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Somatic and intergenerational G4C2 hexanucleotide repeat instability in a human C9orf72 knock-in mouse model

Authors: Nada Kojak, Junko Kuno, Kristina E Fittipaldi, Ambereen Khan, David Wenger, Michael Glasser, Roberto A Donnianni, Yajun Tang, Jade Zhang, Katie Huling, Roxanne Ally, Alejandro O Mujica, Terrence Turner, Gina Magardino, Pei Yi Huang, Sze Yen Kerk, Gustavo Droguett, Marine Prissette, Jose Rojas, Teodoro Gomez, Anthony Gagliardi, Charleen Hunt, Jeremy S Rabinowitz, Guochun Gong, William Poueymirou, Eric Chiao, Brian Zambrowicz, Chia-Jen Siao, Daisuke Kajimura

Journal: Nucleic Acids Res

PubMed ID: 38597682

Doi: 10.1093/nar/gkae250

Products & Services: PCR Cloning and Subcloning

A hemoprotein with a zinc-mirror heme site ties heme availability to carbon metabolism in cyanobacteria

Authors: Nicolas Grosjean, Estella F Yee, Desigan Kumaran, Kriti Chopra, Macon Abernathy, Sandeep Biswas, James Byrnes, Dale F Kreitler, Jan-Fang Cheng, Agnidipta Ghosh, Steven C Almo, Masakazu Iwai, Krishna K Niyogi, Himadri B Pakrasi, Ritimukta Sarangi, Hubertus van Dam, Lin Yang, Ian K Blaby, Crysten E Blaby-Haas

Journal: Nature Communications

PubMed ID: 38609367

Doi: 10.1038/s41467-024-47486-z

Products & Services: Proteins, Expression, Isolation and Analysis

Human inherited PD-L1 deficiency is clinically and immunologically less severe than PD-1 deficiency

Authors: Matthew B Johnson, Masato Ogishi, Clara Domingo-Vila, Elisa De Franco, Matthew N Wakeling, Zineb Imane, Brittany Resnick, Evangelia Williams, Rui Pedro Galão, Richard Caswell, James Russ-Silsby, Yoann Seeleuthner , Darawan Rinchai, Iris Fagniez, Basilin Benson, Matthew J Dufort, Cate Speake , Megan E Smithmyer, Michelle Hudson, Rebecca Dobbs; EXE-T1D consortium; Zoe Quandt, Andrew T Hattersley ,Peng Zhang, Stephanie Boisson-Dupuis , Mark S Anderson, Jean-Laurent Casanova, Timothy I Tree, Richard A Oram

Journal: Journal Of Experimental Medicine

PubMed ID: 38634869

Doi: 10.1084/jem.20231704

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Targeting branched N-glycans and fucosylation sensitizes ovarian tumors to immune checkpoint blockade

Authors: Hao Nie, Pratima Saini, Taito Miyamoto, Liping Liao, Rafal J Zielinski, Heng Liu, Wei Zhou, Chen Wang, Brennah Murphy, Martina Towers, Tyler Yang, Yuan Qi, Toshitha Kannan, Andrew Kossenkov, Hiroaki Tateno, Daniel T Claiborne, Nan Zhang, Mohamed Abdel-Mohsen, Rugang Zhang

Journal: Nature Communications

PubMed ID: 38565883

Doi: 10.1038/s41467-024-47069-y

Products & Services: Gene Synthesis

Ferroptosis and HMGB2 induced calreticulin translocation required for immunogenic cell death are controlled by the nuclear exporter XPO1

Authors: Ian Blair, Jingqi Fan, Kevin Gillespie, Clementina Mesaros

Journal: Res Sq

PubMed ID: 38496553

Doi: 10.21203/rs.3.rs-4009459/v1

Products & Services: Molecular Biology Reagents

Validation for the function of protein C in mouse models

Authors: Ya Liu, Maoping Cai, Yan Chen, Guocai Wu, Songyu Li, Zhanghui Chen

Journal: PeerJ

PubMed ID: 38680896

Doi: 10.7717/peerj.17261

Products & Services: DNA Sequencing

Protein localization of aquaporins in the adult female disease vector mosquito,

Authors: Britney Picinic, Jean-Paul V Paluzzi, Andrew Donini

Journal: Front Insect Sci

PubMed ID: 38699443

Doi: 10.3389/finsc.2024.1365651

Products & Services: Polyclonal Antibody Services

Transmembrane conformation of the envelope protein of an alpha coronavirus, NL63

Authors: Iva Sučec, Yanina Pankratova, Mriganka Parasar, Mei Hong

Journal: Protein Sci

PubMed ID: 38501465

Doi: 10.1002/pro.4923

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FOXO1 enhances CAR T cell stemness, metabolic fitness and efficacy

Authors: Jack D Chan, Christina M Scheffler, Isabelle Munoz, Kevin Sek, Joel N Lee, Yu-Kuan Huang, Kah Min Yap, Nicole Y L Saw, Jasmine Li, Amanda X Y Chen, Cheok Weng Chan, Emily B Derrick, Kirsten L Todd, Junming Tong, Phoebe A Dunbar, Jiawen Li, Thang X Hoang, Maria N de Menezes, Emma V Petley, Joelle S Kim, Dat Nguyen, Patrick S K Leung, Joan So, Christian Deguit, Joe Zhu, Imran G House, Lev M Kats, Andrew M Scott, Benjamin J Solomon, Simon J Harrison, Jane Oliaro, Ian A Parish, Kylie M Quinn, Paul J Neeson, Clare Y Slaney, Junyun Lai, Paul A Beavis, Phillip K Darcy

Journal: Nature

PubMed ID: 38600376

Doi: 10.1038/s41586-024-07242-1

Products & Services: Molecular Biology Reagents

Stepwise activation of a metabotropic glutamate receptor

Authors: Kaavya Krishna Kumar, Haoqing Wang, Chris Habrian, Naomi R Latorraca, Jun Xu, Evan S O'Brien, Chensong Zhang, Elizabeth Montabana, Antoine Koehl, Susan Marqusee, Ehud Y Isacoff, Brian K Kobilka

Journal: Nature

PubMed ID: 38632403

Doi: 10.1038/s41586-024-07327-x

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Development of a latex agglutination test based on VH antibody fragment for detection of Streptococcus suis serotype 2

Authors: Kiratika Chidkoksung, Nattihda Parakasikron, Suphachai Nuanualsuwan, Kannika Khantasup

Journal: PLoS ONE

PubMed ID: 38568909

Doi: 10.1371/journal.pone.0299691

Products & Services: Molecular Biology Reagents

Biophysical characterization and insights into the oligomeric nature of CD2-associated protein

Authors: Abrar H Qadri, Jyotsana Prajapati, Iqball Faheem, Utsa Bhattacharjee, Hari Krishnan Padmanaban, Sandeep Kn Mulukala, Anil K Pasupulati

Journal: Int J Biochem Mol Biol

PubMed ID: 38765876

Doi: 10.62347/UVSH8436

Products & Services: Molecular Biology Reagents

Artemisinin Confers Cytoprotection toward Hydrogen Peroxide-Induced Cell Apoptosis in Retinal Pigment Epithelial Cells in Correlation with the Increased Acetylation of Histone H4 at Lysine 8

Authors: Chao Yang, Lijun Ge, Xiyong Yu, Philip Lazarovici, Wenhua Zheng

Journal: Molecules

PubMed ID: 38675608

Doi: 10.3390/molecules29081789

Products & Services: Proteins, Expression, Isolation and Analysis

Antibacterial and Hemolytic Activity of Antimicrobial Hydrogels Utilizing Immobilized Antimicrobial Peptides

Authors: Edvin Blomstrand, Elin Posch, Annija Stepulane, Anand K Rajasekharan, Martin Andersson

Journal: Int J Mol Sci

PubMed ID: 38673786

Doi: 10.3390/ijms25084200

Products & Services: Catalog Peptides

Injectable self-assembled GDF5-containing dipeptide hydrogels for enhanced tendon repair

Authors: Ming Zhang, Hao Wang, Guan-Chun Dai, Pan-Pan Lu, Yu-Cheng Gao, Mu-Ming Cao, Ying-Juan Li, Yun-Feng Rui

Journal: Mater Today Bio

PubMed ID: 38600922

Doi: 10.1016/j.mtbio.2024.101046

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A measles-vectored vaccine candidate expressing prefusion-stabilized SARS-CoV-2 spike protein brought to phase I/II clinical trials: protection of African green monkeys from COVID-19 disease

Authors: Sham Nambulli, Nicolas Escriou, Linda J Rennick, Matthew J Demers, Natasha L Tilston-Lunel, Anita K McElroy, Dominique J Barbeau, Nicholas A Crossland, Ryan M Hoehl, Sabrina Schrauf, Alexander G White, H Jacob Borish, Jaime A Tomko, Lonnie J Frye, Charles A Scanga, JoAnne L Flynn, Annette Martin, Christiane Gerke, Amy L Hartman, W Paul Duprex

Journal: J Virol

PubMed ID: 38563762

Doi: 10.1128/jvi.01762-23

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Targeting the heparan sulfate-binding site of RAGE with monoclonal antibodies

Authors: Chihyean Ong, Miaomiao Li, Ding Xu

Journal: Glycobiology

PubMed ID: 38181393

Doi: 10.1093/glycob/cwae001

Products & Services: Proteins, Expression, Isolation and Analysis

Deciphering S100B Allosteric Signaling: The Role of a Peptide Target, TRTK-12, as an Ensemble Modulator

Authors: Riya Samanta, Xinhao Zhuang, Kristen M Varney, David J Weber, Silvina Matysiak

Journal: J Chem Inf Model

PubMed ID: 38605537

Doi: 10.1021/acs.jcim.4c00116

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Blocking group 2 innate lymphoid cell activation and macrophage M2 polarization: potential therapeutic mechanisms in ovalbumin-induced allergic asthma by calycosin

Authors: Chunyan Tian, Qi Liu, Xiaoyu Zhang, Zhuying Li

Journal: BMC Pharmacol Toxicol

PubMed ID: 38650035

Doi: 10.1186/s40360-024-00751-9

Products & Services: Gene Synthesis

The grapevine miR827a regulates the synthesis of stilbenes by targeting VqMYB14 and gives rise to susceptibility in plant immunity

Authors: Yangyang Luo, Linxia Wang, Jie Zhu, Jingwen Tian, Lin You, Qin Luo, Jia Li, Qian Yao, Dong Duan

Journal: Theor Appl Genet

PubMed ID: 38582777

Doi: 10.1007/s00122-024-04599-9

Products & Services: Custom Vector Construction

mARC1 in MASLD: Modulation of lipid accumulation in human hepatocytes and adipocytes

Authors: Amanda K Jones, Besnik Bajrami, Morgan K Campbell, Abdullah Mesut Erzurumluoglu, Qiusha Guo, Hongxing Chen, Xiaomei Zhang, Svetlana Zeveleva, David Kvaskoff, Andreas-David Brunner, Stefanie Muller, Vasudha Gathey, Rajvee M Dave, James W Tanner, Sophia Rixen, Michel A Struwe, Kathryn Phoenix, Kaitlyn J Klumph, Heather Robinson, Daniel Veyel, Annkatrin Muller, Boris Noyvert, Boris Alexander Bartholdy, Agnes A Steixner-Kumar, Jan Stutzki, Dmitriy Drichel, Steffen Omland, Ryan Sheehan, Jon Hill, Tom Bretschneider, Dirk Gottschling, Axel J Scheidig, Bernd Clement, Martin Giera, Zhihao Ding, John Broadwater, Curtis R Warren

Journal: Hepatol Commun

PubMed ID: 38619429

Doi: 10.1097/HC9.0000000000000365

Products & Services: Molecular Biology Reagents

Characterization of genital chlamydia trachomatis infection among women attending infertility and gynecology clinics in Hunan, China

Authors: Qianting Zhou, Jiayan Li, Lipei Luo, Shuling Min, Li Wang, Lixiu Peng, Yinglan Hou, Ping He, Song He, Shixing Tang, Hongliang Chen

Journal: BMC Infect Dis

PubMed ID: 38622501

Doi: 10.1186/s12879-024-09254-8

Products & Services: Proteins, Expression, Isolation and Analysis

Measles Virus-Based Vaccine Expressing Membrane-Anchored Spike of SARS-CoV-2 Inducing Efficacious Systemic and Mucosal Humoral Immunity in Hamsters

Authors: Zhi-Hui Yang 1, Yan-Li Song 1, Jie Pei 1, Song-Zhuang Li 1, Rui-Lun Liu 1, Yu Xiong 1, Jie Wu 1, Yuan-Lang Liu 1, Hui-Fen Fan 1, Jia-Hui Wu 1, Ze-Jun Wang 1, Jing Guo 1, Sheng-Li Meng 1, Xiao-Qi Chen 1, Jia Lu 1, Shuo Shen 1

Journal: Viruses

PubMed ID: 38675901

Doi: 10.3390/v16040559

Products & Services: Molecular Biology Reagents

Kirigami-inspired artificial spidroin microneedles for wound patches

Authors: Yongji Xiong, Yue Xu, Baoyang Lin, Bingfang He, Bingbing Gao

Journal: Int J Biol Macromol

PubMed ID: 38663709

Doi: 10.1016/j.ijbiomac.2024.131838

Products & Services: Proteins, Expression, Isolation and Analysis

The Role of Fatty Acid Synthase in the Vascular Smooth Muscle Cell to Foam Cell Transition

Authors: Bethany J Bogan, Holly C Williams, Claire M Holden, Vraj Patel, Giji Joseph, Christopher Fierro, Hugo Sepulveda, W Robert Taylor, Amir Rezvan, Alejandra San Martin

Journal: Cells

PubMed ID: 38667273

Doi: 10.3390/cells13080658

Products & Services: Proteins, Expression, Isolation and Analysis

Identification, Expression and Evolutional Analysis of Two Genes in Amphioxus

Authors: Yajun Wang, Jingyuan Lin, Wenjin Li, Guangdong Ji, Zhenhui Liu

Journal: Animals (Basel)

PubMed ID: 38672288

Doi: 10.3390/ani14081140

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A Rationally Designed Synthetic Antiviral Peptide Binder Targeting the Receptor-Binding Domain of SARS-CoV-2

Authors: Lalita Mohan Behera, Pulkit Kr Gupta, Manaswini Ghosh, Sucharita Shadangi, Soumendra Rana

Journal: J Phys Chem B

PubMed ID: 38657271

Doi: 10.1021/acs.jpcb.4c00241

Products & Services: Proteins, Expression, Isolation and Analysis

Hypoxic dental pulp stem cells-released succinate promotes osteoclastogenesis and root resorption

Authors: Andi Yang, Jinmeng Wang, Zhiyu Yang, Lulu Wang, Houxuan Li, Lang Lei

Journal: Int J Med Sci

PubMed ID: 38774749

Doi: 10.7150/ijms.94972

Products & Services: Gene Synthesis

Identification of IGF2 promotes skin wound healing by co-expression analysis

Authors: Xingyan Liu, Ying Teng, Huan Li, Ding Luo, Hongkun Li, Jinghan Shen, Simin Du, Yuyue Zhang, Dali Wang, Jie Jing

Journal: Int Wound J

PubMed ID: 38572823

Doi: 10.1111/iwj.14862

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Unlocking the distinctive enzymatic functions of the early plant biomass deconstructive genes in a brown rot fungus by cell-free protein expression

Authors: Jesus D Castaño, Irina V El Khoury, Joshua Goering, James E Evans, Jiwei Zhang

Journal: Appl Environ Microbiol

PubMed ID: 38567954

Doi: 10.1128/aem.00122-24

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Establishment and application of a gold nanoparticle-based immunochromatographic test strip for the detection of avian leukosis virus P27 antigen in egg white samples

Authors: Chunhao Wei, Hua Kuang, Xinxin Xu, Lingling Guo, Aihua Qu, Aihong Wu, Chuanlai Xu, Liqiang Liu

Journal: Analyst

PubMed ID: 38563739

Doi: 10.1039/d4an00180j

Products & Services: Proteins, Expression, Isolation and Analysis

Heterogeneous and Cooperative Rupture of Histidine-Ni Metal-Coordination Bonds on Rationally Designed Protein Templates

Authors: Eesha Khare, Constancio Gonzalez Obeso, Zaira Martín-Moldes, Ayesha Talib, David L Kaplan, Niels Holten-Andersen, Kerstin G Blank, Markus J Buehler

Journal: ACS Biomater Sci Eng

PubMed ID: 38669114

Doi: 10.1021/acsbiomaterials.3c01819

Products & Services: Gene Synthesis

Identification and characterization of emGalaseE, a β-1,4 galactosidase from Elizabethkingia meningoseptica, and its application on living cell surface

Authors: Yongliang Tong, Xinrong Lu, Danfeng Shen, Lin Rao, Lin Zou, Shaoxian Lyu, Linlin Hou, Guiqin Sun, Li Chen

Journal: Biological Macromolecules

PubMed ID: 38657932

Doi: 10.1016/j.ijbiomac.2024.131766

Products & Services: Gene Synthesis

Protein language models-assisted optimization of a uracil-N-glycosylase variant enables programmable T-to-G and T-to-C base editing

Authors: Yan He, Xibin Zhou, Chong Chang, Ge Chen, Weikuan Liu, Geng Li, Xiaoqi Fan, Mingsun Sun, Chensi Miao, Qianyue Huang, Yunqing Ma, Fajie Yuan, Xing Chang

Journal: Mol Cell

PubMed ID: 38377993

Doi: 10.1016/j.molcel.2024.01.021

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A rational designed multi-epitope vaccine elicited robust protective efficacy against Klebsiella pneumoniae lung infection

Authors: Jingwen Liao, Xiaoli Zhang, Xi Zeng, Zhuo Zhao, Tianjun Sun, Zhenping Xia, Haiming Jing, Yue Yuan, Zhifu Chen, Qiang Gou, Liqun Zhao, Weijun Zhang, Quanming Zou, Jinyong Zhang

Journal: Biomed Pharmacother

PubMed ID: 38643540

Doi: 10.1016/j.biopha.2024.116611

Products & Services: Molecular Biology Reagents

Characterization of an O-Specific Glycosyltransferase Involved in Flagellin Glycosylation

Authors: Daisuke Fujinami, Ayumi Mizui, Azusa Miyata, Sohei Ito

Journal: ACS Chem Biol

PubMed ID: 38562012

Doi: 10.1021/acschembio.4c00045

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Evolutionary analysis reveals the origin of sodium coupling in glutamate transporters

Authors: Krishna D Reddy, Burha Rasool, Farideh Badichi Akher, Nemanja Kutlešić, Swati Pant, Olga Boudker

Journal: biorxiv

PubMed ID: 38106174

Doi: 10.1101/2023.12.03.569786

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Seroevidence of SARS-CoV-2 spillback to rodents in Sarawak, Malaysian Borneo

Authors: Cheng Siang Tan, Madinah Adrus, Sultana Parvin Habeebur Rahman, Haziq Izzuddin Muhamad Azman, Riz Anasthasia Alta Abang

Journal: BMC Vet Res

PubMed ID: 38678268

Doi: 10.1186/s12917-024-03892-5

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The impact of glycosylation on the structure, function, and interactions of CD14

Authors: Jon Imanol Quintana, Sandra Delgado, Miriam Rábano, Mikel Azkargorta, Mirane Florencio-Zabaleta, Luca Unione, Maria dM Vivanco, Félix Elortza, Jesús Jiménez-Barbero, Ana Ardá

Journal: Glycobiology

PubMed ID: 38227775

Doi: 10.1093/glycob/cwae002

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FGF7 enhances the expression of ACE2 in human islet organoids aggravating SARS-CoV-2 infection

Authors: Hao Meng, Zhiying Liao, Yanting Ji, Dong Wang, Yang Han, Chaolin Huang, Xujuan Hu, Jingyi Chen, Hengrui Zhang, Zonghong Li, Changliang Wang, Hui Sun, Jiaqi Sun, Lihua Chen, Jiaxiang Yin, Jincun Zhao, Tao Xu, Huisheng Liu

Journal: Signal Transduct Target Ther

PubMed ID: 38654010

Doi: 10.1038/s41392-024-01790-8

Products & Services: Proteins, Expression, Isolation and Analysis

Protocol to identify flavonoid antagonists of the SARS-CoV-2 main protease

Authors: Moua Yang, Lin Lin, Robert Flaumenhaft

Journal: STAR Protoc

PubMed ID: 38583157

Doi: 10.1016/j.xpro.2024.102990

Products & Services: Proteins, Expression, Isolation and Analysis

Engineered Luminescent Oncolytic Vaccinia Virus Activation of Photodynamic-Immune Combination Therapy for Colorectal Cancer

Authors: Lu-Yi Ye, Yi-Shu Li, Tong Ge, Long-Cai Liu, Jing-Xing Si, Xue Yang, Wei-Jiao Fan, Xiao-Zhen Liu, You-Ni Zhang, Jun-Wei Wang, Shi-Bing Wang, Hai Zou, Yue-Liang Zheng, Ke-Tao Jin, Zheng-Wei Mao, Yu Cai, Xiao-Zhou Mou

Journal: Adv Healthc Mater

PubMed ID: 38551143

Doi: 10.1002/adhm.202304136

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The Y locus encodes a REPRESSOR OF PHOTOSYNTHETIC GENES protein that represses carotenoid biosynthesis via interaction with APRR2 in carrot

Authors: Ying-Gang Wang, Yu-Min Zhang, Ya-Hui Wang, Kai Zhang, Jing Ma, Jia-Xin Hang, Yu-Ting Su, Shan-Shan Tan, Hui Liu, Ai-Sheng Xiong, Zhi-Sheng Xu

Journal: Plant Cell

PubMed ID: 38593056

Doi: 10.1093/plcell/koae111

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Recombinant bivalent subunit vaccine combining truncated VP4 from P[7] and P[23] induces protective immunity against prevalent porcine rotaviruses

Authors: Xuechao Tang, Sufen Li, Jinzhu Zhou, Xianyu Bian, Jianxin Wang, Nan Han, Xuejiao Zhu, Ran Tao, Wei Wang, Min Sun, Peng Li, Xuehan Zhang, Bin Li

Journal: J Virol

PubMed ID: 38591886

Doi: 10.1128/jvi.00212-24

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Proteolytic cleavage of the TGFβ co-receptor CD109 changes its conformation, resulting in protease inhibition via activation of its thiol ester, and dissociation from the cell membrane

Authors: Kathrine Tejlgård Jensen, Nadia Sukusu Nielsen, Ana Viana Almeida, Ida B Thøgersen, Jan J Enghild, Seandean Lykke Harwood

Journal: FEBS J

PubMed ID: 38587194

Doi: 10.1111/febs.17128

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Ultrastructural localization of Porphyromonas gingivalis gingipains in the substantia nigra of Parkinson's disease brains

Authors: Florian Ermini, Victoria F Low, Jennifer J Song, Adelie Y S Tan, Richard L M Faull, Michael Dragunow, Maurice A Curtis, Stephen S Dominy

Journal: NPJ Parkinsons Dis

PubMed ID: 38664405

Doi: 10.1038/s41531-024-00705-2

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A highly efficient blocking ELISA based on p72 monoclonal antibody for the detection of African swine fever virus antibodies and identification of its linear B cell epitope

Authors: Weldu Tesfagaber, Wan Wang, Lulu Wang, Rui Zhao, Yuanmao Zhu, Fang Li, Encheng Sun, Renqiang Liu, Zhigao Bu, Geng Meng, Dongming Zhao

Journal: Int J Biol Macromol

PubMed ID: 38642684

Doi: 10.1016/j.ijbiomac.2024.131695

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Histone derived antimicrobial peptides identified from Mytilus coruscus serum by peptidomics

Authors: Haodong Wang, Zhi Liao, Zongxin Yang, Wenhui Xiao, Zilin Yang, Jianyu He, Xiaolin Zhang, Xiaojun Yan, Changsheng Tang

Journal: Fish Shellfish Immunol

PubMed ID: 38614412

Doi: 10.1016/j.fsi.2024.109546

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MEF2C contributes to axonal branching by regulating Kif2c transcription

Authors: Ronghua Wu, Ying Sun, Zhihao Zhou, Zhangji Dong, Yan Liu, Mei Liu, Huasong Gao

Journal: Eur J Neurosci

PubMed ID: 38663879

Doi: 10.1111/ejn.16344

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Water-deficit stress induces prenylated stilbenoid production and affects biomass in peanut hairy roots: Exploring the role of stilbenoid prenyltransferase downregulation

Authors: Gaurav Gajurel, Rokib Hasan, Fabricio Medina-Bolivar

Journal: Plant Physiol Biochem

PubMed ID: 38579541

Doi: 10.1016/j.plaphy.2024.108596

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