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Carotenoid cleavage enzymes evolved convergently to generate the visual chromophore

Authors: Yasmeen J Solano , Michael P Everett , Kelly S Dang , Jude Abueg , Philip D Kiser

Journal: Nature Chemical Biology

PubMed ID: 38355721

Doi: 10.1038/s41589-024-01554-z

Products & Services: Plasmid DNA Preparation

Unraveling the Catalytic Mechanism of Taxadiene-5α-hydroxylase from Crystallography and Computational Analyses

Authors: Xitong Song, Qian Wang, Xiaoxi Zhu, Wenhan Fang, Xiaonan Liu, Chao Shi, Zhenzhan Chang, Huifeng Jiang, and Binju Wang

Journal: ACS Catal

Doi: doi.org/10.1021/acscatal.3c05807

Products & Services: Gene Synthesis

Neuroprotective effects of annexin A1 tripeptide in rats with sepsis-associated encephalopathy

Authors: Qiao Cui, Nannan Qin, Yonghan Zhang, Yanmei Miao, Leiyu Xie, Xinglong Ma, Zhiquan Zhang, Peng Xie

Journal: Biotechnol Appl Biochem

PubMed ID: 38409880

Doi: 10.1002/bab.2569

Products & Services: Peptide Synthesis

Visualizing the impact of disease-associated mutations on G protein-nucleotide interactions

Authors: Kara Anazia, Lucien Koenekoop, Guillaume Ferré, Enzo Petracco, Hugo Gutiérrez-de-Teran, Matthew T Eddy

Journal: biorxiv

PubMed ID: 38352316

Doi: 10.1101/2024.01.30.578006

Products & Services: PCR Cloning and Subcloning

Stalled translation by mitochondrial stress upregulates a CNOT4-ZNF598 ribosomal quality control pathway important for tissue homeostasis

Authors: Ji Geng, Shuangxi Li, Yu Li, Zhihao Wu, Sunil Bhurtel, Suman Rimal, Danish Khan, Rani Ohja, Onn Brandman, Bingwei Lu

Journal: Nat Commun

PubMed ID: 38388640

Doi: 10.1038/s41467-024-45525-3

Products & Services: Molecular Biology Reagents

Activation of CBASS Cap5 endonuclease immune effector by cyclic nucleotides

Authors: Olga Rechkoblit, Daniela Sciaky, Dale F Kreitler, Angeliki Buku, Jithesh Kottur, Aneel K Aggarwal

Journal: Nat Struct Mol Biol

PubMed ID: 38321146

Doi: 10.1038/s41594-024-01220-x

Products & Services: Molecular Biology Reagents

The exposure to glyphosate on the integrity of intestinal epithelial tight junctions of chicks

Authors: Mohamed A Fathi, Dan Shen, Lu Luo, Yansen Li, Shaaban S Elnesr, Chunmei Li

Journal: J Environ Sci Health B

PubMed ID: 38400726

Doi: 10.1080/03601234.2024.2319006

Products & Services: Gene Synthesis

Gene-edited triple mutant Medicago plants do not flower

Authors: Axel Poulet, Min Zhao, Yongyan Peng, FangFei Tham, Mauren Jaudal, Lulu Zhang, Josien C van Wolfswinkel, Joanna Putterill

Journal: Front Plant Sci

PubMed ID: 38469328

Doi: 10.3389/fpls.2024.1357924

Products & Services: Molecular Biology Reagents

Effects of polyphenol and gelatin types on the physicochemical properties and emulsion stabilization of polyphenol-crosslinked gelatin conjugates

Authors: Wenjuan Wu, Cuiping Shi, Ye Zi, Huan Gong, Lijia Chen, Guangyi Kan, Xichang Wang, Jian Zhong

Journal: Food Chem X

PubMed ID: 38440057

Doi: 10.1016/j.fochx.2024.101250

Products & Services: Proteins, Expression, Isolation and Analysis

A Modified Tridecapeptide Probe for Imaging Cell Junction

Authors: Jingrui Li, Yuhan Wu, Chunyu Liu, Shu Zhang, Xin Su, Songbo Xie, Fengtang Yang

Journal: Molecules

PubMed ID: 38474514

Doi: 10.3390/molecules29051003

Products & Services: Catalog Peptides

Structure of the WYL-domain containing transcription activator, DriD, in complex with ssDNA effector and DNA target site

Authors: Maria A Schumacher, Emily Cannistraci, Raul Salinas, Devin Lloyd, Ella Messner, Kevin Gozzi

Journal: Nucleic Acids Res

PubMed ID: 38142455

Doi: 10.1093/nar/gkad1198

Products & Services: Mutant Libraries

A Composite Biomarker Signature of Type 1 Diabetes Risk Identified via Augmentation of Parallel Multi-Omics Data from a Small Cohort

Authors: Oscar Alcazar, Sung-Ting Chuang, Gang Ren, Mitsunori Ogihara, Bobbie-Jo M Webb-Robertson, Ernesto S Nakayasu, Peter Buchwald, Midhat H Abdulreda

Journal: biorxiv

PubMed ID: 38405796

Doi: 10.1101/2024.02.09.579673

Products & Services: Proteins, Expression, Isolation and Analysis

Metabolic engineering of Synechocystis sp PCC 6803 for the improved production of phenylpropanoids

Authors: Kateryna Kukil, Pia Lindberg

Journal: Microb Cell Fact

PubMed ID: 38369470

Doi: 10.1186/s12934-024-02330-3

Products & Services: Codon Optimization

Searching for Frataxin Function: Exploring the Analogy with Nqo15, the Frataxin-like Protein of Respiratory Complex I from

Authors: Davide Doni, Eva Cavallari, Martin Ezequiel Noguera, Hernan Gustavo Gentili, Federica Cavion, Gustavo Parisi, Maria Silvina Fornasari, Geppo Sartori, Javier Santos, Massimo Bellanda, Donatella Carbonera, Paola Costantini, Marco Bortolus

Journal: Int J Mol Sci

PubMed ID: 38339189

Doi: 10.3390/ijms25031912

Products & Services: Molecular Biology Reagents

FGF18 alleviates sepsis-induced acute lung injury by inhibiting the NF-κB pathway

Authors: Zhenyu Hu, Jindan Dai, Tianpeng Xu, Hui Chen, Guoxiu Shen, Jie Zhou, Hongfang Ma, Yang Wang, Litai Jin

Journal: Respir Res

PubMed ID: 38419044

Doi: 10.1186/s12931-024-02733-1

Products & Services: ORF cDNA Clones/MolecularCloud

EHBP1 Is Critically Involved in the Dendritic Arbor Formation and Is Coupled to Factors Promoting Actin Filament Formation

Authors: Yuanyuan Ji, Maryam Izadi-Seitz, Annemarie Landmann, Lukas Schwintzer, Britta Qualmann, Michael M Kessels

Journal: J Neurosci

PubMed ID: 38129132

Doi: 10.1523/JNEUROSCI.0236-23.2023

Products & Services: Recombinant Proteins

Porcine circovirus type 2 infection promotes the SUMOylation of nucleophosmin-1 to facilitate the viral circular single-stranded DNA replication

Authors: Qian Du, Lei Zhu, Jianhui Zhong, Xueqi Wei, Qi Zhang, Tengfei Shi, Cong Han, Xinhuan Yin, Xingqi Chen, Dewen Tong, Yong Huang

Journal: PLoS Pathog

PubMed ID: 38394330

Doi: 10.1371/journal.ppat.1012014

Products & Services: Catalog Antibody

Determinants of viscoelasticity and flow activation energy in biomolecular condensates

Authors: Ibraheem Alshareedah , Anurag Singh , Sean Yang , Vysakh Ramachandran , Alexander Quinn , Davit A Potoyan , Priya R Banerjee

Journal: SCIENCE ADVANCES

PubMed ID: 38363841

Doi: 10.1126/sciadv.adi6539

Products & Services: Peptide Synthesis

Covalent bicyclization of protein complexes yields durable quaternary structures

Authors: George H Hutchins, Sebastian Kiehstaller, Pascal Poc, Abigail H Lewis, Jisun Oh, Raya Sadighi, Nicholas M Pearce, Mohamed Ibrahim, Ivana Drienovská, Anouk M Rijs, Saskia Neubacher, Sven Hennig, Tom N Grossmann

Journal: Chem

PubMed ID: 38344167

Doi: 10.1016/j.chempr.2023.10.003

Products & Services: Proteins, Expression, Isolation and Analysis

Seed-specific expression of porcine verotoxigenic Escherichia coli antigens in tobacco plants as a potential model of edible vaccines

Authors: Serena Reggi, Matteo Dell'Anno, Antonella Baldi, Luciana Rossi

Journal: Vet Res Commun

PubMed ID: 38319502

Doi: 10.1007/s11259-024-10318-y

Products & Services: Gene Synthesis

Designed modular protein hydrogels for biofabrication

Authors: Dalia Dranseike, Yusuke Ota, Thomas G W Edwardson, Elia A Guzzi, Mao Hori, Zrinka Raguz Nakic, Dhananjay V Deshmukh, Mikail D Levasseur, Kevin Mattli, Christina M Tringides, Jiangtao Zhou, Donald Hilvert, Christin Peters, Mark W Tibbitt

Journal: Acta Biomater

PubMed ID: 38382830

Doi: 10.1016/j.actbio.2024.02.019

Products & Services: Proteins, Expression, Isolation and Analysis

Epigenetic disruption of histone deacetylase-2 accelerated apoptotic signaling and retarded malignancy in gastric cells

Authors: Sayedeh Azimeh Hosseini, Mahdi Ghatrehsamani, Hajar Yaghoobi, Fatemeh Elahian, Seyed Abbas Mirzaei

Journal: Epigenomics

PubMed ID: 38356395

Doi: 10.2217/epi-2023-0350

A mRNA Vaccine for Crimean-Congo Hemorrhagic Fever Virus Expressing Non-Fusion GnGc Using NSm Linker Elicits Unexpected Immune Responses in Mice

Authors: Tong Chen, Zhe Ding, Xuejie Li, Yingwen Li, Jiaming Lan, Gary Wong

Journal: Viruses

PubMed ID: 38543744

Doi: 10.3390/v16030378

Products & Services: Molecular Biology Reagents

Differential functional consequences of GRIN2A mutations associated with schizophrenia and neurodevelopmental disorders

Authors: Nate Shepard, David Baez-Nieto, Sumaiya Iqbal, Erkin Kurganov, Nikita Budnik, Arthur J Campbell, Jen Q Pan, Morgan Sheng, Zohreh Farsi

Journal: Sci Rep

PubMed ID: 38307912

Doi: 10.1038/s41598-024-53102-3

Products & Services: Mutagenesis Services

CircUSP1 as a novel marker promotes gastric cancer progression via stabilizing HuR to upregulate USP1 and Vimentin

Authors: Rong Li, Junyi Wang, Zhenfan Xie, Xinyu Tian, Jie Hou, Dongli Wang, Hui Qian, Han Shen, Wenrong Xu

Journal: Oncogene

PubMed ID: 38366146

Doi: 10.1038/s41388-024-02968-8

Products & Services: Molecular Biology Reagents

PeptiVAX: A new adaptable peptides-delivery platform for development of CTL-based, SARS-CoV-2 vaccines

Authors: Sara Feola, Jacopo Chiaro, Manlio Fusciello, Salvatore Russo, Iivari Kleino, Leena Ylösmäki, Eliisa Kekäläinen, Johanna Hästbacka, Pirkka T Pekkarinen, Erkko Ylösmäki, Stefania Capone, Antonella Folgori, Angelo Raggioli, Carolina Boni, Camilla Tiezzi, Andrea Vecchi, Monica Gelzo, Hassen Kared, Alessandra Nardin, Michael Fehlings, Veronique Barban, Petra Ahokas, Tapani Viitala, Giuseppe Castaldo, Lucio Pastore, Paul Porter, Sari Pesonen, Vincenzo Cerullo

Journal: Int J Biol Macromol

PubMed ID: 38331062

Doi: 10.1016/j.ijbiomac.2024.129926

Products & Services: Catalog Peptides

Photoactivatable CRISPR/Cas12a Sensors for Biomarkers Imaging and Point-of-Care Diagnostics

Authors: Qing-Nan Li, Dong-Xia Wang, Dan-Ye Chen, Jia-Ao Lyu, Ya-Xin Wang, Shun-Li Wu, Hong-Xin Jiang, De-Ming Kong

Journal: Anal Chem

PubMed ID: 38305871

Doi: 10.1021/acs.analchem.3c05497

Products & Services: Custom DNA/RNA Oligos

Role of aminopeptidase N-like in the acquisition of begomoviruses by Bemisia tabaci, the whitefly vector

Authors: Yun-Yun Fan, Yao Chi, Na Chen, Wilmer J Cuellar, Xiao-Wei Wang

Journal: Insect Sci

PubMed ID: 38369384

Doi: 10.1111/1744-7917.13336

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In vitro evolution of diagnostic antibodies targeting native antigens in plasma by sandwich flow cytometry

Authors: Mingxia Liang, Fanlei Ran, Li Li, Haiying Hang, Lili An

Journal: Biotechnol J

PubMed ID: 38403438

Doi: 10.1002/biot.202300492

Products & Services: Molecular Biology Reagents

Lianhua Qingke Preserves Mucociliary Clearance in Rat with Acute Exacerbation of Chronic Obstructive Pulmonary Disease by Maintaining Ciliated Cells Proportion and Protecting Structural Integrity and Beat Function of Cilia

Authors: Xiaoqi Wang, Yuanjie Hao, Yujie Yin, Yunlong Hou, Ningxin Han, Yi Liu, Zhen Li, Yaru Wei, Kun Ma, Jiaojiao Gu, Yan Ma, Hui Qi, Zhenhua Jia

Journal: Int J Chron Obstruct Pulmon Dis

PubMed ID: 38343495

Doi: 10.2147/COPD.S436323

Products & Services: Proteins, Expression, Isolation and Analysis

A SARS-CoV-2 RBD vaccine fused to the chemokine MIP-3α elicits sustained murine antibody responses over 12 months and enhanced lung T-cell responses

Authors: James Tristan Gordy, Yinan Hui, Courtney Schill, Tianyin Wang, Fengyixin Chen, Kaitlyn Fessler, Jacob Meza, Yangchen Li, Alannah D Taylor, Rowan E Bates, Petros C Karakousis, Andrew Pekosz, Jaiprasath Sachithanandham, Maggie Li, Styliani Karanika, Richard B Markham

Journal: Front Immunol

PubMed ID: 38370404

Doi: 10.3389/fimmu.2024.1292059

Products & Services: Molecular Biology Reagents

SPOP point mutations regulate substrate preference and affect its function

Authors: Yanran Deng, Wenhao Ding, Kaize Ma, Meixiao Zhan, Li Sun, Zizhang Zhou, Ligong Lu

Journal: Cell Death Dis

PubMed ID: 38409107

Doi: 10.1038/s41419-024-06565-1

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Efficient bio-remediation of multiple aromatic hydrocarbons using different types of thermotolerant, ring-cleaving dioxygenases derived from Aeribacillus pallidus HB-1

Authors: Mingchang Li, Lu Cao, Dakun Liu, Tianqi Su, Wei Cheng, Guoqiang Li, Ting Ma

Journal: Bioresour Technol

PubMed ID: 38387841

Doi: 10.1016/j.biortech.2024.130472

Products & Services: Molecular Biology Reagents

Cell-Penetrating and Enzyme-Responsive Peptides for Targeted Cancer Therapy: Role of Arginine Residue Length on Cell Penetration and In Vivo Systemic Toxicity

Authors: Behnaz Ghaemi, Swati Tanwar, Aruna Singh, Dian R Arifin, Michael T McMahon, Ishan Barman, Jeff W M Bulte

Journal: ACS Appl Mater Interfaces

PubMed ID: 38385360

Doi: 10.1021/acsami.3c14908

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Stromal interaction molecule 1/microtubule-associated protein 1A/1B-light chain 3B complex induces metastasis of hepatocellular carcinoma by promoting autophagy

Authors: Jingchun Wang, Qichao Xie, Lei Wu, Yu Zhou, Yanquan Xu, Yu Chen, Jiangang Zhang, Ran Ren, Shiming Yang, Yongsheng Li, Huakan Zhao

Journal: MedComm (2020)

PubMed ID: 38344399

Doi: 10.1002/mco2.482

Products & Services: Molecular Biology Reagents

A bioluminescent and homogeneous assay for monitoring GPCR-mediated cAMP modulation and PDE activity

Authors: Dareen Mikheil, Matthew A Larsen, Kevin Hsiao, Nathan H Murray, Tim Ugo, Hui Wang, Said A Goueli

Journal: Sci Rep

PubMed ID: 38396287

Doi: 10.1038/s41598-024-55038-0

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Gonococcal OMV-delivered PorB induces epithelial cell mitophagy

Authors: Shuai Gao, Lingyu Gao, Dailin Yuan, Xu'ai Lin, Stijn van der Veen

Journal: Nat Commun

PubMed ID: 38396029

Doi: 10.1038/s41467-024-45961-1

Products & Services: DNA Sequencing

Shrimp injection with dsRNA targeting the microsporidian EHP polar tube protein reduces internal and external parasite amplification

Authors: Satika Yuanlae, Tharinthon Prasartset, Onrapak Reamtong, Natthinee Munkongwongsiri, Muthita Panphloi, Thanchanok Preechakul, Rungkarn Suebsing, Siripong Thitamadee, Anuphap Prachumwat, Ornchuma Itsathitphaisarn, Suparat Taengchaiyaphum, Chanadda Kasamechotchung

Journal: Sci Rep

PubMed ID: 38413745

Doi: 10.1038/s41598-024-55400-2

Products & Services: Molecular Biology Reagents

Rapid Decline of SARS-CoV-2 Viral Load in Single vs Double-Dose (Short-Interval <6 Weeks) ChAdOx nCoV-19 Vaccinated Health-Care Workers

Authors: Arnab Ghosh, Poonam Kanta, Manisha Ramola, Ritin Mohindra, Kapil Goyal, Roop Kishore, Vikas Suri, P V M Lakshmi, Chanderkanta Chauhan, Manisha Sharma, Partha Rakshit, Kalaiarasan Ponnusamy, Tanzin Dikid, Mini P Singh

Journal: Curr Microbiol

PubMed ID: 38353761

Doi: 10.1007/s00284-023-03603-7

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Expression of GPX4 by oncolytic vaccinia virus can significantly enhance CD8T cell function and its impact against pancreatic ductal adenocarcinoma

Authors: Wei Wei, Linqing Tian, Xiaoyan Zheng, Lei Zhong, Yuan Chen, Hui Dong, Guibing Zhang, Shibing Wang, Xiangmin Tong

Journal: Oncoimmunology

PubMed ID: 38419758

Doi: 10.1080/2162402X.2024.2322173

Products & Services: PCR Cloning and Subcloning

Advances and Challenges in SARS-CoV-2 Detection: A Review of Molecular and Serological Technologies

Authors:

Journal: Diagnostics (Basel)

PubMed ID: 38472991

Doi: 10.3390/diagnostics14050519

Products & Services: Proteins, Expression, Isolation and Analysis

Residues within the LptC transmembrane helix are critical for Escherichia coli LptB FG ATPase regulation

Authors: Nicholas P Cina, Dara W Frank, Candice S Klug

Journal: Protein Sci

PubMed ID: 38131105

Doi: 10.1002/pro.4879

Products & Services: Proteins, Expression, Isolation and Analysis

Biomimetic bacteria-derived nanoclusters enhance ferroptosis cancer immunotherapy through synergistic CRISPR-photothermo modulation

Authors: Xiuhua Pan , Jie Yang , Ruixin Kang , Jun Zhang , Zongwei Hu , Ning Yang , Zengyi Liu , Zengguang Jia , Xiawei Zhou , Qi Shen

Journal: Nano Today

Doi: 10.1016/j.nantod.2024.102213

Products & Services: CRISPR Services

Disordered regions mediate the interaction of p53 and MRE11

Authors: Sinem Usluer , Markus Galhuber , Yukti Khanna , Benjamin Bourgeois , Emil Spreitzer , Helene Michenthaler, Andreas Prokesch, Tobias Madl

Journal: Cell Research

PubMed ID: 38123020

Doi: 10.1016/j.bbamcr.2023.119654

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Bile salt hydrolase catalyses formation of amine-conjugated bile acids

Authors: Bipin Rimal, Stephanie L Collins, Ceylan E Tanes, Edson R Rocha, Megan A Granda, Sumeet Solanki, Nushrat J Hoque, Emily C Gentry, Imhoi Koo, Erin R Reilly, Fuhua Hao, Devendra Paudel, Vishal Singh 11, Tingting Yan 12, Min Soo Kim 2, Kyle Bittinger 3, Joseph P Zackular 13 14, Kristopher W Krausz 12, Dhimant Desai 15, Shantu Amin 15, James P Coleman 4, Yatrik M Shah 5, Jordan E Bisanz 2 16, Frank J Gonzalez 12, John P Vanden Heuvel 1 17, Gary D Wu 18, Babette S Zemel 3, Pieter C Dorrestein 7 8, Emily E Weinert 2 6, Andrew D Patterson 19 20 21

Journal: Nature

PubMed ID: 38326609

Doi: 10.1038/s41586-023-06990-w

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Harnessing eukaryotic retroelement proteins for transgene insertion into human safe-harbor loci

Authors: Xiaozhu Zhang, Briana Van Treeck, Connor A. Horton, Jeremy J. R. McIntyre, Sarah M. Palm, Justin L. Shumate & Kathleen Collins

Journal: Nat Biotechnol

PubMed ID: 38379101

Doi: 10.1038/s41587-024-02137-y

Products & Services: Plasmid DNA Preparation

Comprehensive Genomic Analysis Identifies a Diverse Landscape of Sideroblastic and Nonsideroblastic Iron-Related Anemias with Novel and Pathogenic Variants in an Iron-Deficient Endemic Setting

Authors: Pankaj Sharma, Prateek Bhatia, Minu Singh, Manu Jamwal, Swetha Pallavelangini, Reena Das, Pankaj Malhotra, Savita V Attri, Sarah Ducamp, Mark D Fleming, Amita Trehan

Journal: J Mol Diagn

PubMed ID: 38360212

Doi: 10.1016/j.jmoldx.2024.01.011

Products & Services: Molecular Biology Reagents

SARS-CoV-2 targets ribosomal RNA biogenesis

Authors: V Talya Yerlici, Audrey Astori, Nevraj S Kejiou, Chris A Jordan, Negin Khosraviani, Janet N Y Chan, Razqallah Hakem, Brian Raught, Alexander F Palazzo, Karim Mekhail

Journal: Cell Rep

PubMed ID: 38427561

Doi: 10.1016/j.celrep.2024.113891

Products & Services: Proteins, Expression, Isolation and Analysis

Engineering recombinant replication-competent bluetongue viruses expressing reporter genes for and non-invasive studies

Authors: Sergio Utrilla-Trigo, Luis Jiménez-Cabello, Alejandro Marín-López, Miguel Illescas-Amo, Germán Andrés, Eva Calvo-Pinilla, Gema Lorenzo, Piet A van Rijn, Javier Ortego, Aitor Nogales

Journal: Microbiol Spectr

PubMed ID: 38353566

Doi: 10.1128/spectrum.02493-23

Products & Services: Molecular Biology Reagents

Site-Directed Mutagenesis of VvCYP76F14 (Cytochrome P450) Unveils Its Potential for Selection in Wine Grape Varieties Linked to the Development of Wine Bouquet

Authors: Bin Peng, Jianguo Ran, Yiyang Li, Meiling Tang, Huilin Xiao, Shengpeng Shi, Youzheng Ning, Adeeba Dark, Jin Li, Xueqiang Guan, Zhizhong Song

Journal: J Agric Food Chem

PubMed ID: 38334101

Doi: 10.1021/acs.jafc.3c09083

Products & Services: Gene Synthesis

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