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Oral delivery of therapeutic proteins by engineered bacterial type zero secretion system

Authors: Xu Gong , Shan Liu , Bozhang Xia , Yichen Wan , Shuyi Zhang , Baoyan Zhang , Zehao Wang , Junge Chen , Fei Xiao , Xing-Jie Liang , Yun Yang

Journal: Nat Commun

PubMed ID: 39984501

Doi: 10.1038/s41467-025-57153-6

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EXPERT expands prime editing efficiency and range of large fragment edits

Authors: Youcai Xiong , Yinyu Su , Ruigao He , Xiaosong Han , Sheng Li , Minghuan Liu , Xiaoning Xi , Zijia Liu , Heng Wang , Shengsong Xie , Xuewen Xu , Kui Li , Jifeng Zhang , Jie Xu , Xinyun Li , Shuhong Zhao , Jinxue Ruan

Journal: Nat Commun

PubMed ID: 39939583

Doi: 10.1038/s41467-025-56734-9

Products & Services: Gene Synthesis

Self-assembly GSH response based Buforin IIb-Olaparib nanocombination synergistically promotes DNA damage for prostate cancer immunotherapy

Authors: Maosong Hu , Yuyu Zhu , Xinyi Tang , Jing Xu , Hanbin Ma , Zhihan Chen , Duo Chen , Wenyuan Wu , Xialin Chen , Rongrong He , Jing Zhou , Jinao Duan , Weiguo Chen , Hongyue Ma

Journal: Chemical Engineering Journal

Doi: 10.1016/j.cej.2025.160862

Products & Services: Peptide Synthesis

Deciphering molecular specificity in MCL-1/BAK interaction and its implications for designing potent MCL-1 inhibitors

Authors: Hudie Wei, Haolan Wang, Shuang Xiang, Jiaqi Wang, Lingzhi Qu, Xiaojuan Chen, Ming Guo, Xiaoyun Lu, Yongheng Chen

Journal: Cell Death Differ

PubMed ID: 39901037

Doi: 10.1038/s41418-025-01454-2

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Expanding Cas12a Activity Control with an RNA G-Quadruplex at the 5′ end of CRISPR RNA

Authors: Wenjuan Huang, Jiaqi Wang, Cheng Wang, Yuanfang Liu, Wentao Li, Qiaozhen Chen, Junqiu Zhai, Zhenyang Xiang, Chaoxing Liu

Journal: Advanced Science

PubMed ID: 39721016

Doi: 10.1002/advs.202411305

Products & Services: Catalog Gene Editing

The serine protease DPP9 and the redox sensor KEAP1 form a mutually inhibitory complex

Authors: Lydia P. Tsamouri; Jeffrey C. Hsiao; Daniel A. Bachovchin

Journal: The Journal of Biological Chemistry

PubMed ID: 39615677

Doi: 10.1016/j.jbc.2024.108034

Double antibody sandwich ELISA based on rabbit monoclonal antibody targeting gD protein for the detection of bovine herpesvirus 1

Authors: Qiang Liu, Xiaoxia Niu, Lingling Jiang, Gang Zhang, Pu Wang, Sinong Zhang, Weifeng Gao, Huichen Guo, Yujiong Wang, Yong Li

Journal: Int J Biol Macromol

PubMed ID: 39929469

Doi: 10.1016/j.ijbiomac.2025.140671

Products & Services: Gene Synthesis

DNA tetrahedron nanomedicine for enhanced antitumor and antimetastatic effect through the amplification of mitochondrial oxidative stress

Authors: Zixuan Chen , Zhaoyan Tian , Yafeng Wu , Songqin Liu

Journal: Acta Biomater

PubMed ID: 39922515

Doi: 10.1016/j.actbio.2025.02.011

Products & Services: Protein and Antibody Isolation

Macrophage SUCLA2 coupled glutaminolysis manipulates obesity through AMPK

Authors: Chang Peng, Haowen Jiang, Liya Jing, Wenhua Yang, Xiaotong Guan, Hanlin Wang, Sike Yu, Yutang Cao, Min Wang, Huan Ma, Zan Lv, Hongyu Gu, Chunmei Xia, Xiaozhen Guo, Bin Sun, Aili Wang, Cen Xie, Wenbiao Wu, Luyiyi Lu, Jiayi Song, Saifei Lei, Rui Wu, Yi Zang, Erjiang Tang, Jia Li

Journal: Nat Commun

PubMed ID: 39966410

Doi: 10.1038/s41467-025-57044-w

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PSKH1 kinase activity is differentially modulated via allosteric binding of Ca2+ sensor proteins

Authors: Christopher R Horne, Toby A Dite, Samuel N Young, Lucy J Mather, Laura F Dagley, Jared L Johnson, Tomer M Yaron-Barir, Emily M Huntsman, Leonard A Daly, Dominic P Byrne, Antonia L Cadell, Boaz H Ng, Jumana Yousef, Dylan H Multari, Lianju Shen, Luke M McAloon, Gerard Manning, Mark A Febbraio, Anthony R Means, Lewis C Cantley, Maria C Tanzer, David R Croucher, Claire E Eyers, Patrick A Eyers, John W Scott, James M Murphy

Journal: Proc Natl Acad Sci U S A

PubMed ID: 39964718

Doi: 10.1073/pnas.2420961122

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Enhancing mRNA translation efficiency by introducing sequence optimized AU-rich elements in 3′ UTR via HuR anchorage

Authors: Xinghuan Ma , Sujia Liu , Bangda Fan , Danni Jin , Lei Miao , Lin Liu , Shubo Du , Jiaqi Lin

Journal: Mol Ther Nucleic Acids

PubMed ID: 40125272

Doi: doi.org/10.1016/j.omtn.2025.102485

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Controllable intein splicing and N-terminal cleavage at mesophilic temperatures

Authors: Taylor A McNeal, Joel Weinberger, Geraldy L S Liman, Tia M Ariagno, David W Wood, Thomas J Santangelo, Christopher W Lennon

Journal: Front Bioeng Biotechnol

PubMed ID: 39991137

Doi: 10.3389/fbioe.2025.1543573

Products & Services: Gene Synthesis Mutagenesis Services

Structural and mechanistic insights into the activation of a short prokaryotic argonaute system from archaeon Sulfolobus islandicus

Authors: Zhikang Dai, Yu Chen, Zeyuan Guan, Xueting Chen, Keyi Tan, Kaiyue Yang, Xuhui Yan, Yidong Liu, Zhou Gong, Wenyuan Han, Tingting Zou

Journal: Nucleic Acids Res

PubMed ID: 39898546

Doi: 10.1093/nar/gkaf059

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Molecular determinants of cross-strain influenza A virus recognition by αβ T cell receptors

Authors: Sergio M Quiñones-Parra, Stephanie Gras, Thi H O Nguyen, Carine Farenc, Christopher Szeto, Louise C Rowntree, Priyanka Chaurasia, Sneha Sant, Adrianus C M Boon, Dhilshan Jayasinghe, Guus F Rimmelzwaan, Jan Petersen, Peter C Doherty, Adam P Uldrich, Dene R Littler, Jamie Rossjohn, Katherine Kedzierska

Journal: Science immunology

PubMed ID: 39919196

Doi: 10.1126/sciimmunol.adn3805

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Structure of the tilapia lake virus nucleoprotein bound to RNA

Authors: Benoît Arragain, Martin Pelosse, Karine Huard, Stephen Cusack

Journal: Nucleic Acids Res

PubMed ID: 39995042

Doi: 10.1093/nar/gkaf112

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Bacteria encode post-mortem protein catabolism that enables altruistic nutrient recycling

Authors: Savannah E R Gibson, Isabella Frost, Stephen J Hierons, Tessa Moses, Wilson C K Poon, Stuart A West, Martin J Cann

Journal: Nature Communications

PubMed ID: 39948360

Doi: 10.1038/s41467-025-56761-6

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Genetic regulation of TERT splicing affects cancer risk by altering cellular longevity and replicative potential

Authors: Oscar Florez-Vargas, Michelle Ho, Maxwell H Hogshead, Brenen W Papenberg, Chia-Han Lee, Kaitlin Forsythe, Kristine Jones, Wen Luo, Kedest Teshome, Cornelis Blauwendraat, Kimberly J Billingsley, Mikhail Kolmogorov, Melissa Meredith, Benedict Paten, Raj Chari, Chi Zhang, John S Schneekloth, Mitchell J Machiela, Stephen J Chanock, Shahinaz M Gadalla, Sharon A Savage, Sam M Mbulaiteye, Ludmila Prokunina-Olsson

Journal: Nature Communications

PubMed ID: 39956830

Doi: 10.1038/s41467-025-56947-y

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CHAMP1 complex directs heterochromatin assembly and promotes homology-directed DNA repair

Authors: Feng Li, Tianpeng Zhang, Aleem Syed, Amira Elbakry, Noella Holmer, Huy Nguyen, Sirisha Mukkavalli, Roger A Greenberg, Alan D D'Andrea

Journal: Nature Communications

PubMed ID: 39962076

Doi: 10.1038/s41467-025-56834-6

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RNA neoantigen vaccines prime long-lived CD8+ T cells in pancreatic cancer

Authors: Zachary Sethna, Pablo Guasp, Charlotte Reiche, Martina Milighetti, Nicholas Ceglia, Erin Patterson,on Jay Lihm, George Payne, Olga Lyudovyk, Luis A Rojas, Nan Pang, Akihiro Ohmoto, Masataka Amisaki, Abderezak Zebboudj, Zagaa Odgerel, Emmanuel M Bruno, Siqi Linsey Zhang, Charlotte Cheng, Yuval Elhanati, Evelyna Derhovanessian, Luisa Manning, Felicitas Müller, Ina Rhee, Mahesh Yad,av Taha Merghoub, Jedd D Wolchok, Olca Basturk, Mithat Gönen, Andrew S Epstein, Parisa Momtaz, Wungki Park, Ryan Sugarman, Anna M Varghese, Elizabeth Won, Avni Desai, Alice C Wei, Michael I D'Angelica, T Peter Kingham, Kevin C Soares, William R Jarnagin, Jeffrey Drebin, Eileen M O'Reilly, Ira Mellman, Ugur Sahin, Özlem Türeci, Benjamin D Greenbaum, Vinod P Balachandran

Journal: Nature

PubMed ID: 39972124

Doi: 10.1038/s41586-024-08508-4

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Cooperative nutrient scavenging is an evolutionary advantage in cancer

Authors: Gizem Guzelsoy, Setiembre D Elorza, Manon Ros, Logan T Schachtner, Makiko Hayashi, Spencer Hobson-Gutierrez, Parker Rundstrom, Julia S Brunner, Ray Pillai, William E Walkowicz, Lydia W S Finley, Maxime Deforet, Thales Papagiannakopoulos, Carlos Carmona-Fontaine

Journal: Nature

PubMed ID: 39972131

Doi: 10.1038/s41586-025-08588-w

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Conserved immunomodulation and variation in host association by Xanthomonadales commensals in Arabidopsis root microbiota

Authors: Jana Ordon、Elke Logemann、Louis-Philippe Maier、Tak Lee、Eik Dahms、Anniek Oosterwijk、Jose Flores-Uribe、Shingo Miyauchi、Lucas Paoli、Sara Christina Stolze、Hirofumi Nakagami、Georg Felix、Ruben Garrido-Oter、Ka-Wai Ma 和 Paul Schulze-Lefert

Journal: Nat Plants

PubMed ID: 39972185

Doi: 10.1038/s41477-025-01918-w

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Structural basis of ssDNA-guided NADase activation of prokaryotic SPARTA system

Authors: Rong Hu, Chenmin Guo, Xiaotian Liu, Yuanyi Lin, Zixin Yang, Zhixin Li, Ye Yang, Erman Ma, Yiyi Li, Jiyun Chen, Liang Liu

Journal: Nucleic Acids Res

PubMed ID: 39997222

Doi: 10.1093/nar/gkaf110

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Reversible ubiquitination conferred by domain shuffling controls paired NLR immune receptor complex homeostasis in plant immunity

Authors: Zhiyi Chen, Jianhua Huang, Jianyu Li, Frank L. H. Menke, Jonathan D. G. Jones & Hailong Guo

Journal: Nature Communications

Doi: 10.1038/s41467-025-57231-9

Products & Services: Protein and Antibody Isolation

ABC transporter activity is affected by the size of lipid nanodiscs

Authors: Annabella Nouel Barreto, Luis G Cuello, Maria E Zoghbi

Journal: FEBS Letters

PubMed ID: 39748569

Doi: 10.1002/1873-3468.15096

Products & Services: Gene Synthesis Custom Vector Construction

Molecular mechanisms of drug resistance and compensation in SARS-CoV-2 main protease: the interplay between E166 and L50

Authors: Sarah N. Zvornicanin; Ala M. Shaqra; Julia Flynn; Heidi Carias Martinez; Weiping Jia; Stephanie Moquin; Dustin Dovala; Daniel N. Bolon; Nese Kurt Yilmaz; Celia A. Schiffer

Journal: MBio

PubMed ID: 40183562

Doi: 10.1128/mbio.04068-24

Products & Services: Peptide Synthesis

The serine protease DPP9 and the redox sensor KEAP1 form a mutually inhibitory complex

Authors: Lydia P. Tsamouri; Jeffrey C. Hsiao; Daniel A. Bachovchin

Journal: The Journal of Biological Chemistry

PubMed ID: 39615677

Doi: 10.1016/j.jbc.2024.108034

The serine protease DPP9 and the redox sensor KEAP1 form a mutually inhibitory complex

Authors: Lydia P. Tsamouri; Jeffrey C. Hsiao; Daniel A. Bachovchin

Journal: The Journal of Biological Chemistry

PubMed ID: 39615677

Doi: 10.1016/j.jbc.2024.108034

Allogeneic CD33-directed CAR-NKT cells for the treatment of bone marrow-resident myeloid malignancies

Authors: Yan-Ruide Li, Ying Fang, Siyue Niu, Yichen Zhu, Yuning Chen, Zibai Lyu, Enbo Zhu, Yanxin Tian, Jie Huang, Valerie Rezek, Scott Kitchen, Tzung Hsiai, Jin J Zhou, Pin Wang, Wanxing Chai-Ho, Sunmin Park, Christopher S Seet, Caspian Oliai, Lili Yang

Journal: Nature Communications

PubMed ID: 39893165

Doi: 10.1038/s41467-025-56270-6

Products & Services: Gene Fragments

Massively parallel variant-to-function mapping determines functional regulatory variants of non-small cell lung cancer

Authors: Congcong Chen, Yang Li, Yayun Gu, Qiqi Zhai, Songwei Guo, Jun Xiang, Yuan Xie, Mingxing An, Chenmeijie Li, Na Qin, Yanan Shi, Liu Yang, Jun Zhou, Xianfeng Xu, Ziye Xu, Kai Wang, Meng Zhu, Yue Jiang, Yuanlin He, Jing Xu, Rong Yin, Liang Chen, Lin Xu, Juncheng Dai, Guangfu Jin, Zhibin Hu, Cheng Wang, Hongxia Ma, Hongbing Shen

Journal: Nature Communications

PubMed ID: 39910069

Doi: 10.1038/s41467-025-56725-w

Products & Services: Gene Synthesis

Multiple independent acquisitions of ACE2 usage in MERS-related coronaviruses

Authors: Cheng-Bao Ma, Chen Liu, Young-Jun Park, Jingjing Tang, Jing Chen, Qing Xiong, Jimin Lee, Cameron Stewart, Daniel Asarnow, Jack Brown, M Alejandra Tortorici, Xiao Yang, Ye-Hui Sun, Yuan-Mei Chen, Xiao Yu, Jun-Yu Si, Peng Liu, Fei Tong, Mei-Ling Huang, Jing Li, Zheng-Li Shi, Zengqin Deng, David Veesler, Huan Yan

Journal: Cell

PubMed ID: 39922191

Doi: 10.1016/j.cell.2024.12.031

Products & Services: Codon Optimization

Molecular basis of convergent evolution of ACE2 receptor utilization among HKU5 coronaviruses

Authors: Young-Jun Park, Chen Liu, Jimin Lee, Jack T Brown, Cheng-Bao Ma, Peng Liu, Risako Gen, Qing Xiong, Samantha K Zepeda, Cameron Stewart, Amin Addetia, Caroline J Craig, M Alejandra Tortorici, Abeer N Alshukairi, Tyler N Starr, Huan Yan, David Veesler

Journal: Cell

PubMed ID: 39922192

Doi: 10.1016/j.cell.2024.12.032

Products & Services: Codon Optimization

Orphan G protein-coupled receptor GPRC5B controls macrophage function by facilitating prostaglandin E receptor 2 signaling

Authors: Jeonghyeon Kwon, Haruya Kawase, Kenny Mattonet, Stefan Guenther, Lisa Hahnefeld, Jamal Shamsara, Jan Heering, Michael Kurz, Sina Kirchhofer, Cornelius Krasel, Michaela Ulrich, Margherita Persechino, Sripriya Murthy, Cesare Orlandi, Christian D Sadik, Gerd Geisslinger, Moritz Bünemann, Peter Kolb, Stefan Offermanns, Nina Wettschureck

Journal: Nature Communications

PubMed ID: 39920161

Doi: 10.1038/s41467-025-56713-0

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Structural basis for complement receptor engagement and virus neutralization through Epstein-Barr virus gp350

Authors: M Gordon Joyce, Wei Bu, Wei-Hung Chen, Rebecca A Gillespie, Sarah F Andrews, Adam K Wheatley, Yaroslav Tsybovsky, Jaime L Jensen, Tyler Stephens, Madhu Prabhakaran, Brian E Fisher, Sandeep R Narpala, Meghna Bagchi, Adrian B McDermott, Gary J Nabel, Peter D Kwong, John R Mascola, Jeffrey I Cohen, Masaru Kanekiyo

Journal: Immunity

PubMed ID: 39909035

Doi: 10.1016/j.immuni.2025.01.010

Products & Services: Recombinant Antibody Expression

Design of quinoline SARS-CoV-2 papain-like protease inhibitors as oral antiviral drug candidates

Authors: Prakash Jadhav, Xueying Liang, Ahmadullah Ansari, Bin Tan, Haozhou Tan, Kan Li, Xiang Chi, Alexandra Ford, Francesc Xavier Ruiz, Eddy Arnold, Xufang Deng, Jun Wang

Journal: Nature Communications

PubMed ID: 39948104

Doi: 10.1038/s41467-025-56902-x

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Nucleotide-induced hyper-oligomerization inactivates transcription termination factor ρ

Authors: Bing Wang, Nelly Said, Tarek Hilal, Mark Finazzo, Markus C Wahl, Irina Artsimovitch

Journal: Nature Communications

PubMed ID: 39952913

Doi: 10.1038/s41467-025-56824-8

Products & Services: Protein Electrophoresis and Western

The CXCL8/MAPK/hnRNP-K axis enables susceptibility to infection by EV-D68, rhinovirus, and influenza virus in vitro

Authors: Qingran Yang, Haoran Guo, Huili Li, Zhaoxue Li, Fushun Ni, Zhongmei Wen, Kai Liu, Huihui Kong, Wei Wei

Journal: Nature Communications

PubMed ID: 39962077

Doi: 10.1038/s41467-025-57094-0

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Potent and selective SETDB1 covalent negative allosteric modulator reduces methyltransferase activity in cells

Authors: Mélanie Uguen, Devan J Shell, Madhushika Silva, Yu Deng, Fengling Li, Magdalena M Szewczyk, Ka Yang, Yani Zhao, Michael A Stashko, Jacqueline L Norris-Drouin, Jarod M Waybright, Serap Beldar, Justin M Rectenwald, Angie L Mordant, Thomas S Webb, Laura E Herring, Cheryl H Arrowsmith, Suzanne Ackloo, Steven P Gygi, Robert K McGinty, Dalia Barsyte-Lovejoy, Pengda Liu, Levon Halabelian, Lindsey I James, Kenneth H Pearce, Stephen V Frye

Journal: Nature Communications

PubMed ID: 39994194

Doi: 10.1038/s41467-025-57005-3

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Dual functional POGases from bacteria encompassing broader O-glycanase and adhesin activities

Authors: Linjiao Zhou, Uriel Ortega-Rodriguez, Matthew J Flores, Yasuyuki Matsumoto, John Q Bettinger, Wells W Wu, Yaqin Zhang, Su-Ryun Kim, Thomas G Biel, Jordan D Pritts, Rong-Fong Shen, V Ashutosh Rao, Tongzhong Ju.

Journal: Nature Communications

PubMed ID: 40000644

Doi: 10.1038/s41467-025-57143-8

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A ribosome-interacting jumbophage protein associates with the phage nucleus to facilitate efficient propagation

Authors: Wichanan Wannasrichan; Sucheewin Krobthong; Chase J. Morgan; Emily G. Armbruster; Milan Gerovac; Yodying Yingchutrakul; Patompon Wongtrakoongate; J rg Vogel; Chanat Aonbangkhen; Poochit Nonejuie; Joe Pogliano; Vorrapon Chaikeeratisak

Journal: PLOS Pathogens

PubMed ID: 39992933

Doi: 10.1371/journal.ppat.1012936

Structural Plasticity of RRE Stem-Loop II Modulates Nuclear Export of HIV-1 RNA

Authors: Manju Ojha; Lucia Hudson; Amanda Photenhauer; Trinity Zang; Lauren Lerew; len Ekesan; Jason Daniels; Megan Nguyen; Hardik Paudyal; Darrin M. York; Melanie D. Ohi; Jan Marchant; Paul D. Bieniasz; Deepak Koirala

Journal: biorxiv

PubMed ID: 40060702

Doi: 10.1101/2025.02.20.639096

Molecular mechanisms of drug resistance and compensation in SARS-CoV-2 main protease: the interplay between E166 and L50

Authors: Sarah N. Zvornicanin; Ala M. Shaqra; Julia Flynn; Heidi Carias Martinez; Weiping Jia; Stephanie Moquin; Dustin Dovala; Daniel N. Bolon; Nese Kurt Yilmaz; Celia A. Schiffer

Journal: MBio

PubMed ID: 40183562

Doi: 10.1128/mbio.04068-24

Products & Services: Peptide Synthesis

Molecular mechanisms of drug resistance and compensation in SARS-CoV-2 main protease: the interplay between E166 and L50

Authors: Sarah N. Zvornicanin; Ala M. Shaqra; Julia Flynn; Heidi Carias Martinez; Weiping Jia; Stephanie Moquin; Dustin Dovala; Daniel N. Bolon; Nese Kurt Yilmaz; Celia A. Schiffer

Journal: MBio

PubMed ID: 40183562

Doi: 10.1128/mbio.04068-24

Products & Services: Peptide Synthesis

The O-glycosyltransferase C1GALT1 promotes EWSR1::FLI1 expression and is a therapeutic target for Ewing sarcoma

Authors: Shahid Banday, Alok K Mishra, Romana Rashid, Tianyi Ye, Amjad Ali, Junhui Li, Jason T Yustein, Michelle A Kelliher, Lihua Julie Zhu, Sara K Deibler, Sunil K Malonia, Michael R Green

Journal: Nature Communications

PubMed ID: 39894896

Doi: 10.1038/s41467-025-56632-0

Products & Services: Plasmid DNA Preparation

Structural basis of SIRT7 nucleosome engagement and substrate specificity

Authors: Carlos Moreno-Yruela, Babatunde E Ekundayo, Polina N Foteva, Dongchun Ni, Esther Calvino-Sanles, Henning Stahlberg, Beat Fierz

Journal: Nature Communications

PubMed ID: 39900593

Doi: 10.1038/s41467-025-56529-y

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Synthetic lethality of mRNA quality control complexes in cancer

Authors: Vivian Prindle, Adam E Richardson, Kimberly R Sher, Sarah Kongpachith, Kaitlin Kentala, Sakina Petiwala, Dong Cheng, Deborah Widomski, Phuong Le, Maricel Torrent, Anlu Chen, Stephen Walker, Marianne B Palczewski, Diya Mitra, Vlasios Manaves, Xu Shi, Charles Lu, Stephanie Sandoval, Zoltan Dezso, F Gregory Buchanan, Daniel Verduzco, Brian Bierie, Jonathan A Meulbroek, William N Pappano, Joshua P Plotnik

Journal: Nature

PubMed ID: 39910291

Doi: 10.1038/s41586-024-08398-6

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Antibody prophylaxis may mask subclinical SIV infections in macaques

Authors: Christopher A Gonelli, Hannah A D King, SungYoul Ko, Christine M Fennessey, Nami Iwamoto, Rosemarie D Mason, Ashley Heimann, Dillon R Flebbe, John-Paul Todd, Kathryn E Foulds, Brandon F Keele, Jeffrey D Lifson, Richard A Koup, Mario Roederer.

Journal: Nature

PubMed ID: 39910294

Doi: 10.1038/s41586-024-08500-y

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Structural basis of inhibition of human NaV1.8 by the tarantula venom peptide Protoxin-I

Authors: Bryan Neumann, Stephen McCarthy, Shane Gonen

Journal: Nature Communications

PubMed ID: 39920100

Doi: 10.1038/s41467-024-55764-z

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Co-translational protein aggregation and ribosome stalling as a broad-spectrum antibacterial mechanism

Authors: Laleh Khodaparast, Ladan Khodaparast, Ramon Duran-Romaña, Guiqin Wu, Bert Houben, Wouter Duverger, Matthias De Vleeschouwer, Katerina Konstantoulea, Fleur Nysen, Thomas Schalck, Daniel J Curwen, Lisandra L Martin, Sebastien Carpentier, Bernard Scorneaux, Jan Michiels, Joost Schymkowitz, Frederic Rousseau

Journal: Nature Communications

PubMed ID: 39939597

Doi: 10.1038/s41467-025-56873-z

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Cascaded immunotherapy with implantable dual-drug depots sequentially releasing STING agonists and apoptosis inducers

Authors: Kai Li, Xuan Yu, Yanteng Xu, Haixia Wang, Zheng Liu, Chong Wu, Xing Luo, Jiancheng Xu, Youqiang Fang, Enguo Ju, Shixian Lv, Hon Fai Chan, Yeh-Hsing Lao, Weiling He, Yu Tao, Mingqiang Li

Journal: Nature Communications

PubMed ID: 39952937

Doi: 10.1038/s41467-025-56407-7

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Proteasomes accumulate in the plant apoplast where they participate in microbe-associated molecular pattern (MAMP)-triggered pathogen defense

Authors: Hana Zand Karimi, Kuo-En Chen, Marilee Karinshak, Xilin Gu, Jason K Sello, Richard D Vierstra

Journal: Nature Communications

PubMed ID: 39952938

Doi: 10.1038/s41467-025-56594-3

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