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Down-regulation of SLC14A1 in prostate cancer activates CDK1/CCNB1 and mTOR pathways and promotes tumor progression

Authors: Jianbin Ma, Kaihua Xue, Yifan Jiang, Xinyang Wang, Dalin He, Peng Guo

Journal: Sci Rep

PubMed ID: 38942821

Doi: 10.1038/s41598-024-66020-1

Products & Services: Molecular Biology Reagents

Neutralizing antibodies reveal cryptic vulnerabilities and interdomain crosstalk in the porcine deltacoronavirus spike protein

Authors: Wenjuan Du, Oliver Debski-Antoniak, Dubravka Drabek, Rien van Haperen, Melissa van Dortmondt, Joline van der Lee, Ieva Drulyte, Frank J M van Kuppeveld, Frank Grosveld, Daniel L Hurdiss, Berend-Jan Bosch

Journal: Nat Commun

PubMed ID: 38909062

Doi: 10.1038/s41467-024-49693-0

Products & Services: DNA Sequencing

Anaplastic Lymphoma Kinase signaling stabilizes SLC3A2 expression via MARCH11 to promote neuroblastoma cell growth

Authors: Wei-Yun Lai, Tzu-Po Chuang, Marcus Borenäs, Dan E Lind, Bengt Hallberg, Ruth H Palmer

Journal: Cell Death Differ

PubMed ID: 38858548

Doi: 10.1038/s41418-024-01319-0

Products & Services: Molecular Biology Reagents

Synthetic genomes unveil the effects of synonymous recoding

Authors: Akos Nyerges, Anush Chiappino-Pepe, Bogdan Budnik, Maximilien Baas-Thomas, Regan Flynn, Shirui Yan, Nili Ostrov, Min Liu, Meizhou Wang, Qingmei Zheng, Fangxiang Hu, Kangming Chen, Alexandra Rudolph, Dawn Chen, Jenny Ahn, Owen Spencer, Venkat Ayalavarapu, Angela Tarver, Miranda Harmon-Smith, Matthew Hamilton, Ian Blaby, Yasuo Yoshikuni, Behnoush Hajian, Adeline Jin, Balint Kintses, Monika Szamel, Viktoria Seregi, Yue Shen, Zilong Li, George M Church

Journal: biorxiv

PubMed ID: 38915524

Doi: 10.1101/2024.06.16.599206

Products & Services: Gene Synthesis

GASP: A Pan-Specific Predictor of Family 1 Glycosyltransferase Acceptor Specificity Enabled by a Pipeline for Substrate Feature Generation and Large-Scale Experimental Screening

Authors: David Harding-Larsen, Christian Degnbol Madsen, David Teze, Tiia Kittilä, Mads Rosander Langhorn, Hani Gharabli, Mandy Hobusch, Felipe Mejia Otalvaro, Onur Kırtel, Gonzalo Nahuel Bidart, Stanislav Mazurenko, Evelyn Travnik, Ditte Hededam Welner

Journal: ACS Omega

PubMed ID: 38947828

Doi: 10.1021/acsomega.4c01583

Products & Services: Gene Synthesis

The Human Genetic Differences in the Outcomes of mRNA Vaccination against COVID-19: A Prospective Cohort Study

Authors: Ha-Eun Ryu, Jihyun Yoon, Ja-Eun Choi, Seok-Jae Heo, Kyung-Won Hong, Dong-Hyuk Jung

Journal: Vaccines (Basel)

PubMed ID: 38932355

Doi: 10.3390/vaccines12060626

Products & Services: Molecular Biology Reagents

Population differentiation and dynamics of five pioneer species of Gaultheria from the secondary forests in subtropical China

Authors: Yi-Rong Li, Peter W Fritsch, Gui-Gang Zhao, Xiao-Juan Cheng, Zhao-Li Ding, Lu Lu

Journal: BMC Plant Biol

PubMed ID: 38851686

Doi: 10.1186/s12870-024-05189-z

Products & Services: PCR Cloning and Subcloning

CircSCNN1A inhibits the proliferation, migration and invasion of renal cell carcinoma cells by decreasing CLDN8 expression through miR-590-5p

Authors: Tingting Guo, Wanjuan Xiong, Chong Liu, Li Zhu, Ling Xie

Journal: Genesis

PubMed ID: 38764323

Doi: 10.1002/dvg.23599

Products & Services: Mutant Libraries

N-terminal cysteine acetylation and oxidation patterns may define protein stability

Authors: Karen C Heathcote, Thomas P Keeley, Matti Myllykoski, Malin Lundekvam, Nina McTiernan, Salma Akter, Norma Masson, Peter J Ratcliffe, Thomas Arnesen, Emily Flashman

Journal: Nat Commun

PubMed ID: 38918375

Doi: 10.1038/s41467-024-49489-2

Products & Services: Catalog Peptides

Enabling high-throughput enzyme discovery and engineering with a low-cost, robot-assisted pipeline

Authors: Brenna Norton-Baker, Mackenzie C R Denton, Natasha P Murphy, Benjamin Fram, Samuel Lim, Erika Erickson, Nicholas P Gauthier, Gregg T Beckham

Journal: Sci Rep

PubMed ID: 38914665

Doi: 10.1038/s41598-024-64938-0

Products & Services: Protein and Antibody Isolation

PCNA molecular recognition of different PIP motifs: Role of Tyr211 phosphorylation

Authors: Antonio Ruiz-Albor, Belén Chaves-Arquero, Inés Martín-Barros, Alejandra Guerra-Castellano, Amaia Gonzalez-Magaña, Alain Ibáñez de Opakua, Nekane Merino, Mariola Ferreras-Gutiérrez, Edurne Berra, Irene Díaz-Moreno, Francisco J Blanco

Journal: Int J Biol Macromol

PubMed ID: 38880460

Doi: 10.1016/j.ijbiomac.2024.133187

Products & Services: Protein and Antibody Isolation

In vitro antibody-mediated SARS-CoV-2 infection suppression through human ACE2 receptor blockade

Authors: Priscilla S Redd, Alyssa D Merting, John D Klement, Dakota B Poschel, Dafeng Yang, Kebin Liu

Journal: Immunol Lett

PubMed ID: 38925442

Doi: 10.1016/j.imlet.2024.106887

Products & Services: Protein and Antibody Isolation

Molecular insights into type I interferon suppression and enhanced pathogenicity by species B human adenoviruses B7 and B14

Authors: Drayson Graves, Nikolas Akkerman, Lauren Fulham, Rafe Helwer, Peter Pelka

Journal: MBio

PubMed ID: 38940561

Doi: 10.1128/mbio.01038-24

Products & Services: Protein Electrophoresis and Western

TRIM32 inhibits Venezuelan Equine Encephalitis Virus Infection by targeting a late step in viral entry

Authors: Yifan Xie, Jie Cao, Shuyi Gan, Lingdong Xu, Dongjie Zhang, Suhong Qian, Feng Xu, Qiang Ding, John W Schoggins, Wenchun Fan

Journal: biorxiv

PubMed ID: 38895352

Doi: 10.1101/2024.06.04.597282

Products & Services: Protein and Antibody Isolation

Interleukin-17A educated hepatic stellate cells promote hepatocellular carcinoma occurrence through fibroblast activation protein expression

Authors: Jun-Sheng Ni, Si-Yuan Fu, Zong-Yan Wang, Wen-Bin Ding, Jian Huang, Xing-Gang Guo, Fang-Ming Gu

Journal: J Gene Med

PubMed ID: 38860366

Doi: 10.1002/jgm.3693

Products & Services: Protein Electrophoresis and Western

Evolutionary history and activity towards oligosaccharides and polysaccharides of GH3 glycosidases from an Antarctic marine bacterium

Authors: Alessandro Marchetti, Marco Orlando, Luca Bombardi, Salvatore Fusco, Marco Mangiagalli, Marina Lotti

Journal: Int J Biol Macromol

PubMed ID: 38944065

Doi: 10.1016/j.ijbiomac.2024.133449

Products & Services: Gene Synthesis

Nanopore Identification of L‐, D‐Lactic Acids, D‐Glucose and Gluconic Acid in the Serum of Human and Animals

Authors: Wendong Jia, Yusheng Ouyang, Shanyu Zhang, Panke Zhang, Shuo Huang

Journal: Small Methods

PubMed ID: 38864527

Doi: 10.1002/smtd.202400664

Products & Services: Molecular Biology Reagents

Structural and mechanistic basis for nucleosomal H2AK119 deubiquitination by single-subunit deubiquitinase USP16

Authors: Huasong Ai , Zaozhen He, Zhiheng Deng, Guo-Chao Chu, Qiang Shi, Zebin Tong, Jia-Bin Li , Man Pan , Lei Liu

Journal: Nat Struct Mol Biol

PubMed ID: 38918638

Doi: doi.org/10.1038/s41594-024-01342-2

Products & Services: Codon Optimization

SpRY-mediated screens facilitate functional dissection of non-coding sequences at single-base resolution

Authors: Yao Yao, Zhiwei Zhou, Xiaoling Wang, Zhirui Liu, Yixin Zhai, Xiaolin Chi, Jingyi Du, Liheng Luo, Zhigang Zhao, Xiaoyue Wang, Chaoyou Xue, Shuquan Rao

Journal: Cell Genom

PubMed ID: 38889719

Doi: 10.1016/j.xgen.2024.100583

Products & Services: Synthetic Guide RNA

Control of mitophagy initiation and progression by the TBK1 adaptors NAP1 and SINTBAD

Authors: Elias Adriaenssens, Thanh Ngoc Nguyen, Justyna Sawa-Makarska, Grace Khuu, Martina Schuschnig, Stephen Shoebridge, Marvin Skulsuppaisarn, Emily Maria Watts, Kitti Dora Csalyi, Benjamin Scott Padman, Michael Lazarou, Sascha Martens

Journal: Nat Struct Mol Biol

PubMed ID: 38918639

Doi: 10.1038/s41594-024-01338-y

Products & Services: Gene Synthesis

The ric-8b protein (resistance to inhibitors of cholinesterase 8b) is key to preserving contractile function in the adult heart

Authors: Elena Tsisanova, Muriel Nobles, Sonia Sebastian, Keat-Eng Ng, Alison Thomas, Lee Scott Weinstein, Patricia B Munroe, Andrew Tinker

Journal: J Biol Chem

PubMed ID: 38879012

Doi: 10.1016/j.jbc.2024.107470

Products & Services: Molecular Biology Reagents

Conservation of C4BP-binding Sequence Patterns in Streptococcus pyogenes M and Enn Proteins

Authors: Piotr Kolesiński, Matthew McGowan, Anne Botteaux, Pierre R Smeesters, Partho Ghosh

Journal: J Biol Chem

PubMed ID: 38879009

Doi: 10.1016/j.jbc.2024.107478

Products & Services: Protein and Antibody Isolation

Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes

Authors: Hüsün S Kizilkaya, Kimmie V Sørensen, Jakob S Madsen, Peter Lindquist, Jonathan D Douros, Jette Bork-Jensen, Alessandro Berghella, Peter A Gerlach, Lærke S Gasbjerg, Jacek Mokrosiński, Stephanie A Mowery, Patrick J Knerr, Brian Finan, Jonathan E Campbell, David A D'Alessio, Diego Perez-Tilve, Felix Faas, Signe Mathiasen, Jørgen Rungby, Henrik T Sørensen, Allan Vaag, Jens S Nielsen, Jens-Christian Holm, Jeannet Lauenborg, Peter Damm, Oluf Pedersen, Allan Linneberg, Bolette Hartmann, Jens J Holst, Torben Hansen, Shane C Wright, Volker M Lauschke, Niels Grarup, Alexander S Hauser, Mette M Rosenkilde

Journal: Nat Metab

PubMed ID: 38871982

Doi: 10.1038/s42255-024-01061-4

Products & Services: Molecular Biology Reagents

ATM and ATR gene editing mediated by CRISPR/Cas9 in Chinese Hamster cells

Authors: Junko Maeda , Piyawan Chailapakul , Takamitsu A Kato

Journal: Mutat Res

PubMed ID: 39024734

Doi: 10.1016/j.mrfmmm.2024.111871

Products & Services: CRISPR Plasmids

Plasma proteomics identify biomarkers predicting Parkinson's disease up to 7 years before symptom onset

Authors: Jenny Hällqvist, Michael Bartl, Mohammed Dakna, Sebastian Schade, Paolo Garagnani, Maria-Giulia Bacalini, Chiara Pirazzini, Kailash Bhatia, Sebastian Schreglmann, Mary Xylaki, Sandrina Weber, Marielle Ernst, Maria-Lucia Muntean, Friederike Sixel-Döring, Claudio Franceschi, Ivan Doykov, Justyna Śpiewak, Héloїse Vinette, Claudia Trenkwalder, Wendy E Heywood, Kevin Mills, Brit Mollenhauer

Journal: Nat Commun

PubMed ID: 38890280

Doi: 10.1038/s41467-024-48961-3

Products & Services: Peptide Synthesis

Discovery and Characterization of Two Folded Intermediates for Outer Membrane Protein TolC Biogenesis

Authors: Ayotunde Paul Ikujuni, Rik Dhar, Andres Cordova, Alexander M Bowman, Sarah Noga, Joanna S G Slusky

Journal: J Mol Biol

PubMed ID: 38871177

Doi: 10.1016/j.jmb.2024.168652

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Systematic identification and functional analysis of root meristem growth factors (RGFs) reveals role of PgRGF1 in modulation of root development and ginsenoside production in Panax ginseng

Authors: Weipeng Lian, Linfan Zhang, Chenglin Wang, Shiqi Wu, Shan He, Jinlin Lei, Yonghong Zhang, Lei You, Lanlan Zheng, Xiangyin Luo, Zhengxiu Ye, Ziyao Hu, Guodong Wang, Yun Zhu, Chen Li, Juan Liu

Journal: Int J Biol Macromol

PubMed ID: 38945337

Doi: 10.1016/j.ijbiomac.2024.133446

Products & Services: Gene Synthesis

AGC kinases OXI1 and AGC2-2 regulate camalexin secretion and disease resistance by phosphorylating transporter PDR6

Authors: Juan Han, Chang-Xin Liu, Jian Liu, Cheng-Run Wang, Shun-Chang Wang, Guopeng Miao

Journal: Plant Physiol

PubMed ID: 38535832

Doi: 10.1093/plphys/kiae186

Products & Services: Protein and Antibody Isolation

Seeding activity of human superoxide dismutase 1 aggregates in familial and sporadic amyotrophic lateral sclerosis postmortem neural tissues by real-time quaking-induced conversion

Authors: Justin K. Mielke, Mikael Klingeborn, Eric P. Schultz, Erin L. Markham, Emily D. Reese, Parvez Alam, Ian R. Mackenzie, Cindy V. Ly, Byron Caughey, Neil R. Cashman & Moses J. Leavens

Journal: Acta Neuropathologica

PubMed ID: 38884646

Doi: 10.1007/s00401-024-02752-8

Products & Services: DNA Sequencing

Receptor-like kinase ERECTA negatively regulates anthocyanin accumulation in grape

Authors: Bo Wang, Qianqian Pang, Yunzhi Zhou, Jungui Yang, Ehsan Sadeghnezhad, Yuanxin Cheng, Sihong Zhou, Haifeng Jia

Journal: Plant Sci

PubMed ID: 38942388

Doi: 10.1016/j.plantsci.2024.112172

Products & Services: Gene Synthesis

Structural insights into somatostatin receptor 5 bound with cyclic peptides

Authors: Ying-Ge Li, Xian-Yu Meng, Xiru Yang, Sheng-Long Ling, Pan Shi, Chang-Lin Tian, Fan Yang

Journal: Acta Pharmacol Sin

PubMed ID: 38926478

Doi: 10.1038/s41401-024-01314-8

Products & Services: Protein and Antibody Isolation

Identification, Synthesis, and In Vitro Activities of Antimicrobial Peptide from African Catfish against the Extended-Spectrum Beta-Lactamase (ESBL)-Producing Escherichia coli

Authors: Hedmon Okella , Steven Odongo , Didier Vertommen , Emmanuel Okello

Journal: Pharmaceutics

PubMed ID: 39065546

Doi: 10.3390/pharmaceutics16070850

Products & Services: Peptide Synthesis

A large-scale type I CBASS antiphage screen identifies the phage prohead protease as a key determinant of immune activation and evasion

Authors: Desmond Richmond-Buccola, Samuel J Hobbs, Jasmine M Garcia, Hunter Toyoda, Jingjing Gao, Sichen Shao, Amy S Y Lee, Philip J Kranzusch

Journal: Cell Host Microbe

PubMed ID: 38917809

Doi: 10.1016/j.chom.2024.05.021

Products & Services: Protein and Antibody Isolation

Integrated metabolomics and transcriptomics reveal that HhERF9 positively regulates salt tolerance in Hibiscus hamabo Siebold & Zuccarini

Authors: Longjie Ni, Yu Xu, Zhiquan Wang, Chaoguang Yu, Jianfeng Hua, Yunlong Yin, Huogen Li, Chunsun Gu

Journal: Plant Physiol Biochem

PubMed ID: 38879985

Doi: 10.1016/j.plaphy.2024.108843

Products & Services: Protein and Antibody Isolation

Dissecting the dynamics of SARS-CoV-2 reinfections in blood donors with pauci- or asymptomatic COVID-19 disease course at initial infection

Authors: Alexandra Domnica Hoeggerl, Verena Nunhofer, Lisa Weidner, Wanda Lauth, Georg Zimmermann, Natalie Badstuber, Christoph Grabmer, Orkan Kartal, Christof Jungbauer, Heidrun Neureiter, Nina Held, Tuulia Ortner, Maria Flamm, Jürgen Osterbrink, Eva Rohde, Sandra Laner-Plamberger

Journal: Infect Dis (Lond)

PubMed ID: 38869944

Doi: 10.1080/23744235.2024.2367112

Products & Services: Protein and Antibody Isolation

Detection of avian reovirus (ARV) by ELISA based on recombinant σB, σC and σNS full-length proteins and protein fragments

Authors: Tatiana Reichert Assunção de Matos, Ana Paula Gori Palka, Claudemir de Souza, Stenio Perdigão Fragoso, Daniela Parada Pavoni

Journal: J Med Microbiol

PubMed ID: 38935078

Doi: 10.1099/jmm.0.001836

Products & Services: Gene Synthesis

Human cytomegalovirus deploys molecular mimicry to recruit VPS4A to sites of virus assembly

Authors: Benjamin G Butt, Daniela Fischer, Alison R Rep, Martin Schauflinger, Clarissa Read, Thomas Böck, Manuel Hirner, Frederik Wienen, Stephen C Graham, Jens von Einem

Journal: PLoS Pathog

PubMed ID: 38900818

Doi: 10.1371/journal.ppat.1012300

Products & Services: Protein and Antibody Isolation

Galectin-8 counteracts folic acid-induced acute kidney injury and prevents its transition to fibrosis

Authors: Elisa Perez-Moreno, Tomás Toledo, Pascale Campusano, Sebastián Zuñiga, Lorena Azócar, Teo Feuerhake, Gonzalo P Méndez, Mariana Labarca, Francisca Pérez-Molina, Adely de la Peña, Cristian Herrera-Cid, Pamela Ehrenfeld, Alejandro S Godoy, Alfonso González, Andrea Soza

Journal: Biomed Pharmacother

PubMed ID: 38936192

Doi: 10.1016/j.biopha.2024.116923

Products & Services: Protein and Antibody Isolation

Unveiling of the Co-Infection of Peste des Petits Ruminants Virus and Caprine Enterovirus in Goat Herds with Severe Diarrhea in China

Authors: Qun Zhang, Xuebo Zheng, Fan Zhang, Xuyuan Cui, Naitian Yan, Junying Hu, Yidi Guo, Xinping Wang

Journal: Viruses

PubMed ID: 38932277

Doi: 10.3390/v16060986

Products & Services: Protein and Antibody Isolation

Protein disulfide isomerase is essential for spermatogenesis in mice

Authors: Yaqiong Zhang, Aizhen Yang, Zhenzhen Zhao, Fengwu Chen, Xiaofeng Yan, Yue Han, Depei Wu, Yi Wu

Journal: JCI Insight

PubMed ID: 38912589

Doi: 10.1172/jci.insight.177743

Products & Services: Protein and Antibody Isolation

RBD design increases the functional antibody titers elicited by SARS-CoV-2 spike vaccination

Authors: Thayne H Dickey, Nichole D Salinas, Palak Patel, Sachy Orr-Gonzalez, Tarik Ouahes, Holly McAleese, Brandi L Richardson, Myesha Singleton, Michael Murphy, Brett Eaton, Jennifer L Kwan, Michael R Holbrook, Lynn E Lambert, Niraj H Tolia

Journal: Antiviral Res

PubMed ID: 38901738

Doi: 10.1016/j.antiviral.2024.105937

Products & Services: Protein and Antibody Isolation

Engineered CD147-Deficient THP-1 Impairs Monocytic Myeloid-Derived Suppressor Cell Differentiation but Maintains Antibody-Dependent Cellular Phagocytosis Function for Jurkat T-ALL Cells with Humanized Anti-CD147 Antibody

Authors: Thanathat Pamonsupornwichit, Kanokporn Sornsuwan, On-Anong Juntit, Umpa Yasamut, Nuchjira Takheaw, Watchara Kasinrerk, Phenphichar Wanachantararak, Kanchanok Kodchakorn, Piyarat Nimmanpipug, Nutjeera Intasai, Chatchai Tayapiwatana

Journal: Int J Mol Sci

PubMed ID: 38928332

Doi: 10.3390/ijms25126626

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Three families of CD4-induced antibodies are associated with the capacity of plasma from people living with HIV to mediate ADCC in presence of CD4-mimetics

Authors: Alexandra Tauzin, Lorie Marchitto, Étienne Bélanger, Mehdi Benlarbi, Guillaume Beaudoin-Bussières, Jérémie Prévost, Derek Yang, Ta-Jung Chiu, Hung-Ching Chen, Catherine Bourassa, Halima Medjahed, Marek K Korzeniowski, Suneetha Gottumukkala, William D Tolbert, Jonathan Richard, Amos B Smith, Marzena Pazgier, Andrés Finzi

Journal: medrxiv

PubMed ID: 38883797

Doi: 10.1101/2024.06.02.24308281

Products & Services: Catalog Peptides

Oriented immobilization of nanobodies using SpyCatcher/SpyTag significantly enhances the capacity of affinity chromatography

Authors: Yuxiang Zhang, Yao Zhang, Luyao Zhang, Yongdong Liu

Journal: J Chromatogr A

PubMed ID: 38905946

Doi: 10.1016/j.chroma.2024.465107

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Enhanced Recombinant Protein Expression in Insect Cells by Natural and Recombinant Components of Lepidoptera Hemolymph

Authors: Javier López-Vidal, Susana Martínez-Pulgarín, Diego Martínez-Alonso, Miguel Cid, José M Escribano

Journal: Viruses

PubMed ID: 38932236

Doi: 10.3390/v16060944

Products & Services: Protein and Antibody Isolation

NpeA is a secreted Type IV effector containing an N-WASP-binding short linear motif that promotes niche formation

Authors: Agostina Giménez, Mariela G Del Giudice, Paula V López, Francisco Guaimas, Hugo Sámano-Sánchez, Toby J Gibson, Lucía B Chemes, Carlos O Arregui, Juan E Ugalde, Cecilia Czibener

Journal: MBio

PubMed ID: 38847540

Doi: 10.1128/mbio.00726-24

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A safe and potentiated multi-type HPV L2-E7 nanoparticle vaccine with combined prophylactic and therapeutic activity

Authors: Xueer Zhao, Yueru Zhang, Oscar Trejo-Cerro, Ecem Kaplan, Zhe Li, Femke Albertsboer, Neyla El Hammiri, Filipe Colaço Mariz, Lawrence Banks, Simone Ottonello, Martin Müller

Journal: npj Vaccines

PubMed ID: 38926425

Doi: 10.1038/s41541-024-00914-z

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Estrogen-mediated DNMT1 and DNMT3A recruitment by EZH2 silences miR-570-3p that contributes to papillary thyroid malignancy through DPP4

Authors: Xiarong Hu, Qingyao Ye, HuanQuan Lu, Zhiming Wu, Siyuan Chen, Ruinian Zheng

Journal: Clin Epigenetics

PubMed ID: 38890707

Doi: 10.1186/s13148-024-01685-z

Products & Services: Protein Electrophoresis and Western

Molecular and structural basis of an ATPase-nuclease dual-enzyme anti-phage defense complex

Authors: Qiyin An, Yong Wang, Zhenhua Tian, Jie Han, Jinyue Li, Fumeng Liao, Feiyang Yu, Haiyan Zhao, Yancheng Wen, Heng Zhang & Zengqin Deng