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YAP maintains the dynamics of TDP-43 condensates and antagonizes TDP-43 pathological aggregates

Authors: Jiaqi Zhang, Jiaojiao Hu, Ruogu Liu, Tian Zhou, Xuewei Luo, Peigang Liang, Zaichao Xie, Qinyue Zhao, Yan Chen, Dan Du, Cong Liu, Yiming Zheng, Dan Li, Bo Wang

Journal: Nature Cell Biology

PubMed ID: 40542195

Doi: doi.org/10.1038/s41556-025-01685-y

Products & Services: Protein and Antibody Isolation Protein and Antibody Isolation

RIG-I-Inducing Small Molecules Potently Inhibit HMA-Resistant AML Through Igniting the Overloaded dsRNA Arsenal

Authors: Xueqin Chen 1, Jiaqi Wu 1, Yuntong Li 1, Jiayu Huang 1, Xiangqin Weng 1, Jiale Wu 1, Shujun Xiao 1 2, Huaxin Song 1, Zhengyuan Wang 1, Ni Yan 1, Fangfang Shi 1, Derun Zheng 1 2, Kai Tan 1 2, Hesong Zhang 1, Jingyi Cui 1 2, Wen Wu 1, Wei Wu 3, Sujiang Zhang 1, Min Lu 1

Journal: Advanced Science

PubMed ID: 40568903

Doi: 10.1002/advs.202414477

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Inflammatory macrophage-derived itaconate inhibits DNA demethylase TET2 to prevent excessive osteoclast activation in rheumatoid arthritis

Authors: Kewei Rong, Dezheng Wang, Xiting Pu, Cheng Zhang, Pu Zhang, Xiankun Cao, Jinglin Zheng, Xiao Yang, Kexin Liu, Lei Shi, Yin Li, Peixiang Ma, Dan Ye, Jie Zhao, Pu Wang, An Qin

Journal: Bone Research

PubMed ID: 40500265

Doi: 10.1038/s41413-025-00437-w

Products & Services: Protein and Antibody Isolation

Accurate de novo design of high-affinity protein-binding macrocycles using deep learning

Authors: Stephen A. Rettie; David Juergens; Victor Adebomi; Yensi Flores Bueso; Qinqin Zhao; Alexandria N. Leveille; Andi Liu; Asim K. Bera; Joana A. Wilms; Alina ffing; Alex Kang; Evans Brackenbrough; Mila Lamb; Stacey R. Gerben; Analisa Murray; Paul M. Levine; Maika Schneider; Vibha Vasireddy; Sergey Ovchinnikov; Oliver H. Weiergr ber; Dieter Willbold; Joshua A. Kritzer; Joseph D. Mougous; David Baker; Frank DiMaio; Gaurav Bhardwaj

Journal: Nature Chemical Biology

PubMed ID: 40542165

Doi: 10.1038/s41589-025-01929-w

Itraconazole promotes melanoma cells apoptosis via inhibiting hedgehog signaling pathway-mediated autophagy

Authors: Shunqiao Jin; Xiaojiao Liu; Lingqin Cai; Jiayu Yan; Ling Li; Hongjun Dong; Yuxue Gao; Xicong Zhu; Cong Zhang; Xuezhu Xu

Journal: Frontiers in pharmacology

PubMed ID: 39917616

Doi: 10.3389/fphar.2025.1545243

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Itraconazole promotes melanoma cells apoptosis via inhibiting hedgehog signaling pathway-mediated autophagy

Authors: Shunqiao Jin; Xiaojiao Liu; Lingqin Cai; Jiayu Yan; Ling Li; Hongjun Dong; Yuxue Gao; Xicong Zhu; Cong Zhang; Xuezhu Xu

Journal: Frontiers in pharmacology

PubMed ID: 39917616

Doi: 10.3389/fphar.2025.1545243

Products & Services: Recombinant Proteins

Self-assembled epitope-based nanoparticles targeting the SARS-CoV-2 spike protein enhanced the immune response and induced potential broad neutralizing activity

Authors: Yue Liu; Chenxi Li; Zirui Wu; Yu Zhao; Tieyan Yin; Xiaopan Liu; Jiaru Hui; Qingyu Wang; Yi Pan; Yaming Shan; Xinglong Qu

Journal: Frontiers in cellular and infection microbiology

PubMed ID: 40270771

Doi: 10.3389/fcimb.2025.1560330

Itraconazole promotes melanoma cells apoptosis via inhibiting hedgehog signaling pathway-mediated autophagy

Authors: Shunqiao Jin; Xiaojiao Liu; Lingqin Cai; Jiayu Yan; Ling Li; Hongjun Dong; Yuxue Gao; Xicong Zhu; Cong Zhang; Xuezhu Xu

Journal: Frontiers in pharmacology

PubMed ID: 39917616

Doi: 10.3389/fphar.2025.1545243

Products & Services: Recombinant Proteins

Constitutive down-regulation of liguleless alleles in sorghum drives increased productivity and water use efficiency

Authors: Nikhil Jaikumar, Truyen Quach, Zhengxiang Ge, Natalya Nersesian, Shirley J Sato, Scott M McCoy, Ming Guo, Andrew D B Leakey, Stephen P Long, Tom Elmo Clemente

Journal: Plant Biotechnology Journal.

PubMed ID: 40452217

Doi: 10.1111/pbi.70150

Products & Services: Gene Synthesis

Polymerised superparamagnetic antigen presenting cell lymphocyte capture for enriching tumour reactive T-cells and neoantigen identification

Authors: Chung-Yao Hsu, Po-Cheng Tsai, Jung-Chen Lin, Chen-Hsueh Pai, Yun-Jui Teng, Bing-Yu Yao, Cheng-Yin Fei, Gwo Harn Max Shiau, Leon Cw Lin, Sean Lo, Hung-Chih Yang, Che-Ming Jack Hu

Journal: Nature Communications

PubMed ID: 40456725

Doi: 10.1038/s41467-025-60321-3

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De novo design of protein condensation inhibitors by targeting an allosteric site of cGAS

Authors: Wenfeng Zhao, Guofeng Chen, Jian He, Xiaofang Shen, Muya Xiong, Liwei Xiong, Zhihao Qi, Hang Xie, Wanchen Li, Jiameng Li, Huixia Dou, Hangchen Hu, Haixia Su, Qiang Shao, Minjun Li, Hongbin Sun, Yechun Xu

Journal: Nature Communications

PubMed ID: 40461475

Doi: 10.1038/s41467-025-60297-0

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Substrate-based discovery of α-hydroxycarboxylic acid derivatives as potential herbicides targeting dihydroxyacid dehydratase

Authors: Bo He, Yanhao Hu, Dongshan Liu, Xin Zang, Xu He, Wang Chen, Jingfang Yang, Mingfeng Feng, Ping Chen, Lirong Wei, Yu Li, Wei Yan, Jun Li, Zhike Feng, Jiahai Zhou, Yonghao Ye

Journal: Nature Communications

PubMed ID: 40467578

Doi: 10.1038/s41467-025-60489-8

Functional relocation of the maize chloroplast atpB gene to the nucleus restores photosynthetic competence to a gene-edited non-photosynthetic mutant

Authors: Venkata RamanaRao Mangu, Kelsey Jenkins, Anna Pratt, Kara A Boltz, Leila Pazouki, Alice Y Hui, Muruganantham Mookkan, Jeffrey M Staub

Journal: Plant Biotechnology Journal.

PubMed ID: 40467523

Doi: 10.1111/pbi.70175

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Assembly and the gating mechanism of the Pel exopolysaccharide export complex PelBC of Pseudomonas aeruginosa

Authors: Marius Benedens, Cristian Rosales-Hernandez, Sabine A P Straathof, Jennifer Loschwitz, Otto Berninghausen, Giovanni Maglia, Roland Beckmann, Alexej Kedrov

Journal: Nature Communications

PubMed ID: 40473691

Doi: 10.1038/s41467-025-60605-8

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Single-Cell and Spatial Transcriptomic Profiling of Penile Squamous Cell Carcinoma Reveals Dynamics of Tumor Differentiation and Immune Microenvironment

Authors: Hongjian Song, Zhichao Tong, Guixiang Xie, Yaowei Li, Yubo Zhao, Fengpu Fan, Zongzheng Yang, Qing Shi, Qian Zhang, Feng Wen, Hongxue Meng, Haonan Li, Pengyu Guo, Dayong Hou, Zhenwei Zhang, Zhihao Yin, Ziyi Liu, Jianwei Wang, Peng Zhang, Peng Dai, Changfu Li, Lichen Teng, Yangyang Xu, Dexin Ding, Tao Xu, Jianzhang Li, Yongsheng Chen, Yu Qiu, XiaoWei Hu, Wentao Liu, Liang Wu, Roman Nawroth, Guibo Li, Hang Su, Ziqing Deng, Ziqi Wang, Di Wang, Wanhai Xu

Journal: Advanced Science

PubMed ID: 40470730

Doi: 10.1002/advs.202500216

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Molecular basis of the hepatobiliary tropism of typhoid toxin promoting Salmonella pathogenicity

Authors: Hwa Young Kim, Gi Young Lee, Andrew J Thompson, Ryan McBride, Dah-Jiun Fu, James C Paulson, Jeongmin Song

Journal: SCIENCE ADVANCES

PubMed ID: 40479051

Doi: 10.1126/sciadv.adt2040

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The pioneer transcription factor Zelda facilitates the exit from regeneration and restoration of patterning in Drosophila

Authors: Anish Bose, Keaton Schuster, Chandril Kodali, Surabhi Sonam, Rachel K Smith-Bolton

Journal: SCIENCE ADVANCES

PubMed ID: 40479065

Doi: 10.1126/sciadv.ads5743

Products & Services: PCR Cloning and Subcloning

Chemokines kill bacteria without triggering antimicrobial resistance by binding anionic phospholipids

Authors: Sergio M Pontejo, Sophia Martinez, Allison Zhao, Kevin Barnes, Jaime de Anda, Haleh Alimohamadi, Ernest Y Lee, Acacia F Dishman, Brian F Volkman, Gerard C L Wong, David N Garboczi, Angela Ballesteros, Philip M Murphy

Journal: SCIENCE ADVANCES

PubMed ID: 40479071

Doi: 10.1126/sciadv.ads2675

Products & Services: Plasmid DNA Preparation

ATP13A1 engages SEC61 to facilitate substrate-specific translocation

Authors: Xiaoyan Yang, Yi Li, Chengxi Yang, Tingting Li, Zhiyu Fang, Zhigang Feng, Jun Liao, Yan Zou

Journal: SCIENCE ADVANCES

PubMed ID: 40498833

Doi: 10.1126/sciadv.adt1346

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Synthetic biology-driven induction of mature TLS formation enhances antitumor immunity in colorectal cancer

Authors: Ze Mi, Juan Chen, Zhewen Zhang, Jiahao Liu, Yiyi Lei, Hongpei Tan, Wei Li, Xiaoyuan Chen, Pengfei Rong

Journal: SCIENCE ADVANCES

PubMed ID: 40531967

Doi: 10.1126/scitranslmed.ado8395

Products & Services: DNA Sequencing

HIV-1 binds dynein directly to hijack microtubule transport machinery

Authors: Somayesadat Badieyan, Drew Lichon, Sevnur Komurlu Keceli, Michael P Andreas, John P Gillies, Wang Peng, Jiong Shi, Morgan E DeSantis, Christopher R Aiken, Till Böcking, Tobias W Giessen, Edward M Campbell, Michael A Cianfrocco

Journal: SCIENCE ADVANCES

PubMed ID: 40532013

Doi: 10.1126/sciadv.adn6796

Monoclonal antibodies targeting the FimH adhesin protect against uropathogenic E. coli UTI

Authors: Edward D B Lopatto, Jesús M Santiago-Borges, Denise A Sanick, Sameer Kumar Malladi, Philippe N Azimzadeh, Morgan W Timm, Isabella F Fox, Aaron J Schmitz, Jackson S Turner, Shaza M Sayed Ahmed, Lillian Ortinau, Nathaniel C Gualberto, Jerome S Pinkner, Karen W Dodson, Ali H Ellebedy, Andrew L Kau, Scott J Hultgren

Journal: SCIENCE ADVANCES

PubMed ID: 40540557

Doi: 10.1126/sciadv.adw0698

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Inhalable Artificial Polymeric Nucleases Degrading Neutrophil Extracellular Trap-DNAs and Alleviating Pulmonary Fibrosis

Authors: Yibo Du, Chenxu Zhu, Ruifeng Wang, Shi Chen, Chuang Li, Defang OuYang, Lixin Liu, Yongming Chen

Journal: Advanced Science

PubMed ID: 40539399

Doi: 10.1002/advs.202505357

Lysosomal Cathepsin S Escape Facilitates Near Infrared Light-Triggered Pyroptosis Via an Antibody-Indocyanine Green Conjugate

Authors: Fan Chen, Xue-Fei Tian, Teng Yang, Yu-Jie Dai, Da-Yuan Chen, Hong-Bo Chen, Takaya Shimura, Xin-Fang Li, Chu-Lin Sha, Qing Ji, Jun Cao, Mei-Yu Fang, Jin-Biao Shang, Jian-Min Fang, Ye Lu, Wei-Hui Zheng, Peng Guo, Wei-Hong Tan

Journal: Advanced Science

PubMed ID: 40539828

Doi: 10.1002/advs.202504851

Products & Services: Monoclonal Antibody Services

Topoisomerase I Inhibition in ETV4-overexpressed Non-Small Cell Lung Cancer Promotes Replication and Transcription Mediated R-Loop Accumulation and DNA Damage

Authors: Jiaxi Zhang, Yan Wang, Shanhu Cao, Shelly M Xie, Bei Liu, Yimeng Li, Yuqi Hou, Xue Meng, Mingzhu Ruan, Di Bu, Jia Kang, Ruxin Li, Lei Lou, Juan Wang, Lingxiao Xing

Journal: Advanced Science

PubMed ID: 40548893

Doi: 10.1002/advs.202409307

Products & Services: PCR Cloning and Subcloning

Coordinated early immune response in the lungs is required for effective control of SARS-CoV-2 replication

Authors: Klara Lenart, Hendrik Feuerstein, Mariana Prado Marmorato, Laura Perez Vidakovics, Gerald McInerney, Mimi Guebre-Xabier, Jessica F Trost, Bengt Eriksson, Gale Smith, Nita Patel, Karin Loré

Journal: Nature Communications

PubMed ID: 40562777

Doi: 10.1038/s41467-025-60885-0

Products & Services: Gene Synthesis

Patch-Clamp-like Micropipette Electrode with Exterior and Interior Interfaces for Simultaneous Monitoring of Extracellular and Intracellular Serotonin across Neuron

Authors: Jie Liu, Qin Zhou, Yuandong Liu,Yang Tian

Journal: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Doi: 10.1002/anie.202504408

Products & Services: Gene Synthesis

An Insect Salivary Sheath Protein Triggers Plant Resistance to Insects and Pathogens as a Conserved HAMP

Authors: Liangxuan Qi, Jing Li, Shuai Li, Jing Li, Han Wang, Lei Yang, Xinyang Tan, Zhichang Zhao, Guanghua Luo, Maofeng Jing, Ary A Hoffmann, Jichao Fang, Rui Ji

Journal: Advanced Science

PubMed ID: 40167256

Doi: 10.1002/advs.202415474

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Cathepsin L-dependent positive selection shapes clonal composition and functional fitness of CD4+ T cells

Authors: Elisabetta Petrozziello, Amina Sayed, João A Freitas, Christine Federle, Jelena Nedjic, Sarina Ravens, Batuhan Akçabozan, Anna M Schulz, Dietmar Zehn, Marc Schmidt-Supprian, Reinhard Obst, Immo Prinz, Martijn Verdoes, Jan Kisielow, Thomas Reinheckel, Tobias Straub, Stephen R Daley, Ludger Klein

Journal: nature immunology

PubMed ID: 40514418

Doi: 10.1038/s41590-025-02182-y

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Cholangiocytes contribute to hepatocyte regeneration after partial liver injury during growth spurt in zebrafish

Authors: Sema Elif Eski, Jiarui Mi, Macarena Pozo-Morales, Gabriel Garnik Hovhannisyan, Camille Perazzolo, Rita Manco, Imane Ez-Zammoury, Dev Barbhaya, Anne Lefort, Frédérick Libert, Federico Marini, Esteban N Gurzov, Olov Andersson, Sumeet Pal Singh

Journal: nature COMMUNICATION

PubMed ID: 40480975

Doi: 10.1038/s41467-025-60334-y

Products & Services: Gene Synthesis

Histidine-Specific Modification of Chitin-Binding protein21 via Visible Light-Mediated C–H Functionalization and Protein Ligation

Authors: Xinliang Liu, Ping Wang and Farong Ye

Journal: CCS Chemistry

Doi: 10.31635/ccschem.024.202404864

Products & Services: Gene Synthesis Plasmid DNA Preparation

High throughput cryo-EM provides structural understanding for modulators of the lysosomal ion channel TRPML1

Authors: Judith Reeks, Pravin Mahajan, Mellissa Clark, Suzanna R Cowan, Elena Di Daniel, Christopher P Earl, Samantha Fisher, Rhian S Holvey, Scott M Jackson, Emyr Lloyd-Evans, Carmine M Morgillo, Paul N Mortenson, Marc O'Reilly, Caroline J Richardson, Patrick Schöpf, Daniel M Tams, Helen Waller-Evans, Simon E Ward, Stuart Whibley, Pamela A Williams, Christopher N Johnson

Journal: Structure

PubMed ID: 40532704

Doi: 10.1016/j.str.2025.05.014

Products & Services: Codon Optimization

Host protein ARF1 is a proviral factor for SARS-CoV-2 and a candidate broad-spectrum therapeutic target

Authors: Cunhuan Zhang, Yuan-Qin Min, Heng Xue, Haiyan Zhang, Kunpeng Liu, Yichao Tian, Ziying Yang, Zihan Zhao, Hang Yang, Chao Shan, Xiulian Sun & Yun-Jia Ning

Journal: nature COMMUNICATION

Doi: 10.1038/s41467-025-61431-8

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Synergistic effects of retinol and retinyl palmitate in alleviating UVB-induced DNA damage and promoting the homologous recombination repair in keratinocytes

Authors: Jiangming Zhong; Ling Liang; Nan Zhao; Jing Wang; Peng Shu

Journal: Frontiers in pharmacology

PubMed ID: 40343007

Doi: 10.3389/fphar.2025.1562244

Products & Services: Protein Electrophoresis and Western

A Chemically Induced CRISPR/dCas13 FCPF Platform for Precise and Programmable RNA Regulation

Authors: Sebastian Hasselbeck; Jianhui Wang; Zhaodai Bai; Tobias H fner; Gerhard Hummer; Phillip Grote; Xinlai Cheng

Journal: Journal of Medicinal Chemistry

PubMed ID: 41122778

Doi: 10.1021/acs.jmedchem.5c01609

A yeast-based system to study SARS-CoV-2 M pro structure and to identify nirmatrelvir resistant mutations

Authors: Jin Ou; Eric M. Lewandowski; Yanmei Hu; Austin A. Lipinski; Ryan T. Morgan; Lian M.C. Jacobs; Xiujun Zhang; Melissa J. Bikowitz; Paul Langlais; Haozhou Tan; Jun Wang; Yu Chen; John S. Choy

Journal: research square

PubMed ID: 36052369

Doi: 10.21203/rs.3.rs-1942964/v1

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A rationally designed injury kidney targeting peptide library and its application in rescuing acute kidney injury

Authors: Yushuo Xiao, Zhijian Tong, Huidie Xu, Zhouyan Jia, Chen Wang, Yang Cao, Liangliang Song, Siyu Hao, Jing Yang, Yihao Zhou, Yunhao Xie, Peng Wu, Tong He, Yancai Wu, Robert B Petersen, Anlin Peng, Chun Zhang, Hong Chen, Ling Zheng, Kun Huang

Journal: SCIENCE ADVANCES

PubMed ID: 40315322

Doi: 10.1126/sciadv.adt3943

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Biomimetic culture substrates for modelling homeostatic intestinal epithelium in vitro

Authors: Sorosh Abdollahi, Bahareh Zarin, Maryam Vatani, Fereshteh Vajhadin, Mohsen Hassani, Pezhman Jalali, Keekyoung Kim, Amir Sanati-Nezhad

Journal: Nature Communications

PubMed ID: 40316543

Doi: 10.1038/s41467-025-59459-x

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Structural basis for hepatitis E virus neutralization by potent human antibodies

Authors: Luis M Molinos-Albert, Eduard Baquero, Cyril Planchais, Virginie Doceul, Hicham El Costa, Estelle Mottez, Vincent Mallet, Stanislas Pol, Matthew L Albert, Nicole Pavio, Cécile Alanio, Jordan D Dimitrov, Hugo Mouquet

Journal: SCIENCE ADVANCES

PubMed ID: 40333967

Doi: 10.1126/sciadv.adu8811

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Sickle cell disease induces chromatin introversion and ferroptosis in CD8+ T cells to suppress anti-tumor immunity

Authors: Zilong Zhao, Benxia Hu, Yalan Deng, Melinda Soeung, Jun Yao, Lanxin Bei, Yaohua Zhang, Pengju Gong, Lisa A Huang, Zhou Jiang, Jian Gao, Shuang Peng, Tina K Nguyen, Menuka Karki, Bora Lim, Cassian Yee, Jared K Burks, Qing Zhang, Li Ma, Jianjun Gao, Nizar M Tannir, Leng Han, Dihua Yu, Linghua Wang, Michael A Curran, Maria A Gubbiotti, Giannicola Genovese, Boyi Gan, Wenbo Li, Pavlos Msaouel, Liuqing Yang, Chunru Lin

Journal: Immunity

PubMed ID: 40359940

Doi: 10.1016/j.immuni.2025.04.020

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Import mechanism of peroxisomal proteins with an N-terminal signal sequence

Authors: Michael L Skowyra , Tom A Rapoport

Journal: Nature Cell Biology

PubMed ID: 40346349

Doi: 10.1038/s41556-025-01662-5

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Neuron-targeted gene therapy rescues multiple phenotypes of STXBP1-related disorders in mice and is well tolerated in nonhuman primates

Authors: Rangoli Aeran, Annie Tanenhaus, Sheila M S Sears, Nathan J Moerke, Adam Miller, Camille Artur, Yosr Bouhlal, Peter F Bove, Alexander J Diaz de Arce, Saki Shimizu, Jason Le, Keith Place, Dixon Hoffelt, Tselmeg Amarlkhagva, Jennifer Su, Ming Chen, Brooke A Babineau, John McLaughlin, Myat Soe, Warren Macdonald, I Winnie Lin, Dhruv Bole, Kristen M Valentine, Elizabeth Hallam, Puja Dhanota, Serena Liu, Steven A Tan, Ben Zhao, Raghavendra Hosur, Maria Candida Vila, Suresh Poda, Archana Belle, Stephanie Tagliatela

Journal: Molecular Therapy

PubMed ID: 40349107

Doi: 10.1016/j.ymthe.2025.05.011

TRIM23 mediates cGAS-induced autophagy in anti-HSV defense

Authors: Dhiraj Acharya, Zuberwasim Sayyad, Helene Hoenigsperger, Maximilian Hirschenberger, Matthew Zurenski, Kannan Balakrishnan, Junji Zhu, Sebastian Gableske, Jiro Kato, Shen-Ying Zhang, Jean-Laurent Casanova, Joel Moss, Konstantin M J Sparrer, Michaela U Gack

Journal: Nature Communications

PubMed ID: 40360474

Doi: 10.1038/s41467-025-59338-5

Interleukin-34-dependent perivascular macrophages promote vascular function in the brain

Authors: Hannah Van Hove, Chaim Glück, Wiebke Mildenberger, Ekaterina Petrova, Upasana Maheshwari, Philipp Häne, Victor Kreiner, Mitchell Bijnen, Caroline Mussak, Sebastian G Utz, Jeanne Droux, Florian Ingelfinger, Christian Ashworth, Sebastian A Stifter, Elsa Roussel, Iva Lelios, Marijne Vermeer, Sheng-Fu Huang, Quanyu Zhou, Zhenyue Chen, Charlotte Calvet, Soline Bourgeois, Johanna Schaffenrath, Daniel Razansky, Jean X Juang, Kenichi Asano, Pawel Pelczar, Sarah Mundt, Bruno Weber, Susanne Wegener, Sonia Tugues, Christian Stockmann, Burkhard Becher, Annika Keller, Mohamad El Amki, Melanie Greter

Journal: Immunity

PubMed ID: 40315842

Doi: 10.1016/j.immuni.2025.04.003

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A novel, covalent broad-spectrum inhibitor targeting human coronavirus Mpro

Authors: Jing Sun, Deheng Sun, Qi Yang, Dong Wang, Jingjing Peng, Hu Guo, Xiaoyu Ding, Zhao Chen, Bin Yuan, Yan A Ivanenkov, Jinwei Yuan, Bogdan A Zagribelnyy, Yiyun He, Jingyi Su, Ling Wang, Jielin Tang, Zhun Li, Rong Li, Taotao Li, Xiaoyu Hu, Xing Liang, Airu Zhu, Peilan Wei, Yaya Fan, Sang Liu, Jie Zheng, Xin Guan, Alex Aliper, Minglei Yang, Dmitry S Bezrukov, Zhanhong Xie, Victor A Terentiev, Guilin Peng, Daniil A Polykovskiy, Alexander S Malyshev, Maxim N Malkov, Qingsong Zhu, Alán Aspuru-Guzik, Xiao Ding, Xin Cai, Man Zhang, Jingxian Zhao, Nanshan Zhong, Feng Ren, Xinwen Chen, Alex Zhavoronkov, Jincun Zhao

Journal: Nature Communications

PubMed ID: 40374668

Doi: 10.1038/s41467-025-59870-4

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Hsc70-4: An unanticipated mediator of dsRNA internalization in Drosophila

Authors: Sabrina J Fletcher, Eugenia S Bardossy, Lorena Tomé-Poderti, Thomas Moss, Vanesa Mongelli, Lionel Frangeul, Hervé Blanc, Yann Verdier, Joelle Vinh, Shaeri Mukherjee, Maria-Carla Saleh

Journal: SCIENCE ADVANCES

PubMed ID: 40378201

Doi: 10.1126/sciadv.adv1286

Elucidating the genetic mechanisms governing cytosine base editing outcomes through CRISPRi screens

Authors: Sifeng Gu , Zsolt Bodai , Rachel A Anderson , Hei Yu Annika So , Quinn T Cowan , Alexis C Komor

Journal: Nature Communications

PubMed ID: 40394064

Doi: 10.1038/s41467-025-59948-z

Functional divergence of plant SCAR/WAVE proteins is determined by intrinsically disordered regions

Authors: Sabine Brumm, Aleksandr Gavrin, Matthew Macleod, Guillaume Chesneau, Annika Usländer, Sebastian Schornack

Journal: SCIENCE ADVANCES

PubMed ID: 40397725

Doi: 10.1126/sciadv.adt6107

Products & Services: Gene Synthesis

Graphene oxide enhances aphid resistance in sorghum via the miR319-SbTCP7-SbLOX3 Pathway

Authors: Yannan Shi, Zhiyin Jiao, Jinping Wang, Zhifang Wang, Cheng Chu, Yongchao Guo, Peng Lv, Junfeng Cao

Journal: Plant Biotechnology Journal.

PubMed ID: 40397692

Doi: 10.1111/pbi.70132

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Expanding the σ54-dependent transcription process with orthogonal designs

Authors: Yiheng Liu, Shuyi Cai, Ziyi Zhang, Zhuoting Xie, Chenyue Guo, Yi-Ping Wang, Jianguo Yang

Journal: Nucleic Acids Research

PubMed ID: 40401558

Doi: 10.1093/nar/gkaf442

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