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OGG1 and MUTYH repair activities promote telomeric 8-oxoguanine induced senescence in human fibroblasts

Authors: Mariarosaria De Rosa, Ryan P Barnes, Ariana C Detwiler, Prasanth R Nyalapatla, Peter Wipf, Patricia L Opresko

Journal: Nature Communications

PubMed ID: 39837827

Doi: 10.1038/s41467-024-55638-4

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Self-Cascaded Pyroptosis-STING Initiators for Catalytic Metalloimmunotherapy

Authors: Qiao Yu, Shumin Sun, Nailin Yang, Zifan Pei, Youdong Chen, Jihu Nie, Huali Lei, Li Wang, Fei Gong, Liang Cheng

Journal: Journal of the American Chemical Society

PubMed ID: 39818788

Doi: 10.1021/jacs.4c12552

Products & Services: Protein Electrophoresis and Western

Complement factor H targeting antibody GT103 in refractory non-small cell lung cancer: a phase 1b dose escalation trial

Authors: Jeffrey M. Clarke, George R. Simon, Hirva Mamdani, Lin Gu, James E. Herndon II, Thomas E. Stinchcombe, Neal Ready, Jeffrey Crawford, Guru Sonpavde, Stephen Balevic, Andrew B. Nixon, Michael Campa, Elizabeth B. Gottlin, Huihua Li, Ruchi Saxena, You Wen He, Scott Antonia & Edward F. Patz Jr

Journal: Nature Communications

PubMed ID: 39747856

Doi: 10.1038/s41467-024-55092-2

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Klp2-mediated Rsp1-Mto1 colocalization inhibits microtubule-dependent microtubule assembly in fission yeast

Authors: Lingyun Nie , Wenyue Liu , Zhuobi Liang , Fan Zheng , Xing Liu , Xuebiao Yao , Shengqi Xiang , Kai Jiang , Shengnan Zheng , Chuanhai Fu

Journal: SCIENCE ADVANCES

PubMed ID: 39752482

Doi: 10.1126/sciadv.adq0670

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Large-scale multicenter study reveals anticitrullinated SR-A peptide antibody as a biomarker and exacerbator for rheumatoid arthritis

Authors: by Yang XieChaonan WeiDongdong FuWei ZhangYan DuChuncui HuangShuyan LiuRanran YaoZihao HeShenghua ZhangXu JinBin ShenLulu CaoPing WangXiangyu FangXi ZhengHongying LinXihua WeiWenhao LinMingxin BaiDanxue ZhuYingni LiYamin DingHuaqun ZhuHua YeJing HeYin SuYuan JiaHuaxiang WuYongfu WangDan XingXiaoyan QiuZhanguo LiFanlei Hu

Journal: SCIENCE ADVANCES

PubMed ID: 39752500

Doi: 10.1126/sciadv.adr8078

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Structural insights into the mechanism of phosphate recognition and transport by XPR1

Authors: Wenhui Zhang, Yanke Chen, Zeyuan Guan, Yong Wang, Meng Tang, Zhangmeng Du, Jie Zhang, Meng Cheng, Jiaqi Zuo, Yan Liu, Qiang Wang, Yanjun Liu, Delin Zhang, Ping Yin, Ling Ma & Zhu Liu

Journal: Nature Communications

PubMed ID: 39747008

Doi: 10.1038/s41467-024-55471-9

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Increased SOAT2 expression in aged regulatory T cells is associated with altered cholesterol metabolism and reduced anti-tumor immunity

Authors: Mingjiong Zhang, Jiahua Cui, Haoyan Chen, Yifan Cheng, Qiaoyu Chen, Feng Zong, Xiao Lu, Lang Qin, Yu Han, Xingwang Kuai, Yuxing Zhang, Minjie Chu, Shuangshuang Wu & Jianqing Wu

Journal: Nature Communications

PubMed ID: 39805872

Doi: 10.1038/s41467-025-56002-w

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Multivalent S2 subunit vaccines provide broad protection against Clade 1 sarbecoviruses in female mice

Authors: Peter J. Halfmann, Raj S. Patel, Kathryn Loeffler, Atsuhiro Yasuhara, Lee-Ann Van De Velde, Jie E. Yang, Jordan Chervin, Chloe Troxell, Min Huang, Naiying Zheng, Elizabeth R. Wright, Paul G. Thomas, Patrick C. Wilson, Yoshihiro Kawaoka & Ravi S. Kane

Journal: Nature Communications

PubMed ID: 39774966

Doi: 10.1038/s41467-025-55824-y

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Structural and bioinformatics analyses identify deoxydinucleotide-specific nucleases and their association with genomic islands in gram-positive bacteria

Authors: Sofia Mortensen, Stanislava Kuncová, Justin D Lormand, Tanner M Myers, Soo-Kyoung Kim, Vincent T Lee, Wade C Winkler, Holger Sondermann

Journal: Nucleic Acids Research

PubMed ID: 39778863

Doi: 10.1093/nar/gkae1235

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Recombinant expression systems for production of stabilised virus-like particles as next-generation polio vaccines

Authors: Lee Sherry, Mohammad W. Bahar, Claudine Porta, Helen Fox, Keith Grehan, Veronica Nasta, Helen M. E. Duyvesteyn, Luigi De Colibus, Johanna Marsian, Inga Murdoch, Daniel Ponndorf, Seong-Ryong Kim, Sachin Shah, Sarah Carlyle, Jessica J. Swanson, Sue Matthews, Clare Nicol, George P. Lomonossoff, Andrew J. Macadam, Elizabeth E. Fry, David I. Stuart, Nicola J. Stonehouse & David J. Rowlands

Journal: Nature Communications

PubMed ID: 39827284

Doi: 10.1038/s41467-025-56118-z

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Scale-free Spatio-temporal Correlations in Conformational Fluctuations of Intrinsically Disordered Proteins

Authors: Haoyu Song, Jian Cui, Guorong Hu, Long Xiong, Yanee Wutthinitikornkit, Hai Lei, Jingyuan Li

Journal: Advanced Science

PubMed ID: 39807013

Doi: 10.1002/advs.202412989

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Mismatch prime editing gRNA increased efficiency and reduced indels

Authors: Jidong Fei , Dongdong Zhao , Caiyi Pang , Ju Li , Siwei Li , Wentao Qiao , Juan Tan , Changhao Bi , Xueli Zhang

Journal: Nat Commun

PubMed ID: 39747083

Doi: 10.1038/s41467-024-55578-z

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Systematic functional characterization of non-coding regulatory SNPs associated with central obesity

Authors: Shan-Shan Dong, Yuan-Yuan Duan, Ren-Jie Zhu, Ying-Ying Jia, Jia-Xin Chen, Xiao-Ting Huang, Shi-Hao Tang, Ke Yu, Wei Shi, Xiao-Feng Chen, Feng Jiang, Ruo-Han Hao, Yunlong Liu, Zhongbo Liu, Yan Guo, and Tie-Lin Yang

Journal: The American Journal of Human Genetics

Doi: doi.org/10.1016/j.ajhg.2024.11.005

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Salivary elicitor disulffde isomerase from Nilaparvata lugens targets host rice UDP-glucose epimerase 2 to induce plant defenses

Authors: Jianmei Fu , Zhichang Zhao , Jichao Fang , Rui Ji

Journal: Plant Stress

Doi: doi.org/10.1016/j.stress.2025.100744

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Energy-guided accumulated mutation strategy achieves a highly efficient polyethylene terephthalate-degrading enzyme

Authors: Zhi Wang, Jiaxing Zhang, Shengping You, Rongxin Su, Wei Qi

Journal: Biochemical Engineering Journal

Doi: 10.1016/j.bej.2025.109708

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Discovering CRISPR-Cas system with self-processing pre-crRNA capability by foundation models

Authors: Wenhui Li, Xianyue Jiang, Wuke Wang, Liya Hou, Runze Cai, Yongqian Li, Qiuxi Gu, Qinchang Chen, Peixiang Ma, Jin Tang, Menghao Guo, Guohui Chuai, Xingxu Huang, Jun Zhang, Qi Liu

Journal: Nature Communications

PubMed ID: 39789054

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Regulation of N-degron recognin-mediated autophagy by the SARS-CoV-2 PLpro ubiquitin deconjugase

Authors: Carlos Ayala-Torres , Jiangnan Liu , Nico P Dantuma , Maria G Masucci

Journal: Autophagy

PubMed ID: 39723606

Doi: 10.1080/15548627.2024.2442849

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Hypoxia-tropic delivery of nanozymes targeting transferrin receptor 1 for nasopharyngeal carcinoma radiotherapy sensitization

Authors: Ruofei Zhang, Yanfang Shen, Xiaoying Zhou, Jianru Li, Hanqing Zhao, Zixia Zhang, Jun Zhao, Hongjun Jin, Shuanshuan Guo, Hui Ding, Guohui Nie, Zhe Zhang, Ying Wang, Xiyun Yan & Kelong Fan

Journal: Nature Communications

PubMed ID: 39837820

Doi: 10.1038/s41467-025-56134-z

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Reconstitution of human DNA licensing and the structural and functional analysis of key intermediates

Authors: Jennifer N. Wells, Lucy V. Edwardes, Vera Leber, Shenaz Allyjaun, Matthew Peach, Joshua Tomkins, Antonia Kefala-Stavridi, Sarah V. Faull, Ricardo Aramayo, Carolina M. Pestana, Lepakshi Ranjha & Christian Speck

Journal: Nature Communications

PubMed ID: 39779677

Doi: 10.1038/s41467-024-55772-z

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Engineering a membrane protein chaperone to ameliorate the proteotoxicity of mutant huntingtin

Authors: Jeonghyun Oh, Christy Catherine, Eun Seon Kim, Kwang Wook Min, Hae Chan Jeong, Hyojin Kim, Mijin Kim, Seung Hae Ahn, Nataliia Lukianenko, Min Gu Jo, Hyeon Seok Bak, Sungsu Lim, Yun Kyung Kim, Ho Min Kim, Sung Bae Lee & Hyunju Cho

Journal: Nature Communications

PubMed ID: 39824813

Doi: 10.1038/s41467-025-56030-6

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Coordinated conformational changes in P450 decarboxylases enable hydrocarbons production from renewable feedstocks

Authors: Wesley Cardoso Generoso, Alana Helen Santana Alvarenga, Isabelle Taira Simões, Renan Yuji Miyamoto, Ricardo Rodrigues de Melo, Ederson Paulo Xavier Guilherme, Fernanda Mandelli, Clelton Aparecido Santos, Rafaela Prata, Camila Ramos dos Santos, Felippe Mariano Colombari, Mariana Abrahão Bueno Morais, Rodrigo Pimentel Fernandes, Gabriela Felix Persinoti, Mario Tyago Murakami & Leticia Maria Zanphorlin

Journal: Nature Communications

PubMed ID: 39843428

Doi: 10.1038/s41467-025-56256-4

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Screening the human miRNA interactome reveals coordinated up-regulation in melanoma, adding bidirectional regulation to miRNA networks

Authors: Faezeh Jame-Chenarboo , Joseph N Reyes , Nicholas M Twells , Hoi Hei Ng , Dawn Macdonald , Eva Hernando , Lara K Mahal

Journal: SCIENCE ADVANCES

PubMed ID: 39792681

Doi: 10.1126/sciadv.adr0277

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Dietary amino acids promote glucagon-like hormone release to generate global calcium waves in adipose tissues in Drosophila

Authors: Muhammad Ahmad, Shang Wu, Shengyao Luo, Wenjia Shi, Xuan Guo, Yuansheng Cao, Norbert Perrimon & Li He

Journal: Nature Communications

PubMed ID: 39747032

Doi: 10.1038/s41467-024-55371-y

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MCM2-7 ring closure involves the Mcm5 C-terminus and triggers Mcm4 ATP hydrolysis

Authors: Sarah V. Faull, Marta Barbon, Audrey Mossler, Zuanning Yuan, Lin Bai, L. Maximilian Reuter, Alberto Riera, Christian Winkler, Indiana Magdalou, Matthew Peach, Huilin Li & Christian Speck

Journal: Nature Communications

PubMed ID: 39747125

Doi: 10.1038/s41467-024-55479-1

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Probing SARS-CoV-2 membrane binding peptide via single-molecule AFM-based force spectroscopy

Authors: Qingrong Zhang, Raissa S. L. Rosa, Ankita Ray, Kimberley Durlet, Gol Mohammad Dorrazehi, Rafael C. Bernardi & David Alsteens

Journal: Nature Communications

PubMed ID: 39747000

Doi: 10.1038/s41467-024-55358-9

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f the human autophagy factor EPG5 and the molecular basis of its conserved mode of interaction with Atg8-family proteins

Authors: Yiu Wing Sunny Cheung , Sung-Eun Nam , Gage M J Fairlie , Karlton Scheu , Jennifer M Bui , Hannah R Shariati , Jörg Gsponer , Calvin K Yip

Journal: Autophagy

PubMed ID: 39809444

Doi: 10.1080/15548627.2024.2447213

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Computational design, expression, and characterization of a Plasmodium falciparum multi-epitope, multi-stage vaccine candidate (PfCTMAG)

Authors: Joan A Chick, Nadege N Abongdia, Robert A Shey, Tobias O Apinjoh

Journal: Heliyon

PubMed ID: 39906795

Doi: 10.1016/j.heliyon.2025.e42014

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TET2-mediated ECM1 hypomethylation promotes the neovascularization in active proliferative diabetic retinopathy

Authors: Chunyang Cai, Chufeng Gu, Shuai He, Chunren Meng, Dongwei Lai, Jingfa Zhang, Qinghua Qiu

Journal: Clinical epigenetics

PubMed ID: 38172938

Doi: 10.1186/s13148-023-01619-1

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Developing orthogonal fluorescent RNAs for photoactive dual-color imaging of RNAs in live cells

Authors: Peng Yin , Chunzheng Huang , Li Zhang , Zhenzhen Li , Caijun Zhong , Shi Kuang , Chunyang Lei , Yan Huang , Zhou Nie

Journal: Angew Chem Int Ed Engl

PubMed ID: 39801450

Doi: 10.1002/anie.202424060

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A nanobody-enzyme fusion protein targeting PD-L1 and sialic acid exerts anti-tumor effects by C-type lectin pathway-mediated tumor associated macrophages repolarizing

Authors: Yongliang Tong , Runqiu Chen , Xinrong Lu , Cuiying Chen , Guiqin Sun , Xiaolu Yu , Shaoxian Lyu , Meiqing Feng , Yiru Long , Likun Gong , Li Chen

Journal: Int J Biol Macromol

PubMed ID: 39824395

Doi: 10.1016/j.ijbiomac.2025.139953

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Restoring tumor antigenicity activates the “bystander” T cell immune cycle

Authors: Yifan Yang , Qiumin Yu , Haoyu Zhang , Yuchen Liu , Hexuan Wang , Ningyi Yang , Yulian Shi , Wanli Zhang , Zijie Wu , Shitong Huang , Wenbin Xie , Ran Duan , Qiuli Mao , Xupeiyao Shi , Zheng Gao , Xiaoning Wang , Hanlin Guo , Lingxiao Chen , Yi Han , Ximing Li , Liyuan Chen , Siqi Tang , Ying Fan , Wenbing Yao , Hong Tian , Xiangdong Gao

Journal: J Control Release

PubMed ID: 39894265

Doi: 10.1016/j.jconrel.2025.01.094

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Manganese Galvanic Cells Intervene in Tumor Metabolism to Reinforce cGAS-STING Activation for Bidirectional Synergistic Hydrogen-Immunotherapy

Authors: Nailin Yang , Shumin Sun , Jiachen Xu , Fei Gong, Huali Lei , Yu Hao , Zifan Pei , Chenya Wang , Qiao Yu , Jihu Nie , Nan Jiang , Caifang Ni , Liang Cheng

Journal: Adv Mater

PubMed ID: 10.1002/adma.202414929

Doi: 10.1002/adma.202414929

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Structural dynamics of calcium and integrin-binding protein 2 (CIB2) reveal uncommon flexibility and heterogeneous calcium and magnesium loading

Authors: Gabriele Olivieri, Giuditta Dal Cortivo, Rebecca Del Conte, Serena Zanzoni, Valerio Marino, Daniele Dell'Orco, Francesca Cantini

Journal: International Journal of Biological Macromolecules

PubMed ID: 39586446

Doi: doi.org/10.1016/j.ijbiomac.2024.138003

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Intestine-Decipher Engineered Capsules Protect Against Sepsis-induced Intestinal Injury via Broad-spectrum Anti-inflammation and Parthanatos Inhibition

Authors: Yan Yan, Bin Li, Qiuxia Gao, Miao Wu, Hua Ma, Jiawei Bai, Chengtai Ma, Xinyu Xie, Yuan Gong, Lingqi Xu, Xiaoxue Li, Wei Wang, Yanqiu Wu, Jiamei Wang, Huanhuan Wang, Yi Feng, Yunlong Zhang, Peiran Li, Huimin Shi, Fei Ma, Yue Jia, Han Duan, Xinting Fu, Wenying Wang, Liying Zhan, Xianjin Du, Huiting Zhou, Yuhui Liao

Journal: Advanced Science

PubMed ID: 39836501

Doi: 10.1002/advs.202412799

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Dynamic allostery in the peptide/MHC complex enables TCR neoantigen selectivity

Authors: Jiaqi Ma, Cory M. Ayres, Chad A. Brambley, Smita S. Chandran, Tatiana J. Rosales, W. W. J. Gihan Perera, Bassant Eldaly, William T. Murray, Steven A. Corcelli, Evgenii L. Kovrigin, Christopher A. Klebanoff & Brian M. Baker

Journal: Nature Communications

PubMed ID: 39833157

Doi: 10.1038/s41467-025-56004-8

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Biochemical and structural characterization of Rab3GAP reveals insights into Rab18 nucleotide exchange activity

Authors: Gage M. J. Fairlie, Kha M. Nguyen, Sung-Eun Nam, Alexandria L. Shaw, Matthew A. H. Parson, Hannah R. Shariati, Xinyin Wang, Meredith L. Jenkins, Michael Gong, John E. Burke & Calvin K. Yip

Journal: Nature Communications

PubMed ID: 39779760

Doi: 10.1038/s41467-025-55828-8

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Influenza A Virus H7 nanobody recognizes a conserved immunodominant epitope on hemagglutinin head and confers heterosubtypic protection

Authors: Zhao-Shan Chen, Hsiang-Chi Huang, Xiangkun Wang, Karin Schön, Yane Jia, Michael Lebens, Danica F. Besavilla, Janarthan R. Murti, Yanhong Ji, Aishe A. Sarshad, Guohua Deng, Qiyun Zhu & Davide Angeletti

Journal: Nature Communications

PubMed ID: 39788944

Doi: 10.1038/s41467-024-55193-y

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Interplay between the Xer recombination system and the dissemination of antibioresistance in Acinetobacter baumannii

Authors: Corentin Blanchais, Carine Pages, Manuel Campos, Kenza Boubekeur, Rachel Contarin, Mathias Orlando, Patricia Siguier, Maria-Halima Laaberki, François Cornet, Xavier Charpentier, Philippe Rousseau

Journal: Nucleic Acids Research

PubMed ID: 39777461

Doi: 10.1093/nar/gkae1255

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Identification of a binding site for small molecule inhibitors targeting human TRPM4

Authors: Babatunde Ekundayo, Prakash Arullampalam, Christian E. Gerber, Anne-Flore Hämmerli, Sabrina Guichard, Mey Boukenna, Daniela Ross-Kaschitza, Martin Lochner, Jean-Sebastien Rougier, Henning Stahlberg, Hugues Abriel & Dongchun Ni

Journal: Nature Communications

PubMed ID: 39828793

Doi: 10.1038/s41467-025-56131-2

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Barcoded SARS-CoV-2 viruses define the impact of duration and route of exposure on the transmission bottleneck in a hamster model

Authors: Reed Trende , Tamarand L Darling , Tianyu Gan , David Wang , Adrianus C M Boon

Journal: SCIENCE ADVANCES

PubMed ID: 39813353

Doi: 10.1126/sciadv.ads2927

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Microenvironment actuated CAR T cells improve solid tumor efficacy without toxicity

Authors: Kristen C Vogt , Pedro C Silberman , Qianqian Lin , James E Han , Amy Laflin , Hendryck A Gellineau , Daniel A Heller , David A Scheinberg

Journal: SCIENCE ADVANCES

PubMed ID: 39841845

Doi: 10.1126/sciadv.ads3403

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Direct repeat region 3’ end modifications regulate Cas12a activity and expand its applications

Authors: Wei Zhang , Yinyin Zhong , Jiaqi Wang , Guangrong Zou , Qiaozhen Chen , Chaoxing Liu

Journal: Nucleic Acids Res

PubMed ID: 39883010

Doi: 10.1093/nar/gkaf040

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An Insect Eﬀector Mimics Its Host Immune Regulator to Undermine Plant Immunity

Authors: Jianmei Fu , Shuai Li , Jing Li , Zhichang Zhao , Jing Li , Xinyang Tan , Shan Yu , Maofeng Jing , Keyan Zhu-Salzman , Jichao Fang , Rui Ji

Journal: Adv Sci (Weinh)

PubMed ID: 39853648

Doi: doi.org/10.1002/advs.202409186

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Light signal regulates endoreduplication and tomato fruit expansion through the SlPIF1a-SlTLFP8-SlCDKB2 module

Authors: Jiaojiao Zhang, Jiayi Xu, Xinman Wang, Ying Liu, Shuangtao Li, Jialong Zhang, Lingfeng He, Luqin Guo, Chonghua Li, Xin-Xu Li, Yang-Dong Guo, Na Zhang

Journal: Proceedings of the National Academy of Sciences of the United States of America

PubMed ID: 39847324

Doi: 10.1073/pnas.2404445122

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Evolving antibody response to SARS-CoV-2 antigenic shift from XBB to JN.1

Authors: Fanchong Jian, Jing Wang, Ayijiang Yisimayi, Weiliang Song, Yanli Xu, Xiaosu Chen, Xiao Niu, Sijie Yang, Yuanling Yu, Peng Wang, Haiyan Sun, Lingling Yu, Jing Wang, Yao Wang, Ran An, Wenjing Wang, Miaomiao Ma, Tianhe Xiao, Qingqing Gu, Fei Shao, Youchun Wang, Zhongyang Shen, Ronghua Jin, Yunlong Cao

Journal: Nature

PubMed ID: 39510125

Doi: 10.1038/s41586-024-08315-x

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Divergent evolution of opposite base specificity and single-stranded DNA activity in animal and plant AP endonucleases

Authors: Marina Jordano-Raya, Carol E Schrader, Rafael R Ariza, Teresa Roldán-Arjona, Dolores Córdoba-Cañero

Journal: Nucleic Acids Research

PubMed ID: 39778867

Doi: 10.1093/nar/gkae1297

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Spontaneous base flipping helps drive Nsp15’s preferences in double stranded RNA substrates

Authors: Zoe M. Wright, Kevin John Butay, Juno M. Krahn, Isha M. Wilson, Scott A. Gabel, Eugene F. DeRose, Israa S. Hissein, Jason G. Williams, Mario J. Borgnia, Meredith N. Frazier, Geoffrey A. Mueller & Robin E. Stanley

Journal: Nature Communications

PubMed ID: 39755678

Doi: 10.1038/s41467-024-55682-0

Chemical tools to define and manipulate interferon-inducible Ubl protease USP18

Authors: Griffin J. Davis, Anthony O. Omole, Yejin Jung, Wioletta Rut, Ronald Holewinski, Kiall F. Suazo, Hong-Rae Kim, Mo Yang, Thorkell Andresson, Marcin Drag & Euna Yoo

Journal: Nature Communications

PubMed ID: 39843430

Doi: 10.1038/s41467-025-56336-5

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Nuclear Condensates of WW Domain-Containing Adaptor With Coiled-Coil Regulate Mitophagy via Alternative Splicing

Authors: Jiahe Wang, Yi Fan, Guowen Luo, Liang Xiong, Lijie Wang, Zhuoxuan Wu, Jiayi Wang, Zhengying Peng, Clifford J Rosen, Kefeng Lu, Junjun Jing, Quan Yuan, Zhenwei Zhang, Chenchen Zhou

Journal: Advanced Science

PubMed ID: 39840526

Doi: 10.1002/advs.202406759

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Anti-proteolytic regulation of KRAS by USP9X/NDRG3 in KRAS-driven cancer development

Authors: Han Koo, Kyung Chan Park, Hyun Ahm Sohn, Minho Kang, Dong Joon Kim, Zee-Yong Park, Sehoon Park, Sang Hyun Min, Seong-Hwan Park, Yeon-Mi You, Yohan Han, Bo-Kyung Kim, Chul-Ho Lee, Yeon-Soo Kim, Sang J. Chung, Young Il Yeom & Dong Chul Lee

Journal: Nature Communications

PubMed ID: 39819877

Doi: 10.1038/s41467-024-54476-8

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