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Dual mode of DDX3X as an ATP-dependent RNA helicase and ATP-independent nucleic acid chaperone

Authors: Yi-Ning He, Xiao-Rui Han, Dong Wang, Jia-Li Hou, Xi-Miao Hou

Journal: Biochem Biophys Res Commun

PubMed ID: 38669753

Doi: 10.1016/j.bbrc.2024.149964

Products & Services: DNA Sequencing

Coiled-Coil Protein Hydrogels Engineered with Minimized Fiber Diameters for Sustained Release of Doxorubicin in Triple-Negative Breast Cancer

Authors: Dustin Britton, Jakub Legocki, Deven Paul, Olga Katsara, Orlando Aristizabal, Neelam Pandya, Orin Mishkit, Yingxin Xiao, Matias Aristizabal, Neha Rahman, Robert Schneider, Youssef Z Wadghiri, Jin Kim Montclare

Journal: ACS Biomater Sci Eng

PubMed ID: 38622760

Doi: 10.1021/acsbiomaterials.4c00349

Products & Services: Molecular Biology Reagents

Depolymerization of SUMO chains induces slender to stumpy differentiation in T brucei bloodstream parasites

Authors: Paula Ana Iribarren, Lucía Ayelén Di Marzio, María Agustina Berazategui, Andreu Saura, Lorena Coria, Juliana Cassataro, Federico Rojas, Miguel Navarro, Vanina Eder Alvarez

Journal: PLoS Pathog

PubMed ID: 38635823

Doi: 10.1371/journal.ppat.1012166

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Identification of a homoarginine biosynthetic gene from a microcystin biosynthetic pathway in Fischerella sp PCC 9339

Authors: Xiaodan Ouyang, Matti Wahlsten, Maija Pollari, Endrews Delbaje, Jouni Jokela, David P Fewer

Journal: Toxicon

PubMed ID: 38670499

Doi: 10.1016/j.toxicon.2024.107733

Products & Services: Molecular Biology Reagents

RATA: A novel class A carbapenemase with broad geographic distribution and potential for global spread

Authors: Hongyan Luo, Zhishuang Yang, Ting Lei, Caixia Li, Zuoyong Zhou, Mingshu Wang, Dekang Zhu, Pei Li, Anchun Cheng

Journal: Sci Total Environ

PubMed ID: 38692330

Doi: 10.1016/j.scitotenv.2024.172873

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Kalium channelrhodopsins effectively inhibit neurons

Authors: Stanislav Ott, Sangyu Xu, Nicole Lee, Ivan Hong, Jonathan Anns, Danesha Devini Suresh, Zhiyi Zhang, Xianyuan Zhang, Raihanah Harion, Weiying Ye, Vaishnavi Chandramouli, Suresh Jesuthasan, Yasunori Saheki, Adam Claridge-Chang

Journal: Nat Commun

PubMed ID: 38658537

Doi: 10.1038/s41467-024-47203-w

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Characterization of 35 novel NR5A1/SF-1 variants identified in individuals with atypical sexual development: The SF1next study

Authors: Rawda Naamneh Elzenaty, Idoia Martinez de Lapiscina, Chrysanthi Kouri, Kay-Sara Sauter, Grit Sommer, Luis Castaño, Christa E Flück

Journal: J Clin Endocrinol Metab

PubMed ID: 38623954

Doi: 10.1210/clinem/dgae251

Products & Services: Molecular Biology Reagents

Selective Detection of Active Extracellular Granzyme A by Using a Novel Fluorescent Immunoprobe with Application to Inflammatory Diseases

Authors: Ana Senan-Salinas, Laura Comas, Patricia Esteban, Marcela Garzón-Tituaña, Zhiming Cheng, Llipsy Santiago, Maria Pilar Domingo, Ariel Ramírez-Labrada, José Ramón Paño-Pardo, Marc Vendrell, Julián Pardo, Maykel A Arias, Eva M Galvez

Journal: ACS Pharmacol Transl Sci

PubMed ID: 38751645

Doi: 10.1021/acsptsci.4c00065

Products & Services: Proteins, Expression, Isolation and Analysis

Identification and Quantification of a Pneumococcal Cell Wall Polysaccharide by Antibody-Enhanced Chromatography Assay

Authors: James Z Deng, Zhifeng Chen, James Small, Yue Yuan, Kara Cox, Aimin Tang, Jeanette Roman, Liming Guan, Katrina Feller, Frances Ansbro, Kalpit Vora

Journal: Vaccines (Basel)

PubMed ID: 38793720

Doi: 10.3390/vaccines12050469

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Intestinal MAdCAM-1 imaging as biomarker for prognostic in murine models of multiple sclerosis

Authors: Erwan Baudron, Sara Martinez de Lizarrondo, Maxime Gauberti, Barbara Delaunay-Piednoir, Antoine P Fournier, Denis Vivien, Fabian Docagne, Isabelle Bardou

Journal: Brain Behav Immun

PubMed ID: 38604270

Doi: 10.1016/j.bbi.2024.04.006

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An improved system to generate recombinant canine distemper virus

Authors: Huai Cheng, Hewei Zhang, Huayun Zhang, Huanchang Cai, Min Liu, Mingen Yu, Meihua Xiang, Shubo Wen, Jingqiang Ren

Journal: BMC Vet Res

PubMed ID: 38678249

Doi: 10.1186/s12917-023-03830-x

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Reverse-Phase Protein Microarrays for Overexpressed Lysates Reveal a Novel Tyrosine Kinase

Authors: Batuhan Birol Keskin, Chien-Sheng Chen, Pei-Shan Tsai, Pin-Xian Du, John Harvey M Santos, Guan-Da Syu

Journal: Anal Chem

PubMed ID: 38683735

Doi: 10.1021/acs.analchem.4c00965

Products & Services: Proteins, Expression, Isolation and Analysis

Functional and structural insights into activation of TRPV2 by weak acids

Authors: Ferdinand M Haug, Ruth A Pumroy, Akshay Sridhar, Sebastian Pantke, Florian Dimek, Tabea C Fricke, Axel Hage, Christine Herzog, Frank G Echtermeyer, Jeanne de la Roche, Adrian Koh, Abhay Kotecha, Rebecca J Howard, Erik Lindahl, Vera Moiseenkova-Bell, Andreas Leffler

Journal: EMBO J

PubMed ID: 38671253

Doi: 10.1038/s44318-024-00106-4

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Tumor vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA): Suppresses macrophage capping protein beyond STING activation

Authors: Zhiyong Xiao, Xia Cui, Feng Liu, Ying Wang, Xiao Liu, Wenxia Zhou, Yongxiang Zhang

Journal: Biochim Biophys Acta Mol Basis Dis

PubMed ID: 38565383

Doi: 10.1016/j.bbadis.2024.167149

Products & Services: Proteins, Expression, Isolation and Analysis

Graphene oxide films as a novel tool for the modulation of myeloid-derived suppressor cell activity in the context of multiple sclerosis

Authors: Celia Camacho-Toledano, Isabel Machín-Díaz, Rafael Lebrón-Galán, Ankor González-Mayorga, Francisco J Palomares, María C Serrano, Diego Clemente

Journal: Nanoscale

PubMed ID: 38498071

Doi: 10.1039/d3nr05351b

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Structural analyses of the GI4 norovirus by cryo-electron microscopy and X-ray crystallography revealing binding sites for human monoclonal antibodies

Authors: Tomomi Kimura-Someya, Kazushige Katsura, Miyuki Kato-Murayama, Toshiaki Hosaka, Tomomi Uchikubo-Kamo, Kentaro Ihara, Kazuharu Hanada, Shin Sato, Kazutaka Murayama, Michiyo Kataoka, Mikako Shirouzu, Yuichi Someya

Journal: J Virol

PubMed ID: 38593321

Doi: 10.1128/jvi.00197-24

Products & Services: Gene Synthesis

Transcriptome analysis reveals the mechanism of antifungal peptide epinecidin-1 against Botrytis cinerea by mitochondrial dysfunction and oxidative stress

Authors: Li Fan, Yingying Wei, Yi Chen, Meriem Ouaziz, Shu Jiang, Feng Xu, Hongfei Wang, Xingfeng Shao

Journal: Pestic Biochem Physiol

PubMed ID: 38879298

Doi: 10.1016/j.pestbp.2024.105932

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Enhancement of SARS-CoV-2 mRNA Vaccine Efficacy through the Application of TMSB10 UTR for Superior Antigen Presentation and Immune Activation

Authors: Xiaoyan Ding, Yuxin Zhou, Jiuxiang He, Jing Zhao, Jintao Li

Journal: Vaccines (Basel)

PubMed ID: 38675814

Doi: 10.3390/vaccines12040432

Products & Services: Molecular Biology Reagents

Structure and dynamics of a pentameric KCTD5/CUL3/Gβγ E3 ubiquitin ligase complex

Authors: Duc Minh Nguyen, Deanna H Rath, Dominic Devost, Darlaine Pétrin, Robert Rizk, Alan X Ji, Naveen Narayanan, Darren Yong, Andrew Zhai, Douglas A Kuntz, Maha U Q Mian, Neil C Pomroy, Alexander F A Keszei, Samir Benlekbir, Mohammad T Mazhab-Jafari, John L Rubinstein, Terence E Hébert, Gilbert G Privé

Journal: Proc Natl Acad Sci U S A

PubMed ID: 38625940

Doi: 10.1073/pnas.2315018121

Products & Services: Gene Synthesis

Efficient gene knockout and genetic interaction screening using the in4mer CRISPR/Cas12a multiplex knockout platform

Authors: Nazanin Esmaeili Anvar, Chenchu Lin, Xingdi Ma, Lori L Wilson, Ryan Steger, Annabel K Sangree, Medina Colic, Sidney H Wang, John G Doench, Traver Hart

Journal: Nat Commun

PubMed ID: 38678031

Doi: 10.1038/s41467-024-47795-3

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A folate inhibitor exploits metabolic differences in Pseudomonas aeruginosa for narrow-spectrum targeting

Authors: Connor Chain, Joseph P Sheehan, Xincheng Xu, Soodabeh Ghaffari, Aneesh Godbole, Hahn Kim, Joel S Freundlich, Joshua D Rabinowitz, Zemer Gitai

Journal: Nature Microbiology

PubMed ID: 38594311

Doi: 10.1038/s41564-024-01665-2

Products & Services: Antibody Modification and Purification Services

Antisense oligonucleotide therapeutic approach for Timothy syndrome

Authors: Xiaoyu Chen, Fikri Birey,John Huguenard, Sergiu P Pașca

Journal: Nature

PubMed ID: 38658687

Doi: 10.1038/s41586-024-07310-6

Structural basis for human Cav3.2 inhibition by selective antagonists

Authors: Jian Huang, Xiao Fan, Xueqin Jin, Chen Lyu, Qinmeng Guo, Tao Liu, Jiaofeng Chen, Amaël Davakan, Philippe Lory, Nieng Yan

Journal: Cell Research

PubMed ID: 38605177

Doi: 10.1038/s41422-024-00959-8

Products & Services: Peptide Synthesis

Comparison of antibody-based immunotherapeutics for malignant hematological disease in an experimental murine model

Authors: Karin Frebel, Jörn C Albring, Anika Wohlgemuth, Christian Schwöppe, Stephan Hailfinger, Georg Lenz, Matthias Stelljes

Journal: Blood

PubMed ID: 38197968

Doi: 10.1182/bloodadvances.2023011647

Products & Services: Molecular Biology Reagents

Somatic and intergenerational G4C2 hexanucleotide repeat instability in a human C9orf72 knock-in mouse model

Authors: Nada Kojak, Junko Kuno, Kristina E Fittipaldi, Ambereen Khan, David Wenger, Michael Glasser, Roberto A Donnianni, Yajun Tang, Jade Zhang, Katie Huling, Roxanne Ally, Alejandro O Mujica, Terrence Turner, Gina Magardino, Pei Yi Huang, Sze Yen Kerk, Gustavo Droguett, Marine Prissette, Jose Rojas, Teodoro Gomez, Anthony Gagliardi, Charleen Hunt, Jeremy S Rabinowitz, Guochun Gong, William Poueymirou, Eric Chiao, Brian Zambrowicz, Chia-Jen Siao, Daisuke Kajimura

Journal: Nucleic Acids Res

PubMed ID: 38597682

Doi: 10.1093/nar/gkae250

Products & Services: PCR Cloning and Subcloning

A hemoprotein with a zinc-mirror heme site ties heme availability to carbon metabolism in cyanobacteria

Authors: Nicolas Grosjean, Estella F Yee, Desigan Kumaran, Kriti Chopra, Macon Abernathy, Sandeep Biswas, James Byrnes, Dale F Kreitler, Jan-Fang Cheng, Agnidipta Ghosh, Steven C Almo, Masakazu Iwai, Krishna K Niyogi, Himadri B Pakrasi, Ritimukta Sarangi, Hubertus van Dam, Lin Yang, Ian K Blaby, Crysten E Blaby-Haas

Journal: Nature Communications

PubMed ID: 38609367

Doi: 10.1038/s41467-024-47486-z

Products & Services: Proteins, Expression, Isolation and Analysis

Human inherited PD-L1 deficiency is clinically and immunologically less severe than PD-1 deficiency

Authors: Matthew B Johnson, Masato Ogishi, Clara Domingo-Vila, Elisa De Franco, Matthew N Wakeling, Zineb Imane, Brittany Resnick, Evangelia Williams, Rui Pedro Galão, Richard Caswell, James Russ-Silsby, Yoann Seeleuthner , Darawan Rinchai, Iris Fagniez, Basilin Benson, Matthew J Dufort, Cate Speake , Megan E Smithmyer, Michelle Hudson, Rebecca Dobbs; EXE-T1D consortium; Zoe Quandt, Andrew T Hattersley ,Peng Zhang, Stephanie Boisson-Dupuis , Mark S Anderson, Jean-Laurent Casanova, Timothy I Tree, Richard A Oram

Journal: Journal Of Experimental Medicine

PubMed ID: 38634869

Doi: 10.1084/jem.20231704

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Targeting branched N-glycans and fucosylation sensitizes ovarian tumors to immune checkpoint blockade

Authors: Hao Nie, Pratima Saini, Taito Miyamoto, Liping Liao, Rafal J Zielinski, Heng Liu, Wei Zhou, Chen Wang, Brennah Murphy, Martina Towers, Tyler Yang, Yuan Qi, Toshitha Kannan, Andrew Kossenkov, Hiroaki Tateno, Daniel T Claiborne, Nan Zhang, Mohamed Abdel-Mohsen, Rugang Zhang

Journal: Nature Communications

PubMed ID: 38565883

Doi: 10.1038/s41467-024-47069-y

Products & Services: Gene Synthesis

Measles Virus-Based Vaccine Expressing Membrane-Anchored Spike of SARS-CoV-2 Inducing Efficacious Systemic and Mucosal Humoral Immunity in Hamsters

Authors: Zhi-Hui Yang 1, Yan-Li Song 1, Jie Pei 1, Song-Zhuang Li 1, Rui-Lun Liu 1, Yu Xiong 1, Jie Wu 1, Yuan-Lang Liu 1, Hui-Fen Fan 1, Jia-Hui Wu 1, Ze-Jun Wang 1, Jing Guo 1, Sheng-Li Meng 1, Xiao-Qi Chen 1, Jia Lu 1, Shuo Shen 1

Journal: Viruses

PubMed ID: 38675901

Doi: 10.3390/v16040559

Products & Services: Molecular Biology Reagents

A rational designed multi-epitope vaccine elicited robust protective efficacy against Klebsiella pneumoniae lung infection

Authors: Jingwen Liao, Xiaoli Zhang, Xi Zeng, Zhuo Zhao, Tianjun Sun, Zhenping Xia, Haiming Jing, Yue Yuan, Zhifu Chen, Qiang Gou, Liqun Zhao, Weijun Zhang, Quanming Zou, Jinyong Zhang

Journal: Biomed Pharmacother

PubMed ID: 38643540

Doi: 10.1016/j.biopha.2024.116611

Products & Services: Molecular Biology Reagents

Kirigami-inspired artificial spidroin microneedles for wound patches

Authors: Yongji Xiong, Yue Xu, Baoyang Lin, Bingfang He, Bingbing Gao

Journal: Int J Biol Macromol

PubMed ID: 38663709

Doi: 10.1016/j.ijbiomac.2024.131838

Products & Services: Proteins, Expression, Isolation and Analysis

Identification, Expression and Evolutional Analysis of Two Genes in Amphioxus

Authors: Yajun Wang, Jingyuan Lin, Wenjin Li, Guangdong Ji, Zhenhui Liu

Journal: Animals (Basel)

PubMed ID: 38672288

Doi: 10.3390/ani14081140

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Identification and characterization of emGalaseE, a β-1,4 galactosidase from Elizabethkingia meningoseptica, and its application on living cell surface

Authors: Yongliang Tong, Xinrong Lu, Danfeng Shen, Lin Rao, Lin Zou, Shaoxian Lyu, Linlin Hou, Guiqin Sun, Li Chen

Journal: Biological Macromolecules

PubMed ID: 38657932

Doi: 10.1016/j.ijbiomac.2024.131766

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Protein language models-assisted optimization of a uracil-N-glycosylase variant enables programmable T-to-G and T-to-C base editing

Authors: Yan He, Xibin Zhou, Chong Chang, Ge Chen, Weikuan Liu, Geng Li, Xiaoqi Fan, Mingsun Sun, Chensi Miao, Qianyue Huang, Yunqing Ma, Fajie Yuan, Xing Chang

Journal: Mol Cell

PubMed ID: 38377993

Doi: 10.1016/j.molcel.2024.01.021

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Characterization of an O-Specific Glycosyltransferase Involved in Flagellin Glycosylation

Authors: Daisuke Fujinami, Ayumi Mizui, Azusa Miyata, Sohei Ito

Journal: ACS Chem Biol

PubMed ID: 38562012

Doi: 10.1021/acschembio.4c00045

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The Role of Fatty Acid Synthase in the Vascular Smooth Muscle Cell to Foam Cell Transition

Authors: Bethany J Bogan, Holly C Williams, Claire M Holden, Vraj Patel, Giji Joseph, Christopher Fierro, Hugo Sepulveda, W Robert Taylor, Amir Rezvan, Alejandra San Martin

Journal: Cells

PubMed ID: 38667273

Doi: 10.3390/cells13080658

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of IGF2 promotes skin wound healing by co-expression analysis

Authors: Xingyan Liu, Ying Teng, Huan Li, Ding Luo, Hongkun Li, Jinghan Shen, Simin Du, Yuyue Zhang, Dali Wang, Jie Jing

Journal: Int Wound J

PubMed ID: 38572823

Doi: 10.1111/iwj.14862

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A Rationally Designed Synthetic Antiviral Peptide Binder Targeting the Receptor-Binding Domain of SARS-CoV-2

Authors: Lalita Mohan Behera, Pulkit Kr Gupta, Manaswini Ghosh, Sucharita Shadangi, Soumendra Rana

Journal: J Phys Chem B

PubMed ID: 38657271

Doi: 10.1021/acs.jpcb.4c00241

Products & Services: Proteins, Expression, Isolation and Analysis

Hypoxic dental pulp stem cells-released succinate promotes osteoclastogenesis and root resorption

Authors: Andi Yang, Jinmeng Wang, Zhiyu Yang, Lulu Wang, Houxuan Li, Lang Lei

Journal: Int J Med Sci

PubMed ID: 38774749

Doi: 10.7150/ijms.94972

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Evolutionary analysis reveals the origin of sodium coupling in glutamate transporters

Authors: Krishna D Reddy, Burha Rasool, Farideh Badichi Akher, Nemanja Kutlešić, Swati Pant, Olga Boudker

Journal: biorxiv

PubMed ID: 38106174

Doi: 10.1101/2023.12.03.569786

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Unlocking the distinctive enzymatic functions of the early plant biomass deconstructive genes in a brown rot fungus by cell-free protein expression

Authors: Jesus D Castaño, Irina V El Khoury, Joshua Goering, James E Evans, Jiwei Zhang

Journal: Appl Environ Microbiol

PubMed ID: 38567954

Doi: 10.1128/aem.00122-24

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Establishment and application of a gold nanoparticle-based immunochromatographic test strip for the detection of avian leukosis virus P27 antigen in egg white samples

Authors: Chunhao Wei, Hua Kuang, Xinxin Xu, Lingling Guo, Aihua Qu, Aihong Wu, Chuanlai Xu, Liqiang Liu

Journal: Analyst

PubMed ID: 38563739

Doi: 10.1039/d4an00180j

Products & Services: Proteins, Expression, Isolation and Analysis

Heterogeneous and Cooperative Rupture of Histidine-Ni Metal-Coordination Bonds on Rationally Designed Protein Templates

Authors: Eesha Khare, Constancio Gonzalez Obeso, Zaira Martín-Moldes, Ayesha Talib, David L Kaplan, Niels Holten-Andersen, Kerstin G Blank, Markus J Buehler

Journal: ACS Biomater Sci Eng

PubMed ID: 38669114

Doi: 10.1021/acsbiomaterials.3c01819

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Seroevidence of SARS-CoV-2 spillback to rodents in Sarawak, Malaysian Borneo

Authors: Cheng Siang Tan, Madinah Adrus, Sultana Parvin Habeebur Rahman, Haziq Izzuddin Muhamad Azman, Riz Anasthasia Alta Abang

Journal: BMC Vet Res

PubMed ID: 38678268

Doi: 10.1186/s12917-024-03892-5

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FGF7 enhances the expression of ACE2 in human islet organoids aggravating SARS-CoV-2 infection

Authors: Hao Meng, Zhiying Liao, Yanting Ji, Dong Wang, Yang Han, Chaolin Huang, Xujuan Hu, Jingyi Chen, Hengrui Zhang, Zonghong Li, Changliang Wang, Hui Sun, Jiaqi Sun, Lihua Chen, Jiaxiang Yin, Jincun Zhao, Tao Xu, Huisheng Liu

Journal: Signal Transduct Target Ther

PubMed ID: 38654010

Doi: 10.1038/s41392-024-01790-8

Products & Services: Proteins, Expression, Isolation and Analysis

The impact of glycosylation on the structure, function, and interactions of CD14

Authors: Jon Imanol Quintana, Sandra Delgado, Miriam Rábano, Mikel Azkargorta, Mirane Florencio-Zabaleta, Luca Unione, Maria dM Vivanco, Félix Elortza, Jesús Jiménez-Barbero, Ana Ardá

Journal: Glycobiology

PubMed ID: 38227775

Doi: 10.1093/glycob/cwae002

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Protocol to identify flavonoid antagonists of the SARS-CoV-2 main protease

Authors: Moua Yang, Lin Lin, Robert Flaumenhaft

Journal: STAR Protoc

PubMed ID: 38583157

Doi: 10.1016/j.xpro.2024.102990

Products & Services: Proteins, Expression, Isolation and Analysis

Engineered Luminescent Oncolytic Vaccinia Virus Activation of Photodynamic-Immune Combination Therapy for Colorectal Cancer

Authors: Lu-Yi Ye, Yi-Shu Li, Tong Ge, Long-Cai Liu, Jing-Xing Si, Xue Yang, Wei-Jiao Fan, Xiao-Zhen Liu, You-Ni Zhang, Jun-Wei Wang, Shi-Bing Wang, Hai Zou, Yue-Liang Zheng, Ke-Tao Jin, Zheng-Wei Mao, Yu Cai, Xiao-Zhou Mou

Journal: Adv Healthc Mater

PubMed ID: 38551143

Doi: 10.1002/adhm.202304136

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The Y locus encodes a REPRESSOR OF PHOTOSYNTHETIC GENES protein that represses carotenoid biosynthesis via interaction with APRR2 in carrot

Authors: Ying-Gang Wang, Yu-Min Zhang, Ya-Hui Wang, Kai Zhang, Jing Ma, Jia-Xin Hang, Yu-Ting Su, Shan-Shan Tan, Hui Liu, Ai-Sheng Xiong, Zhi-Sheng Xu

Journal: Plant Cell

PubMed ID: 38593056

Doi: 10.1093/plcell/koae111

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Recombinant bivalent subunit vaccine combining truncated VP4 from P[7] and P[23] induces protective immunity against prevalent porcine rotaviruses

Authors: Xuechao Tang, Sufen Li, Jinzhu Zhou, Xianyu Bian, Jianxin Wang, Nan Han, Xuejiao Zhu, Ran Tao, Wei Wang, Min Sun, Peng Li, Xuehan Zhang, Bin Li

Journal: J Virol

PubMed ID: 38591886

Doi: 10.1128/jvi.00212-24

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