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Dual-responsive nanocarriers for efficient cytosolic protein delivery and CRISPR-Cas9 gene therapy of inflammatory skin disorders

Authors: Echuan Tan, Tao Wan, Qi Pan, Jianan Duan, Song Zhang, Ruijue Wang, Peng Gao, Jia Lv, Hui Wang, Dali Li, Yuan Ping, Yiyun Cheng

Journal: SCIENCE ADVANCES

PubMed ID: 38630829

Doi: 10.1126/sciadv.adl4336

Streptococcus pneumoniae endopeptidase O induces trained immunity and confers protection against various pathogenic infections

Authors: Wenlong Xu, Yuan Yuan, Zhaoche Shu, Ting Guo, Bichen Liu, Jiangming Xiao, Lian Li, Yibin Yin, Xuemei Zhang

Journal: Clin Immunol

PubMed ID: 38663493

Doi: 10.1016/j.clim.2024.110226

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P66 is a bacterial mimic of CD47 that binds the anti-phagocytic receptor SIRPα and facilitates macrophage evasion by

Authors: Michal Caspi Tal, Paige S Hansen, Haley A Ogasawara, Qingying Feng, Regan F Volk, Brandon Lee, Sara E Casebeer, Grace S Blacker, Maia Shoham, Sarah D Galloway, Anne L Sapiro, Beth Hayes, Laughing Bear Torrez Dulgeroff, Tal Raveh, Venkata Raveendra Pothineni, Hari-Hara Sk Potula, Jayakumar Rajadas, Effie E Bastounis, Seemay Chou, William H Robinson, Jenifer Coburn, Irving L Weissman, Balyn W Zaro

Journal: biorxiv

PubMed ID: 38746193

Doi: 10.1101/2024.04.29.591704

Products & Services: Proteins, Expression, Isolation and Analysis

Regulation by the RNA-binding protein Unkempt at its effector interface

Authors: Kriti Shah, Shiyang He, David J Turner, Joshua Corbo, Khadija Rebbani, Daniel Dominguez, Joseph M Bateman, Sihem Cheloufi, Cátia Igreja, Eugene Valkov, Jernej Murn

Journal: Nat Commun

PubMed ID: 38605040

Doi: 10.1038/s41467-024-47449-4

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Author Correction: Fuzzy recognition by the prokaryotic transcription factor HigA2 from Vibrio cholerae

Authors: San Hadži, Zala Živič, Matic Kovačič, Uroš Zavrtanik, Sarah Haesaerts, Daniel Charlier, Janez Plavec, Alexander N Volkov, Jurij Lah, Remy Loris

Journal: Nat Commun

PubMed ID: 38664458

Doi: 10.1038/s41467-024-47946-6

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A selective Fibroblast Growth Factor Receptor 1/2 PROTAC degrader with 1 antitumor activity

Authors: Ying Kong , Xinyue Zhao , Zhaofu Wang , Siqi Yuan , Sheng Chen , Shidi Lou , Shichao Ma , Yunfeng Li , Xinghao Wang , Yangfeng Ge , Guobin Li , Hongbing Yang , Mengxi Zhao , Dandan Li , Hailong Zhang , Wenfu Tan , Juan Wang

Journal: Molecular cancer therapeutics

PubMed ID: 38647531

Doi: 10.1158/1535-7163.MCT-23-0719

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Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system

Authors: Lijie Guo, Pingping Huang, Zhaoxing Li, Young-Cheul Shin, Purui Yan, Meiling Lu, Meirong Chen, Yibei Xiao

Journal: Nat Chem Biol

PubMed ID: 37932527

Doi: 10.1038/s41589-023-01478-0

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Ferroptosis and HMGB2 induced calreticulin translocation required for immunogenic cell death are controlled by the nuclear exporter XPO1

Authors: Ian Blair, Jingqi Fan, Kevin Gillespie, Clementina Mesaros

Journal: Res Sq

PubMed ID: 38496553

Doi: 10.21203/rs.3.rs-4009459/v1

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Validation for the function of protein C in mouse models

Authors: Ya Liu, Maoping Cai, Yan Chen, Guocai Wu, Songyu Li, Zhanghui Chen

Journal: PeerJ

PubMed ID: 38680896

Doi: 10.7717/peerj.17261

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Protein localization of aquaporins in the adult female disease vector mosquito,

Authors: Britney Picinic, Jean-Paul V Paluzzi, Andrew Donini

Journal: Front Insect Sci

PubMed ID: 38699443

Doi: 10.3389/finsc.2024.1365651

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Transmembrane conformation of the envelope protein of an alpha coronavirus, NL63

Authors: Iva Sučec, Yanina Pankratova, Mriganka Parasar, Mei Hong

Journal: Protein Sci

PubMed ID: 38501465

Doi: 10.1002/pro.4923

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FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy

Authors: Jack D Chan, Christina M Scheffler, Isabelle Munoz, Kevin Sek, Joel N Lee, Yu-Kuan Huang, Kah Min Yap, Nicole Y L Saw, Jasmine Li, Amanda X Y Chen, Cheok Weng Chan, Emily B Derrick, Kirsten L Todd, Junming Tong, Phoebe A Dunbar, Jiawen Li, Thang X Hoang, Maria N de Menezes, Emma V Petley, Joelle S Kim, Dat Nguyen, Patrick S K Leung, Joan So, Christian Deguit, Joe Zhu, Imran G House, Lev M Kats, Andrew M Scott, Benjamin J Solomon, Simon J Harrison, Jane Oliaro, Ian A Parish, Kylie M Quinn, Paul J Neeson, Clare Y Slaney, Junyun Lai, Paul A Beavis, Phillip K Darcy

Journal: Nature

PubMed ID: 38600376

Doi: 10.1038/s41586-024-07242-1

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Stepwise activation of a metabotropic glutamate receptor

Authors: Kaavya Krishna Kumar, Haoqing Wang, Chris Habrian, Naomi R Latorraca, Jun Xu, Evan S O'Brien, Chensong Zhang, Elizabeth Montabana, Antoine Koehl, Susan Marqusee, Ehud Y Isacoff, Brian K Kobilka

Journal: Nature

PubMed ID: 38632403

Doi: 10.1038/s41586-024-07327-x

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Development of a latex agglutination test based on VH antibody fragment for detection of Streptococcus suis serotype 2

Authors: Kiratika Chidkoksung, Nattihda Parakasikron, Suphachai Nuanualsuwan, Kannika Khantasup

Journal: PLoS ONE

PubMed ID: 38568909

Doi: 10.1371/journal.pone.0299691

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Biophysical characterization and insights into the oligomeric nature of CD2-associated protein

Authors: Abrar H Qadri, Jyotsana Prajapati, Iqball Faheem, Utsa Bhattacharjee, Hari Krishnan Padmanaban, Sandeep Kn Mulukala, Anil K Pasupulati

Journal: Int J Biochem Mol Biol

PubMed ID: 38765876

Doi: 10.62347/UVSH8436

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Artemisinin Confers Cytoprotection toward Hydrogen Peroxide-Induced Cell Apoptosis in Retinal Pigment Epithelial Cells in Correlation with the Increased Acetylation of Histone H4 at Lysine 8

Authors: Chao Yang, Lijun Ge, Xiyong Yu, Philip Lazarovici, Wenhua Zheng

Journal: Molecules

PubMed ID: 38675608

Doi: 10.3390/molecules29081789

Products & Services: Proteins, Expression, Isolation and Analysis

Antibacterial and Hemolytic Activity of Antimicrobial Hydrogels Utilizing Immobilized Antimicrobial Peptides

Authors: Edvin Blomstrand, Elin Posch, Annija Stepulane, Anand K Rajasekharan, Martin Andersson

Journal: Int J Mol Sci

PubMed ID: 38673786

Doi: 10.3390/ijms25084200

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Injectable self-assembled GDF5-containing dipeptide hydrogels for enhanced tendon repair

Authors: Ming Zhang, Hao Wang, Guan-Chun Dai, Pan-Pan Lu, Yu-Cheng Gao, Mu-Ming Cao, Ying-Juan Li, Yun-Feng Rui

Journal: Mater Today Bio

PubMed ID: 38600922

Doi: 10.1016/j.mtbio.2024.101046

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A measles-vectored vaccine candidate expressing prefusion-stabilized SARS-CoV-2 spike protein brought to phase I/II clinical trials: protection of African green monkeys from COVID-19 disease

Authors: Sham Nambulli, Nicolas Escriou, Linda J Rennick, Matthew J Demers, Natasha L Tilston-Lunel, Anita K McElroy, Dominique J Barbeau, Nicholas A Crossland, Ryan M Hoehl, Sabrina Schrauf, Alexander G White, H Jacob Borish, Jaime A Tomko, Lonnie J Frye, Charles A Scanga, JoAnne L Flynn, Annette Martin, Christiane Gerke, Amy L Hartman, W Paul Duprex

Journal: J Virol

PubMed ID: 38563762

Doi: 10.1128/jvi.01762-23

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Targeting the heparan sulfate-binding site of RAGE with monoclonal antibodies

Authors: Chihyean Ong, Miaomiao Li, Ding Xu

Journal: Glycobiology

PubMed ID: 38181393

Doi: 10.1093/glycob/cwae001

Products & Services: Proteins, Expression, Isolation and Analysis

Deciphering S100B Allosteric Signaling: The Role of a Peptide Target, TRTK-12, as an Ensemble Modulator

Authors: Riya Samanta, Xinhao Zhuang, Kristen M Varney, David J Weber, Silvina Matysiak

Journal: J Chem Inf Model

PubMed ID: 38605537

Doi: 10.1021/acs.jcim.4c00116

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Blocking group 2 innate lymphoid cell activation and macrophage M2 polarization: potential therapeutic mechanisms in ovalbumin-induced allergic asthma by calycosin

Authors: Chunyan Tian, Qi Liu, Xiaoyu Zhang, Zhuying Li

Journal: BMC Pharmacol Toxicol

PubMed ID: 38650035

Doi: 10.1186/s40360-024-00751-9

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The grapevine miR827a regulates the synthesis of stilbenes by targeting VqMYB14 and gives rise to susceptibility in plant immunity

Authors: Yangyang Luo, Linxia Wang, Jie Zhu, Jingwen Tian, Lin You, Qin Luo, Jia Li, Qian Yao, Dong Duan

Journal: Theor Appl Genet

PubMed ID: 38582777

Doi: 10.1007/s00122-024-04599-9

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mARC1 in MASLD: Modulation of lipid accumulation in human hepatocytes and adipocytes

Authors: Amanda K Jones, Besnik Bajrami, Morgan K Campbell, Abdullah Mesut Erzurumluoglu, Qiusha Guo, Hongxing Chen, Xiaomei Zhang, Svetlana Zeveleva, David Kvaskoff, Andreas-David Brunner, Stefanie Muller, Vasudha Gathey, Rajvee M Dave, James W Tanner, Sophia Rixen, Michel A Struwe, Kathryn Phoenix, Kaitlyn J Klumph, Heather Robinson, Daniel Veyel, Annkatrin Muller, Boris Noyvert, Boris Alexander Bartholdy, Agnes A Steixner-Kumar, Jan Stutzki, Dmitriy Drichel, Steffen Omland, Ryan Sheehan, Jon Hill, Tom Bretschneider, Dirk Gottschling, Axel J Scheidig, Bernd Clement, Martin Giera, Zhihao Ding, John Broadwater, Curtis R Warren

Journal: Hepatol Commun

PubMed ID: 38619429

Doi: 10.1097/HC9.0000000000000365

Products & Services: Molecular Biology Reagents

Characterization of genital chlamydia trachomatis infection among women attending infertility and gynecology clinics in Hunan, China

Authors: Qianting Zhou, Jiayan Li, Lipei Luo, Shuling Min, Li Wang, Lixiu Peng, Yinglan Hou, Ping He, Song He, Shixing Tang, Hongliang Chen

Journal: BMC Infect Dis

PubMed ID: 38622501

Doi: 10.1186/s12879-024-09254-8

Products & Services: Proteins, Expression, Isolation and Analysis

Cryo-EM structure of the human Asc-1 transporter complex

Authors: Yaning Li , Yingying Guo, Angelika Bröer, Lu Dai, Stefan Brӧer , Renhong Yan

Journal: Nat Commun

PubMed ID: 38589439

Doi: 10.1038/s41467-024-47468-1

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Developing Plant Exosomes as an Advanced Delivery System for Cosmetic Peptide

Authors: Jiali Hou, Wei Wei, Zaijun Geng, Zhenxing Zhang, Hui Yang, Xuhui Zhang, Li Li, Qi Gao

Journal: ACS Appl Bio Mater

PubMed ID: 38598772

Doi: 10.1021/acsabm.4c00096

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in Ticks Blood-Feeding on Migratory Birds in Sweden

Authors: Peter Wilhelmsson, Malin Lager, Thomas G T Jaenson, Jonas Waldenström, Björn Olsen, Per-Eric Lindgren

Journal: Microorganisms

PubMed ID: 38674679

Doi: 10.3390/microorganisms12040735

Products & Services: Molecular Biology Reagents

Gene replacement therapy in Bietti crystalline corneoretinal dystrophy: an open-label, single-arm, exploratory trial

Authors: Jinyuan Wang, Jinlu Zhang, Shicheng Yu, Hongyan Li, Shaohong Chen, Jingting Luo, Haibo Wang, Yuxia Guan, Haihan Zhang, Shiyi Yin, Huili Wang, Heping Li, Junle Liu, Jingyuan Zhu, Qiong Yang, Ying Sha, Chuan Zhang, Yuhang Yang, Xuan Yang, Xifang Zhang, Xiuli Zhao, Likun Wang, Liping Yang, Wenbin Wei

Journal: Signal Transduct Target Ther

PubMed ID: 38653979

Doi: 10.1038/s41392-024-01806-3

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Co-clustering of EphB6 and ephrinB1 in trans restrains cancer cell invasion

Authors: Lung-Yu Liang, Niall D Geoghegan, Michael Mlodzianoski, Andrew Leis, Lachlan W Whitehead, Minglyanna G Surudoi, Samuel N Young, Peter Janes, Doulin Shepherd, Debnath Ghosal, Kelly L Rogers, James M Murphy, Isabelle S Lucet

Journal: Commun Biol

PubMed ID: 38627519

Doi: 10.1038/s42003-024-06118-4

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Mutation of the peptide-regulated transcription factor ComR for amidated peptide specificity and heterologous function in WCFS1

Authors: Michael Brasino, Eli Wagnell, E Sila Ozdemir, Srivathsan Ranganathan, Justin Merritt

Journal: Microbiol Spectr

PubMed ID: 38687019

Doi: 10.1128/spectrum.00517-24

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The SARS-CoV-2 Spike Protein Receptor-Binding Domain Expressed in Rice Callus Features a Homogeneous Mix of Complex-Type Glycans

Authors: Guillermo Sobrino-Mengual, Victoria Armario-Nájera, Juliette Balieu, Marie-Laure Walet-Balieu, Andrea Saba-Mayoral, Ana M Pelacho, Teresa Capell, Paul Christou, Muriel Bardor, Patrice Lerouge

Journal: Int J Mol Sci

PubMed ID: 38674051

Doi: 10.3390/ijms25084466

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Higher correlation between neutralizing antibodies and surrogate neutralizing or binding antibodies in COVID-19 patients than vaccine recipients

Authors: Hatairat Lerdsamran, Ratikorn Anusorntanawat, Kantima Sangsiriwut, Suteema Sawadpongpan, Jarunee Prasertsopon, Nattakarn Thinpan, Poj Intalapaporn, Ranida Techasuwanna, Pilailuk Okada, Pilaipan Puthavathana

Journal: PLoS ONE

PubMed ID: 38626137

Doi: 10.1371/journal.pone.0298033

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Catalytic specificity and crystal structure of cystathionine γ-lyase from Pseudomonas aeruginosa

Authors: Marco Pedretti, Carmen Fernández-Rodríguez, Carolina Conter, Iker Oyenarte, Filippo Favretto, Adele di Matteo, Paola Dominici, Maria Petrosino, Maria Luz Martinez-Chantar, Tomas Majtan, Alessandra Astegno, Luis Alfonso Martínez-Cruz

Journal: Sci Rep

PubMed ID: 38654065

Doi: 10.1038/s41598-024-57625-7

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Correlates of protection against symptomatic SARS-CoV-2 in vaccinated children

Authors: Youjia Zhong, Alicia Y H Kang, Carina J X Tay, Hui' En Li, Nurul Elyana, Chee Wah Tan, Wee Chee Yap, Joey M E Lim, Nina Le Bert, Kuan Rong Chan, Eugenia Z Ong, Jenny G Low, Lynette P Shek, Elizabeth Huiwen Tham, Eng Eong Ooi

Journal: Nat Med

PubMed ID: 38689059

Doi: 10.1038/s41591-024-02962-3

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Identification and structural characterization of small molecule inhibitors of PINK1

Authors: Shafqat Rasool, Tara Shomali, Luc Truong, Nathalie Croteau, Simon Veyron, Bernardo A Bustillos, Wolfdieter Springer, Fabienne C Fiesel, Jean-François Trempe

Journal: Sci Rep

PubMed ID: 38565869

Doi: 10.1038/s41598-024-58285-3

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Evolutionarily conserved ovarian fluid proteins are responsible for extending egg viability in salmonid fish

Authors: Aurélie Gueho, Daniel Żarski, Hélène Rime, Blandine Guével, Emmanuelle Com, Régis Lavigne, Thaovi Nguyen, Jérôme Montfort, Charles Pineau, Julien Bobe

Journal: Sci Rep

PubMed ID: 38671194

Doi: 10.1038/s41598-024-60118-2

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A cAMP-biosensor-based assay for measuring plasma arginine-vasopressin levels

Authors: Kosuke Doi, Kouki Kawakami, Tatsuya Ikuta, Asuka Inoue

Journal: Sci Rep

PubMed ID: 38658606

Doi: 10.1038/s41598-024-60035-4

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Coordination of actin plus-end dynamics by IQGAP1, formin, and capping protein

Authors: Morgan L Pimm, Brian K Haarer, Alexander D Nobles, Laura M Haney, Alexandra G Marcin, Jessica L Henty-Ridilla

Journal: biorxiv

PubMed ID: 37205555

Doi: 10.1101/2023.05.04.539490

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Distinguishing individual photobodies using Oligopaints reveals thermo-sensitive and -insensitive phytochrome B condensation at distinct subnuclear locations

Authors: Juan Du, Keunhwa Kim, Meng Chen

Journal: Nat Commun

PubMed ID: 38684657

Doi: 10.1038/s41467-024-47789-1

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MCT4 and CD147 colocalize with MMP14 in invadopodia and support matrix degradation and invasion by breast cancer cells

Authors: Signe Meng, Ester E Sørensen, Muthulakshmi Ponniah, Jeppe Thorlacius-Ussing, Roxane Crouigneau, Tanja Larsen, Magnus T Borre, Nicholas Willumsen, Mette Flinck, Stine F Pedersen

Journal: J Cell Sci

PubMed ID: 38661040

Doi: 10.1242/jcs.261608

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Utility of accessible SARS-CoV-2 specific immunoassays in vaccinated adults with a history of advanced HIV infection

Authors: Ludovica Ferrari, Alessandra Ruggiero, Chiara Stefani, Livia Benedetti, Lorenzo Piermatteo, Eleonora Andreassi, Federica Caldara, Drieda Zace, Matteo Pagliari, Francesca Ceccherini-Silberstein, Christopher Jones, Marco Iannetta, Anna Maria Geretti

Journal: Sci Rep

PubMed ID: 38594459

Doi: 10.1038/s41598-024-58597-4

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Probing actin-activated ATP turnover kinetics of human cardiac myosin II by single molecule fluorescence

Authors: Albin Berg, Lok Priya Velayuthan, Sven Tågerud, Marko Ušaj, Alf Månsson

Journal: Cytoskeleton (Hoboken)

PubMed ID: 38623952

Doi: 10.1002/cm.21858

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Improving the Quality of Wheat Flour Bread by a Thermophilic Xylanase with Ultra Activity and Stability Reconstructed by Ancestral Sequence and Computational-Aided Analysis

Authors: Guoshuai Hu, Xizhi Hong, Meixin Zhu, Lei Lei, Zhenggang Han, Yong Meng, Jiangke Yang

Journal: Molecules

PubMed ID: 38675714

Doi: 10.3390/molecules29081895

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Peptide Inhibitor Targeting the Extraterminal Domain in BRD4 Potently Suppresses Breast Cancer Both and

Authors: Qi-Xuan Huang, Da-Meng Fan, Zao-Zao Zheng, Ting Ran, Ao Bai, Rong-Quan Xiao, Guo-Sheng Hu, Wen Liu

Journal: J Med Chem

PubMed ID: 38569135

Doi: 10.1021/acs.jmedchem.4c00141

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Development and performance evaluation of a novel elastic bacterial nanocellulose/polyurethane small caliber artificial blood vessels

Authors: Geli Li, Luhan Bao, Gaoquan Hu, Lin Chen, Xingping Zhou, Feng F Hong

Journal: Int J Biol Macromol

PubMed ID: 38641268

Doi: 10.1016/j.ijbiomac.2024.131685

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A gut microbiota-bile acid axis promotes intestinal homeostasis upon aspirin-mediated damage

Authors: Ting Li, Ning Ding, Hanqing Guo, Rui Hua, Zehao Lin, Huohuan Tian, Yue Yu, Daiming Fan, Zuyi Yuan, Frank J Gonzalez, Yue Wu

Journal: Cell Host & Microbe

PubMed ID: 38237593

Doi: 10.1016/j.chom.2023.12.015

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Energy metabolism as therapeutic target for aged wound repair by engineered extracellular vesicle

Authors: Yu Zhuang , Shengjie Jiang , Xiaoling Deng , An Lao , Xiaolin Hua , Yun Xie , Lingyong Jiang , Xudong Wang , Kaili Lin

Journal: SCIENCE ADVANCES

PubMed ID: 38608014

Doi: 10.1126/sciadv.adl0372

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A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development

Authors: Zhijuan Hu 1, Liang Yang 2, Maolei Zhang 2, Haite Tang 2, Yile Huang 3, Yujie Su 4, Yingzhe Ding 3, Chong Li 2, Mengfei Wang 4, Yunhao Zhou 4, Qing Zhang 5, Liman Guo 5, Yue Wu 5, Qianqian Wang 6, Ning Liu 6, Haoran Kang 2, Yi Wu 2, Deyang Yao 2, Yukun Li 4, Zifeng Ruan 4, Hao Wang 2, Feixiang Bao 2, Guopan Liu 3, Junwei Wang 2, Yaofeng Wang 3, Wuming Wang 7, Gang Lu 7, Dajiang Qin 8, Duanqing Pei 9, Wai-Yee Chan 7, Xingguo Liu

Journal: Cell Metab

PubMed ID: 38703762

Doi: 10.1016/j.cmet.2024.04.012

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A novel engineered IL-21 receptor arms T-cell receptor-engineered T cells (TCR-T cells) against hepatocellular carcinoma

Authors: Wei Zhu, Zhiming Zhang, Jinzhang Chen, Xiaolan Chen, Lei Huang, Xiaoyong Zhang, Xuan Huang, Na Ma, Weikang Xu, Xuan Yi, Xinyu Lu, Xin Fu, Siwei Li, Guoheng Mo, Yiyue Wang, Guosheng Yuan, Mengya Zang, Qi Li, Xiaotao Jiang, Yajing He, Sha Wu, Yukai He, Yongyin Li, Jinlin Hou

Journal: Signal Transduct Target Ther

PubMed ID: 38643203

Doi: 10.1038/s41392-024-01792-6

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