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页码: 23/1072 每页显示数量

Identification of naturally occurring drug-resistant mutations of SARS-CoV-2 papain-like protease

Authors: Haozhou Tan, Qianru Zhang, Kyriakos Georgiou, Siyu Zhang, Kan Li, George Lambrinidis, Antonios Kolocouris, Xufang Deng, Jun Wang

Journal: Nature Communications

PubMed ID: 40379662

Doi: 10.1038/s41467-025-59922-9

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Freezing induced incorporation of betaine in lipid nanoparticles enhances mRNA delivery

Authors: Xingdi Cheng, Xia Zheng, Kun Tao, Haonan Huo, Zhang Liu, Xueguang Lu, Jianjun Wang

Journal: Nature Communications

PubMed ID: 40394015

Doi: 10.1038/s41467-025-60040-9

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Single-molecule analysis reveals the mechanism of chromatin ubiquitylation by variant PRC1 complexes

Authors: Alexandra Teslenko , Beat Fierz

Journal: SCIENCE ADVANCES

PubMed ID: 40397729

Doi: 10.1126/sciadv.adt7013

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Stomata-targeted nanocarriers enhance plant defense against pathogen colonization

Authors: Suppanat Puangpathumanond, Heng Li Chee, Cansu Sevencan, Xin Yang, On Sun Lau, Tedrick Thomas Salim Lew

Journal: Nature Communications

PubMed ID: 40410152

Doi: 10.1038/s41467-025-60112-w

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RabE1a- and SEC10b-mediated exocytosis and AP2β-mediated endocytosis are involved in the intracellular transport of tobamoviruses

Authors: Hua-Yu Ma, Yu Kong, Chao Geng, Yan-Ping Tian, Jun Jiang, Zhi-Yong Yan, Xiang-Dong Li

Journal: Plant Biotechnology Journal.

PubMed ID: 40408557

Doi: 10.1111/pbi.70138

Products & Services: Protein and Antibody Isolation

PKMYT1 kinase ameliorates cisplatin sensitivity in osteosarcoma

Authors: Binfeng Liu, Wei Li, Wenchao Zhang, Chengyao Feng, Lu Wan, Shasha He, Ruiling Xu, Zheng Fu, Zhongyue Liu, Haodong Xu, Xin Jin, Chao Tu, Zhihong Li

Journal: Signal Transduct Target Ther

PubMed ID: 40393983

Doi: 10.1038/s41392-025-02250-7

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Structural visualization of HECT-type E3 ligase Ufd4 accepting and transferring

Authors: Xiangwei Wu, Huasong Ai, Junxiong Mao, Hongyi Cai, Lu-Jun Liang, Zebin Tong, Zhiheng Deng, Qingyun Zheng, Lei Liu, Man Pan

Journal: nature COMMUNICATION

PubMed ID: 40341121

Doi: doi.org/10.1038/s41467-025-59569-6

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Structure-guided design of endosomolytic chloroquine-like lipid nanoparticles for mRNA delivery and genome editing

Authors: Zhen Liu, Jiacai Wu, Ning Wang, Yongqi Lin, Ruiteng Song, Min Zhang, Bin Li

Journal: Nature Communications

PubMed ID: 40335474

Doi: 10.1038/s41467-025-59501-y

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Discovery of benzethonium chloride as a potent STAT3 inhibitor for the treatment of HNSCC

Authors: Yuefeng Han; Shumin Li; Deshang Chen; Mingjie Zhang; Guoying Han; QianQian Xu; Xianming Ge; Mengli Wang; Yan Pan; Sien Ma; Beibei Xu; Mengmeng Deng; Bao Zhao

Journal: Frontiers in pharmacology

PubMed ID: 40242440

Doi: 10.3389/fphar.2025.1569570

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Design, synthesis, and mechanism study of dimerized phenylalanine derivatives as novel HIV-1 capsid inhibitors

Authors: Xujie Zhang; Lin Sun; Megan E. Meuser; Waleed A. Zalloum; Shujing Xu; Tianguang Huang; Srinivasulu Cherukupalli; Xiangyi Jiang; Xiao Ding; Yucen Tao; Dongwei Kang; Erik De Clercq; Christophe Pannecouque; Alexej Dick; Simon Cocklin; Xinyong Liu; Peng Zhan

Journal: European Journal of Medicinal Chemistry

PubMed ID: 34592608

Doi: 10.1016/j.ejmech.2021.113848

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Development of a single-dose Q fever vaccine with an injectable nanoparticle-loaded hydrogel: effect of sustained co-delivery of antigen and adjuvant

Authors: Lu Wang; Aaron Ramirez; Jiin Felgner; Enya Li; Jenny E. Hernandez-Davies; Anthony E. Gregory; Philip L. Felgner; Ali Mohraz; D. Huw Davies; Szu-Wen Wang

Journal: Drug Delivery

PubMed ID: 40314164

Doi: 10.1080/10717544.2025.2476144

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Crystal structure of Alzheimer's disease phospholipase D3 provides a molecular basis for understanding its normal and pathological functions

Authors: Kenta Ishii; Stefan J. Hermans; Maria Eleni Georgopoulou; Tracy L. Nero; Nancy C. Hancock; Gabriela A. N. Crespi; Michael A. Gorman; Jonathan H. Gooi; Michael W. Parker

Journal: The FEBS journal

PubMed ID: 39325669

Doi: 10.1111/febs.17277

SIRT2-mediated deacetylation of LCK governs the magnitude of T cell receptor signaling

Authors: Imene Hamaidi; Pingyan Cheng; Soo Young Jun; Alak Manna; Min-Hsuan Wang; Anh Nguyen; Ismail Can; Min G. Zhang; Odesha O. Taylor; Luis Uriel Lopez Bailon; Bin Fang; Bradford Perez; Ben C. Creelan; Andriy Marusyk; Dongjun Shin; Tae Hyun Hwang; Anders E. Berglund; Virginia S. Shapiro; Haitao M. Ji; Jos R. Conejo-Garcia; Sungjune Kim

Journal: nature immunology

PubMed ID: 41611868

Doi: 10.1038/s41590-025-02377-3

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SIRT2-mediated deacetylation of LCK governs the magnitude of T cell receptor signaling

Journal: nature immunology

PubMed ID: 41611868

Doi: 10.1038/s41590-025-02377-3

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CAMPER: mechanistic artificial intelligence for designing peptides that target MRSA persisters

Authors: Fadi Shehadeh; Biswajit Mishra; Raquel Ferrer-Espada; Anindya Basu; LewisOscar Felix; Charilaos Dellis; Narchonai Ganesan; Liyang Zhang; Andrew T. Martens; Youlian Goulev; Michael B. Sherman; Johan Paulsson; Mandar T. Naik; Paul P. Sotiriadis; Eleftherios Mylonakis

Journal: Nature Communications

PubMed ID: 41803147

Doi: 10.1038/s41467-026-70348-9

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CAMPER: mechanistic artificial intelligence for designing peptides that target MRSA persisters

Journal: Nature Communications

PubMed ID: 41803147

Doi: 10.1038/s41467-026-70348-9

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Influence of expression and purification protocols on G biochemical activity: kinetics of plant and mammalian G protein cycles

Authors: Timothy E. Gookin; David Chakravorty; Sarah M. Assmann

Journal: Frontiers in molecular biosciences

PubMed ID: 40260404

Doi: 10.3389/fmolb.2025.1513660

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De Novo Multi Mechanism Antimicrobial Peptide Design via Multimodal Deep Learning

Authors: Xiaojuan Li; Haifan Gong; Yue Wang; Yinuo Zhao; Lixiang Li; Peijing Bao; Qingzhou Kong; Jialu Fu; Boyao Wan; Yumeng Zhang; Jinghui Zhang; Jiekun Ni; Zhongxue Han; Xueping Nan; Kunping Ju; Longfei Sun; Yuerui Ma; Huijun Chang; Mengqi Zheng; Yanbo Yu; Xiaoyun Yang; Xiuli Zuo; Haina Wang; Yanqing Li

Journal: Advanced Science

PubMed ID: 41801219

Doi: 10.1002/advs.202515835

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Targeting Apicomplexan Parasites: Structural and Functional Characterization of Cryptosporidium Thioredoxin Reductase as a Novel Drug Target

Authors: Federica Gabriele; Jala A. Bogard; Marta Palerma; Matteo Ardini; Margaret E. Byrne; Xian-Ming Chen; Pavel A. Petukhov; Rodolfo Ippoliti; Francesco Angelucci; David L. Williams

Journal: Biochemistry

PubMed ID: 40304242

Doi: 10.1021/acs.biochem.5c00059

Influence of expression and purification protocols on G biochemical activity: kinetics of plant and mammalian G protein cycles

Authors: Timothy E. Gookin; David Chakravorty; Sarah M. Assmann

Journal: Frontiers in molecular biosciences

PubMed ID: 40260404

Doi: 10.3389/fmolb.2025.1513660

Products & Services: Gene Synthesis

Development of a single-dose Q fever vaccine with an injectable nanoparticle-loaded hydrogel: effect of sustained co-delivery of antigen and adjuvant

Authors: Lu Wang; Aaron Ramirez; Jiin Felgner; Enya Li; Jenny E. Hernandez-Davies; Anthony E. Gregory; Philip L. Felgner; Ali Mohraz; D. Huw Davies; Szu-Wen Wang

Journal: Drug Delivery

PubMed ID: 40314164

Doi: 10.1080/10717544.2025.2476144

Products & Services: Endotoxin Detection & Removal System

Development of a single-dose Q fever vaccine with an injectable nanoparticle-loaded hydrogel: effect of sustained co-delivery of antigen and adjuvant

Authors: Lu Wang; Aaron Ramirez; Jiin Felgner; Enya Li; Jenny E. Hernandez-Davies; Anthony E. Gregory; Philip L. Felgner; Ali Mohraz; D. Huw Davies; Szu-Wen Wang

Journal: Drug Delivery

PubMed ID: 40314164

Doi: 10.1080/10717544.2025.2476144

Products & Services: Endotoxin Detection & Removal System

Immunoinformatic strategy for developing multi-epitope subunit vaccine against Helicobacter pylori

Authors: Md. Nahian; Md. Rasel Khan; Fabiha Rahman; Hossain Mohammed Reza; Imren Bayil; Tanjum Ahmed Nodee; Tabassum Basher; Mostafizur Rahaman Sany; Rabeya Najnin Munmun; S. M. Ariful Habib; Lincon Mazumder; Mrityunjoy Acharjee; Abu Tayab Moin; Abu Tayab Moin; Abu Tayab Moin

Journal: PLoS ONE

PubMed ID: 39919064

Doi: 10.1371/journal.pone.0318750

An intranasal subunit vaccine induces protective systemic and mucosal antibody immunity against respiratory viruses in mouse models

Authors: Aina Karen Anthi, Anette Kolderup, Eline Benno Vaage, Malin Bern, Sopisa Benjakul, Elias Tjärnhage, Fulgencio Ruso-Julve, Kjell-Rune Jensen, Heidrun Elisabeth Lode, Marina Vaysburd, Jeannette Nilsen, Marie Leangen Herigstad, Siri Aastedatter Sakya, Lisa Tietze, Diego Pilati, Mari Nyquist-Andersen, Mirjam Dürkoop, Torleif Tollefsrud Gjølberg, Linghang Peng, Stian Foss, Morten C Moe, Benjamin E Low, Michael V Wiles, David Nemazee, Frode L Jahnsen, John Torgils Vaage, Kenneth A Howard, Inger Sandlie, Leo C James, Gunnveig Grødeland, Fridtjof Lund-Johansen, Jan Terje Andersen

Journal: Nature Communications

PubMed ID: 40312392

Doi: 10.1038/s41467-025-59353-6

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LRM3 positively regulates stem lodging resistance by degradating MYB6 transcriptional repressor in soybean

Authors: Yongheng Ye, Zhiyuan Cheng, Xinjing Yang, Suxin Yang, Kuanqiang Tang, Hui Yu, Jinshan Gao, Yaohua Zhang, Jiantian Leng, Wei Zhang, Ye Zhang, Moran Bu, Zhengwei Liang, Zhicheng Dong, Zhonghui Zhang, Xianzhong Feng

Journal: Plant Biotechnology Journal.

PubMed ID: 40333576

Doi: 10.1111/pbi.70124

Products & Services: Protein Electrophoresis and Western

Dual inhibition of DNA-PK and Polϴ boosts precision of diverse prime editing systems

Authors: Louis C Dacquay, Panagiotis Antoniou, Astrid Mentani, Niklas Selfjord, Hanna Mårtensson, Pei-Pei Hsieh, Salman Mustfa, George Thom, Sandra Wimberger, Mike Firth, Nina Akrap, Marcello Maresca, Martin Peterka

Journal: Nature Communications

PubMed ID: 40341582

Doi: 10.1038/s41467-025-59708-z

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DDX3 Regulates the Cap-Independent Translation of the Japanese Encephalitis Virus via Its Interactions with PABP1 and the Untranslated Regions of the Viral Genome

Authors: Chenxi Li, Linjie Zhang, Chenyang Tang, Xuan Chen, Jing Shi, Qingyu Li, Xue Jiao, Jinyao Guo, Bin Wang, Kefan Bu, Abdul Wahaab, Yuguo Yuan, Ming-An Sun, Yanhua Li

Journal: Advanced Science

PubMed ID: 40344524

Doi: 10.1002/advs.202502493

C-mannosyltransferase DPY19L1L-mediated Reissner Fiber formation is critical for zebrafish (Danio rerio) body axis straightening

Authors: Guiyou Tian, Lirong Huang, Zhaopeng Xu, Chen Lu, Wei Yuan, Yulin Wu, Zhipeng Liao, Jia Gao, Qiang Luo, Bo Cheng, Xinjun Liao, Huiqiang Lu

Journal: SCIENCE ADVANCES

PubMed ID: 40344050

Doi: 10.1126/sciadv.adv2032

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Auxin-salicylic acid seesaw regulates the age-dependent balance between plant growth and herbivore defense

Authors: Wen-Hao Han, Feng-Bin Zhang, Shun-Xia Ji, Kai-Lu Liang, Jun-Xia Wang, Xiao-Ping Fan, Shu-Sheng Liu, Xiao-Wei Wang

Journal: SCIENCE ADVANCES

PubMed ID: 40344064

Doi: 10.1126/sciadv.adu5141

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Structural and molecular basis of PCNA-activated FAN1 nuclease function in DNA repair

Authors: F Li, A S Phadte, M Bhatia, S Barndt, A R Monte Carlo Iii, C-F D Hou, R Yang, S Strock, A Pluciennik

Journal: Nature Communications

PubMed ID: 40368897

Doi: 10.1038/s41467-025-59323-y

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Structural determinants of inverted Alu-mediated backsplicing revealed by -MaP and -JuMP

Authors: Justin M Waldern, Colin Taylor, Catherine A Giannetti, Patrick S Irving, Scott R Allen, Mingyi Zhu, Rolf Backofen, Dave Mathews, Kevin M Weeks, Alain Laederach

Journal: Nucleic Acids Research

PubMed ID: 39713457

Doi: 10.1101/2024.12.13.628372

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FcRn-silencing of IL-12Fc prevents toxicity of local IL-12 therapy and prolongs survival in experimental glioblastoma

Authors: Michal Beffinger, Linda Schellhammer, Betül Taskoparan, Sereina Deplazes, Ulisse Salazar, Nazanin Tatari, Frauke Seehusen, Leopold von Balthazar, Carl Philipp Zinner, Sabine Spath, Tala Shekarian, Marie-Françoise Ritz, Marta McDaid, Pascal Egloff, Iwan Zimmermann, Hideho Okada, E Sally Ward, Jack Rohrer, Markus A Seeger, Thorsten Buch, Gregor Hutter, Johannes Vom Berg

Journal: Nature Communications

PubMed ID: 40404625

Doi: 10.1038/s41467-025-59971-0

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The ALX4 dimer structure provides insight into how disease alleles impact function

Authors: Brittany Cain , Zhenyu Yuan , Evelyn Thoman, Rhett A Kovall , Brian Gebelein

Journal: Nature Communications

PubMed ID: 40410151

Doi: 10.1038/s41467-025-59728-9

Human skeletal development and regeneration are shaped by functional diversity of stem cells across skeletal sites

Authors: Thomas H Ambrosi, Sahar Taheri, Kun Chen, Rahul Sinha, Yuting Wang, Ethan J Hunt, L Henry Goodnough, Matthew P Murphy, Holly M Steininger, Malachia Y Hoover, Franco Felix, Kelly C Weldon, Lauren S Koepke, Jan Sokol, Daniel Dan Liu, Liming Zhao, Stephanie D Conley, Wan-Jin Lu, Maurizio Morri, Norma F Neff, Noelle L Van Rysselberghe, Erika E Wheeler, Yongheng Wang, J Kent Leach, Augustine Saiz, Aijun Wang, George P Yang, Stuart Goodman, Julius A Bishop, Michael J Gardner, Derrick C Wan, Irving L Weissman, Michael T Longaker, Debashis Sahoo, Charles K F Chan

Journal: Cell Stem Cell

PubMed ID: 40118065

Doi: 10.1016/j.stem.2025.02.013

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Ferritin From Striped Stem Borer (Chilo suppressalis) Oral Secretion Acts as an Effector Helping to Maintain Iron Homoeostasis and Impair Defenses in Rice

Authors: Shan Yu, Shuai Li, Jing Li, Chen-Yang Wang, Lei Yang, Jing Li, Yue Meng, Xin-Yang Tan, Mao-Feng Jing, Guang-Hua Luo, Ji-Chao Fang, Rui Ji

Journal: PLANT CELL AND ENVIRONMENT

PubMed ID: 39812459

Doi: 10.1111/pce.15386

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Fe(III)−H2O2 as an Alternative Oxidant for Catalytic Sulfoxidation in Cytochrome P450 Enzymes: Combined Theoretical and Experimental Evidence

Authors: Musen Li, Langxing Liao, Zhihui Jiang, Zongyu Bao, Shengbiao Ji, Binju Wang

Journal: ACS catalysis

Doi: doi.org/10.1021/acscatal.5c01673

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A general assay platform to study protein pharmacology using ligand-dependent structural dynamics

Authors: Daniel A Ciulla, Patricia K Dranchak, Mahesh Aitha, Renier H P van Neer, Divia Shah, Ravi Tharakan, Kelli M Wilson, Yuhong Wang, John C Braisted, James Inglese

Journal: nature COMMUNICATION

PubMed ID: 40346061

Doi: 10.1038/s41467-025-59658-6

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Design and structural basis of selective 1,4-dihydropyridine inhibitors of the calcium-activated potassium channel KCa3.1

Authors: Seow Theng Ong, Young-Woo Nam, Joshua A Nasburg, Alena Ramanishka, Xuan Rui Ng, Zhong Zhuang, Stephanie Shee Min Goay, Hai M Nguyen, Latika Singh, Vikrant Singh, Alicia Rivera, M Elaine Eyster, Yang Xu, Seth L Alper, Heike Wulff, Miao Zhang, K George Chandy

Journal: Proc Natl Acad Sci U S A

PubMed ID: 40294255

Doi: 10.1073/pnas.2425494122

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TrkC protects against osteoarthritis progression by maintaining articular cartilage homeostasis

Authors: Yongyun Chang, Keyu Kong, Hua Qiao, Minghao Jin, Xinru Wu, Wenxuan Fan, Jingwei Zhang, Yansong Qi, Yongsheng Xu, An Qin, Zanjing Zhai, Huiwu Li

Journal: International journal of biological sciences

PubMed ID: 40520017

Doi: 10.7150/ijbs.108832

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DNA hypermethylation of PLTP mediated by DNMT3B aggravates vascular dysfunction in diabetic retinopathy via the AKT/GSK3β signaling pathway

Authors: Chunyang Cai, Chufeng Gu, Chunren Meng, Yujie Wang, Qingquan Wei, Shuai He, Dongwei Lai, Xingyun Wang, Tengfei Wang, Qinghua Qiu

Journal: Clinical epigenetics

PubMed ID: 40380281

Doi: 10.1186/s13148-025-01874-4

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Mechanistic insights into the stimulation of the histone H3K9 methyltransferase Clr4 by proximal H3K14 ubiquitination

Authors: Yunxiang Du , Maoshen Sun , Zhengqing Li , Xiangwei Wu , Qian Qu , Huasong Ai , Lei Liu

Journal: SCIENCE ADVANCES

PubMed ID: 40446033

Doi: 10.1126/sciadv.adu1864

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CRISPR-Based Environmental Biosurveillance Assisted via Artificial Intelligence Design of Guide-RNAs

Authors: Benjamín Durán-Vinet, Jo-Ann L. Stanton, Gert-Jan Jeunen, Ulla von Ammon, Jackson Treece, Xavier Pochon, Anastasija Zaiko, Neil J. Gemmell

Journal: Environmental DNA

Doi: doi.org/10.1002/edn3.70105

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A basigin antibody modulates MCTs to impact tumor metabolism and immunity

Authors: Heng Zhang, Xuemei Yang, Yue Xue, Yi Huang, Yingxi Mo, Yurun Huang, Hong Zhang, Xiaofei Zhang, Weixin Zhao, Bin Jia, Ningning Li, Ning Gao, Yue Yang, Dongxi Xiang, Shan Wang, Yi Qin Gao, Jun Liao

Journal: Cell Discovery

PubMed ID: 40324980

Doi: 10.1038/s41421-025-00777-1

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Microglial MS4A4A Protects against Epileptic Seizures in Alzheimer's Disease

Authors: Meng Jiang, Qingqing Li, Jianhui Chen, Ruochong Li, Jun Yao, Yong Hu, Haizheng Zhang, Lixin Cai, Maoguo Luo, Yu Sun, Wenwen Zeng

Journal: Advanced Science

PubMed ID: 40349168

Doi: 10.1002/advs.202417733

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HR eye & MMR eye: one-day assessment of DNA repair-defective tumors eligible for targeted therapy

Authors: Shinta Saito, Shingo Kato, Usaki Arai, Atsuki En, Jun Tsunezumi, Taichi Mizushima, Kensuke Tateishi, Noritaka Adachi

Journal: Nature Communications

PubMed ID: 40355434

Doi: 10.1038/s41467-025-59462-2

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A FAN1 point mutation associated with accelerated Huntington's disease progression alters its PCNA-mediated assembly on DNA

Authors: Jonas Aretz, Gayathri Jeyasankar, Anna Salerno-Kochan, Maren Thomsen, Gabriel Thieulin-Pardo, Tasir Haque, Edith Monteagudo, Dan Felsenfeld, Michael Finley, Thomas F Vogt, Julien Boudet, Brinda C Prasad

Journal: Nature Communications

PubMed ID: 40368883

Doi: 10.1038/s41467-025-59324-x

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Structural basis of phosphorylation-independent nuclear import of CIRBP by TNPO3

Authors: Qishun Zhou, Theo Sagmeister, Saskia Hutten, Benjamin Bourgeois, Tea Pavkov-Keller, Dorothee Dormann, Tobias Madl

Journal: Nature Communications

PubMed ID: 40360518

Doi: 10.1038/s41467-025-59802-2

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Modular deregulation of central carbon metabolism for efficient xylose utilization in Saccharomyces

Authors: Xiaowei Li, Yanyan Wang, Xin Chen, Leon Eisentraut, Chunjun Zhan, Jens Nielsen, Yun Chen

Journal: Nature Communications

PubMed ID: 40379631

Doi: 10.1038/s41467-025-59966-x

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Inhibiting peptidylarginine deiminases (PAD1-4) by targeting a Ca2+ dependent allosteric binding site

Authors: Leslie A Dakin, Li Xing, Justin Hall, Weidong Ding, Felix F Vajdos, Jeffrey W Pelker, Simeon Ramsey, Paul Balbo, Parag V Sahasrabudhe, Mary Ellen Banker, Won Young Choi, Stephen W Wright, Jeanne S Chang, John M Curto, Jennifer E Davoren, Susan E Drozda, Kimberly F Fennell, Kentaro Futatsugi, Steve Kortum, Katherine L Lee, Shenping Liu, Frank Lovering, Jennifer A Nicki, John I Trujillo, Fabien Vincent, Mark E Schnute

Journal: Nature Communications

PubMed ID: 40379660

Doi: 10.1038/s41467-025-59919-4

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Interaction networks of SIM-binding groove mutants reveal alternate modes of SUMO binding and profound impact on SUMO conjugation

Authors: Laura A Claessens, Matty Verlaan-de Vries, Nienke Broekman, Martijn S Luijsterburg, Alfred C O Vertegaal

Journal: SCIENCE ADVANCES

PubMed ID: 40367183

Doi: 10.1126/sciadv.adp2643

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