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Applying valency-based immuno-selection to generate broadly cross-reactive antibodies against influenza hemagglutinins

Authors: Daniëla Maria Hinke, Ane Marie Anderson, Kirankumar Katta, Marlene Fyrstenberg Laursen, Demo Yemane Tesfaye, Ina Charlotta Werninghaus, Davide Angeletti, Gunnveig Grødeland, Bjarne Bogen, Ranveig Braathen

Journal: Nat Commun

PubMed ID: 38346952

Doi: 10.1038/s41467-024-44889-w

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Evaluation of the therapeutic effect of a novel bacteriophage in the healing process of infected wounds with Klebsiella pneumoniae in mice

Authors: Fatemeh Zeynali Kelishomi, Farhad Nikkhahi, Samira Amereh, Fatemeh Ghayyaz, Seyed Mahmoud Amin Marashi, Amir Javadi, Gholamhassan Shahbazi, Mohadeseh Khakpour

Journal: J Glob Antimicrob Resist

PubMed ID: 38307250

Doi: 10.1016/j.jgar.2024.01.018

Products & Services: Molecular Biology Reagents

Structural and functional comparisons of salivary α-glucosidases from the mosquito vectors Aedes aegypti, Anopheles gambiae, and Culex quinquefasciatus

Authors: Adeline E Williams, Apostolos G Gittis, Karina Botello, Phillip Cruz, Ines Martin-Martin, Paola Carolina Valenzuela Leon, Benjamin Sumner, Brian Bonilla, Eric Calvo

Journal: Insect Biochem Mol Biol

PubMed ID: 38428508

Doi: 10.1016/j.ibmb.2024.104097

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The catalytic action of human d-lactate dehydrogenase is severely inhibited by oxalate and is impaired by mutations triggering d-lactate acidosis

Authors: Alessandra Stefan, Alberto Mucchi, Alejandro Hochkoeppler

Journal: Arch Biochem Biophys

PubMed ID: 38373542

Doi: 10.1016/j.abb.2024.109932

Products & Services: Mutagenesis Services

Aberrant Upregulation of RUNX3 Activates Developmental Genes to Drive Metastasis in Gastric Cancer

Authors: Kazuto Suda, Atsushi Okabe, Junichi Matsuo, Linda Shyue Huey Chuang, Ying Li, Nawaphat Jangphattananont, Naing Naing Mon, Khine Nyein Myint, Akihiro Yamamura, Jimmy Bok-Yan So, Dominic Chih-Cheng Voon, Henry Yang, Khay Guan Yeoh, Atsushi Kaneda, Yoshiaki Ito

Journal: Cancer Res Commun

PubMed ID: 38240752

Doi: 10.1158/2767-9764.CRC-22-0165

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Development and characterization of DIA 123, a fully human intact anti-CEACAM1 monoclonal antibody

Authors: Michela Centonze, Valentina Fiori, Maciej Kujawski, Lin Li, Patty Wong, Lindsay Williams, Tomas Di Mambro, Sabrina Dominici, Angelo Sparti, John E Shively, Mauro Magnani

Journal: PLoS ONE

PubMed ID: 38346003

Doi: 10.1371/journal.pone.0295345

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Cloning and phylogenetic analysis of N protein gene from Rift Valley Fever Virus (RVFV)

Authors: Ahmed Mohamed Hassan, Arwa Ahmed Zehairy, Al-Judaibi Awatif Abid, Sayed Sartaj Sohrab, Ibraheem Azhar Esam

Journal: Bioinformation

PubMed ID: 38497067

Doi: 10.6026/973206300200091

Products & Services: Molecular Biology Reagents

Graphene Quantum Dots (GQD)-Mediated dsRNA Delivery for the Control of Fusarium Head Blight Disease in Wheat

Authors: Binod Gyawali, Rahim Rahimi, Houshang Alizadeh, Mohsen Mohammadi

Journal: ACS Appl Bio Mater

PubMed ID: 38422985

Doi: 10.1021/acsabm.3c00972

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Ebselen and TPI-1, as RecG helicase inhibitors, potently enhance the susceptibility of Pseudomonas aeruginosa to DNA damage agents

Authors: Longheng Li, Binbin Guo, Lin Dai, Chun Liu, Zhonghui Lin

Journal: Biochem Pharmacol

PubMed ID: 38354956

Doi: 10.1016/j.bcp.2024.116051

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miR-30e-5p regulates leukemia stem cell self-renewal through the Cyb561/ROS signaling pathway

Authors: Yanwen Ge, Mei Hong, Yu Zhang, Jiachen Wang, Lei Li, Hongkai Zhu, Yue Sheng, Wen-Shu Wu, Zhonghui Zhang

Journal: Haematologica

PubMed ID: 37584287

Doi: 10.3324/haematol.2023.282837

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PDGFRβ-Antagonistic Affibody-Mediated Tumor-Targeted Tumor Necrosis Factor-Alpha for Enhanced Radiotherapy in Lung Cancer

Authors: Xiaohui Tang, Jie Chen, Zhenxiong Zhao, Jie Liu, Ranfei Yu, Kunlong Zhao, Fei Wang, Yang Li, Baoqing Tian, Dandan Yuan, Yuguo Liu, Qing Fan

Journal: Mol Pharm

PubMed ID: 38364870

Doi: 10.1021/acs.molpharmaceut.3c00869

Products & Services: Proteins, Expression, Isolation and Analysis

Evaluation of nucleotide MALDI-TOF-MS for the identification of species

Authors: Yelei Zhu, Zhengwei Liu, Lina Peng, Bin Liu, Kunyang Wu, Mingwu Zhang, Xiaomeng Wang, Junhang Pan

Journal: Front Cell Infect Microbiol

PubMed ID: 38379773

Doi: 10.3389/fcimb.2024.1335104

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Development, validation and application of an ion-pair reversed-phase liquid chromatography-tandem mass spectrometry method for the quantification of nusinersen

Authors: Xiao Zhang, Chunjie Sha, Wei Zhang, Fengjuan Zhao, Mingli Zhu, Guangyi Leng, Wanhui Liu

Journal: Bioanalysis

PubMed ID: 38334103

Doi: 10.4155/bio-2023-0218

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African swine fever virus pH240R enhances viral replication via inhibition of the type I IFN signaling pathway

Authors: Guangqiang Ye, Zhaoxia Zhang, Xiaohong Liu, Hongyang Liu, Weiye Chen, Chunying Feng, Jiangnan Li, Qiongqiong Zhou, Dongming Zhao, Shuai Zhang, Hefeng Chen, Zhigao Bu, Li Huang, Changjiang Weng

Journal: J Virol

PubMed ID: 38353534

Doi: 10.1128/jvi.01834-23

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Multitrait engineering of Hassawi red rice for sustainable cultivation

Authors: Khalid Sedeek, Nahed Mohammed, Yong Zhou, Andrea Zuccolo, Krishnaveni Sanikommu, Sunitha Kantharajappa, Noor Al-Bader, Manal Tashkandi, Rod A Wing, Magdy M Mahfouz

Journal: Plant Sci

PubMed ID: 38325660

Doi: 10.1016/j.plantsci.2024.112018

Improvement of Carotenoids' Production by Increasing the Activity of Beta-Carotene Ketolase with Different Strategies

Authors: Qiaomian Zhou, Danqiong Huang, Haihong Yang, Zeyu Hong, Chaogang Wang

Journal: Microorganisms

PubMed ID: 38399781

Doi: 10.3390/microorganisms12020377

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Effectiveness of a broad-spectrum bivalent mRNA vaccine against SARS-CoV-2 variants in preclinical studies

Authors: Jing Lu, Shudan Tan, Hao Gu, Kunpeng Liu, Wei Huang, Zhaoli Yu, Guoliang Lu, Zihan Wu, Xiaobo Gao, Jinghua Zhao, Zongting Yao, Feng Yi, Yantao Yang, Hu Wang, Xue Hu, Mingqing Lu, Wei Li, Hui Zhou, Hang Yu, Chao Shan, Jinzhong Lin

Journal: Emerg Microbes Infect

PubMed ID: 38377136

Doi: 10.1080/22221751.2024.2321994

Products & Services: Proteins, Expression, Isolation and Analysis

Supramolecular self-assembly strategies of natural-based β-lactoglobulin modulating bitter perception of goat milk-derived bioactive peptides

Authors: Rong Zhang, Wei Jia

Journal: J Dairy Sci

PubMed ID: 38310962

Doi: 10.3168/jds.2023-24386

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Atypical Plant miRNA cal-miR2911: Robust Stability against Food Digestion and Specific Promoting Effect on in Mice

Authors: Qin Xu, Jianing Wang, Yi Zhang, Ying Li, Xinshu Qin, Yirao Xin, Yinglei Li, Ke Xu, Xingbin Yang, Xingyu Wang

Journal: J Agric Food Chem

PubMed ID: 38393993

Doi: 10.1021/acs.jafc.3c09511

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Using for High-Yield Production of Challenging Expression Targets and for Protein Perdeuteration

Authors: Natalia Mojica, Flore Kersten, Mateu Montserrat-Canals, G Robb Huhn Iii, Abelone M Tislevoll, Gabriele Cordara, Ken Teter, Ute Krengel

Journal: Biochemistry

PubMed ID: 38359344

Doi: 10.1021/acs.biochem.3c00612

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CRISPR Ribonucleoprotein-Mediated Precise Editing of Multiple Genes in Porcine Fibroblasts

Authors: Xiaochen Guo, Chang Liu, Yunjing Zhao, Chaoqian Jiang, Junxue Jin, Zhonghua Liu, Yanshuang Mu

Journal: Animals (Basel)

PubMed ID: 38396618

Doi: 10.3390/ani14040650

Products & Services: Gene Synthesis

Vaccine Based on Recombinant Fusion Protein Combining Hepatitis B Virus PreS with SARS-CoV-2 Wild-Type- and Omicron-Derived Receptor Binding Domain Strongly Induces Omicron-Neutralizing Antibodies in a Murine Model

Authors: Pia Gattinger, Bernhard Kratzer, Al Nasar Ahmed Sehgal, Anna Ohradanova-Repic, Laura Gebetsberger, Gabor Tajti, Margarete Focke-Tejkl, Mirjam Schaar, Verena Fuhrmann, Lukas Petrowitsch, Walter Keller, Sandra Högler, Hannes Stockinger, Winfried F Pickl, Rudolf Valenta

Journal: Vaccines (Basel)

PubMed ID: 38543863

Doi: 10.3390/vaccines12030229

Products & Services: Recombinant Proteins

NK-92MI Cells Engineered with Anti-claudin-6 Chimeric Antigen Receptors in Immunotherapy for Ovarian Cancer

Authors: Junping Li, Hong Hu, Hui Lian, Shuo Yang, Manting Liu, Jinping He, Bihui Cao, Dongni Chen, Yuling Hu, Chen Zhi, Yan Shen, Xiaodie Ye, Bingjia He, Ming Zhao, Weijun Fan, Linfeng Xu, Rom Leidner, Qingde Wu, Lili Yang, Zhenfeng Zhang

Journal: Int J Biol Sci

PubMed ID: 38481806

Doi: 10.7150/ijbs.88539

Products & Services: Gene Synthesis

NEAT1 repression by MED12 creates chemosensitivity in p53 wild-type breast cancer cells

Authors: Shengjie Zhang, Eui-Jun Kim, Junfeng Huang, Peng Liu, Kristine Donahue, Qinchuan Wang, Yidan Wang, Sean Mcilwain, Ling Xie, Xian Chen, Lingjun Li, Wei Xu

Journal: FEBS J

PubMed ID: 38380720

Doi: 10.1111/febs.17097

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Creation of a point-of-care therapeutics sensor using protein engineering, electrochemical sensing and electronic integration

Authors: Rong Cai, Chiagoziem Ngwadom, Ravindra Saxena, Jayashree Soman, Chase Bruggeman, David P Hickey, Rafael Verduzco, Caroline M Ajo-Franklin

Journal: Nat Commun

PubMed ID: 38402222

Doi: 10.1038/s41467-024-45789-9

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Polycomb repression of Hox genes involves spatial feedback but not domain compaction or phase transition

Authors: Sedona Eve Murphy, Alistair Nicol Boettiger

Journal: Nat Genet

PubMed ID: 38361032

Doi: 10.1038/s41588-024-01661-6

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Performance of Three Anti-SARS-CoV-2 Anti-S and One Anti-N Immunoassays for the Monitoring of Immune Status and Vaccine Response

Authors: Y Victoria Zhang, Attila Kumanovics, Joesph Wiencek, Stacy E F Melanson, Tanzy Love, Alan H B Wu, Zhen Zhao, Qing H Meng, David D Koch, Fred S Apple, Caitlin R Ondracek, Robert H Christenson

Journal: Viruses

PubMed ID: 38400067

Doi: 10.3390/v16020292

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Long noncoding RNA TMPO-AS1 accelerates glycolysis by regulating the miR-1270/PKM2 axis in colorectal cancer

Authors: Yingmin Jin, Aimin Jiang, Liying Sun, Yue Lu

Journal: BMC Cancer

PubMed ID: 38383342

Doi: 10.1186/s12885-024-11964-w

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CD46 and CD59 inhibitors enhance complement-dependent cytotoxicity of anti-CD38 monoclonal antibodies daratumumab and isatuximab in multiple myeloma and other B-cell malignancy cells

Authors: Hongjie Wang, Theo Koob, Jonathan R Fromm, Ajay Gopal, Darrick Carter, André Lieber

Journal: Cancer Biol Ther

PubMed ID: 38361357

Doi: 10.1080/15384047.2024.2314322

Products & Services: Proteins, Expression, Isolation and Analysis

Discovery and Characterization of Selective, First-in-Class Inhibitors of Citron Kinase

Authors: Joshua J Maw, Jesse A Coker, Tarun Arya, Christopher M Goins, Dhiraj Sonawane, Sang Hoon Han, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Nancy S Wang, Hannelore V Heemers, Jonathan D Macdonald, Shaun R Stauffer

Journal: J Med Chem

PubMed ID: 38330278

Doi: 10.1021/acs.jmedchem.3c01807

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mTOR Regulates Mineralocorticoid Receptor Transcriptional Activity by ULK1-Dependent and -Independent Mechanisms

Authors: Yusuf Ali, Celso E Gomez-Sanchez, Maria Plonczynski, Aniko Naray-Fejes-Toth, Geza Fejes-Toth, Elise P Gomez-Sanchez

Journal: Endocrinology

PubMed ID: 38325289

Doi: 10.1210/endocr/bqae015

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Exploring the immunogenicity of Rv2201-519: A T-cell epitope-based antigen derived from Mycobacterium tuberculosis AsnB with implications for tuberculosis infection detection and vaccine development

Authors: Xiuli Luan, Xueting Fan, Guilian Li, Mchao Li, Na Li, Yuhan Yan, Xiuqin Zhao, Haican Liu, Kanglin Wan

Journal: Int Immunopharmacol

PubMed ID: 38342063

Doi: 10.1016/j.intimp.2024.111542

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Discovery of Two Novel Immunoepitopes and Development of Peptide-based Sarcoidosis Immunoassay

Authors: Changya Peng , Jaya Talreja , Brennen Steinbauer , Kazuhiko Shinki , Laura L Koth , Lobelia Samavati

Journal: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

PubMed ID: 38385694

Doi: 10.1164/rccm.202306-1054OC

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Bicistronic expression of nuclear transgenes in Chlamydomonas reinhardtii

Authors: Nick Jacobebbinghaus, Kyle J Lauersen, Olaf Kruse, Thomas Baier

Journal: the plant journal

PubMed ID: 38415961

Doi: 10.1111/tpj.16677

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SPR spectroscopic analysis of myosin binding to wild type and mutant UNC45B

Authors: Silvana Valdebenito, Eliseo Eugenin, Andres Oberhauser

Journal: MicroPubl Biol

PubMed ID: 38404916

Doi: 10.17912/micropub.biology.001131

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Architecture and flexibility of native kinetochores revealed by structural studies utilizing a thermophilic yeast

Authors: Daniel J Barrero, Sithara S Wijeratne, Xiaowei Zhao, Grace F Cunningham, Yan Rui, Christian R Nelson, Arimura Yasuhiro, Hironori Funabiki, Charles L Asbury, Zhiheng Yu, Radhika Subramanian, Sue Biggins

Journal: biorxiv

PubMed ID: 38464254

Doi: 10.1101/2024.02.28.582571

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NY-ESO-1-specific T cell receptor-engineered T cells and Tranilast, a TRPV2 antagonist bivalent treatment enhances the killing of esophageal cancer: a dual-targeted cancer therapeutic route

Authors: Obed Boadi Amissah, Wenfang Chen, Jean de Dieu Habimana, Yirong Sun, Lihui Lin, Yujie Liu, Ling Wang, Zhaoming Liu, Omar Mukama, Rajesh Basnet, Hohua Liu, Junyi Li, Xuanyan Ding, Lingshuang Lv, Min Chen, Yalin Liang, Rongqi Huang, Zhiyuan Li

Journal: Cancer Cell Int

PubMed ID: 38336680

Doi: 10.1186/s12935-024-03249-w

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CD39 tumor infiltrating T cells from colorectal cancers exhibit dysfunctional phenotype

Authors: Yuan Feng, Xin Xu, Jiaxin Zhang, Christopher Sanderson, Jun Xia, Zhang Bu, Yili Yang, Peng Yang, Zhiliang Lu

Journal: Am J Cancer Res

PubMed ID: 38455401

Doi: 10.62347/IZEN3736

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A Direct Comparison of rAAV5 Variants Derived from the Baculovirus Expression System Using LC-MS Workflows Demonstrates Key Differences in Overall Production Yield, Product Quality and Vector Efficiency

Authors: Felipe Guapo, Nicholas Donohue, Lisa Strasser, Stefano Boi, Florian Füssl, Alana Rainbow-Fletcher, Paul Getty, Ian Anderson, Niall Barron, Jonathan Bones

Journal: Int J Mol Sci

PubMed ID: 38474031

Doi: 10.3390/ijms25052785

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Seroprevalence of IgM/IgG and Neutralizing Antibodies against SARS-CoV-2 in Unvaccinated Young Adults from Mexico Who Reported Not Having Had a Previous COVID-19 Infection

Authors: Diana Lourdes Padilla-Bórquez, Mónica Guadalupe Matuz-Flores, Jorge Hernández-Bello, Gabriela Athziri Sánchez-Zuno, Samuel García-Arellano, Edith Oregon-Romero, Melva Guadalupe Herrera-Godina, Guillermo González-Estevez, Norma Patricia Adan-Bante, Jesús Alfredo Rosas-Rodríguez, José Francisco Muñoz-Valle

Journal: Can J Infect Dis Med Microbiol

PubMed ID: 38384428

Doi: 10.1155/2024/8871439

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Distinct structural variants and repeat landscape shape the genomes of the ancient grapes Aglianico and Falanghina

Authors: Riccardo Aversano, Marina Iovene , Salvatore Esposito , Alberto L'Abbate , Clizia Villano , Ermanno Di Serio , Maria Francesca Cardone , Carlo Bergamini , Riccardo Aiese Cigliano , Vincenzo D'Amelia , Luigi Frusciante , Domenico Carputo

Journal: BMC Plant Biol.

PubMed ID: 38317087

Doi: 10.1186/s12870-024-04778-2

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Structure-guided engineering enables E3 ligase-free and versatile protein ubiquitination via UBE2E1

Authors: Xiangwei Wu, Yunxiang Du, Lu-Jun Liang, Ruichao Ding, Tianyi Zhang, Hongyi Cai, Xiaolin Tian, Man Pan, Lei Liu

Journal: Nat Commun .

PubMed ID: 38341401

Doi: 10.1038/s41467-024-45635-y

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Mage Transposon: A Novel Gene Delivery System for Mammalian Cells

Authors: Jinghan Tian, Doudou Tong, Zhendong Li, Erqiang Wang, Yifei Yu, Hangya Lv, Zhendan Hu, Fang Sun, Guoping Wang, Min He, Tian Xia

Journal: Nucleic Acids Res .

PubMed ID: 38300794

Doi: 10.1093/nar/gkae048

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An oncolytic virus–T cell chimera for cancer immunotherapy

Authors: Yuxuan Chen , Xiaohong Chen , Weier Bao , Gang Liu , Wei Wei , Yuan Ping

Journal: Nat Biotechnol .

PubMed ID: 38336902

Doi: 10.1038/s41587-023-02118-7

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A Gamma-adapted subunit vaccine induces broadly neutralizing antibodies against SARS-CoV-2 variants and protects mice from infection

Authors: Lorena M Coria , Juan Manuel Rodriguez , Agostina Demaria , Laura A Bruno , Mayra Rios Medrano , Celeste Pueblas Castro , Eliana F Castro , Sabrina A Del Priore , Andres C Hernando Insua , Ingrid G Kaufmann , Lucas M Saposnik , William B Stone , Lineia Prado , Ulises S Notaro , Ayelen N Amweg , Pablo U Diaz , Martin Avaro , Hugo Ortega , Ana Ceballos , Valeria Krum , Francisco M Zurvarra , Johanna E Sidabra , Ignacio Drehe , Jonathan A Baqué , Mariana Li Causi , Analia V De Nichilo , Cristian J Payes , Teresa Southard , Julio C Vega , Albert J Auguste , Diego E Álvarez , Juan M Flo , Karina A Pasquevich , Juliana Cassataro

Journal: Nat Commun

PubMed ID: 38307851

Doi: 10.1038/s41467-024-45180-8

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The chromatin-associated lncREST ensures effective replication stress response by promoting the assembly of fork signaling factors

Authors: Luisa Statello , José Miguel Fernandez-Justel , Jovanna González , Marta Montes , Alessia Ranieri , Enrique Goñi , Aina M Mas , Maite Huarte

Journal: Nat Commun

PubMed ID: 38302450

Doi: 10.1038/s41467-024-45183-5

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Longitudinal single-cell transcriptional dynamics throughout neurodegeneration in SCA1

Authors: Leon Tejwani, Neal G Ravindra, Changwoo Lee, Yubao Cheng, Billy Nguyen, Kimberly Luttik, Luhan Ni, Shupei Zhang, Logan M Morrison, John Gionco, Yangfei Xiang, Jennifer Yoon, Hannah Ro, Fatema Haidery, Rosalie M Grijalva, Eunwoo Bae, Kristen Kim , Regina T Martuscello, Harry T Orr, Huda Y Zoghbi , Hayley S McLoughlin, Laura P W Ranum, Vikram G Shakkottai, Phyllis L Faust, Siyuan Wang, David van Dijk, Janghoo Lim

Journal: Neuron

PubMed ID: 38016472

Doi: 10.1016/j.neuron.2023.10.039

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Discoveries of GPR39 as an evolutionarily conserved receptor for bile acids and of its involvement in biliary acute pancreatitis

Authors: Zhentao Zi 1 2, Yi Rao

Journal: Sci Adv

PubMed ID: 38306436

Doi: 10.1126/sciadv.adj0146

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Essential functions of Inositol hexakisphosphate (IP6) in Murine Leukemia Virus replication

Authors: Banhi Biswas, Kin Kui Lai, Harrison Bracey, Siddhartha A K Datta, Demetria Harvin, Gregory A Sowd, Christopher Aiken, Alan Rein

Journal: biorxiv

PubMed ID: 38464197

Doi: 10.1101/2024.02.27.581940

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Examination of SARS-CoV-2 serological test results from multiple commercial and laboratory platforms with an in-house serum panel

Authors: Sandra N Lester, Megan Stumpf, Brandi D Freeman, Lisa Mills, Jarad Schiffer, Vera Semenova, Tao Jia, Rita Desai, Peter Browning, Bailey Alston, Muyiwa Ategbole, Shanna Bolcen, Alexander Chen, Ebenezer David, Panagiotis Manitis, Heather Tatum, Yunlong Qin, Briana Zellner, Jan Drobeniuc, Alexandra Tejada-Strop, Payel Chatterjee, Punya Shrivastava-Ranjan, M Harley Jenks, Laura K McMullan, Mike Flint, Christina F Spiropoulou, Glenn P Niemeyer, Bonnie J Werner, Christopher J Bean, Jeffrey A Johnson, Alex R Hoffmaster, Panayampalli S Satheshkumar, Amy J Schuh, S Michele Owen, Natalie J Thornburg

Journal: Access Microbiol

PubMed ID: 38482357

Doi: 10.1099/acmi.0.000463.v4

Products & Services: Proteins, Expression, Isolation and Analysis

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