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Molecular basis of lipid and ligand regulation of prostaglandin receptor DP2

Authors: Jiuyin Xu , Youwei Xu , Li Hou , Xinheng He , Yang Li , Jing Zhao , Xue Meng , James Jiqi Wang , Yanli Wu , Heng Zhang , Yunhai Li , Wen Hu , Qingning Yuan , Kai Wu , Xi Cheng , Yi Jiang , Yu Xia , H Eric Xu , Canrong Wu

Journal: Proc Natl Acad Sci U S A .

PubMed ID: 39665758

Doi: 10.1073/pnas.2403304121

Products & Services: Protein and Antibody Isolation

An Integrated Whole-Process Repair System with Programmed Regulation of Healing Performance Facilitates Urethral Wound Restoration and Scarless Reconstruction

Authors: Wenzhuo Fang , Ying Wang , Kaile Zhang , Ming Yang , Meng Liu , Yangwang Jin , Xianjie Xiu , Yuhui Wang , Zhenwei Yu , Ranxing Yang , Qiang Fu

Journal: Adv Sci (Weinh)

PubMed ID: 39691071

Doi: 10.1002/advs.202409930

Products & Services: Peptide Synthesis

SPP1+ macrophages promote head and neck squamous cell carcinoma progression by secreting TNF-α and IL-1β

Authors: Chun Liu , Kun Wu , Chuwen Li , Zhen Zhang , Peisong Zhai , Haiyan Guo , Jianjun Zhang

Journal: J Exp Clin Cancer Res

PubMed ID: 39726047

Doi: 10.1186/s13046-024-03255-w

Products & Services: Protein Electrophoresis and Western

Dual-Targeted Protein MRI Contrast Agent for Early

Authors: Ruofan Hu, Zhiyang Wang, Tinghui Shen, Qianwen Yang, Weizhi Chen, Xiqun Jiang

Journal: Aggregate

Doi: 10.1002/agt2.732

Products & Services: Protein and Antibody Isolation

Multiplexed Assays of Variant Effect and Automated Patch Clamping Improve KCNH2-LQTS Variant Classification and Cardiac Event Risk Stratification

Authors: Matthew J O'Neill, Chai-Ann Ng, Takanori Aizawa, Luca Sala, Sahej Bains, Annika Winbo, Rizwan Ullah, Qianyi Shen, Chek-Ying Tan, Krystian Kozek, Loren R Vanags, Devyn W Mitchell, Alex Shen, Yuko Wada, Asami Kashiwa, Lia Crotti, Federica Dagradi, Giulia Musu, Carla Spazzolini, Raquel Neves, J Martijn Bos, John R Giudicessi, Xavier Bledsoe, Eric R Gamazon, Megan C Lancaster, Andrew M Glazer, Bjorn C Knollmann, Dan M Roden, Jochen Weile, Frederick Roth, Joe-Elie Salem, Nikki Earle, Rachael Stiles, Taylor Agee, Christopher N Johnson, Minoru Horie, Jonathan R Skinner, Michael J Ackerman, Peter J Schwartz, Seiko Ohno, Jamie I Vandenberg, Brett M Kroncke

Journal: Circulation

PubMed ID: 39315434

Doi: 10.1161/CIRCULATIONAHA.124.069828

Products & Services: PCR Cloning and Subcloning

Cryo-EM structure of Nipah virus RNA polymerase complex

Authors: Yiru Wang, Lixia Zhao, Yi Zhang, Yuhan Wang, Jiao Tang, Simiao Liu, Huihan Gao, Xiaoxiao Zhang, Luca Zinzula, Roger D Kornberg, Heqiao Zhang

Journal: SCIENCE ADVANCES

PubMed ID: 39661676

Doi: 10.1126/sciadv.adr7116

Products & Services: Gene Synthesis Codon Optimization

Supramolecular complexes of GCAP1: implications for inherited retinal dystrophies

Authors: Amedeo Biasi, Valerio Marino, Giuditta Dal Cortivo, Daniele Dell'Orco

Journal: International Journal of Biological Macromolecules

PubMed ID: 39187109

Doi: doi.org/10.1016/j.ijbiomac.2024.135068

Products & Services: Peptide Synthesis PCR Cloning and Subcloning Mutagenesis Services

Tuning the Sensitivity of MoS2 Nanopores: From Labeling to Labeling-Free Detection of DNA Methylation

Authors: Chunxiao Zhao, Yibo Yang, Pinlong Zhao, Chongbin Shi, Tianhui Tan, Hongzhen Bai, Jiandong Feng

Journal: Small Methods

PubMed ID: 39555656

Doi: 10.1002/smtd.202401532

Products & Services: Gene Synthesis Bacterial Expression

An intracellular bacterial pathogen triggers RIG-I/ MDA5-dependent necroptosis

Authors: Hang Xu , Huili Li , Boguang Sun,, Li Sun

Journal: Current Research in Microbial Sciences

Doi: doi.org/10.1016/j.crmicr.2024.100318

Products & Services: Protein and Antibody Isolation

Chemoenzymatic Synthesis of the Cyclopiane Family of Diterpenoid Natural Products

Authors: Zhengren Xu, Tao Wang, Jiasheng Zou, Kaibiao Wang, Yuanning Liu, Shouqi Zhang, Yao Kong

Journal: Angew Chem Int Ed Engl

PubMed ID: 39601390

Doi: 10.1002/anie.202419092

Products & Services: Gene Synthesis

Reduced cross-protective potential of Omicron compared to ancestral SARS-CoV-2 spike vaccines against potentially zoonotic coronaviruses.

Authors: Tyler M. Renner, Matthew Stuible, Brian Cass, Sylvie Perret, Julie Guimond, Simon Lord-Dufour, Michael J. McCluskie, Yves Durocher & Bassel Akache

Journal: npj Viruses

Doi: 10.1038/s44298-024-00067-9

Products & Services: Gene Synthesis

Interactomic exploration of LRRC8A in volume-regulated anion channels

Authors: Veronica Carpanese; Margherita Festa; Elena Prosdocimi; Magdalena Bachmann; Soha Sadeghi; Sara Bertelli; Frank Stein; Angelo Velle; Mostafa A. L. Abdel-Salam; Chiara Romualdi; Michael Pusch; Vanessa Checchetto

Journal: Cell death discovery

PubMed ID: 38909013

Doi: 10.1038/s41420-024-02032-0

Products & Services: Protein Electrophoresis and Western

KIX domain determines a selective tumor-promoting role for EP300 and its vulnerability in small cell lung cancer

Authors: Kee-Beom Kim; Ashish Kabra; Dong-Wook Kim; Yongming Xue; Yuanjian Huang; Pei-Chi Hou; Yunpeng Zhou; Leilani J. Miranda; Jae-Il Park; Xiaobing Shi; Timothy P. Bender; John H. Bushweller; Kwon-Sik Park

Journal: SCIENCE ADVANCES

PubMed ID: 35171684

Doi: 10.1126/sciadv.abl4618

Engineering of Peptide Inserted Base Editors with Enhanced Accuracy and Security

Authors: Qi Chen; Yangning Sun; Jia Yao; Yingfan Lu; Ruikang Qiu; Fuling Zhou; Zixin Deng; Yuhui Sun

Journal: Small (Weinheim an der Bergstrasse, Germany)

PubMed ID: 39995348

Doi: 10.1002/smll.202411583

Expression and functional study of DNA polymerases from Psychrobacillus sp. BL-248-WT-3 and FJAT-21963

Authors: Yaping Sun , Danny Hsu Ko , Jie Gao , Kang Fu , Yuanchen Mao , Yun He , Hui Tian

Journal: Front Microbiol

PubMed ID: 39633807

Doi: doi.org/10.3389/fmicb.2024.1501020

Products & Services: Gene Synthesis

Computation-driven redesign of an NRPS-like carboxylic acid reductase improves activity and selectivity

Authors: Kun Shi, Ju-Mou Li, Mu-Qiang Wang, Yi-Ke Zhang, Zhi-Jun Zhang, Qi Chen, Frank Hollmann, Jian-He Xu, Hui-Lei Yu

Journal: SCIENCE ADVANCES

PubMed ID: 39612335

Doi: 10.1126/sciadv.adp6775

Products & Services: Gene Synthesis

Compartmentalized Sesquiterpenoid Biosynthesis and Functionalization in the Chlamydomonas reinhardtii Plastid

Authors: Sergio Gutiérrez, Sebastian Overmans, Gordon B. Wellman, Kyle J. Lauersen

Journal: Chemistry Europe

Doi: 10.1002/cbic.202400902

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KIX domain determines a selective tumor-promoting role for EP300 and its vulnerability in small cell lung cancer

Journal: SCIENCE ADVANCES

PubMed ID: 35171684

Doi: 10.1126/sciadv.abl4618

Engineering of Peptide Inserted Base Editors with Enhanced Accuracy and Security

Authors: Qi Chen; Yangning Sun; Jia Yao; Yingfan Lu; Ruikang Qiu; Fuling Zhou; Zixin Deng; Yuhui Sun

Journal: Small (Weinheim an der Bergstrasse, Germany)

PubMed ID: 39995348

Doi: 10.1002/smll.202411583

An Isopentenol Utilization Pathway-Based “Deuterium-Scanning“Method for Mechanistic Investigations of Terpene Cyclases

Authors: Shouqi Zhang, Kaibiao Wang,Yuanning Liu, Tao Wang, Yao Kong, Pengcheng Zhang, Bo Zhang, Min Yin, Guohui Pan, and Zhengren Xu

Journal: ACS catalysis

Doi: 10.1021/acscatal.4c05811

Products & Services: Gene Synthesis

Bivalent CD47 immunotoxin for targeted therapy of T-cell acute lymphoblastic leukemia

Authors: Jihong Ma , Zhaohui Wang , Danielle Mintzlaff , Huiping Zhang , Rashmi Ramakrishna , Eduardo Davila , Matthew T Witkowski , M Scott Lucia , Marc S Schwartz , Elizabeth A Pomfret , David W Mathes , Zhirui Wang

Journal: Blood

PubMed ID: 39561285

Doi: 10.1182/blood.2024025277

Products & Services: Gene Synthesis

Dysregulation of Streptococcus pneumoniae zinc homeostasis breaks ampicillin resistance in a pneumonia infection model

Authors: Erin B. Brazel; Aimee Tan; Stephanie L. Neville; Amy R. Iverson; Saumya R. Udagedara; Bliss A. Cunningham; Mwilye Sikanyika; David M.P. De Oliveira; Bernhard Keller; Lisa Bohlmann; Ibrahim M. El-Deeb; Katherine Ganio; Bart A. Eijkelkamp; Alastair G. McEwan; Mark von Itzstein; Megan J. Maher; Mark J. Walker; Jason W. Rosch; Christopher A. McDevitt

Journal: Cell Reports

PubMed ID: 35021083

Doi: 10.1016/j.celrep.2021.110202

Dysregulation of Streptococcus pneumoniae zinc homeostasis breaks ampicillin resistance in a pneumonia infection model

Journal: Cell Reports

PubMed ID: 35021083

Doi: 10.1016/j.celrep.2021.110202

Dysregulation of Streptococcus pneumoniae zinc homeostasis breaks ampicillin resistance in a pneumonia infection model

Journal: Cell Reports

PubMed ID: 35021083

Doi: 10.1016/j.celrep.2021.110202

KIX domain determines a selective tumor-promoting role for EP300 and its vulnerability in small cell lung cancer

Journal: SCIENCE ADVANCES

PubMed ID: 35171684

Doi: 10.1126/sciadv.abl4618

Dysregulation of Streptococcus pneumoniae zinc homeostasis breaks ampicillin resistance in a pneumonia infection model

Journal: Cell Reports

PubMed ID: 35021083

Doi: 10.1016/j.celrep.2021.110202

Engineering of Peptide Inserted Base Editors with Enhanced Accuracy and Security

Authors: Qi Chen; Yangning Sun; Jia Yao; Yingfan Lu; Ruikang Qiu; Fuling Zhou; Zixin Deng; Yuhui Sun

Journal: Small (Weinheim an der Bergstrasse, Germany)

PubMed ID: 39995348

Doi: 10.1002/smll.202411583

Oncogenic cholesterol rewires lipid metabolism in hepatocellular carcinoma via the CSNK2A1-IGF2R Ser2484 axis

Authors: Ren-Yi Su, Chen-Hao Xu, Hai-Jun Guo, Li-Jun Meng, Jian-Yong Zhuo, Nan Xu, Hui-Gang Li, Chi-Yu He, Xuan-Yu Zhang, Zheng-Xin Lian, Shuai Wang, Chenhao Cao, Ruhong Zhou, Di Lu, Shu-Sen Zheng, Xu-Yong Wei, Xiao Xu

Journal: J Adv Res

PubMed ID: 39547439

Doi: 10.1016/j.jare.2024.11.021

Products & Services: Protein Electrophoresis and Western

Evolutionary insights into the stereoselectivity of imine reductases based on ancestral sequence reconstruction

Authors: Xin-Xin Zhu, Wen-Qing Zheng, Zi-Wei Xia, Xin-Ru Chen, Tian Jin, Xu-Wei Ding, Fei-Fei Chen, Qi Chen, Jian-He Xu, Xu-Dong Kong, Gao-Wei Zheng

Journal: Nat Commun

PubMed ID: 39609402

Doi: 10.1038/s41467-024-54613-3

Products & Services: Plasmid DNA Preparation

Identification of FBLL1 as a neuron-specific RNA 2'-O-methyltransferase mediating neuronal differentiation

Authors: Deyu Zhang , Bo Li , Henan Xu , Jingying Li , Chao Ma , Wei Ge , Congcong Lu , and Xuetao Cao

Journal: Proc Natl Acad Sci U S A

PubMed ID: 39570315

Doi: 10.1073/pnas.2406961121

Products & Services: Protein and Antibody Isolation Custom DNA/RNA Oligos

Split-design approach enhances the therapeutic efficacy of ligand-based CAR-T cells against multiple B-cell malignancies

Authors: Shuhong Li , Licai Shi , Lijun Zhao , Qiaoru Guo , Jun Li , Ze-Lin Liu , Zhi Guo , Yu J Cao

Journal: Nat Commun

PubMed ID: 39528513

Doi: 10.1038/s41467-024-54150-z

Products & Services: Recombinant Proteins Gene Synthesis

Fused extracellular vesicles from M2 macrophages and human umbilical cord mesenchymal stem cells for the targeted regulation of macrophage pyroptosis in periprosthetic osteolysis

Authors: Qimeng Liu , Tianliang Ma , Zheyu Zhang , Jiangyu Nan , Guanzhi Liu , Yute Yang , Yihe Hu , Jie Xie

Journal: J Extracell Vesicles

PubMed ID: 39711510

Doi: 10.1002/jev2.70028

Products & Services: Protein Electrophoresis and Western

The TMEM132B-GABAA receptor complex controls alcohol actions in the brain

Authors: Guohao Wang , Shixiao Peng , Miriam Reyes Mendez , Angelo Keramidas , David Castellano , Kunwei Wu , Wenyan Han , Qingjun Tian , Lijin Dong , Yan Li , Wei Lu

Journal: Cell

PubMed ID: 39357522

Doi: 10.1016/j.cell.2024.09.006

Products & Services: Polyclonal Antibody Services

Interactions established by isoform-specific TrkB-T1 sequences govern inflammatory response and neurotoxicity in stroke

Authors: Lola Ugalde-Triviño, Gonzalo S. Tejeda, Gema M. Esteban-Ortega, Margarita Díaz-Guerra

Journal: biorxiv

Doi: doi.org/10.1101/2024.11.13.623346

Products & Services: Catalog Peptides

RAD18-catalysed formation of ubiquitination intermediate mimic of proliferating cell nuclear antigen PCNA

Authors: Liying Zhang, Zhiheng Deng, Yunxiang Du, Ziyu Xu, Tianyi Zhang, Zebin Tong, Huasong Ai, Lu-Jun Liang, Lei Liu

Journal: Bioorg Med Chem

PubMed ID: 39580855

Doi: 10.1016/j.bmc.2024.118016

Products & Services: Gene Synthesis Protein and Antibody Isolation

A high-performance protein preparation approach in a single column-free step

Authors: Yuan Huang, Yuanyuan Zhang, Xiaofeng Yang, Zhanglin Lin

Journal: Trends Biotechnol

PubMed ID: 39537535

Doi: 10.1016/j.tibtech.2024.10.008

Products & Services: Protein Electrophoresis and Western

Spatial organization of PI3K-PI(3,4,5)P3-AKT signaling by focal adhesions

Authors: Jing Wang , Zhengyang An , Zhongsheng Wu , Wei Zhou , Pengyu Sun , Piyu Wu , Song Dang , Rui Xue , Xue Bai , Yongtao Du , Rongmei Chen , Wenxu Wang , Pei Huang , Sin Man Lam , Youwei Ai , Suling Liu , Guanghou Shui , Zhe Zhang , Zheng Liu , Jianyong Huang , Xiaohong Fang , Kangmin He

Journal: Mol Cell

PubMed ID: 39488211

Doi: 10.1016/j.molcel.2024.10.010

Products & Services: Protein and Antibody Isolation

Both chebulagic acid and punicalagin inhibit respiratory syncytial virus entry via multi-targeting glycoprotein and fusion protein

Authors: Yingcai Xiong , Keyu Tao , Tao Li , Yinghui Zhou , Zhaowei Zhang , Weiying Ou , Zhao Wang , Shouchuan Wang , Yayi Hou , Peng Cao , Jianjian Ji

Journal: J Virol

PubMed ID: 39508604

Doi: 10.1128/jvi.01536-24

Products & Services: Peptide Synthesis

Engineered mRNAs with stable structures minimize double-stranded RNA formation and increase protein expression

Authors: Qianshan Qin , Huayuan Yan , Weixiang Gao , Ruyin Cao , Guopeng Liu , Xiaojing Zhang , Niangang Wang , Wenjie Zuo , Lei Yuan , Peng Gao , Qi Liu

Journal: J Mol Biol

PubMed ID: 39427983

Doi: 10.1016/J.JMB.2024.168822

Products & Services: Gene Synthesis

Interactomic exploration of LRRC8A in volume-regulated anion channels

Journal: Cell death discovery

PubMed ID: 38909013

Doi: 10.1038/s41420-024-02032-0

Products & Services: Protein Electrophoresis and Western

Engineering of Peptide Inserted Base Editors with Enhanced Accuracy and Security

Authors: Qi Chen; Yangning Sun; Jia Yao; Yingfan Lu; Ruikang Qiu; Fuling Zhou; Zixin Deng; Yuhui Sun

Journal: Small (Weinheim an der Bergstrasse, Germany)

PubMed ID: 39995348

Doi: 10.1002/smll.202411583

Enhanced HIV SOSIP Envelope yields in plants through transient co-expression of peptidyl-prolyl isomerase B and calreticulin chaperones and ER targeting

Authors: Yvonne J. Rosenberg; Xiaoming Jiang; Jonathan P. Lees; Lori A. Urban; Lingjun Mao; Markus Sack

Journal: Scientific REPORTS

PubMed ID: 35705669

Doi: 10.1038/s41598-022-14075-3

Products & Services: Catalog Antibodies

Enhanced HIV SOSIP Envelope yields in plants through transient co-expression of peptidyl-prolyl isomerase B and calreticulin chaperones and ER targeting

Authors: Yvonne J. Rosenberg; Xiaoming Jiang; Jonathan P. Lees; Lori A. Urban; Lingjun Mao; Markus Sack

Journal: Scientific REPORTS

PubMed ID: 35705669

Doi: 10.1038/s41598-022-14075-3

Products & Services: Catalog Antibodies

Self-Adjuvanting Bacteria Hydrogel for SHP1 Checkpoint Inhibition in Tumor-Draining Lymph Nodes to Enhance Cancer Immunotherapy

Authors: Xiuhua Pan, Feiyang Liu, Ruixin Kang, Zongwei Hu, Yueru Pang, Ziqi Shen, Xiawei Zhou, Jun Zhang, Qi Shen

Journal: Advanced Functional Materials

Doi: 10.1002/adfm.202409736

Products & Services: Common Tools

Zinc–Nickel Bimetallic Hydroxide Nanosheets Activate the Paraptosis–Pyroptosis Positive Feedback Cycle for Enhanced Tumor Immunotherapy

Authors: Youdong Chen 1, Yujie Lu , Huali Lei 1, Lin Liu , Xianmin Li 1, Yuqi Yang 1, Shumin Sun 1, Qiao Yu 1, Li Wang 1, Jie Wu 1 2, Jingrui Li 1, Guanghui Hou 1, Liang Cheng

Journal: ACS Nano

PubMed ID: 39404652

Doi: 10.1021/acsnano.4c10378

Products & Services: Protein and Antibody Isolation

SARS-CoV-2 N protein coordinates viral particle assembly through multiple domains

Authors: Yuewen Han 1, Haiwu Zhou 1, Cong Liu 1, Weiwei Wang 1, Yali Qin 2, Mingzhou Chen

Journal: Journal of Virology

PubMed ID: 39412257

Doi: 10.1128/jvi.01036-24

Products & Services: Plasmids for SARS-CoV-2 Detection and Research Gene Synthesis

Single-Dose Physically Cross-Linked Hyaluronic Acid and Lipid Hybrid Nanoparticles Containing Cyclic Guanosine Monophosphate-Adenosine Monophosphate Eliminate Established Tumors

Authors: Jinchao Yu , Xinyan Li , Junyao Li , Nan Sun , Peng Cheng , Jiayi Huang , Sai Li , Rui Kuai

Journal: ACS Nano

PubMed ID: 39418110

Doi: 10.1021/acsnano.4c10673

Products & Services: Recombinant Proteins

Caspase-2 is a condensate-mediated deubiquitinase in protein quality control

Authors: Yingwei Ge , Lijie Zhou, Yesheng Fu , Lijuan He, Yi Chen , Dingchang Li , Yuping Xie , Jun Yang , Haitao Wu, Hongmiao Dai , Zhiqiang Peng , Yong Zhang , Shaoqiong Yi , Bo Wu 1, Xin Zhang, Yangjun Zhang , Wantao Ying 1, Chun-Ping Cui , Cui Hua Liu , Lingqiang Zhang

Journal: Nature Cell Biology

PubMed ID: 39482354

Doi: 10.1038/s41556-024-01522-8

Products & Services: Mutagenesis Services

Structure of Plasmodium vivax N -myristoyltransferase with inhibitor IMP-1088: exploring an NMT inhibitor for antimalarial therapy

Authors: Alex Mendez; Cydni Bolling; Shane Taylor; Stanley Makumire; Bart Staker; Alexandra Reers; Brad Hammerson; Stephen J. Mayclin; Jan Abendroth; Donald D. Lorimer; Thomas E. Edwards; Edward W. Tate; Sandhya Subramanian; Andrew S. Bell; Peter J. Myler; Oluwatoyin A. Asojo; Graham Chakafana

Journal: Acta Crystallographica Section F: Structural Biology Communications

PubMed ID: 39655507

Doi: 10.1107/S2053230X24011348

Structure of Plasmodium vivax N -myristoyltransferase with inhibitor IMP-1088: exploring an NMT inhibitor for antimalarial therapy

Journal: Acta Crystallographica Section F: Structural Biology Communications

PubMed ID: 39655507

Doi: 10.1107/S2053230X24011348