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Novel Fragment Inhibitors of PYCR1 from Docking-Guided X-ray Crystallography
Authors: Kaylen R Meeks, Juan Ji , Mykola V Protopopov , Olga O Tarkhanova , Yurii S Moroz , John J Tanner
Journal: J Chem Inf Model
PubMed ID: 38411104
Doi: 10.1021/acs.jcim.3c01879
Products & Services: Molecular Biology Reagents   
Quantification of SARS-CoV-2 monoclonal IgG mass fraction by isotope dilution mass spectrometry
Authors: G Martos, M Bedu, R D Josephs, S Westwood, R I Wielgosz
Journal: Anal Bioanal Chem
PubMed ID: 38427100
Doi: 10.1007/s00216-024-05205-z
Products & Services: Catalog Peptides   
Dependency on host vitamin B12 has shaped Mycobacterium tuberculosis Complex evolution
Authors: Elena Campos-Pardos, Santiago Uranga, Ana Picó, Ana Belén Gómez, Jesús Gonzalo-Asensio
Journal: Nat Commun
PubMed ID: 38461302
Doi: 10.1038/s41467-024-46449-8
Products & Services: Gene Synthesis   
Spatial enhancer activation influences inhibitory neuron identity during mouse embryonic development
Authors: Elena Dvoretskova, May C Ho, Volker Kittke, Florian Neuhaus, Ilaria Vitali, Daniel D Lam, Irene Delgado, Chao Feng, Miguel Torres, Juliane Winkelmann, Christian Mayer
Journal: Nat Neurosci
PubMed ID: 38528203
Doi: 10.1038/s41593-024-01611-9
Products & Services: Molecular Biology Reagents   
The Evolution and Application of a Novel DNA Aptamer Targeting Bone Morphogenetic Protein 2 for Bone Regeneration
Authors: Mengping Liu, Andrew B Kinghorn, Lin Wang, Soubhagya K Bhuyan, Simon Chi-Chin Shiu, Julian A Tanner
Journal: Molecules
PubMed ID: 38542880
Doi: 10.3390/molecules29061243
Products & Services: Gene Synthesis   
A pattern recognition receptor interleukin-1 receptor is involved in reproductive immunity in Macrobrachium nipponense ovary
Authors: Haifu Wan, Lei Yu, Xiaodong Cui, Shuai Guo, Shumei Mu, Xianjiang Kang
Journal: Fish Shellfish Immunol
PubMed ID: 38479568
Doi: 10.1016/j.fsi.2024.109481
Products & Services: Recombinant Proteins   
Caspase-2 protects against ferroptotic cell death
Authors: Swati Dawar, Mariana C Benitez, Yoon Lim, Toby A Dite, Jumana M Yousef, Niko Thio, Sylvain Garciaz, Thomas D Jackson, Julia V Milne, Laura F Dagley, Wayne A Phillips, Sharad Kumar, Nicholas J Clemons
Journal: Cell Death Dis
PubMed ID: 38429264
Doi: 10.1038/s41419-024-06560-6
Products & Services: Mutant Libraries   
Genetic fusion of CCL11 to antigens enhances antigenicity in nucleic acid vaccines and eradicates tumor mass through optimizing T-cell response
Authors: Hailong Qi, Zhongjie Sun, Tianle Gao, Yanling Yao, Yu Wang, Weiwei Li, Xudong Wang, Xiaofang Wang, Defang Liu, Jian-Dong Jiang
Journal: Mol Cancer
PubMed ID: 38459592
Doi: 10.1186/s12943-024-01958-4
Bioengineered Hydrogels Recapitulate Fibroblast Heterogeneity in Cancer
Authors: Nicholas Ching Wei Ho, Josephine Yu Yan Yap, Zixuan Zhao, Yunyun Wang, Kanishka Fernando, Constance H Li, Xue Lin Kwang, Hong Sheng Quah, Camille Arcinas, N Gopalakrishna Iyer, Eliza Li Shan Fong
Journal: Adv Sci (Weinh)
PubMed ID: 38493497
Doi: 10.1002/advs.202307129
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Mutational analysis in Corynebacterium stationis MFS transporters for improving nucleotide bioproduction
Authors: Keita Kinose, Keiko Shinoda, Tomoyuki Konishi, Hisashi Kawasaki
Journal: Appl Microbiol Biotechnol
PubMed ID: 38436751
Doi: 10.1007/s00253-024-13080-y
Products & Services: Gene Synthesis   
Small-molecule caspase-1 inhibitor CZL80 terminates refractory status epilepticus via inhibition of glutamatergic transmission
Authors: Fei Wang, Yu Wang, Qing-Yang Zhang, Ke-Yu Hu, Ying-Jie Song, Lin Yang, Fan Fei, Ceng-Lin Xu, Sun-Liang Cui, Ye-Ping Ruan, Yi Wang, Zhong Chen
Journal: Acta Pharmacol Sin
PubMed ID: 38514863
Doi: 10.1038/s41401-024-01257-0
Construction of recombinant pseudorabies virus expressing PCV2 Cap, PCV3 Cap, and IL-4: investigation of their biological characteristics and immunogenicity
Authors: Yanting Yang, Zhiwen Xu, Qian Tao, Lei Xu, Sirui Gu, Yao Huang, Zheyan Liu, Yang Zhang, Jianhua Wen, Siyuan Lai, Ling Zhu
Journal: Front Immunol
PubMed ID: 38571947
Doi: 10.3389/fimmu.2024.1339387
Products & Services: Molecular Biology Reagents   
Expanding the molecular language of protein liquid-liquid phase separation
Authors: Shiv Rekhi, Cristobal Garcia Garcia, Mayur Barai, Azamat Rizuan, Benjamin S Schuster, Kristi L Kiick, Jeetain Mittal
Journal: Nat Chem
PubMed ID: 38553587
Doi: 10.1038/s41557-024-01489-x
Products & Services: Molecular Biology Reagents   
Engineering APOBEC3A deaminase for highly accurate and efficient base editing
Authors: Lei Yang, Yanan Huo, Man Wang, Dan Zhang, Tianai Zhang, Hao Wu, Xichen Rao, Haowei Meng, Shuming Yin, Jiale Mei, Dexin Zhang, Xi Chen, Jia Lv, Meizhen Liu, Yiyun Cheng, Yuting Guan, Bo Feng, Gaojie Song, Chengqi Yi, Mingyao Liu, Fanyi Zeng, Liren Wang, Dali Li
Journal: Nat Chem Biol
PubMed ID: 38553609
Doi: 10.1038/s41589-024-01595-4
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Bacillus cereus cereolysin O induces pyroptosis in an undecapeptide-dependent manner
Authors: Yujian Wang, Jingchang Luo, Xiaolu Guan , Yan Zhao , Li Sun
Journal: Cell Death Discov
PubMed ID: 38458999
Doi: 10.1038/s41420-024-01887-7
The rapid proximity labeling system PhastID identifies ATP6AP1 as an unconventional GEF for Rheb
Authors: Ran Feng, Feng Liu, Ruofei Li, Zhifen Zhou, Zhuoheng Lin, Song Lin, Shengcheng Deng, Yingying Li, Baoting Nong, Ying Xia, Zhiyi Li, Xiaoqin Zhong, Shuhan Yang, Gang Wan, Wenbin Ma, Su Wu, Zhou Songyang
Journal: Cell Research
PubMed ID: 38448650
Doi: 10.1038/s41422-024-00938-z
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Structural analysis of phosphoribosyltransferase-mediated cell wall precursor synthesis in Mycobacterium tuberculosis
Authors: Shan Gao, Fangyu Wu, Sudagar S Gurcha, Sarah M Batt, Gurdyal S Besra, Zihe Rao, Lu Zhang
Journal: Nature
PubMed ID: 38491273
Doi: 10.1038/s41564-024-01643-8
Persistent immune imprinting occurs after vaccination with the COVID-19 XBB.1.5 mRNA booster in humans
Authors: M Alejandra Tortorici, Amin Addetia, Albert J Seo, Jack Brown, Kaiti Sprouse, Jenni Logue, Erica Clark, Nicholas Franko, Helen Chu, David Veesler
Journal: Immunity
PubMed ID: 38490197
Doi: 10.1016/j.immuni.2024.02.016
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Specific protein-RNA interactions are mostly preserved in biomolecular condensates
Authors: Tebbe de Vries, Mihajlo Novakovic, Yinan Ni, Izabela Smok, Clara Inghelram, Maria Bikaki, Chris P Sarnowski, Yaning Han, Leonidas Emmanouilidis, Giacomo Padroni, Alexander Leitner, Frédéric H-T Allain
Journal: SCIENCE ADVANCES
PubMed ID: 38446881
Doi: 10.1126/sciadv.adm7435
Products & Services: PCR Cloning and Subcloning   
A uniquely efficacious type of CFTR corrector with complementary mode of action
Authors: Valentina Marchesin, Lucile Monnier, Peter Blattmann, Florent Chevillard, Christine Kuntz, Camille Forny, Judith Kamper, Rolf Studer, Alexandre Bossu, Eric A Ertel, Oliver Nayler, Christine Brotschi, Jodi T Williams, John Gatfield
Journal: SCIENCE ADVANCES
PubMed ID: 38427726
Doi: 10.1126/sciadv.adk1814
Products & Services: PCR Cloning and Subcloning   
FUS reads histone H3K36me3 to regulate alternative polyadenylation
Authors: Junqi Jia, Haonan Fan, Xinyi Wan, Yuan Fang, Zhuoning Li, Yin Tang, Yanjun Zhang, Jun Huang, Dong Fang
Journal: Nucleic Acids Research
PubMed ID: 38499486
Doi: 10.1093/nar/gkae184
An optimised protocol for the expression and purification of adenovirus core protein VII
Authors: Ajani Athukorala, Karla J Helbig, Brian P McSharry, Jade K Forwood, Subir Sarker
Journal: J Virol Methods
PubMed ID: 38432358
Doi: 10.1016/j.jviromet.2024.114907
Products & Services: Molecular Biology Reagents   
23-Hydroxybetulinic acid attenuates 5-fluorouracil resistance of colorectal cancer by modulating M2 macrophage polarization via STAT6 signaling
Authors: Zeping Fan, Yaru Cui, Lanying Chen, Peng Liu, Wenbin Duan
Journal: Cancer Immunol Immunother
PubMed ID: 38554148
Doi: 10.1007/s00262-024-03662-0
Products & Services: PCR Cloning and Subcloning   
mmu-miR-374b-5p modulated inflammatory factors via downregulation of C/EBP β/NF-κB signaling in Kupffer cells during Echinococcus multilocularis infection
Authors: Guiting Pu, Yanping Li, Tingli Liu, Hong Li, Liqun Wang, Guoliang Chen, Shanling Cao, Hong Yin, Tharheer Oluwashola Amuda, Xiaola Guo, Xuenong Luo
Journal: Parasit Vectors
PubMed ID: 38553755
Doi: 10.1186/s13071-024-06238-0
Products & Services: Molecular Biology Reagents   
Modulation of Primary and Secondary Processes in Tau Fibril Formation by Salt-Induced Dynamics
Authors: Arshad Abdul Vahid, Muhammed Shafeek Oliyantakath Hassan, Allwin Ebenezer Sahayaraj, Ann Teres Babu, Safwa T Kizhakkeduth, Vinesh Vijayan
Journal: ACS Chem Neurosci
PubMed ID: 38433380
Doi: 10.1021/acschemneuro.3c00852
Products & Services: Molecular Biology Reagents   
Knockout and Replacement Gene Surgery to Treat Rhodopsin-Mediated Autosomal Dominant Retinitis Pigmentosa
Authors: Xuehan Sun, Chen Liang, Yangcan Chen, Tongtong Cui, Jiabao Han, Moyu Dai, Ying Zhang, Qi Zhou, Wei Li
Journal: Hum Gene Ther
PubMed ID: 38368562
Doi: 10.1089/hum.2023.201
Products & Services: Molecular Biology Reagents   
Uncovering the photosystem I assembly pathway in land plants
Authors: Aihong Zhang, Lin Tian, Tong Zhu, Mengyu Li, Mengwei Sun, Ying Fang, Yi Zhang, Congming Lu
Journal: Nat Plants
PubMed ID: 38503963
Doi: 10.1038/s41477-024-01658-3
Products & Services: Catalog Peptides   
Absence of specific autoantibodies in patients with narcolepsy type 1 as indicated by an unbiased random peptide-displayed phage screening
Authors: Thi-Tuyet Trinh Tran, Thi-Hong Nhung Nguyen, Yves Dauvilliers, Roland Liblau, Xuan-Hung Nguyen
Journal: PLoS ONE
PubMed ID: 38442093
Doi: 10.1371/journal.pone.0297625
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A new trivalent recombinant protein for type 2 diabetes mellitus with oral delivery potential: design, expression, and experimental validation
Authors: Maryam Ehsasatvatan, Bahram Baghban Kohnehrouz
Journal: J Biomol Struct Dyn
PubMed ID: 38468545
Doi: 10.1080/07391102.2024.2329290
Products & Services: Molecular Biology Reagents   
Bactericera cockerelli Picorna-like Virus and Three New Viruses Found Circulating in Populations of Potato/Tomato Psyllids ()
Authors: Jennifer Dahan, Gardenia E Orellana, Kaleigh B Wald, Erik J Wenninger, W Rodney Cooper, Alexander V Karasev
Journal: Viruses
PubMed ID: 38543780
Doi: 10.3390/v16030415
Products & Services: PCR Cloning and Subcloning   
Rational Design of Key Enzymes to Efficiently Synthesize Phycocyanobilin in
Authors: Ziwei Wang, Jingwen Zhou, Jianghua Li, Guocheng Du, Jian Chen, Xinrui Zhao
Journal: Biomolecules
PubMed ID: 38540721
Doi: 10.3390/biom14030301
Continuous evolution of compact protein degradation tags regulated by selective molecular glues
Authors: Jaron A M Mercer, Stephan J DeCarlo, Shourya S Roy Burman, Vedagopuram Sreekanth, Andrew T Nelson, Moritz Hunkeler, Peter J Chen, Katherine A Donovan, Praveen Kokkonda, Praveen K Tiwari, Veronika M Shoba, Arghya Deb, Amit Choudhary, Eric S Fischer, David R Liu
Journal: Science
PubMed ID: 38484051
Doi: 10.1126/science.adk4422
Long-term antigen-specific immune response by an oncolytic adenovirus encoding SP-SA-E7-4-1BBL in HPV-16 cancer model
Authors: Alejandra G Martinez-Perez, Rodolfo Garza-Morales, Maria de J Loera-Arias, Sheila A Villa-Cedillo, Aracely Garcia-Garcia, Humberto Rodriguez-Rocha, Orlando E Flores-Maldonado, Jesus Valdes, Jose J Perez-Trujillo, Odila Saucedo-Cardenas
Journal: Mol Biol Rep
PubMed ID: 38460043
Doi: 10.1007/s11033-024-09303-0
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Characterization of Transthyretin Mutation G47V Associated with Hereditary Cardiac Amyloidosis
Authors: Xiaopeng He, Mengdie Wang, Jialu Sun, Zhengyang Yu, Xinyang Hu, Yu Liu, Xiaoping Lin
Journal: Cardiology
PubMed ID: 38437799
Doi: 10.1159/000538081
Products & Services: Molecular Biology Reagents   
ATX1 and HUB1/2 promote recruitment of the transcription elongation factor VIP2 to modulate the floral transition in Arabidopsis
Authors: Qianqian Lu, Wenwen Shi, Fei Zhang, Yong Ding
Journal: Plant J
PubMed ID: 38446797
Doi: 10.1111/tpj.16707
Products & Services: Catalog Antibody   
Self-adaptive pyroptosis-responsive nanoliposomes block pyroptosis in autoimmune inflammatory diseases
Authors: Kaiwang Xu, Huang Yang, Jinghua Fang, Kaijie Qiu, Haotian Shen, Guanrui Huang, Qiangqiang Zheng, Canlong Wang, Tengjing Xu, Xinning Yu, Jiajie Wang, Yunting Lin, Jiacheng Dai, Yuting Zhong, Hongyun Song, Sunan Zhu, Siheng Wang, Zhuxing Zhou, Guang Yang, Zhengwei Mao, Zongyou Pan, Xuesong Dai
Journal: Bioactive Materials
PubMed ID: 38496034
Doi: 10.1016/j.bioactmat.2024.02.022
Products & Services: Bacterial Expression   Mammalian Expression   
Structural basis of U12-type intron engagement by the fully assembled human minor spliceosome
Authors: Rui Bai, Meng Yuan, Pu Zhang, Ting Luo, Yigong Shi, Ruixue Wan
Journal: Science
PubMed ID: 38484052
Doi: 10.1126/science.adn7272
Products & Services: Gene Synthesis   
An intein-based biosensor to measure protein stability in vivo
Authors: Ahyun Son, John S Smetana, Scott Horowitz , Christopher W Lennon
Journal: Protein Sci
PubMed ID: 38380775
Doi: 10.1002/pro.4925
Products & Services: Gene Synthesis   
MIWI N-terminal arginines orchestrate generation of functional pachytene piRNAs and spermiogenesis 
Authors: Nicholas Vrettos, Jan Oppelt, Ansgar Zoch, Paraskevi Sgourdou, Haruka Yoshida, Brian Song, Ryan Fink, Dónal O'Carroll, Zissimos Mourelatos 1
Journal: Nucleic Acids Research
PubMed ID: 38520410
Doi: 10.1093/nar/gkae193
Products & Services: Peptide Synthesis   
Interferon-γ in the tumor microenvironment promotes the expression of B7H4 in colorectal cancer cells, thereby inhibiting cytotoxic T cells
Authors: Zhi-Liang Jing, Guang-Long Liu, Na Zhou, Dong-Yan Xu, Na Feng, Yan Lei, Li-Li Ma, Min-Shan Tang, Gui-Hui Tong, Na Tang, Yong-Jian Deng
Journal: Nature
PubMed ID: 38480774
Doi: 10.1038/s41598-024-56681-3
Products & Services: Polyclonal Antibody Services   
Aging-induced tRNAGlu-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization
Authors: Dingfeng Li, Xinyi Gao, Xiaolin Ma, Ming Wang, Chuandong Cheng, Tian Xue, Feng Gao, Yong Shen, Juan Zhang, Qiang Liu
Journal: Cell Metab
PubMed ID: 38458203
Doi: 10.1016/j.cmet.2024.02.011.
Products & Services: Custom DNA/RNA Oligos   
Unveiling a Shield of Hope: A Novel Multiepitope-Based Immunogen for Cross-Serotype Cellular Defense against Dengue Virus
Authors: Nilanshu Manocha, Daphné Laubreton, Xavier Robert, Jacqueline Marvel, Virginie Gueguen-Chaignon, Patrice Gouet, Prashant Kumar, Madhu Khanna
Journal: Vaccines (Basel)
PubMed ID: 38543950
Doi: 10.3390/vaccines12030316
Products & Services: Catalog Peptides   
Effective Gene Therapy for Metachromatic Leukodystrophy Achieved with Minimal Lentiviral Genomic Integrations
Authors: Lucas Tricoli, Sunetra Sase, Julia Hacker, Vi Pham, Sidney Smith, Maxwell Chappell, Laura Breda, Stephanie Hurwitz, Naoto Tanaka, Carlo Castruccio Castracani, Amaliris Guerra, Zhongqi Hou, Lars Schlotawa, Karthikeyan Radhakrishnan, Peter Kurre, Rebecca Ahrens-Nicklas, Laura Adang, Adeline Vanderver, Stefano Rivella
Journal: biorxiv
PubMed ID: 38559013
Doi: 10.1101/2024.03.14.584404
Products & Services: Molecular Biology Reagents   
G-quadruplexes control hepatitis B virus replication by promoting cccDNA transcription and phase separation in hepatocytes
Authors: Guillaume Giraud, Mélanie Rodà, Pélagie Huchon, Maud Michelet, Sarah Maadadi, Daniel Jutzi, Roland Montserret, Marc-David Ruepp, Romain Parent, Christophe Combet, Fabien Zoulim, Barbara Testoni
Journal: Nucleic Acids Res
PubMed ID: 38113270
Doi: 10.1093/nar/gkad1200
Products & Services: Mutagenesis Services   
Occlusal force orchestrates alveolar bone homeostasis via Piezo1 in female mice
Authors: Yiling Yang, Qinggang Dai, Xin Gao, Yanfei Zhu, Mi Ri Chung, Anting Jin, Yuanqi Liu, Xijun Wang, Xiangru Huang, Siyuan Sun, Hongyuan Xu, Jingyi Liu, Lingyong Jiang
Journal: J Bone Miner Res
PubMed ID: 38477783
Doi: 10.1093/jbmr/zjae032
Nintedanib downregulates the profibrotic M2 phenotype in cultured monocyte-derived macrophages obtained from systemic sclerosis patients affected by interstitial lung disease
Authors: Stefano Soldano, Vanessa Smith, Paola Montagna, Emanuele Gotelli, Rosanna Campitiello, Carmen Pizzorni, Sabrina Paolino, Alberto Sulli, Andrea Cere, Maurizio Cutolo
Journal: Arthritis Res Ther
PubMed ID: 38509595
Doi: 10.1186/s13075-024-03308-7
Zoledronic Acid Accelerates ER Stress-Mediated Inflammation by Increasing PDE4B Expression in Bisphosphonate-Related Osteonecrosis of the Jaw
Authors: Qu Xz, Sun Zq, Liu L, Ong Hs
Journal: Appl Biochem Biotechnol
PubMed ID: 38523176
Doi: 10.1007/s12010-024-04859-w
Products & Services: Gene Synthesis   
Structural determination and kinetic analysis of the transketolase from Vibrio vulnificus reveal unexpected cooperative behavior
Authors: Rainier-Numa Georges, Lionel Ballut, Guillaume Octobre, Arnaud Comte, Laurence Hecquet, Franck Charmantray, Bastien Doumèche
Journal: Protein Sci
PubMed ID: 38145310
Doi: 10.1002/pro.4884
Products & Services: Molecular Biology Reagents   
Supra-biological performance of immobilized enzymes enabled by chaperone-like specific non-covalent interactions
Authors: Héctor Sánchez-Morán, Joel L Kaar, Daniel K Schwartz
Journal: Nat Commun
PubMed ID: 38485940
Doi: 10.1038/s41467-024-46719-5
Products & Services: Molecular Biology Reagents   
Tight junction protein cingulin variant is associated with cancer susceptibility by overexpressed IQGAP1 and Rac1-dependent epithelial-mesenchymal transition
Authors: Yi-Ting Huang, Ya-Ting Hsu, Pei-Ying Wu, Yu-Min Yeh, Peng-Chan Lin, Keng-Fu Hsu, Meng-Ru Shen
Journal: J Exp Clin Cancer Res
PubMed ID: 38424547
Doi: 10.1186/s13046-024-02987-z
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