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Integrative in silico and biochemical analyses demonstrate direct Arl3-mediated ODA16 release from the intraflagellar transport machinery

Authors: Jiaolong Wang, Rune T Kidmose, Niels Boegholm, Nevin K Zacharia, Mads B Thomsen, Anni Christensen, Tara Malik, Karl Lechtreck, Esben Lorentzen

Journal: The Journal of biological chemistry

PubMed ID: 39880089

Doi: 10.1016/j.jbc.2025.108237

Products & Services: Gene Synthesis Codon Optimization

Cell-autonomous innate immunity by proteasome-derived defence peptides

Authors: Karin Goldberg, Arseniy Lobov, Paola Antonello, Merav D Shmueli, Idan Yakir, Tal Weizman, Adi Ulman, Daoud Sheban, Einav Laser, Matthias P Kramer, Ronen Shteinvil, Guoyun Chen, Angham Ibraheem, Vera Sysoeva, Vered Fishbain-Yoskovitz, Gayatree Mohapatra, Anat Abramov, Sandy Shimshi, Kseniia Ogneva, Madhurima Nandy, Sivan Amidror, Hadar Bootz-Maoz, Shanny H Kuo, Nili Dezorella, Assaf Kacen, Aaron Javitt, Gee W Lau, Nissan Yissachar, Zvi Hayouka, Yifat Merbl

Journal: Nature

PubMed ID: 40044870

Doi: 10.1038/s41586-025-08615-w

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Structure and dynamics of GAD65 in complex with an autoimmune polyendocrine syndrome type 2-associated autoantibody

Authors: Susanne H D Ständer, Cyril F Reboul, Sarah N Le, Daniel E Williams, Peter G Chandler, Mauricio G S Costa, David E Hoke, John D T Jimma, James Fodor, Gustavo Fenalti, Stuart I Mannering, Benjamin T Porebski, Peter Schofield, Daniel Christ, Malcolm Buckle, Sheena McGowan, Dominika Elmlund, Kasper D Rand, Ashley M Buckle

Journal: Nature Communications

PubMed ID: 40055307

Doi: 10.1038/s41467-025-57492-4

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Splenic red pulp macrophages eliminate the liver-resistant Streptococcus pneumoniae from the blood circulation of mice

Authors: Haoran An, Yijia Huang, Zhifeng Zhao, Kunpeng Li, Jingjing Meng, Xueting Huang, Xianbin Tian, Hongyu Zhou, Jiamin Wu, Qionghai Dai, Jing-Ren Zhang

Journal: SCIENCE ADVANCES

PubMed ID: 40073120

Doi: 10.1126/sciadv.adq6399

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PNPLA6 regulates retinal homeostasis by choline through phospholipid turnover

Authors: Takashi Ono, Yoshitaka Taketomi, Takayoshi Higashi, Hiroyasu Sato, Chika Mochizuki-Ono, Yuki Nagasaki, Takashi Ueta, Takashi Miyai, Suzumi M Tokuoka, Yoshiya Oda, Yasumasa Nishito, Tomio Ono, Choji Taya, Satoru Arata, Sumiko Watanabe, Tomoyoshi Soga, Tetsuya Hirabayashi, Makoto Aihara, Makoto Murakami

Journal: Nature Communications

PubMed ID: 40082403

Doi: 10.1038/s41467-025-57402-8

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Machine Learning-Aided Identification of Fecal Extracellular Vesicle microRNA Signatures for Noninvasive Detection of Colorectal Cancer

Authors: Zhaowei Zhang, Xuyang Liu, Chuanyue Peng, Rui Du, Xiaoqin Hong, Jia Xu, Jiaming Chen, Xiaomin Li, Yujing Tang, Yuwei Li, Yang Liu, Chen Xu, Dingbin Liu

Journal: ACS Nano

PubMed ID: 40033785

Doi: 10.1021/acsnano.4c16698

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GPR132 regulates the function of NK cells through the Gαs/CSK/ZAP70/NF-κB signaling pathway as a potential immune checkpoint

Authors: Xinhui Hui, Min Xue, Yaojun Ren, Yiran Chen, Xuenan Chen, Muhammad Asad Farooq, Yuzhou Ji, Weirong Zhan, Yunhe Huang, Bingtan Du, Jie Yao, Yixin Duan, Wenzheng Jiang

Journal: Sci Adv

PubMed ID: 40043109

Doi: doi/10.1126/sciadv.adr9395

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Manganese-Driven Plasmid Nanofibers Formed In Situ for Cancer Gene Delivery and Metalloimmunotherapy

Authors: Jiexin Li, Ruiqi Yang, Chen Zhang, Jonathan F Lovell, Yumiao Zhang

Journal: J Am Chem Soc

PubMed ID: 40065259

Doi: 10.1021/jacs.4c18511

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Meiotic crossovers revealed by differential visualization of homologous chromosomes using enhanced haplotype oligo-painting in cucumber

Authors: Yafeng Wu，Zixuan Chen，Fengxiang Chen，Juan Su，Jianyu Han，Songqin Liu

Journal: Plant Biotechnol J

PubMed ID: 39661709

Doi: 10.1111/pbi.14546

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Examining the Role of Threonine Phosphorylation in Ubiquitin’s Function Using Chemical Protein Synthesis

Authors: Bingji Wang, Chuntong Li, Fangyu Zhao, Luyu Shi, Xu Li, Yijie Liu, Shuzhe Sun, Ligong Yuan, Maoshen Sun, Yingyue Zhang, Jing Shi, Lu-Jun Liang

Journal: JACS Au

Doi: doi/10.1021/jacsau.5c00067

Products & Services: Protein Electrophoresis and Western

Mechanisms of NLRP3 activation and inhibition elucidated by functional analysis of disease-associated variants

Authors: Shouya Feng, Matthew C Wierzbowski, Katja Hrovat-Schaale, Andreas Dumortier, Yaoyuan Zhang, Maria Zyulina, Paul J Baker, Thomas Reygaerts, Annemarie Steiner, Dominic De Nardo, Dhanya Lakshmi Narayanan, Florian Milhavet, Alberto Pinzon-Charry, Juan Ignacio Arostegui, Raju P Khubchandani, Matthias Geyer, Guilaine Boursier, Seth L Masters

Journal: nature immunology

PubMed ID: 39930093

Doi: 10.1038/s41590-025-02088-9

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GLP1 alleviates oleic acid-propelled lipocalin-2 generation by tumor-infiltrating CD8+ T cells to reduce polymorphonuclear MDSC recruitment and enhances viral immunotherapy in pancreatic cancer

Authors: Jingyi Wu, Peng Qian, Yifeng Han, Chuning Xu, Mao Xia, Ping Zhan, Jiwu Wei, Jie Dong

Journal: Cellular & molecular immunology

PubMed ID: 39910336

Doi: 10.1038/s41423-025-01260-3

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SUMO4 promotes SUMO deconjugation required for DNA double-strand-break repair

Authors: Alexander J Garvin, Alexander J Lanz, George E Ronson, Matthew J W Mackintosh, Katarzyna Starowicz, Alexandra K Walker, Yara Aghabi, Hannah MacKay, Ruth M Densham, Jai S Bhachoo, Aneika C Leney, Joanna R Morris

Journal: Mol Cell

PubMed ID: 40054443

Doi: 10.1016/j.molcel.2025.02.004

Products & Services: Gene Synthesis Mutagenesis Services PCR Cloning and Subcloning Peptide Synthesis

The OsIAA3-OsARF16-OsBUL1 auxin signaling module regulates grain size in rice

Authors: Fengjun Xian, Shuya Liu, Jishuai Huang, Bin Xie, Lin Zhu, Qiannan Zhang, Chen Lv, Yimeng Xu, Xinrong Zhang, Jun Hu

Journal: Plant Physiol

PubMed ID: 40156155

Doi: 10.1093/plphys/kiaf122

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ER nests are specialized ER subdomains in Arabidopsis where peroxisomes and lipid droplets form

Authors: Zachary J Wright , Nathan E Tharp , Bonnie Bartel

Journal: Developmental Cell

Doi: 10.1016/j.devcel.2025.03.005

Products & Services: Gene Synthesis Protein Electrophoresis and Western

Active- and Allosteric-Site Cyclic Peptide Inhibitors of Secreted M. tuberculosis Chorismate Mutase

Authors: Renier H P van Neer, Patricia K Dranchak, Mahesh Aitha, Lijun Liu, Emma K Carlson, Isabella E Jacobsen, Kevin Battaile, Yuhong Fang, Dingyin Tao, Ganesha Rai, Janak Padia, Scott Lovell, Hiroaki Suga, James Inglese

Journal: ACS Infectious Diseases

PubMed ID: 39903128

Doi: 10.1021/acsinfecdis.4c00798

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Potential role of TRAF2 in pulmonary hypertension in broiler chickens and preparation and specificity analysis of its polyclonal antibody

Authors: Wen Peng, Gen Wan, Sufang Cheng, Guyue Li, Liling Liu, Juan Chen, Pei Liu, Xiaoquan Guo, Xiaona Gao, Gaofeng Cai, Zhanhong Zheng, Ping Liu

Journal: Int J Biol Macromol

PubMed ID: 39798767

Doi: doi.org/10.1016/j.ijbiomac.2025.139741

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FLT1 and other candidate fetal haemoglobin modifying loci in sickle cell disease in African ancestries

Authors: Ambroise Wonkam, Kevin Esoh, Rachel M Levine, Valentina Josiane Ngo Bitoungui, Khuthala Mnika, Nikitha Nimmagadda, Erin A D Dempsey, Siana Nkya, Raphael Z Sangeda, Victoria Nembaware, Jack Morrice, Fujr Osman, Michael A Beer, Julie Makani, Nicola Mulder, Guillaume Lettre, Martin H Steinberg, Rachel Latanich, James F Casella, Daiana Drehmer, Dan E Arking, Emile R Chimusa, Jonathan S Yen, Gregory A Newby, Stylianos E Antonarakis

Journal: Nature Communications

PubMed ID: 40025045

Doi: 10.1038/s41467-025-57413-5

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Simultaneous CRISPR screening and spatial transcriptomics reveal intracellular, intercellular, and functional transcriptional circuits

Authors: Loϊc Binan, Aiping Jiang, Serwah A Danquah, Vera Valakh, Brooke Simonton, Jon Bezney, Robert T Manguso, Kathleen B Yates, Ralda Nehme, Brian Cleary, Samouil L Farhi

Journal: Cell

PubMed ID: 40081369

Doi: 10.1016/j.cell.2025.02.012

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Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity

Authors: Liora S Katz, Emira J Visser, Kathrin F Plitzko, Marloes A M Pennings, Peter J Cossar, Isabelle L Tse, Markus Kaiser, Luc Brunsveld, Christian Ottmann, Donald K Scott

Journal: Nature Communications

PubMed ID: 40025013

Doi: 10.1038/s41467-025-57241-7

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Structures of complete HIV-1 TAR RNA portray a dynamic platform poised for protein binding and structural remodeling

Authors: Charles Bou-Nader, Katie A Link, Krishna C Suddala, Jay R Knutson, Jinwei Zhang

Journal: Nature Communications

PubMed ID: 40050622

Doi: 10.1038/s41467-025-57519-w

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Blockade of ZMIZ1-GATA4 Axis Regulation Restores Youthfulness to Aged Cartilage

Authors: Jiho Nam, Hyunmin Woo, Jihye Yang, Seok Jung Kim, Kwang Pyo Lee, Ji Hoon Yu, Tae Joo Park, Seong-Il Eyun, Siyoung Yang

Journal: Advanced Science

PubMed ID: 40040621

Doi: 10.1002/advs.202404311

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Structural dynamics of DNA unwinding by a replicative helicase

Authors: Taha Shahid, Ammar U Danazumi, Muhammad Tehseen, Lubna Alhudhali, Alice R Clark, Christos G Savva, Samir M Hamdan, Alfredo De Biasio

Journal: Nature

PubMed ID: 40108462

Doi: 10.1038/s41586-025-08766-w

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Plant essential oil targets TRPV3 for skin renewal and structural mechanism of action

Authors: Yang Li, Xuteng Lu, Xufeng Cheng, Keyu Xia, Junyan Hu, Peiyu Wang, Peiyuan Pang, Bomin Gao, Demeng Sun, Zhuzhen Zhang, Dongdong Li, Zengqin Deng, Changlin Tian, Chang Xie, Jing Yao

Journal: Nature Communications

PubMed ID: 40108208

Doi: 10.1038/s41467-025-58033-9

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Structural basis of gap-filling DNA synthesis in the nucleosome by DNA Polymerase β

Authors: Tyler M Weaver, Benjamin J Ryan, Spencer H Thompson, Adil S Hussen, Jonah J Spencer, Zhen Xu, Nicholas J Schnicker, Bret D Freudenthal

Journal: Nature Communications

PubMed ID: 40097433

Doi: 10.1038/s41467-025-57915-2

Products & Services: Codon Optimization

Structural recognition and stabilization of tyrosine hydroxylase by the J-domain protein DNAJC12

Authors: Mary Dayne S Tai, Lissette Ochoa, Marte I Flydal, Lorea Velasco-Carneros, Jimena Muntaner, César Santiago, Gloria Gamiz-Arco, Fernando Moro, Kunwar Jung-Kc, David Gil-Cantero, Miguel Marcilla, Juha P Kallio, Arturo Muga, José María Valpuesta, Jorge Cuéllar, Aurora Martinez

Journal: Nature Communications

PubMed ID: 40113792

Doi: 10.1038/s41467-025-57733-6

Mimicry of molecular glues using dual covalent chimeras

Authors: Eden Kapcan, Karolina Krygier, Maya da Luz, Nickolas J Serniuck, Ali Zhang, Jonathan Bramson, Anthony F Rullo

Journal: Nature Communications

PubMed ID: 40128528

Doi: 10.1038/s41467-025-58083-z

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Conformational reorganization and phase separation drive hyper-editing of ADR-2-ADBP-1 complex

Authors: Jianqiang Mu, Cang Wu, Kaiming Xu, Xingang Liu, Yajuan Fu, Zhen Zhang, Jingwei Yu, Chenyang Xue, Zi Wang, Xinmeng Chen, Yanhong Chen, Guangshuo Ou, Zhongmin Liu

Journal: Nucleic Acids Res

PubMed ID: 40037706

Doi: 10.1093/nar/gkaf148

Resilient Membranized Coacervates Formed through Spontaneous Wrapping of Heat-Destabilized Lipid Bilayers around Coacervate Droplets

Authors: Sadaf Javed, Evan Spruijt

Journal: Advanced Science

PubMed ID: 40116289

Doi: 10.1002/advs.202412312

Bacterial Hachiman complex executes DNA cleavage for antiphage defense

Authors: Yongqing Cui, Zhikang Dai, Yufei Ouyang, Chunyang Fu, Yanjing Wang, Xueting Chen, Kaiyue Yang, Shuyue Zheng, Wenwen Wang, Pan Tao, Zeyuan Guan, Tingting Zou

Journal: Nature Communications

PubMed ID: 40097437

Doi: 10.1038/s41467-025-57851-1

Enhanced SIRT3 expression restores mitochondrial quality control mechanism to reverse osteogenic impairment in type 2 diabetes mellitus

Authors: Yansi Xian, Bin Liu, Tao Shen, Lin Yang, Rui Peng, Hongdou Shen, Xueying An, Yutian Wang, Yu Ben, Qing Jiang, Baosheng Guo

Journal: Bone Res

PubMed ID: 40025004

Doi: 10.1038/s41413-024-00399-5

Products & Services: Protein and Antibody Isolation

Structure-Guided Development of Chemically Tailored Peptide Binders of RNF43/ZNRF3 to Enable Versatile Design of Membrane Protein-Targeting PROTACs

Authors: Jibin Cui , Qingyun Zheng , Yicheng Weng , Xiaoguo Zhai , Zhen Su , Yunxiang Du , Xiaoxiong Wei , Yuanyuan Yu , Qian Qu , Man Pan

Journal: Analytical Chemistry

PubMed ID: 40000409

Doi: doi.org/10.1002/anie.202501488

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Rational Design Assisted by Evolutionary Engineering Allows (De)Construction and Optimization of Complex Phenotypes in Pseudomonas putida KT2440

Authors: Blas Blázquez, Juan Nogales

Journal: Microbial biotechnology

PubMed ID: 40126873

Doi: 10.1111/1751-7915.70132

Products & Services: Gene Synthesis

Enhancing Prime Editing Efficiency Through Modulation of Methylation on the Newly Synthesized DNA Strand and Prolonged Expression

Authors: Xiaosong Han, Xianghua Xu, Youcai Xiong, Guangxing Zhao, Ruigao He, Yinyu Su, Sheng Li, Changzhi Zhao, Xiaoning Xi, Yunxia Zhao, Xuewen Xu, Shengsong Xie, Heng Wang, Xinyun Li, Shuhong Zhao, Jinxue Ruan

Journal: Advanced Science

PubMed ID: 40051369

Doi: 10.1002/advs.202417790

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Epstein-Barr virus infection promotes T cell dysregulation in a humanized mouse model of multiple sclerosis

Authors: Jessica R Allanach, Naomi M Fettig, Blair K Hardman, Ariel R Rosen, Vina Fan, Cynthia Chung, Erin J Goldberg, Zachary J Morse, Iryna Shanina, Galina Vorobeychik, Lisa C Osborne, Marc S Horwitz

Journal: SCIENCE ADVANCES

PubMed ID: 40043135

Doi: 10.1126/sciadv.adu5110

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Immunomodulatory role of the stem cell circadian clock in muscle repair

Authors: Pei Zhu, Eric M Pfrender, Adam W T Steffeck, Colleen R Reczek, Yalu Zhou, Abhishek Vijay Thakkar, Neha R Gupta, Ariana Kupai, Amber Willbanks, Richard L Lieber, Ishan Roy, Navdeep S Chandel, Clara B Peek

Journal: SCIENCE ADVANCES

PubMed ID: 40043110

Doi: 10.1126/sciadv.adq8538

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Integration of multi-omics data accelerates molecular analysis of common wheat traits

Authors: Ning Zhang, Li Tang, Songgang Li, Lu Liu, Mengjuan Gao, Sisheng Wang, Daiying Chen, Yichao Zhao, Ruiqing Zheng, Armin Soleymaniniya, Lingran Zhang, Wenkang Wang, Xia Yang, Yan Ren, Congwei Sun, Mathias Wilhelm, Daowen Wang, Min Li, Feng Chen

Journal: Nature Communications

PubMed ID: 40038279

Doi: 10.1038/s41467-025-57550-x

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Elevated NAD+ drives Sir2A-mediated GCβ deacetylation and OES localization for Plasmodium ookinete gliding and mosquito infection

Authors: Yang Shi, Lin Wan, Mengmeng Jiao, Chuan-Qi Zhong, Huiting Cui, Jing Yuan

Journal: Nature Communications

PubMed ID: 40050296

Doi: 10.1038/s41467-025-57517-y

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A globular protein exhibits rare phase behavior and forms chemically regulated orthogonal condensates in cells

Authors: Jinglei Nie, Xinyi Zhang, Zhijuan Hu, Wei Wang, Martin A Schroer, Jie Ren, Dmitri Svergun, Anyang Chen, Peiguo Yang, An-Ping Zeng

Journal: Nature Communications

PubMed ID: 40069234

Doi: 10.1038/s41467-025-57886-4

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Soft-matter-induced orderings in a solid-state van der Waals heterostructure

Authors: Kai Zhao, Baojuan Dong, Yuang Wang, Xiaoxue Fan, Qi Wang, Zhiren Xiong, Jing Zhang, Jinkun He, Kaining Yang, Minru Qi, Chengbing Qin, Tongyao Zhang, Maolin Chen, Hanwen Wang, Jianqi Huang, Kai Liu, Hanwei Huang, Kenji Watanabe, Takashi Taniguchi, Yaning Wang, Xixiang Zhang, Juehan Yang, Zhenwen Huang, Yongjun Li, Zhongming Wei, Jing Zhang, Shuoxing Jiang, Zheng Vitto Han, Funan Liu

Journal: Nature Communications

PubMed ID: 40064923

Doi: 10.1038/s41467-025-57690-0

Structural basis for the allosteric activation of Lon by the heat shock protein LarA

Authors: Hsiu-Jung Wang, Yun-Erh Kuan, Meng-Ru Ho, Chung-I Chang

Journal: Nature Communications

PubMed ID: 40044692

Doi: 10.1038/s41467-025-57482-6

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Selective promotion of sensory innervation-mediated immunoregulation for tissue repair

Authors: Kaicheng Xu, Kaile Wu, Liang Chen, Yubin Zhao, Hengyuan Li, Nong Lin, Zhaoming Ye, Jianbin Xu, Donghua Huang, Xin Huang

Journal: SCIENCE ADVANCES

PubMed ID: 40117376

Doi: 10.1126/sciadv.ads9581

Functional and antigenic landscape of the Nipah virus receptor-binding protein

Authors: Brendan B Larsen, Teagan McMahon, Jack T Brown, Zhaoqian Wang, Caelan E Radford, James E Crowe Jr, David Veesler, Jesse D Bloom

Journal: Cell

PubMed ID: 38659959

Doi: 10.1101/2024.04.17.589977

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Cryo-EM Analysis of a Tri-Heme Cytochrome-Associated RC-LH1 Complex from the Marine Photoheterotrophic Bacterium Dinoroseobacter Shibae

Authors: Weiwei Wang, Yanting Liu, Jiayi Gu, Shaoya An, Cheng Ma, Haichun Gao, Nianzhi Jiao, Jian-Ren Shen, John Thomas Beatty, Michal Koblížek, Xing Zhang, Qiang Zheng, Jing-Hua Chen

Journal: Advanced Science

PubMed ID: 40112203

Doi: 10.1002/advs.202413456

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Overlapping and separable activities of BRA-2 and HIM-17 promote occurrence and regulation of pairing and synapsis during Caenorhabditis elegans meiosis

Authors: Jitka Blazickova, Shalini Trivedi, Richard Bowman, Sowmya Sivakumar Geetha, Silma Subah, Michelle Scuzzarella, Alexander Chang, Uma R Chandran, Judith L Yanowitz, Sarit Smolikove, Verena Jantsch, Monique Zetka, Nicola Silva

Journal: Nature Communications

PubMed ID: 40082424

Doi: 10.1038/s41467-025-57862-y

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Oral delivery of therapeutic proteins by engineered bacterial type zero secretion system

Authors: Xu Gong , Shan Liu , Bozhang Xia , Yichen Wan , Shuyi Zhang , Baoyan Zhang , Zehao Wang , Junge Chen , Fei Xiao , Xing-Jie Liang , Yun Yang

Journal: Nat Commun

PubMed ID: 39984501

Doi: 10.1038/s41467-025-57153-6

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EXPERT expands prime editing efficiency and range of large fragment edits

Authors: Youcai Xiong , Yinyu Su , Ruigao He , Xiaosong Han , Sheng Li , Minghuan Liu , Xiaoning Xi , Zijia Liu , Heng Wang , Shengsong Xie , Xuewen Xu , Kui Li , Jifeng Zhang , Jie Xu , Xinyun Li , Shuhong Zhao , Jinxue Ruan

Journal: Nat Commun

PubMed ID: 39939583

Doi: 10.1038/s41467-025-56734-9

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Self-assembly GSH response based Buforin IIb-Olaparib nanocombination synergistically promotes DNA damage for prostate cancer immunotherapy

Authors: Maosong Hu , Yuyu Zhu , Xinyi Tang , Jing Xu , Hanbin Ma , Zhihan Chen , Duo Chen , Wenyuan Wu , Xialin Chen , Rongrong He , Jing Zhou , Jinao Duan , Weiguo Chen , Hongyue Ma

Journal: Chemical Engineering Journal

Doi: 10.1016/j.cej.2025.160862

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Deciphering molecular specificity in MCL-1/BAK interaction and its implications for designing potent MCL-1 inhibitors

Authors: Hudie Wei, Haolan Wang, Shuang Xiang, Jiaqi Wang, Lingzhi Qu, Xiaojuan Chen, Ming Guo, Xiaoyun Lu, Yongheng Chen

Journal: Cell Death Differ

PubMed ID: 39901037

Doi: 10.1038/s41418-025-01454-2

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Expanding Cas12a Activity Control with an RNA G-Quadruplex at the 5′ end of CRISPR RNA

Authors: Wenjuan Huang, Jiaqi Wang, Cheng Wang, Yuanfang Liu, Wentao Li, Qiaozhen Chen, Junqiu Zhai, Zhenyang Xiang, Chaoxing Liu

Journal: Advanced Science

PubMed ID: 39721016

Doi: 10.1002/advs.202411305

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