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Rapid simulation of glycoprotein structures by grafting and steric exclusion of glycan conformer libraries

Authors: Yu-Xi Tsai, Ning-En Chang, Klaus Reuter, Hao-Ting Chang, Tzu-Jing Yang, Sören von Bülow, Vidhi Sehrawat, Noémie Zerrouki, Matthieu Tuffery, Michae Gecht, Isabell Louise Grothaus, Lucio Colombi Ciacchi, Yong-Sheng Wang, Min-Feng Hsu, Kay-Hooi Khoo, Gerhard Hummer, Shang-Te Danny Hsu, Cyril Hanus , Mateusz Sikora

Journal: Cell

PubMed ID: 38428397

Doi: 10.1016/j.cell.2024.01.034

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Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase

Authors: Julia Lederhofer, Yaroslav Tsybovsky, Lam Nguyen, Julie E Raab, Adrian Creanga, Tyler Stephens, Rebecca A Gillespie, Hubza Z Syeda, Brian E Fisher, Michelle Skertic , Christina Yap, Andrew J Schaub, Reda Rawi, Peter D Kwong, Barney S Graham, Adrian B McDermott , Sarah F Andrews , Neil P King , Masaru Kanekiyo

Journal: Immunity

PubMed ID: 38430907

Doi: 10.1016/j.immuni.2024.02.003

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PP2A and GSK3 act as modifiers of FUS-ALS by modulating mitochondrial transport

Authors: Paraskevi Tziortzouda , Jolien Steyaert , Wendy Scheveneels , Adria Sicart , Katarina Stoklund Dittlau , Adriana Margarida Barbosa Correia , Thibaut Burg , Arun Pal , Andreas Hermann , Philip Van Damme , Thomas G Moens , Ludo Van Den Bosch

Journal: Acta Neuropathol

PubMed ID: 38363426

Doi: 10.1007/s00401-024-02689-y

Products & Services: Peptide Synthesis

ZSCAN10 deficiency causes a neurodevelopmental disorder with characteristic oto-facial

Authors: Lucia Laugwitz, Fubo Cheng, Stephan C Collins, Alexander Hustinx, Nicolas Navarro, Simon Welsch, Helen Cox, Tzung-Chien Hsieh, Aswinkumar Vijayananth, Rebecca Buchert, Benjamin Bender, Stephanie Efthymiou, David Murphy, Faisal Zafar, Nuzhat Rana, Ute Grasshoff, Ruth J Falb, Mona Grimmel, Annette Seibt, Wenxu Zheng, Hamid Ghaedi, Marie Thirion, Sébastien Couette, Reza Azizimalamiri, Saeid Sadeghian, Hamid Galehdari, Mina Zamani, Jawaher Zeighami, Alireza Sedaghat, Samira Molaei Ramshe, Ali Zare, Behnam Alipoor, Dirk Klee,

Journal: Brain

PubMed ID: 38386308

Doi: 10.1093/brain/awae058

Products & Services: PCR Cloning and Subcloning

Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks

Authors: Carla A Jaeger-Ruckstuhl Yun Lo, Elena Fulton , Olivia G Waltner, Tamer B Shabaneh , Sylvain Simon , Pranav V Muthuraman , Colin E Correnti , Oliver J Newsom , Ian A Engstrom , Sami B Kanaan , Shruti S Bhise , Jobelle M C Peralta , Raymond Ruff , Jason P Price , Sylvia M Stull , Andrew R Stevens , Grace Bugos, Mitchell G Kluesner , Valentin Voillet, Vishaka Muhunthan, Fionnuala Morrish, James M Olson , Raphaël Gottado , Jay F Sarthy, Steven Henikoff , Lucas B Sullivan, Scott N Furlan, Stanley R Riddell

Journal: Immunity

PubMed ID: 38354704

Doi: 10.1016/j.immuni.2024.01.011

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Local structural preferences in shaping tau amyloid polymorphism

Authors: Nikolaos Louros , Martin Wilkinson , Grigoria Tsaka , Meine Ramakers , Chiara Morelli , Teresa Garcia , Rodrigo Gallardo , Sam D'Haeyer , Vera Goossens , Dominique Audenaert , Dietmar Rudolf Thal , Ian R Mackenzie , Rosa Rademakers , Neil A Ranson , Sheena E Radford , Frederic Rousseau , Joost Schymkowitz

Journal: Nat Commun

PubMed ID: 38310108

Doi: 10.1038/s41467-024-45429-2

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Identification of closely related species in through Analysis of Whole-Genome

Authors: Guihong Qi, Lijun Hao, Yutong Gan, Tianyi Xin, Qian Lou, Wenjie Xu, Jingyuan Song

Journal: Front Microbiol

PubMed ID: 38450170

Doi: 10.3389/fmicb.2024.1323572

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Antiviral activity of immunosuppressors alone and in combination against human adenovirus and cytomegalovirus

Authors: Marta Carretero-Ledesma, Manuela Aguilar-Guisado, Judith Berastegui-Cabrera, María Balsera-Manzanero, Jerónimo Pachón, Elisa Cordero, Javier Sánchez-Céspedes

Journal: Int J Antimicrob Agents

PubMed ID: 38401774

Doi: 10.1016/j.ijantimicag.2024.107116

Products & Services: PCR Cloning and Subcloning

A phenylalanine-free recombinant nutritional protein for the dietary management of phenylketonuria

Authors: Yvonne Mücke, Natalia Jablonka, Nicole Rimann, Hiu Man Grisch-Chan, Bernhard Hoffmann, Stefan Schillberg, Beat Thöny, Stefan Rasche

Journal: J Inherit Metab Dis

PubMed ID: 38390655

Doi: 10.1002/jimd.12719

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Authors: Chenwei Wang, Jiewen Chen, Jingyao Li, Zhihong Xu, Lihong Huang, Qian Zhao, Lei Chen, Xiaolong Liang, Hai Hu, Gang Li, Chengjie Xiong, Bin Wu, Hua You, Danyi Du, Xiaoling Wang, Hongle Li, Zibing Wang, Lin Chen

Journal: J Clin Invest

PubMed ID: 38412034

Doi: 10.1172/JCI172092

Products & Services: Molecular Biology Reagents

The molecular interaction pattern of lenvatinib enables inhibition of wild-type or kinase-mutated FGFR2-driven cholangiocarcinoma

Authors: Stephan Spahn, Fabian Kleinhenz, Ekaterina Shevchenko, Aaron Stahl, Yvonne Rasen, Christine Geisler, Kristina Ruhm, Marion Klaumuenzer, Thales Kronenberger, Stefan A Laufer, Holly Sundberg-Malek, Khac Cuong Bui, Marius Horger, Saskia Biskup, Klaus Schulze-Osthoff, Markus Templin, Nisar P Malek, Antti Poso, Michael Bitzer

Journal: Nat Commun

PubMed ID: 38346946

Doi: 10.1038/s41467-024-45247-6

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Molecular Characterization of Plant Volatile Compound Interactions with Odorant-Binding Proteins

Authors: Qi Qian, Xin Guo, Lingjie Wu, Jiarong Cui, Huiying Gao, Yajun Yang, Hongxing Xu, Zhongxian Lu, Pingyang Zhu

Journal: Plants (Basel)

PubMed ID: 38498446

Doi: 10.3390/plants13040479

Products & Services: Proteins, Expression, Isolation and Analysis

Cytokine responses to major human Cytomegalovirus antigens in mouse model

Authors: Sahar Essa, Hussain A Safar, Raj Raghupathy

Journal: Cytokine

PubMed ID: 38359558

Doi: 10.1016/j.cyto.2024.156546

Products & Services: Proteins, Expression, Isolation and Analysis

A recent gibbon ape leukemia virus germline integration in a rodent from New Guinea

Authors: Saba Mottaghinia, Saskia Stenzel, Kyriakos Tsangaras, Nikolas Nikolaidis, Michael Laue, Karin Müller, Henriette Hölscher, Ulrike Löber, Gayle K McEwen, Stephen C Donnellan, Kevin C Rowe, Ken P Aplin, Christine Goffinet, Alex D Greenwood

Journal: Proc Natl Acad Sci U S A

PubMed ID: 38305758

Doi: 10.1073/pnas.2220392121

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A Diversity Covering (DiCo) Plasmodium vivax apical membrane antigen-1 vaccine adjuvanted with RFASE/RSL10 yields high levels of growth-inhibitory antibodies

Authors: Bart W Faber, Lee M Yeoh, Liriye Kurtovic, Wim E M Mol, Martin Poelert, Elly Smits, Roberto Rodriguez Garcia, Marjolein Mandalawi-Van der Eijk, Nicole van der Werff, Annemarie Voorberg-van der Wel, Edmond J Remarque, James G Beeson, Clemens H M Kocken

Journal: Vaccine

PubMed ID: 38365484

Doi: 10.1016/j.vaccine.2024.02.029

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Cloning of three epsilon-class glutathione -transferase genes from (Graeser) (Lepidoptera: Notodontidae) and their response to tannic acid

Authors: Ling Zhang, Huizhen Tu, Fang Tang

Journal: Bull Entomol Res

PubMed ID: 38327098

Doi: 10.1017/S0007485323000718

Products & Services: Molecular Biology Reagents

Nucleocapsid protein-specific monoclonal antibodies protect mice against Crimean-Congo hemorrhagic fever virus

Authors: Aura R Garrison, Vanessa Moresco, Xiankun Zeng, Curtis R Cline, Michael D Ward, Keersten M Ricks, Scott P Olschner, Lisa H Cazares, Elif Karaaslan, Collin J Fitzpatrick, Éric Bergeron, Scott D Pegan, Joseph W Golden

Journal: Nat Commun

PubMed ID: 38409240

Doi: 10.1038/s41467-024-46110-4

Products & Services: Molecular Biology Reagents

Oral administration of a recombinant modified RBD antigen of SARS-CoV-2 as a possible immunostimulant for the care of COVID-19

Authors: Norma A Valdez-Cruz, Diego Rosiles-Becerril, Constanza E Martínez-Olivares, Enrique García-Hernández, Laura Cobos-Marín, Daniel Garzón, Francisco E López-Salas, Guadalupe Zavala, Axel Luviano, Alejandro Olvera, Alejandro Alagón, Octavio T Ramírez, Mauricio A Trujillo-Roldán

Journal: Microb Cell Fact

PubMed ID: 38321489

Doi: 10.1186/s12934-024-02320-5

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Direct observation of autoubiquitination for an integral membrane ubiquitin ligase in ERAD

Authors: Basila Moochickal Assainar, Kaushik Ragunathan, Ryan D Baldridge

Journal: Nat Commun

PubMed ID: 38351109

Doi: 10.1038/s41467-024-45541-3

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Seroprevalence of Anti-SARS-CoV-2 Antibodies in Cats during Five Waves of COVID-19 Epidemic in Thailand and Correlation with Human Outbreaks

Authors: Suporn Thongyuan, Jeeraphong Thanongsaksrikul, Potjanee Srimanote, Wallaya Phongphaew, Piyaporn Eiamcharoen, Naris Thengchaisri, Angela Bosco-Lauth, Nicola Decaro, Rungrueang Yodsheewan

Journal: Animals (Basel)

PubMed ID: 38473145

Doi: 10.3390/ani14050761

Products & Services: Molecular Biology Reagents

Production and Immunogenicity Assessment of LTp50: An -Made Chimeric Antigen Targeting S1- and S2-Epitopes from the SARS-CoV-2/BA5 Spike Protein

Authors: Alejandra Wong-Arce, Omar Gonzalez-Ortega, Andrea Romero-Maldonado, Arleth Miranda-López, Mariano García-Soto, Susan Farfán-Castro, Lourdes Betancourt-Mendiola, Samaporn Teeravechyan, Kanjana Srisutthisamphan, Mauricio Comas-García, Karla I Solís Andrade, Sergio Rosales-Mendoza

Journal: Pharmaceuticals (Basel)

PubMed ID: 38543088

Doi: 10.3390/ph17030302

Products & Services: Proteins, Expression, Isolation and Analysis

A Pseudovirus-Based Neutralization Assay for SARS-CoV-2 Variants: A Rapid, Cost-Effective, BSL-2-Based High-Throughput Assay Useful for Vaccine Immunogenicity Evaluation

Authors: Zhaohui Cai, Raj Kalkeri, Mingzhu Zhu, Shane Cloney-Clark, Benjamin Haner, Mi Wang, Bahar Osman, Dominic Dent, Sheau-Line Feng, Zach Longacre, Greg Glenn, Joyce S Plested

Journal: Microorganisms

PubMed ID: 38543552

Doi: 10.3390/microorganisms12030501

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Characterization of antibodies targeting severe fever with thrombocytopenia syndrome virus glycoprotein Gc

Authors: Kaori Sano, Miyuki Kimura, Akiko Sataka, Hideki Hasegawa, Hideki Tani, Tadaki Suzuki

Journal: Arch Virol

PubMed ID: 38308735

Doi: 10.1007/s00705-024-05968-x

Products & Services: Proteins, Expression, Isolation and Analysis

Nanofibrous MultiDomain Peptide Hydrogels Provide T Cells a 3D, Cytocompatible Environment for Cell Expansion and Antigen-Specific Killing

Authors: Viridiana Leyva-Aranda, Shailbala Singh, Maria J Telesforo, Simon Young, Cassian Yee, Jeffrey D Hartgerink

Journal: ACS Biomater Sci Eng

PubMed ID: 38385283

Doi: 10.1021/acsbiomaterials.3c01617

Products & Services: Proteins, Expression, Isolation and Analysis

GDI2 deletion alleviates neurodegeneration and memory loss in the 5xFAD mice model of Alzheimer's disease

Authors: Meitian Wang, Xiuqing He, Jie Li, Daobin Han, Pan You, Hui Yu, Luwen Wang, Bo Su

Journal: Biochim Biophys Acta Mol Basis Dis

PubMed ID: 38382624

Doi: 10.1016/j.bbadis.2024.167093

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Filamin A Is a Prognostic Serum Biomarker for Differentiating Benign Prostatic Hyperplasia from Prostate Cancer in Caucasian and African American Men

Authors: Nischal Mahaveer Chand, Poornima K Tekumalla, Matt T Rosenberg, Albert Dobi, Amina Ali, Gregory M Miller, Juan J Aristizabal-Henao, Elder Granger, Stephen J Freedland, Mark D Kellogg, Shiv Srivastava, David G McLeod, Niven R Narain, Michael A Kiebish

Journal: Cancers (Basel)

PubMed ID: 38398103

Doi: 10.3390/cancers16040712

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Safety and immunogenicity of CoronaVac in healthy adults: A prospective observational multicenter real-world study in Henan Province, China

Authors: Benchen Rao, Ling Wang, Mengzhao Yang, Hong Luo, Junyi Sun, Shanshuo Liu, Haiyu Wang, Xuemei Wang, Lei Li, Chengyu Yuan, Zujiang Yu, Zhigang Ren

Journal: Virulence

PubMed ID: 38326274

Doi: 10.1080/21505594.2024.2310450

Products & Services: Molecular Biology Reagents

Newcastle disease virus regulates its replication by instigating oxidative stress-driven Sirtuin 7 production

Authors: Kamal Shokeen, Sachin Kumar

Journal: J Gen Virol

PubMed ID: 38376490

Doi: 10.1099/jgv.0.001961

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Progranulin haploinsufficiency mediates cytoplasmic TDP-43 aggregation with lysosomal abnormalities in human microglia

Authors: Wonjae Sung, Min-Young Noh, Minyeop Nahm, Yong Sung Kim, Chang-Seok Ki, Young-Eun Kim, Hee-Jin Kim, Seung Hyun Kim

Journal: J Neuroinflammation

PubMed ID: 38347588

Doi: 10.1186/s12974-024-03039-1

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SOX9 Induces Orbital Fibroblast Activation in Thyroid Eye Disease Via MAPK/ERK1/2 Pathway

Authors: Min Zhou, Bingying Lin, Pengsen Wu, Yu Ke, Siyu Huang, Fan Zhang, Xiangqing Hei, Zhen Mao, Xingyi Li, Pengxia Wan, Tingting Chen, Huasheng Yang, Danping Huang

Journal: Invest Ophthalmol Vis Sci

PubMed ID: 38345552

Doi: 10.1167/iovs.65.2.25

Products & Services: Molecular Biology Reagents

Ultrasound Imaging of Tumor Vascular CD93 with MMRN2 Modified Microbubbles for Immune Microenvironment Prediction

Authors: Dingyi Wang, Changyang Xing, Yuan Liang, Chen Wang, Ping Zhao, Xiao Liang, Qiuyang Li, Lijun Yuan

Journal: Adv Mater

PubMed ID: 38270289

Doi: 10.1002/adma.202310421

Products & Services: Molecular Biology Reagents

Unveiling the Dynamic Self-Assembly of a Recombinant Dragline-Silk-Mimicking Protein

Authors: Dongqing Wu, Anamaria Koscic, Sonja Schneider, Romeo C A Dubini, Diana C Rodriguez Camargo, Sabine Schneider, Petra Rovó

Journal: Biomacromolecules

PubMed ID: 38343096

Doi: 10.1021/acs.biomac.3c01239

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Development of a live-attenuated chimeric vaccine against the emerging Usutu virus

Authors: Zheng-Jian Wang, Rong-Rong Zhang, Mei Wu, Hui Zhao, Xiao-Feng Li, Qing Ye, Cheng-Feng Qin

Journal: Vaccine

PubMed ID: 38310016

Doi: 10.1016/j.vaccine.2024.01.077

Products & Services: Proteins, Expression, Isolation and Analysis

Ultrasound-mediated gene delivery specifically targets liver sinusoidal endothelial cells for sustained FVIII expression in hemophilia A mice

Authors: Savannah M Lawton, Megan A Manson, Meng-Ni Fan, Ting-Yen Chao, Chun-Yu Chen, Peter Kim, Carley Campbell, Xiaohe Cai, Amber Vander Kooi, Carol H Miao

Journal: Mol Ther

PubMed ID: 38341614

Doi: 10.1016/j.ymthe.2024.02.010

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of Candidate Expansin Genes Associated with Seed Weight in Pomegranate ( L)

Authors: Chunyan Liu, Haoyu Zhao, Jiyu Li, Zhen Cao, Bo Deng, Xin Liu, Gaihua Qin

Journal: Genes (Basel)

PubMed ID: 38397202

Doi: 10.3390/genes15020212

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Cross-Phosphorylation between AgrC Histidine Kinase and the Noncognate Response Regulator Lmo1172 in under Benzalkonium Chloride Stress

Authors: Tao Yu, Xiaojie Jiang, Xiaobo Xu, Ping Xu, Shuxing Qiu, Junlei Yin, David P Hamilton, Xiaobing Jiang

Journal: Microorganisms

PubMed ID: 38399796

Doi: 10.3390/microorganisms12020392

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Poly-γ-glutamylation of biomolecules

Authors: Ghader Bashiri, Esther M M Bulloch, William R Bramley, Madison Davidson, Stephanie M Stuteley, Paul G Young, Paul W R Harris, Muhammad S H Naqvi, Martin J Middleditch, Michael Schmitz, Wei-Chen Chang, Edward N Baker, Christopher J Squire

Journal: Nat Commun

PubMed ID: 38346985

Doi: 10.1038/s41467-024-45632-1

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Single dose of a recombinant vesicular stomatitis virus-based vaccine elicits robust and durable neutralizing antibody response against Hantaan virus

Authors: Hui Zhang, He Liu , Jing Wei , Yamei Dang , Yuan Wang , Qiqi Yang , Liang Zhang , Chuantao Ye , Bin Wang , Xiaolei Jin , Linfeng Cheng , Hongwei Ma , Yangchao Dong , Yinghui Li , Yinlan Bai , Xin Lv , Yingfeng Lei , Zhikai Xu , Wei Ye , Fanglin Zhang

Journal: NPJ Vaccines .

PubMed ID: 38341504

Doi: 10.1038/s41541-024-00814-2

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An Enzyme-Cleavable Solubilizing-Tag Facilitates the Chemical Synthesis of Mirror-Image Protein

Authors: Yupeng Zheng, Baochang Zhang , Wei-Wei Shi, Xiangyu Deng, Tong-Yue Wang, Dongyang Han, Yuxiang Ren, Ziyi Yang, Yong-Kang Zhou, Jian Kuang, Zhi-Wen Wang, Shan Tang, Ji-Shen Zheng

Journal: Angew Chem Int Ed Engl .

PubMed ID: 38326236

Doi: 10.1002/ange.202318897

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ECSIT facilitates memory CD8+ T cell development by mediating fumarate synthesis during viral infection and tumorigenesis

Authors: Yongbing Yang , Yanan Wang , Zhongcheng Wang , Huanyu Yan , Yi Gong , Yingchao Hu , Yuying Jiang , Shuang Wen , Feifei Xu , Bingwei Wang , Fiachra Humphries , Yun Chen , Xi Wang , Shuo Yang

Journal: Nat Cell Biol .

PubMed ID: 38326554

Doi: 10.1038/s41556-024-01351-9

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Unveiling the structural mechanisms of nonpeptide ligand recognition and activation in human chemokine receptor CCR8

Authors: Shan Jiang , Xi Lin , Lijie Wu , Ling Wang , Yiran Wu , Ziyi Xu , Fei Xu

Journal: Sci Adv .

PubMed ID: 38306437

Doi: 10.1126/sciadv.adj7500

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Integrating network pharmacology and experimental models to identify notoginsenoside R1 ameliorates atherosclerosis by inhibiting macrophage NLRP3 inflammasome activation

Authors: Jingyue Yu, Jinyu Hu, Margaret Baldini, Huan Lei, Lei Li, Shanshan Luo, Jielian Wu, Xupin Liu, Dan Shan, Yanfei Xie, Haihong Fang, Jun Yu

Journal: J Nat Med

PubMed ID: 38409483

Doi: 10.1007/s11418-023-01776-w

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Membrane-Associated Ubiquitin Ligase RING Finger Protein 152 Orchestrates Melanogenesis via Tyrosinase Ubiquitination

Authors: Ryota Ueda, Rina Hashimoto, Yuki Fujii, José C J M D S Menezes, Hirotaka Takahashi, Hiroyuki Takeda, Tatsuya Sawasaki, Tomonori Motokawa, Kenzo Tokunaga, Hideaki Fujita

Journal: Membranes (Basel)

PubMed ID: 38392670

Doi: 10.3390/membranes14020043

Maternal Phlorizin Intake Protects Offspring from Maternal Obesity-Induced Metabolic Disorders in Mice via Targeting Gut Microbiota to Activate the SCFA-GPR43 Pathway

Authors: Xueran Mei, Yi Li, Xiaoyu Zhang, Xiwen Zhai, Yi Yang, Zhengjuan Li, Liping Li

Journal: J Agric Food Chem

PubMed ID: 38349207

Doi: 10.1021/acs.jafc.3c06370

Products & Services: Proteins, Expression, Isolation and Analysis

Targeting deoxynivalenol for degradation by a chimeric manganese peroxidase/glutathione system

Authors: Xiaoyun Su, Shuai Wang, Xiaolu Wang, Wangli Ji, Honglian Zhang, Tao Tu, Nina Hakulinen, Huiying Luo, Wei Zhang, Huoqing Huang

Journal: Ecotoxicol Environ Saf