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A novel selenium analog of HDACi-based twin drug induces apoptosis and cell cycle arrest via CDC25A to improve prostate cancer therapy

Authors: Zhiyong Shi , Miaomiao Liu , Xiaowen Zhang , Jingyang Wang , Junwei Zhang , Zeyan Peng , Li Meng , Ruijing Wang ,Yang Xu , Jie Yan , Jianlin Cui , Shan Ren , Yang Gao , Yanming Wang , Zhi Qi

Journal: Theranostics

PubMed ID: 38948069

Doi: 10.7150/thno.92119

Products & Services: Nucleic Acid Purification

Library-Assisted Evolution in Eukaryotic Cells Yield Adenine Base Editors with Enhanced Editing Specificity

Authors: Shenlin Hsiao, Shuanghong Chen, Yanhong Jiang, Qiudao Wang, Yang Yang, Yongrong Lai, Tao Zhong, Jiaoyang Liao, Yuxuan Wu

Journal: Adv Sci (Weinh)

PubMed ID: 38874509

Doi: 10.1002/advs.202309004

Products & Services: Molecular Biology Reagents

Microglia undergo sex-dimorphic transcriptional and metabolic rewiring during aging

Authors: Seokjo Kang, Emily Y Ko, Amelia E Andrews, Juliana E Shin, Karina J Nance, Pijus K Barman, Peter S Heeger, Willard M Freeman, Bérénice A Benayoun, Helen S Goodridge

Journal: J Neuroinflammation

PubMed ID: 38840206

Doi: 10.1186/s12974-024-03130-7

Products & Services: Protein Electrophoresis and Western

Discovery of RXFP2 genetic association in resistant hypertensive men and RXFP2 antagonists for the treatment of resistant hypertension

Authors: Shan-Shan Zhang, Lance Larrabee, Andrew H Chang, Sapna Desai, Lisa Sloan, Xin Wang, Yixuan Wu, Nazia Parvez, Karen Amaratunga, Allison C Hartman, Abby Whitnall, Joseph Mason, Nicholas P Barton, Audrey Y Chu, Jonathan M Davitte, Adam J Csakai, Caitlin Vestal Tibbetts, Audrey E Tolbert, Heather O'Keefe, Jessie Polanco, Joseph Foley, Casey Kmett, Jonathan Kehler, Gabriela Kozejova, Feng Wang, Andrew P Mayer, Patrick Koenig, Davide Foletti, Steven J Pitts, Christine G Schnackenberg

Journal: Sci Rep

PubMed ID: 38851835

Doi: 10.1038/s41598-024-62804-7

Products & Services: Molecular Biology Reagents

A phage nucleus-associated protein from the jumbophage Churi inhibits bacterial growth through protein translation interference

Authors: Wichanan Wannasrichan, Sucheewin Krobthong, Chase J Morgan, Emily G Armbruster, Milan Gerovac, Yodying Yingchutrakul, Patompon Wongtrakoongate, Jörg Vogel, Chanat Aonbangkhen, Poochit Nonejuie, Joe Pogliano, Vorrapon Chaikeeratisak

Journal: biorxiv

PubMed ID: 38915640

Doi: 10.1101/2024.06.15.599175

Products & Services: Molecular Biology Reagents

Structural basis for an early stage of the photosystem II repair cycle in Chlamydomonas reinhardtii

Authors: Anjie Li, Tingting You, Xiaojie Pang, Yidi Wang, Lijin Tian, Xiaobo Li & Zhenfeng Liu

Journal: Nature Communications

PubMed ID: 38890314

Doi: 10.1038/s41467-024-49532-2

Products & Services: CRISPR RNAs/Cas9 Proteins(INACTIVE)

A new anti-CRISPR gene promotes the spread of drug-resistance plasmids in Klebsiella pneumoniae

Authors: Chunyu Jiang, Chengzhi Yu, Shuyi Sun, Jiajia Lin, Mufeng Cai, Zhenquan Wei, Lingling Feng, Jianhui Li, Yan Zhang, Ke Dong ... Show moreAuthor Notes

Journal: Nucleic Acids Res

PubMed ID: 38888121

Doi: 10.1093/nar/gkae516

Products & Services: Protein and Antibody Isolation

Cleaved TMEM106B forms amyloid aggregates in central and peripheral nervous systems

Authors: Mehtap Bacioglu, Manuel Schweighauser, Derrick Gray, Sofia Lövestam, Taxiarchis Katsinelos, Annelies Quaegebeur, John van Swieten, Zane Jaunmuktane, Stephen W. Davies, Sjors H. W. Scheres, Michel Goedert, Bernardino Ghetti, and Maria Grazia Spillantini

Journal: Acta Neuropathologica

PubMed ID: 38886865

Doi: 10.1186/s40478-024-01813-z

Products & Services: Protein and Antibody Isolation

The pigeon circovirus evolution, epidemiology and interaction with the host immune system under One Loft Race rearing conditions

Authors: Tomasz Stenzel, Daria Dziewulska, Ewa Łukaszuk, Joy M Custer, Matthew D De Koch, Simona Kraberger, Arvind Varsani

Journal: Sci Rep

PubMed ID: 38877168

Doi: 10.1038/s41598-024-64587-3

Products & Services: Gene Synthesis

Improved protein splicing through viral passaging

Authors: Adam J Hume , Dylan J Deeney , John S Smetana , Jacquelyn Turcinovic , John H Connor , Marlene Belfort , Elke Mühlberger , Christopher W Lennon

Journal: MBio

PubMed ID: 38780266

Doi: 10.1128/mbio.00984-24

Products & Services: Gene Synthesis Mutagenesis Services

Mechanism and spectrum of inhibition of a 4´-cyano modified nucleotide analog against diverse RNA polymerases of prototypic respiratory RNA viruses

Authors: Calvin J Gordon, Simon M Walker, Egor P Tchesnokov, Dana Kocincova, Jared Pitts, Dustin S Siegel, Jason K Perry, Joy Y Feng, John P Bilello, Matthias Götte

Journal: J Biol Chem

PubMed ID: 38945449

Doi: 10.1016/j.jbc.2024.107514

Products & Services: Molecular Biology Reagents

Broadly Applicable Bispecific Linker Approach to Noncovalently Target Therapeutic Nanoparticles to Tumor Cells Expressing Carcinoembryonic Antigen

Authors: Ann Fernando, Amanda Sparkes, Esther I Matus, Ayushi Patel, F Stuart Foster, David Goertz, Peter Lee, Jean Gariépy

Journal: ACS Pharmacol Transl Sci

PubMed ID: 38898951

Doi: 10.1021/acsptsci.4c00140

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Unraveling the Roles of Neuropeptides in the Chemosensation of the Root-Knot Nematode

Authors: Chenmi Mo, Lei Zhang

Journal: Int J Mol Sci

PubMed ID: 38928010

Doi: 10.3390/ijms25126300

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Increased efficacy of influenza virus vaccine candidate through display of recombinant neuraminidase on virus like particles

Authors: Leticia Guzman Ruiz, Alexander M Zollner, Irene Hoxie, Elsa Arcalis, Florian Krammer, Miriam Klausberger, Alois Jungbauer, Reingard Grabherr

Journal: Front Immunol

PubMed ID: 38915410

Doi: 10.3389/fimmu.2024.1425842

Products & Services: Molecular Biology Reagents

Structural basis of TMPRSS2 zymogen activation and recognition by the HKU1 seasonal coronavirus

Authors: Ignacio Fernández, Nell Saunders, Stéphane Duquerroy, William H Bolland, Atousa Arbabian, Eduard Baquero, Catherine Blanc, Pierre Lafaye, Ahmed Haouz, Julian Buchrieser, Olivier Schwartz, Félix A Rey

Journal: Cell

PubMed ID: 38964326

Doi: 10.1016/j.cell.2024.06.007

Products & Services: Mutagenesis Services

Geospatial joint modeling of vector and parasite serology to microstratify malaria transmission

Authors: Ellen A Kearney, Punam Amratia, Su Yun Kang, Paul A Agius, Kefyalew Addis Alene, Katherine O'Flaherty, Win Han Oo, Julia C Cutts, Win Htike, Daniela Da Silva Goncalves, Zahra Razook, Alyssa E Barry, Damien Drew, Aung Thi, Kyaw Zayar Aung, Htin Kyaw Thu, Myat Mon Thein, Nyi Nyi Zaw, Wai Yan Min Htay, Aung Paing Soe, James G Beeson, Julie A Simpson, Peter W Gething, Ewan Cameron, Freya J I Fowkes

Journal: Proc Natl Acad Sci U S A

PubMed ID: 38833464

Doi: 10.1073/pnas.2320898121

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The porcine circovirus 3 humoral response: characterization of maternally derived antibodies and dynamic following experimental infection

Authors: Molly Kroeger, Gun Temeeyasen, Steven Dilberger-Lawson, Eric Nelson, Ronaldo Magtoto, Luis Gimenez-Lirola, Pablo Piñeyro

Journal: Microbiol Spectr

PubMed ID: 38916319

Doi: 10.1128/spectrum.00870-24

Products & Services: Molecular Biology Reagents

Trichostatin A Promotes Cytotoxicity of Cisplatin, as Evidenced by Enhanced Apoptosis/Cell Death Markers

Authors: Yang Zhou, Qun Luo, Fangang Zeng, Xingkai Liu, Juanjuan Han, Liangzhen Gu, Xiao Tian, Yanyan Zhang, Yao Zhao, Fuyi Wang

Journal: Molecules

PubMed ID: 38893499

Doi: 10.3390/molecules29112623

Products & Services: Protein Electrophoresis and Western

Drosophila immune cells transport oxygen through PPO2 protein phase transition

Authors: Mingyu Shin, Eunji Chang, Daewon Lee, Nayun Kim, Bumsik Cho, Nuri Cha, Ferdinand Koranteng, Ji-Joon Song, Jiwon Shim

Journal: Nature

PubMed ID: 38926577

Doi: 10.1038/s41586-024-07583-x

Products & Services: Protein and Antibody Isolation

High-yield porphyrin production through metabolic engineering and biocatalysis

Authors: Haihong Chen, Yaohong Wang, Weishan Wang, Ting Cao, Lu Zhang, Zhengduo Wang, Xuran Chi, Tong Shi, Huangwei Wang, Xinwei He, Mindong Liang, Mengxue Yang, Wenyi Jiang, Dongyuan Lv, Jiaming Yu, Guoliang Zhu, Yongtao Xie, Bei Gao, Xinye Wang, Xueting Liu, Youyuan Li, Liming Ouyang, Jingyu Zhang, Huimin Liu, Zilong Li, Yaojun Tong, Xuekui Xia, Gao-Yi Tan, Lixin Zhang

Journal: Nat Biotechnol

PubMed ID: 38839873

Doi: 10.1038/s41587-024-02267-3

Products & Services: Protein and Antibody Isolation

Evaluation in mice of cell-free produced CT584 as a Chlamydia vaccine antigen

Authors: Steven Hoang-Phou, Sukumar Pal, Anatoli Slepenkin, Abisola Abisoye-Ogunniyun, Yuliang Zhang, Sean F Gilmore, Megan Shelby, Feliza Bourguet, Mariam Mohagheghi, Aleksandr Noy, Amy Rasley, Luis M de la Maza, Matthew A Coleman

Journal: biorxiv

PubMed ID: 38895407

Doi: 10.1101/2024.06.04.597210

Products & Services: Gene Synthesis

Deciphering Structural Traits for Thermal and Kinetic Stability Across Protein Family Evolution through Ancestral Sequence Reconstruction

Authors: Pablo A Cea, Myriam Pérez, Sixto M Herrera, Sebastián M Muñoz, Nicolás Fuentes-Ugarte, José Coche-Miranda, Pablo Maturana, Victoria Guixé, Victor Castro-Fernandez

Journal: Mol Biol Evol

PubMed ID: 38913681

Doi: 10.1093/molbev/msae127

Products & Services: DNA Sequencing

Absolute quantification of viral proteins from pseudotyped VSV-GP using UPLC-MRM

Authors: Rajeswari Basu, Richard Dambra, Di Jiang, Sophia A Schätzlein, Shu Njiyang, Joseph Ashour, Abhilash I Chiramel, Adam Vigil, Vladimir V Papov

Journal: Microbiol Spectr

PubMed ID: 38916347

Doi: 10.1128/spectrum.03651-23

Products & Services: Catalog Peptides

Ethnopharmacological study on Adenosma buchneroides Bonati inhibiting inflammation via the regulation of TLR4/MyD88/NF-κB signaling pathway

Authors: Yuru Shi, Xiaoqian Zhang, Shengji Pei, Yuhua Wang

Journal: Nat Prod Bioprospect

PubMed ID: 38833115

Doi: 10.1007/s13659-024-00458-8

Products & Services: Protein and Antibody Isolation

Prostaglandin F2 Receptor Negative Regulator (PTGFRN) Expression Correlates With a Metastatic-like Phenotype in Epidermoid Carcinoma, Pediatric Medulloblastoma, and Mesothelioma

Authors: Jorge Marquez, Jianping Dong, Jun Hayashi, Ginette Serrero

Journal: J Cell Biochem

PubMed ID: 38924562

Doi: 10.1002/jcb.30616

Products & Services: Protein and Antibody Isolation

Cathepsins L and B target HIF1α for oxygen-independent proteolytic cleavage

Authors: Sarah Stuart, Daniel Tarade, Michael Ohh

Journal: Sci Rep

PubMed ID: 38926538

Doi: 10.1038/s41598-024-65537-9

Products & Services: Custom Vector Construction

Functional surface expression of immunoglobulin cleavage systems in a candidate Mycoplasma vaccine chassis

Authors: Sergi Torres-Puig, Silvia Crespo-Pomar, Hatice Akarsu, Thatcha Yimthin, Valentina Cippà, Thomas Démoulins, Horst Posthaus, Nicolas Ruggli, Peter Kuhnert, Fabien Labroussaa, Jörg Jores

Journal: Commun Biol

PubMed ID: 38942984

Doi: 10.1038/s42003-024-06497-8

Products & Services: Gene Synthesis

A chimeric membrane enzyme and an engineered whole-cell biocatalyst for efficient 1-alkene production

Authors: Tabish Iqbal, Subhashini Murugan, Debasis Das

Journal: Sci Adv

PubMed ID: 38924395

Doi: 10.1126/sciadv.adl2492

Products & Services: Protein and Antibody Isolation

A Plasmodium apicoplast-targeted unique exonuclease/FEN exhibits interspecies functional differences attributable to an insertion that alters DNA-binding

Authors: Tribeni Chatterjee, Anupama Tiwari, Ritika Gupta, Himadri Shukla, Aastha Varshney, Satish Mishra, Saman Habib

Journal: Nucleic Acids Res

PubMed ID: 38888125

Doi: 10.1093/nar/gkae512

Products & Services: Gene Synthesis

Optimization of dilution rate and mixed carbon feed for continuous production of recombinant plant sucrose:sucrose 1-fructosyltransferase in Komagataella phaffii

Authors: Avijeet S Jaswal, Ravikrishnan Elangovan, Saroj Mishra

Journal: Bioprocess Biosyst Eng

PubMed ID: 38904715

Doi: 10.1007/s00449-024-03045-w

Products & Services: PCR Cloning and Subcloning

CoHIT: a one-pot ultrasensitive ERA-CRISPR system for detecting multiple same-site indels

Authors: Yin Liu, Xinyi Liu, Dongyi Wei, Lu Dang, Xiaoran Xu, Shisheng Huang, Liwen Li, Sanyun Wu, Jinxian Wu, Xiaoyan Liu, Wenjun Sun, Wanyu Tao, Yongchang Wei, Xingxu Huang, Kui Li, Xinjie Wang, Fuling Zhou

Journal: Nat Commun

PubMed ID: 38866774

Doi: 10.1038/s41467-024-49414-7

Products & Services: Gene Synthesis

Distant relatives of a eukaryotic cell-specific toxin family evolved a complement-like mechanism to kill bacteria

Authors: Hunter L Abrahamsen, Tristan C Sanford, Casie E Collamore, Bronte A Johnstone, Michael J Coyne, Leonor García-Bayona, Michelle P Christie, Jordan C Evans, Allison J Farrand, Katia Flores, Craig J Morton, Michael W Parker, Laurie E Comstock, Rodney K Tweten

Journal: Nat Commun

PubMed ID: 38866748

Doi: 10.1038/s41467-024-49103-5

Products & Services: Recombinant Proteins

GPRC5A promotes gallbladder cancer metastasis by upregulating TNS4 via the JAK2-STAT3 pathway

Authors: Jiahua Yang, Xuechuan Li, Shili Chen, Guoqiang Li, Peng Pu, Yang Yang, Wenguang Wu, Yajun Geng, Yingbin Liu

Journal: Cancer Lett

PubMed ID: 38942137

Doi: 10.1016/j.canlet.2024.217067

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SepM mutation in Streptococcus mutans clinical isolates and related function analysis

Authors: Shanshan Liu, Yidan Shao, Zhenzhen Zhang, Wen Xu, Yudong Liu, Kai Zhang, Li Xu, Qingwei Zheng, Yu Sun

Journal: BMC Oral Health

PubMed ID: 38918777

Doi: 10.1186/s12903-024-04436-x

Products & Services: Gene Synthesis

OsNLP3 enhances grain weight and reduces grain chalkiness in rice

Authors: Liang-Qi Sun, Yu Bai, Jie Wu, Shi-Jun Fan, Si-Yan Chen, Zheng-Yi Zhang, Jin-Qiu Xia, Shi-Mei Wang, Yu-Ping Wang, Peng Qin, Shi-Gui Li, Ping Xu, Zhong Zhao, Cheng-Bin Xiang, Zi-Sheng Zhang

Journal: Plant Commun

PubMed ID: 38853433

Doi: 10.1016/j.xplc.2024.100999

Products & Services: Recombinant Proteins

M tuberculosis PrrA binds the dosR promoter and regulates mycobacterial adaptation to hypoxia

Authors: Yannik A Haller, Jiapei Jiang, Zijian Wan, Alexia Childress, Shaopeng Wang, Shelley E Haydel

Journal: Tuberculosis (Edinb)

PubMed ID: 38885567

Doi: 10.1016/j.tube.2024.102531

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The Gene Network That Regulates Head Organizer Activity in Is Differentially Regulated in Epidermis and Gastrodermis

Authors: Laura Iglesias Ollé, Chrystelle Perruchoud, Paul Gerald Layague Sanchez, Matthias Christian Vogg, Brigitte Galliot

Journal: Biomedicines

PubMed ID: 38927481

Doi: 10.3390/biomedicines12061274

Products & Services: DNA Sequencing

Immuno-Microbial Signature of Vaccine-Induced Immunity against SARS-CoV-2

Authors: Lesley Umeda, Amada Torres, Braden P Kunihiro, Noelle C Rubas, Riley K Wells, Krit Phankitnirundorn, Rafael Peres, Ruben Juarez, Alika K Maunakea

Journal: Vaccines (Basel)

PubMed ID: 38932366

Doi: 10.3390/vaccines12060637

Products & Services: Gene Synthesis

An optimized and robust workflow for quantifying the canonical histone ubiquitination marks H2AK119ub and H2BK120ub by LC-MS/MS

Authors: Mariana Lopes, Peder J Lund, Benjamin A Garcia

Journal: biorxiv

PubMed ID: 38915586

Doi: 10.1101/2024.06.11.596744

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Identification of a human type XVII collagen fragment with high capacity for maintaining skin health

Authors: Xinglong Wang, Shuyao Yu, Ruoxi Sun, Kangjie Xu, Kun Wang, Ruiyan Wang, Junli Zhang, Wenwen Tao, Shangyang Yu, Kai Linghu, Xinyi Zhao, Jingwen Zhou

Journal: Synth Syst Biotechnol

PubMed ID: 38911060

Doi: 10.1016/j.synbio.2024.06.001

Products & Services: Gene Synthesis

A novel BSL-2 Lassa virus reverse genetics system modelling the complete viral life cycle

Authors: Xiaoyou Hu, Xu Bai, Fangling Tian, Yifan Xing, Yi Shi, Yimin Tong, Jin Zhong

Journal: Emerg Microbes Infect

PubMed ID: 38747061

Doi: 10.1080/22221751.2024.2356149

Distance tuneable integral membrane protein containing floating bilayers directed self-assembly

Authors: Stephen C L Hall, David J Hardy, Éilís C Bragginton, Hannah Johnston, Tudor Onose, Rachel Holyfield, Pooja Sridhar, Timothy J Knowles, Luke A Clifton

Journal: Nanoscale

PubMed ID: 38940744

Doi: 10.1039/d3nr04622b

Products & Services: Protein and Antibody Isolation

Metabolic Engineering of for Production of Canthaxanthin, Zeaxanthin, and Astaxanthin

Authors: Peerada Promdonkoy, Akaraphol Watcharawipas, Suriyaporn Bubphasawan, Kitisak Sansatchanon, Nattida Suwanakitti, Kanokarn Kocharin, Weerawat Runguphan

Journal: J Fungi (Basel)

PubMed ID: 38921419

Doi: 10.3390/jof10060433

Products & Services: Codon Optimization

Single missense mutations in Vi capsule synthesis genes confer hypervirulence to Salmonella Typhi

Authors: Gi Young Lee, Jeongmin Song

Journal: Nat Commun

PubMed ID: 38898034

Doi: 10.1038/s41467-024-49590-6

Products & Services: Recombinant Proteins

IMT030122, A novel engineered EpCAM/CD3/4-1BB tri-specific antibody, enhances T-cell recruitment and demonstrates anti-tumor activity in mouse models of colorectal cancer

Authors: Jianbo Shen, Niliang Qian, Guili Xu, Xiaoqian Dou, Ying An, Cuima Yang, Yujie Liu, Yunhui Liu, Xiujie Pan, Jingjing Wang, Guijun Bai, Hao Chen, Xiaolin Zhu, Xin Gao, Guoxiong Zhou, Qinzhi Xu

Journal: Int Immunopharmacol

PubMed ID: 38878486

Doi: 10.1016/j.intimp.2024.112424

Products & Services: Protein and Antibody Isolation

Monoterpene-chalcone conjugates and diarylheptanoids isolated from the seeds of Alpinia katsumadai Hayata with cytotoxic activity

Authors: Hua-Lin You, Bo Zhou, Meng-Jia Guo, Xin-Man Zhao, Xiao-Long Li, Xiang-Chun Shen, Nen-Ling Zhang

Journal: Phytochemistry

PubMed ID: 38945281

Doi: 10.1016/j.phytochem.2024.114197

Products & Services: PCR Cloning and Subcloning

Plasmodium vivax serological exposure markers: PvMSP1-42-induced humoral and memory B-cell response generates long-lived antibodies

Authors: Feng Lu, Jiahui Xu, Yaobao Liu, Zhenyu Ren, Junhu Chen, Weijuan Gong, Yi Yin, Yinyue Li, Li Qian, Xinlong He, Xiu Han, Zhijie Lin, Jingyuan Lu, Wenwen Zhang, Jiali Liu, Didier Menard, Eun-Taek Han, Jun Cao

Journal: PLoS Pathog

PubMed ID: 38941356

Doi: 10.1371/journal.ppat.1012334

Products & Services: Protein and Antibody Isolation

A 14-amino acid cationic peptide Bolespleenin from the marine fish mudskipper Boleophthalmus pectinirostris exhibiting potent antimicrobial activity and therapeutic potential

Authors: Yuqi Bai, Weibin Zhang, Wenbin Zheng, Xin-Zhan Meng, Yingyi Duan, Chang Zhang, Fangyi Chen, Ke-Jian Wang

Journal: Biochem Pharmacol

PubMed ID: 38852647

Doi: 10.1016/j.bcp.2024.116344

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Adeno-associated viral delivery of Env-specific antibodies prevents SIV rebound after discontinuing antiretroviral therapy

Authors: Vadim A Klenchin, Natasha M Clark, Nida K Keles, Saverio Capuano, Rosemarie Mason, Guangping Gao, Aimee Broman, Emek Kose, Taina T Immonen, Christine M Fennessey, Brandon F Keele, Jeffrey D Lifson, Mario Roederer, Matthew R Gardner, David T Evans

Journal: biorxiv

PubMed ID: 38895320

Doi: 10.1101/2024.05.30.593694

Products & Services: Codon Optimization

The role of MASP1 in the complement system and expression characteristics in response to GCRV infection in grass carp

Authors: Yuling Wei, Zhao Lv, Tiaoyi Xiao, Zongjun Du

Journal: Fish Shellfish Immunol

PubMed ID: 38901682

Doi: 10.1016/j.fsi.2024.109712

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