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Structures of complete HIV-1 TAR RNA portray a dynamic platform poised for protein binding and structural remodeling

Authors: Charles Bou-Nader, Katie A Link, Krishna C Suddala, Jay R Knutson, Jinwei Zhang

Journal: Nature Communications

PubMed ID: 40050622

Doi: 10.1038/s41467-025-57519-w

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Simultaneous CRISPR screening and spatial transcriptomics reveal intracellular, intercellular, and functional transcriptional circuits

Authors: Loϊc Binan, Aiping Jiang, Serwah A Danquah, Vera Valakh, Brooke Simonton, Jon Bezney, Robert T Manguso, Kathleen B Yates, Ralda Nehme, Brian Cleary, Samouil L Farhi

Journal: Cell

PubMed ID: 40081369

Doi: 10.1016/j.cell.2025.02.012

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Bacterial Hachiman complex executes DNA cleavage for antiphage defense

Authors: Yongqing Cui, Zhikang Dai, Yufei Ouyang, Chunyang Fu, Yanjing Wang, Xueting Chen, Kaiyue Yang, Shuyue Zheng, Wenwen Wang, Pan Tao, Zeyuan Guan, Tingting Zou

Journal: Nature Communications

PubMed ID: 40097437

Doi: 10.1038/s41467-025-57851-1

Structural basis of gap-filling DNA synthesis in the nucleosome by DNA Polymerase β

Authors: Tyler M Weaver, Benjamin J Ryan, Spencer H Thompson, Adil S Hussen, Jonah J Spencer, Zhen Xu, Nicholas J Schnicker, Bret D Freudenthal

Journal: Nature Communications

PubMed ID: 40097433

Doi: 10.1038/s41467-025-57915-2

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Structural dynamics of DNA unwinding by a replicative helicase

Authors: Taha Shahid, Ammar U Danazumi, Muhammad Tehseen, Lubna Alhudhali, Alice R Clark, Christos G Savva, Samir M Hamdan, Alfredo De Biasio

Journal: Nature

PubMed ID: 40108462

Doi: 10.1038/s41586-025-08766-w

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Plant essential oil targets TRPV3 for skin renewal and structural mechanism of action

Authors: Yang Li, Xuteng Lu, Xufeng Cheng, Keyu Xia, Junyan Hu, Peiyu Wang, Peiyuan Pang, Bomin Gao, Demeng Sun, Zhuzhen Zhang, Dongdong Li, Zengqin Deng, Changlin Tian, Chang Xie, Jing Yao

Journal: Nature Communications

PubMed ID: 40108208

Doi: 10.1038/s41467-025-58033-9

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Structural recognition and stabilization of tyrosine hydroxylase by the J-domain protein DNAJC12

Authors: Mary Dayne S Tai, Lissette Ochoa, Marte I Flydal, Lorea Velasco-Carneros, Jimena Muntaner, César Santiago, Gloria Gamiz-Arco, Fernando Moro, Kunwar Jung-Kc, David Gil-Cantero, Miguel Marcilla, Juha P Kallio, Arturo Muga, José María Valpuesta, Jorge Cuéllar, Aurora Martinez

Journal: Nature Communications

PubMed ID: 40113792

Doi: 10.1038/s41467-025-57733-6

Resilient Membranized Coacervates Formed through Spontaneous Wrapping of Heat-Destabilized Lipid Bilayers around Coacervate Droplets

Authors: Sadaf Javed, Evan Spruijt

Journal: Advanced Science

PubMed ID: 40116289

Doi: 10.1002/advs.202412312

Mimicry of molecular glues using dual covalent chimeras

Authors: Eden Kapcan, Karolina Krygier, Maya da Luz, Nickolas J Serniuck, Ali Zhang, Jonathan Bramson, Anthony F Rullo

Journal: Nature Communications

PubMed ID: 40128528

Doi: 10.1038/s41467-025-58083-z

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Conformational reorganization and phase separation drive hyper-editing of ADR-2-ADBP-1 complex

Authors: Jianqiang Mu, Cang Wu, Kaiming Xu, Xingang Liu, Yajuan Fu, Zhen Zhang, Jingwei Yu, Chenyang Xue, Zi Wang, Xinmeng Chen, Yanhong Chen, Guangshuo Ou, Zhongmin Liu

Journal: Nucleic Acids Res

PubMed ID: 40037706

Doi: 10.1093/nar/gkaf148

SUMO4 promotes SUMO deconjugation required for DNA double-strand-break repair

Authors: Alexander J Garvin, Alexander J Lanz, George E Ronson, Matthew J W Mackintosh, Katarzyna Starowicz, Alexandra K Walker, Yara Aghabi, Hannah MacKay, Ruth M Densham, Jai S Bhachoo, Aneika C Leney, Joanna R Morris

Journal: Mol Cell

PubMed ID: 40054443

Doi: 10.1016/j.molcel.2025.02.004

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The OsIAA3-OsARF16-OsBUL1 auxin signaling module regulates grain size in rice

Authors: Fengjun Xian, Shuya Liu, Jishuai Huang, Bin Xie, Lin Zhu, Qiannan Zhang, Chen Lv, Yimeng Xu, Xinrong Zhang, Jun Hu

Journal: Plant Physiol

PubMed ID: 40156155

Doi: 10.1093/plphys/kiaf122

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ER nests are specialized ER subdomains in Arabidopsis where peroxisomes and lipid droplets form

Authors: Zachary J Wright , Nathan E Tharp , Bonnie Bartel

Journal: Developmental Cell

Doi: 10.1016/j.devcel.2025.03.005

Products & Services: Gene Synthesis Protein Electrophoresis and Western

Active- and Allosteric-Site Cyclic Peptide Inhibitors of Secreted M. tuberculosis Chorismate Mutase

Authors: Renier H P van Neer, Patricia K Dranchak, Mahesh Aitha, Lijun Liu, Emma K Carlson, Isabella E Jacobsen, Kevin Battaile, Yuhong Fang, Dingyin Tao, Ganesha Rai, Janak Padia, Scott Lovell, Hiroaki Suga, James Inglese

Journal: ACS Infectious Diseases

PubMed ID: 39903128

Doi: 10.1021/acsinfecdis.4c00798

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Potential role of TRAF2 in pulmonary hypertension in broiler chickens and preparation and specificity analysis of its polyclonal antibody

Authors: Wen Peng, Gen Wan, Sufang Cheng, Guyue Li, Liling Liu, Juan Chen, Pei Liu, Xiaoquan Guo, Xiaona Gao, Gaofeng Cai, Zhanhong Zheng, Ping Liu

Journal: Int J Biol Macromol

PubMed ID: 39798767

Doi: doi.org/10.1016/j.ijbiomac.2025.139741

Products & Services: Protein Electrophoresis and Western

A coronavirus assembly inhibitor that targets the viral membrane protein

Authors: Manon Laporte; Dirk Jochmans; Doroth e Bardiot; Lowiese Desmarets; Oliver J. Debski-Antoniak; Giulia Mizzon; Rana Abdelnabi; Pieter Leyssen; Winston Chiu; Zhikuan Zhang; Norimichi Nomura; Sandro Boland; Umeharu Ohto; Yannick Stahl; Jurgen Wuyts; Steven De Jonghe; Annelies Stevaert; Martijn J. van Hemert; Brenda W. Bontes; Patrick Wanningen; G. J. Mirjam Groenewold; Aneta Zegar; Katarzyna Owczarek; Sanjata Joshi; Mohamed Koukni; Philippe Arzel; Hugo Klaassen; Jean-Christophe Vanherck; Ilse Vandecaetsbeek; Niels Cremers; Kim Donckers; Thibault Francken; Tina Van Buyten; Jasper Rymenants; Joost Schepers; Krzysztof Pyrc; Rolf Hilgenfeld; Jean Dubuisson; Berend-Jan Bosch; Frank Van Kuppeveld; Cecilia Eydoux; Etienne Decroly; Bruno Canard; Lieve Naesens; Birgit Weynand; Eric J. Snijder; Sandrine Belouzard; Toshiyuki Shimizu; Ralf Bartenschlager; Daniel L. Hurdiss; Arnaud Marchand; Patrick Chaltin; Johan Neyts

Journal: Nature

PubMed ID: 40140569

Doi: 10.1038/s41586-025-08773-x

A Modified Variant of Fasciola hepatica FhSAP-2 (mFhSAP-2) as a Recombinant Vaccine Candidate Induces High-Avidity IgG2c Antibodies and Enhances T Cell Activation in C57BL/6 Mice

Authors: Riseilly Ramos-Nieves; Albersy Armina-Rodriguez; Maria Del Mar Figueroa-Gispert; Ghalib Figueroa-Qui ones; Carlimar Ocasio-Malav ; Ana M. Espino

Journal: Vaccines

PubMed ID: 40432154

Doi: 10.3390/vaccines13050545

A Modified Variant of Fasciola hepatica FhSAP-2 (mFhSAP-2) as a Recombinant Vaccine Candidate Induces High-Avidity IgG2c Antibodies and Enhances T Cell Activation in C57BL/6 Mice

Authors: Riseilly Ramos-Nieves; Albersy Armina-Rodriguez; Maria Del Mar Figueroa-Gispert; Ghalib Figueroa-Qui ones; Carlimar Ocasio-Malav ; Ana M. Espino

Journal: Vaccines

PubMed ID: 40432154

Doi: 10.3390/vaccines13050545

De novo design of a two-step approach targeting Claudin-6 for enhanced drug delivery to solid tumors

Authors: Jiayao Yan; Liqing Zhong; Xiaotong Chen; Lin Li; Fangcen Liu; Lei Lei; Mengchao An; Xiao Wei; Ying Wang; Tianran Chen; Jingyi Guo; Jie Shao; Xiaoxiao Yu; Yingjie Zhao; Rutian Li; Qin Liu; Baorui Liu

Journal: Journal of translational medicine

PubMed ID: 41267074

Doi: 10.1186/s12967-025-07316-2

De novo design of a two-step approach targeting Claudin-6 for enhanced drug delivery to solid tumors

Journal: Journal of translational medicine

PubMed ID: 41267074

Doi: 10.1186/s12967-025-07316-2

Enhanced SIRT3 expression restores mitochondrial quality control mechanism to reverse osteogenic impairment in type 2 diabetes mellitus

Authors: Yansi Xian, Bin Liu, Tao Shen, Lin Yang, Rui Peng, Hongdou Shen, Xueying An, Yutian Wang, Yu Ben, Qing Jiang, Baosheng Guo

Journal: Bone Res

PubMed ID: 40025004

Doi: 10.1038/s41413-024-00399-5

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Structure-Guided Development of Chemically Tailored Peptide Binders of RNF43/ZNRF3 to Enable Versatile Design of Membrane Protein-Targeting PROTACs

Authors: Jibin Cui , Qingyun Zheng , Yicheng Weng , Xiaoguo Zhai , Zhen Su , Yunxiang Du , Xiaoxiong Wei , Yuanyuan Yu , Qian Qu , Man Pan

Journal: Analytical Chemistry

PubMed ID: 40000409

Doi: doi.org/10.1002/anie.202501488

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Rational Design Assisted by Evolutionary Engineering Allows (De)Construction and Optimization of Complex Phenotypes in Pseudomonas putida KT2440

Authors: Blas Blázquez, Juan Nogales

Journal: Microbial biotechnology

PubMed ID: 40126873

Doi: 10.1111/1751-7915.70132

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Structural basis for the allosteric activation of Lon by the heat shock protein LarA

Authors: Hsiu-Jung Wang, Yun-Erh Kuan, Meng-Ru Ho, Chung-I Chang

Journal: Nature Communications

PubMed ID: 40044692

Doi: 10.1038/s41467-025-57482-6

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Integration of multi-omics data accelerates molecular analysis of common wheat traits

Authors: Ning Zhang, Li Tang, Songgang Li, Lu Liu, Mengjuan Gao, Sisheng Wang, Daiying Chen, Yichao Zhao, Ruiqing Zheng, Armin Soleymaniniya, Lingran Zhang, Wenkang Wang, Xia Yang, Yan Ren, Congwei Sun, Mathias Wilhelm, Daowen Wang, Min Li, Feng Chen

Journal: Nature Communications

PubMed ID: 40038279

Doi: 10.1038/s41467-025-57550-x

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Immunomodulatory role of the stem cell circadian clock in muscle repair

Authors: Pei Zhu, Eric M Pfrender, Adam W T Steffeck, Colleen R Reczek, Yalu Zhou, Abhishek Vijay Thakkar, Neha R Gupta, Ariana Kupai, Amber Willbanks, Richard L Lieber, Ishan Roy, Navdeep S Chandel, Clara B Peek

Journal: SCIENCE ADVANCES

PubMed ID: 40043110

Doi: 10.1126/sciadv.adq8538

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Epstein-Barr virus infection promotes T cell dysregulation in a humanized mouse model of multiple sclerosis

Authors: Jessica R Allanach, Naomi M Fettig, Blair K Hardman, Ariel R Rosen, Vina Fan, Cynthia Chung, Erin J Goldberg, Zachary J Morse, Iryna Shanina, Galina Vorobeychik, Lisa C Osborne, Marc S Horwitz

Journal: SCIENCE ADVANCES

PubMed ID: 40043135

Doi: 10.1126/sciadv.adu5110

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Elevated NAD+ drives Sir2A-mediated GCβ deacetylation and OES localization for Plasmodium ookinete gliding and mosquito infection

Authors: Yang Shi, Lin Wan, Mengmeng Jiao, Chuan-Qi Zhong, Huiting Cui, Jing Yuan

Journal: Nature Communications

PubMed ID: 40050296

Doi: 10.1038/s41467-025-57517-y

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Enhancing Prime Editing Efficiency Through Modulation of Methylation on the Newly Synthesized DNA Strand and Prolonged Expression

Authors: Xiaosong Han, Xianghua Xu, Youcai Xiong, Guangxing Zhao, Ruigao He, Yinyu Su, Sheng Li, Changzhi Zhao, Xiaoning Xi, Yunxia Zhao, Xuewen Xu, Shengsong Xie, Heng Wang, Xinyun Li, Shuhong Zhao, Jinxue Ruan

Journal: Advanced Science

PubMed ID: 40051369

Doi: 10.1002/advs.202417790

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Soft-matter-induced orderings in a solid-state van der Waals heterostructure

Authors: Kai Zhao, Baojuan Dong, Yuang Wang, Xiaoxue Fan, Qi Wang, Zhiren Xiong, Jing Zhang, Jinkun He, Kaining Yang, Minru Qi, Chengbing Qin, Tongyao Zhang, Maolin Chen, Hanwen Wang, Jianqi Huang, Kai Liu, Hanwei Huang, Kenji Watanabe, Takashi Taniguchi, Yaning Wang, Xixiang Zhang, Juehan Yang, Zhenwen Huang, Yongjun Li, Zhongming Wei, Jing Zhang, Shuoxing Jiang, Zheng Vitto Han, Funan Liu

Journal: Nature Communications

PubMed ID: 40064923

Doi: 10.1038/s41467-025-57690-0

A globular protein exhibits rare phase behavior and forms chemically regulated orthogonal condensates in cells

Authors: Jinglei Nie, Xinyi Zhang, Zhijuan Hu, Wei Wang, Martin A Schroer, Jie Ren, Dmitri Svergun, Anyang Chen, Peiguo Yang, An-Ping Zeng

Journal: Nature Communications

PubMed ID: 40069234

Doi: 10.1038/s41467-025-57886-4

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Overlapping and separable activities of BRA-2 and HIM-17 promote occurrence and regulation of pairing and synapsis during Caenorhabditis elegans meiosis

Authors: Jitka Blazickova, Shalini Trivedi, Richard Bowman, Sowmya Sivakumar Geetha, Silma Subah, Michelle Scuzzarella, Alexander Chang, Uma R Chandran, Judith L Yanowitz, Sarit Smolikove, Verena Jantsch, Monique Zetka, Nicola Silva

Journal: Nature Communications

PubMed ID: 40082424

Doi: 10.1038/s41467-025-57862-y

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Cryo-EM Analysis of a Tri-Heme Cytochrome-Associated RC-LH1 Complex from the Marine Photoheterotrophic Bacterium Dinoroseobacter Shibae

Authors: Weiwei Wang, Yanting Liu, Jiayi Gu, Shaoya An, Cheng Ma, Haichun Gao, Nianzhi Jiao, Jian-Ren Shen, John Thomas Beatty, Michal Koblížek, Xing Zhang, Qiang Zheng, Jing-Hua Chen

Journal: Advanced Science

PubMed ID: 40112203

Doi: 10.1002/advs.202413456

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Selective promotion of sensory innervation-mediated immunoregulation for tissue repair

Authors: Kaicheng Xu, Kaile Wu, Liang Chen, Yubin Zhao, Hengyuan Li, Nong Lin, Zhaoming Ye, Jianbin Xu, Donghua Huang, Xin Huang

Journal: SCIENCE ADVANCES

PubMed ID: 40117376

Doi: 10.1126/sciadv.ads9581

Functional and antigenic landscape of the Nipah virus receptor-binding protein

Authors: Brendan B Larsen, Teagan McMahon, Jack T Brown, Zhaoqian Wang, Caelan E Radford, James E Crowe Jr, David Veesler, Jesse D Bloom

Journal: Cell

PubMed ID: 38659959

Doi: 10.1101/2024.04.17.589977

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Structural mechanisms underlying the modulation of CXCR4 by diverse small-molecule antagonists

Authors: Xiaohong Sang, Haizhan Jiao, Qian Meng, Xiong Fang, Qi Pan, Jiao Zhou, Tingli Qian, Wanqin Zhang, Yan Xu, Jing An, Ziwei Huang, Hongli Hu

Journal: Proceedings of the National Academy of Sciences of the United States of America

PubMed ID: 40063796

Doi: 10.1073/pnas.2425795122

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Large Library Docking for Polypharmacology

Authors: Yujin Wu; Seth Vigneron; Joao Braz; Karthik Srinivasan; Elissa A. Fink; Xi-Ping Huang; Xinyu Xu; Harald Huebner; Joseph Y. Kim; Jing Wang; Tara Pfeiffer; Kensuke Sakamoto; Dmytro S. Radchenko; Ramona M. Rodriguiz; Yurii S. Moroz; John J. Irwin; Peter Gmeiner; Christian Billesboelle; Bryan L. Roth; Allan I. Basbaum; Aashish Manglik; William C. Wetsel; Brian K. Shoichet

Journal: Journal of Medicinal Chemistry

PubMed ID: 41712624

Doi: 10.1021/acs.jmedchem.5c03810

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Large Library Docking for Polypharmacology

Journal: Journal of Medicinal Chemistry

PubMed ID: 41712624

Doi: 10.1021/acs.jmedchem.5c03810

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Large Library Docking for Polypharmacology

Journal: Journal of Medicinal Chemistry

PubMed ID: 41712624

Doi: 10.1021/acs.jmedchem.5c03810

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A Modified Variant of Fasciola hepatica FhSAP-2 (mFhSAP-2) as a Recombinant Vaccine Candidate Induces High-Avidity IgG2c Antibodies and Enhances T Cell Activation in C57BL/6 Mice

Authors: Riseilly Ramos-Nieves; Albersy Armina-Rodriguez; Maria Del Mar Figueroa-Gispert; Ghalib Figueroa-Qui ones; Carlimar Ocasio-Malav ; Ana M. Espino

Journal: Vaccines

PubMed ID: 40432154

Doi: 10.3390/vaccines13050545

Design and Binding Affinity of Antisense Peptides for Snake Venom Neutralization

Authors: Ivan Biru ; Tino eba; Marin Mari ; Mario Gabri evi ; Tin Weitner

Journal: Molecules

PubMed ID: 40005213

Doi: 10.3390/molecules30040903

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Design of CoQ10 crops based on evolutionary history

Authors: Jing-Jing Xu, Yuan Lei, Xiao-Fan Zhang, Jian-Xu Li, Qiupeng Lin, Xiang-Dong Wu, Yu-Guo Jiang, Wenyi Zhang, Runtong Qian, Shu-Yi Xiong, Kuo Tan, Yu Jia, Qiang Zhou, Yan Jiang, Hang Fan, Yan-Bo Huang, Ling-Jian Wang, Ji-Yun Liu, Yu Kong, Qing Zhao, Lei Yang, Jinxing Liu, Yong-Hong Hu, Shuai Zhan, Caixia Gao, Xiao-Ya Chen

Journal: Cell

PubMed ID: 39952246

Doi: 10.1016/j.cell.2025.01.023

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Evaluation of Cas13d as a tool for genetic interaction mapping

Authors: Ghanem El Kassem, Jasmine Hillmer, Michael Boettcher

Journal: Nature Communications

PubMed ID: 39952934

Doi: 10.1038/s41467-025-56747-4

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Activation of CAMK2 by pseudokinase PEAK1 represents a targetable pathway in triple negative breast cancer

Authors: Xue Yang, Xiuquan Ma, Tianyue Zhao, David R Croucher, Elizabeth V Nguyen, Kimberley C Clark, Changyuan Hu, Sharissa L Latham, Charles Bayly-Jones, Bao V Nguyen, Srikanth Budnar, Sung-Young Shin, Lan K Nguyen, Thomas R Cotton, Anderly C Chüeh, Terry C C Lim Kam Sian, Margaret M Stratton, Andrew M Ellisdon, Roger J Daly

Journal: Nature Communications

PubMed ID: 39984440

Doi: 10.1038/s41467-025-57046-8

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The TaCLE24b peptide signaling cascade modulates lateral root development and drought tolerance in wheat

Authors: Wen Yang, Man Feng, Kuohai Yu, Jie Cao, Guangxian Cui, Yumei Zhang, Huiru Peng, Yingyin Yao, Zhaorong Hu, Zhongfu Ni, Feng Qin, Fuminori Takahashi, Qixin Sun, Mingming Xin

Journal: Nature Communications

PubMed ID: 40000659

Doi: 10.1038/s41467-025-57291-x

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RH3 enhances antiviral defense by facilitating small RNA loading into Argonaute 2 at endoplasmic reticulum–chloroplast membrane contact sites

Authors: Juan Huang, Juan Du, Yan Liu, Lu Lu, Yanzhuo Xu, Jianfei Shi, Qing Liu, Qi Li, Yang Liu, Yaqiu Chen, Meng Du, Yiming Zhao, Liangxiao Huo, Weiran Wang, Chenxi Ding, Liya Wei, Jianguo Wu, Yao-Wu Yuan, Jinfeng Chen, Ruixi Li, Feng Cui, Xiaoming Zhang

Journal: Nature Communications

PubMed ID: 40000658

Doi: 10.1038/s41467-025-57296-6

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CK2B Induces CD8+ T-Cell Exhaustion through HDAC8-Mediated Epigenetic Reprogramming to Limit the Efficacy of Anti-PD-1 Therapy in Non-Small-Cell Lung Cancer

Authors: Shaochuan Liu, Shiya Ma, Gen Liu, Lingjie Hou, Yong Guan, Liang Liu, Yuan Meng, Wenwen Yu, Ting Liu, Li Zhou, Zhiyong Yuan, Shuju Pang, Siyuan Zhang, Junyi Li, Xiubao Ren, Qian Sun

Journal: Advanced Science

PubMed ID: 40013761

Doi: 10.1002/advs.202411053

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Activation of the bacterial defenseassociated sirtuin system

Authors: Kaixiang Zhu, Kun Shang, Linyue Wang, Xia Yu, Lei Hua, Weihe Zhang, Bo Qin, Jia Wang, Xiaopan Gao, Hongtao Zhu, Sheng Cui

Journal: Communications Biology

PubMed ID: 39994439

Doi: doi.org/10.1038/s42003-025-07743-3

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Structures of HCoV-OC43 HR1 Domain in Complex with Cognate HR2 or Analogue EK1 Peptide

Authors: Xiuxiu He, Huanzhen Liu, Guang Yang, Lei Yan

Journal: Viruses-Basel

PubMed ID: 40143271

Doi: 10.3390/v17030343

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Bioengineered protein nanocarrier facilitating siRNA escape from lysosomes for targeted RNAi therapy in glioblastoma

Authors: Yiliang Jin, Baoli Zhang, Jianru Li, Zhenxi Guo, Chen Zhang, Xuehui Chen, Long Ma, Zhuoran Wang, Haiyin Yang, Yong Li, Yuhua Weng, Yuanyu Huang, Xiyun Yan, Kelong Fan

Journal: SCIENCE ADVANCES

PubMed ID: 39970222

Doi: 10.1126/sciadv.adr9266

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