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Evaluating the clinical utility of semi-quantitative luciferase immunosorbent assay using antigens in syphilis diagnosis and treatment monitoring

Authors: Wujian Ke, Cailing Ao, Ran Wei, Xiaozhen Zhu, Jingwei Shui, Jianhui Zhao, Xiaohui Zhang, Liuyuan Wang, Liping Huang, Xinying Leng, Rui Zhu, Jiaxin Wu, Lixia Huang, Nanxuan Huang, Haiying Wang, Wenjia Weng, Ligang Yang, Shixing Tang

Journal: Emerg Microbes Infect

PubMed ID: 38661428

Doi: 10.1080/22221751.2024.2348525

Products & Services: Proteins, Expression, Isolation and Analysis

Design and Evaluation of a Humanized Anti-EGFR huscFv Antibody Fragment in Combination With Metformin in A549 Cells

Authors: Jorge Solis-Estrada, Eder Arredondo-Espinoza, Elizeth Pioquinto-Ávila, Aldo O González-Cruz, Xristo Zarate, Isaías Balderas-Rentería

Journal: Anticancer Res

PubMed ID: 38677771

Doi: 10.21873/anticanres.16998

Products & Services: Proteins, Expression, Isolation and Analysis

Aire mediates tolerance to insulin through thymic trimming of high-affinity T cell clones

Authors: Jennifer A Smith, Benjamin T K Yuen, Whitney Purtha, Jared M Balolong, Jonah D Phipps, Frances Crawford, Jeffrey A Bluestone, John W Kappler, Mark S Anderson

Journal: Proc Natl Acad Sci U S A

PubMed ID: 38709934

Doi: 10.1073/pnas.2320268121

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Optimizing interleukin-6 and 8 expression, clarification and purification in plant cell packs and plants for application in advanced therapy medicinal products and cellular agriculture

Authors: P Opdensteinen, J F Buyel

Journal: J Biotechnol

PubMed ID: 38740307

Doi: 10.1016/j.jbiotec.2024.05.003

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HAP40 modulates mutant Huntingtin aggregation and toxicity in Huntington's disease mice

Authors: Laiqiang Chen, Yiyang Qin, Tingting Guo, Wenzhen Zhu, Jingpan Lin, Tingting Xing, Xuezhi Duan, Yiran Zhang, Eshu Ruan, Xiang Li, Peng Yin, Shihua Li, Xiao-Jiang Li, Su Yang

Journal: Cell Death Dis

PubMed ID: 38744826

Doi: 10.1038/s41419-024-06716-4

Products & Services: Proteins, Expression, Isolation and Analysis

Evolved histone tail regulates 53BP1 recruitment at damaged chromatin

Authors: Jessica L Kelliher, Melissa L Folkerts, Kaiyuan V Shen, Wan Song, Kyle Tengler, Clara M Stiefel, Seong-Ok Lee, Eloise Dray, Weixing Zhao, Brian Koss, Nicholas R Pannunzio, Justin W Leung

Journal: Nat Commun

PubMed ID: 38821984

Doi: 10.1038/s41467-024-49071-w

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A 3D spheroid model of quadruple cell co-culture with improved liver functions for hepatotoxicity prediction

Authors: Baiyang Sun, Zihe Liang, Yupeng Wang, Yue Yu, Xiaobing Zhou, Xingchao Geng, Bo Li

Journal: Toxicology

PubMed ID: 38740170

Doi: 10.1016/j.tox.2024.153829

Products & Services: Proteins, Expression, Isolation and Analysis

Development of a Fully Protective Pandemic Avian Influenza Subunit Vaccine in Insect Pupae

Authors: Ana Falcón, Susana Martínez-Pulgarín, Sergi López-Serrano, Edel Reytor, Miguel Cid, Maria Del Carmen Nuñez, Lorena Córdoba, Ayub Darji, José M Escribano

Journal: Viruses

PubMed ID: 38932122

Doi: 10.3390/v16060829

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Aβ42 and ROS dual-targeted multifunctional nanocomposite for combination therapy of Alzheimer’s disease

Authors: Liding Zhang , Kai Cao , Jun Xie , Xiaohan Liang , Hui Gong , Qingming Luo , Haiming Luo

Journal: J Nanobiotechnology

PubMed ID: 38783363

Doi: doi.org/10.1186/s12951-024-02543-z

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Structural mechanisms of Tad pilus assembly and its interaction with an RNA virus

Authors: Yuhang Wang, Matthew Theodore, Zhongliang Xing, Utkarsh Narsaria, Zihao Yu, Lanying Zeng, Junjie Zhang

Journal: SCIENCE ADVANCES

PubMed ID: 38701202

Doi: 10.1126/sciadv.adl4450

Products & Services: PCR Cloning and Subcloning

TRIM37 is a primate-specific E3 ligase for Huntingtin and accounts for the striatal degeneration in Huntington’s disease

Authors: Yiyang Qin, Laiqiang Chen, Wenzhen Zhu, Jiahong Song, Jingpan Lin, Yuwei Li, Jiawei Zhang, Xichen Song, Tingting Xing, Tingting Guo, Xuezhi Duan, Yiran Zhang, Eshu Ruan, Qi Wang, Bang Li, Weili Yang , Peng Yin, Xiao-Xin Yan, Shihua Li, Xiao-Jiang Li, Su Yang

Journal: SCIENCE ADVANCES

PubMed ID: 38758800

Doi: 10.1126/sciadv.adl2036

Products & Services: Proteins, Expression, Isolation and Analysis

In vivo neutralization of coral snake venoms with an oligoclonal nanobody mixture in a murine challenge model

Authors: Melisa Benard-Valle, Yessica Wouters, Anne Ljungars, Giang Thi Tuyet Nguyen, Shirin Ahmadi, Tasja Wainani Ebersole, Camilla Holst Dahl, Alid Guadarrama-Martínez, Frederikke Jeppesen, Helena Eriksen, Gibran Rodríguez-Barrera, Kim Boddum, Timothy Patrick Jenkins, Sara Petersen Bjørn, Sanne Schoffelen, Bjørn Gunnar Voldborg, Alejandro Alagón & Andreas Hougaard Laustsen

Journal: Nat Commun

PubMed ID: 38773068

Doi: 10.1038/s41467-024-48539-z

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Impact of N-Glycosylation on Protein Structure and Dynamics Linked to Enzymatic C–H Activation in the M. oryzae Lipoxygenase

Authors: Chris Whittington, Ajay Sharma, S Gage Hill, Anthony T Iavarone, Brian M Hoffman, Adam R Offenbacher

Journal: Biochemistry

PubMed ID: 38690768

Doi: 10.1021/acs.biochem.4c00109

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Manganese-dependent transcription regulation by MntR and PerR in Thermus thermophilus HB8

Authors: John K Barrows, Kamya A Stubbs, Irina F Padilla-Montoya, Thomas C Leeper, Michael W Van Dyke

Journal: Mol Microbiol

PubMed ID: 38735869

Products & Services: Nucleic Acid Purification & Analysis

Delineating organizational principles of the endogenous L-A virus by cryo-EM and computational analysis of native cell extracts

Authors: Lisa Schmidt, Christian Tüting, Fotis L Kyrilis, Farzad Hamdi, Dmitry A Semchonok, Gerd Hause, Annette Meister, Christian Ihling, Milton T Stubbs, Andrea Sinz, Panagiotis L Kastritis

Journal: Commun Biol

PubMed ID: 38730276

Doi: 10.1038/s42003-024-06204-7

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Combinatorial Metabolic Engineering for Improving Betulinic Acid Biosynthesis in

Authors: Mei Tang, Xianhao Xu, Yanfeng Liu, Jianghua Li, Guocheng Du, Xueqin Lv, Long Liu

Journal: ACS Synth Biol

PubMed ID: 38748665

Doi: 10.1021/acssynbio.4c00104

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and gene-edited human induced pluripotent stem cells for dissecting the functional roles of -GlcNAcylation in hematopoiesis

Authors: Sudjit Luanpitpong, Kantpitchar Tangkiettrakul, Xing Kang, Pimonwan Srisook, Jirarat Poohadsuan, Parinya Samart, Phatchanat Klaihmon, Montira Janan, Chanchao Lorthongpanich, Chuti Laowtammathron, Surapol Issaragrisil

Journal: Front Cell Dev Biol

PubMed ID: 38752196

Doi: 10.3389/fcell.2024.1361943

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Integrating cryo-OrbiSIMS with computational modelling and metadynamics simulations enhances RNA structure prediction at atomic resolution

Authors: Shannon Ward, Alex Childs, Ceri Staley, Christopher Waugh, Julie A Watts, Anna M Kotowska, Rahul Bhosale, Aditi N Borkar

Journal: Nat Commun

PubMed ID: 38777820

Doi: 10.1038/s41467-024-48694-3

Products & Services: Molecular Biology Reagents

Fluorescence Sensing of Eclampsia Biomarkers via the Immunosorbent Atom Transfer Radical Polymerization Assay

Authors: Nan Ma, Jian Zhang, Jinming Kong, Xueji Zhang

Journal: Anal Chem

PubMed ID: 38728011

Doi: 10.1021/acs.analchem.4c00110

Products & Services: Proteins, Expression, Isolation and Analysis

Ebselen analogues delay disease onset and its course in fALS by on-target SOD-1 engagement

Authors: Seiji Watanabe, Kangsa Amporndanai, Raheela Awais, Caroline Latham, Muhammad Awais, Paul M O'Neill, Koji Yamanaka, S Samar Hasnain

Journal: Sci Rep

PubMed ID: 38802492

Doi: 10.1038/s41598-024-62903-5

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Molecular characteristics of Echinococcus multilocularis FABP1 and its regulatory functions on murine macrophages

Authors: Xiang Li, Peng Liao, Wenjing Zhou, Xinqi Yang, Bin Ye

Journal: Acta Trop

PubMed ID: 38729330

Doi: 10.1016/j.actatropica.2024.107247

Products & Services: Proteins, Expression, Isolation and Analysis

Development and application of a cycleave dual-probe fluorescence quantitative PCR method for simultaneous detection of Mycoplasma gallisepticum ts-11 vaccine strain and non-ts-11 strains

Authors: Xue Wang, Nana Sun, Meng Wang, Hui Wang, Yuhan Liu, Hao Shi, Hao Zhu, Peidong Li, Fuyou Zhang, Tianyao Yang, Zhaoyang Li, Chunguo Liu

Journal: Poult Sci

PubMed ID: 38878745

Doi: 10.1016/j.psj.2024.103907

Products & Services: PCR Cloning and Subcloning

Identification of a novel neurovirulence factor encoded by the cryptic orphan gene UL316 of herpes simplex virus 1

Authors: Akihisa Kato, Ryoji Iwasaki, Kousuke Takeshima, Yuhei Maruzuru, Naoto Koyanagi, Tohru Natsume, Hideo Kusano, Shungo Adachi, Shuichi Kawano, Yasushi Kawaguchi

Journal: J Virol

PubMed ID: 38819171

Doi: 10.1128/jvi.00747-24

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Structural insights into the molecular mechanism of phytoplasma immunodominant membrane protein

Authors: Chang Yi Liu, Han Pin Cheng, Chan Pin Lin, Yi Ting Liao, Tzu Ping Ko, Shin Jen Lin, Shih Shun Lin, Hao Ching Wang

Journal: IUCrJ

PubMed ID: 38656311

Doi: 10.1107/S2052252524003075

Products & Services: Molecular Biology Reagents

Mutation of SIVA, a candidate metastasis gene identified from clonally related bilateral breast cancers, promotes breast cancer cell spread in vitro and in vivo

Authors: Anke Vermehren-Schmaedick, Myron Peto, Wendy Wagoner, Kami E Chiotti, Elizabeth Ramsey, Xiaoyan Wang, Shauna Rakshe, Jessica Minnier, Rosalie Sears, Paul Spellman, Shiuh-Wen Luoh

Journal: PLoS ONE

PubMed ID: 38722955

Doi: 10.1371/journal.pone.0302856

Products & Services: PCR Cloning and Subcloning

Imprinted lncRNA KCNQ1OT1 regulates CDKN1C expression through promoter binding and chromatin folding in pigs

Authors: Yongfeng Zhou, Hao Yu, Daoyu Zhang, Zhengzhu Wang, Qi Li, Xinglan An, Sheng Zhang, Ziyi Li

Journal: Gene

PubMed ID: 38772516

Doi: 10.1016/j.gene.2024.148590

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of phosphorylated small ORF-encoded peptides in Hep3B cells by LC/MS/MS

Authors: Mingbo Peng, Yutian Zhou, Cuihong Wan

Journal: J Proteomics

PubMed ID: 38823442

Doi: 10.1016/j.jprot.2024.105214

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A new strategy to generate nanobodies for the coumaphos based on the synthesized nanobody libraries

Authors: Ruyu Fang, Yingxue Li, Fei Liu, Yifan Liang, Yu Wang, Guohua Zhong, Zhenlin Xu, Bruce D Hammock, Hong Wang

Journal: Food Chem

PubMed ID: 38833869

Doi: 10.1016/j.foodchem.2024.139684

Production of VP3-only virus-like particles of Adeno-associated virus 2 in E coli cells

Authors: Chengyu Fu, Shruthi Gobbooru, Ashley T Martino, Woon-Kai Low

Journal: Protein Expr Purif

PubMed ID: 38754753

Doi: 10.1016/j.pep.2024.106502

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Identification and characterisation of novel CAR-T cells to target IL13Rα2 positive human glioma in vitro and in vivo

Authors: Pamela Leland, Heba Degheidy, Ashley Lea, Steven R Bauer, Raj K Puri, Bharat H Joshi

Journal: Clin Transl Med

PubMed ID: 38685487

Doi: 10.1002/ctm2.1664

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mRNA-LNP prime boost evolves precursors toward VRC01-like broadly neutralizing antibodies in preclinical humanized mouse models

Authors: Xuesong Wang, Christopher A Cottrell, Xiaozhen Hu, Rashmi Ray, Maria Bottermann, Paula Maldonado Villavicencio, Yu Yan, Zhenfei Xie, John E Warner, Jordan Renae Ellis-Pugh, Oleksandr Kalyuzhniy, Alessia Liguori, Jordan R Willis, Sergey Menis, Sebastian Rämisch, Saman Eskandarzade, Michael Kubitz, Ryan Tingle Nicole Phelps, Bettina Groschel, Sunny Himansu, Andrea Carfi, Kathrin H Kirsch, Stephanie R Weldon, Usha Nair, William R Schief, Facundo D Batista

Journal: Science immunology

PubMed ID: 38753808

Doi: 10.1126/sciimmunol.adn0622

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Quercetin induces itaconic acid-mediated M1/M2 alveolar macrophages polarization in respiratory syncytial virus infection

Authors: Li An , Qianwen Zhai , Keyu Tao , Yingcai Xiong , Weiying Ou , Ziwei Yu , Xingyu Yang , Jianjian Ji , Mengjiang Lu

Journal: Phytomedicine

PubMed ID: 38797031

Doi: 10.1016/j.phymed.2024.155761

Products & Services: Proteins, Expression, Isolation and Analysis

Imaging the dynamics of messenger RNA with a bright and stable green fluorescent RNA

Authors: Fangting Zuo, Li Jiang, Ni Su, Yaqiang Zhang, Bingkun Bao, Limei Wang, Yajie Shi, Huimin Yang, Xinyi Huang, Ruilong Li, Qingmei Zeng, Zhengda Chen, Qiuning Lin, Yingping Zhuang, Yuzheng Zhao, Xianjun Chen, Linyong Zhu & Yi Yang

Journal: nature chemical biology

PubMed ID: 38783134

Doi: 10.1038/s41589-024-01629-x

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F Nucleatum enhances oral squamous cell carcinoma proliferation via E-cadherin/β-Catenin pathway

Authors: Zhengrui Li, Yuan Liu, Xufeng Huang, Qi Wang, Rao Fu, Xutao Wen, Ji'an Liu, Ling Zhang

Journal: BMC Oral Health

PubMed ID: 38698370

Doi: 10.1186/s12903-024-04252-3

Products & Services: Proteins, Expression, Isolation and Analysis

Immunogenicity Analysis and Identification of Potential T-Cell Epitopes in C129R Protein of African Swine Fever Virus

Authors: Wenzhu Zhai, Ying Huang, Yuheng He, Yuanyuan Chu, Chunhao Tao, Zhongbao Pang, Zhen Wang, Hongfei Zhu, Hong Jia

Journal: Microorganisms

PubMed ID: 38930438

Doi: 10.3390/microorganisms12061056

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Structural basis of nearest-neighbor cooperativity in the ring-shaped gene regulatory protein TRAP from protein engineering and cryo-EM

Authors: Weicheng Li, Haoyun Yang, Kye Stachowski, Andrew S Norris, Katie Lichtenthal, Skyler Kelly, Paul Gollnick, Vicki H Wysocki, Mark P Foster

Journal: biorxiv

PubMed ID: 38746386

Doi: 10.1101/2024.05.02.592192

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Detection of SARS-CoV-2-Specific Secretory IgA and Neutralizing Antibodies in the Nasal Secretions of Exposed Seronegative Individuals

Authors: Jason S Chwa, Minjun Kim, Yesun Lee, Wesley A Cheng, Yunho Shin, Jaycee Jumarang, Jeffrey M Bender, Pia S Pannaraj

Journal: Viruses

PubMed ID: 38932145

Doi: 10.3390/v16060852

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TALEN-mediated homologous-recombination-based fibroin light chain in-fusion expression system in

Authors: Shihua Yu, Huoqing Zheng, Xiaogang Ye, Xiangping Dai, Xinqiu Wang, Shuo Zhao, Xiaoyan Dai, Boxiong Zhong

Journal: Front Bioeng Biotechnol

PubMed ID: 38832132

Doi: 10.3389/fbioe.2024.1399629

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LINE-1 retrotransposons contribute to mouse PV interneuron development

Authors: Gabriela O Bodea, Juan M Botto, Maria E Ferreiro, Francisco J Sanchez-Luque, Jose de Los Rios Barreda, Jay Rasmussen, Muhammed A Rahman, Laura R Fenlon, Natasha Jansz, Carolina Gubert, Patricia Gerdes, Liviu-Gabriel Bodea, Prabha Ajjikuttira, Darwin J Da Costa Guevara, Linda Cumner, Charles C Bell, Peter Kozulin, Victor Billon, Santiago Morell, Marie-Jeanne H C Kempen, Chloe J Love, Karabi Saha, Lucy M Palmer, Adam D Ewing, Dhanisha J Jhaveri, Sandra R Richardson, Anthony J Hannan, Geoffrey J Faulkner

Journal: Nat Neurosci

PubMed ID: 38773348

Doi: 10.1038/s41593-024-01650-2

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Identification of Fibrinogen as a Plasma Protein Binding Partner for Lecanemab Biosimilar IgG: Implications for Alzheimer's Disease Therapy

Authors: Jean-Pierre Bellier, Andrea Roman, Caitlyn Christiano, Juliana Au Anzai, Stephanie Moreno, Emily C Campbell, Lucas Godwin, Amy Li, Alan Chen, Sarah M Alan, Adriana Saba, Han Bin Yoo, Hyun-Sik Yang, Jasmeer P Chhatwal, Dennis J Selkoe, Lei Liu

Journal: biorxiv

PubMed ID: 38746192

Doi: 10.1101/2024.05.01.591892

Products & Services: Proteins, Expression, Isolation and Analysis

Iguratimod suppresses plasma cell differentiation and ameliorates experimental Sjögren's syndrome in mice by promoting TEC kinase degradation

Authors: Ya-Qi Yang, Yi-Jun Liu, Wen-Xuan Qiao, Wei Jin, Shun-Wei Zhu, Yu-Xi Yan, Qiong Luo, Qiang Xu

Journal: Acta Pharmacol Sin

PubMed ID: 38744938

Doi: 10.1038/s41401-024-01288-7

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A ferritin nanoparticle vaccine based on the hemagglutinin extracellular domain of swine influenza A (H1N1) virus elicits protective immune responses in mice and pigs

Authors: Pan Tang, Enhui Cui, Jinghua Cheng, Benqiang Li, Jie Tao, Ying Shi, Jiajie Jiao, Enqi Du, Jingyu Wang, Huili Liu

Journal: Front Immunol

PubMed ID: 38835763

Doi: 10.3389/fimmu.2024.1361323

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Library Screening, In Vivo Confirmation, and Structural and Bioinformatic Analysis of Pentapeptide Sequences as Substrates for Protein Farnesyltransferase

Authors: Garrett L Schey, Emily R Hildebrandt, You Wang, Safwan Diwan, Holly A Passetti, Gavin W Potts, Andrea M Sprague-Getsy, Ethan R Leoni, Taylor S Kuebler, Yuk Y Sham, James L Hougland, Lorena S Beese, Walter K Schmidt, Mark D Distefano

Journal: Int J Mol Sci

PubMed ID: 38791363

Doi: 10.3390/ijms25105324

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Exploring Syndecan-4 and MLP and Their Interaction in Primary Cardiomyocytes and H9c2 Cells

Authors: Thea Parsberg Støle, Marianne Lunde, Katja Gehmlich, Geir Christensen, William E Louch, Cathrine Rein Carlson

Journal: Cells

PubMed ID: 38891079

Doi: 10.3390/cells13110947

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The E3 ubiquitin-protein ligase UHRF1 promotes adipogenesis and limits fibrosis by suppressing GPNMB-mediated TGF-β signaling

Authors: Muneera Vakayil, Aisha Y Madani, Maha V Agha, Yasser Majeed, Shahina Hayat, Shameem Yonuskunju, Yasmin Ali Mohamoud, Joel Malek, Karsten Suhre, Nayef A Mazloum

Journal: Sci Rep

PubMed ID: 38789534

Doi: 10.1038/s41598-024-62508-y

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Development of a nucleoside-modified mRNA vaccine against clade 2344b H5 highly pathogenic avian influenza virus

Authors: Colleen Furey, Gabrielle Scher, Naiqing Ye, Lisa Kercher, Jennifer DeBeauchamp, Jeri Carol Crumpton, Trushar Jeevan, Christopher Patton, John Franks, Adam Rubrum, Mohamad-Gabriel Alameh, Steven H Y Fan, Anthony T Phan, Christopher A Hunter, Richard J Webby, Drew Weissman, Scott E Hensley

Journal: Nat Commun

PubMed ID: 38782954

Doi: 10.1038/s41467-024-48555-z

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Automated characterization and analysis of expression compatibility between regulatory sequences and metabolic genes in

Authors: Xiao Wen, Jiawei Lin, Chunhe Yang, Ying Li, Haijiao Cheng, Ye Liu, Yue Zhang, Hongwu Ma, Yufeng Mao, Xiaoping Liao, Meng Wang

Journal: Synth Syst Biotechnol

PubMed ID: 38817827

Doi: 10.1016/j.synbio.2024.05.010

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Substrate Affinity Is Not Crucial for Therapeutic L-Asparaginases: Antileukemic Activity of Novel Bacterial Enzymes

Authors: Anna Ściuk, Kinga Wątor, Izabela Staroń, Paulina Worsztynowicz, Kinga Pokrywka, Joanna Sliwiak, Marta Kilichowska, Kamila Pietruszewska, Zofia Mazurek, Anna Skalniak, Krzysztof Lewandowski, Mariusz Jaskolski, Joanna I Loch, Marcin Surmiak

Journal: Molecules

PubMed ID: 38792133

Doi: 10.3390/molecules29102272

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Biophysical insights into the dimer formation of human Sirtuin 2

Authors: Noa Suzuki, Tsuyoshi Konuma, Takahisa Ikegami, Satoko Akashi

Journal: Protein Sci

PubMed ID: 38647411

Doi: 10.1002/pro.4994

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Construction and in vitro characterisation of virus-vectored immunocontraceptive candidates derived from felid alphaherpesvirus 1

Authors: Ellen Cottingham, Thurid Johnstone, Paola K Vaz, Carol A Hartley, Joanne M Devlin

Journal: Vaccine

PubMed ID: 38824082

Doi: 10.1016/j.vaccine.2024.05.047

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