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CDKN2A/B homozygous deletion sensitizes IDH-mutant glioma to CDK4/6 inhibition

Authors: Ali M Nasser, Lisa Melamed, Ethan Wetzel, Chia-Chen Chang, Hiroaki Nagashima, Yosuke Kitagawa, Logan Muzyka, Hiroaki Wakimoto, Daniel P Cahill, Julie J Miller

Journal: Clin Cancer Res

PubMed ID: 38718141

Doi: 10.1158/1078-0432.CCR-24-0562

Products & Services: Protein and Antibody Isolation

Glycosyl transferase GT2 genes mediate the biosynthesis of an unusual (1,3;1,4)-β-glucan exopolysaccharide in the bacterium Sarcina ventriculi

Authors: Edwin R Lampugnani, Kris Ford, Yin Ying Ho, Allison van de Meene, Jelle Lahnstein, Hwei-Ting Tan, Rachel A Burton, Geoffrey B Fincher, Thomas Shafee, Antony Bacic, Jochen Zimmer, Xiaohui Xing, Vincent Bulone, Monika S Doblin, Eric M Roberts

Journal: Mol Microbiol

PubMed ID: 38750617

Doi: 10.1111/mmi.15276

Products & Services: DNA Sequencing

Targeting Prohibitin 2-Hu-Hsp70A1A complex as a unique approach towards malaria vaccine development

Authors: Manisha Marothia, Ankita Behl, Preeti Maurya, Monika Saini, Rumaisha Shoaib, Swati Garg, Geeta Kumari, Shreeja Biswas, Akshay Munjal, Sakshi Anand, Amandeep Kaur Kahlon, Pragya Gupta, Saurav Biswas, Bidhan Goswami, Haider Thaer Abdulhameed Almuqdadi, Ipsita Pal Bhowmick, Maxim Shevtsov, Sivaprakash Ramalingam, Anand Ranganathan, Shailja Singh

Journal: iScience

PubMed ID: 38812541

Doi: 10.1016/j.isci.2024.109918

Products & Services: Codon Optimization

Vitamin E alleviates chlorpyrifos induced glutathione depletion, lipid peroxidation and iron accumulation to inhibit ferroptosis in hepatocytes and mitigate toxicity in zebrafish

Authors: Poulami Sen Gupta, Subrata Karmakar, Ipsita Biswas, Jahnabi Ghosal, Ankur Banerjee, Soumen Roy, Deba Prasad Mandal, Shamee Bhattacharjee

Journal: Chemosphere

PubMed ID: 38735493

Doi: 10.1016/j.chemosphere.2024.142252

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Engineering non-conventional yeast Rhodotorula toruloides for ergothioneine production

Authors: Ke Liu, Gedan Xiang, Lekai Li, Tao Liu, Jie Ke, Liangbin Xiong, Dongzhi Wei, Fengqing Wang

Journal: Biotechnol Biofuels Bioprod

PubMed ID: 38741169

Doi: 10.1186/s13068-024-02516-2

Products & Services: Molecular Biology Reagents

Optimizing interleukin-6 and 8 expression, clarification and purification in plant cell packs and plants for application in advanced therapy medicinal products and cellular agriculture

Authors: P Opdensteinen, J F Buyel

Journal: J Biotechnol

PubMed ID: 38740307

Doi: 10.1016/j.jbiotec.2024.05.003

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Evolved histone tail regulates 53BP1 recruitment at damaged chromatin

Authors: Jessica L Kelliher, Melissa L Folkerts, Kaiyuan V Shen, Wan Song, Kyle Tengler, Clara M Stiefel, Seong-Ok Lee, Eloise Dray, Weixing Zhao, Brian Koss, Nicholas R Pannunzio, Justin W Leung

Journal: Nat Commun

PubMed ID: 38821984

Doi: 10.1038/s41467-024-49071-w

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HAP40 modulates mutant Huntingtin aggregation and toxicity in Huntington's disease mice

Authors: Laiqiang Chen, Yiyang Qin, Tingting Guo, Wenzhen Zhu, Jingpan Lin, Tingting Xing, Xuezhi Duan, Yiran Zhang, Eshu Ruan, Xiang Li, Peng Yin, Shihua Li, Xiao-Jiang Li, Su Yang

Journal: Cell Death Dis

PubMed ID: 38744826

Doi: 10.1038/s41419-024-06716-4

Products & Services: Protein Electrophoresis and Western

Type IX Collagen Turnover Is Altered in Patients with Solid Tumors

Authors: Helena Port, Yi He, Morten A Karsdal, Emilie A Madsen, Anne-Christine Bay-Jensen, Nicholas Willumsen, Signe Holm Nielsen

Journal: Cancers (Basel)

PubMed ID: 38893155

Doi: 10.3390/cancers16112035

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AAV-mediated Gene Cocktails Enhance Supporting Cell Reprogramming and Hair Cell Regeneration

Authors: Liyan Zhang, Xin Chen, Xinlin Wang, Yinyi Zhou, Yuan Fang, Xingliang Gu, Ziyu Zhang, Qiuhan Sun, Nianci Li, Lei Xu, Fangzhi Tan, Renjie Chai, Jieyu Qi

Journal: Adv Sci (Weinh)

PubMed ID: 38810137

Doi: 10.1002/advs.202304551

Products & Services: Protein and Antibody Isolation

Development of a Fully Protective Pandemic Avian Influenza Subunit Vaccine in Insect Pupae

Authors: Ana Falcón, Susana Martínez-Pulgarín, Sergi López-Serrano, Edel Reytor, Miguel Cid, Maria Del Carmen Nuñez, Lorena Córdoba, Ayub Darji, José M Escribano

Journal: Viruses

PubMed ID: 38932122

Doi: 10.3390/v16060829

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Paraquat disrupts KIF5A-mediated axonal mitochondrial transport in midbrain neurons and its antagonism by melatonin

Authors: Huihui Hong, Jingdian Li, Tong Tong, Ting Yang, Hui Wang, Yudong Xu, Xiqin Lin, Jinxian Lin, Sicheng Liu, Kun Luo, Zhengping Yu, Wei Yuan, Huifeng Pi, Zhou Zhou

Journal: Sci Total Environ

PubMed ID: 38750743

Doi: 10.1016/j.scitotenv.2024.173119

Products & Services: Molecular Biology Reagents

Whole-cell one-pot biosynthesis of dodecanedioic acid from renewable linoleic acid

Authors: Yi-Ke Qi, Jiang Pan, Zhi-Jun Zhang, Jian-He Xu

Journal: Bioresour Bioprocess

PubMed ID: 38780695

Doi: 10.1186/s40643-024-00770-8

Products & Services: Gene Synthesis

Universal paramyxovirus vaccine design by stabilizing regions involved in structural transformation of the fusion protein

Authors: Johannes P M Langedijk, Freek Cox, Nicole V Johnson, Daan van Overveld, Lam Le, Ward van den Hoogen, Richard Voorzaat, Roland Zahn, Leslie van der Fits, Jarek Juraszek, Jason S McLellan, Mark J G Bakkers

Journal: Nat Commun

PubMed ID: 38821950

Doi: 10.1038/s41467-024-48059-w

Products & Services: Molecular Biology Reagents

Dynamics of the Herpes simplex virus DNA polymerase holoenzyme during DNA synthesis and proof-reading revealed by Cryo-EM

Authors: Emil Gustavsson, Kay Grünewald, Per Elias, B Martin Hällberg

Journal: Nucleic Acids Res

PubMed ID: 38806233

Doi: 10.1093/nar/gkae374

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A recombinant plasmid encoding human hepatocyte growth factor promotes healing of combined radiation-trauma skin injury involved in regulating Nrf2 pathway in mice

Authors: Dujuan Li, Yuxin Lu, Fengjun Xiao, Xiaochen Cheng, Chunsheng Hu, Xuefeng Zhu, Xiaoying Wang, Haiying Duan, Li Du, Qinglin Zhang

Journal: J Radiat Res

PubMed ID: 38682896

Doi: 10.1093/jrr/rrae011

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Targeted complement inhibition using bispecific antibodies that bind local antigens and endogenous complement regulators

Authors: Haiyu Wang, Fleur S van de Bovenkamp, Douwe J Dijkstra, Leoni Abendstein, Nicole V Borggreven, Jos Pool, Rob Zuijderduijn, Christoph Gstöttner, Kyra A Gelderman, Timon Damelang, Gestur Vidarsson, Anna M Blom, Elena Domínguez-Vega, Paul W H I Parren, Thomas H Sharp, Leendert A Trouw

Journal: Front Immunol

PubMed ID: 38817607

Doi: 10.3389/fimmu.2024.1288597

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Improvement of tumor neoantigen detection by high field asymmetric waveform ion mobility mass spectrometry

Authors: Wei Meng, Yoshiko Takeuchi, Jeffrey P Ward, Hussein Sultan, Cora D Arthur, Elaine R Mardis, Maxim N Artyomov, Cheryl F Lichti, Robert D Schreiber

Journal: Cancer Immunol Res

PubMed ID: 38768391

Doi: 10.1158/2326-6066.CIR-23-0900

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Curing of a field strain of Salmonella enterica serovar Infantis isolated from poultry from its highly stable pESI like plasmid

Authors: Nadya Gruzdev, Chen Katz, Itamar Yadid

Journal: J Microbiol Methods

PubMed ID: 38782300

Doi: 10.1016/j.mimet.2024.106959

Products & Services: Codon Optimization

Long-term stability and immunogenicity of lipid nanoparticle COVID-19 mRNA vaccine is affected by particle size

Authors: Ruimeng Shi, Xueli Liu, Yajuan Wang, Meilu Pan, Shaoqin Wang, Lin Shi, Beibei Ni

Journal: Hum Vaccin Immunother

PubMed ID: 38714327

Doi: 10.1080/21645515.2024.2342592

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A rapid and sensitive aptamer-based biosensor for beta-lactoglobulin in milk

Authors: Anqi Liu, Meng Jiang, Yuyin Wu, Han Guo, Ling Kong, Zhiwei Chen, Zhaofeng Luo

Journal: Anal Methods

PubMed ID: 38682261

Doi: 10.1039/d4ay00460d

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Transgene removal using an in cis programmed homing endonuclease via single-strand annealing in the mosquito Aedes aegypti

Authors: Keun Chae, Bryan Contreras, Joseph S Romanowski, Chanell Dawson, Kevin M Myles, Zach N Adelman

Journal: Commun Biol

PubMed ID: 38811748

Doi: 10.1038/s42003-024-06348-6

Products & Services: Gene Synthesis

A recombinant chimeric antigen constructed with B-cell epitopes from Mycobacterium leprae hypothetical proteins is effective for the diagnosis of leprosy

Authors: Bárbara P N Assis, Ana T Chaves, Daniela P Lage, Mariana M Cardoso, Isabela A G Pereira, Raquel S B Câmara, Camila S Freitas, Vívian T Martins, Fernanda Ludolf, Ana Laura G de Oliveira, João A Oliveira-da-Silva, Grasiele S V Tavares, Alexsandro S Galdino, Miguel A Chávez-Fumagalli, Ricardo A Machado-de-Ávila, Myron Christodoulides, Denise U Gonçalves, Lílian L Bueno, Ricardo T Fujiwara, Eduardo A F Coelho, Manoel Otávio da Costa Rocha

Journal: Diagn Microbiol Infect Dis

PubMed ID: 38718661

Doi: 10.1016/j.diagmicrobio.2024.116338

Products & Services: Recombinant Proteins

Kaposi sarcoma-associated herpesvirus complement control protein (KCP) and glycoprotein K81 are not required for viral infection or

Authors: Murali Muniraju, Lorraine Z Mutsvunguma, Ivana G Reidel, Gabriela M Escalante, Simeon Cua, Webster Musonda, Jonathan Calero-Landa, Mafalda A Farelo, Esther Rodriguez, Zhou Li, Javier Gordon Ogembo

Journal: J Virol

PubMed ID: 38767375

Doi: 10.1128/jvi.00576-24

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Engineered coiled-coil HIF1α protein domain mimic

Authors: Dustin Britton, Olga Katsara, Orin Mishkit, Andrew Wang, Neelam Pandya, Chengliang Liu, Heather Mao, Jakub Legocki, Sihan Jia, Yingxin Xiao, Orlando Aristizabal, Deven Paul, Yan Deng, Robert Schneider, Youssef Z Wadghiri, Jin Kim Montclare

Journal: Biomater Sci

PubMed ID: 38656316

Doi: 10.1039/d4bm00354c

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Rational design and production of a chimeric antigen targeting Zika virus that induces neutralizing antibodies in mice

Authors: Arleth Miranda-López, Omar González-Ortega, Dania O Govea-Alonso, Lourdes Betancourt-Mendiola, Mauricio Comas-García, Sergio Rosales-Mendoza

Journal: Vaccine

PubMed ID: 38749821

Doi: 10.1016/j.vaccine.2024.04.080

Products & Services: Molecular Biology Reagents

Automated optimization of the solubility of a hyper-stable α-amylase

Authors: Montader Ali, Matthew Greenig, Marc Oeller, Misha Atkinson, Xing Xu, Pietro Sormanni

Journal: Open Biol

PubMed ID: 38745462

Doi: 10.1098/rsob.240014

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Functional and biochemical characterisation of remote homologues of type IV pili proteins PilN and PilO in Helicobacter pylori

Authors: Sharmin Q Bonny, Xiaotian Zhou, Mohammad F Khan, Mohammad M Rahman, Yue Xin, Naveen Vankadari, Alexandra Tikhomirova, Jihane Homman-Ludiye, Anna Roujeinikova

Journal: IUBMB Life

PubMed ID: 38748402

Doi: 10.1002/iub.2828

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Structural Insights into Subunit-Dependent Functional Regulation in Epithelial Sodium Channels

Authors: Alexandra Houser, Isabelle Baconguis

Journal: biorxiv

PubMed ID: 38853903

Doi: 10.1101/2024.05.28.595834

Products & Services: Molecular Biology Reagents

Tilapia head gelatins to stabilize fish oil emulsions and the effect of extraction methods

Authors: Li Li, Guangyi Kan, Jiawei Peng, Huan Gong, Ye Zi, Cuiping Shi, Xichang Wang, Jian Zhong

Journal: Int J Biol Macromol

PubMed ID: 38734350

Doi: 10.1016/j.ijbiomac.2024.132137

Products & Services: Protein and Antibody Isolation

CaptureSelect FcXP affinity medium exhibits strong aggregate separation capability

Authors: Wanyuan Dong, Dan Zhang, Yifeng Li

Journal: Protein Expr Purif

PubMed ID: 38759705

Doi: 10.1016/j.pep.2024.106503

Products & Services: Protein Electrophoresis and Western

COVID-19 vaccination before or during pregnancy results in high, sustained maternal neutralizing activity to SARS-CoV-2 wild-type and Delta/Omicron variants of concern, particularly following a booster dose or infection

Authors: Aniza P Mahyuddin, Hannah L F Swa, Ruifen Weng, Jingxian Zhang, Janice P Dhanaraj, Binny P Sesurajan, Mary Rauff, Pradip Dashraath, Abhiram Kanneganti, Rachel Lee, Lin-Fa Wang, Barnaby E Young, Paul A Tambyah, David C Lye, Louis Y A Chai, Sidney Yee, Mahesh Choolani, Citra N Z Mattar

Journal: Int J Infect Dis

PubMed ID: 38823622

Doi: 10.1016/j.ijid.2024.107121

Products & Services: Molecular Biology Reagents

Variation in structural motifs within SARS-related coronavirus spike proteins

Authors: Francesca R Hills, Alice-Roza Eruera, James Hodgkinson-Bean, Fátima Jorge, Richard Easingwood, Simon H J Brown, James C Bouwer, Yi-Ping Li, Laura N Burga, Mihnea Bostina

Journal: PLoS Pathog

PubMed ID: 38805567

Doi: 10.1371/journal.ppat.1012158

Products & Services: Protein and Antibody Isolation

Structure of the lens MP20 mediated adhesive junction

Authors: William J Nicolas, Anna Shiriaeva, Michael W Martynowycz, Angus C Grey, Yasmeen Ruma, Paul J Donaldson, Tamir Gonen

Journal: biorxiv

PubMed ID: 38798449

Doi: 10.1101/2024.05.13.594022

Products & Services: Protein and Antibody Isolation

Structural pharmacology and therapeutic potential of 5-methoxytryptamines

Authors: Audrey L Warren, David Lankri, Michael J Cunningham, Inis C Serrano, Lyonna F Parise, Andrew C Kruegel, Priscilla Duggan, Gregory Zilberg, Michael J Capper, Vaclav Havel, Scott J Russo, Dalibor Sames, Daniel Wacker

Journal: Nature

PubMed ID: 38720072

Doi: 10.1038/s41586-024-07403-2

Products & Services: Protein and Antibody Isolation

Author Correction: Elucidation of the structural basis for ligand binding and translocation in conserved insect odorant receptor co-receptors

Authors: Jody Pacalon, Guillaume Audic, Justine Magnat, Manon Philip, Jérôme Golebiowski, Christophe J Moreau, Jérémie Topin

Journal: Nat Commun

PubMed ID: 38782904

Doi: 10.1038/s41467-024-48896-9

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Proteomic and lipidomic landscape of the infrapatellar fat pad and its clinical significance in knee osteoarthritis

Authors: Bizhi Tu, Zheng Zhu, Peizhi Lu, Run Fang, Cheng Peng, Jun Tong, Rende Ning

Journal: Biochim Biophys Acta Mol Cell Biol Lipids

PubMed ID: 38788831

Doi: 10.1016/j.bbalip.2024.159513

Products & Services: Protein and Antibody Isolation

Impact of N-Glycosylation on Protein Structure and Dynamics Linked to Enzymatic C–H Activation in the M. oryzae Lipoxygenase

Authors: Chris Whittington, Ajay Sharma, S Gage Hill, Anthony T Iavarone, Brian M Hoffman, Adam R Offenbacher

Journal: Biochemistry

PubMed ID: 38690768

Doi: 10.1021/acs.biochem.4c00109

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Manganese-dependent transcription regulation by MntR and PerR in Thermus thermophilus HB8

Authors: John K Barrows, Kamya A Stubbs, Irina F Padilla-Montoya, Thomas C Leeper, Michael W Van Dyke

Journal: Mol Microbiol

PubMed ID: 38735869

Products & Services: Nucleic Acid Purification

Imaging the dynamics of messenger RNA with a bright and stable green fluorescent RNA

Authors: Fangting Zuo, Li Jiang, Ni Su, Yaqiang Zhang, Bingkun Bao, Limei Wang, Yajie Shi, Huimin Yang, Xinyi Huang, Ruilong Li, Qingmei Zeng, Zhengda Chen, Qiuning Lin, Yingping Zhuang, Yuzheng Zhao, Xianjun Chen, Linyong Zhu & Yi Yang

Journal: nature chemical biology

PubMed ID: 38783134

Doi: 10.1038/s41589-024-01629-x

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Quercetin induces itaconic acid-mediated M1/M2 alveolar macrophages polarization in respiratory syncytial virus infection

Authors: Li An , Qianwen Zhai , Keyu Tao , Yingcai Xiong , Weiying Ou , Ziwei Yu , Xingyu Yang , Jianjian Ji , Mengjiang Lu

Journal: Phytomedicine

PubMed ID: 38797031

Doi: 10.1016/j.phymed.2024.155761

Products & Services: Protein Electrophoresis and Western

Delineating organizational principles of the endogenous L-A virus by cryo-EM and computational analysis of native cell extracts

Authors: Lisa Schmidt, Christian Tüting, Fotis L Kyrilis, Farzad Hamdi, Dmitry A Semchonok, Gerd Hause, Annette Meister, Christian Ihling, Milton T Stubbs, Andrea Sinz, Panagiotis L Kastritis

Journal: Commun Biol

PubMed ID: 38730276

Doi: 10.1038/s42003-024-06204-7

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Immunogenicity Analysis and Identification of Potential T-Cell Epitopes in C129R Protein of African Swine Fever Virus

Authors: Wenzhu Zhai, Ying Huang, Yuheng He, Yuanyuan Chu, Chunhao Tao, Zhongbao Pang, Zhen Wang, Hongfei Zhu, Hong Jia

Journal: Microorganisms

PubMed ID: 38930438

Doi: 10.3390/microorganisms12061056

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F Nucleatum enhances oral squamous cell carcinoma proliferation via E-cadherin/β-Catenin pathway

Authors: Zhengrui Li, Yuan Liu, Xufeng Huang, Qi Wang, Rao Fu, Xutao Wen, Ji'an Liu, Ling Zhang

Journal: BMC Oral Health

PubMed ID: 38698370

Doi: 10.1186/s12903-024-04252-3

Products & Services: Protein and Antibody Isolation

Novel Multi-Antigen Orf-Virus-Derived Vaccine Elicits Protective Anti-SARS-CoV-2 Response in Monovalent and Bivalent Formats

Authors: Dominique Julien Burri, Louis Renz, Melanie Mueller, Felix Pagallies, Ute Klinkhardt, Ralf Amann, Madiha Derouazi

Journal: Vaccines (Basel)

PubMed ID: 38793740

Doi: 10.3390/vaccines12050490

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Detection of SARS-CoV-2-Specific Secretory IgA and Neutralizing Antibodies in the Nasal Secretions of Exposed Seronegative Individuals

Authors: Jason S Chwa, Minjun Kim, Yesun Lee, Wesley A Cheng, Yunho Shin, Jaycee Jumarang, Jeffrey M Bender, Pia S Pannaraj

Journal: Viruses

PubMed ID: 38932145

Doi: 10.3390/v16060852

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Structural basis of nearest-neighbor cooperativity in the ring-shaped gene regulatory protein TRAP from protein engineering and cryo-EM

Authors: Weicheng Li, Haoyun Yang, Kye Stachowski, Andrew S Norris, Katie Lichtenthal, Skyler Kelly, Paul Gollnick, Vicki H Wysocki, Mark P Foster

Journal: biorxiv

PubMed ID: 38746386

Doi: 10.1101/2024.05.02.592192

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A fluorescence anisotropy-based competition assay to identify inhibitors against ricin and Shiga toxin ribosome interactions

Authors: Arkajyoti Dutta, Zoltan Szekely, Hakan Guven, Xiao-Ping Li, John E McLaughlin, Nilgun E Tumer

Journal: Anal Biochem

PubMed ID: 38825159

Doi: 10.1016/j.ab.2024.115580

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Citrus psorosis virus 24K protein inhibits the processing of miRNA precursors by interacting with components of the biogenesis machinery

Authors: Facundo E Marmisolle, María B Borniego, Damián A Cambiagno, Lucia Gonzalo, María L García, Pablo A Manavella, Carmen Hernández, Carina A Reyes

Journal: Microbiol Spectr

PubMed ID: 38785434

Doi: 10.1128/spectrum.03513-23

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LINE-1 retrotransposons contribute to mouse PV interneuron development

Authors: Gabriela O Bodea, Juan M Botto, Maria E Ferreiro, Francisco J Sanchez-Luque, Jose de Los Rios Barreda, Jay Rasmussen, Muhammed A Rahman, Laura R Fenlon, Natasha Jansz, Carolina Gubert, Patricia Gerdes, Liviu-Gabriel Bodea, Prabha Ajjikuttira, Darwin J Da Costa Guevara, Linda Cumner, Charles C Bell, Peter Kozulin, Victor Billon, Santiago Morell, Marie-Jeanne H C Kempen, Chloe J Love, Karabi Saha, Lucy M Palmer, Adam D Ewing, Dhanisha J Jhaveri, Sandra R Richardson, Anthony J Hannan, Geoffrey J Faulkner

Journal: Nat Neurosci

PubMed ID: 38773348

Doi: 10.1038/s41593-024-01650-2

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