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Microbial synthesis of 4-hydroxybenzoic acid from renewable feedstocks

Authors: Yueyang Chen, Yufen Chen, Lijun Liu, Yang Zhang, Jifeng Yuan

Journal: Food Chem (Oxf)

PubMed ID: 35415641

Doi: 10.1016/j.fochms.2021.100059

Products & Services: Gene Synthesis

Peptides GWN and GW protect kidney cells against Dasatinib induced mitochondrial injury in a SIRT1 dependent manner

Authors: Khushwant S Bhullar, Fatemeh Ashkar, Jianping Wu

Journal: Food Chem (Oxf)

PubMed ID: 35415678

Doi: 10.1016/j.fochms.2021.100069

Products & Services: Peptide Synthesis

Synergistic T cell signaling by 41BB and CD28 is optimally achieved by membrane proximal positioning within parallel chimeric antigen receptors

Authors: Tamara Muliaditan, Leena Halim, Lynsey M Whilding, Benjamin Draper, Daniela Y Achkova, Fahima Kausar, Maya Glover, Natasha Bechman, Appitha Arulappu, Jenifer Sanchez, Katie R Flaherty, Jana Obajdin, Kristiana Grigoriadis, Pierre Antoine, Daniel Larcombe-Young, Caroline M Hull, Richard Buus, Peter Gordon, Anita Grigoriadis, David M Davies, Anna Schurich, John Maher

Journal: Cell Rep Med

PubMed ID: 35028604

Doi: 10.1016/j.xcrm.2021.100457

Products & Services: Gene Synthesis

Engineering a Pseudo-26-kDa Glutathione Transferase from / for Structure, Kinetics, and Ligandin Studies

Authors: Neo Padi, Blessing Oluebube Akumadu, Olga Faerch, Chinyere Aloke, Vanessa Meyer, Ikechukwu Achilonu

Journal: Biomolecules

PubMed ID: 34944488

Doi: 10.3390/biom11121844

Products & Services: PCR Cloning and Subcloning

SARS-CoV-2 N Protein Induces Acute Lung Injury in Mice NF-ĸB Activation

Authors: Jie Xia, Wenqi Tang, Jiangmei Wang, Dengming Lai, Qi Xu, Ruoqiong Huang, Yaoqin Hu, Xiaojue Gong, Jiajie Fan, Qiang Shu, Jianguo Xu

Journal: Front Immunol

PubMed ID: 34950152

Doi: 10.3389/fimmu.2021.791753

Products & Services: Proteins, Expression, Isolation and Analysis

SARS-CoV-2 seroprevalence, seroconversion and neutralizing antibodies in a systemic lupus erythematosus cohort and comparison to controls

Authors: Hannah R Mathew, May Y Choi, Katherine Buhler, Xenia Gukova, Francesca S Cardwell, Heather Waldhauser, Ann E Clarke, Marvin J Fritzler

Journal: Lupus

PubMed ID: 34874781

Doi: 10.1177/09612033211063793

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Soybean miR159 Regulatory Network Involved in Gibberellin-Modulated Resistance to

Authors: Piao Lei, Nawei Qi, Yuan Zhou, Yuanyuan Wang, Xiaofeng Zhu, Yuanhu Xuan, Xiaoyu Liu, Haiyan Fan, Lijie Chen, Yuxi Duan

Journal: Int J Mol Sci

PubMed ID: 34884977

Doi: 10.3390/ijms222313172

Products & Services: Proteins, Expression, Isolation and Analysis

Expression profile of RNA binding protein in cervical cancer using bioinformatics approach

Authors: Zhiyuan Huang, Fang Li, Qinchuan Li

Journal: Cancer Cell Int

PubMed ID: 34863153

Doi: 10.1186/s12935-021-02319-7

Products & Services: Custom DNA/RNA Oligos

Non-β-blocker enantiomers of propranolol and atenolol inhibit vasculogenesis in infantile hemangioma

Authors: Caroline T Seebauer, Matthew S Graus, Lan Huang, Alex J McCann, Jill Wylie-Sears, Frank R Fontaine, Tara Karnezis, David Zurakowski, Steven J Staffa, Frédéric A Meunier, John B Mulliken, Joyce Bischoff, Mathias Francois

Journal: J Clin Invest

PubMed ID: 34874911

Doi: 10.1172/JCI151109

Products & Services: ORF cDNA Clones/MolecularCloud

RNF219 attenuates global mRNA decay through inhibition of CCR4-NOT complex-mediated deadenylation

Authors: Fabian Poetz, Joshua Corbo, Yevgen Levdansky, Alexander Spiegelhalter, Doris Lindner, Vera Magg, Svetlana Lebedeva, Jörg Schweiggert, Johanna Schott, Eugene Valkov, Georg Stoecklin

Journal: Nat Commun

PubMed ID: 34887419

Doi: 10.1038/s41467-021-27471-6

Products & Services: GenParts™ DNA Fragments

HTLV-1 infection promotes excessive T cell activation and transformation into adult T cell leukemia/lymphoma

Authors: Benjy Jy Tan, Kenji Sugata, Omnia Reda, Misaki Matsuo, Kyosuke Uchiyama, Paola Miyazato, Vincent Hahaut, Makoto Yamagishi, Kaoru Uchimaru, Yutaka Suzuki, Takamasa Ueno, Hitoshi Suzushima, Hiroo Katsuya, Masahito Tokunaga, Yoshikazu Uchiyama, Hideaki Nakamura, Eisaburo Sueoka, Atae Utsunomiya, Masahiro Ono, Yorifumi Satou

Journal: J Clin Invest

PubMed ID: 34907908

Doi: 10.1172/JCI150472

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Nonspecific binding of common anti-CFTR antibodies in ciliated cells of human airway epithelium

Authors: Yukiko Sato, Kamila R Mustafina, Yishan Luo, Carolina Martini, David Y Thomas, Paul W Wiseman, John W Hanrahan

Journal: Sci Rep

PubMed ID: 34853321

Doi: 10.1038/s41598-021-02420-x

Products & Services: Plasmid DNA Preparation

GPR180 is a component of TGFβ signalling that promotes thermogenic adipocyte function and mediates the metabolic effects of the adipocyte-secreted factor CTHRC1

Authors: Lucia Balazova, Miroslav Balaz, Carla Horvath, Áron Horváth, Caroline Moser, Zuzana Kovanicova, Adhideb Ghosh, Umesh Ghoshdastider, Vissarion Efthymiou, Elke Kiehlmann, Wenfei Sun, Hua Dong, Lianggong Ding, Ez-Zoubir Amri, Pirjo Nuutila, Kirsi A Virtanen, Tarja Niemi, Barbara Ukropcova, Jozef Ukropec, Pawel Pelczar, Thorsten Lamla, Bradford Hamilton, Heike Neubauer, Christian Wolfrum

Journal: Nat Commun

PubMed ID: 34880217

Doi: 10.1038/s41467-021-27442-x

Products & Services: Mammalian Expression

Rice stripe virus activates the bZIP17/28 branch of the unfolded protein response signalling pathway to promote viral infection

Authors: Chenyang Li, Tianze Zhang, Yu Liu, Zongdi Li, Yaqin Wang, Shuai Fu, Yi Xu, Tong Zhou, Jianxiang Wu, Xueping Zhou

Journal: Mol Plant Pathol

PubMed ID: 34897936

Doi: 10.1111/mpp.13171

Products & Services: Catalog Antibody

Construction, expression, purification, characterization, and structural analysis of microbial transglutaminase variants

Authors: Xiaoping Song, Hefang Sheng, Yueqiao Zhou, Yin Yu, Yingjiao He, Zihan Wang

Journal: Biotechnol Appl Biochem

PubMed ID: 34894362

Doi: 10.1002/bab.2298

Products & Services: Recombinant Antibody Expression

Edaravone Improves the Post-traumatic Brain Injury Dysfunction in Learning and Memory by Modulating Nrf2/ARE Signal Pathway

Authors: Xiushan Li, Jing Yu, Dongzhou Ma, Xuehui Weng

Journal: Clinics (Sao Paulo)

PubMed ID: 34878029

Doi: 10.6061/clinics/2021/e3131

Products & Services: Plasmid DNA Preparation

Tanshinone IIA sodium sulfonate attenuates inflammation by upregulating circ-Sirt1 and inhibiting the entry of NF-κB into the nucleus

Authors: Jiao Lan, Ke Li, Austin Gresham, Jifei Miao

Journal: Eur J Pharmacol

PubMed ID: 34896110

Doi: 10.1016/j.ejphar.2021.174693

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Seven-Month Analysis of Five SARS-CoV-2 Antibody Assay Results after ChAdOx1 nCoV-19 Vaccination: Significant Decrease in SARS-CoV-2 Antibody Titer

Authors: Seri Jeong, Nuri Lee, Su-Kyung Lee, Eun-Jung Cho, Jungwon Hyun, Min-Jeong Park, Wonkeun Song, Eun-Ju Jung, Heungjeong Woo, Yu-Bin Seo, Jin-Ju Park, Hyun-Soo Kim

Journal: Diagnostics (Basel)

PubMed ID: 35054251

Doi: 10.3390/diagnostics12010085

Products & Services: Catalog Antibody

Seven-Month Analysis of Five SARS-CoV-2 Antibody Assay Results after ChAdOx1 nCoV-19 Vaccination: Significant Decrease in SARS-CoV-2 Antibody Titer

Authors: Seri Jeong, Nuri Lee, Su-Kyung Lee, Eun-Jung Cho, Jungwon Hyun, Min-Jeong Park, Wonkeun Song, Eun-Ju Jung, Heungjeong Woo, Yu-Bin Seo, Jin-Ju Park, Hyun-Soo Kim

Journal: Diagnostics (Basel)

PubMed ID: 35054251

Doi: 10.3390/diagnostics12010085

Products & Services: Catalog Antibody

Deferasirox combination with eltrombopag shows anti-myelodysplastic syndrome effects by enhancing iron deprivation-related apoptosis

Authors: Lei Huang, Mengyue Tian, Zhaoyun Liu, Chunyan Liu, Rong Fu

Journal: J Investig Med

PubMed ID: 34921125

Doi: 10.1136/jim-2021-002147

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CASP5 and CR1 as potential biomarkers for Kawasaki disease: an Integrated Bioinformatics-Experimental Study

Authors: Yazdan Rahmati, Hasan Mollanoori, Sajad Najafi, Sajjad Esmaeili, Mohammad Reza Alivand

Journal: BMC Pediatr

PubMed ID: 34895171

Doi: 10.1186/s12887-021-03003-5

Products & Services: Molecular Biology Tools

Critical residues for proteolysis activity of maize chlorotic dwarf virus (MCDV) 3C-like protease and comparison of activity of orthologous waikavirus proteases

Authors: Lucy R Stewart, Matthew Willman, DeeMarie Marty, Anna Emmick Cole, Kristen Willie

Journal: Virology

PubMed ID: 34998226

Doi: 10.1016/j.virol.2021.12.008

Products & Services: Gene Synthesis

Molecular characterization of equine thymidine kinase 1 and preliminary evaluation of its suitability as a serum biomarker for equine lymphoma

Authors: Liya Wang, Lucia Unger, Hanan Sharif, Staffan Eriksson, Vinzenz Gerber, Henrik Rönnberg

Journal: BMC Mol Cell Biol

PubMed ID: 34906077

Doi: 10.1186/s12860-021-00399-x

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Molecular characterization of equine thymidine kinase 1 and preliminary evaluation of its suitability as a serum biomarker for equine lymphoma

Authors: Liya Wang, Lucia Unger, Hanan Sharif, Staffan Eriksson, Vinzenz Gerber, Henrik Rönnberg

Journal: BMC Mol Cell Biol

PubMed ID: 34906077

Doi: 10.1186/s12860-021-00399-x

Products & Services: Custom Vector Construction

A periplasmic cupredoxin with a green CuT15 center is involved in bacterial copper tolerance

Authors: Anne Durand, Mélanie Fouesnard, Marie-Line Bourbon, Anne-Soisig Steunou, Elisabeth Lojou, Pierre Dorlet, Soufian Ouchane

Journal: Metallomics

PubMed ID: 34791351

Doi: 10.1093/mtomcs/mfab067

Products & Services: Custom Vector Construction

miR‑30a‑5p induces the adipogenic differentiation of bone marrow mesenchymal stem cells by targeting FAM13A/Wnt/β‑catenin signaling in aplastic anemia

Authors: Enbo Wang, Yunyan Zhang, Rongmei Ding, Xiaohua Wang, Shumin Zhang, Xinghua Li

Journal: Mol Med Rep

PubMed ID: 34821370

Doi: 10.3892/mmr.2021.12543

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Incomplete radiofrequency ablation induced chemoresistance by up-regulating heat shock protein 70 in hepatocellular carcinoma

Authors: Fuan Wang, Chuan Xu, Guiling Li, Penghua Lv, Jianping Gu

Journal: Exp Cell Res

PubMed ID: 34801560

Doi: 10.1016/j.yexcr.2021.112910

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Crystal structure of Aedes aegypti trypsin inhibitor in complex with μ-plasmin reveals role for scaffold stability in Kazal-type serine protease inhibitor

Authors: Varsha Ashok Walvekar, Karthik Ramesh, Chacko Jobichen, Muthu Kannan, J Sivaraman, R Manjunatha Kini, Yu Keung Mok

Journal: Protein Sci

PubMed ID: 34800067

Doi: 10.1002/pro.4245

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Relative Ratios of Human Seasonal Coronavirus Antibodies Predict the Efficiency of Cross-Neutralization of SARS-CoV-2 Spike Binding to ACE2

Authors: Yannick Galipeau, Vinayakumar Siragam, Geneviève Laroche, Erika Marion, Matthew Greig, Michaeline McGuinty, Ronald A Booth, Yves Durocher, Miroslava Cuperlovic-Culf, Steffany A L Bennett, Angela M Crawley, Patrick M Giguère, Curtis Cooper, Marc-André Langlois

Journal: EBioMedicine

PubMed ID: 34861490

Doi: 10.1016/j.ebiom.2021.103700

Products & Services: Codon Optimization

The Marine Neurotoxin Brevetoxin (PbTx-2) Inhibits and Mammalian Thioredoxin Reductases by Targeting Different Residues

Authors: Ricardo Colon, Michelle Wheater, Emily J Joyce, Emma J Ste Marie, Robert J Hondal, Kathleen S Rein

Journal: J Nat Prod

PubMed ID: 34752085

Doi: 10.1021/acs.jnatprod.1c00795

Products & Services: Codon Optimization

Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs

Authors: Sophie M-C Gobeil, Benjamin G Bobay, Praveen R Juvvadi, D Christopher Cole, Joseph Heitman, William J Steinbach, Ronald A Venters, Leonard D Spicer

Journal: MBio

PubMed ID: 34809463

Doi: 10.1128/mBio.03000-21

Products & Services: Codon Optimization

Multilayered regulation of autophagy by the Atg1 kinase orchestrates spatial and temporal control of autophagosome formation

Authors: Anne Schreiber, Ben C Collins, Colin Davis, Radoslav I Enchev, Angie Sedra, Rocco D'Antuono, Ruedi Aebersold, Matthias Peter

Journal: Mol Cell

PubMed ID: 34798055

Doi: 10.1016/j.molcel.2021.10.024

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Hydrophobicity-tuned anion responsiveness underlies endosomolytic cargo delivery mediated by amphipathic vehicle peptides

Authors: Xiaolong Chen, Hanjie Liu, Ang Li, Shuangshuang Ji, Hao Fei

Journal: J Biol Chem

PubMed ID: 34736897

Doi: 10.1016/j.jbc.2021.101364

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Heterotypic Amyloid β interactions facilitate amyloid assembly and modify amyloid structure

Authors: Katerina Konstantoulea, Patricia Guerreiro, Meine Ramakers, Nikolaos Louros, Liam D Aubrey, Bert Houben, Emiel Michiels, Matthias De Vleeschouwer, Yulia Lampi, Luís F Ribeiro, Joris de Wit, Wei-Feng Xue, Joost Schymkowitz, Frederic Rousseau

Journal: EMBO J

PubMed ID: 34842295

Doi: 10.15252/embj.2021108591

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TG2-gluten complexes as antigens for gluten-specific and transglutaminase-2 specific B cells in celiac disease

Authors: Christian B Lindstad, Alisa E Dewan, Jorunn Stamnaes, Ludvig M Sollid, M Fleur du Pré

Journal: PLoS ONE

PubMed ID: 34731200

Doi: 10.1371/journal.pone.0259082

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T-cell and antibody responses to first BNT162b2 vaccine dose in previously infected and SARS-CoV-2-naive UK health-care workers: a multicentre prospective cohort study

Authors: Adrienn Angyal, Stephanie Longet, Shona C Moore, Rebecca P Payne, Adam Harding, Tom Tipton, Patpong Rongkard, Mohammad Ali, Luisa M Hering, Naomi Meardon, James Austin, Rebecca Brown, Donal Skelly, Natalie Gillson, Sue L Dobson, Andrew Cross, Gurjinder Sandhar, Jonathan A Kilby, Jessica K Tyerman, Alexander R Nicols, Jarmila S Spegarova, Hema Mehta, Hailey Hornsby, Rachel Whitham, Christopher P Conlon, Katie Jeffery, Philip Goulder, John Frater, Christina Dold, Matthew Pace, Ane Ogbe, Helen Brown, M Azim Ansari, Emily Adland, Anthony Brown, Meera Chand, Adrian Shields, Philippa C Matthews, Susan Hopkins, Victoria Hall, William James, Sarah L Rowland-Jones, Paul Klenerman, Susanna Dunachie, Alex Richter, Christopher J A Duncan, Eleanor Barnes, Miles Carroll, Lance Turtle, Thushan I de Silva

Journal: Lancet Microbe

PubMed ID: 34778853

Doi: 10.1016/S2666-5247(21)00275-5

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Identification of immunogenic MHC class II human HER3 peptides that mediate anti-HER3 CD4+ Th1 responses and potential use as a cancer vaccine

Authors: Amrita Basu, Gabriella K Albert, Sabrina Awshah, Jashodeep Datta, Krithika N Kodumudi, Corey Gallen, Amber Beyer, Keiran S M Smalley, Paulo C Rodriguez, Derek R Dukett, Peter A Forsyth, Aixa Soyano, Gary K Koski, Ricardo Lima Barros Costa, Heather Han, Hatem Soliman, Marie Catherine Lee, Pawel Kalinski, Brian J Czerniecki

Journal: Cancer Immunol Res

PubMed ID: 34785506

Doi: 10.1158/2326-6066.CIR-21-0454

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Peptide-coating 2D and small chemical molecules prolong the passage of porcine spermatogonia stem cells

Authors: Ying Zhang, Camila Bruna de Lima, Zhe Zhou, Qiaoyan Shen, Zhenshuo Zhu, Jinlian Hua

Journal: Reprod Domest Anim

PubMed ID: 34748668

Doi: 10.1111/rda.14042

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Suppression of a Novel Vitellogenesis-Inhibiting Hormone Significantly Increases Ovarian Vitellogenesis in the Black Tiger Shrimp,

Authors: Phaivit Laphyai, Thanapong Kruangkum, Charoonroj Chotwiwatthanakun, Wanita Semchuchot, Prawporn Thaijongrak, Prasert Sobhon, Pei-San Tsai, Rapeepun Vanichviriyakit

Journal: Front Endocrinol (Lausanne)

PubMed ID: 34867802

Doi: 10.3389/fendo.2021.760538

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Neoantigen Dendritic Cell Vaccination Combined with Anti-CD38 and CpG Elicits Anti-Tumor Immunity against the Immune Checkpoint Therapy-Resistant Murine Lung Cancer Cell Line LLC1

Authors: Changbo Sun, Koji Nagaoka, Yukari Kobayashi, Hidewaki Nakagawa, Kazuhiro Kakimi, Jun Nakajima

Journal: Cancers (Basel)

PubMed ID: 34771674

Doi: 10.3390/cancers13215508

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Engineering of for 24-Methylene-Cholesterol Production

Authors: Jiao Yang, Changfu Li, Yansheng Zhang

Journal: Biomolecules

PubMed ID: 34827708

Doi: 10.3390/biom11111710

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High-Throughput On-Chip Human Mesenchymal Stromal Cell Potency Prediction

Authors: Rebecca S Schneider, Alexandra C Vela, Evelyn Kendall Williams, Karen E Martin, Wilbur A Lam, Andrés J García

Journal: Adv Healthc Mater

PubMed ID: 34725948

Doi: 10.1002/adhm.202101995

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The flagellin of Vibrio parahaemolyticus induces the inflammatory response of Tetraodon nigroviridis through TLR5M

Authors: Xue Yu, Songze Gao, Jiachang Xu, Yulin Zhao, Yuyou Lu, Niuniu Deng, Haoran Lin, Yong Zhang, Danqi Lu

Journal: Fish Shellfish Immunol

PubMed ID: 34737057

Doi: 10.1016/j.fsi.2021.10.024

Products & Services: Proteins, Expression, Isolation and Analysis

HO Functions as a Downstream Signal of IAA to Mediate HS-Induced Chilling Tolerance in Cucumber

Authors: Xiaowei Zhang, Yanyan Zhang, Chenxiao Xu, Kun Liu, Huangai Bi, Xizhen Ai

Journal: Int J Mol Sci

PubMed ID: 34884713

Doi: 10.3390/ijms222312910

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sp nov, isolated from Arctic tundra soil, and emended descriptions of , and

Authors: Yongping Zhang, Xiaoya Peng, Kun Qin, Jia Liu, Qiang Xu, Jingjing Niu, Yanyan Zheng, Fang Peng

Journal: Int J Syst Evol Microbiol

PubMed ID: 34846279

Doi: 10.1099/ijsem.0.005103

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Pharmacokinetic Assessment of Rottlerin from Using a Highly Sensitive Liquid Chromatography-Tandem Mass Spectrometry-Based Bioanalytical Method

Authors: Diksha Manhas, Abhishek Gour, Nivedita Bhardwaj, Deepak K Sharma, Kuhu Sharma, Bhavna Vij, Shreyans K Jain, Gurdarshan Singh, Utpal Nandi

Journal: ACS Omega

PubMed ID: 34901612

Doi: 10.1021/acsomega.1c04266

Products & Services: Gene Synthesis

Geminin is essential for DNA re-replication in the silk gland cells of silkworms

Authors: Tai-Hang Liu, Xiao-Long Dong, Peng Chen, Qian Zhang, Xiao-Lin Zhou, Cheng Lu, Min-Hui Pan

Journal: Exp Cell Res

PubMed ID: 34843715

Doi: 10.1016/j.yexcr.2021.112951

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Toxicological Evaluation of a Probiotic-Based Delivery System for P8 Protein as an Anti-Colorectal Cancer Drug

Authors: Byung Chull An, Yeo-Sang Yoon, Ho Jin Park, Sangkyun Park, Tai Yeub Kim, Jun Young Ahn, Daebeom Kwon, Oksik Choi, Jin Young Heo, Yongku Ryu, Joong-Hyun Kim, Heejong Eom, Myung Jun Chung

Journal: Drug Des Devel Ther

PubMed ID: 34866901

Doi: 10.2147/DDDT.S319930

Products & Services: Gene Synthesis

Preparation of multiplexed control materials for cancer mutation analysis by genome editing in GM12878 cells

Authors: Guigao Lin, Kuo Zhang, Yanxi Han, Rongxue Peng, Jinming Li

Journal: J Clin Lab Anal

PubMed ID: 34811797

Doi: 10.1002/jcla.24139

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Cul4A-DDB1-mediated monoubiquitination of phosphoglycerate dehydrogenase promotes colorectal cancer metastasis via increased S-adenosylmethionine

Authors: Yajuan Zhang, Hua Yu, Jie Zhang, Hong Gao, Siyao Wang, Shuxian Li, Ping Wei, Ji Liang, Guanzhen Yu, Xiongjun Wang, Xinxiang Li, Dawei Li, Weiwei Yang

Journal: J Clin Invest

PubMed ID: 34720086

Doi: 10.1172/JCI146187

Products & Services: Proteins, Expression, Isolation and Analysis

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