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Conjugation of the 9-kDa Isoform of Granulysin with Liposomes Potentiates Its Cytotoxicity

Authors: Ruth Soler-Agesta, Patricia Guerrero-Ochoa, Joaquín Marco-Brualla, Raquel Ibáñez-Pérez, Isabel Marzo, Luis Martínez-Lostao, Alberto Anel

Journal: Int J Mol Sci

PubMed ID: 35955839

Doi: 10.3390/ijms23158705

Products & Services: Protein and Antibody Isolation

3D bioprinting of in situ vascularized tissue engineered bone for repairing large segmental bone defects

Authors: Mingkui Shen, Lulu Wang, Yi Gao, Li Feng, Chuangye Xu, Sijing Li, Xiaohu Wang, Yulan Wu, Yao Guo, Guoxian Pei

Journal: Mater Today Bio

PubMed ID: 36033373

Doi: 10.1016/j.mtbio.2022.100382

Products & Services: Protein and Antibody Isolation

Enhancement of BCAT2-Mediated Valine Catabolism Stimulates β-Casein Synthesis via the AMPK-mTOR Signaling Axis in Bovine Mammary Epithelial Cells

Authors: Xinling Wang, Jie Xu, Hanfang Zeng, Zhaoyu Han

Journal: J Agric Food Chem

PubMed ID: 35916279

Doi: 10.1021/acs.jafc.2c03629

Products & Services: Protein and Antibody Isolation

IL-22 and Lactobacillus delbrueckii mitigate alcohol-induced exacerbation of DSS-induced colitis

Authors: Abigail R Cannon, Esther H Shim, Paulius V Kuprys, Mashkoor A Choudhry

Journal: J Leukoc Biol

PubMed ID: 35916052

Doi: 10.1002/JLB.4A0122-068R

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GAPDH mediates plant reovirus-induced incomplete autophagy for persistent viral infection in leafhopper vector

Authors: Qian Chen, Yuele Zhang, Hengsong Yang, Xin Wang, Jiping Ren, Dongsheng Jia, Hongyan Chen, Taiyun Wei

Journal: Autophagy

PubMed ID: 36036160

Doi: 10.1080/15548627.2022.2115830

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Conformational buffering underlies functional selection in intrinsically disordered protein regions

Authors: Nicolás S González-Foutel, Juliana Glavina, Wade M Borcherds, Matías Safranchik, Susana Barrera-Vilarmau, Amin Sagar, Alejandro Estaña, Amelie Barozet, Nicolás A Garrone, Gregorio Fernandez-Ballester, Clara Blanes-Mira, Ignacio E Sánchez, Gonzalo de Prat-Gay, Juan Cortés, Pau Bernadó, Rohit V Pappu, Alex S Holehouse, Gary W Daughdrill, Lucía B Chemes

Journal: Nat Struct Mol Biol

PubMed ID: 35948766

Doi: 10.1038/s41594-022-00811-w

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Identification of linear epitopes and their major role in the immunoglobulin E-binding capacity of tropomyosin from

Authors: Nai-Ru Ji, Xin-Yu Han, Chen-Chen Yu, Xin-Rong He, Shi-Tao Rao, Fei Huan, Hong Liu, Gui-Xia Chen, Min-Jie Cao, Guang-Ming Liu

Journal: Food Funct

PubMed ID: 35943407

Doi: 10.1039/d2fo01713j

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PpZAT10 negatively regulates peach cold resistance predominantly mediated by inhibiting VIN activity

Authors: YiChen ,JiachangSun ,YingyingWei ,KefengCao ,ShuJiang ,XingfengShao

Journal: Postharvest Biology and Technology

Doi: 10.1016/j.postharvbio.2022.111952

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Non-viral，specifically targeted CAR-T cells achieve high safety and efficacy in B-NHL

Authors: Jiqin Zhang , Yongxian Hu , Jiaxuan Yang , Wei Li , Mingming Zhang , Qingcan Wang , Linjie Zhang , Guoqing Wei , Yue Tian , Kui Zhao , Ang Chen , Binghe Tan , Jiazhen Cui , Deqi Li , Yi Li , Yalei Qi , Dongrui Wang , Yuxuan Wu , Dali Li , Bing Du , Mingyao Liu , He Huang

Journal: Nature

PubMed ID: 36045296

Doi: 10.1038/s41586-022-05140-y

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Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES.

Authors: Zuben P Brown , Irina S Abaeva , Swastik De , Christopher U T Hellen , Tatyana V Pestova , Joachim Frank

Journal: EMBO J

PubMed ID: 35822879

Doi: 10.15252/embj.2022110581

Products & Services: Gene Synthesis

DPY30 acts as an ASH2L-specific stabilizer to stimulate the enzyme activity of MLL family methyltransferases on different substrates

Authors: Lijie Zhao , Naizhe Huang , Jun Mencius , Yanjing Li , Ying Xu , Yongxin Zheng , Wei He , Na Li , Jun Zheng , Min Zhuang , Shu Quan , Yong Chen

Journal: iScience

PubMed ID: 36065180

Doi: 10.1016/j.isci.2022.104948

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A novel ZsGreen knock-in melanoma cell line reveals the function of CD11b in tumor phagocytosis

Authors: Lichen Zhang, Xinyu Feng, Yingzhuo Shen, Yingbin Wang, Zhuangzhuang Liu, Yuang Ma, Yanrong Gu, Guo Guo, Liangwei Duan, Liaoxun Lu, Yinming Liang, Toby Lawrence, Rong Huang

Journal: Immunol Cell Biol

PubMed ID: 35849045

Doi: 10.1111/imcb.12575

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Crucial role of Ca /CN signalling pathway in the antifungal activity of disenecioyl-cis-khellactone against Botrytis cinerea

Authors: Ping-Ping Song, Yu Wang, Yi-Ping Hou, Xue-Wei Mao, Zong-Liang Liu, Min Wei, Jin-Ping Yu, Bi Wang, Yi-Yun Qian, Lu Yan, Shu Xu, Yan-Qin Jiang, Dong-Qin Zhou, Min Yin, Jian Dou

Journal: Pest Manag Sci

PubMed ID: 35866518

Doi: 10.1002/ps.7085

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Antibody affinity and cross-variant neutralization of SARS-CoV-2 Omicron BA1, BA2 and BA3 following third mRNA vaccination

Authors: Lorenza Bellusci, Gabrielle Grubbs, Fatema Tuz Zahra, David Forgacs, Hana Golding, Ted M Ross, Surender Khurana

Journal: Nat Commun

PubMed ID: 35941152

Doi: 10.1038/s41467-022-32298-w

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Third Early "Booster" Dose Strategy in France of bnt162b2 SARS-CoV-2 Vaccine in Allogeneic Hematopoietic Stem Cell Transplant Recipients Enhances Neutralizing Antibody Responses

Authors: Abdelhakim Ahmed-Belkacem, Rabah Redjoul, Rozenn Brillet, Nazim Ahnou, Mathieu Leclerc, Dennis Salomón López-Molina, Alexandre Soulier, Aurélie Gourgeon, Christophe Rodriguez, Sébastien Maury, Jean-Michel Pawlotsky, Slim Fourati

Journal: Viruses

PubMed ID: 36146735

Doi: 10.3390/v14091928

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The effect of substance P and its common in vivo-formed metabolites on MRGPRX2 and human mast cell activation

Authors: Lin Hsin, Nithya A Fernandopulle, Jie Ding, Chris Lumb, Nicholas Veldhuis, John A Karas, Susan E Northfield, Graham A Mackay

Journal: Pharmacol Res Perspect

PubMed ID: 35904495

Doi: 10.1002/prp2.990

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Expanding the antiviral potential of the mosquito lipid-transfer protein AEG12 against SARS-CoV-2 using hydrophobic antiviral ligands

Authors: Alexander C Y Foo, Bernard A P Lafont, Geoffrey A Mueller

Journal: FEBS Lett

PubMed ID: 35891619

Doi: 10.1002/1873-3468.14456

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Validation of a Novel Fluorescent Lateral Flow Assay for Rapid Qualitative and Quantitative Assessment of Total Anti-SARS-CoV-2 S-RBD Binding Antibody Units (BAU) from Plasma or Fingerstick Whole-Blood of COVID-19 Vaccinees

Authors: Nadin Younes, Duaa W Al-Sadeq, Farah M Shurrab, Hadeel T Zedan, Haissam Abou-Saleh, Bushra Y Abo-Halawa, Fatima M AlHamaydeh, Amira E Elsharafi, Hanin I Daas, Swapna Thomas, Sahar Aboalmaaly, Afra Al Farsi, Reeham Al-Buainain, Samar Ataelmannan, Jiji Paul, Amana Salih Al Saadi, Hadi M Yassine, Amin F Majdalawieh, Ahmed Ismail, Laith J Abu-Raddad, Gheyath K Nasrallah

Journal: Vaccines (Basel)

PubMed ID: 36016206

Doi: 10.3390/vaccines10081318

Products & Services: Protein and Antibody Isolation

Significance of lncRNA CDKN2B-AS1 in Interventional Therapy of Liver Cancer and the Mechanism under Its Participation in Tumour Cell Growth via miR-199a-5p

Authors: Lu Xu, Haotian Wu, Jianhua Pan, Zhiheng Chen, Linan Du

Journal: J Oncol

PubMed ID: 36081669

Doi: 10.1155/2022/2313416

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D-Lactic Acid Production from Sugarcane Bagasse by Genetically Engineered

Authors: Warasirin Sornlek, Kittapong Sae-Tang, Akaraphol Watcharawipas, Sriwan Wongwisansri, Sutipa Tanapongpipat, Lily Eurwilaichtr, Verawat Champreda, Weerawat Runguphan, Peter J Schaap, Vitor A P Martins Dos Santos

Journal: J Fungi (Basel)

PubMed ID: 36012804

Doi: 10.3390/jof8080816

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KIF20A promotes the development of fibrosarcoma via PI3K-Akt signaling pathway

Authors: Zheng Jin, Shuang Tao, Chao Zhang, Damo Xu, Zhenhua Zhu

Journal: Exp Cell Res

PubMed ID: 36037925

Doi: 10.1016/j.yexcr.2022.113322

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Pericentrin interacts with Kinesin-1 to drive centriole motility

Authors: Matthew R Hannaford, Rong Liu, Neil Billington, Zachary T Swider, Brian J Galletta, Carey J Fagerstrom, Christian Combs, James R Sellers, Nasser M Rusan

Journal: J Cell Biol

PubMed ID: 35929834

Doi: 10.1083/jcb.202112097

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Sappanone a prevents diabetic kidney disease by inhibiting kidney inflammation and fibrosis the NF-κB signaling pathway

Authors: Zhe Wang, Zhida Chen, Xinyi Wang, Yepeng Hu, Jing Kong, Jiabin Lai, Tiekun Li, Bibi Hu, Yikai Zhang, Xianan Zheng, Xiaoxian Liu, Shengyao Wang, Shu Ye, Qiao Zhou, Chao Zheng

Journal: Front Pharmacol

PubMed ID: 36052141

Doi: 10.3389/fphar.2022.953004

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Repression of linc01555 up-regulates angiomotin-p130 via the microRNA-122-5p/clic1 axis to impact vasculogenic mimicry-mediated chemotherapy resistance in small cell lung cancer

Authors: Dan Li, YanWei Shen, Hui Ren, Li Wang, Jin Yang, Yuan Wang

Journal: Cell Cycle

PubMed ID: 36045598

Doi: 10.1080/15384101.2022.2112132

Products & Services: Gene Synthesis

Transcriptomic and Phenotypic Analysis of CRISPR/Cas9-Mediated Knockout in Zebrafish

Authors: Qianqian Yan, Wenhao Li, Xiaoting Gong, Ruiqin Hu, Liangbiao Chen

Journal: Genes (Basel)

PubMed ID: 36011351

Doi: 10.3390/genes13081441

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Endothelial Cell Infection by Guinea Pig Cytomegalovirus Is a Lytic or Persistent Infection Depending on Tissue Origin but Requires Viral Pentamer Complex and pp65 Tegument Protein

Authors: K Yeon Choi, Nadia El-Hamdi, Alistair McGregor

Journal: J Virol

PubMed ID: 36000848

Doi: 10.1128/jvi.00831-22

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TLNRD1 is a CCM complex component and regulates endothelial barrier integrity

Authors: Neil J. Ball; Sujan Ghimire; Gautier Follain; Ada O. Pajari; Diana Wurzinger; Monika Vaitkevi i t ; Alana R. Cowell; Bence Berki; Johanna Ivaska; Ilkka Paatero; Benjamin T. Goult; Guillaume Jacquemet

Journal: The Journal of cell biology

PubMed ID: 39013281

Doi: 10.1083/jcb.202310030

Multi-Omics Immune Interaction Networks in Lung Cancer Tumorigenesis, Proliferation, and Survival

Authors: Qing Ye; Justin Hickey; Kathleen Summers; Brianne Falatovich; Marieta Gencheva; Timothy D. Eubank; Alexey V. Ivanov; Nancy Lan Guo

Journal: International Journal of Molecular Sciences

PubMed ID: 36499305

Doi: 10.3390/ijms232314978

Structure of a nucleosome-bound MuvB transcription factor complex reveals DNA remodelling

Authors: Marios G Koliopoulos , Reyhan Muhammad , Theodoros I Roumeliotis , Fabienne Beuron , Jyoti S Choudhary , Claudio Alfieri

Journal: Nat Commun

PubMed ID: 36038598

Doi: 10.1038/s41467-022-32798-9

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A specific anti-IFITM2 antibody bars the way to SARS-CoV-2 entry into host cells.

Authors: Anna Basile , Carla Zannella , Margot De Marco , Gianluigi Franci , Massimiliano Galdiero , Giuseppina Sanna , Aldo Manzin , Massimiliano Chetta , Maria Caterina Turco , Alessandra Rosati , Liberato Marzullo

Journal: biorxiv

Doi: doi.org/10.1101/2022.08.04.502768

Products & Services: Monoclonal Antibody Services Recombinant Antibody Expression

Refolding and characterization of a diabody against Pfs25, a vaccine candidate of Plasmodium falciparum

Authors: Deepak K Jagannath, Ashwathi Valiyaparambil, Vysakh K Viswanath, Manjunath A Hurakadli, Neelagandan Kamariah, Alifia C Jafer, Chhaya Patole, Sabyasachi Pradhan, Naveen Kumar, Anirudha Lakshminarasimhan

Journal: Anal Biochem

PubMed ID: 35944694

Doi: 10.1016/j.ab.2022.114830

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SOX transcription factors direct TCF-independent WNT/β-catenin responsive transcription to govern cell fate in human pluripotent stem cells

Authors: Shreyasi Mukherjee, David M Luedeke, Leslie McCoy, Makiko Iwafuchi, Aaron M Zorn

Journal: Cell Rep

PubMed ID: 36001974

Doi: 10.1016/j.celrep.2022.111247

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Defective bone repletion in aged Balb/cBy mice was caused by impaired osteoblastic differentiation

Authors: Matilda H-C Sheng, Kin-Hing William Lau, Charles H Rundle, Anar Alsunna, Sean M Wilson, David J Baylink

Journal: J Bone Miner Metab

PubMed ID: 35947191

Doi: 10.1007/s00774-022-01361-3

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Enhancing arginase 2 expression using target site blockers as a strategy to modulate macrophage phenotype

Authors: Chiara De Santi, Frances K Nally, Remsha Afzal, Conor P Duffy, Stephen Fitzsimons, Stephanie L Annett, Tracy Robson, Jennifer K Dowling, Sally-Ann Cryan, Claire E McCoy

Journal: Mol Ther Nucleic Acids

PubMed ID: 36090747

Doi: 10.1016/j.omtn.2022.08.004

Products & Services: Recombinant Proteins

Generation of hepatoma cell lines deficient in microsomal triglyceride transfer protein

Authors: Narasimha Anaganti, Atrayee Chattopadhyay, John T Poirier, M Mahmood Hussain

Journal: J Lipid Res

PubMed ID: 35931202

Doi: 10.1016/j.jlr.2022.100257

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Immunogenicity of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection and Ad26CoV2S Vaccination in People Living With Human Immunodeficiency Virus (HIV)

Authors: Khadija Khan, Gila Lustig, Mallory Bernstein, Derseree Archary, Sandile Cele, Farina Karim, Muneerah Smith, Yashica Ganga, Zesuliwe Jule, Kajal Reedoy, Yoliswa Miya, Ntombifuthi Mthabela, Nombulelo P Magula, Richard Lessells, Tulio de Oliveira, Bernadett I Gosnell, Salim Abdool Karim, Nigel Garrett, Willem Hanekom, Linda-Gail Bekker, Glenda Gray, Jonathan M Blackburn, Mahomed-Yunus S Moosa, Alex Sigal

Journal: Clin Infect Dis

PubMed ID: 34893824

Doi: 10.1093/cid/ciab1008

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LIMP2 gene, evolutionarily conserved regulation by TFE3, relieves lysosomal stress induced by cholesterol

Authors: Hanze Guo, Yingying Zhu, Jiarui Li, Qipeng Zhang, Yan Chi

Journal: Life Sci

PubMed ID: 35987341

Doi: 10.1016/j.lfs.2022.120888

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Structure-Guided Insight into the Specificity and Mechanism of a Parasitic Nucleoside Hydrolase

Authors: Samantha N Muellers, Mattias M Nyitray, Nicholas Reynarowych, Edina Saljanin, Annie Laurie Benzie, Alan R Schoenfeld, Brian J Stockman, Karen N Allen

Journal: Biochemistry

PubMed ID: 35994320

Doi: 10.1021/acs.biochem.2c00361

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Antibodies from primary humoral responses modulate the recruitment of naive B cells during secondary responses

Authors: Jeroen M J Tas, Ja-Hyun Koo, Ying-Cing Lin, Zhenfei Xie, Jon M Steichen, Abigail M Jackson, Blake M Hauser, Xuesong Wang, Christopher A Cottrell, Jonathan L Torres, John E Warner, Kathrin H Kirsch, Stephanie R Weldon, Bettina Groschel, Bartek Nogal, Gabriel Ozorowski, Sandhya Bangaru, Nicole Phelps, Yumiko Adachi, Saman Eskandarzadeh, Michael Kubitz, Dennis R Burton, Daniel Lingwood, Aaron G Schmidt, Usha Nair, Andrew B Ward, William R Schief, Facundo D Batista

Journal: Immunity

PubMed ID: 35987201

Doi: 10.1016/j.immuni.2022.07.020

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Tumor-infiltrated activated B cells suppress liver metastasis of colorectal cancers

Authors: Yuqiu Xu, Zhuang Wei, Mei Feng, Dexiang Zhu, Shenglin Mei, Zhongen Wu, Qingyang Feng, Wenju Chang, Meiling Ji, Chenglong Liu, Yuanyuan Zhu, Lian Shen, Fan Yang, Yijiao Chen, Yuxiong Feng, Jianmin Xu, Di Zhu

Journal: Cell Rep

PubMed ID: 36044847

Doi: 10.1016/j.celrep.2022.111295

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Knockdown of HSP110 attenuates hypoxia-induced pulmonary hypertension in mice through suppression of YAP/TAZ-TEAD4 pathway

Authors: Haitao Liu, Sha Zhang, Yi Liu, Jing Ma, Wei Chen, Tao Yin, Tongbin Li, Bin Liang, Ling Tao

Journal: Respir Res

PubMed ID: 35986277

Doi: 10.1186/s12931-022-02124-4

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Post-translational control of beige fat biogenesis by PRDM16 stabilization

Authors: Qiang Wang, Huixia Li, Kazuki Tajima, Anthony R P Verkerke, Zachary H Taxin, Zhishuai Hou, Joanne B Cole, Fei Li, Jake Wong, Ichitaro Abe, Rachana N Pradhan, Tadashi Yamamuro, Takeshi Yoneshiro, Joel N Hirschhorn, Shingo Kajimura

Journal: Nature

PubMed ID: 35978186

Doi: 10.1038/s41586-022-05067-4

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Immunological profiles associated with distinct parasitemic states in volunteers undergoing malaria challenge in Gabon

Authors: Mikhael D Manurung, Sanne E de Jong, Yvonne Kruize, Yoanne D Mouwenda, Madeleine Eunice Betouke Ongwe, Yabo Josiane Honkpehedji, Jeannot Frézus Zinsou, Jean Claude Dejon-Agobe, Stephen L Hoffman, Peter G Kremsner, Ayola Akim Adegnika, Rolf Fendel, Benjamin Mordmüller, Meta Roestenberg, Bertrand Lell, Maria Yazdanbakhsh

Journal: Sci Rep

PubMed ID: 35922467

Doi: 10.1038/s41598-022-17725-8

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Targeted inhibition of ubiquitin signaling reverses metabolic reprogramming and suppresses glioblastoma growth

Authors: Rossella Delle Donne, Rosa Iannucci, Laura Rinaldi, Luca Roberto, Maria A Oliva, Emanuela Senatore, Domenica Borzacchiello, Luca Lignitto, Giorgio Giurato, Francesca Rizzo, Assunta Sellitto, Francesco Chiuso, Salvatore Castaldo, Giovanni Scala, Virginia Campani, Valeria Nele, Giuseppe De Rosa, Chiara D'Ambrosio, Corrado Garbi, Andrea Scaloni, Alessandro Weisz, Concetta Ambrosino, Antonella Arcella, Antonio Feliciello

Journal: Commun Biol

PubMed ID: 35918402

Doi: 10.1038/s42003-022-03639-8

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Defining the ultrastructure of the hematopoietic stem cell niche by correlative light and electron microscopy

Authors: Sobhika Agarwala, Keun-Young Kim, Sebastien Phan, Saeyeon Ju, Ye Eun Kong, Guillaume A Castillon, Eric A Bushong, Mark H Ellisman, Owen J Tamplin

Journal: Elife

PubMed ID: 35943143

Doi: 10.7554/eLife.64835

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Genetically Engineered Pigs as Efficient Salivary Gland Bioreactors for Production of Therapeutically Valuable Human Nerve Growth Factor

Authors: Fang Zeng, Sha Liao, Zhe Kuang, Qingchun Zhu, Hengxi Wei, Junsong Shi, Enqin Zheng, Zheng Xu, Sixiu Huang, Linjun Hong, Ting Gu, Jie Yang, Huaqiang Yang, Gengyuan Cai, Stefan Moisyadi, Johann Urschitz, Zicong Li, Zhenfang Wu

Journal: Cells

PubMed ID: 35954224

Doi: 10.3390/cells11152378

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Structural Study of SARS-CoV-2 Antibodies Identifies a Broad-Spectrum Antibody That Neutralizes the Omicron Variant by Disassembling the Spike Trimer

Authors: Wuqiang Zhan, Xiaolong Tian, Xiang Zhang, Shenghui Xing, Wenping Song, Qianying Liu, Aihua Hao, Yuxia Hu, Meng Zhang, Tianlei Ying, Zhenguo Chen, Fei Lan, Lei Sun

Journal: J Virol

PubMed ID: 35924918

Doi: 10.1128/jvi.00480-22

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Screening of six cation exchange resins for high binding capacity, monomer purity and step yield: A case study

Authors: Wenwen Lu, Zhenzhen Zhang, Shengwei Zhang, Ting Zhang, Yan Wan, Yifeng Li

Journal: Protein Expr Purif

PubMed ID: 35970491

Doi: 10.1016/j.pep.2022.106155

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IL11 Stimulates IL33 Expression and Proinflammatory Fibroblast Activation across Tissues

Authors: Anissa A Widjaja, Sonia Chothani, Sivakumar Viswanathan, Joyce Wei Ting Goh, Wei-Wen Lim, Stuart A Cook