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Quantification of SARS-CoV-2 monoclonal IgG mass fraction by isotope dilution mass spectrometry

Authors: G Martos, M Bedu, R D Josephs, S Westwood, R I Wielgosz

Journal: Anal Bioanal Chem

PubMed ID: 38427100

Doi: 10.1007/s00216-024-05205-z

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Dependency on host vitamin B12 has shaped Mycobacterium tuberculosis Complex evolution

Authors: Elena Campos-Pardos, Santiago Uranga, Ana Picó, Ana Belén Gómez, Jesús Gonzalo-Asensio

Journal: Nat Commun

PubMed ID: 38461302

Doi: 10.1038/s41467-024-46449-8

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Spatial enhancer activation influences inhibitory neuron identity during mouse embryonic development

Authors: Elena Dvoretskova, May C Ho, Volker Kittke, Florian Neuhaus, Ilaria Vitali, Daniel D Lam, Irene Delgado, Chao Feng, Miguel Torres, Juliane Winkelmann, Christian Mayer

Journal: Nat Neurosci

PubMed ID: 38528203

Doi: 10.1038/s41593-024-01611-9

Products & Services: Molecular Biology Reagents

The Evolution and Application of a Novel DNA Aptamer Targeting Bone Morphogenetic Protein 2 for Bone Regeneration

Authors: Mengping Liu, Andrew B Kinghorn, Lin Wang, Soubhagya K Bhuyan, Simon Chi-Chin Shiu, Julian A Tanner

Journal: Molecules

PubMed ID: 38542880

Doi: 10.3390/molecules29061243

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Caspase-2 protects against ferroptotic cell death

Authors: Swati Dawar, Mariana C Benitez, Yoon Lim, Toby A Dite, Jumana M Yousef, Niko Thio, Sylvain Garciaz, Thomas D Jackson, Julia V Milne, Laura F Dagley, Wayne A Phillips, Sharad Kumar, Nicholas J Clemons

Journal: Cell Death Dis

PubMed ID: 38429264

Doi: 10.1038/s41419-024-06560-6

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Bioengineered Hydrogels Recapitulate Fibroblast Heterogeneity in Cancer

Authors: Nicholas Ching Wei Ho, Josephine Yu Yan Yap, Zixuan Zhao, Yunyun Wang, Kanishka Fernando, Constance H Li, Xue Lin Kwang, Hong Sheng Quah, Camille Arcinas, N Gopalakrishna Iyer, Eliza Li Shan Fong

Journal: Adv Sci (Weinh)

PubMed ID: 38493497

Doi: 10.1002/advs.202307129

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Rational Design of Key Enzymes to Efficiently Synthesize Phycocyanobilin in

Authors: Ziwei Wang, Jingwen Zhou, Jianghua Li, Guocheng Du, Jian Chen, Xinrui Zhao

Journal: Biomolecules

PubMed ID: 38540721

Doi: 10.3390/biom14030301

Products & Services: Proteins, Expression, Isolation and Analysis

A Novel Dual-Fc Bispecific Antibody with Enhanced Fc Effector Function

Authors: Fulai Zhou, Yinyin Ben, Hao Jiang, Siwen Tan, Guangmao Mu, Zhengxia Zha, Shuting Dong, Sheng Huang, Yijun Zhou, Ying Jin, Mark L Chiu

Journal: Biochemistry

PubMed ID: 38426700

Doi: 10.1021/acs.biochem.3c00481

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Characterization of Transthyretin Mutation G47V Associated with Hereditary Cardiac Amyloidosis

Authors: Xiaopeng He, Mengdie Wang, Jialu Sun, Zhengyang Yu, Xinyang Hu, Yu Liu, Xiaoping Lin

Journal: Cardiology

PubMed ID: 38437799

Doi: 10.1159/000538081

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A combinatorial strategy for HRV 3C protease engineering to achieve the N-terminal free cleavage

Authors: Meng Mei, Xian Fan, Yu Zhou, Faying Zhang, Guimin Zhang, Li Yi

Journal: Int J Biol Macromol

PubMed ID: 38521339

Doi: 10.1016/j.ijbiomac.2024.131066

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Characteristics of cold-adapted carbonic anhydrase and efficient carbon dioxide capture based on cell surface display technology

Authors: Yatong Wang, Quanfu Wang, Xuejing Shan, Yuwei Wu, Shumiao Hou, Ailin Zhang, Yanhua Hou

Journal: Bioresour Technol

PubMed ID: 38458264

Doi: 10.1016/j.biortech.2024.130539

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Modular vector assembly enables rapid assessment of emerging CRISPR technologies

Authors: Abby V McGee, Yanjing V Liu, Audrey L Griffith, Zsofia M Szegletes, Bronte Wen, Carolyn Kraus, Nathan W Miller, Ryan J Steger, Berta Escude Velasco, Justin A Bosch, Jonathan D Zirin, Raghuvir Viswanatha, Erik J Sontheimer, Amy Goodale, Matthew A Greene, Thomas M Green, John G Doench

Journal: Cell Genom

PubMed ID: 38484704

Doi: 10.1016/j.xgen.2024.100519

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ATX1 and HUB1/2 promote recruitment of the transcription elongation factor VIP2 to modulate the floral transition in Arabidopsis

Authors: Qianqian Lu, Wenwen Shi, Fei Zhang, Yong Ding

Journal: Plant J

PubMed ID: 38446797

Doi: 10.1111/tpj.16707

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LysSYL: a broad-spectrum phage endolysin targeting Staphylococcus species and eradicating S aureus biofilms

Authors: He Liu, Xuemei Wei, Zhefen Wang, Xiaonan Huang, Mengyang Li, Zhen Hu, Kexin Zhang, Qiwen Hu, Huagang Peng, Weilong Shang, Yi Yang, Yuting Wang, Shuguang Lu, Xiancai Rao

Journal: Microb Cell Fact

PubMed ID: 38528536

Doi: 10.1186/s12934-024-02359-4

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A Synergistic Lipid Nanoparticle Encapsulating mRNA Shingles Vaccine Induces Potent Immune Responses and Protects Guinea Pigs from Viral Challenges

Authors: Xingdi Cheng 1 2, Sujia Liu 3, Jing Sun 4, Lin Liu 3, Xinghuan Ma 3, Jingjiao Li 1 2, Bangda Fan 3, Chen Yang 1 2, Yuanyuan Zhao 1 2, Shuai Liu 1, Yixing Wen 1 2, Wei Li 1 2, Simin Sun 1, Shiwei Mi 1 2, Haonan Huo 1 2, Lei Miao 5, Hao Pan 6, Xiaolan Cui 4, Jiaqi Lin 3, Xueguang Lu 1 2

Journal: Adv Mater

PubMed ID: 38145557

Doi: 10.1002/adma.20231088

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Engineering APOBEC3A deaminase for highly accurate and efficient base editing

Authors: Lei Yang, Yanan Huo, Man Wang, Dan Zhang, Tianai Zhang, Hao Wu, Xichen Rao, Haowei Meng, Shuming Yin, Jiale Mei, Dexin Zhang, Xi Chen, Jia Lv, Meizhen Liu, Yiyun Cheng, Yuting Guan, Bo Feng, Gaojie Song, Chengqi Yi, Mingyao Liu, Fanyi Zeng, Liren Wang, Dali Li

Journal: Nat Chem Biol

PubMed ID: 38553609

Doi: 10.1038/s41589-024-01595-4

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Self-adaptive pyroptosis-responsive nanoliposomes block pyroptosis in autoimmune inflammatory diseases

Authors: Kaiwang Xu, Huang Yang, Jinghua Fang, Kaijie Qiu, Haotian Shen, Guanrui Huang, Qiangqiang Zheng, Canlong Wang, Tengjing Xu, Xinning Yu, Jiajie Wang, Yunting Lin, Jiacheng Dai, Yuting Zhong, Hongyun Song, Sunan Zhu, Siheng Wang, Zhuxing Zhou, Guang Yang, Zhengwei Mao, Zongyou Pan, Xuesong Dai

Journal: Bioactive Materials

PubMed ID: 38496034

Doi: 10.1016/j.bioactmat.2024.02.022

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G-quadruplexes control hepatitis B virus replication by promoting cccDNA transcription and phase separation in hepatocytes

Authors: Guillaume Giraud, Mélanie Rodà, Pélagie Huchon, Maud Michelet, Sarah Maadadi, Daniel Jutzi, Roland Montserret, Marc-David Ruepp, Romain Parent, Christophe Combet, Fabien Zoulim, Barbara Testoni

Journal: Nucleic Acids Res

PubMed ID: 38113270

Doi: 10.1093/nar/gkad1200

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MIWI N-terminal arginines orchestrate generation of functional pachytene piRNAs and spermiogenesis

Authors: Nicholas Vrettos, Jan Oppelt, Ansgar Zoch, Paraskevi Sgourdou, Haruka Yoshida, Brian Song, Ryan Fink, Dónal O'Carroll, Zissimos Mourelatos 1

Journal: Nucleic Acids Research

PubMed ID: 38520410

Doi: 10.1093/nar/gkae193

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Unveiling a Shield of Hope: A Novel Multiepitope-Based Immunogen for Cross-Serotype Cellular Defense against Dengue Virus

Authors: Nilanshu Manocha, Daphné Laubreton, Xavier Robert, Jacqueline Marvel, Virginie Gueguen-Chaignon, Patrice Gouet, Prashant Kumar, Madhu Khanna

Journal: Vaccines (Basel)

PubMed ID: 38543950

Doi: 10.3390/vaccines12030316

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Zoledronic Acid Accelerates ER Stress-Mediated Inflammation by Increasing PDE4B Expression in Bisphosphonate-Related Osteonecrosis of the Jaw

Authors: Qu Xz, Sun Zq, Liu L, Ong Hs

Journal: Appl Biochem Biotechnol

PubMed ID: 38523176

Doi: 10.1007/s12010-024-04859-w

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Effective Gene Therapy for Metachromatic Leukodystrophy Achieved with Minimal Lentiviral Genomic Integrations

Authors: Lucas Tricoli, Sunetra Sase, Julia Hacker, Vi Pham, Sidney Smith, Maxwell Chappell, Laura Breda, Stephanie Hurwitz, Naoto Tanaka, Carlo Castruccio Castracani, Amaliris Guerra, Zhongqi Hou, Lars Schlotawa, Karthikeyan Radhakrishnan, Peter Kurre, Rebecca Ahrens-Nicklas, Laura Adang, Adeline Vanderver, Stefano Rivella

Journal: biorxiv

PubMed ID: 38559013

Doi: 10.1101/2024.03.14.584404

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Diverse INOSITOL PHOSPHORYLCERAMIDE SYNTHASE mutant alleles of Physcomitrium patens offer new insight into complex sphingolipid metabolism

Authors: Tegan M Haslam, Cornelia Herrfurth, Ivo Feussner

Journal: New Phytol

PubMed ID: 38523559

Doi: 10.1111/nph.19667

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Post-therapeutic cure criterion in chronic Chagas disease using Trypanosoma cruzi chimeric proteins

Authors: Tycha Bianca Sabaini Pavan, Leonardo Maia Leony, Wayner Vieira de Souza, Emily Ferreira Santos, Ramona Tavares Daltro, Natalia Erdens Maron Freitas, Larissa Carvalho Medrado Vasconcelos, Fernanda Lopes Habib, Angelo Antonio Oliveira Silva, Paola Alejandra Fiorani Celedon, Daniel Dias Sampaio, Nilson Ivo Tonin Zanchin, Silvia Andrea Longhi, Fred Luciano Neves Santos

Journal: Folia Parasitol (Praha)

PubMed ID: 38526232

Doi: 10.14411/fp.2024.004

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Structural basis of U12-type intron engagement by the fully assembled human minor spliceosome

Authors: Rui Bai, Meng Yuan, Pu Zhang, Ting Luo, Yigong Shi, Ruixue Wan

Journal: Science

PubMed ID: 38484052

Doi: 10.1126/science.adn7272

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An intein-based biosensor to measure protein stability in vivo

Authors: Ahyun Son, John S Smetana, Scott Horowitz , Christopher W Lennon

Journal: Protein Sci

PubMed ID: 38380775

Doi: 10.1002/pro.4925

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Interferon-γ in the tumor microenvironment promotes the expression of B7H4 in colorectal cancer cells, thereby inhibiting cytotoxic T cells

Authors: Zhi-Liang Jing, Guang-Long Liu, Na Zhou, Dong-Yan Xu, Na Feng, Yan Lei, Li-Li Ma, Min-Shan Tang, Gui-Hui Tong, Na Tang, Yong-Jian Deng

Journal: Nature

PubMed ID: 38480774

Doi: 10.1038/s41598-024-56681-3

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Aging-induced tRNAGlu-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization

Authors: Dingfeng Li, Xinyi Gao, Xiaolin Ma, Ming Wang, Chuandong Cheng, Tian Xue, Feng Gao, Yong Shen, Juan Zhang, Qiang Liu

Journal: Cell Metab

PubMed ID: 38458203

Doi: 10.1016/j.cmet.2024.02.011.

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Occlusal force orchestrates alveolar bone homeostasis via Piezo1 in female mice

Authors: Yiling Yang, Qinggang Dai, Xin Gao, Yanfei Zhu, Mi Ri Chung, Anting Jin, Yuanqi Liu, Xijun Wang, Xiangru Huang, Siyuan Sun, Hongyuan Xu, Jingyi Liu, Lingyong Jiang

Journal: J Bone Miner Res

PubMed ID: 38477783

Doi: 10.1093/jbmr/zjae032

Products & Services: Proteins, Expression, Isolation and Analysis

Nintedanib downregulates the profibrotic M2 phenotype in cultured monocyte-derived macrophages obtained from systemic sclerosis patients affected by interstitial lung disease

Authors: Stefano Soldano, Vanessa Smith, Paola Montagna, Emanuele Gotelli, Rosanna Campitiello, Carmen Pizzorni, Sabrina Paolino, Alberto Sulli, Andrea Cere, Maurizio Cutolo

Journal: Arthritis Res Ther

PubMed ID: 38509595

Doi: 10.1186/s13075-024-03308-7

Products & Services: Proteins, Expression, Isolation and Analysis

Structural determination and kinetic analysis of the transketolase from Vibrio vulnificus reveal unexpected cooperative behavior

Authors: Rainier-Numa Georges, Lionel Ballut, Guillaume Octobre, Arnaud Comte, Laurence Hecquet, Franck Charmantray, Bastien Doumèche

Journal: Protein Sci

PubMed ID: 38145310

Doi: 10.1002/pro.4884

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Supra-biological performance of immobilized enzymes enabled by chaperone-like specific non-covalent interactions

Authors: Héctor Sánchez-Morán, Joel L Kaar, Daniel K Schwartz

Journal: Nat Commun

PubMed ID: 38485940

Doi: 10.1038/s41467-024-46719-5

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Tight junction protein cingulin variant is associated with cancer susceptibility by overexpressed IQGAP1 and Rac1-dependent epithelial-mesenchymal transition

Authors: Yi-Ting Huang, Ya-Ting Hsu, Pei-Ying Wu, Yu-Min Yeh, Peng-Chan Lin, Keng-Fu Hsu, Meng-Ru Shen

Journal: J Exp Clin Cancer Res

PubMed ID: 38424547

Doi: 10.1186/s13046-024-02987-z

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A SARS-CoV-2 Nanobody Displayed on the Surface of Human Ferritin with High Neutralization Activity

Authors: Wenrong Zhang, Haining Wang, Tong Wu, Xintao Gao, Yuting Shang, Zhifang Zhang, Xingjian Liu, Yinü Li

Journal: Int J Nanomedicine

PubMed ID: 38476285

Doi: 10.2147/IJN.S450829

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A conserved protein tyrosine phosphatase, PTPN-22, functions in diverse developmental processes in

Authors: Shaonil Binti, Adison G Linder, Philip T Edeen, David S Fay

Journal: biorxiv

PubMed ID: 38559252

Doi: 10.1101/2024.03.12.584557

Upregulation of CIRP by its agonist prevents the development of heart failure in myocardial infarction rats

Authors: Jingjing Zhang, Tao Liu, Yanzhao Wei, Jianye Peng, Gaofeng Zeng, Peng Zhong

Journal: BMC Cardiovasc Disord

PubMed ID: 38539067

Doi: 10.1186/s12872-024-03852-9

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Extracellular vesicles promote proliferation in an animal model of regeneration

Authors: Priscilla N Avalos, Lily L Wong, David J Forsthoefel

Journal: biorxiv

PubMed ID: 38712279

Doi: 10.1101/2024.03.22.586206

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Tuning Molecular Motion Enhances Intrinsic Fluorescence in Peptide Amphiphile Nanofibers

Authors: Natchayaporn Sindhurattavej, Shreya Jampana, Mai Phuong Pham, Leonardo C Romero, Anna Grace Rogers, Griffin A Stevens, Whitney C Fowler

Journal: Biomacromolecules

PubMed ID: 38508219

Doi: 10.1021/acs.biomac.4c00050

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Comparison of Neutralizing Activity between Vaccinated and Unvaccinated Hospitalized COVID-19 Patients Infected with Delta, Omicron BA1, or Omicron BA2 Variant

Authors: Keun Ju Kim, Seo-Jin Park, Seung Gyu Yun, Sang Wook Kim, Myung-Hyun Nam, Eun Kyong Shin, Eun-Ah Chang, Dae Won Park, Chang Kyu Lee, Young Kyung Yoon, Yunjung Cho

Journal: Microorganisms

PubMed ID: 38543560

Doi: 10.3390/microorganisms12030509

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Long-term monitoring of ultratrace nucleic acids using tetrahedral nanostructure-based NgAgo on wearable microneedles

Authors: Bin Yang, Haonan Wang, Jilie Kong, Xueen Fang

Journal: Nat Commun

PubMed ID: 38431675

Doi: 10.1038/s41467-024-46215-w

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Complex -glycans are important for interspecies transmission of H7 influenza A viruses

Authors: Cindy M Spruit, Diana I Palme, Tiehai Li, María Ríos Carrasco, Alba Gabarroca García, Igor R Sweet, Maryna Kuryshko, Joshua C L Maliepaard, Karli R Reiding, David Scheibner, Geert-Jan Boons, Elsayed M Abdelwhab, Robert P de Vries

Journal: J Virol

PubMed ID: 38470143

Doi: 10.1128/jvi.01941-23

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PLD3 and PLD4 synthesize -BMP, a key phospholipid enabling lipid degradation in lysosomes

Authors: Shubham Singh, Ulrich Dransfeld, Yohannes Ambaw, Joshua Lopez-Scarim, Robert V Farese, Tobias C Walther

Journal: biorxiv

PubMed ID: 38562702

Doi: 10.1101/2024.03.21.586175

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Vesicular translocation of PARP-1 to cytoplasm causes ADP-ribosylation and disassembly of vimentin filaments during microglia activation induced by LPS

Authors: Ruiqi Chen, Lirui Xie, Yang Fan, Xiangmei Hua, Chang Y Chung

Journal: Front Cell Neurosci

PubMed ID: 38590714

Doi: 10.3389/fncel.2024.1363154

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of CEP peptides encoded by the tobacco (Nicotiana tabacum) genome and characterization of their roles in osmotic and salt stress responses

Authors: Xiaolu Pan, Zhichao Deng, Rongrong Wu, Yalun Yang, Sayed Abdul Akher, Wei Li, Zenglin Zhang, Yongfeng Guo

Journal: Plant Physiol Biochem

PubMed ID: 38518396

Doi: 10.1016/j.plaphy.2024.108525

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Derivation of a novel antimicrobial peptide from the Red Sea Brine Pools modified to enhance its anticancer activity against U2OS cells

Authors: Mona Elradi, Ahmed I Ahmed, Ahmed M Saleh, Khaled M A Abdel-Raouf, Lina Berika, Yara Daoud, Asma Amleh

Journal: BMC Biotechnol

PubMed ID: 38491556

Doi: 10.1186/s12896-024-00835-8

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Variation of gene expression of fatty acid acyl CoA reductase associated with wax secretion of a scale insect, Ericerus pela, and identification of its regulation factors through the accessible chromatin analyses and yeast one-hybrid

Authors: Zuoyi Fu, Yuanchong Shi, Shuhui Yu, Qiuyu Zhao, Haifeng Mo, Pu Yang

Journal: Arch Insect Biochem Physiol

PubMed ID: 38500444

Doi: 10.1002/arch.22101

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High temperature delays and low temperature accelerates evolution of a new protein phenotype

Authors: Jia Zheng, Ning Guo, Yuxiang Huang, Xiang Guo, Andreas Wagner

Journal: Nat Commun

PubMed ID: 38553445

Doi: 10.1038/s41467-024-46332-6

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Mutagenesis and functional analysis of the varicella-zoster virus portal protein

Authors: Melissa A Visalli, Dakota J Nale Lovett, Ellyn M Kornfeind, Haley Herrington, Yi Tian Xiao, Daniel Lee, Patience Plair, S Garrett Wilder, Bret K Garza, Ashton Young, Robert J Visalli

Journal: J Virol

PubMed ID: 38517165

Doi: 10.1128/jvi.00603-23

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Tropomyosin induces the synthesis of magnesian calcite in sea urchin spines

Authors: Yugo Kato, Woosuk Ha, Zehua Zheng, Lumi Negishi, Jun Kawano, Yoshihisa Kurita, Hitoshi Kurumizaka, Michio Suzuki

Journal: J Struct Biol

PubMed ID: 38432597

Doi: 10.1016/j.jsb.2024.108074

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Transport-controlled growth decoupling for self-induced protein expression with a glycerol-repressible genetic circuit

Authors: Alvaro R Lara, Flavio Kunert, Vincent Vandenbroucke, Hilal Taymaz-Nikerel, Luz María Martínez, Juan-Carlos Sigala, Frank Delvigne, Guillermo Gosset, Jochen Büchs

Journal: Biotechnol Bioeng

PubMed ID: 38470342

Doi: 10.1002/bit.28697

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