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α-toxin activates the NLRP3 inflammasome by engaging GPI-anchored proteins

Authors: Weidong Jing, Jordan Lo Pilato, Callum Kay, Shouya Feng, Daniel Enosi Tuipulotu, Anukriti Mathur, Cheng Shen, Chinh Ngo, Anyang Zhao, Lisa A Miosge, Sidra A Ali, Elizabeth E Gardiner, Milena M Awad, Dena Lyras, Avril A B Robertson, Nadeem O Kaakoush, Si Ming Man

Journal: Sci Immunol

PubMed ID: 35594341

Doi: 10.1126/sciimmunol.abm1803

Products & Services: Gene Synthesis

Computational approach for binding prediction of SARS-CoV-2 with neutralizing antibodies

Authors: Daria Beshnova, Yan Fang, Mingjian Du, Yehui Sun, Fenghe Du, Jianfeng Ye, Zhijian James Chen, Bo Li

Journal: Comput Struct Biotechnol J

PubMed ID: 35530743

Doi: 10.1016/j.csbj.2022.04.038

Products & Services: Gene Synthesis

An Immunoinformatic Strategy to Develop New Multi-epitope Vaccine

Authors:

Journal: INT J PEPT RES THER

PubMed ID: 35573911

Doi: 10.1007/s10989-022-10406-0

Products & Services: Bacterial Expression

Transiently Transfected Mammalian Cell Cultures: An Adaptable and Effective Platform for Virus-like Particle-Based Vaccines against Foot-and-Mouth Disease Virus

Authors: Michael Puckette, Victoria Primavera, Erica Martel, Jose Barrera, William Hurtle, Benjamin Clark, Barbara Kamicker, Mariceny Zurita, David Brake, John Neilan

Journal: Viruses

PubMed ID: 35632734

Doi: 10.3390/v14050989

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Comparison of Four Systems for SARS-CoV-2 Antibody at Three Time Points after SARS-CoV-2 Vaccination

Authors: Jong Do Seo, Minjeong Nam, Tae Hwan Lee, Yeon-Sun Ahn, Seon-Hyeon Shin, Hye Young Han, Hee-Won Moon

Journal: Diagnostics (Basel)

PubMed ID: 35741159

Doi: 10.3390/diagnostics12061349

Products & Services: Catalog Antibodies

Designing a novel E2-IFN-γ fusion protein against CSFV by immunoinformatics and structural vaccinology approaches

Authors: Yanmin Zhang, Weijian Zhang, Jun Cheng, Xuping Liu, Shiwei Miao, Wen-Song Tan, Liang Zhao

Journal: Appl Microbiol Biotechnol

PubMed ID: 35524776

Doi: 10.1007/s00253-022-11919-w

Products & Services: Molecular Biology Tools

AbSE Workflow: Rapid Identification of the Coding Sequence and Linear Epitope of the Monoclonal Antibody at the Single-cell Level

Authors: Lerong Ma, HongSheng Ouyang, Ang Su, Yuanzhu Zhang, Daxin Pang, Tao Zhang, Ruize Sun, Wentao Wang, Zicong Xie, Dongmei Lv

Journal: ACS Synth Biol

PubMed ID: 35503752

Doi: 10.1021/acssynbio.2c00018

Products & Services: DNA Sequencing

Type B and type A influenza polymerases have evolved distinct binding interfaces to recruit the RNA polymerase II CTD

Authors: Tim Krischuns, Catherine Isel, Petra Drncova, Maria Lukarska, Alexander Pflug, Sylvain Paisant, Vincent Navratil, Stephen Cusack, Nadia Naffakh

Journal: PLoS Pathog

PubMed ID: 35605026

Doi: 10.1371/journal.ppat.1010328

Products & Services: PCR Cloning and Subcloning

Structural and functional analysis of an inter-Spike bivalent neutralizing antibody against SARS-CoV-2 variants

Authors: Yaning Li, Qing Fan, Bing Zhou, Yaping Shen, Yuanyuan Zhang, Lin Cheng, Furong Qi, Shuo Song, Yingying Guo, Renhong Yan, Bin Ju, Zheng Zhang

Journal: iScience

PubMed ID: 35607524

Doi: 10.1016/j.isci.2022.104431

Products & Services: Protein and Antibody Isolation

Epicardium-derived cells organize through tight junctions to replenish cardiac muscle in salamanders

Authors: Elif Eroglu, Christopher Y T Yen, Yat-Long Tsoi, Nevin Witman, Ahmed Elewa, Alberto Joven Araus, Heng Wang, Tamara Szattler, Chimezie H Umeano, Jesper Sohlmér, Alexander Goedel, András Simon, Kenneth R Chien

Journal: Nat Cell Biol

PubMed ID: 35550612

Doi: 10.1038/s41556-022-00902-2

Products & Services: Plasmid DNA Preparation

A Novel Small RNA, DsrO, in Deinococcus radiodurans Promotes Methionine Sulfoxide Reductase () Expression for Oxidative Stress Adaptation

Authors: Yun Chen, Mingming Zhao, Mengli Lv, Min Lin, Jin Wang, Kaijing Zuo

Journal: Appl Environ Microbiol

PubMed ID: 35575549

Doi: 10.1128/aem.00038-22

Products & Services: Polyclonal Antibody Services

Selenium in Proteins: Conformational Changes Induced by Se Substitution on Methionine, as Studied in Isolated Model Peptides by Optical Spectroscopy and Quantum Chemistry

Authors: Gildas Goldsztejn, Venkateswara Rao Mundlapati, Valérie Brenner, Eric Gloaguen, Michel Mons

Journal: Molecules

PubMed ID: 35630640

Doi: 10.3390/molecules27103163

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Potent and pan-neutralization of SARS-CoV-2 variants of concern by DARPins

Authors: Vikas Chonira, Young Do Kwon, Jason Gorman, James Brett Case, Zhiqiang Ku, Rudo Simeon, Ryan G Casner, Darcy R Harris, Adam S Olia, Tyler Stephens, Lawrence Shapiro, Hannah Boyd, Yaroslav Tsybovsky, Florian Krammer, Michael S Diamond, Peter D Kwong, Zhiqiang An, Zhilei Chen

Journal: biorxiv

PubMed ID: 35677079

Doi: 10.1101/2022.05.30.493765

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New insights into the mechanism of iron transport through the bacterial Ftr system present in pathogens

Authors: Anne Soisig Steunou, Armelle Vigouroux, Magali Aumont-Nicaise, Stéphane Plancqueel, Alain Boussac, Soufian Ouchane, Solange Moréra

Journal: FEBS J

PubMed ID: 35527501

Doi: 10.1111/febs.16476

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Developing G value as an indicator for assessing the molecular status of immobilized antibody

Authors: Dongdong Gao, Fang Cheng, Xinglong Wang, Heqing Yang, Chong Liu, Chunmei Li, Eva Murong Yang, Gang Cheng, Wei He

Journal: Colloids Surf B Biointerfaces

PubMed ID: 35665639

Doi: 10.1016/j.colsurfb.2022.112593

Products & Services: Mammalian Expression

α-Synuclein Impacts on Intrinsic Neuronal Network Activity Through Reduced Levels of Cyclic AMP and Diminished Numbers of Active Presynaptic Terminals

Authors: Kristian Leite, Pretty Garg, F Paul Spitzner, Sofia Guerin Darvas, Mathias Bähr, Viola Priesemann, Sebastian Kügler

Journal: Front Mol Neurosci

PubMed ID: 35721317

Doi: 10.3389/fnmol.2022.868790

Products & Services: Endotoxin Detection & Removal System

An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses

Authors: Lihong Liu, Sho Iketani, Yicheng Guo, Eswar R Reddem, Ryan G Casner, Manoj S Nair, Jian Yu, Jasper F-W Chan, Maple Wang, Gabriele Cerutti, Zhiteng Li, Nicholas C Morano, Candace D Castagna, Laura Corredor, Hin Chu, Shuofeng Yuan, Vincent Kwok-Man Poon, Chris Chun-Sing Chan, Zhiwei Chen, Yang Luo, Marcus Cunningham, Alejandro Chavez, Michael T Yin, David S Perlin, Moriya Tsuji, Kwok-Yung Yuen, Peter D Kwong, Zizhang Sheng, Yaoxing Huang, Lawrence Shapiro, David D Ho

Journal: Sci Transl Med

PubMed ID: 35438546

Doi: 10.1126/scitranslmed.abn6859

Products & Services: Plasmid DNA Preparation

Rapid, sensitive, and low-cost detection of Escherichia coli bacteria in contaminated water samples using a phage-based assay

Authors: Luis F Alonzo, Paras Jain, Troy Hinkley, Nick Clute-Reinig, Spencer Garing, Ethan Spencer, Van T T Dinh, David Bell, Sam Nugen, Kevin P Nichols, Anne-Laure M Le Ny

Journal: Sci Rep

PubMed ID: 35562180

Doi: 10.1038/s41598-022-11468-2

Products & Services: Plasmid DNA Preparation

Type B CTD Proteins Secreted by the Type IX Secretion System Associate with PorP-like Proteins for Cell Surface Anchorage

Authors: Dhana G Gorasia, Christine A Seers, Jacqueline E Heath, Michelle D Glew, Hamid Soleimaninejad, Catherine A Butler, Mark J McBride, Paul D Veith, Eric C Reynolds

Journal: Int J Mol Sci

PubMed ID: 35628493

Doi: 10.3390/ijms23105681

Products & Services: Polyclonal Antibody Services

Key dimer interface residues impact the catalytic activity of 3CLpro, the main protease of SARS-CoV-2

Authors: Juliana C Ferreira, Samar Fadl, Wael M Rabeh

Journal: J Biol Chem

PubMed ID: 35568197

Doi: 10.1016/j.jbc.2022.102023

Products & Services: Mutant Libraries

Comparative Immunogenicity of Bacterially Expressed Soluble Trimers and Nanoparticle Displayed Influenza Hemagglutinin Stem Immunogens

Authors: Uddipan Kar, Sara Khaleeq, Priyanka Garg, Madhuraj Bhat, Poorvi Reddy, Venkada Subramanian Vignesh, Aditya Upadhyaya, Mili Das, Ghadiyaram Chakshusmathi, Suman Pandey, Somnath Dutta, Raghavan Varadarajan

Journal: Front Immunol

PubMed ID: 35720346

Doi: 10.3389/fimmu.2022.890622

Products & Services: Codon Optimization

Construction of ajmalicine and sanguinarine de novo biosynthetic pathways using stable integration sites in yeast

Authors: Tengfei Liu , Yuanwei Gou , Bei Zhang , Rui Gao , Chang Dong , Mingming Qi , Lihong Jiang , Xuanwei Ding , Chun Li , Jiazhang Lian

Journal: Biotechnol Bioeng

PubMed ID: 35060115

Doi: doi.org/10.1002/bit.28040

Products & Services: Gene Synthesis

Using large-scale multi-module NRPS to heterologously prepare highly efficient lipopeptide biosurfactants in recombinant Escherichia coli

Authors: Ting Zhang , Qiang Zhou

Journal: Enzyme Microb Technol

PubMed ID: 35660853

Doi: doi.org/10.1016/j.enzmictec.2022.110068

Products & Services: Gene Synthesis

Gold Glyconanoparticles Combined with 91-99 Peptide of the Bacterial Toxin, Listeriolysin O, Are Efficient Immunotherapies in Experimental Bladder Tumors

Authors: Hector Terán-Navarro, Andrea Zeoli, David Salines-Cuevas, Marco Marradi, Noemi Montoya, Elena Gonzalez-Lopez, Javier Gonzalo Ocejo-Vinyals, Mario Dominguez-Esteban, Jose Luis Gutierrez-Baños, Felix Campos-Juanatey, Sonsoles Yañez-Diaz, Almudena Garcia-Castaño, Fernando Rivera, Ignacio Duran, Carmen Alvarez-Dominguez

Journal: Cancers (Basel)

PubMed ID: 35626016

Doi: 10.3390/cancers14102413

Products & Services: Protein and Antibody Isolation

AntiV-SGN: a universal antiviral strategy to combat both RNA and DNA viruses by destroying their nucleic acids without sequence limitation

Authors: Kun Tian, Zhen Qi, Ying Chi, Huanran Qiang, Pei Wang, Yu Liu, Guohua Zhou, Fengcai Zhu, Qinglong Guo, Shu Xu

Journal: Microb Biotechnol

PubMed ID: 35611874

Doi: 10.1111/1751-7915.14076

Products & Services: Gene Fragments

Cell-Penetrating Peptide TAT-HuR-HNS3 Suppresses Proinflammatory Gene Expression via Competitively Blocking Interaction of HuR with Its Partners

Authors: Ke Wang, Haibin Tong, Yitian Gao, Lan Xia, Xin Jin, Xiaoxue Li, Xianlu Zeng, Istvan Boldogh, Yueshuang Ke, Xueqing Ba

Journal: J Immunol

PubMed ID: 35444028

Doi: 10.4049/jimmunol.2200002

Products & Services: Endotoxin Detection & Removal System

3,5,3'-Triiodothyronine-Loaded Liposomes Inhibit Hepatocarcinogenesis Inflammation-Associated Macrophages

Authors: Gangqi Sun, Xiaojuan Hou, Luyao Zhang, Hengyan Zhang, Changchun Shao, Fengwei Li, Chen Zong, Rong Li, Junxia Shi, Xue Yang, Li Zhang

Journal: Front Oncol

PubMed ID: 35646705

Doi: 10.3389/fonc.2022.877982

Products & Services: Protein Electrophoresis and Western

Identification and Functional Characterization of Peptides With Antimicrobial Activity From the Syphilis Spirochete,

Authors: Simon Houston, Ethan Schovanek, Kate M E Conway, Sarah Mustafa, Alloysius Gomez, Raghavendran Ramaswamy, Ayman Haimour, Martin J Boulanger, Lisa A Reynolds, Caroline E Cameron

Journal: Front Microbiol

PubMed ID: 35722306

Doi: 10.3389/fmicb.2022.888525

Products & Services: Peptide Synthesis

Carboxymethylcellulose biofunctionalized ternary quantum dots for subcellular-targeted brain cancer nanotheranostics

Authors: Alexandra A P Mansur, Mayara R B Paiva, Oliver A L Cotta, Luciana M Silva, Isadora C Carvalho, Nádia S V Capanema, Sandhra M Carvalho, Érica A Costa, Nelson R Martin, Roselene Ecco, Beatriz S Santos, Silvia L Fialho, Zélia I P Lobato, Herman S Mansur

Journal: Int J Biol Macromol

PubMed ID: 35513094

Doi: 10.1016/j.ijbiomac.2022.04.207

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Phosphatidylinositol transfer protein/planar cell polarity axis regulates neocortical morphogenesis by supporting interkinetic nuclear migration

Authors: Zhigang Xie, Vytas A Bankaitis

Journal: Cell Rep

PubMed ID: 35649377

Doi: 10.1016/j.celrep.2022.110869

Products & Services: Polyclonal Antibody Services

The Toxoplasma glucan phosphatase TgLaforin utilizes a distinct functional mechanism that can be exploited by therapeutic inhibitors

Authors: Robert D Murphy, Tiantian Chen, Jianping Lin, Rongjun He, Li Wu, Caden R Pearson, Savita Sharma, Carl D Vander Kooi, Anthony P Sinai, Zhong-Yin Zhang, Craig W Vander Kooi, Matthew S Gentry

Journal: J Biol Chem

PubMed ID: 35640720

Doi: 10.1016/j.jbc.2022.102089

Products & Services: Mutant Libraries

Crosstalk of hepatocyte nuclear factor 4a and glucocorticoid receptor in the regulation of lipid metabolism in mice fed a high-fat-high-sugar diet

Authors: Hong Lu, Xiaohong Lei, Rebecca Winkler, Savio John, Devendra Kumar, Wenkuan Li, Yazen Alnouti

Journal: Lipids Health Dis

PubMed ID: 35614477

Doi: 10.1186/s12944-022-01654-6

Products & Services: Mutagenesis Services

Antibody engineering improves neutralization activity against K417 spike mutant SARS-CoV-2 variants

Authors: Lili Li, Meiling Gao, Peng Jiao, Shulong Zu, Yong-Qiang Deng, Dingyi Wan, Yang Cao, Jing Duan, Saba R Aliyari, Jie Li, Yueyue Shi, Zihe Rao, Cheng-Feng Qin, Yu Guo, Genhong Cheng, Heng Yang

Journal: Cell Biosci

PubMed ID: 35581593

Doi: 10.1186/s13578-022-00794-7

Products & Services: Catalog Antibodies

Identification, expression and subcellular localization of Orc1 in the microsporidian Nosema bombycis

Authors: Fuzhen Sun, Guanyu Zhu, Ping He, Erjun Wei, Runpeng Wang, Qiang Wang, Xudong Tang, Yiling Zhang, Zhongyuan Shen

Journal: Gene

PubMed ID: 35609797

Doi: 10.1016/j.gene.2022.146607

Products & Services: Protein and Antibody Isolation

Preclinical Studies of Granulysin-Based Anti-MUC1-Tn Immunotoxins as a New Antitumoral Treatment

Authors: Patricia Guerrero-Ochoa, Raquel Ibáñez-Pérez, Germán Berbegal-Pinilla, Diederich Aguilar, Isabel Marzo, Francisco Corzana, Martha Minjárez-Sáenz, Javier Macías-León, Blanca Conde, Javier Raso, Ramón Hurtado-Guerrero, Alberto Anel

Journal: Biomedicines

PubMed ID: 35740244

Doi: 10.3390/biomedicines10061223

Products & Services: Plasmid DNA Preparation

Electrostatics Drive the Molecular Chaperone BiP to Preferentially Bind Oligomerized States of a Client Protein

Authors: Erin E Deans, Judy L M Kotler, Wei-Shao Wei, Timothy O Street

Journal: J Mol Biol

PubMed ID: 35597552

Doi: 10.1016/j.jmb.2022.167638

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A minimal bile salt excretory pump promoter allows bile acid-driven physiological regulation of transgene expression from a gene therapy vector

Authors: Javier Martínez-García, Manuela Molina, Leticia Odriozola, Angie Molina, Gloria González-Aseguinolaza, Nicholas D Weber, Cristian Smerdou

Journal: Cell Biosci

PubMed ID: 35641984

Doi: 10.1186/s13578-022-00803-9

Products & Services: PCR Cloning and Subcloning

Sox2 levels regulate the chromatin occupancy of WNT mediators in epiblast progenitors responsible for vertebrate body formation

Authors: Robert Blassberg, Harshil Patel, Thomas Watson, Mina Gouti, Vicki Metzis, M Joaquina Delás, James Briscoe

Journal: Nat Cell Biol

PubMed ID: 35550614

Doi: 10.1038/s41556-022-00910-2

Products & Services: Custom DNA/RNA Oligos

Discovery and functional assessment of a novel adipocyte population driven by intracellular Wnt/β-catenin signaling in mammals

Authors: Zhi Liu, Tian Chen, Sicheng Zhang, Tianfang Yang, Yun Gong, Hong-Wen Deng, Ding Bai, Weidong Tian, YiPing Chen

Journal: Elife

PubMed ID: 35503096

Doi: 10.7554/eLife.77740

Products & Services: Molecular Biology Reagents

The Carotenoid Esterification Gene Controls Pale-Yellow Petal Color in Flowering Chinese Cabbage ( L subsp )

Authors: Peirong Li, Sirui Lv, Deshuang Zhang, Tongbing Su, Xiaoyun Xin, Weihong Wang, Xiuyun Zhao, Yangjun Yu, Yaowei Zhang, Shuancang Yu, Fenglan Zhang

Journal: Front Plant Sci

PubMed ID: 35592555

Doi: 10.3389/fpls.2022.844140

Products & Services: Gene Fragments

Novel small molecules targeting bZIP23 TF improve stomatal conductance and photosynthesis under mild drought stress by regulating ABA

Authors: Vanitha Pa, Preethi Vijayaraghavareddy, Akshay Uttarkar, Akashata Dawane, Sujitha D, Ashwin V, Babitha Kc, Vidya Niranjan, Sheshshayee Ms, Anuradha Cv, Udayakumar Makarla, Ramu S Vemanna

Journal: FEBS J

PubMed ID: 35445538

Doi: 10.1111/febs.16461

Products & Services: PCR Cloning and Subcloning

Luteolin suppresses TNF-α-induced inflammatory injury and senescence of nucleus pulposus cells via the Sirt6/NF-κB pathway

Authors: Tian Xie, Jun Yuan, Ling Mei, Ping Li, Ruijie Pan

Journal: Exp Ther Med

PubMed ID: 35747154

Doi: 10.3892/etm.2022.11396

Products & Services: Custom DNA/RNA Oligos

Performance analysis among multiple fully automated anti-SARS-CoV-2 antibody measurement reagents: A potential indicator for the correlation of protection in the antibody titer

Authors: Ryo Kobayashi, Ema Suzuki, Ryosei Murai, Makito Tanaka, Yoshihiro Fujiya, Satoshi Takahashi

Journal: J Infect Chemother

PubMed ID: 35667939

Doi: 10.1016/j.jiac.2022.05.016

Products & Services: Recombinant Proteins

Phosphorylation of HORMA-domain protein HTP-3 at Serine 285 is dispensable for crossover formation

Authors: Debabrata Das, Shalini Trivedi, Jitka Blazícková, Swathi Arur, Nicola Silva

Journal: G3 (Bethesda)

PubMed ID: 35389463

Doi: 10.1093/g3journal/jkac079

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Immunogenicity, safety, and antiphospholipid antibodies after SARS-CoV-2 vaccine in patients with primary antiphospholipid syndrome

Authors: Flavio Signorelli, Gustavo Guimarães Moreira Balbi, Nadia E Aikawa, Clovis A Silva, Léonard de Vinci Kanda Kupa, Ana C Medeiros-Ribeiro, Emily Fn Yuki, Sandra G Pasoto, Carla Gs Saad, Eduardo F Borba, Luciana Parente Costa Seguro, Tatiana Pedrosa, Vitor Antonio de Angeli Oliveira, Ana Luisa Cerqueira de Sant'Ana Costa, Carolina T Ribeiro, Roseli Eliana Beseggio Santos, Danieli Castro Oliveira Andrade, Eloisa Bonfá

Journal: Lupus

PubMed ID: 35593174

Doi: 10.1177/09612033221102073

Products & Services: Catalog Antibodies

Optimization of the antimicrobial peptide Bac7 by deep mutational scanning

Authors: Philipp Koch, Steven Schmitt, Alexander Heynisch, Anja Gumpinger, Irene Wüthrich, Marina Gysin, Dimitri Shcherbakov, Sven N Hobbie, Sven Panke, Martin Held

Journal: BMC Biol

PubMed ID: 35578204

Doi: 10.1186/s12915-022-01304-4

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CBR3-AS1 Accelerates the Malignant Proliferation of Gestational Choriocarcinoma Cells by Stabilizing SETD4

Authors: Yajuan Zhang, Hongxiu Zhang, Xiaolei Zhang, Bin Liu

Journal: Dis Markers

PubMed ID: 35655916

Doi: 10.1155/2022/7155525

Products & Services: Plasmid DNA Preparation

The CD8α hinge is intrinsically disordered with a dynamic exchange that includes proline cis-trans isomerization

Authors: Xiang Chen, Justin M Mirazee, Katarzyna A Skorupka, Hiroshi Matsuo, Philippe Youkharibache, Naomi Taylor, Kylie J Walters

Journal: J Magn Reson

PubMed ID: 35617919

Doi: 10.1016/j.jmr.2022.107234

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SOLVx therapeutics vaccine - Activate T-cell immunity using broad surveillance epitope strategy against mutant strains SARS-COV2

Authors: Md Shamsuddin Sultan Khan, John A Catanzaro

Journal: Biomed Pharmacother

PubMed ID: 35653885

Doi: 10.1016/j.biopha.2022.113212

Products & Services: Peptide Synthesis

Mitochondrial and glucose metabolic dysfunctions in granulosa cells induce impaired oocytes of polycystic ovary syndrome through Sirtuin 3

Authors: Qing Zhang, Jun Ren, Fangfang Wang, Manman Pan, Long Cui, Mingqian Li, Fan Qu

Journal: Free Radic Biol Med

PubMed ID: 35594990

Doi: 10.1016/j.freeradbiomed.2022.05.010

Products & Services: Protein Electrophoresis and Western