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Enhancing precision medicine: Bispecific antibody-mediated targeted delivery of lipid nanoparticles for potential cancer therapy
Authors: Yue Zhang, Xiaoyan Gu, Lili Huang, Yani Yang, Jun He
Journal: Int J Pharm
PubMed ID: 38467208
Doi: 10.1016/j.ijpharm.2024.123990
Products & Services: Molecular Biology Tools   
Construction by artificial intelligence and immunovalidation of hypoallergenic mite allergen Der f 36 vaccine
Authors: Qiao-Zhi Qin, Jian Tang, Cai-Yun Wang, Zhi-Qiang Xu, Man Tian
Journal: Front Immunol
PubMed ID: 38601166
Doi: 10.3389/fimmu.2024.1325998
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An oncolytic vaccinia virus encoding hyaluronidase reshapes the extracellular matrix to enhance cancer chemotherapy and immunotherapy
Authors: Shibing Wang, Yuxin Li, Chuning Xu, Jie Dong, Jiwu Wei
Journal: J Immunother Cancer
PubMed ID: 38458640
Doi: 10.1136/jitc-2023-008431
Products & Services: Recombinant Proteins   
CAR-engineered lymphocyte persistence is governed by a FAS ligand/FAS auto-regulatory circuit
Authors: Fei Yi, Tal Cohen, Natalie Zimmerman, Friederike Dündar, Paul Zumbo, Razan Eltilib, Erica J Brophy, Hannah Arkin, Judith Feucht, Michael V Gormally, Christopher S Hackett, Korbinian N Kropp, Inaki Etxeberria, Smita S Chandran, Jae H Park, Katharine C Hsu, Michel Sadelain, Doron Betel, Christopher A Klebanoff
Journal: biorxiv
PubMed ID: 38464085
Doi: 10.1101/2024.02.26.582108
Products & Services: Gene Synthesis   
Biochemical and structural analysis of N-myristoyltransferase mediated protein tagging
Authors: Paul Monassa , Frédéric Rivière , Cyril Dian , Frédéric Frottin , Carmela Giglione , Thierry Meinnel
Journal: Methods Enzymol .
PubMed ID: 37230587
Doi: 10.1016/bs.mie.2023.02.016
Products & Services: Peptide Synthesis   
Kinetic and catalytic features of N-myristoyltransferases
Authors: Frédéric Rivière , Paul Monassa , Carmela Giglione , Thierry Meinnel
Journal: Methods Enzymol .
PubMed ID: 37230588
Doi: 10.1016/bs.mie.2023.02.018
Products & Services: Peptide Synthesis   
A next generation peripherally restricted Cavα2δ-1 ligand with inhibitory action on Cav22 channels and utility in neuropathic pain
Authors: Franz Kricek, Christine Ruf, Premji Meghani, Ivana A Souza, Maria A Gandini, Gerald W Zamponi, George Skouteris
Journal: Biomed Pharmacother
PubMed ID: 38531121
Doi: 10.1016/j.biopha.2024.116472
Products & Services: Molecular Biology Reagents   
Oxysterol 25-hydroxycholesterol activation of ferritinophagy inhibits the development of squamous intraepithelial lesion of cervix in HPV-positive patients
Authors: Tianming Wang, Min Gong, Yingfei Lu, Chengcheng Zhao, Ling Ling, Jianquan Chen, Rong Ju
Journal: Cell Death Discov
PubMed ID: 38472192
Doi: 10.1038/s41420-024-01899-3
Influence of Mutations and N-Glycosylation Sites in the Receptor-Binding Domain (RBD) and the Membrane Protein of SARS-CoV-2 Variants of Concern on Antibody Binding in ELISA
Authors: Mandy Schwarze, Daniela Volke, Juan Camilo Rojas Echeverri, Robin Schick, Nicole Lakowa, Thomas Grünewald, Johannes Wolf, Stephan Borte, Markus Scholz, Andor Krizsan, Ralf Hoffmann
Journal: Biology (Basel)
PubMed ID: 38666819
Doi: 10.3390/biology13040207
Study on the Thermal Stability of the Sweet-Tasting Protein Brazzein Based on Its Structure-Sweetness Relationship
Authors: Jingnan Zuo, Wei Zheng, Nian Shi, Rong Song, Fei Han, Chen Yang, Jingwen Li, Chao Peng, Bin Li, Yijie Chen
Journal: J Agric Food Chem
PubMed ID: 38526016
Doi: 10.1021/acs.jafc.3c09616
Products & Services: Gene Synthesis   
Involvement of TGFBI-TAGLN axis in cancer stem cell property of head and neck squamous cell carcinoma
Authors: Motoharu Sarubo, Yasuhiro Mouri, Akira Moromizato, Azusa Yamada, Shengjan Jin, Wenhua Shao, Hiroko Hagita, Keiko Miyoshi, Yasusei Kudo
Journal: Sci Rep
PubMed ID: 38514830
Doi: 10.1038/s41598-024-57478-0
Products & Services: Molecular Biology Reagents   
AIRE is expressed in breast cancer TANs and TAMs to regulate the extrinsic apoptotic pathway and inflammation
Authors: Eva Källberg, Meliha Mehmeti-Ajradini, Frida Björk Gunnarsdottir, Marcus Göransson, Caroline Bergenfelz, Roni Allaoui Fredriksson, Catharina Hagerling, Martin E Johansson, Charlotte Welinder, Karin Jirström, Karin Leandersson
Journal: J Leukoc Biol
PubMed ID: 38060995
Doi: 10.1093/jleuko/qiad152
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Identification of mA RNA methylation genes in and expression profiling in response to different developmental and environmental stimuli
Authors: Mahbub Hasan, Zakia Sultana Nishat, Md Soyib Hasan, Tanvir Hossain, Ajit Ghosh
Journal: Biochem Biophys Rep
PubMed ID: 38511186
Doi: 10.1016/j.bbrep.2024.101677
Atrogin-1 promotes muscle homeostasis by regulating levels of endoplasmic reticulum chaperone BiP
Authors: Avnika A Ruparelia, Margo Montandon, Jo Merriner, Cheng Huang, Siew Fen Lisa Wong, Carmen Sonntag, Justin P Hardee, Gordon S Lynch, Lee B Miles, Ashley Siegel, Thomas E Hall, Ralf B Schittenhelm, Peter D Currie
Journal: JCI Insight
PubMed ID: 38530354
Doi: 10.1172/jci.insight.167578
Products & Services: Molecular Biology Reagents   
Mucosal tumor vaccination delivering endogenous tumor antigens protects against pulmonary breast cancer metastases
Authors: Friederike Oltmanns, Ana Vieira Antão, Pascal Irrgang, Vera Viherlehto, Leticia Jörg, Anna Schmidt, Jannik T Wagner, Michael Rückert, Ann-Sophie Flohr, Carol Imanuel Geppert, Benjamin Frey, Wibke Bayer, Claudia Gravekamp, Matthias Tenbusch, Udo Gaipl, Dennis Lapuente
Journal: J Immunother Cancer
PubMed ID: 38458636
Doi: 10.1136/jitc-2023-008652
Products & Services: Peptide Synthesis   
Oxygen Activation in Aromatic Ring Cleaving Salicylate Dioxygenase: Detection of Reaction Intermediates with a Nitro-substituted Substrate Analog
Authors: Qian Wang, Hanbin Li, Uran Bujupi, Janosch Gröning, Andreas Stolz, Angelo Bongiorno, Rupal Gupta
Journal: Chembiochem
PubMed ID: 38363551
Doi: 10.1002/cbic.202400023
Products & Services: Molecular Biology Reagents   
Poly(ADP-ribosyl)ation of TIMELESS limits DNA replication stress and promotes stalled fork protection
Authors: Julie Rageul , Natalie Lo , Amy L Phi , Jinal A Patel , Jennifer J Park , Hyungjin Kim
Journal: Cell Rep
PubMed ID: 38393943
Doi: 10.1016/j.celrep.2024.113845
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Novel Fragment Inhibitors of PYCR1 from Docking-Guided X-ray Crystallography
Authors: Kaylen R Meeks, Juan Ji , Mykola V Protopopov , Olga O Tarkhanova , Yurii S Moroz , John J Tanner
Journal: J Chem Inf Model
PubMed ID: 38411104
Doi: 10.1021/acs.jcim.3c01879
Products & Services: Molecular Biology Reagents   
Quantification of SARS-CoV-2 monoclonal IgG mass fraction by isotope dilution mass spectrometry
Authors: G Martos, M Bedu, R D Josephs, S Westwood, R I Wielgosz
Journal: Anal Bioanal Chem
PubMed ID: 38427100
Doi: 10.1007/s00216-024-05205-z
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Dependency on host vitamin B12 has shaped Mycobacterium tuberculosis Complex evolution
Authors: Elena Campos-Pardos, Santiago Uranga, Ana Picó, Ana Belén Gómez, Jesús Gonzalo-Asensio
Journal: Nat Commun
PubMed ID: 38461302
Doi: 10.1038/s41467-024-46449-8
Products & Services: Gene Synthesis   
Spatial enhancer activation influences inhibitory neuron identity during mouse embryonic development
Authors: Elena Dvoretskova, May C Ho, Volker Kittke, Florian Neuhaus, Ilaria Vitali, Daniel D Lam, Irene Delgado, Chao Feng, Miguel Torres, Juliane Winkelmann, Christian Mayer
Journal: Nat Neurosci
PubMed ID: 38528203
Doi: 10.1038/s41593-024-01611-9
Products & Services: Molecular Biology Reagents   
The Evolution and Application of a Novel DNA Aptamer Targeting Bone Morphogenetic Protein 2 for Bone Regeneration
Authors: Mengping Liu, Andrew B Kinghorn, Lin Wang, Soubhagya K Bhuyan, Simon Chi-Chin Shiu, Julian A Tanner
Journal: Molecules
PubMed ID: 38542880
Doi: 10.3390/molecules29061243
Products & Services: Gene Synthesis   
A pattern recognition receptor interleukin-1 receptor is involved in reproductive immunity in Macrobrachium nipponense ovary
Authors: Haifu Wan, Lei Yu, Xiaodong Cui, Shuai Guo, Shumei Mu, Xianjiang Kang
Journal: Fish Shellfish Immunol
PubMed ID: 38479568
Doi: 10.1016/j.fsi.2024.109481
Products & Services: Recombinant Proteins   
Caspase-2 protects against ferroptotic cell death
Authors: Swati Dawar, Mariana C Benitez, Yoon Lim, Toby A Dite, Jumana M Yousef, Niko Thio, Sylvain Garciaz, Thomas D Jackson, Julia V Milne, Laura F Dagley, Wayne A Phillips, Sharad Kumar, Nicholas J Clemons
Journal: Cell Death Dis
PubMed ID: 38429264
Doi: 10.1038/s41419-024-06560-6
Products & Services: Mutant Libraries   
Genetic fusion of CCL11 to antigens enhances antigenicity in nucleic acid vaccines and eradicates tumor mass through optimizing T-cell response
Authors: Hailong Qi, Zhongjie Sun, Tianle Gao, Yanling Yao, Yu Wang, Weiwei Li, Xudong Wang, Xiaofang Wang, Defang Liu, Jian-Dong Jiang
Journal: Mol Cancer
PubMed ID: 38459592
Doi: 10.1186/s12943-024-01958-4
Bioengineered Hydrogels Recapitulate Fibroblast Heterogeneity in Cancer
Authors: Nicholas Ching Wei Ho, Josephine Yu Yan Yap, Zixuan Zhao, Yunyun Wang, Kanishka Fernando, Constance H Li, Xue Lin Kwang, Hong Sheng Quah, Camille Arcinas, N Gopalakrishna Iyer, Eliza Li Shan Fong
Journal: Adv Sci (Weinh)
PubMed ID: 38493497
Doi: 10.1002/advs.202307129
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Mutational analysis in Corynebacterium stationis MFS transporters for improving nucleotide bioproduction
Authors: Keita Kinose, Keiko Shinoda, Tomoyuki Konishi, Hisashi Kawasaki
Journal: Appl Microbiol Biotechnol
PubMed ID: 38436751
Doi: 10.1007/s00253-024-13080-y
Products & Services: Gene Synthesis   
Small-molecule caspase-1 inhibitor CZL80 terminates refractory status epilepticus via inhibition of glutamatergic transmission
Authors: Fei Wang, Yu Wang, Qing-Yang Zhang, Ke-Yu Hu, Ying-Jie Song, Lin Yang, Fan Fei, Ceng-Lin Xu, Sun-Liang Cui, Ye-Ping Ruan, Yi Wang, Zhong Chen
Journal: Acta Pharmacol Sin
PubMed ID: 38514863
Doi: 10.1038/s41401-024-01257-0
Construction of recombinant pseudorabies virus expressing PCV2 Cap, PCV3 Cap, and IL-4: investigation of their biological characteristics and immunogenicity
Authors: Yanting Yang, Zhiwen Xu, Qian Tao, Lei Xu, Sirui Gu, Yao Huang, Zheyan Liu, Yang Zhang, Jianhua Wen, Siyuan Lai, Ling Zhu
Journal: Front Immunol
PubMed ID: 38571947
Doi: 10.3389/fimmu.2024.1339387
Products & Services: Molecular Biology Reagents   
Expanding the molecular language of protein liquid-liquid phase separation
Authors: Shiv Rekhi, Cristobal Garcia Garcia, Mayur Barai, Azamat Rizuan, Benjamin S Schuster, Kristi L Kiick, Jeetain Mittal
Journal: Nat Chem
PubMed ID: 38553587
Doi: 10.1038/s41557-024-01489-x
Products & Services: Molecular Biology Reagents   
Engineering APOBEC3A deaminase for highly accurate and efficient base editing
Authors: Lei Yang, Yanan Huo, Man Wang, Dan Zhang, Tianai Zhang, Hao Wu, Xichen Rao, Haowei Meng, Shuming Yin, Jiale Mei, Dexin Zhang, Xi Chen, Jia Lv, Meizhen Liu, Yiyun Cheng, Yuting Guan, Bo Feng, Gaojie Song, Chengqi Yi, Mingyao Liu, Fanyi Zeng, Liren Wang, Dali Li
Journal: Nat Chem Biol
PubMed ID: 38553609
Doi: 10.1038/s41589-024-01595-4
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Bacillus cereus cereolysin O induces pyroptosis in an undecapeptide-dependent manner
Authors: Yujian Wang, Jingchang Luo, Xiaolu Guan , Yan Zhao , Li Sun
Journal: Cell Death Discov
PubMed ID: 38458999
Doi: 10.1038/s41420-024-01887-7
The rapid proximity labeling system PhastID identifies ATP6AP1 as an unconventional GEF for Rheb
Authors: Ran Feng, Feng Liu, Ruofei Li, Zhifen Zhou, Zhuoheng Lin, Song Lin, Shengcheng Deng, Yingying Li, Baoting Nong, Ying Xia, Zhiyi Li, Xiaoqin Zhong, Shuhan Yang, Gang Wan, Wenbin Ma, Su Wu, Zhou Songyang
Journal: Cell Research
PubMed ID: 38448650
Doi: 10.1038/s41422-024-00938-z
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Structural analysis of phosphoribosyltransferase-mediated cell wall precursor synthesis in Mycobacterium tuberculosis
Authors: Shan Gao, Fangyu Wu, Sudagar S Gurcha, Sarah M Batt, Gurdyal S Besra, Zihe Rao, Lu Zhang
Journal: Nature
PubMed ID: 38491273
Doi: 10.1038/s41564-024-01643-8
Persistent immune imprinting occurs after vaccination with the COVID-19 XBB.1.5 mRNA booster in humans
Authors: M Alejandra Tortorici, Amin Addetia, Albert J Seo, Jack Brown, Kaiti Sprouse, Jenni Logue, Erica Clark, Nicholas Franko, Helen Chu, David Veesler
Journal: Immunity
PubMed ID: 38490197
Doi: 10.1016/j.immuni.2024.02.016
Products & Services: Plasmid DNA Preparation   
Specific protein-RNA interactions are mostly preserved in biomolecular condensates
Authors: Tebbe de Vries, Mihajlo Novakovic, Yinan Ni, Izabela Smok, Clara Inghelram, Maria Bikaki, Chris P Sarnowski, Yaning Han, Leonidas Emmanouilidis, Giacomo Padroni, Alexander Leitner, Frédéric H-T Allain
Journal: SCIENCE ADVANCES
PubMed ID: 38446881
Doi: 10.1126/sciadv.adm7435
Products & Services: PCR Cloning and Subcloning   
A uniquely efficacious type of CFTR corrector with complementary mode of action
Authors: Valentina Marchesin, Lucile Monnier, Peter Blattmann, Florent Chevillard, Christine Kuntz, Camille Forny, Judith Kamper, Rolf Studer, Alexandre Bossu, Eric A Ertel, Oliver Nayler, Christine Brotschi, Jodi T Williams, John Gatfield
Journal: SCIENCE ADVANCES
PubMed ID: 38427726
Doi: 10.1126/sciadv.adk1814
Products & Services: PCR Cloning and Subcloning   
FUS reads histone H3K36me3 to regulate alternative polyadenylation
Authors: Junqi Jia, Haonan Fan, Xinyi Wan, Yuan Fang, Zhuoning Li, Yin Tang, Yanjun Zhang, Jun Huang, Dong Fang
Journal: Nucleic Acids Research
PubMed ID: 38499486
Doi: 10.1093/nar/gkae184
An optimised protocol for the expression and purification of adenovirus core protein VII
Authors: Ajani Athukorala, Karla J Helbig, Brian P McSharry, Jade K Forwood, Subir Sarker
Journal: J Virol Methods
PubMed ID: 38432358
Doi: 10.1016/j.jviromet.2024.114907
Products & Services: Molecular Biology Reagents   
23-Hydroxybetulinic acid attenuates 5-fluorouracil resistance of colorectal cancer by modulating M2 macrophage polarization via STAT6 signaling
Authors: Zeping Fan, Yaru Cui, Lanying Chen, Peng Liu, Wenbin Duan
Journal: Cancer Immunol Immunother
PubMed ID: 38554148
Doi: 10.1007/s00262-024-03662-0
Products & Services: PCR Cloning and Subcloning   
mmu-miR-374b-5p modulated inflammatory factors via downregulation of C/EBP β/NF-κB signaling in Kupffer cells during Echinococcus multilocularis infection
Authors: Guiting Pu, Yanping Li, Tingli Liu, Hong Li, Liqun Wang, Guoliang Chen, Shanling Cao, Hong Yin, Tharheer Oluwashola Amuda, Xiaola Guo, Xuenong Luo
Journal: Parasit Vectors
PubMed ID: 38553755
Doi: 10.1186/s13071-024-06238-0
Products & Services: Molecular Biology Reagents   
Modulation of Primary and Secondary Processes in Tau Fibril Formation by Salt-Induced Dynamics
Authors: Arshad Abdul Vahid, Muhammed Shafeek Oliyantakath Hassan, Allwin Ebenezer Sahayaraj, Ann Teres Babu, Safwa T Kizhakkeduth, Vinesh Vijayan
Journal: ACS Chem Neurosci
PubMed ID: 38433380
Doi: 10.1021/acschemneuro.3c00852
Products & Services: Molecular Biology Reagents   
Knockout and Replacement Gene Surgery to Treat Rhodopsin-Mediated Autosomal Dominant Retinitis Pigmentosa
Authors: Xuehan Sun, Chen Liang, Yangcan Chen, Tongtong Cui, Jiabao Han, Moyu Dai, Ying Zhang, Qi Zhou, Wei Li
Journal: Hum Gene Ther
PubMed ID: 38368562
Doi: 10.1089/hum.2023.201
Products & Services: Molecular Biology Reagents   
Uncovering the photosystem I assembly pathway in land plants
Authors: Aihong Zhang, Lin Tian, Tong Zhu, Mengyu Li, Mengwei Sun, Ying Fang, Yi Zhang, Congming Lu
Journal: Nat Plants
PubMed ID: 38503963
Doi: 10.1038/s41477-024-01658-3
Products & Services: Catalog Peptides   
Absence of specific autoantibodies in patients with narcolepsy type 1 as indicated by an unbiased random peptide-displayed phage screening
Authors: Thi-Tuyet Trinh Tran, Thi-Hong Nhung Nguyen, Yves Dauvilliers, Roland Liblau, Xuan-Hung Nguyen
Journal: PLoS ONE
PubMed ID: 38442093
Doi: 10.1371/journal.pone.0297625
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A new trivalent recombinant protein for type 2 diabetes mellitus with oral delivery potential: design, expression, and experimental validation
Authors: Maryam Ehsasatvatan, Bahram Baghban Kohnehrouz
Journal: J Biomol Struct Dyn
PubMed ID: 38468545
Doi: 10.1080/07391102.2024.2329290
Products & Services: Molecular Biology Reagents   
Bactericera cockerelli Picorna-like Virus and Three New Viruses Found Circulating in Populations of Potato/Tomato Psyllids ()
Authors: Jennifer Dahan, Gardenia E Orellana, Kaleigh B Wald, Erik J Wenninger, W Rodney Cooper, Alexander V Karasev
Journal: Viruses
PubMed ID: 38543780
Doi: 10.3390/v16030415
Products & Services: PCR Cloning and Subcloning   
Rational Design of Key Enzymes to Efficiently Synthesize Phycocyanobilin in
Authors: Ziwei Wang, Jingwen Zhou, Jianghua Li, Guocheng Du, Jian Chen, Xinrui Zhao
Journal: Biomolecules
PubMed ID: 38540721
Doi: 10.3390/biom14030301
Continuous evolution of compact protein degradation tags regulated by selective molecular glues
Authors: Jaron A M Mercer, Stephan J DeCarlo, Shourya S Roy Burman, Vedagopuram Sreekanth, Andrew T Nelson, Moritz Hunkeler, Peter J Chen, Katherine A Donovan, Praveen Kokkonda, Praveen K Tiwari, Veronika M Shoba, Arghya Deb, Amit Choudhary, Eric S Fischer, David R Liu
Journal: Science
PubMed ID: 38484051
Doi: 10.1126/science.adk4422
Long-term antigen-specific immune response by an oncolytic adenovirus encoding SP-SA-E7-4-1BBL in HPV-16 cancer model
Authors: Alejandra G Martinez-Perez, Rodolfo Garza-Morales, Maria de J Loera-Arias, Sheila A Villa-Cedillo, Aracely Garcia-Garcia, Humberto Rodriguez-Rocha, Orlando E Flores-Maldonado, Jesus Valdes, Jose J Perez-Trujillo, Odila Saucedo-Cardenas
Journal: Mol Biol Rep
PubMed ID: 38460043
Doi: 10.1007/s11033-024-09303-0
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