ID: 38801850

Doi: 10.1016/j.ijbiomac.2024.132667

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Fungicidal Activity of New Pyrrolo[2,3-]thiazoles and Their Potential Action on the Tryptophan Metabolic Pathway and Wax Biosynthesis

Authors: Yue Zhang, Jing Li, Hongwei Yang, Kun Li, Haolin Yuan, Ziqiao Xue, Liangfu Tang, Zhijin Fan

Journal: J Agric Food Chem

PubMed ID: 38757490

Doi: 10.1021/acs.jafc.4c00930

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The MuSK agonist antibody protects the neuromuscular junction and extends the lifespan in C9orf72-ALS mice

Authors: Shuangshuang Sun, Yihui Shen, Xu Zhang, Ning Ding, Zhe Xu, Qijie Zhang, Lei Li

Journal: Mol Ther

PubMed ID: 38734896

Doi: 10.1016/j.ymthe.2024.05.016

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Early trajectories of virological and immunological biomarkers and clinical outcomes in patients admitted to hospital for COVID-19: an international, prospective cohort study

Authors: Tomas O Jensen, Thomas A Murray, Greg A Grandits, Mamta K Jain, Birgit Grund, Kathryn Shaw-Saliba, Michael A Matthay, Mahsa Abassi, Magdalena Ardelt, Jason V Baker, Peter Chen, Robin L Dewar, Anna L Goodman, Timothy J Hatlen, Helene C Highbarger, Mark Holodniy, Perrine Lallemand, Sylvain Laverdure, Bradley G Leshnower, David Looney, Charalampos D Moschopoulos, Henry Mugerwa, Daniel D Murray, Eleftherios Mylonakis, Stephanie Nagy-Agren, M Tauseef Rehman, Adam Rupert, Randy Stevens, Stuart Turville, Amy Weintrob, Katherine Wick, Jens Lundgren, Emily R Ko

Journal: Lancet Microbe

PubMed ID: 38815595

Doi: 10.1016/S2666-5247(24)00015-6

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Nanolevel of detection of ascorbic acid using horse-radish peroxidase inhibition assay

Authors: Bijon Kumar Sil, Mohd Raeed Jamiruddin, Md Ahsanul Haq, Nattanit Aekwattanaphol, Prem Ananth K, Limbadri Salendra, Himanshu Paliwal, Pijush Kumar Paul, Wilaiporn Buatong, Teerapol Srichana

Journal: Heliyon

PubMed ID: 38774337

Doi: 10.1016/j.heliyon.2024.e30715

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Earliest records of the Asian longhorned tick (Acari: Ixodidae) in Staten Island, New York, and subsequent population establishment, with a review of its potential medical and veterinary importance in the United States

Authors: Waheed Bajwa, Ashley Kennedy, Zachary Vincent, Garrett Heck, Shamim Riaj, Zahir Shah, Leonid Tsynman, Cory Casal, Scott Haynes, Hannah Cornman, Andrea Egizi, Ellen Stromdahl, Robyn Nadolny

Journal: J Med Entomol

PubMed ID: 38412407

Doi: 10.1093/jme/tjae019

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Characterisation of novel influenza-derived HLA-B*18:01-restricted epitopes

Authors: Samuel Liwei Leong, Lawton Murdolo, Janesha C Maddumage, Marios Koutsakos, Katherine Kedzierska, Anthony W Purcell, Stephanie Gras, Emma J Grant

Journal: Clin Transl Immunology

PubMed ID: 38737448

Doi: 10.1002/cti2.1509

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A fluorescently-tagged tick kinin neuropeptide triggers peristalsis and labels tick midgut muscles

Authors: Jonathan R Hernandez, Caixing Xiong, Patricia V Pietrantonio

Journal: Sci Rep

PubMed ID: 38740831

Doi: 10.1038/s41598-024-61570-w

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Fluorinated hydroxyapatite conditions a favorable osteo-immune microenvironment via triggering metabolic shift from glycolysis to oxidative phosphorylation

Authors: Kaidi Chen, Seongmin Ha, Leyao Xu, Chengwu Liu, Yuanxiang Liu, Xiayi Wu, Zhipeng Li, Shiyu Wu, Bo Yang, Zhuofan Chen

Journal: J Transl Med

PubMed ID: 38720345

Doi: 10.1186/s12967-024-05261-0

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Evolution of a novel adrenal cell type that promotes parental care

Authors: Natalie Niepoth, Jennifer R Merritt, Michelle Uminski, Emily Lei, Victoria S Esquibies, Ina B Bando, Kimberly Hernandez, Christoph Gebhardt, Sarah A Wacker, Stefano Lutzu, Asmita Poudel, Kiran K Soma, Stephanie Rudolph, Andres Bendesky

Journal: Nature

PubMed ID: 38750354

Doi: 10.1038/s41586-024-07423-y

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Cardiac function is regulated by the sodium-dependent inhibition of the sodium-calcium exchanger NCX1

Authors: Kyle Scranton, Scott John, Marina Angelini, Federica Steccanella, Soban Umar, Rui Zhang, Joshua I Goldhaber, Riccardo Olcese, Michela Ottolia

Journal: Nat Commun

PubMed ID: 38714663

Doi: 10.1038/s41467-024-47850-z

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Nonclinical Evaluation of Single-Mutant Asparaginases Obtained by Double-Mutant Deconvolution: Improving Toxicological, Immune and Inflammatory Responses

Authors: Grace Ruiz-Lara, Tales A Costa-Silva, Jorge Javier Muso-Cachumba, Johanna Cevallos Espinel, Marina Gabriel Fontes, Mitla Garcia-Maya, Khondaker Miraz Rahman, Carlota de Oliveira Rangel-Yagui, Gisele Monteiro

Journal: Int J Mol Sci

PubMed ID: 38892196

Doi: 10.3390/ijms25116008

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Podocyte Pathogenic Bone Morphogenetic Protein-2 Pathway and Immune Cell Behaviors in Primary Membranous Nephropathy

Authors: Anxiang Cai, Yiwei Meng, Hang Zhou, Hong Cai, Xinghua Shao, Qin Wang, Yao Xu, Yin Zhou, Wenyan Zhou, Luonan Chen, Shan Mou

Journal: Adv Sci (Weinh)

PubMed ID: 38785168

Doi: 10.1002/advs.202404151

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Context dependent activity of p63-bound gene regulatory elements

Authors: Abby A McCann, Gabriele Baniulyte, Dana L Woodstock, Morgan A Sammons

Journal: biorxiv

PubMed ID: 38766006

Doi: 10.1101/2024.05.09.593326

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Structural and functional characterization of IgG- and non-IgG-based T-cell-engaging bispecific antibodies

Authors: Nishant Mohan, Safiat Ayinde, Hanjing Peng, Shraboni Dutta, Yi Shen, Vincent M Falkowski, Thomas G Biel, Tongzhong Ju, Wen Jin Wu

Journal: Front Immunol

PubMed ID: 38863707

Doi: 10.3389/fimmu.2024.1376096

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LncRNA CCRR maintains Ca homeostasis against myocardial infarction through the FTO-SERCA2a pathway

Authors: Hua Yang, Lina Xuan, Shengjie Wang, Huishan Luo, Xiaomeng Duan, Jianjun Guo, Shijia Cui, Jieru Xin, Junwei Hao, Xiufang Li, Jun Chen, Feihan Sun, Xiaolin Hu, Siyun Li, Ying Zhang, Lei Jiao, Baofeng Yang, Lihua Sun

Journal: Sci China Life Sci

PubMed ID: 38761356

Doi: 10.1007/s11427-023-2527-5

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Conditional knockdown of OsMLH1 to improve plant prime editing systems without disturbing fertility in rice

Authors: Xiaoshuang Liu, Dongfang Gu, Yiru Zhang, Yingli Jiang, Zhi Xiao, Rongfang Xu, Ruiying Qin, Juan Li, Pengcheng Wei

Journal: Genome Biol

PubMed ID: 38773623

Doi: 10.1186/s13059-024-03282-y

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Functional characterization of a novel flavin reductase from a deep-sea sediment metagenomic library and its application for indirubin production

Authors: Jikun Du, Yuanhua Li, Zhengzhuang Chen, Chang Wang, Yali Huang, Li Li

Journal: Appl Environ Microbiol

PubMed ID: 38780258

Doi: 10.1128/aem.00429-24

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and analysis reveal impact of c-Myc tag in FMC63 scFv-CD19 protein interface and CAR-T cell efficacy

Authors: Ana Julia Ferreira Lima, Karina Lobo Hajdu, Luiza Abdo, Leonardo Ribeiro Batista-Silva, Clara de Oliveira Andrade, Eduardo Mannarino Correia, Emmanuel Arthur Albuquerque Aragão, Martín Hernán Bonamino, Marcos Roberto Lourenzoni

Journal: Comput Struct Biotechnol J

PubMed ID: 38873646

Doi: 10.1016/j.csbj.2024.05.032

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CircRNA SEC24A promotes osteoarthritis through miR-107-5p/CASP3 axis

Authors: Tuerxunjiang Dadihanc, Yong Zhang, Guo-Qing Li, Hai-Kang Zhou, Jingyong Huang, Xue Zhang, Zhi-Qiang Li, Hai-Rong Ma

Journal: Regen Ther

PubMed ID: 38828010

Doi: 10.1016/j.reth.2024.04.011

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Legionella maintains host cell ubiquitin homeostasis by effectors with unique catalytic mechanisms

Authors: Jiaqi Fu, Siying Li, Hongxin Guan, Chuang Li, Tao-Tao Chen, Wei Xian, Zhengrui Zhang, Yao Liu, Qingtian Guan, Jingting Wang, Qiuhua Lu, Lina Kang, Si-Ru Zheng, Jinyu Li, Shoujing Cao, Chittaranjan Das, Xiaoyun Liu, Lei Song, Songying Ouyang, Zhao-Qing Luo

Journal: Res Sq

PubMed ID: 38826349

Doi: 10.21203/rs.3.rs-4431542/v1

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Characterization of Esterase Capable of Hydrolyzing Bis(2-hydroxyethyl) Terephthalate

Authors: Sizhong Feng, Mengke Xue, Fang Xie, Hongyang Zhao, Yemin Xue

Journal: J Agric Food Chem

PubMed ID: 38753963

Doi: 10.1021/acs.jafc.4c01973

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Hybrid Cas12a Variants with Relaxed PAM Requirements Expand Genome Editing Compatibility

Authors: Zhenyu Liu, Huayi Liu, Chaoqun Huang, Qun Zhou, Yunzi Luo

Journal: ACS Synth Biol

PubMed ID: 38819403

Doi: 10.1021/acssynbio.4c00103

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