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Hydroxysafflor yellow A inhibits the proliferation, migration, and invasion of colorectal cancer cells through the PPARγ/PTEN/Akt signaling pathway

Authors: Dan Su, Chunye Lv

Journal: Bioengineered

PubMed ID: 34889713

Doi: 10.1080/21655979.2021.2009965

Products & Services: Gene Synthesis

Molecular characterization of equine thymidine kinase 1 and preliminary evaluation of its suitability as a serum biomarker for equine lymphoma

Authors: Liya Wang, Lucia Unger, Hanan Sharif, Staffan Eriksson, Vinzenz Gerber, Henrik Rönnberg

Journal: BMC Mol Cell Biol

PubMed ID: 34906077

Doi: 10.1186/s12860-021-00399-x

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Molecular characterization of equine thymidine kinase 1 and preliminary evaluation of its suitability as a serum biomarker for equine lymphoma

Authors: Liya Wang, Lucia Unger, Hanan Sharif, Staffan Eriksson, Vinzenz Gerber, Henrik Rönnberg

Journal: BMC Mol Cell Biol

PubMed ID: 34906077

Doi: 10.1186/s12860-021-00399-x

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A periplasmic cupredoxin with a green CuT15 center is involved in bacterial copper tolerance

Authors: Anne Durand, Mélanie Fouesnard, Marie-Line Bourbon, Anne-Soisig Steunou, Elisabeth Lojou, Pierre Dorlet, Soufian Ouchane

Journal: Metallomics

PubMed ID: 34791351

Doi: 10.1093/mtomcs/mfab067

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miR‑30a‑5p induces the adipogenic differentiation of bone marrow mesenchymal stem cells by targeting FAM13A/Wnt/β‑catenin signaling in aplastic anemia

Authors: Enbo Wang, Yunyan Zhang, Rongmei Ding, Xiaohua Wang, Shumin Zhang, Xinghua Li

Journal: Mol Med Rep

PubMed ID: 34821370

Doi: 10.3892/mmr.2021.12543

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Incomplete radiofrequency ablation induced chemoresistance by up-regulating heat shock protein 70 in hepatocellular carcinoma

Authors: Fuan Wang, Chuan Xu, Guiling Li, Penghua Lv, Jianping Gu

Journal: Exp Cell Res

PubMed ID: 34801560

Doi: 10.1016/j.yexcr.2021.112910

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Crystal structure of Aedes aegypti trypsin inhibitor in complex with μ-plasmin reveals role for scaffold stability in Kazal-type serine protease inhibitor

Authors: Varsha Ashok Walvekar, Karthik Ramesh, Chacko Jobichen, Muthu Kannan, J Sivaraman, R Manjunatha Kini, Yu Keung Mok

Journal: Protein Sci

PubMed ID: 34800067

Doi: 10.1002/pro.4245

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Relative Ratios of Human Seasonal Coronavirus Antibodies Predict the Efficiency of Cross-Neutralization of SARS-CoV-2 Spike Binding to ACE2

Authors: Yannick Galipeau, Vinayakumar Siragam, Geneviève Laroche, Erika Marion, Matthew Greig, Michaeline McGuinty, Ronald A Booth, Yves Durocher, Miroslava Cuperlovic-Culf, Steffany A L Bennett, Angela M Crawley, Patrick M Giguère, Curtis Cooper, Marc-André Langlois

Journal: EBioMedicine

PubMed ID: 34861490

Doi: 10.1016/j.ebiom.2021.103700

Products & Services: Codon Optimization

The Marine Neurotoxin Brevetoxin (PbTx-2) Inhibits and Mammalian Thioredoxin Reductases by Targeting Different Residues

Authors: Ricardo Colon, Michelle Wheater, Emily J Joyce, Emma J Ste Marie, Robert J Hondal, Kathleen S Rein

Journal: J Nat Prod

PubMed ID: 34752085

Doi: 10.1021/acs.jnatprod.1c00795

Products & Services: Codon Optimization

Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs

Authors: Sophie M-C Gobeil, Benjamin G Bobay, Praveen R Juvvadi, D Christopher Cole, Joseph Heitman, William J Steinbach, Ronald A Venters, Leonard D Spicer

Journal: MBio

PubMed ID: 34809463

Doi: 10.1128/mBio.03000-21

Products & Services: Codon Optimization

Multilayered regulation of autophagy by the Atg1 kinase orchestrates spatial and temporal control of autophagosome formation

Authors: Anne Schreiber, Ben C Collins, Colin Davis, Radoslav I Enchev, Angie Sedra, Rocco D'Antuono, Ruedi Aebersold, Matthias Peter

Journal: Mol Cell

PubMed ID: 34798055

Doi: 10.1016/j.molcel.2021.10.024

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Hydrophobicity-tuned anion responsiveness underlies endosomolytic cargo delivery mediated by amphipathic vehicle peptides

Authors: Xiaolong Chen, Hanjie Liu, Ang Li, Shuangshuang Ji, Hao Fei

Journal: J Biol Chem

PubMed ID: 34736897

Doi: 10.1016/j.jbc.2021.101364

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Heterotypic Amyloid β interactions facilitate amyloid assembly and modify amyloid structure

Authors: Katerina Konstantoulea, Patricia Guerreiro, Meine Ramakers, Nikolaos Louros, Liam D Aubrey, Bert Houben, Emiel Michiels, Matthias De Vleeschouwer, Yulia Lampi, Luís F Ribeiro, Joris de Wit, Wei-Feng Xue, Joost Schymkowitz, Frederic Rousseau

Journal: EMBO J

PubMed ID: 34842295

Doi: 10.15252/embj.2021108591

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TG2-gluten complexes as antigens for gluten-specific and transglutaminase-2 specific B cells in celiac disease

Authors: Christian B Lindstad, Alisa E Dewan, Jorunn Stamnaes, Ludvig M Sollid, M Fleur du Pré

Journal: PLoS ONE

PubMed ID: 34731200

Doi: 10.1371/journal.pone.0259082

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T-cell and antibody responses to first BNT162b2 vaccine dose in previously infected and SARS-CoV-2-naive UK health-care workers: a multicentre prospective cohort study

Authors: Adrienn Angyal, Stephanie Longet, Shona C Moore, Rebecca P Payne, Adam Harding, Tom Tipton, Patpong Rongkard, Mohammad Ali, Luisa M Hering, Naomi Meardon, James Austin, Rebecca Brown, Donal Skelly, Natalie Gillson, Sue L Dobson, Andrew Cross, Gurjinder Sandhar, Jonathan A Kilby, Jessica K Tyerman, Alexander R Nicols, Jarmila S Spegarova, Hema Mehta, Hailey Hornsby, Rachel Whitham, Christopher P Conlon, Katie Jeffery, Philip Goulder, John Frater, Christina Dold, Matthew Pace, Ane Ogbe, Helen Brown, M Azim Ansari, Emily Adland, Anthony Brown, Meera Chand, Adrian Shields, Philippa C Matthews, Susan Hopkins, Victoria Hall, William James, Sarah L Rowland-Jones, Paul Klenerman, Susanna Dunachie, Alex Richter, Christopher J A Duncan, Eleanor Barnes, Miles Carroll, Lance Turtle, Thushan I de Silva

Journal: Lancet Microbe

PubMed ID: 34778853

Doi: 10.1016/S2666-5247(21)00275-5

Products & Services: Catalog Peptides

Identification of immunogenic MHC class II human HER3 peptides that mediate anti-HER3 CD4+ Th1 responses and potential use as a cancer vaccine

Authors: Amrita Basu, Gabriella K Albert, Sabrina Awshah, Jashodeep Datta, Krithika N Kodumudi, Corey Gallen, Amber Beyer, Keiran S M Smalley, Paulo C Rodriguez, Derek R Dukett, Peter A Forsyth, Aixa Soyano, Gary K Koski, Ricardo Lima Barros Costa, Heather Han, Hatem Soliman, Marie Catherine Lee, Pawel Kalinski, Brian J Czerniecki

Journal: Cancer Immunol Res

PubMed ID: 34785506

Doi: 10.1158/2326-6066.CIR-21-0454

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Peptide-coating 2D and small chemical molecules prolong the passage of porcine spermatogonia stem cells

Authors: Ying Zhang, Camila Bruna de Lima, Zhe Zhou, Qiaoyan Shen, Zhenshuo Zhu, Jinlian Hua

Journal: Reprod Domest Anim

PubMed ID: 34748668

Doi: 10.1111/rda.14042

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Suppression of a Novel Vitellogenesis-Inhibiting Hormone Significantly Increases Ovarian Vitellogenesis in the Black Tiger Shrimp,

Authors: Phaivit Laphyai, Thanapong Kruangkum, Charoonroj Chotwiwatthanakun, Wanita Semchuchot, Prawporn Thaijongrak, Prasert Sobhon, Pei-San Tsai, Rapeepun Vanichviriyakit

Journal: Front Endocrinol (Lausanne)

PubMed ID: 34867802

Doi: 10.3389/fendo.2021.760538

Products & Services: Gene Synthesis

Neoantigen Dendritic Cell Vaccination Combined with Anti-CD38 and CpG Elicits Anti-Tumor Immunity against the Immune Checkpoint Therapy-Resistant Murine Lung Cancer Cell Line LLC1

Authors: Changbo Sun, Koji Nagaoka, Yukari Kobayashi, Hidewaki Nakagawa, Kazuhiro Kakimi, Jun Nakajima

Journal: Cancers (Basel)

PubMed ID: 34771674

Doi: 10.3390/cancers13215508

Products & Services: Custom DNA/RNA Oligos

Engineering of for 24-Methylene-Cholesterol Production

Authors: Jiao Yang, Changfu Li, Yansheng Zhang

Journal: Biomolecules

PubMed ID: 34827708

Doi: 10.3390/biom11111710

Products & Services: Gene Synthesis

High-Throughput On-Chip Human Mesenchymal Stromal Cell Potency Prediction

Authors: Rebecca S Schneider, Alexandra C Vela, Evelyn Kendall Williams, Karen E Martin, Wilbur A Lam, Andrés J García

Journal: Adv Healthc Mater

PubMed ID: 34725948

Doi: 10.1002/adhm.202101995

Products & Services: Peptide Synthesis

The flagellin of Vibrio parahaemolyticus induces the inflammatory response of Tetraodon nigroviridis through TLR5M

Authors: Xue Yu, Songze Gao, Jiachang Xu, Yulin Zhao, Yuyou Lu, Niuniu Deng, Haoran Lin, Yong Zhang, Danqi Lu

Journal: Fish Shellfish Immunol

PubMed ID: 34737057

Doi: 10.1016/j.fsi.2021.10.024

Products & Services: Proteins, Expression, Isolation and Analysis

HO Functions as a Downstream Signal of IAA to Mediate HS-Induced Chilling Tolerance in Cucumber

Authors: Xiaowei Zhang, Yanyan Zhang, Chenxiao Xu, Kun Liu, Huangai Bi, Xizhen Ai

Journal: Int J Mol Sci

PubMed ID: 34884713

Doi: 10.3390/ijms222312910

Products & Services: Gene Synthesis

sp nov, isolated from Arctic tundra soil, and emended descriptions of , and

Authors: Yongping Zhang, Xiaoya Peng, Kun Qin, Jia Liu, Qiang Xu, Jingjing Niu, Yanyan Zheng, Fang Peng

Journal: Int J Syst Evol Microbiol

PubMed ID: 34846279

Doi: 10.1099/ijsem.0.005103

Products & Services: Gene Synthesis

Pharmacokinetic Assessment of Rottlerin from Using a Highly Sensitive Liquid Chromatography-Tandem Mass Spectrometry-Based Bioanalytical Method

Authors: Diksha Manhas, Abhishek Gour, Nivedita Bhardwaj, Deepak K Sharma, Kuhu Sharma, Bhavna Vij, Shreyans K Jain, Gurdarshan Singh, Utpal Nandi

Journal: ACS Omega

PubMed ID: 34901612

Doi: 10.1021/acsomega.1c04266

Products & Services: Gene Synthesis

Geminin is essential for DNA re-replication in the silk gland cells of silkworms

Authors: Tai-Hang Liu, Xiao-Long Dong, Peng Chen, Qian Zhang, Xiao-Lin Zhou, Cheng Lu, Min-Hui Pan

Journal: Exp Cell Res

PubMed ID: 34843715

Doi: 10.1016/j.yexcr.2021.112951

Products & Services: Gene Synthesis

Toxicological Evaluation of a Probiotic-Based Delivery System for P8 Protein as an Anti-Colorectal Cancer Drug

Authors: Byung Chull An, Yeo-Sang Yoon, Ho Jin Park, Sangkyun Park, Tai Yeub Kim, Jun Young Ahn, Daebeom Kwon, Oksik Choi, Jin Young Heo, Yongku Ryu, Joong-Hyun Kim, Heejong Eom, Myung Jun Chung

Journal: Drug Des Devel Ther

PubMed ID: 34866901

Doi: 10.2147/DDDT.S319930

Products & Services: Gene Synthesis

Preparation of multiplexed control materials for cancer mutation analysis by genome editing in GM12878 cells

Authors: Guigao Lin, Kuo Zhang, Yanxi Han, Rongxue Peng, Jinming Li

Journal: J Clin Lab Anal

PubMed ID: 34811797

Doi: 10.1002/jcla.24139

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Cul4A-DDB1-mediated monoubiquitination of phosphoglycerate dehydrogenase promotes colorectal cancer metastasis via increased S-adenosylmethionine

Authors: Yajuan Zhang, Hua Yu, Jie Zhang, Hong Gao, Siyao Wang, Shuxian Li, Ping Wei, Ji Liang, Guanzhen Yu, Xiongjun Wang, Xinxiang Li, Dawei Li, Weiwei Yang

Journal: J Clin Invest

PubMed ID: 34720086

Doi: 10.1172/JCI146187

Products & Services: Proteins, Expression, Isolation and Analysis

ORAI1 Limits SARS-CoV-2 Infection by Regulating Tonic Type I IFN Signaling

Authors: Beibei Wu, Arunachalam Ramaiah, Gustavo Garcia, Spyridon Hasiakos, Vaithilingaraja Arumugaswami, Sonal Srikanth

Journal: J Immunol

PubMed ID: 34819389

Doi: 10.4049/jimmunol.2100742

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Trichinella spiralis: Knockdown of gamma interferon inducible lysosomal thiol reductase (GILT) results in the reduction of worm burden

Authors: Hong Fei, Muhammad Ali-Ul-Husnain Naqvi, Sana Zahra Naqvi, Lixin Xu, Xiaokai Song, Xiangrui Li, Ruofeng Yan

Journal: PLoS Negl Trop Dis

PubMed ID: 34847145

Doi: 10.1371/journal.pntd.0009958

Products & Services: Proteins, Expression, Isolation and Analysis

Key carboxylate residues for iron transit through the prokaryotic ferritin Ftn

Authors: Justin M Bradley, Joshua Fair, Andrew M Hemmings, Nick E Le Brun

Journal: Microbiology (Reading)

PubMed ID: 34825885

Doi: 10.1099/mic.0.001105

Products & Services: Bacterial Expression

Development of a novel promoter engineering-based strategy for creating an efficient para-nitrophenol-mineralizing bacterium

Authors: Kaiyue Huo, Yujie Liu, Rui Huang, Yiting Zhang, Honglu Liu, You Che, Chao Yang

Journal: J Hazard Mater.

PubMed ID: 34753648

Doi: 10.1016/j.jhazmat.2021.127672.

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Neutralization of SARS-CoV-2 Variants in Transplant Recipients After Two and Three Doses of mRNA-1273 Vaccine : Secondary Analysis of a Randomized Trial

Authors: Deepali Kumar, Victor H Ferreira, Victoria G Hall, Queenie Hu, Reuben Samson, Terrance Ku, Matthew Ierullo, Beata Majchrzak-Kita, George Tomlinson, Anne-Claude Gingras, Atul Humar

Journal: Ann Intern Med

PubMed ID: 34807716

Doi: 10.7326/M21-3480

Products & Services: Recombinant Antibody Expression

Author Correction: Disulfide-compatible phage-assisted continuous evolution in the periplasmic space

Authors: Mary S Morrison, Tina Wang, Aditya Raguram, Colin Hemez, David R Liu

Journal: Nat Commun

PubMed ID: 34789771

Doi: 10.1038/s41467-021-27102-0

Products & Services: Recombinant Antibody Expression

The Flawed Science of Antibody Testing for SARS-CoV-2 Immunity

Authors:

Journal: JAMA

PubMed ID: 34673883

Doi: 10.1001/jama.2021.18919

Products & Services: Proteins, Expression, Isolation and Analysis

Bunyavirus SFTSV exploits autophagic flux for viral assembly and egress

Authors: Jia-Min Yan, Wen-Kang Zhang, Li-Na Yan, Yong-Jun Jiao, Chuan-Min Zhou, Xue-Jie Yu

Journal: Autophagy

PubMed ID: 34747299

Doi: 10.1080/15548627.2021.1994296

Products & Services: Proteins, Expression, Isolation and Analysis

Porcine Epidemic Diarrhea Virus Envelope Protein Blocks SLA-DR Expression in Barrow-Derived Dendritic Cells by Inhibiting Promoters Activation

Authors: Jie Wang, Yajing Wang, Bing Liu, Yunwei He, Zhiwei Li, Qin Zhao, Yuchen Nan, Chunyan Wu

Journal: Front Immunol

PubMed ID: 34858400

Doi: 10.3389/fimmu.2021.741425

Products & Services: Proteins, Expression, Isolation and Analysis

Structures of the HER2-HER3-NRG1β complex reveal a dynamic dimer interface

Authors: Devan Diwanji, Raphael Trenker, Tarjani M Thaker, Feng Wang, David A Agard, Kliment A Verba, Natalia Jura

Journal: Nature

PubMed ID: 34759323

Doi: 10.1038/s41586-021-04084-z

Products & Services: Proteins, Expression, Isolation and Analysis

Aggregation and the Intrinsic Structural Disorder of Dipeptide Repeat Peptides of C9orf72-Related Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Characterized by NMR

Authors: Bankala Krishnarjuna, Magdalena I Ivanova, Ayyalusamy Ramamoorthy

Journal: J Phys Chem B

PubMed ID: 34751579

Doi: 10.1021/acs.jpcb.1c08149

Products & Services: Proteins, Expression, Isolation and Analysis

Probing Insulin Sensitivity with Metabolically Competent Human Stem Cell-Derived White Adipose Tissue Microphysiological Systems

Authors: Lin Qi, Peter-James H Zushin, Ching-Fang Chang, Yue Tung Lee, Diana L Alba, Suneil K Koliwad, Andreas Stahl

Journal: Small

PubMed ID: 34761526

Doi: 10.1002/smll.202103157

Products & Services: Proteins, Expression, Isolation and Analysis

YAP Promotes Cell Proliferation and Stemness Maintenance of Porcine Muscle Stem Cells under High-Density Condition

Authors: Zheng Liu, Ling Lin, Haozhe Zhu, Zhongyuan Wu, Xi Ding, Rongrong Hu, Yichen Jiang, Changbo Tang, Shijie Ding, Renpeng Guo

Journal: Cells

PubMed ID: 34831292

Doi: 10.3390/cells10113069

Products & Services: Proteins, Expression, Isolation and Analysis

Chromium induced neurotoxicity by altering metabolism in zebrafish larvae

Authors: Yawen Xu, Li Wang, Jun Zhu, Ping Jiang, Zhan Zhang, Lei Li, Qian Wu

Journal: Ecotoxicol Environ Saf

PubMed ID: 34781135

Doi: 10.1016/j.ecoenv.2021.112983

Products & Services: Proteins, Expression, Isolation and Analysis

A venom protein of ectoparasitoid Pachycrepoideus vindemiae, PvG6PDH, contributes to parasitism by inhibiting host glucose-6-phosphate metabolism

Authors: Lei Yang, Liming Qiu, Qi Fang, Shaoying Wu, Gongyin Ye

Journal: Insect Sci

PubMed ID: 34724344

Doi: 10.1111/1744-7917.12935

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Development of a Self-Adjuvanting, Cross-Protective, Stable Intranasal Recombinant Vaccine for Shigellosis

Authors: Namrata Baruah, Nadim Ahamad, Suhrid Maiti, Debaki R Howlader, Ushasi Bhaumik, Vinod V Patil, Manoj K Chakrabarti, Hemanta Koley, Dhirendra S Katti

Journal: ACS Infect Dis

PubMed ID: 34734708

Doi: 10.1021/acsinfecdis.1c00345

Products & Services: Plasmid DNA Preparation

Improved production of the non-native cofactor F in Escherichia coli

Authors: Mihir V Shah, Hadi Nazem-Bokaee, James Antoney, Suk Woo Kang, Colin J Jackson, Colin Scott

Journal: Sci Rep

PubMed ID: 34741069

Doi: 10.1038/s41598-021-01224-3

Products & Services: Plasmid DNA Preparation

A Histoplasma capsulatum Lipid Metabolic Map Identifies Antifungal Targets

Authors: Daniel Zamith-Miranda, Heino M Heyman, Meagan C Burnet, Sneha P Couvillion, Xueyun Zheng, Nathalie Munoz, William C Nelson, Jennifer E Kyle, Erika M Zink, Karl K Weitz, Kent J Bloodsworth, Geremy Clair, Jeremy D Zucker, Jeremy R Teuton, Samuel H Payne, Young-Mo Kim, Morayma Reyes Gil, Erin S Baker, Erin L Bredeweg, Joshua D Nosanchuk, Ernesto S Nakayasu

Journal: MBio

PubMed ID: 34809453

Doi: 10.1128/mBio.02972-21

Products & Services: Plasmid DNA Preparation

Evaluation of recombinase-based isothermal amplification assays for point-of-need detection of SARS-CoV-2 in resource-limited settings

Authors: Prakash Ghosh, Rajashree Chowdhury, Mohammad Enayet Hossain, Faria Hossain, Mojnu Miah, Md Utba Rashid, James Baker, Mohammed Ziaur Rahman, Mustafizur Rahman, Xuejun Ma, Malcolm S Duthie, Ahmed Abd El Wahed, Dinesh Mondal

Journal: Int J Infect Dis

PubMed ID: 34758392

Doi: 10.1016/j.ijid.2021.11.007

Products & Services: Plasmid DNA Preparation

Mutation Y453F in the spike protein of SARS-CoV-2 enhances interaction with the mink ACE2 receptor for host adaption

Authors: Wenlin Ren, Jun Lan, Xiaohui Ju, Mingli Gong, Quanxin Long, Zihui Zhu, Yanying Yu, Jianping Wu, Jin Zhong, Rong Zhang, Shilong Fan, Guocai Zhong, Ailong Huang, Xinquan Wang, Qiang Ding

Journal: PLoS Pathog

PubMed ID: 34748603

Doi: 10.1371/journal.ppat.1010053

Products & Services: Mutant Libraries

ABAT targeted by miR-183-5p regulates cell functions in liver cancer

Authors: Hui Han, Shenkang Zhou, Gengzhen Chen, Yandi Lu, Hui Lin

Journal: Int J Biochem Cell Biol

PubMed ID: 34742920

Doi: 10.1016/j.biocel.2021.106116

Products & Services: Mutant Libraries

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