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Doublet decoding of tRNASer3 demonstrates plasticity of ribosomal decoding center

Authors: Shruthi Krishnaswamy, Shirin Akbar, Daniel S D Larsson, Yang Chen, Maria Selmer

Journal: Nature Communications

PubMed ID: 40571681

Doi: 10.1101/2024.12.14.628468

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Designing Sandwich ELISA with Broadly Reactive Anti-Nucleocapsid Monoclonal Antibodies to Detect Bat-Borne Merbecoviruses

Authors: Kong Yen Liew, Yaju Wang, Sneha Sree Mullapudi, Dinah Binte Aziz, Wenjie Fan, Min Luo, Paul Anantharajah Tambyah, Yee-Joo Tan

Journal: Viruses

PubMed ID: 40733504

Doi: 10.3390/v17070886

Products & Services: Gene Synthesis Codon Optimization PCR Cloning and Subcloning

Mechanism of ATP hydrolysis in the Hsp70 BiP nucleotide-binding domain

Authors: Guillaume Mas , Sebastian Hiller

Journal: Nature Communications

PubMed ID: 40449998

Doi: 10.1038/s41467-025-60343-x

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Structure of bifunctional variediene synthase yields unique insight on biosynthetic diterpene assembly and cyclization

Authors: Eliott S Wenger, David W Christianson

Journal: Nature Communications

PubMed ID: 39677668

Doi: 10.1101/2024.12.03.626647

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Identification and characterisation of vaginal bacteria-glycan interactions implicated in reproductive tract health and pregnancy outcomes

Authors: Virginia Tajadura-Ortega, Wengang Chai, Lauren A Roberts, Yibing Zhang, Antonio Di Maio, Alexiane C Decout, Benedita A Pinheiro, Angelina S Palma, Gian De Nicola, Lucia Riaposova, Belen Gimeno-Molina, Yun S Lee, Hongzhi Cao, Vladimir Piskarev, Yukie Akune, Tiago R D Costa, Himani Amin, Lynne Sykes, Phillip R Bennett, Julian R Marchesi, Ten Feizi, Yan Liu, David A MacIntyre

Journal: Nature Communications

PubMed ID: 40467588

Doi: 10.1038/s41467-025-60404-1

Products & Services: PCR Cloning and Subcloning

Strategy to overcome a nirmatrelvir resistance mechanism in the SARS-CoV-2 nsp5 protease

Authors: Grace Neilsen, Shuiyun Lan, Ryan L Slack, Zachary C Lorson, Andres Emanuelli Castaner, Rachel Lee, Kristin G Edwards, Huanchun Zhang, Jasper Lee, William A Cantara, Maria E Cilento, Hongwang Zhang, Ramyani De, Franck Amblard, Philip R Tedbury, Karen A Kirby, Raymond F Schinazi, Stefan G Sarafianos

Journal: SCIENCE ADVANCES

PubMed ID: 40479048

Doi: 10.1126/sciadv.adv8875

Products & Services: PCR Cloning and Subcloning

RIFINs displayed on malaria-infected erythrocytes bind KIR2DL1 and KIR2DS1

Authors: Akihito Sakoguchi, Samuel G Chamberlain, Alexander M Mørch, Marcus Widdess, Thomas E Harrison, Michael L Dustin, Hisashi Arase, Matthew K Higgins, Shiroh Iwanaga

Journal: Nature

PubMed ID: 40500441

Doi: 10.1038/s41586-025-09091-y

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Dynamic ensembles of SARS-CoV-2 N-protein reveal head-to-head coiled-coil-driven oligomerization and phase separation

Authors: Guillem Hernandez, Maria L Martins, Nuno P Fernandes, Tiago Veloso, João Lopes, Tiago Gomes, Tiago N Cordeiro

Journal: Nucleic Acids Research

PubMed ID: 40503686

Doi: 10.1093/nar/gkaf502

Identification of a gene conferring broad-spectrum orthotospovirus resistance in Solanaceae

Authors: Yong Liu, Jie Wang, Chongkun Zuo, Weishu Fan, Cheng Yuan, Jianmin Zeng, Haiqin Yu, Zhijun Tong, Xueyi Sui, Yi Xu, Min Zhu, Xiaorong Tao, Jiongjiong Chen, Hanhui Kuang, Polina Yu Novikova, Changjun Huang

Journal: SCIENCE ADVANCES

PubMed ID: 40532009

Doi: 10.1126/sciadv.adw4333

Products & Services: Gene Synthesis

In vitro programmable DNA cleavage by a eukaryotic Argonaute

Authors: Guangbo Yan, Xia Li, Longyu Wang, Fei Wang, Siyuan Lv, Xiaolan Yu, Zhongchen Li, Jiakai Cui, Baotong Sun, Jia Hou, Wenqiang Li, Xiaochen Xie, Shuai Zhao, Zhiwei Zhang, Wanping Chen, Yanhong Peng, Yang Liu, Lixin Ma

Journal: Nucleic Acids Research

PubMed ID: 40548933

Doi: 10.1093/nar/gkaf561

UniClo: scarless hierarchical DNA assembly without sequence constraint

Authors: Carol N Flores-Fernández , Da Lin , Katherine Robins , Chris A O'Callaghan

Journal: Nucleic Acids Research

PubMed ID: 40548934

Doi: 10.1093/nar/gkaf548

Products & Services: PCR Cloning and Subcloning

Novel telomere-targeting dual-pharmacophore dinucleotide prodrugs for anticancer therapy

Authors: Ilgen Mender , Romina Girotti , Sergei Gryaznov

Journal: Nucleic Acids Research

PubMed ID: 40568934

Doi: 10.1093/nar/gkaf591

Products & Services: Protein Electrophoresis and Western

Dual-Modular Hydrogel Microparticles with Precision-Modulation of Inflammatory Microenvironment Dictate Full-Thickness Cartilage Regeneration for Osteoarthritis Repair

Authors: Xinye Chen, Yuanman Yu, Zirui He, Lina Pan, Jing Wang, Changsheng Liu

Journal: Advanced Science

Doi: 10.1002/advs.202504965

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And then, proteins were resolved in 4–12% Bis-Tris SurePAGE gel (Genscript) and transferred to 0.45 µm PVDF membrane (Millipore) for blotting.

Authors: Sitao Zhang, Zixuan Jiang, Rundong Huang, Wenting Huang, Siyuan Peng, Shaoxun Mo, Letao Zhu, Peiheng Li, Ziyi Zhang, Emily Pan, Xi Chen, Yunfei Long, Qi Liang, Jin Tang, Renjing Xu, Rui Qing

Journal: Advanced Science

Doi: 10.1002/advs.202502723

Products & Services: Codon Optimization

NIR light-driven transformable liquid metal-based nanovaccines restrain postoperative colorectal cancer recurrence

Authors: Zheng Dai, Feng Liu, Miaodeng Liu, Yuqi Song, Hongyan Zhang, Cheng Zhou, Wenyu Liu, Xiaoqiong Li, Guobin Wang, Lin Wang, Zheng Wang

Journal: Bioactive Materials

Doi: https://doi.org/10.1016/j.bioactmat.2025.06.037

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Targeting Senescent Alveolar Type 2 Cells with a Gene-Editable FePt Dual-Atom Catalyst for Mitigating Idiopathic Pulmonary Fibrosis

Authors: Qianglan Lu, Chengwei Ye, Wei Mao, Fei Zeng, Zhiyong Liu, Ruiyue Chen, Xiao Cheng, Yanfeng Gao, Meng Wang, Mei Liu, Shaochun Tang, Yujun Song

Journal: ACS Nano .

PubMed ID: 40532220

Doi: 10.1021/acsnano.5c04686

Products & Services: CRISPR Libraries

Design and Semisynthesis of Ubiquitin Extension Probes for Structural Analysis of Cullin1-Mediated Substrate Polyubiquitination

Authors: Chuntong Li, Fangyu Zhao, Chong Zuo, Liying Zhang, Yangwode Jing, Xu Li, Guo-Chao Chu, Luyu Shi, Yingyue Zhang, Han Wang, Shuzhe Sun, Maoshen Sun, Huasong Ai, Lu-Jun Liang, Jinghong Li

Journal: Journal of the American Chemical Society

PubMed ID: 40561458

Doi: 10.1021/jacs.5c06399

Products & Services: Gene Synthesis Codon Optimization

Improving diffusion-based protein backbone generation with global-geometry-aware latent encoding

Authors: Yuyang Zhang, Yuhang Liu, Zinnia Ma, Min Li, Chunfu Xu & Haipeng Gong

Journal: Nature Machine Intelligence

Doi: doi.org/10.1038/s42256-025-01059-x

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The Design and Application of Inhibiting Peptide for Rapid In vitro Downregulation of Post-Translational Modifications Levels at a Specific Site

Authors: Shu-Ping Zhang, Jia-Qi Liu, Ning Su, Jie Yang, Zhi-Xia Yang, Dong Zhang, Xian-Zhe Gu

Journal: Journal of visualized experiments:JoVE

PubMed ID: 40622887

Doi: 10.3791/68581

Products & Services: Protein Electrophoresis and Western

Accurate de novo design of high-affinity protein-binding macrocycles using deep learning

Authors: Stephen A. Rettie; David Juergens; Victor Adebomi; Yensi Flores Bueso; Qinqin Zhao; Alexandria N. Leveille; Andi Liu; Asim K. Bera; Joana A. Wilms; Alina ffing; Alex Kang; Evans Brackenbrough; Mila Lamb; Stacey R. Gerben; Analisa Murray; Paul M. Levine; Maika Schneider; Vibha Vasireddy; Sergey Ovchinnikov; Oliver H. Weiergr ber; Dieter Willbold; Joshua A. Kritzer; Joseph D. Mougous; David Baker; Frank DiMaio; Gaurav Bhardwaj

Journal: Nature Chemical Biology

PubMed ID: 40542165

Doi: 10.1038/s41589-025-01929-w

Phosphorylation-inducing chimera rewires oncogenic kinase to trigger apoptosis

Authors: Manuel L. Merz; Veronika M. Shoba; Rajaiah Pergu; Zachary C. Severance; Dhanushka N. P. Munkanatta Godage; Arghya Deb; Hui Si Kwok; Prashant Singh; Sameek Singh; Jonathan B. Allen; Wenzhi Tian; Pallavi M. Gosavi; Santosh K. Chaudhary; Viktoriya Anokhina; Ellen L. Weisberg; N. Connor Payne; Yao He; Reilly Osadchey; Mrinal Shekhar; Ralph Mazitschek; Matthew G. Rees; Jennifer A. Roth; Qiang Cui; James D. Griffin; Brian B. Liau; Amit Choudhary

Journal: biorxiv

PubMed ID: 40661463

Doi: 10.1101/2025.06.13.659082

Products & Services: PCR Cloning and Subcloning

Phosphorylation-inducing chimera rewires oncogenic kinase to trigger apoptosis

Journal: biorxiv

PubMed ID: 40661463

Doi: 10.1101/2025.06.13.659082

Products & Services: PCR Cloning and Subcloning

Self-assembled epitope-based nanoparticles targeting the SARS-CoV-2 spike protein enhanced the immune response and induced potential broad neutralizing activity

Authors: Yue Liu; Chenxi Li; Zirui Wu; Yu Zhao; Tieyan Yin; Xiaopan Liu; Jiaru Hui; Qingyu Wang; Yi Pan; Yaming Shan; Xinglong Qu

Journal: Frontiers in cellular and infection microbiology

PubMed ID: 40270771

Doi: 10.3389/fcimb.2025.1560330

Machine learning-assisted substrate binding pocket engineering based on structural information

Authors: Xinglong Wang; Kangjie Xu; Xuan Zeng; Kai Linghu; Beichen Zhao; Shangyang Yu; Kun Wang; Shuyao Yu; Xinyi Zhao; Weizhu Zeng; Kai Wang; Jingwen Zhou

Journal: BRIEFINGS IN BIOINFORMATICS

PubMed ID: 39101501

Doi: 10.1093/bib/bbae381

Synergistic effects of retinol and retinyl palmitate in alleviating UVB-induced DNA damage and promoting the homologous recombination repair in keratinocytes

Authors: Jiangming Zhong; Ling Liang; Nan Zhao; Jing Wang; Peng Shu

Journal: Frontiers in pharmacology

PubMed ID: 40343007

Doi: 10.3389/fphar.2025.1562244

Products & Services: Protein Electrophoresis and Western

H19 influenza A virus exhibits species-specific MHC-II receptor usage

Authors: Umut Karakus; Ignacio Mena; Jithesh Kottur; Sara S. El Zahed; Roc o Seoane; Soner Yildiz; Leanne Chen; Magdalena Plancarte; LeAnn Lindsay; Rebecca Halpin; Timothy B Stockwell; David E. Wentworth; Geert-Jan Boons; Florian Krammer; Silke Stertz; Walter Boyce; Robert P de Vries; Aneel K Aggarwal; Adolfo Garc a-Sastre

Journal: Cell Host & Microbe

PubMed ID: 38889725

Doi: 10.1016/j.chom.2024.05.018

H19 influenza A virus exhibits species-specific MHC-II receptor usage

Journal: Cell Host & Microbe

PubMed ID: 38889725

Doi: 10.1016/j.chom.2024.05.018

A MERS-CoV-like mink coronavirus uses ACE2 as an entry receptor

Authors: Ningning Wang, Weiwei Ji, Houqi Jiao, Michael Veit, Ju Sun, Yanjun Wang, Xing Ma, Yu Wang, Yutong Wang, Xin-Xin Li, Xiaoguang Zhang, Jie Chen, Jiayu Wei, Ying Xu, Dawei Guo, Xiaofeng Zhai, Andres Merits, Chang Li, Félix A Rey, Georgi M Dobrikov, George F Gao, Shuijun Zhang, Yuhai Bi, Shuo Su

Journal: Nature

PubMed ID: 40306315

Doi: 10.1038/s41586-025-09007-w

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A New Vaccine Candidate Expressing JUNV GP1–GP2 Against Argentine Hemorrhagic Fever Based on Baculovirus Surface Display

Authors: Carla Tomatis, Mara C A M Aguiar, Nancy Charo, Silvia Aquila, Pablo D Thomas, Paula N Arrías, Matías L Pidre, Víctor Romanowski, Laura Riera, Julia Brignone, Andrea Maiza, Eugenio Antonio Carrera Silva, María Florencia Ferrer, Ricardo Martín Gómez

Journal: Current Microbiology

PubMed ID: 40514553

Doi: 10.1007/s00284-025-04320-z

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OsPRMT6b balances plant growth and high temperature stress by feedback inhibition of abscisic acid signaling

Authors: Xin Jin, Qibing Lin, Xinyue Zhang, Shuang Zhang, Weiwei Ma, Peike Sheng, Limin Zhang, Minxi Wu, Xudong Zhu, Zhiwei Li, Bojuan Liu, Jiachang Wang, Yupeng Wang, Kun Dong, Ming Yu, Yulong Ren, Zhijun Cheng, Cailin Lei, Xiuping Guo, Xin Wang, Haiyang Wang, Fu-Qing Wu, Shanshan Zhu, Jianmin Wan

Journal: Nature Communications

PubMed ID: 40467572

Doi: 10.1038/s41467-025-60350-y

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Mechanism of DNA degradation by CBASS Cap5 endonuclease immune effector

Authors: Olga Rechkoblit, Daniela Sciaky, Mi Ni, Yangmei Li, Jithesh Kottur, Gang Fang, Aneel K Aggarwal

Journal: Nature Communications

PubMed ID: 40473611

Doi: 10.1038/s41467-025-60484-z

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β-propeller protein-associated neurodegeneration protein WDR45 regulates stress granule disassembly via phase separation with Caprin-1

Authors: Yin Li, Jie Fang, Yuqi Ding, Xilong Zhang, Ying Liu, Wanting Qiu, He Xu, Yunzhe Kang, Jiayu Chen, Yanyan Gao, Yan G Zhao, Peiguo Yang, Bo Wang, Wenmin Tian, Yang Chen, Wenjian Bi, Peipei Zhang

Journal: Nature Communications

PubMed ID: 40473629

Doi: 10.1038/s41467-025-60583-x

Products & Services: Protein and Antibody Isolation

An Engineered Soluble Single-Chain TCR Engager for KRAS-G12V Specific Tumor Immunotherapy

Authors: Keke Ma, Jie Wang, Min Jiang, Juanhua He, Fangyang Li, Dan Lu, Chao Su, Yan Chai, Wenjing Jin, Yu Chen, Catherine W H Zhang, Xiaopeng Ma, Hui Tan, George F Gao, Shuguang Tan

Journal: Advanced Science

PubMed ID: 40470869

Doi: 10.1002/advs.202500181

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GhTOPP4aD and GhRAF36 inversely regulate cotton (Gossypium hirsutum) response to ABA and salt stress through reversible phosphorylation of GhABI1

Authors: Pengfei Cao, Lin Zhou, Mingwei Du, Xiaoli Tian, Fangjun Li, Zhaohu Li

Journal: Plant Biotechnology Journal.

PubMed ID: 40483577

Doi: 10.1111/pbi.70166

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Deciphering the role of accessory proteins in Arabidopsis chloroplast editosomes via interaction with a synthetic PPR-PLS factor in E. coli

Authors: Jose M Lombana , Maureen R Hanson , Stéphane Bentolila

Journal: Nucleic Acids Research

PubMed ID: 40498070

Doi: 10.1093/nar/gkaf483

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Discovery of FoTO1 and Taxol genes enables biosynthesis of baccatin III

Authors: Conor James McClune, Jack Chun-Ting Liu, Chloe Wick, Ricardo De La Peña, Bernd Markus Lange, Polly M Fordyce, Elizabeth S Sattely

Journal: Nature

PubMed ID: 40500440

Doi: 10.1038/s41586-025-09090-z

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Multiple intramolecular triggers converge to preferential G protein coupling in the CB2R

Authors: Adrian Morales-Pastor, Tamara Miljuš, Miguel Dieguez-Eceolaza, Tomasz Maciej Stępniewski, Vicente Ledesma-Martin, Franziska M Heydenreich, Tilman Flock, Bianca Plouffe, Christian Le Gouill, Jean Duchaine, David A Sykes, Colin Nicholson, Eline J Koers, Wolfgang Guba, Arne C Rufer, Uwe Grether, Michel Bouvier, Dmitry B Veprintsev, Jana Selent

Journal: Nature Communications

PubMed ID: 40500255

Doi: 10.1038/s41467-025-60003-0.

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mRNA-LNP vaccines against hepatitis B virus induce protective immune responses in preventive and chronic mouse challenge models

Authors: María José Limeres, Rocio Gambaro, Malin Svensson, Silvia Fraude-El Ghazi, Leah Pretsch, Daniel Frank, German A Islan, Ignacio Rivero Berti, Matthias Bros, Ying K Tam, Hiromi Muramatsu, Norbert Pardi, Stephan Gehring, Maximiliano L Cacicedo

Journal: Molecular Therapy

PubMed ID: 40518670

Doi: 10.1016/j.ymthe.2025.06.027

ELD1 mediates photoperiodic flowering via OsCCA1 alternative splicing and interacts with phytochrome signaling in rice

Authors: Liang Cai, Benyuan Hao, Zhuang Xu, Song Cui, Qianyun Wu, Jiyoung Lee, Haigang Hou, Yuan Hu, Liang Zhu, Jie Wang, Wen Li, Kongyou Chang, Weihao Shao, Shanshan Zhu, Xiangchao Gan, Chao Li, Ling Jiang, Yunlu Tian, Xi Liu, Shijia Liu, Liangming Chen, Haiyang Wang, Shirong Zhou, Jianmin Wan

Journal: Nature Communications

PubMed ID: 40537466

Doi: 10.1038/s41467-025-60839-6

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Herpes simplex virus type 1 reshapes host chromatin architecture via transcription machinery hijacking

Authors: Esther González-Almela, Alvaro Castells-Garcia, François Le Dily, Manuel Fernández Merino, Davide Carnevali, Pol Cusco, Luciano Di Croce, Maria Pia Cosma

Journal: Nature Communications

PubMed ID: 40537528

Doi: 10.1038/s41467-025-60534-6

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Large-scale experimental assessment of variant effects on the structure and function of the citrate transporter SLC13A5

Authors: Wen-An Wang, Evandro Ferrada, Christoph Klimek, Tanja Osthushenrich, Aidan MacNamara, Tabea Wiedmer, Giulio Superti-Furga

Journal: SCIENCE ADVANCES

PubMed ID: 40577459

Doi: 10.1126/sciadv.adx3011

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Structural Insights into the Assembly of the African Swine Fever Virus Inner Capsid

Authors: Haining Li , Qi Liu , Luyuan Shao , Ye Xiang

Journal: Journal of Virology

PubMed ID: 37191520

Doi: 10.1128/jvi.00268-23

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Enhancement of CRISPR-Cas12a system through universal circular RNA design

Authors: Jiaqi Wang, Wei Zhang, Wentao Li, Qinyuan Xie, Ziyu Zang, Chaoxing Liu

Journal: Cell Reports Methods

PubMed ID: 40527291

Doi: 10.1016/j.crmeth.2025.101076

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YAP maintains the dynamics of TDP-43 condensates and antagonizes TDP-43 pathological aggregates

Authors: Jiaqi Zhang, Jiaojiao Hu, Ruogu Liu, Tian Zhou, Xuewei Luo, Peigang Liang, Zaichao Xie, Qinyue Zhao, Yan Chen, Dan Du, Cong Liu, Yiming Zheng, Dan Li, Bo Wang

Journal: Nature Cell Biology

PubMed ID: 40542195

Doi: doi.org/10.1038/s41556-025-01685-y

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RIG-I-Inducing Small Molecules Potently Inhibit HMA-Resistant AML Through Igniting the Overloaded dsRNA Arsenal

Authors: Xueqin Chen 1, Jiaqi Wu 1, Yuntong Li 1, Jiayu Huang 1, Xiangqin Weng 1, Jiale Wu 1, Shujun Xiao 1 2, Huaxin Song 1, Zhengyuan Wang 1, Ni Yan 1, Fangfang Shi 1, Derun Zheng 1 2, Kai Tan 1 2, Hesong Zhang 1, Jingyi Cui 1 2, Wen Wu 1, Wei Wu 3, Sujiang Zhang 1, Min Lu 1

Journal: Advanced Science

PubMed ID: 40568903

Doi: 10.1002/advs.202414477

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Inflammatory macrophage-derived itaconate inhibits DNA demethylase TET2 to prevent excessive osteoclast activation in rheumatoid arthritis

Authors: Kewei Rong, Dezheng Wang, Xiting Pu, Cheng Zhang, Pu Zhang, Xiankun Cao, Jinglin Zheng, Xiao Yang, Kexin Liu, Lei Shi, Yin Li, Peixiang Ma, Dan Ye, Jie Zhao, Pu Wang, An Qin

Journal: Bone Research

PubMed ID: 40500265

Doi: 10.1038/s41413-025-00437-w

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Synthesis of an E2-Ub-nucleosome conjugate to capture the E3 ligase PHF7-catalyzed H3K14 ubiquitination intermediate

Authors: Shixian Tao, Wei He, Chuntong Li, Jiawei Liang, Zebin Tong, Zhiheng Deng, Liying Zhang, Huasong Ai, Lu-Jun Liang, Lei Liu

Journal: Science China-Chemistry

Doi: 10.1007/s11426-025-2697-6

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Synergistic effects of retinol and retinyl palmitate in alleviating UVB-induced DNA damage and promoting the homologous recombination repair in keratinocytes

Authors: Jiangming Zhong; Ling Liang; Nan Zhao; Jing Wang; Peng Shu

Journal: Frontiers in pharmacology