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Surface-engineered mesenchymal stem cell for refractory asthma therapy: Reversing airway remodeling

Authors: Xing-Yue He , Meng-Meng Han , Yu-Chen Zhao , Ling Tang , Yi Wang , Lei Xing , Ning Wei , Jing Wang , Guang-Ji Wang , Fang Zhou, Jee-Heon Jeong, Hu-Lin Jiang

Journal: Journal of controlled release

PubMed ID: 39476873

Doi: 10.1016/j.jconrel.2024.10.056

Products & Services: Recombinant Proteins

The E3 Ubiquitin Ligase FBXO38 Maintains the Antitumor Function of Natural Killer Cells by Sustaining IL15R Signaling

Authors: Yongjing Shi , Xiaodong Zheng , Hui Peng , Chenqi Xu , Rui Sun , Zhigang Tian , Haoyu Sun , Xianwei Wang

Journal: Cancer Immunol Res

PubMed ID: 38990095

Doi: 10.1158/2326-6066.CIR-23-1061

Products & Services: Protein and Antibody Isolation

Neddylation and Its Target Cullin 3 Are Essential for Adipocyte Differentiation

Authors: Hongyi Zhou , Vijay Patel , Robert Rice , Richard Lee , Ha Won Kim , Neal L Weintraub , Huabo Su , Weiqin Chen

Journal: Cells

PubMed ID: 39404417

Doi: 10.3390/cells13191654

Products & Services: CRISPR Libraries

Activation of polycystin-1 signaling by binding of stalk-derived peptide agonists

Authors: Shristi Pawnikar; Brenda S Magenheimer; Keya Joshi; Ericka Nevarez-Munoz; Allan Haldane; Robin L Maser; Yinglong Miao; Qiang Cui; Shristi Pawnikar; Brenda Magenheimer; Keya Joshi; Ericka Nevarez-Munoz; Allan Haldane; Robin Maser; Yinglong Miao

Journal: Elife

PubMed ID: 39373641

Doi: 10.7554/eLife.95992

Products & Services: Peptide Synthesis

Target-based design of praziquantel analogs at cestode TRPM PZQ

Authors: Daniel J. Sprague; Sang-Kyu Park; Marc Kaethner; Claudia M. Rohr; Mina R. Ghobrial; D. Connor Barth; David Maillard; Thomas Spangenberg; Britta Lundstr m-Stadelmann; Jonathan S. Marchant

Journal: ACS Infectious Diseases

PubMed ID: 40754814

Doi: 10.1021/acsinfecdis.5c00449

Target-based design of praziquantel analogs at cestode TRPM PZQ

Authors: Daniel J. Sprague; Sang-Kyu Park; Marc Kaethner; Claudia M. Rohr; Mina R. Ghobrial; D. Connor Barth; David Maillard; Thomas Spangenberg; Britta Lundstr m-Stadelmann; Jonathan S. Marchant

Journal: ACS Infectious Diseases

PubMed ID: 40754814

Doi: 10.1021/acsinfecdis.5c00449

Target-based design of praziquantel analogs at cestode TRPM PZQ

Authors: Daniel J. Sprague; Sang-Kyu Park; Marc Kaethner; Claudia M. Rohr; Mina R. Ghobrial; D. Connor Barth; David Maillard; Thomas Spangenberg; Britta Lundstr m-Stadelmann; Jonathan S. Marchant

Journal: ACS Infectious Diseases

PubMed ID: 40754814

Doi: 10.1021/acsinfecdis.5c00449

Structure of Plasmodium vivax N -myristoyltransferase with inhibitor IMP-1088: exploring an NMT inhibitor for antimalarial therapy

Authors: Alex Mendez; Cydni Bolling; Shane Taylor; Stanley Makumire; Bart Staker; Alexandra Reers; Brad Hammerson; Stephen J. Mayclin; Jan Abendroth; Donald D. Lorimer; Thomas E. Edwards; Edward W. Tate; Sandhya Subramanian; Andrew S. Bell; Peter J. Myler; Oluwatoyin A. Asojo; Graham Chakafana

Journal: Acta Crystallographica Section F: Structural Biology Communications

PubMed ID: 39655507

Doi: 10.1107/S2053230X24011348

Two riboswitch classes that share a common ligand-binding fold show major differences in the ability to accommodate mutations

Authors: Yoshita Srivastava , Olayinka Akinyemi , Tiana C Rohe , Elizabeth M Pritchett , Cameron D Baker , Akshara Sharma , Jermaine L Jenkins , David H Mathews , Joseph E Wedekind

Journal: Nucleic Acids Research

PubMed ID: 39413212

Doi: 10.1093/nar/gkae886

Products & Services: CRISPR KI Templates PCR Cloning and Subcloning Mutagenesis Services

Disrupting Intracellular Homeostasis by Copper-Based Nanoinducer with Multiple Enzyme-Mimicking Activities to Induce Disulfidptosis-Enhanced Pyroptosis for Tumor Immunotherapy

Authors: Xiao-Kang Jin , Shun-Kang Zhang , Shi-Man Zhang , Jun-Long Liang , Xiao Yan , Yan-Tong Lin , Ran Meng , Zi-Han Xu , Chuan-Jun Liu , Xian-Zheng Zhang

Journal: ADVANCED MATERIALS

PubMed ID: 39468892

Doi: 10.1002/adma.202410957

Products & Services: Recombinant Proteins

The TMEM63B Channel Facilitates Intestinal Motility and Enhances Proliferation of Intestinal Stem Cells

Authors: Jing-Jing Tu , Yan-Yu Zang , Yun Stone Shi ,and Xiao-Yu Teng

Journal: Cells

Doi: doi.org/10.3390/cells13211784

Products & Services: Molecular Biology Reagents

5′-tRNAGly(GCC) halves generated by IRE1α are linked to the ER stress response

Authors: Hanyong Jin , Ji-Hyun Yeom , Eunkyoung Shin , Yoonjie Ha , Haifeng Liu , Daeyoung Kim , Minju Joo , Yong-Hak Kim , Hak Kyun Kim , Minkyung Ryu, Hong-Man Kim , Jeongkyu Kim , Keun P Kim , Yoonsoo Hahn , Jeehyeon Bae , Kangseok Lee

Journal: Nature Communications

PubMed ID: 39468069

Doi: 10.1038/s41467-024-53624-4

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Zinc oxide nanoparticles with catalase-like nanozyme activity and near-infrared light response: A combination of effective photodynamic therapy, autophagy, ferroptosis, and antitumor immunity

Authors: Jingru Wang , Man Liu , Jingwen Wang , Zhuoyue Li , Zhenhan Feng , Meiqi Xu , Hui Wang , Hui Li , Zhantao Li , Jianming Yu , Junwei Liu , Qingchao Wei , Shuang Zhang , Xuan Zhang

Journal: Acta Pharm Sin B

PubMed ID: 39525585

Doi: 10.1016/j.apsb.2024.07.002

Products & Services: Recombinant Proteins

Acute GARP Depletion Disrupts Vesicle Transport, Leading to Severe Defects in Sorting, Secretion and O-Glycosylation

Authors: Amrita Khakurel , Irina Pokrovskaya , Vladimir V Lupashin

Journal: Traffic

PubMed ID: 39416116

Doi: 10.1111/tra.70003

Products & Services: Protein and Antibody Isolation Gene Synthesis

Molecular Modeling and In Vitro Functional Analysis of the RGS12 PDZ Domain Variant Associated with High-Penetrance Familial Bipolar Disorder

Authors: Percy S Agogo-Mawuli, Joseph Mendez, Emily A Oestreich, Dustin E Bosch, David P Siderovski

Journal: International Journal of Molecular Sciences

PubMed ID: 39518985

Doi: 10.3390/ijms252111431

Products & Services: Peptide Synthesis Bacterial Expression

Target-based design of praziquantel analogs at cestode TRPM PZQ

Authors: Daniel J. Sprague; Sang-Kyu Park; Marc Kaethner; Claudia M. Rohr; Mina R. Ghobrial; D. Connor Barth; David Maillard; Thomas Spangenberg; Britta Lundstr m-Stadelmann; Jonathan S. Marchant

Journal: ACS Infectious Diseases

PubMed ID: 40754814

Doi: 10.1021/acsinfecdis.5c00449

Enhanced HIV SOSIP Envelope yields in plants through transient co-expression of peptidyl-prolyl isomerase B and calreticulin chaperones and ER targeting

Authors: Yvonne J. Rosenberg; Xiaoming Jiang; Jonathan P. Lees; Lori A. Urban; Lingjun Mao; Markus Sack

Journal: Scientific REPORTS

PubMed ID: 35705669

Doi: 10.1038/s41598-022-14075-3

Products & Services: Catalog Antibodies

Structure of Plasmodium vivax N -myristoyltransferase with inhibitor IMP-1088: exploring an NMT inhibitor for antimalarial therapy

Journal: Acta Crystallographica Section F: Structural Biology Communications

PubMed ID: 39655507

Doi: 10.1107/S2053230X24011348

A novel strategy of co-expressing CXCR5 and IL-7 enhances CAR-T cell effectiveness in osteosarcoma

Authors: Xinhui Hui1†Muhammad Asad Farooq,&#x;Muhammad Asad Farooq1,2†Yiran ChenYiran Chen1Iqra Ajmal,Iqra Ajmal1,2Yaojun Ren,Yaojun Ren1,3Min XueMin Xue1Yuzhou JiYuzhou Ji1Bingtan DuBingtan Du1Shijia WuShijia Wu1Wenzheng Jiang*&#x;Wenzheng Jiang1*‡

Journal: Frontiers in Immunology

Doi: doi.org/10.3389/fimmu.2024.1462076

Products & Services: Nucleic Acid Purification

AtPRMT3-RPS2B promotes ribosome biogenesis and coordinates growth and cold adaptation trade-off

Authors: Zhen Wang , Xiaofan Zhang , Chunyan Liu , Susan Duncan , Runlai Hang , Jing Sun , Lilan Luo , Yiliang Ding , Xiaofeng Cao

Journal: Nature Communications

PubMed ID: 39375381

Doi: 10.1038/s41467-024-52945-8

Products & Services: Protein and Antibody Isolation

Controlled TPCA-1 delivery engineers a pro-tenogenic niche to initiate tendon regeneration by targeting IKKβ/NF-κB signaling

Authors: Jialin Chen , Renwang Sheng , Qingyun Mo , Ludvig J Backman , Zhiyuan Lu , Qiuzi Long , Zhixuan Chen , Zhicheng Cao , Yanan Zhang , Chuanquan Liu , Haotian Zheng , Yu Qi , Mumin Cao , Yunfeng Rui , Wei Zhang

Journal: Bioact Mater

PubMed ID: 39512422

Doi: 10.1016/j.bioactmat.2024.10.016

Products & Services: Recombinant Proteins

Bitter taste receptor TAS2R14 activation and G protein assembly by an intracellular agonist

Authors: Lele Tao , Dongxue Wang , Qingning Yuan Fenghui Zhao , Yu Zhang , Tianyuan Du , Shiyi Shen , H Eric Xu , Yi Li , Dehua Yang , Jia Duan

Journal: Cell Research

PubMed ID: 38969802

Doi: 10.1038/s41422-024-00995-4

Products & Services: Catalog Peptides

Retrograde transport of neurotrophin receptor TrkB-FL induced by excitotoxicity regulates Golgi stability and is a target for stroke neuroprotection

Authors: Gema María Esteban-Ortega, Margarita Díaz-Guerra

Journal: biorxiv

Doi: doi.org/10.1101/2024.10.29.620835

Products & Services: Peptide Synthesis Protein and Antibody Isolation

ERK1/2 interaction with DHPS regulates eIF5A deoxyhypusination independently of ERK kinase activity

Authors: Andrew E Becker, Paweł Kochanowski, Pui-Kei Wu, Elżbieta Wątor, Wenjing Chen, Koushik Guchhait, Artur P Biela, Przemysław Grudnik, Jong-In Park

Journal: Cell Reports

PubMed ID: 39392755

Doi: 10.1016/j.celrep.2024.114831

Products & Services: Gene Synthesis

ER-mitochondria distance is a critical parameter for efficient mitochondrial Ca2+ uptake and oxidative metabolism

Authors: Giulia Dematteis, Laura Tapella, Claudio Casali, Maria Talmon, Elisa Tonelli, Simone Reano, Adele Ariotti, Emanuela Pessolano, Justyna Malecka, Gabriela Chrostek, Gabrielė Kulkovienė, Danielius Umbrasas, Carla Distasi, Mariagrazia Grilli, Graham Ladds, Nicoletta Filigheddu, Luigia Grazia Fresu, Katsuhiko Mikoshiba, Carlos Matute, Paula Ramos-Gonzalez, Aiste Jekabsone, Tito Calì, Marisa Brini, Marco Biggiogera, Fabio Cavaliere, Riccardo Miggiano, Armando A Genazzani, Dmitry Lim

Journal: Communications Biology

PubMed ID: 39390051

Doi: 10.1038/s42003-024-06933-9

Products & Services: Gene Synthesis

Delayed reinforcement of costimulation improves the efficacy of mRNA vaccines in mice

Authors: Sarah Sanchez, Tanushree Dangi, Bakare Awakoaiye, Min Han Lew, Nahid Irani, Slim Fourati, Pablo Penaloza-MacMaster

Journal: The Journal of clinical investigation

PubMed ID: 39432667

Doi: 10.1172/jci183973

Products & Services: Custom mRNA synthesis

Next-generation cell-penetrating antibodies for tumor targeting and RAD51 inhibition

Authors: Madison Rackear, Elias Quijano, Zaira Ianniello, Daniel A Colón-Ríos, Adam Krysztofiak, Rashed Abdullah, Yanfeng Liu, Faye A Rogers, Dale L Ludwig, Rohini Dwivedi, Franziska Bleichert, Peter M Glazer

Journal: Oncotarget

PubMed ID: 39352803

Doi: 10.18632/oncotarget.28651

Products & Services: Mammalian Expression Custom mRNA synthesis

Activation of polycystin-1 signaling by binding of stalk-derived peptide agonists

Journal: Elife

PubMed ID: 39373641

Doi: 10.7554/eLife.95992

Products & Services: Peptide Synthesis

Enhanced HIV SOSIP Envelope yields in plants through transient co-expression of peptidyl-prolyl isomerase B and calreticulin chaperones and ER targeting

Authors: Yvonne J. Rosenberg; Xiaoming Jiang; Jonathan P. Lees; Lori A. Urban; Lingjun Mao; Markus Sack

Journal: Scientific REPORTS

PubMed ID: 35705669

Doi: 10.1038/s41598-022-14075-3

Products & Services: Catalog Antibodies

Mechanism of nucleosomal H2A K13/15 monoubiquitination and adjacent dual monoubiquitination by RNF168

Authors: Huasong Ai , Zebin Tong , Zhiheng Deng , Qiang Shi, Shixian Tao , Gaoge Sun, Jiawei Liang , Maoshen Sun , Xiangwei Wu , Qingyun Zheng , Lujun Liang , Hang Yin , Jia-Bin Li , Shuai Gao , Changlin Tian , Lei Liu , Man Pan

Journal: Nature Chemical Biology

PubMed ID: 39394267

Doi: doi.org/10.1038/s41589-024-01750-x

Products & Services: Gene Synthesis Molecular Biology Reagents

Natural SNP Variation in GbOSM1 Promotor Enhances Verticillium Wilt Resistance in Cotton

Authors: Guilin Wang, Dayong Zhang , Haitang Wang , Jinmin Kong , Zhiguo Chen , Chaofeng Ruan , Chaoyang Deng , Qihang Zheng , Zhan Guo , Hanqiao Liu, Weixi Li , Xinyu Wang , Wangzhen Guo

Journal: Advanced Science

PubMed ID: 39413014

Doi: 10.1002/advs.202406522

Products & Services: Protein and Antibody Isolation

4-aminopyridine attenuates inflammation and apoptosis and increases angiogenesis to promote skin regeneration following a burn injury in mice

Authors: Rahul V G , Govindaraj Ellur , Amir A Gaber , Prem Kumar Govindappa , John C Elfar

Journal: Cell Death Discov

PubMed ID: 39366954

Doi: 10.1038/s41420-024-02199-6

Products & Services: Protein and Antibody Isolation

Vaccination generates functional progenitor tumor-specific CD8 T cells and long-term tumor control

Authors: Carlos R Detrés Román, Megan M Erwin, Michael W Rudloff, Frank Revetta, Kristen A Murray, Natalie R Favret, Jessica J Roetman, Joseph T Roland, Mary K Washington, Mary Philip

Journal: J Immunother Cancer

PubMed ID: 39362791

Doi: 10.1136/jitc-2024-009129

Products & Services: Peptide Synthesis

Broad cross neutralizing antibodies against sarbecoviruses generated by SARS-CoV-2 infection and vaccination in humans

Authors: Yabin Hu, Qian Wu, Fangfang Chang, Jing Yang, Xiaoyue Zhang, Qijie Wang, Jun Chen, Shishan Teng, Yongchen Liu, Xingyu Zheng, You Wang, Rui Lu, Dong Pan, Zhanpeng Liu, Fen Liu, Tianyi Xie, Chanfeng Wu, Yinggen Tang, Fei Tang, Jun Qian, Hongying Chen, Wenpei Liu, Yi-Ping Li, Xiaowang Qu

Journal: npj Vaccines

PubMed ID: 39438493

Doi: 10.1038/s41541-024-00997-8

Products & Services: Gene Synthesis

Gegen Qinlian Decoction reverses oxaliplatin resistance in colorectal cancer by inhibiting YTHDF1-regulated m6A modification of GLS1

Authors: Xiang Lin , Li Xu , Meng Gu , Huan Shao , Li Yao , Xuan Huang

Journal: Phytomedicine

PubMed ID: 39089089

Doi: 10.1016/j.phymed.2024.155906

Products & Services: Protein Electrophoresis and Western

Structure of Plasmodium vivax N -myristoyltransferase with inhibitor IMP-1088: exploring an NMT inhibitor for antimalarial therapy

Journal: Acta Crystallographica Section F: Structural Biology Communications

PubMed ID: 39655507

Doi: 10.1107/S2053230X24011348

Efficient Design of Affilin Protein Binders for HER3

Authors: Anna M. Diaz-Rovira; Jonathan Lotze; Gregor Hoffmann; Chiara Pallara; Alexis Molina; Ina Coburger; Manja Gloser-Br unig; Maren Meysing; Madlen Zwarg; Luc a D az; Victor Guallar; Eva Bosse-Doenecke; Sergi Roda

Journal: International Journal of Molecular Sciences

PubMed ID: 40429825

Doi: 10.3390/ijms26104683

Products & Services: Catalog Antibodies

Far-red light photoacclimation in a desert Chroococcidiopsis strain with a reduced FaRLiP gene cluster and expression of its chlorophyll f synthase in space-resistant isolates

Authors: Giorgia di Stefano, Mariano Battistuzzi, Nicoletta La Rocca, Vera M Selinger, Dennis J Nürnberg, Daniela Billi

Journal: Frontiers in Microbiology

PubMed ID: 39328908

Doi: 10.3389/fmicb.2024.1450575

Products & Services: Gene Synthesis

Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket

Authors: Johannes Morstein , Victoria Bowcut , Micah Fernando , Yue Yang , Lawrence Zhu , Meredith L Jenkins , John T Evans , Keelan Z Guiley , D Matthew Peacock , Sophie Krahnke , Zhi Lin , Katrine A Taran , Benjamin J Huang , Andrew G Stephen , John E Burke , Felice C Lightstone , Kevan M Shokat

Journal: Cell

PubMed ID: 39255801

Doi: 10.1016/j.cell.2024.08.017

Products & Services: DNA Sequencing

Accelerated discovery and miniaturization of novel single-stranded cytidine deaminases

Authors: Jiacheng Deng,† , Xueyuan Li,† , Hao Yu,† , Lin Yang1, Ziru Wang1, Wenfeng Yi, Ying Liu, Wenyu Xiao, Hongyong Xiang, Zicong Xie, Dongmei Lv, Hongsheng Ouyang, Daxin Pang, * and Hongming Yuan

Journal: Nucleic Acids Research

PubMed ID: 39271120

Doi: doi.org/10.1093/nar/gkae800

Products & Services: Gene Synthesis

Rational design of a DNA-launched live attenuated vaccine against human enterovirus 71

Authors: Rong-Rong Zhang 1, Meng-Jiao He 1, Chao Zhou 1, Yan-Peng Xu 1, Wei Tang 1, Tian-Shu Cao 1, Zheng-Jian Wang , Mei Wu , Tao Ming , Yi-Jiao Huang , Meng-Xu Sun , Hui Zhao , Yong-Qiang Deng , Xiao-Feng Li , Bin Wang , Qing Ye , Cheng-Feng Qin

Journal: VIROLOGICA SINICA

PubMed ID: 39306193

Doi: 10.1016/j.virs.2024.09.008

Products & Services: Peptide Tools

Crystal structure and nucleic acid binding mode of CPV NSP9: implications for viroplasm in Reovirales

Authors: Yeda Wang , Hangtian Guo , Yuhao Lu , Wanbin Yang , Tinghan Li , Xiaoyun Ji

Journal: Nucleic Acids Research

PubMed ID: 39287123

Doi: doi.org/10.1093/nar/gkae803

Products & Services: Gene Synthesis

Efficient circularization of protein-encoding RNAs via a novel cis-splicing system

Authors: Shaojun Qi , Huiming Wang , Guopeng Liu , Qianshan Qin , Peng Gao , Bo Ying

Journal: Nucleic Acids Research

PubMed ID: 39162233

Doi: 10.1093/nar/gkae711

Products & Services: Gene Synthesis

Intein splicing efficiency and RadA levels can control the mode of archaeal DNA replication

Authors: Geraldy L S Liman , Christopher W Lennon , Jaylin L Mandley , Alina M Galyon , Kelly M Zatopek , Andrew F Gardner , Thomas J Santangelo

Journal: SCIENCE ADVANCES

PubMed ID: 39292776

Doi: 10.1126/sciadv.adp4995

Products & Services: Gene Synthesis Mutagenesis Services

Orientia tsutsugamushi Ank5 promotes NLRC5 cytoplasmic retention and degradation to inhibit MHC class I expression

Authors: Haley E Adcox , Jason R Hunt , Paige E Allen , Thomas E Siff , Kyle G Rodino , Andrew K Ottens , Jason A Carlyon

Journal: Nature Communications

PubMed ID: 39277599

Doi: 10.1038/s41467-024-52119-6

Products & Services: Custom Vector Construction Codon Optimization

Lysophospholipid signaling coordinates outer membrane homeostasis in Escherichia coli

Authors: Gerald R. Enverso; M. Stephen Trent

Journal: MBio

PubMed ID: 41979331

Doi: 10.1128/mbio.00567-26

Products & Services: Gene Synthesis

Pleiotropic Anti-Cancer Activities of Novel Non-Covalent Thioredoxin Reductase Inhibitors Against Triple Negative Breast Cancer

Authors: Brenna Flowers; Abigail Rullo; An Zhang; Keacha Chang; Valentina Z. Petukhova; Sammy Y. Aboagye; Francesco Angelucci; David L. Williams; Steven Kregel; Pavel Petukhov; Irida Kastrati

Journal: Free radical biology & medicine

PubMed ID: 39643141

Doi: 10.1016/j.freeradbiomed.2024.12.010

Pleiotropic Anti-Cancer Activities of Novel Non-Covalent Thioredoxin Reductase Inhibitors Against Triple Negative Breast Cancer

Authors: Brenna Flowers; Abigail Rullo; An Zhang; Keacha Chang; Valentina Z. Petukhova; Sammy Y. Aboagye; Francesco Angelucci; David L. Williams; Steven Kregel; Pavel Petukhov; Irida Kastrati

Journal: Free radical biology & medicine

PubMed ID: 39643141

Doi: 10.1016/j.freeradbiomed.2024.12.010

Design of a Fluorescence Polarization Probe for Enterovirus 2C Proteins

Authors: Kan Li; Hiwot A Demssie; Jun Wang

Journal: Journal of Medicinal Chemistry

PubMed ID: 40542722

Doi: 10.1021/acs.jmedchem.5c01219

Design of a Fluorescence Polarization Probe for Enterovirus 2C Proteins

Authors: Kan Li; Hiwot A Demssie; Jun Wang

Journal: Journal of Medicinal Chemistry

PubMed ID: 40542722

Doi: 10.1021/acs.jmedchem.5c01219