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Zinc–Nickel Bimetallic Hydroxide Nanosheets Activate the Paraptosis–Pyroptosis Positive Feedback Cycle for Enhanced Tumor Immunotherapy

Authors: Youdong Chen 1, Yujie Lu , Huali Lei 1, Lin Liu , Xianmin Li 1, Yuqi Yang 1, Shumin Sun 1, Qiao Yu 1, Li Wang 1, Jie Wu 1 2, Jingrui Li 1, Guanghui Hou 1, Liang Cheng

Journal: ACS Nano

PubMed ID: 39404652

Doi: 10.1021/acsnano.4c10378

Products & Services: Protein and Antibody Isolation

SARS-CoV-2 N protein coordinates viral particle assembly through multiple domains

Authors: Yuewen Han 1, Haiwu Zhou 1, Cong Liu 1, Weiwei Wang 1, Yali Qin 2, Mingzhou Chen

Journal: Journal of Virology

PubMed ID: 39412257

Doi: 10.1128/jvi.01036-24

Products & Services: Plasmids for SARS-CoV-2 Detection and Research Gene Synthesis

Single-Dose Physically Cross-Linked Hyaluronic Acid and Lipid Hybrid Nanoparticles Containing Cyclic Guanosine Monophosphate-Adenosine Monophosphate Eliminate Established Tumors

Authors: Jinchao Yu , Xinyan Li , Junyao Li , Nan Sun , Peng Cheng , Jiayi Huang , Sai Li , Rui Kuai

Journal: ACS Nano

PubMed ID: 39418110

Doi: 10.1021/acsnano.4c10673

Products & Services: Recombinant Proteins

Caspase-2 is a condensate-mediated deubiquitinase in protein quality control

Authors: Yingwei Ge , Lijie Zhou, Yesheng Fu , Lijuan He, Yi Chen , Dingchang Li , Yuping Xie , Jun Yang , Haitao Wu, Hongmiao Dai , Zhiqiang Peng , Yong Zhang , Shaoqiong Yi , Bo Wu 1, Xin Zhang, Yangjun Zhang , Wantao Ying 1, Chun-Ping Cui , Cui Hua Liu , Lingqiang Zhang

Journal: Nature Cell Biology

PubMed ID: 39482354

Doi: 10.1038/s41556-024-01522-8

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Online detecting living cells released TNF-α and studying intercellular communication using SuperDNA self-assembled conical nanochannel

Authors: Weiwei Liu , Yu Liu , Zhaoyan Tian , Zhaohan Wang , Hui Liu , Songqin Liu , Yafeng Wu

Journal: Chinese Chemical Letters

Doi: 10.1016/j.cclet.2024.110561

Products & Services: Molecular Biology Reagents

Surface-engineered mesenchymal stem cell for refractory asthma therapy: Reversing airway remodeling

Authors: Xing-Yue He , Meng-Meng Han , Yu-Chen Zhao , Ling Tang , Yi Wang , Lei Xing , Ning Wei , Jing Wang , Guang-Ji Wang , Fang Zhou, Jee-Heon Jeong, Hu-Lin Jiang

Journal: Journal of controlled release

PubMed ID: 39476873

Doi: 10.1016/j.jconrel.2024.10.056

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The E3 Ubiquitin Ligase FBXO38 Maintains the Antitumor Function of Natural Killer Cells by Sustaining IL15R Signaling

Authors: Yongjing Shi , Xiaodong Zheng , Hui Peng , Chenqi Xu , Rui Sun , Zhigang Tian , Haoyu Sun , Xianwei Wang

Journal: Cancer Immunol Res

PubMed ID: 38990095

Doi: 10.1158/2326-6066.CIR-23-1061

Products & Services: Protein and Antibody Isolation

Neddylation and Its Target Cullin 3 Are Essential for Adipocyte Differentiation

Authors: Hongyi Zhou , Vijay Patel , Robert Rice , Richard Lee , Ha Won Kim , Neal L Weintraub , Huabo Su , Weiqin Chen

Journal: Cells

PubMed ID: 39404417

Doi: 10.3390/cells13191654

Products & Services: CRISPR Libraries

Molecular Modeling and In Vitro Functional Analysis of the RGS12 PDZ Domain Variant Associated with High-Penetrance Familial Bipolar Disorder

Authors: Percy S Agogo-Mawuli, Joseph Mendez, Emily A Oestreich, Dustin E Bosch, David P Siderovski

Journal: International Journal of Molecular Sciences

PubMed ID: 39518985

Doi: 10.3390/ijms252111431

Products & Services: Peptide Synthesis Bacterial Expression

Two riboswitch classes that share a common ligand-binding fold show major differences in the ability to accommodate mutations

Authors: Yoshita Srivastava , Olayinka Akinyemi , Tiana C Rohe , Elizabeth M Pritchett , Cameron D Baker , Akshara Sharma , Jermaine L Jenkins , David H Mathews , Joseph E Wedekind

Journal: Nucleic Acids Research

PubMed ID: 39413212

Doi: 10.1093/nar/gkae886

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Disrupting Intracellular Homeostasis by Copper-Based Nanoinducer with Multiple Enzyme-Mimicking Activities to Induce Disulfidptosis-Enhanced Pyroptosis for Tumor Immunotherapy

Authors: Xiao-Kang Jin , Shun-Kang Zhang , Shi-Man Zhang , Jun-Long Liang , Xiao Yan , Yan-Tong Lin , Ran Meng , Zi-Han Xu , Chuan-Jun Liu , Xian-Zheng Zhang

Journal: ADVANCED MATERIALS

PubMed ID: 39468892

Doi: 10.1002/adma.202410957

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The TMEM63B Channel Facilitates Intestinal Motility and Enhances Proliferation of Intestinal Stem Cells

Authors: Jing-Jing Tu , Yan-Yu Zang , Yun Stone Shi ,and Xiao-Yu Teng

Journal: Cells

Doi: doi.org/10.3390/cells13211784

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5′-tRNAGly(GCC) halves generated by IRE1α are linked to the ER stress response

Authors: Hanyong Jin , Ji-Hyun Yeom , Eunkyoung Shin , Yoonjie Ha , Haifeng Liu , Daeyoung Kim , Minju Joo , Yong-Hak Kim , Hak Kyun Kim , Minkyung Ryu, Hong-Man Kim , Jeongkyu Kim , Keun P Kim , Yoonsoo Hahn , Jeehyeon Bae , Kangseok Lee

Journal: Nature Communications

PubMed ID: 39468069

Doi: 10.1038/s41467-024-53624-4

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Zinc oxide nanoparticles with catalase-like nanozyme activity and near-infrared light response: A combination of effective photodynamic therapy, autophagy, ferroptosis, and antitumor immunity

Authors: Jingru Wang , Man Liu , Jingwen Wang , Zhuoyue Li , Zhenhan Feng , Meiqi Xu , Hui Wang , Hui Li , Zhantao Li , Jianming Yu , Junwei Liu , Qingchao Wei , Shuang Zhang , Xuan Zhang

Journal: Acta Pharm Sin B

PubMed ID: 39525585

Doi: 10.1016/j.apsb.2024.07.002

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Acute GARP Depletion Disrupts Vesicle Transport, Leading to Severe Defects in Sorting, Secretion and O-Glycosylation

Authors: Amrita Khakurel , Irina Pokrovskaya , Vladimir V Lupashin

Journal: Traffic

PubMed ID: 39416116

Doi: 10.1111/tra.70003

Products & Services: Protein and Antibody Isolation Gene Synthesis

Retrograde transport of neurotrophin receptor TrkB-FL induced by excitotoxicity regulates Golgi stability and is a target for stroke neuroprotection

Authors: Gema María Esteban-Ortega, Margarita Díaz-Guerra

Journal: biorxiv

Doi: doi.org/10.1101/2024.10.29.620835

Products & Services: Peptide Synthesis Protein and Antibody Isolation

ERK1/2 interaction with DHPS regulates eIF5A deoxyhypusination independently of ERK kinase activity

Authors: Andrew E Becker, Paweł Kochanowski, Pui-Kei Wu, Elżbieta Wątor, Wenjing Chen, Koushik Guchhait, Artur P Biela, Przemysław Grudnik, Jong-In Park

Journal: Cell Reports

PubMed ID: 39392755

Doi: 10.1016/j.celrep.2024.114831

Products & Services: Gene Synthesis

ER-mitochondria distance is a critical parameter for efficient mitochondrial Ca2+ uptake and oxidative metabolism

Authors: Giulia Dematteis, Laura Tapella, Claudio Casali, Maria Talmon, Elisa Tonelli, Simone Reano, Adele Ariotti, Emanuela Pessolano, Justyna Malecka, Gabriela Chrostek, Gabrielė Kulkovienė, Danielius Umbrasas, Carla Distasi, Mariagrazia Grilli, Graham Ladds, Nicoletta Filigheddu, Luigia Grazia Fresu, Katsuhiko Mikoshiba, Carlos Matute, Paula Ramos-Gonzalez, Aiste Jekabsone, Tito Calì, Marisa Brini, Marco Biggiogera, Fabio Cavaliere, Riccardo Miggiano, Armando A Genazzani, Dmitry Lim

Journal: Communications Biology

PubMed ID: 39390051

Doi: 10.1038/s42003-024-06933-9

Products & Services: Gene Synthesis

Delayed reinforcement of costimulation improves the efficacy of mRNA vaccines in mice

Authors: Sarah Sanchez, Tanushree Dangi, Bakare Awakoaiye, Min Han Lew, Nahid Irani, Slim Fourati, Pablo Penaloza-MacMaster

Journal: The journal of clinical investigation

PubMed ID: 39432667

Doi: 10.1172/jci183973

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A novel strategy of co-expressing CXCR5 and IL-7 enhances CAR-T cell effectiveness in osteosarcoma

Authors: Xinhui Hui1†Muhammad Asad Farooq,&#x;Muhammad Asad Farooq1,2†Yiran ChenYiran Chen1Iqra Ajmal,Iqra Ajmal1,2Yaojun Ren,Yaojun Ren1,3Min XueMin Xue1Yuzhou JiYuzhou Ji1Bingtan DuBingtan Du1Shijia WuShijia Wu1Wenzheng Jiang*&#x;Wenzheng Jiang1*‡

Journal: Frontiers in Immunology

Doi: doi.org/10.3389/fimmu.2024.1462076

Products & Services: Nucleic Acid Purification

AtPRMT3-RPS2B promotes ribosome biogenesis and coordinates growth and cold adaptation trade-off

Authors: Zhen Wang , Xiaofan Zhang , Chunyan Liu , Susan Duncan , Runlai Hang , Jing Sun , Lilan Luo , Yiliang Ding , Xiaofeng Cao

Journal: Nature Communications

PubMed ID: 39375381

Doi: 10.1038/s41467-024-52945-8

Products & Services: Protein and Antibody Isolation

Controlled TPCA-1 delivery engineers a pro-tenogenic niche to initiate tendon regeneration by targeting IKKβ/NF-κB signaling

Authors: Jialin Chen , Renwang Sheng , Qingyun Mo , Ludvig J Backman , Zhiyuan Lu , Qiuzi Long , Zhixuan Chen , Zhicheng Cao , Yanan Zhang , Chuanquan Liu , Haotian Zheng , Yu Qi , Mumin Cao , Yunfeng Rui , Wei Zhang

Journal: Bioact Mater

PubMed ID: 39512422

Doi: 10.1016/j.bioactmat.2024.10.016

Products & Services: Recombinant Proteins

Bitter taste receptor TAS2R14 activation and G protein assembly by an intracellular agonist

Authors: Lele Tao , Dongxue Wang , Qingning Yuan Fenghui Zhao , Yu Zhang , Tianyuan Du , Shiyi Shen , H Eric Xu , Yi Li , Dehua Yang , Jia Duan

Journal: Cell Research

PubMed ID: 38969802

Doi: 10.1038/s41422-024-00995-4

Products & Services: Catalog Peptides

Mechanism of nucleosomal H2A K13/15 monoubiquitination and adjacent dual monoubiquitination by RNF168

Authors: Huasong Ai , Zebin Tong , Zhiheng Deng , Qiang Shi, Shixian Tao , Gaoge Sun, Jiawei Liang , Maoshen Sun , Xiangwei Wu , Qingyun Zheng , Lujun Liang , Hang Yin , Jia-Bin Li , Shuai Gao , Changlin Tian , Lei Liu , Man Pan

Journal: Nature Chemical Biology

PubMed ID: 39394267

Doi: doi.org/10.1038/s41589-024-01750-x

Products & Services: Gene Synthesis Molecular Biology Reagents

Natural SNP Variation in GbOSM1 Promotor Enhances Verticillium Wilt Resistance in Cotton

Authors: Guilin Wang, Dayong Zhang , Haitang Wang , Jinmin Kong , Zhiguo Chen , Chaofeng Ruan , Chaoyang Deng , Qihang Zheng , Zhan Guo , Hanqiao Liu, Weixi Li , Xinyu Wang , Wangzhen Guo

Journal: Advanced Science

PubMed ID: 39413014

Doi: 10.1002/advs.202406522

Products & Services: Protein and Antibody Isolation

4-aminopyridine attenuates inflammation and apoptosis and increases angiogenesis to promote skin regeneration following a burn injury in mice

Authors: Rahul V G , Govindaraj Ellur , Amir A Gaber , Prem Kumar Govindappa , John C Elfar

Journal: Cell Death Discov

PubMed ID: 39366954

Doi: 10.1038/s41420-024-02199-6

Products & Services: Protein and Antibody Isolation

Vaccination generates functional progenitor tumor-specific CD8 T cells and long-term tumor control

Authors: Carlos R Detrés Román, Megan M Erwin, Michael W Rudloff, Frank Revetta, Kristen A Murray, Natalie R Favret, Jessica J Roetman, Joseph T Roland, Mary K Washington, Mary Philip

Journal: J Immunother Cancer

PubMed ID: 39362791

Doi: 10.1136/jitc-2024-009129

Products & Services: Peptide Synthesis

Broad cross neutralizing antibodies against sarbecoviruses generated by SARS-CoV-2 infection and vaccination in humans

Authors: Yabin Hu, Qian Wu, Fangfang Chang, Jing Yang, Xiaoyue Zhang, Qijie Wang, Jun Chen, Shishan Teng, Yongchen Liu, Xingyu Zheng, You Wang, Rui Lu, Dong Pan, Zhanpeng Liu, Fen Liu, Tianyi Xie, Chanfeng Wu, Yinggen Tang, Fei Tang, Jun Qian, Hongying Chen, Wenpei Liu, Yi-Ping Li, Xiaowang Qu

Journal: npj Vaccines

PubMed ID: 39438493

Doi: 10.1038/s41541-024-00997-8

Products & Services: Gene Synthesis

Gegen Qinlian Decoction reverses oxaliplatin resistance in colorectal cancer by inhibiting YTHDF1-regulated m6A modification of GLS1

Authors: Xiang Lin , Li Xu , Meng Gu , Huan Shao , Li Yao , Xuan Huang

Journal: Phytomedicine

PubMed ID: 39089089

Doi: 10.1016/j.phymed.2024.155906

Products & Services: Protein Electrophoresis and Western

Targeting Ras-, Rho-, and Rab-family GTPases via a conserved cryptic pocket

Authors: Johannes Morstein , Victoria Bowcut , Micah Fernando , Yue Yang , Lawrence Zhu , Meredith L Jenkins , John T Evans , Keelan Z Guiley , D Matthew Peacock , Sophie Krahnke , Zhi Lin , Katrine A Taran , Benjamin J Huang , Andrew G Stephen , John E Burke , Felice C Lightstone , Kevan M Shokat

Journal: Cell

PubMed ID: 39255801

Doi: 10.1016/j.cell.2024.08.017

Products & Services: DNA Sequencing

Accelerated discovery and miniaturization of novel single-stranded cytidine deaminases

Authors: Jiacheng Deng,† , Xueyuan Li,† , Hao Yu,† , Lin Yang1, Ziru Wang1, Wenfeng Yi, Ying Liu, Wenyu Xiao, Hongyong Xiang, Zicong Xie, Dongmei Lv, Hongsheng Ouyang, Daxin Pang, * and Hongming Yuan

Journal: Nucleic Acids Research

PubMed ID: 39271120

Doi: doi.org/10.1093/nar/gkae800

Products & Services: Gene Synthesis

Rational design of a DNA-launched live attenuated vaccine against human enterovirus 71

Authors: Rong-Rong Zhang 1, Meng-Jiao He 1, Chao Zhou 1, Yan-Peng Xu 1, Wei Tang 1, Tian-Shu Cao 1, Zheng-Jian Wang , Mei Wu , Tao Ming , Yi-Jiao Huang , Meng-Xu Sun , Hui Zhao , Yong-Qiang Deng , Xiao-Feng Li , Bin Wang , Qing Ye , Cheng-Feng Qin

Journal: VIROLOGICA SINICA

PubMed ID: 39306193

Doi: 10.1016/j.virs.2024.09.008

Products & Services: Peptide Tools

Crystal structure and nucleic acid binding mode of CPV NSP9: implications for viroplasm in Reovirales

Authors: Yeda Wang , Hangtian Guo , Yuhao Lu , Wanbin Yang , Tinghan Li , Xiaoyun Ji

Journal: Nucleic Acids Research

PubMed ID: 39287123

Doi: doi.org/10.1093/nar/gkae803

Products & Services: Gene Synthesis

Efficient circularization of protein-encoding RNAs via a novel cis-splicing system

Authors: Shaojun Qi , Huiming Wang , Guopeng Liu , Qianshan Qin , Peng Gao , Bo Ying

Journal: Nucleic Acids Research

PubMed ID: 39162233

Doi: 10.1093/nar/gkae711

Products & Services: Gene Synthesis

Intein splicing efficiency and RadA levels can control the mode of archaeal DNA replication

Authors: Geraldy L S Liman , Christopher W Lennon , Jaylin L Mandley , Alina M Galyon , Kelly M Zatopek , Andrew F Gardner , Thomas J Santangelo

Journal: SCIENCE ADVANCES

PubMed ID: 39292776

Doi: 10.1126/sciadv.adp4995

Products & Services: Gene Synthesis Mutagenesis Services

Orientia tsutsugamushi Ank5 promotes NLRC5 cytoplasmic retention and degradation to inhibit MHC class I expression

Authors: Haley E Adcox , Jason R Hunt , Paige E Allen , Thomas E Siff , Kyle G Rodino , Andrew K Ottens , Jason A Carlyon

Journal: Nature Communications

PubMed ID: 39277599

Doi: 10.1038/s41467-024-52119-6

Products & Services: Custom Vector Construction Codon Optimization

Far-red light photoacclimation in a desert Chroococcidiopsis strain with a reduced FaRLiP gene cluster and expression of its chlorophyll f synthase in space-resistant isolates

Authors: Giorgia di Stefano, Mariano Battistuzzi, Nicoletta La Rocca, Vera M Selinger, Dennis J Nürnberg, Daniela Billi

Journal: Frontiers in microbiology

PubMed ID: 39328908

Doi: 10.3389/fmicb.2024.1450575

Products & Services: Gene Synthesis

In Situ Noninvasive Monitoring of Cell Secretions Based on MOFs/AAO Hybrid Membrane Induced Asymmetric Ion Transport

Authors: Zhaohan Wang , Yafeng Wu , Zhi Wang , Zhaoyan Tian , Yu Liu , Songqin Liu

Journal: Biosensors & bioelectronics

Doi: 10.1016/j.bios.2024.116735

Products & Services: Recombinant Proteins

PICKLE-mediated nucleosome condensing drives H3K27me3 spreading for the inheritance of Polycomb memory during differentiation

Authors: Zhenwei Liang, ∙ Tao Zhu, ∙ Yaoguang Yu,∙ … ∙ Yuhai Cui ∙ Shangzhi Huang ∙ Chenlong Li

Journal: Molecular Cell

Doi: doi.org/10.1016/j.molcel.2024.08.018

Products & Services: Molecular Biology Reagents

Photoexcited Cryptochrome 1 Interacts With SPCHLESS to Regulate Stomatal Development in Arabidopsis

Authors: Li Chen 1 2, Xiaoli Cao , Yupeng Li 1 2, Minqing Liu 1, Yao Liu 1, Yan Guan 1 2, Jiaqi Ruan 1, Zhilei Mao 1 2, Wenxiu Wang 1 2, Hong-Quan Yang 1 2, Tongtong Guo

Journal: PLANT CELL AND ENVIRONMENT

PubMed ID: 39253954

Doi: 10.1111/pce.15123

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Inhalation of Bioorthogonal Gene-Editable Spiky-Pollen Reprograms Tumor-Associated Macrophages for Lung Cancer Immunotherapy

Authors: Qianglan Lu , Ruiyue Chen , Fei Zeng, Zhiyong Liu, Yongchun Pan, Yanfeng Gao, Bangshun He and Yujun Song

Journal: Advanced Functional Materials

Doi: 10.1002/adfm.202408767

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Identification of an RNA-binding perturbing characteristic for thiopurine drugs and their derivatives to disrupt CELF1–RNA interaction

Authors: Yang Tan , Zhibo Zhao , Qingfang Han , Peipei Xu , Xiaopeng Shen , Yajun Jiang , Qiang Xu , Xingxin Wu

Journal: Nucleic Acids Research

PubMed ID: 39268573

Doi: 10.1093/nar/gkae788

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Tuning the fluidity and protein corona of ultrasound-responsive liposomal nanovaccines to program T cell immunity in mice

Authors: Jia He , Chaoyu Wang , Xiao Fang , Junyao Li , Xueying Shen , Junxia Zhang , Cheng Peng , Hongjian Li , Sai Li , Jeffrey M Karp , Rui Kuai

Journal: Nature Communications

PubMed ID: 39284814

Doi: 10.1038/s41467-024-52104-z

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Epitope prime editing shields hematopoietic cells from CD123 immunotherapy for acute myeloid leukemia

Authors: Rui-Jin Ji , Guo-Hua Cao , Wei-Qiang Zhao , Mu-Yao Wang , Pan Gao, Yi-Zhou Zhang, Xue-Bin Wang, Hou-Yuan Qiu , Di-Di Chen, Xiao-Han Tong , Min Duan, Hao Yin, Ying Zhang

Journal: Cell Stem Cell

PubMed ID: 39353428

Doi: 10.1016/j.stem.2024.09.003

Products & Services: Synthetic Guide RNA

Structural characterization of the (deoxy)hypusination in Trichomonas vaginalis questions the bifunctionality of deoxyhypusine synthase

Authors: Elżbieta Wątor, Piotr Wilk, Paweł Kochanowski, Przemysław Grudnik

Journal: FEBS J

Doi: doi.org/10.1111/febs.17207

Products & Services: Gene Synthesis

Pyroptotic-Spatiotemporally Selective Delivery of siRNA against Pyroptosis and Autoimmune Diseases

Authors: Zongyou Pan, Kaiwang Xu, Guanrui Huang, Haoran Hu, Huang Yang, Haotian Shen, Kaijie Qiu, Canlong Wang, Tengjing Xu, Xinning Yu, Jinhua Fang, Jiajie Wang, Yunting Lin, Jiacheng Dai, Yuting Zhong, Hongyun Song, Sunan Zhu, Siheng Wang, Zhuxing Zhou, Chuyue Sun, Zhaopeng Tang, Shiyao Liao, Guang Yang, Zhiyuan You, Xuesong Dai, Zhengwei Mao

Journal: ADVANCED MATERIALS

PubMed ID: 39081086

Doi: 10.1002/adma.202407115

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SARS-CoV-2 ORF10 hijacking ubiquitination machinery reveals potential unique drug targeting sites

Authors: Kaixiang Zhu, Lili Song, Linyue Wang, Lei Hua, Ziyu Luo, Tongyun Wang, Bo Qin, Shuofeng Yuan, Xiaopan Gao, Wenyi Mi, Sheng Cui

Journal: Acta Pharmaceutica Sinica B

PubMed ID: 39309499

Doi: doi.org/10.1016/j.apsb.2024.05.018

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Mitochondrial rewiring with small-molecule drug-free nanoassemblies unleashes anticancer immunity

Authors: Lulu Ren , Jianqin Wan , Xiaoyan Li , Jie Yao , Yan Ma , Fanchao Meng , Shusen Zheng , Weidong Han , Hangxiang Wang