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Structural insights into RNA cleavage by PIWI Argonaute

Authors: Zhiqing Li , Qikui Xu , Jing Zhong , Yan Zhang , Tianxiang Zhang , Xiaoze Ying , Xiaoli Lu , Xiaoyi Li , Li Wan , Junchao Xue , Jing Huang , Ying Zhen , Zhao Zhang， Jianping Wu , En-Zhi Shen

Journal: Nature

PubMed ID: 39814893

Doi: 10.1038/s41586-024-08438-1

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Mouse totipotent blastomere-like cells model embryogenesis from zygotic genome activation to post implantation

Authors: Bing Peng , Qingyi Wang , Feixiang Zhang , Hui Shen , Peng Du

Journal: Cell Stem Cell

PubMed ID: 39826539

Doi: doi.org/10.1016/j.stem.2024.12.006

Products & Services: Protein Electrophoresis and Western

Ligand-Responsive Artificial Protein–Protein Communication for Field-Deployable Cell-Free Biosensing

Authors: Ke Wang , Siqian Liu , Shuqi Zhou , Aori Qileng , Dingyi Wang , Yingju Liu , Chunlai Chen , Chunyang Lei , Zhou Nie

Journal: Angew Chem Int Ed Engl

PubMed ID: 39558180

Doi: 10.1002/anie.202416671

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TMT-Based Quantitative Proteomic Profiling of Human Esophageal Cancer Cells Reveals the Potential Mechanism and Potential Therapeutic Targets Associated With Radioresistance

Authors: Aidi Gao , Chao He , Hengrui Chen , Qianlin Liu , Yin Chen , Jianying Sun , Chuanfeng Wu , Ya Pan , Sonia Rocha , Mu Wang , Jundong Zhou

Journal: Proteomics Clin Appl

PubMed ID: 39375892

Doi: 10.1002/prca.202400010

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Infiltrating peripheral monocyte TREM-1 mediates dopaminergic neuron injury in substantia nigra of Parkinson’s disease model mice

Authors: Wei Song, Zi-Ming Zhou, Le-le Zhang, Hai-Feng Shu, Jin-Ru Xia, Xia Qin, Rong Hua, Yong-Mei Zhang

Journal: Cell Death Dis

PubMed ID: 39809747

Doi: 10.1038/s41419-025-07333-5

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A high-definition spatiotemporal transcriptomic atlas of mammalian kidney development

Authors: Shan Jiang, Hao Yu, Ting Zhao, Yao Lu, Xuesong Li, Lei Gao, Jie Mi, Wenzhe Xia, Lanjun Geng, Panpan Li, Mingyue Chen, Mengyao Kang, Jiang Liu, Yuwen Ke

Journal: The Innovation

Doi: doi.org/10.1016/j.xinn.2024.100767

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Single-cycle parainfluenza virus type 5 vectors for producing recombinant proteins, including a humanized anti-V5 tag antibody

Authors: Richard E Randall , Dan Young , Maria Pisliakova , Jelena Andrejeva , Lynsey West , Luis Rossler , Volker Morath , David Hughes , Steve Goodbourn

Journal: JOURNAL OF GENERAL VIROLOGY

PubMed ID: 39786361

Doi: 10.1099/jgv.0.002061

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Increasing brain half-life of antibodies by additional binding to myelin oligodendrocyte glycoprotein, a CNS specific protein

Authors: Marie-Lynn Cuypers; Tom Jaspers; Jarne Clerckx; Simon Leekens; Christopher Cawthorne; Guy Bormans; Frederik Cleeren; Nick Geukens; Bart De Strooper; Maarten Dewilde

Journal: Fluids and barriers of the CNS

PubMed ID: 39885527

Doi: 10.1186/s12987-025-00624-1

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Biochemical characterization and discovery of inhibitors for PfSir2A: new tricks for an old enzyme

Authors: Dickson Donu, Emily Boyle, Alyson Curry, Yana Cen

Journal: RSC Chemical biology

PubMed ID: 39897407

Doi: 10.1039/d4cb00206g

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OGG1 and MUTYH repair activities promote telomeric 8-oxoguanine induced senescence in human fibroblasts

Authors: Mariarosaria De Rosa, Ryan P Barnes, Ariana C Detwiler, Prasanth R Nyalapatla, Peter Wipf, Patricia L Opresko

Journal: Nature Communications

PubMed ID: 39837827

Doi: 10.1038/s41467-024-55638-4

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Self-Cascaded Pyroptosis-STING Initiators for Catalytic Metalloimmunotherapy

Authors: Qiao Yu, Shumin Sun, Nailin Yang, Zifan Pei, Youdong Chen, Jihu Nie, Huali Lei, Li Wang, Fei Gong, Liang Cheng

Journal: Journal of the American Chemical Society

PubMed ID: 39818788

Doi: 10.1021/jacs.4c12552

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Structural insights into the mechanism of phosphate recognition and transport by XPR1

Authors: Wenhui Zhang, Yanke Chen, Zeyuan Guan, Yong Wang, Meng Tang, Zhangmeng Du, Jie Zhang, Meng Cheng, Jiaqi Zuo, Yan Liu, Qiang Wang, Yanjun Liu, Delin Zhang, Ping Yin, Ling Ma & Zhu Liu

Journal: Nature Communications

PubMed ID: 39747008

Doi: 10.1038/s41467-024-55471-9

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Complement factor H targeting antibody GT103 in refractory non-small cell lung cancer: a phase 1b dose escalation trial

Authors: Jeffrey M. Clarke, George R. Simon, Hirva Mamdani, Lin Gu, James E. Herndon II, Thomas E. Stinchcombe, Neal Ready, Jeffrey Crawford, Guru Sonpavde, Stephen Balevic, Andrew B. Nixon, Michael Campa, Elizabeth B. Gottlin, Huihua Li, Ruchi Saxena, You Wen He, Scott Antonia & Edward F. Patz Jr

Journal: Nature Communications

PubMed ID: 39747856

Doi: 10.1038/s41467-024-55092-2

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Klp2-mediated Rsp1-Mto1 colocalization inhibits microtubule-dependent microtubule assembly in fission yeast

Authors: Lingyun Nie , Wenyue Liu , Zhuobi Liang , Fan Zheng , Xing Liu , Xuebiao Yao , Shengqi Xiang , Kai Jiang , Shengnan Zheng , Chuanhai Fu

Journal: SCIENCE ADVANCES

PubMed ID: 39752482

Doi: 10.1126/sciadv.adq0670

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Large-scale multicenter study reveals anticitrullinated SR-A peptide antibody as a biomarker and exacerbator for rheumatoid arthritis

Authors: by Yang XieChaonan WeiDongdong FuWei ZhangYan DuChuncui HuangShuyan LiuRanran YaoZihao HeShenghua ZhangXu JinBin ShenLulu CaoPing WangXiangyu FangXi ZhengHongying LinXihua WeiWenhao LinMingxin BaiDanxue ZhuYingni LiYamin DingHuaqun ZhuHua YeJing HeYin SuYuan JiaHuaxiang WuYongfu WangDan XingXiaoyan QiuZhanguo LiFanlei Hu

Journal: SCIENCE ADVANCES

PubMed ID: 39752500

Doi: 10.1126/sciadv.adr8078

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Multivalent S2 subunit vaccines provide broad protection against Clade 1 sarbecoviruses in female mice

Authors: Peter J. Halfmann, Raj S. Patel, Kathryn Loeffler, Atsuhiro Yasuhara, Lee-Ann Van De Velde, Jie E. Yang, Jordan Chervin, Chloe Troxell, Min Huang, Naiying Zheng, Elizabeth R. Wright, Paul G. Thomas, Patrick C. Wilson, Yoshihiro Kawaoka & Ravi S. Kane

Journal: Nature Communications

PubMed ID: 39774966

Doi: 10.1038/s41467-025-55824-y

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Structural and bioinformatics analyses identify deoxydinucleotide-specific nucleases and their association with genomic islands in gram-positive bacteria

Authors: Sofia Mortensen, Stanislava Kuncová, Justin D Lormand, Tanner M Myers, Soo-Kyoung Kim, Vincent T Lee, Wade C Winkler, Holger Sondermann

Journal: Nucleic Acids Research

PubMed ID: 39778863

Doi: 10.1093/nar/gkae1235

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Increased SOAT2 expression in aged regulatory T cells is associated with altered cholesterol metabolism and reduced anti-tumor immunity

Authors: Mingjiong Zhang, Jiahua Cui, Haoyan Chen, Yifan Cheng, Qiaoyu Chen, Feng Zong, Xiao Lu, Lang Qin, Yu Han, Xingwang Kuai, Yuxing Zhang, Minjie Chu, Shuangshuang Wu & Jianqing Wu

Journal: Nature Communications

PubMed ID: 39805872

Doi: 10.1038/s41467-025-56002-w

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Scale-free Spatio-temporal Correlations in Conformational Fluctuations of Intrinsically Disordered Proteins

Authors: Haoyu Song, Jian Cui, Guorong Hu, Long Xiong, Yanee Wutthinitikornkit, Hai Lei, Jingyuan Li

Journal: Advanced Science

PubMed ID: 39807013

Doi: 10.1002/advs.202412989

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Recombinant expression systems for production of stabilised virus-like particles as next-generation polio vaccines

Authors: Lee Sherry, Mohammad W. Bahar, Claudine Porta, Helen Fox, Keith Grehan, Veronica Nasta, Helen M. E. Duyvesteyn, Luigi De Colibus, Johanna Marsian, Inga Murdoch, Daniel Ponndorf, Seong-Ryong Kim, Sachin Shah, Sarah Carlyle, Jessica J. Swanson, Sue Matthews, Clare Nicol, George P. Lomonossoff, Andrew J. Macadam, Elizabeth E. Fry, David I. Stuart, Nicola J. Stonehouse & David J. Rowlands

Journal: Nature Communications

PubMed ID: 39827284

Doi: 10.1038/s41467-025-56118-z

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Methylation of the chromatin modifier KMT2D by SMYD2 contributes to therapeutic response in hormone-dependent breast cancer

Authors: Ryan Blawski; Bujamin H. Vokshi; Xinyu Guo; Srushti Kittane; Mirna Sallaku; Wanlu Chen; Martina Gjyzari; Tony Cheung; Yuhan Zhang; Christopher Simpkins; Weiqiang Zhou; Amanda Kulick; Peihua Zhao; Meihan Wei; Pranavkrishna Shivashankar; Tatiana Prioleau; Pedram Razavi; Richard Koche; Vito W. Rebecca; Elisa de Stanchina; Pau Castel; Ho Man Chan; Maurizio Scaltriti; Emiliano Cocco; Hongkai Ji; Minkui Luo; Eneda Toska

Journal: Cell Reports

PubMed ID: 38700982

Doi: 10.1016/j.celrep.2024.114174

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Methylation of the chromatin modifier KMT2D by SMYD2 contributes to therapeutic response in hormone-dependent breast cancer

Journal: Cell Reports

PubMed ID: 38700982

Doi: 10.1016/j.celrep.2024.114174

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Deep mutational scanning and machine learning for the analysis of antimicrobial-peptide features driving membrane selectivity

Authors: Justin R. Randall; Luiz C. Vieira; Claus O. Wilke; Bryan W. Davies

Journal: Nature biomedical engineering

PubMed ID: 39085646

Doi: 10.1038/s41551-024-01243-1

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Deep mutational scanning and machine learning for the analysis of antimicrobial-peptide features driving membrane selectivity

Authors: Justin R. Randall; Luiz C. Vieira; Claus O. Wilke; Bryan W. Davies

Journal: Nature biomedical engineering

PubMed ID: 39085646

Doi: 10.1038/s41551-024-01243-1

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Discovering CRISPR-Cas system with self-processing pre-crRNA capability by foundation models

Authors: Wenhui Li, Xianyue Jiang, Wuke Wang, Liya Hou, Runze Cai, Yongqian Li, Qiuxi Gu, Qinchang Chen, Peixiang Ma, Jin Tang, Menghao Guo, Guohui Chuai, Xingxu Huang, Jun Zhang, Qi Liu

Journal: Nature Communications

PubMed ID: 39789054

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Probing SARS-CoV-2 membrane binding peptide via single-molecule AFM-based force spectroscopy

Authors: Qingrong Zhang, Raissa S. L. Rosa, Ankita Ray, Kimberley Durlet, Gol Mohammad Dorrazehi, Rafael C. Bernardi & David Alsteens

Journal: Nature Communications

PubMed ID: 39747000

Doi: 10.1038/s41467-024-55358-9

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MCM2-7 ring closure involves the Mcm5 C-terminus and triggers Mcm4 ATP hydrolysis

Authors: Sarah V. Faull, Marta Barbon, Audrey Mossler, Zuanning Yuan, Lin Bai, L. Maximilian Reuter, Alberto Riera, Christian Winkler, Indiana Magdalou, Matthew Peach, Huilin Li & Christian Speck

Journal: Nature Communications

PubMed ID: 39747125

Doi: 10.1038/s41467-024-55479-1

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Dietary amino acids promote glucagon-like hormone release to generate global calcium waves in adipose tissues in Drosophila

Authors: Muhammad Ahmad, Shang Wu, Shengyao Luo, Wenjia Shi, Xuan Guo, Yuansheng Cao, Norbert Perrimon & Li He

Journal: Nature Communications

PubMed ID: 39747032

Doi: 10.1038/s41467-024-55371-y

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Regulation of N-degron recognin-mediated autophagy by the SARS-CoV-2 PLpro ubiquitin deconjugase

Authors: Carlos Ayala-Torres , Jiangnan Liu , Nico P Dantuma , Maria G Masucci

Journal: Autophagy

PubMed ID: 39723606

Doi: 10.1080/15548627.2024.2442849

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Reconstitution of human DNA licensing and the structural and functional analysis of key intermediates

Authors: Jennifer N. Wells, Lucy V. Edwardes, Vera Leber, Shenaz Allyjaun, Matthew Peach, Joshua Tomkins, Antonia Kefala-Stavridi, Sarah V. Faull, Ricardo Aramayo, Carolina M. Pestana, Lepakshi Ranjha & Christian Speck

Journal: Nature Communications

PubMed ID: 39779677

Doi: 10.1038/s41467-024-55772-z

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Screening the human miRNA interactome reveals coordinated up-regulation in melanoma, adding bidirectional regulation to miRNA networks

Authors: Faezeh Jame-Chenarboo , Joseph N Reyes , Nicholas M Twells , Hoi Hei Ng , Dawn Macdonald , Eva Hernando , Lara K Mahal

Journal: SCIENCE ADVANCES

PubMed ID: 39792681

Doi: 10.1126/sciadv.adr0277

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f the human autophagy factor EPG5 and the molecular basis of its conserved mode of interaction with Atg8-family proteins

Authors: Yiu Wing Sunny Cheung , Sung-Eun Nam , Gage M J Fairlie , Karlton Scheu , Jennifer M Bui , Hannah R Shariati , Jörg Gsponer , Calvin K Yip

Journal: Autophagy

PubMed ID: 39809444

Doi: 10.1080/15548627.2024.2447213

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Engineering a membrane protein chaperone to ameliorate the proteotoxicity of mutant huntingtin

Authors: Jeonghyun Oh, Christy Catherine, Eun Seon Kim, Kwang Wook Min, Hae Chan Jeong, Hyojin Kim, Mijin Kim, Seung Hae Ahn, Nataliia Lukianenko, Min Gu Jo, Hyeon Seok Bak, Sungsu Lim, Yun Kyung Kim, Ho Min Kim, Sung Bae Lee & Hyunju Cho

Journal: Nature Communications

PubMed ID: 39824813

Doi: 10.1038/s41467-025-56030-6

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Hypoxia-tropic delivery of nanozymes targeting transferrin receptor 1 for nasopharyngeal carcinoma radiotherapy sensitization

Authors: Ruofei Zhang, Yanfang Shen, Xiaoying Zhou, Jianru Li, Hanqing Zhao, Zixia Zhang, Jun Zhao, Hongjun Jin, Shuanshuan Guo, Hui Ding, Guohui Nie, Zhe Zhang, Ying Wang, Xiyun Yan & Kelong Fan

Journal: Nature Communications

PubMed ID: 39837820

Doi: 10.1038/s41467-025-56134-z

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Coordinated conformational changes in P450 decarboxylases enable hydrocarbons production from renewable feedstocks

Authors: Wesley Cardoso Generoso, Alana Helen Santana Alvarenga, Isabelle Taira Simões, Renan Yuji Miyamoto, Ricardo Rodrigues de Melo, Ederson Paulo Xavier Guilherme, Fernanda Mandelli, Clelton Aparecido Santos, Rafaela Prata, Camila Ramos dos Santos, Felippe Mariano Colombari, Mariana Abrahão Bueno Morais, Rodrigo Pimentel Fernandes, Gabriela Felix Persinoti, Mario Tyago Murakami & Leticia Maria Zanphorlin

Journal: Nature Communications

PubMed ID: 39843428

Doi: 10.1038/s41467-025-56256-4

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Mismatch prime editing gRNA increased efficiency and reduced indels

Authors: Jidong Fei , Dongdong Zhao , Caiyi Pang , Ju Li , Siwei Li , Wentao Qiao , Juan Tan , Changhao Bi , Xueli Zhang

Journal: Nat Commun

PubMed ID: 39747083

Doi: 10.1038/s41467-024-55578-z

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Systematic functional characterization of non-coding regulatory SNPs associated with central obesity

Authors: Shan-Shan Dong, Yuan-Yuan Duan, Ren-Jie Zhu, Ying-Ying Jia, Jia-Xin Chen, Xiao-Ting Huang, Shi-Hao Tang, Ke Yu, Wei Shi, Xiao-Feng Chen, Feng Jiang, Ruo-Han Hao, Yunlong Liu, Zhongbo Liu, Yan Guo, and Tie-Lin Yang

Journal: The American Journal of Human Genetics

Doi: doi.org/10.1016/j.ajhg.2024.11.005

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Salivary elicitor disulffde isomerase from Nilaparvata lugens targets host rice UDP-glucose epimerase 2 to induce plant defenses

Authors: Jianmei Fu , Zhichang Zhao , Jichao Fang , Rui Ji

Journal: Plant Stress

Doi: doi.org/10.1016/j.stress.2025.100744

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Energy-guided accumulated mutation strategy achieves a highly efficient polyethylene terephthalate-degrading enzyme

Authors: Zhi Wang, Jiaxing Zhang, Shengping You, Rongxin Su, Wei Qi

Journal: Biochemical Engineering Journal

Doi: 10.1016/j.bej.2025.109708

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Steric confinement-induced emission probe for monitoring protein conformations in live cells

Authors: Huixia Jia; Lin Yang; Yu Yang; He Liu; Jia Liu; Chunfeng Shang; Zengru Di; Benzhao He; Ke Zhang

Journal: Communications Chemistry

PubMed ID: 41611810

Doi: 10.1038/s42004-026-01914-x

Structural dynamics of calcium and integrin-binding protein 2 (CIB2) reveal uncommon flexibility and heterogeneous calcium and magnesium loading

Authors: Gabriele Olivieri, Giuditta Dal Cortivo, Rebecca Del Conte, Serena Zanzoni, Valerio Marino, Daniele Dell'Orco, Francesca Cantini

Journal: International Journal of Biological Macromolecules

PubMed ID: 39586446

Doi: doi.org/10.1016/j.ijbiomac.2024.138003

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Interplay between the Xer recombination system and the dissemination of antibioresistance in Acinetobacter baumannii

Authors: Corentin Blanchais, Carine Pages, Manuel Campos, Kenza Boubekeur, Rachel Contarin, Mathias Orlando, Patricia Siguier, Maria-Halima Laaberki, François Cornet, Xavier Charpentier, Philippe Rousseau

Journal: Nucleic Acids Research

PubMed ID: 39777461

Doi: 10.1093/nar/gkae1255

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Biochemical and structural characterization of Rab3GAP reveals insights into Rab18 nucleotide exchange activity

Authors: Gage M. J. Fairlie, Kha M. Nguyen, Sung-Eun Nam, Alexandria L. Shaw, Matthew A. H. Parson, Hannah R. Shariati, Xinyin Wang, Meredith L. Jenkins, Michael Gong, John E. Burke & Calvin K. Yip

Journal: Nature Communications

PubMed ID: 39779760

Doi: 10.1038/s41467-025-55828-8

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Influenza A Virus H7 nanobody recognizes a conserved immunodominant epitope on hemagglutinin head and confers heterosubtypic protection

Authors: Zhao-Shan Chen, Hsiang-Chi Huang, Xiangkun Wang, Karin Schön, Yane Jia, Michael Lebens, Danica F. Besavilla, Janarthan R. Murti, Yanhong Ji, Aishe A. Sarshad, Guohua Deng, Qiyun Zhu & Davide Angeletti

Journal: Nature Communications

PubMed ID: 39788944

Doi: 10.1038/s41467-024-55193-y

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Barcoded SARS-CoV-2 viruses define the impact of duration and route of exposure on the transmission bottleneck in a hamster model

Authors: Reed Trende , Tamarand L Darling , Tianyu Gan , David Wang , Adrianus C M Boon

Journal: SCIENCE ADVANCES

PubMed ID: 39813353

Doi: 10.1126/sciadv.ads2927

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Identification of a binding site for small molecule inhibitors targeting human TRPM4

Authors: Babatunde Ekundayo, Prakash Arullampalam, Christian E. Gerber, Anne-Flore Hämmerli, Sabrina Guichard, Mey Boukenna, Daniela Ross-Kaschitza, Martin Lochner, Jean-Sebastien Rougier, Henning Stahlberg, Hugues Abriel & Dongchun Ni

Journal: Nature Communications

PubMed ID: 39828793

Doi: 10.1038/s41467-025-56131-2

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Dynamic allostery in the peptide/MHC complex enables TCR neoantigen selectivity

Authors: Jiaqi Ma, Cory M. Ayres, Chad A. Brambley, Smita S. Chandran, Tatiana J. Rosales, W. W. J. Gihan Perera, Bassant Eldaly, William T. Murray, Steven A. Corcelli, Evgenii L. Kovrigin, Christopher A. Klebanoff & Brian M. Baker

Journal: Nature Communications

PubMed ID: 39833157

Doi: 10.1038/s41467-025-56004-8

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Intestine-Decipher Engineered Capsules Protect Against Sepsis-induced Intestinal Injury via Broad-spectrum Anti-inflammation and Parthanatos Inhibition

Authors: Yan Yan, Bin Li, Qiuxia Gao, Miao Wu, Hua Ma, Jiawei Bai, Chengtai Ma, Xinyu Xie, Yuan Gong, Lingqi Xu, Xiaoxue Li, Wei Wang, Yanqiu Wu, Jiamei Wang, Huanhuan Wang, Yi Feng, Yunlong Zhang, Peiran Li, Huimin Shi, Fei Ma, Yue Jia, Han Duan, Xinting Fu, Wenying Wang, Liying Zhan, Xianjin Du, Huiting Zhou, Yuhui Liao

Journal: Advanced Science

PubMed ID: 39836501

Doi: 10.1002/advs.202412799

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Microenvironment actuated CAR T cells improve solid tumor efficacy without toxicity

Authors: Kristen C Vogt , Pedro C Silberman , Qianqian Lin , James E Han , Amy Laflin , Hendryck A Gellineau , Daniel A Heller , David A Scheinberg

Journal: SCIENCE ADVANCES

PubMed ID: 39841845

Doi: 10.1126/sciadv.ads3403

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Developing orthogonal fluorescent RNAs for photoactive dual-color imaging of RNAs in live cells

Authors: Peng Yin , Chunzheng Huang , Li Zhang , Zhenzhen Li , Caijun Zhong , Shi Kuang , Chunyang Lei , Yan Huang , Zhou Nie

Journal: Angew Chem Int Ed Engl

PubMed ID: 39801450

Doi: 10.1002/anie.202424060

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